Y. Higashikuni

发表

Diagnosing Heart Failure from Chest X-Ray Images Using Deep Learning.

I. Komuro, T. Matsumoto, S. Kodera, 2020, International heart journal.

Advancing therapeutic applications of synthetic gene circuits.

T. Lu, Y. Higashikuni, W. Chen, 2017, Current opinion in biotechnology.

Relationship between Blood Pressure and Chronic Kidney Disease in the Japanese Population: The Lower the Better Even in Individuals without Hypertension?

R. Nagai, Y. Higashikuni, N. Ishizaka, 2008, Hypertension Research.

Pioglitazone Reduces Vascular Lipid Accumulation in Angiotensin II-Induced Hypertensive Rat.

I. Komuro, K. Koike, R. Nagai, 2015, Journal of atherosclerosis and thrombosis.

The ATP-Binding Cassette Transporter BCRP1/ABCG2 Plays a Pivotal Role in Cardiac Repair After Myocardial Infarction Via Modulation of Microvascular Endothelial Cell Survival and Function

H. Kusuhara, Y. Sugiyama, Kazuto Nakamura, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Impact of the Distance from the Stent Edge to the Residual Plaque on Edge Restenosis following Everolimus-Eluting Stent Implantation

I. Komuro, Y. Higashikuni, A. Kiyosue, 2015, PloS one.

The Effectiveness of a Deep Learning Model to Detect Left Ventricular Systolic Dysfunction from Electrocardiograms.

K. Fujiu, S. Kodera, H. Shinohara, 2021, International heart journal.

Impact of renal insufficiency on clinical and angiographic outcomes following percutaneous coronary intervention with sirolimus‐eluting stents

G. Nakazawa, K. Tanabe, Y. Higashikuni, 2007, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

I. Imoto, H. Sakaue, Y. Higashikuni, 2016, Science Advances.

Efficacy of culprit plaque assessment by 64-slice multidetector computed tomography to predict transient no-reflow phenomenon during percutaneous coronary intervention.

G. Nakazawa, K. Tanabe, Y. Higashikuni, 2008, American heart journal.

Serum osteoprotegerin levels and long‐term prognosis in subjects with stable coronary artery disease

H. Hashimoto, Y. Ikari, Y. Higashikuni, 2010, Journal of thrombosis and haemostasis : JTH.

Inhibition of activated factor X by rivaroxaban attenuates neointima formation after wire‐mediated vascular injury

Y. Higashikuni, M. Sata, M. Shimabukuro, 2018, European journal of pharmacology.

Toll‐Like Receptor‐2 Mediates Adaptive Cardiac Hypertrophy in Response to Pressure Overload Through Interleukin‐1β Upregulation via Nuclear Factor κB Activation

O. Nureki, I. Komuro, R. Nagai, 2013, Journal of the American Heart Association.

Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice.

Y. Higashikuni, K. Kusunose, M. Sata, 2019, International heart journal.

Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice.

Y. Higashikuni, M. Sata, M. Shimabukuro, 2017, Vascular pharmacology.

Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice.

Y. Higashikuni, M. Sata, M. Shimabukuro, 2016, Vascular pharmacology.

Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia

Y. Higashikuni, K. Kusunose, M. Sata, 2018, Front. Cardiovasc. Med..

Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia

Y. Higashikuni, K. Kusunose, M. Sata, 2018, Front. Cardiovasc. Med..

Single-Nucleotide-Resolution Computing and Memory in Living Cells

T. Lu, Y. Higashikuni, Jicong Cao, 2018, bioRxiv.

Candesartan Ameliorates Cardiac Dysfunction Observed in Angiotensin-Converting Enzyme 2-Deficient Mice

H. Nishimatsu, Kazuto Nakamura, K. Kugiyama, 2008, Hypertension Research.

Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II–Induced Atherosclerosis

T. Akasaka, K. Masuda, I. Imoto, 2019, Journal of the American Heart Association.

Give a Leg Up: Screening for Peripheral Artery Disease after Acute Myocardial Infarction

Y. Higashikuni, M. Sata, Wenhao Liu, 2021, Journal of atherosclerosis and thrombosis.

Reversible left ventricular hypertrophy after tako-tsubo-like cardiomyopathy

R. Nagai, Y. Higashikuni, M. Sata, 2005, Acta cardiologica.

Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates.

Karen G. N. Oshiro, T. Lu, Y. Higashikuni, 2018 .

Deep learning-based approach for detecting signs of atrial septal defect 2 on chest radiographs: a proof of concept study

K. Fujiu, S. Kodera, H. Shinohara, 2022 .

Midterm Follow‐up After Retrievable Inferior Vena Cava Filter Placement in Venous Thromboembolism Patients With or Without Malignancy

I. Komuro, Y. Higashikuni, A. Kiyosue, 2015, Clinical cardiology.

Age prediction from coronary angiography using a deep neural network: Age as a potential label to extract prognosis-related imaging features

K. Fujiu, S. Kodera, H. Shinohara, 2022, PloS one.

Biodegradable Extremely-Small-Diameter Vascular Graft Made of Silk Fibroin can be Implanted in Mice

I. Komuro, Y. Higashikuni, T. Asakura, 2020, Journal of atherosclerosis and thrombosis.

Giant left atrial myxoma that caused mitral valve obstruction and pulmonary hypertension.

I. Komuro, M. Ono, Masafumi Watanabe, 2015, International journal of cardiology.

Vascular antispastic medication should take priority over other antihypertensives after coronary artery bypass grafting using a radial artery conduit.

M. Ono, Y. Higashikuni, T. Kitamura, 2011, Interactive cardiovascular and thoracic surgery.

Endoplasmic reticulum stress-activated nuclear factor-kappa B signaling pathway induces the upregulation of cardiomyocyte dopamine D1 receptor in heart failure.

I. Komuro, S. Nomura, Toshihiro Yamaguchi, 2022, Biochemical and biophysical research communications.

Interleukin-6-producing giant cell carcinoma of the lung with multicentric Castleman's disease-like presentation.

Y. Higashikuni, M. Mori, H. Kino, 2007, Internal medicine.

Giant left coronary artery aneurysm in a patient with mixed connective tissue disease.

R. Nagai, Y. Higashikuni, Y. Hirata, 2007, Internal medicine.

Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice.

Y. Higashikuni, T. Wakatsuki, M. Sata, 2015, Atherosclerosis.

Endothelial PGC-1α mediates vascular dysfunction in diabetes.

F. Jaffer, H. Watada, N. Sawada, 2014, Cell metabolism.

Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications

Y. Higashikuni, M. Sata, Wenhao Liu, 2021, International journal of molecular sciences.

The ATP-Binding Cassette Transporter ABCG2 Protects Against Pressure Overload–Induced Cardiac Hypertrophy and Heart Failure by Promoting Angiogenesis and Antioxidant Response

Kazuto Nakamura, R. Nagai, Y. Higashikuni, 2012, Arteriosclerosis, Thrombosis and Vascular Biology.

HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9.

Y. Higashikuni, H. Kurobe, M. Sata, 2013, Atherosclerosis.

Dipeptidyl peptidase-4 inhibitor , linagliptin , ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E de fi cient mice

Y. Higashikuni, M. Sata, M. Shimabukuro, 2016 .

Impact of culprit plaque composition on the no-reflow phenomenon in patients with acute coronary syndrome: an intravascular ultrasound radiofrequency analysis.

G. Nakazawa, K. Tanabe, Y. Higashikuni, 2008, Circulation journal : official journal of the Japanese Circulation Society.

Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice

R. Nagai, Y. Higashikuni, Y. Hirata, 2012, Hypertension Research.

Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates

Karen G. N. Oshiro, T. Lu, Y. Higashikuni, 2018, Communications Biology.

Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice.

Y. Higashikuni, M. Sata, D. Fukuda, 2018, Atherosclerosis.

Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation.

Y. Higashikuni, T. Wakatsuki, Y. Taketani, 2016, Atherosclerosis.

Prevalence of Carotid Artery Stenosis in Patients With Coronary Artery Disease in Japanese Population

G. Nakazawa, K. Tanabe, Y. Ikari, 2005, Stroke.

Sirolimus-eluting stents suppress neointimal formation irrespective of metallic allergy.

G. Nakazawa, K. Tanabe, Y. Higashikuni, 2008, Circulation journal : official journal of the Japanese Circulation Society.

Relationship between coronary artery remodeling and plaque composition in culprit lesions: an intravascular ultrasound radiofrequency analysis.

G. Nakazawa, K. Tanabe, Y. Higashikuni, 2007, Circulation journal : official journal of the Japanese Circulation Society.

Incidence and clinical impact of coronary stent fracture after sirolimus‐eluting stent implantation

G. Nakazawa, K. Tanabe, Y. Higashikuni, 2007, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

Automatic Detection of Left Ventricular Dilatation and Hypertrophy from Electrocardiograms Using Deep Learning.

T. Kokubo, Y. Matsuyama, K. Fujiu, 2022, International heart journal.

NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload

T. Imamura, Y. Higashikuni, E. Takimoto, 2022, Circulation.

Advancing CRISPR-Based Programmable Platforms beyond Genome Editing in Mammalian Cells.

T. Lu, Y. Higashikuni, 2019, ACS synthetic biology.

Deep learning-based age estimation from chest X-rays indicates cardiovascular prognosis

K. Ozaki, Rei Kawakami, K. Fujiu, 2022, Communications medicine.

Deep learning-based chest X-ray age serves as a novel biomarker for cardiovascular aging

K. Ozaki, Rei Kawakami, I. Komuro, 2021, bioRxiv.

An explainable artificial intelligence-enabled electrocardiogram analysis model for the classification of reduced left ventricular function

K. Tanabe, K. Fujiu, S. Kodera, 2023, European heart journal. Digital health.

Deep learning model to detect significant aortic regurgitation using electrocardiography: Detection model for aortic regurgitation.

K. Fujiu, S. Kodera, H. Shinohara, 2021, Journal of cardiology.

Automatic detection of vessel structure by deep learning using intravascular ultrasound images of the coronary arteries.

K. Fujiu, S. Kodera, H. Shinohara, 2021, PloS one.

Clinical and angiographic outcomes of sirolimus-eluting stents implantation in Japanese patients in daily practice.

Y. Higashikuni, Y. Onuma, K. Hara, 2006, Circulation journal : official journal of the Japanese Circulation Society.

Difference of culprit plaque composition between patients with and without pre-infarction angina: an intravascular ultrasound radiofrequency analysis.

G. Nakazawa, K. Tanabe, Y. Higashikuni, 2009, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

Optimizing antihypertensive therapy in patients with diabetes mellitus

Y. Higashikuni, M. Sata, Wenhao Liu, 2022, Hypertension Research.

Deep Learning Algorithm to Detect Cardiac Sarcoidosis From Echocardiographic Movies.

M. Uehara, K. Fujiu, S. Kodera, 2021, Circulation journal : official journal of the Japanese Circulation Society.