M. Froeyen

发表

Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase.

P. Herdewijn, L. Delang, M. Froeyen, 2012, Antiviral research.

Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase

M. Froeyen, J. Neyts, P. Leyssen, 2020, Molecules.

3-(imidazo[1,2-a:5,4-b']dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase.

M. Froeyen, J. Neyts, J. Chezal, 2016, Antiviral research.

Invading Escherichia coli Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA).

P. Marlière, P. Herdewijn, J. Rozenski, 2019, Journal of the American Chemical Society.

N-Alkylated Aminoacyl sulfamoyladenosines as Potential Inhibitors of Aminoacylation Reactions and Microcin C Analogues Containing D-Amino Acids

J. Rozenski, K. Severinov, M. Froeyen, 2013, PloS one.

Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors.

J. Rozenski, A. Venkatesham, M. Froeyen, 2017, European journal of medicinal chemistry.

The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 Replication

R. Hilgenfeld, M. Froeyen, J. Neyts, 2014, Antimicrobial Agents and Chemotherapy.

CYCLOHEXENE NUCLEIC ACIDS (CeNA) FORM STABLE DUPLEXES WITH RNA AND INDUCE RNASE H ACTIVITY

P. Herdewijn, I. Luyten, M. Froeyen, 2001 .

Improved algorithm for the discrete Fourier transform

Louis Hellemans, Mathy Froeyen, M. Froeyen, 1985 .

Reply to ‘‘Comments on ‘Improved algorithm for the discrete Fourier transform’ ’’ [Rev. Sci. Instrum. 58, 714 (1987)]

M. Froeyen, L. Hellemans, 1987 .

New class of early‐stage enterovirus inhibitors with a novel mechanism of action

W. Luyten, L. Delang, M. Froeyen, 2017, Antiviral research.

5'-(N-aminoacyl)-sulfonamido-5'-deoxyadenosine: attempts for a stable alternative for aminoacyl-sulfamoyl adenosines as aaRS inhibitors.

J. Rozenski, M. Froeyen, A. Van Aerschot, 2015, European journal of medicinal chemistry.

Hybridisation Potential of 1',3'-Di-O-methylaltropyranoside Nucleic Acids

J. Rozenski, A. Venkatesham, M. Froeyen, 2015, Molecules.

Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3-b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity

Jie Ying Gao, S. Knapp, J. Dye, 2019 .

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68

R. Hilgenfeld, L. Delang, M. Froeyen, 2015, Antimicrobial Agents and Chemotherapy.

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

X. de Lamballerie, P. Herdewijn, L. Delang, 2014, The Journal of antimicrobial chemotherapy.

Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems.

P. Herdewijn, M. Froeyen, F. De Riccardis, 2018, Chemistry.

Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

D. Zajonc, S. Remesh, M. Froeyen, 2017, Scientific Reports.

Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species

L. Delang, M. Froeyen, J. Neyts, 2020, bioRxiv.

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

Vitor B. Pinheiro, M. U. Mirza, P. Herdewijn, 2019, Nucleic acids research.

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

Vitor B. Pinheiro, M. U. Mirza, P. Herdewijn, 2019, Nucleic acids research.

Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.

P. Herdewijn, M. Froeyen, Szu-Yuan Pu, 2019, Bioorganic & medicinal chemistry.

Discovery of 7-N-piperazinylthiazolo[5,4-d]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity.

P. Herdewijn, J. Rozenski, M. Froeyen, 2011, Journal of medicinal chemistry.

Base substituted 5'-O-(N-isoleucyl)sulfamoyl nucleoside analogues as potential antibacterial agents.

J. Rozenski, M. Froeyen, A. Van Aerschot, 2014, Bioorganic & medicinal chemistry.

Characterization and molecular modeling of the inclusion complexes of 2-(2-nitrovinyl) furan (G-0) with cyclodextrines.

R. Busson, M. Froeyen, G. Van den Mooter, 2012, International journal of pharmaceutics.

Structural properties and mechanical stability of lithium-ion based materials. A theoretical study

M. Nguyen, M. Froeyen, Y. Zulueta, 2017 .

Structural properties and mechanical stability of monoclinic lithium disilicate

M. Froeyen, J. Dawson, Y. Zulueta, 2017 .

Structural basis for the role of LYS220 as proton donor for nucleotidyl transfer in HIV-1 reverse transcriptase.

Samuel L. C. Moors, P. Herdewijn, A. Ceulemans, 2011, Biophysical chemistry.

3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase.

P. Marlière, P. Herdewijn, M. Froeyen, 2011, Organic & biomolecular chemistry.

A novel high‐vacuum and variable‐temperature stopped‐flow device for high‐purity polymerization kinetics

A. Persoons, M. Froeyen, A. Rives, 1991 .

Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors

P. Herdewijn, L. Delang, M. Froeyen, 2011 .

Comparative Study of the Genetic Barriers and Pathways towards Resistance of Selective Inhibitors of Hepatitis C Virus Replication

L. Delang, M. Froeyen, J. Neyts, 2011, Antimicrobial Agents and Chemotherapy.

CYCLOHEXENE NUCLEIC ACIDS (CeNA) FORM STABLE DUPLEXES WITH RNA AND INDUCE RNASE H ACTIVITY

P. Herdewijn, I. Luyten, M. Froeyen, 2001 .

A Derivate of the Antibiotic Doxorubicin Is a Selective Inhibitor of Dengue and Yellow Fever Virus Replication In Vitro

P. Herdewijn, A. Gamarnik, M. Froeyen, 2010, Antimicrobial Agents and Chemotherapy.

Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds

L. Naesens, L. Pinto, M. D. Duque, 2013, Antiviral Research.

Binary genetic cassettes for selecting XNA-templated DNA synthesis in vivo.

P. Marlière, P. Herdewijn, F. Liu, 2013, Angewandte Chemie.

1',5'-Anhydro-L-ribo-hexitol Adenine Nucleic Acids (α-L-HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World.

P. Herdewijn, M. Froeyen, A. Van Aerschot, 2015, The Journal of organic chemistry.

A synthetic substrate of DNA polymerase deviating from the bases, sugar, and leaving group of canonical deoxynucleoside triphosphates.

P. Marlière, P. Herdewijn, J. Rozenski, 2013, Chemistry & biology.

Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

M. Vignuzzi, L. Delang, M. Froeyen, 2017, Journal of Virology.

Molecular Dynamics of Double Stranded Xylo-Nucleic Acid.

P. Herdewijn, A. Ceulemans, Amutha Ramaswamy, 2017, Journal of chemical theory and computation.

Helical structure of xylose-DNA.

P. Herdewijn, A. Ceulemans, Amutha Ramaswamy, 2010, Journal of the American Chemical Society.

1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase

H. Munier-Lehmann, S. van Calenbergh, M. Froeyen, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.

S. Knapp, J. Dye, P. Herdewijn, 2019, Journal of medicinal chemistry.

Hepatitis C virus polymerase-polymerase contact interface: significance for virus replication and antiviral design.

J. Encinar, Neerja Kaushik-Basu, M. Froeyen, 2014, Antiviral research.

A novel benzonitrile analogue inhibits rhinovirus replication.

C. Lacroix, M. Froeyen, J. Neyts, 2014, The Journal of antimicrobial chemotherapy.

Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.

M. Froeyen, J. Neyts, P. Leyssen, 2014, Antiviral research.

Solution structure and conformational dynamics of deoxyxylonucleic acids (dXNA): an orthogonal nucleic acid candidate.

P. Herdewijn, A. Ceulemans, Amutha Ramaswamy, 2012, Chemistry.

Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.

P. Herdewijn, M. Froeyen, D. Schols, 2021, European journal of medicinal chemistry.

Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines.

P. Herdewijn, M. Froeyen, Szu-Yuan Pu, 2019, European journal of medicinal chemistry.

Base substituted 5'-O-(N-isoleucyl)sulfamoyl nucleoside analogues as potential antibacterial agents.

J. Rozenski, M. Froeyen, A. Van Aerschot, 2014, Bioorganic & medicinal chemistry.

NMR study on the interaction of the conserved CREX 'stem-loop' in the Hepatitis E virus genome with a naphthyridine-based ligand.

P. Herdewijn, M. Froeyen, M. Abramov, 2015, Organic & biomolecular chemistry.

Oxygen vacancy generation in rare‐earth‐doped SrTiO3

M. Froeyen, J. Dawson, Y. Zulueta, 2016 .

Molecular Dynamics of Double Stranded Xylo-Nucleic Acid.

P. Herdewijn, A. Ceulemans, Amutha Ramaswamy, 2017, Journal of chemical theory and computation.

Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline

M. Froeyen, E. Lescrinier, R. Montalvão, 2024, Nucleic acids research.

The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 Replication

R. Hilgenfeld, M. Froeyen, J. Neyts, 2014, Antimicrobial Agents and Chemotherapy.

Toward the computer-aided discovery of FabH inhibitors. Do predictive QSAR models ensure high quality virtual screening performance?

Maykel Cruz-Monteagudo, Ann Nowé, Yunierkis Pérez-Castillo, 2014, Molecular Diversity.

Synthesis of a 3,7-Disubstituted Isothiazolo[4,3-b]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase

M. Froeyen, S. de Jonghe, Luc Van Meervelt, 2024, Molecules.

Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids

P. Marlière, P. Herdewijn, M. Froeyen, 2007, Nucleic acids research.