J. Iatridis

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Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies

O. M. Torre, Victoria Mroz, M. Bartelstein, 2018, Annals of the New York Academy of Sciences.

Neonatal mouse intervertebral discs heal with restored function following herniation injury

O. M. Torre, A. Huang, J. Iatridis, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Animal models for studying the etiology and treatment of low back pain

A. V. van Wijnen, H. Im, D. Sakai, 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability.

Samuel K. Cho, P. Roughley, R. Linhardt, 2015, The spine journal : official journal of the North American Spine Society.

Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines.

C. Giannarelli, D. Purmessur, J. Iatridis, 2015, Osteoarthritis and cartilage.

Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

Zachary R. Schoepflin, R. Kandel, M. Risbud, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Development and validation of a bioreactor system for dynamic loading and mechanical characterization of whole human intervertebral discs in organ culture.

J. Iatridis, B. Walter, A. Hecht, 2014, Journal of biomechanics.

Combined Anti-Inflammatory and Anti-AGE Drug Treatments Have a Protective Effect on Intervertebral Discs in Mice with Diabetes

G. Striker, J. Iatridis, S. Illien-Junger, 2013, PloS one.

3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer.

K. Costa, J. Iatridis, Joseph Borrello, 2018, Additive manufacturing.

Advanced glycation end products cause RAGE‐dependent annulus fibrosus collagen disruption and loss identified using in situ second harmonic generation imaging in mice intervertebral disk in vivo and in organ culture models

J. Iatridis, S. Illien-Jünger, D. Laudier, 2020, JOR spine.

Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model

A. Lai, B. Winkelstein, G. Pasinetti, 2019, PloS one.

Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model

A. Lai, B. Winkelstein, G. Pasinetti, 2019, PloS one.

Homeostasis disrupted by strain mechanosensing

J. Iatridis, S. Illien-Jünger, T. DiStefano, 2019, Nature Biomedical Engineering.

New horizons in spine research: Disc biology, tissue engineering, biomechanics, translational, and clinical research

M. Risbud, J. Iatridis, C. Dahia, 2018, JOR spine.

Dietary advanced glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs

O. M. Torre, J. Iatridis, S. Illien-Jünger, 2018, Disease Models & Mechanisms.

Dietary Advanced Glycation End-Product Consumption Leads to Mechanical Stiffening of Murine Intervertebral Discs

O. M. Torre, J. Iatridis, S. Illien-Jünger, 2018, bioRxiv.

Molecular mechanisms of biological aging in intervertebral discs

James D. Kang, D. Kletsas, M. Risbud, 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Comparison and optimization of sheep in vivo intervertebral disc injury model

S. Grad, J. Iatridis, A. Hecht, 2022, JOR spine.

Intervertebral Disk Degeneration and Repair.

Samuel K. Cho, A. Vaccaro, J. Iatridis, 2017, Neurosurgery.

Fibrin-Genipin Hydrogel for Cartilage Tissue Engineering in Nasal Reconstruction

J. Iatridis, P. Nasser, J. Rosenberg, 2019, The Annals of otology, rhinology, and laryngology.

Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs.

O. M. Torre, J. Iatridis, A. Hecht, 2017, Tissue engineering. Part A.

Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model.

P. Roughley, D. Purmessur, J. Iatridis, 2014, The spine journal : official journal of the North American Spine Society.

Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development

Samuel K. Cho, B. A. Ballif, D. Purmessur, 2013, Arthritis Research & Therapy.

Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells

Benjamin A Walter, Samuel K. Cho, Alan Weinberg, 2015, Spine.

Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells

D. Purmessur, J. Iatridis, R. Monsey, 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Assessment of functional and behavioral changes sensitive to painful disc degeneration

Samuel K. Cho, A. Lai, B. Winkelstein, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Notochordal Cell-Derived Therapeutic Strategies for Discogenic Back Pain

D. Purmessur, J. Iatridis, M. Cornejo, 2013, Global spine journal.

High fat diet causes inferior vertebral structure and function without disc degeneration in RAGE‐KO mice

A. Lai, D. Vashishth, J. Iatridis, 2021, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Mechanisms and clinical implications of intervertebral disc calcification

J. Iatridis, F. Mwale, M. Tryfonidou, 2022, Nature Reviews Rheumatology.

Genipin-crosslinked fibrin seeded with oxidized alginate microbeads as a novel composite biomaterial strategy for intervertebral disc cell therapy.

J. Iatridis, A. Hecht, D. Laudier, 2022, Biomaterials.

Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape

J. Iatridis, M. Oyen, N. Nowlan, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model

A. Lai, J. Iatridis, S. Illien-Jünger, 2019, bioRxiv.

Bone matrix quality in a developing high-fat diet mouse model is altered by RAGE deletion.

Samuel J. Stephen, D. Vashishth, J. Iatridis, 2022, Bone.

Chronic Ingestion of Advanced Glycation End Products Induces Degenerative Spinal Changes and Hypertrophy in Aging Pre-Diabetic Mice

G. Striker, J. Iatridis, A. Hecht, 2015, PloS one.

Mechanical restoration and failure analyses of a hydrogel and scaffold composite strategy for annulus fibrosus repair.

D. Grijpma, P. Zysset, J. Iatridis, 2016, Acta biomaterialia.

Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGF&bgr;3

D. Purmessur, J. Iatridis, D. Laudier, 2013, Journal of spinal disorders & techniques.

Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells

D. Purmessur, J. Iatridis, K. Godburn, 2011, Arthritis research & therapy.

Loss of tenomodulin expression is a risk factor for age‐related intervertebral disc degeneration

D. Docheva, H. Clausen‐Schaumann, P. Alberton, 2020, Aging cell.

Hydrogel-Embedded Poly(Lactic-co-Glycolic Acid) Microspheres for the Delivery of hMSC-Derived Exosomes to Promote Bioactive Annulus Fibrosus Repair

R. Davé, Minghui Wang, J. Iatridis, 2022, Cartilage.

Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment

A. Lai, J. Iatridis, N. Karabul, 2014, PloS one.

Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses

A. Lai, G. Striker, J. Iatridis, 2013, PloS one.

A perspective on the ORS Spine Section initiative to develop a multi‐species JOR Spine histopathology series

J. Lotz, A. Lai, C. Séguin, 2021, JOR spine.

Stress and matrix‐responsive cytoskeletal remodeling in fibroblasts

J. Iatridis, H. Langevin, Cathryn Koptiuch, 2013, Journal of cellular physiology.

Ex-vivo biomechanics of repaired rat intervertebral discs using genipin crosslinked fibrin adhesive hydrogel.

A. Lai, J. Iatridis, A. Hecht, 2020, Journal of biomechanics.

Commentary: Does needle injection cause disc degeneration? News in the continuing debate regarding pathophysiology associated with intradiscal injections.

J. Iatridis, A. Hecht, 2012, The spine journal : official journal of the North American Spine Society.

Elevated glycohemoglobin HbA1c is associated with low back pain in nonoverweight diabetics.

Samuel K. Cho, J. Iatridis, A. Hecht, 2019, The spine journal : official journal of the North American Spine Society.

Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration.

Benjamin A Walter, J. Iatridis, B. Walter, 2017, The spine journal : official journal of the North American Spine Society.

Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment

Samuel K. Cho, James D. Kang, M. Risbud, 2019, JBMR plus.

The Functional Role of Interface Tissue Engineering in Annulus Fibrosus Repair: Bridging Mechanisms of Hydrogel Integration with Regenerative Outcomes.

J. Iatridis, T. DiStefano, G. Danias, 2020, ACS biomaterials science & engineering.

Biomechanical test protocols to detect minor injury effects in intervertebral discs.

O. M. Torre, J. Iatridis, P. Nasser, 2019, Journal of the mechanical behavior of biomedical materials.

LIST OF ABBREVIATIONS AF : Annulus Fibrosus ADAMTS : A Disintegrin And Metalloproteinase with Thrombospondin Motifs

D. Kletsas, M. Risbud, J. Hoyland, 2016 .

Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N‐cadherin expression

D. Purmessur, J. Iatridis, D. Laudier, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Hyperosmolarity Induces Notochordal Cell Differentiation with Aquaporin 3 Upregulation and Reduced N-cadherin Expression † Running Title : Effects of Osmolarity on Nucleus Pulposus Maturation

D. Purmessur, J. Iatridis, D. Laudier, 2017 .

Single‐cell RNA‐sequencing atlas of bovine caudal intervertebral discs: Discovery of heterogeneous cell populations with distinct roles in homeostasis

R. Sebra, Arpit Dave, J. Iatridis, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Spatial mapping of collagen content and structure in human intervertebral disk degeneration

J. Iatridis, D. Laudier, J. Poeran, 2020, JOR spine.

Extracellular Vesicles as an Emerging Treatment Option for Intervertebral Disc Degeneration: Therapeutic Potential, Translational Pathways, and Regulatory Considerations

J. Iatridis, T. DiStefano, G. Danias, 2021, Advanced healthcare materials.

SHORT-TERM FOETAL IMMOBILITY TEMPORALLY AND PROGRESSIVELY AFFECTS CHICK SPINAL CURVATURE AND ANATOMY AND RIB DEVELOPMENT

Y. Huang, J. Iatridis, N. Nowlan, 2019, European cells & materials.

Males and females exhibit distinct relationships between intervertebral disc degeneration and pain in a rat model

Daniel A. Charen, Bin Zhang, A. Lai, 2020, Scientific Reports.

Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice

A. Lai, E. Bradley, J. Westendorf, 2019, Cell Death & Disease.

Dietary Advanced Glycation End Products Have Sex‐ and Age‐Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice

Deepak Vashishth, D. Vashishth, J. Iatridis, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Do mechanical strain and TNF-α interact to amplify pro-inflammatory cytokine production in human annulus fibrosus cells?

O. M. Torre, J. Iatridis, A. Hecht, 2016, Journal of biomechanics.

Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug.

O. M. Torre, J. Iatridis, Zepur Kazezian, 2015, The spine journal : official journal of the North American Spine Society.

Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair

J. Iatridis, A. Hecht, B. Walter, 2014 .

Harmonization and standardization of nucleus pulposus cell extraction and culture methods

L. Setton, P. Kraus, T. Lufkin, 2023, JOR spine.

Genetic polymorphisms associated with intervertebral disc degeneration.

James C. Iatridis, Omri Gottesman, O. Gottesman, 2013, The spine journal : official journal of the North American Spine Society.

Association Between BMP-2 and Carcinogenicity

Samuel K. Cho, P. Anderson, J. Iatridis, 2015, Spine.

Neonatal annulus fibrosus regeneration occurs via recruitment and proliferation of Scleraxis-lineage cells

O. M. Torre, A. Huang, J. Iatridis, 2019, npj Regenerative Medicine.

Composite biomaterial repair strategy to restore biomechanical function and reduce herniation risk in an ex vivo large animal model of intervertebral disc herniation with varying injury severity

J. Iatridis, A. Hecht, D. Laudier, 2019, PloS one.

Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – An In Vivo Rat Model

A. Lai, A. Seifert, J. Iatridis, 2023, bioRxiv.

Outcomes and Complications of Diabetes Mellitus on Patients Undergoing Degenerative Lumbar Spine Surgery

Samuel K. Cho, J. Iatridis, A. Hecht, 2014, Spine.

Physician Decision-making in Return to Play After Cervical Spine Injury

J. Iatridis, A. Hecht, C. Ukogu, 2020, Clinical spine surgery.

Measuring the neutral zone of spinal motion segments: Comparison of multiple analysis methods to quantify spinal instability

O. M. Torre, J. Iatridis, P. Nasser, 2020, JOR spine.

Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration

A. Lai, J. Iatridis, D. Laudier, 2023, International journal of molecular sciences.

Ex vivo biomechanical evaluation of Acute lumbar endplate injury and comparison to annulus fibrosus injury in a rat model.

A. Lai, J. Iatridis, D. Laudier, 2022, Journal of the mechanical behavior of biomedical materials.

Sex Differences in Rat Intervertebral Disc Structure and Function Following Annular Puncture Injury.

A. Lai, J. Iatridis, P. Nasser, 2019, Spine.

Inhibiting tumor necrosis factor‐alpha at time of induced intervertebral disc injury limits long‐term pain and degeneration in a rat model

Beth A Winkelstein, Samuel K. Cho, Alon Lai, 2018, JOR spine.

Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain

A. Lai, J. Iatridis, Thomas W Evashwick-Rogler, 2017, Annals of the New York Academy of Sciences.

Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo.

Samuel K. Cho, A. Lai, B. Winkelstein, 2016, The spine journal : official journal of the North American Spine Society.

New horizons in spine research: Intervertebral disc repair and regeneration

R. Kandel, M. Risbud, J. Iatridis, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration

D. Docheva, O. M. Torre, J. Iatridis, 2021, Cartilage.

The importance of diversity, equity, and inclusion in orthopedic research

C. Rimnac, R. Queen, J. Westendorf, 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Injectable cellulose-based hydrogels as nucleus pulposus replacements: Assessment of in vitro structural stability, ex vivo herniation risk, and in vivo biocompatibility.

R. Phelps, J. Iatridis, P. Nasser, 2019, Journal of the mechanical behavior of biomedical materials.

Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair.

O. M. Torre, J. Iatridis, R. Long, 2016, Journal of biomechanical engineering.

TNFα Transport Induced by Dynamic Loading Alters Biomechanics of Intact Intervertebral Discs

James C. Iatridis, Benjamin A. Walter, P. Roughley, 2015, PloS one.

TNF alpha Transport Induced by Dynamic Loading Alters Biomechanics of Intact Intervertebral Discs

P. Roughley, J. Iatridis, A. Hecht, 2022 .

Structural, compositional, and biomechanical alterations of the lumbar spine in rats with mucopolysaccharidosis type VI (Maroteaux–Lamy syndrome)

A. Lai, J. Iatridis, D. Laudier, 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Trends in Bone Morphogenetic Protein Usage since the U.S. Food and Drug Administration Advisory in 2008: What Happens to Physician Practices When the Food and Drug Administration Issues an Advisory?

Samuel K. Cho, J. Iatridis, A. Hecht, 2013, Global spine journal.

Does BMP-2 Really Cause Cancer? A Systematic Review of the Literature

Samuel K. Cho, D. Purmessur, J. Iatridis, 2012 .

Development of a two-part biomaterial adhesive strategy for annulus fibrosus repair and ex vivo evaluation of implant herniation risk.

J. Iatridis, A. Hecht, D. Laudier, 2020, Biomaterials.

In vitro and biomechanical screening of polyethylene glycol and poly(trimethylene carbonate) block copolymers for annulus fibrosus repair

D. Grijpma, J. Iatridis, R. Long, 2018, Journal of tissue engineering and regenerative medicine.

Cellular bone matrices: viable stem cell-containing bone graft substitutes.

Samuel K. Cho, J. Iatridis, B. Skovrlj, 2014, The spine journal : official journal of the North American Spine Society.

The Impact of Diabetes Mellitus on Patients Undergoing Degenerative Cervical Spine Surgery

Samuel K. Cho, J. Iatridis, A. Hecht, 2014, Spine.

Ingenuity during the COVID-19 pandemic: a controlled experiment for respirator mask efficacy testing

Daniel A. Charen, L. Galatz, Danil Rybalko, 2020, BMJ Innovations.

Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks.

J. Iatridis, D. Eglin, A. Hecht, 2017, Journal of biomechanical engineering.

Neonatal annulus fibrosus regeneration occurs via recruitment and proliferation of Scleraxis-lineage cells

O. M. Torre, A. Huang, J. Iatridis, 2019, npj Regenerative Medicine.

Development of a bovine decellularized extracellular matrix‐biomaterial for nucleus pulposus regeneration

J. Iatridis, A. Hecht, S. Qureshi, 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Accelerometry Data Delineates Phases of Recovery and Supplements Patient-Reported Outcome Measures Following Lumbar Laminectomy.

J. Iatridis, A. Hecht, J. Poeran, 2022, World Neurosurgery.

Nonoperative Management of Discogenic Back Pain: A Systematic Review

Samuel K. Cho, D. Purmessur, J. Iatridis, 2014, Spine.

Erratum: Combined anti-inflammatory and anti-age drug treatments have a protective effect on intervertebral discs in mice with diabetes (PLoS ONE (2013) 8:5 (e64302) doi:10.1371/journal.pone.0064302)

G. Striker, J. Iatridis, S. Illien-Jünger, 2015 .

Morphological and biomechanical effects of annulus fibrosus injury and repair in an ovine cervical model

D. Grijpma, S. Ferguson, D. Sakai, 2019, JOR spine.

Effects of Level, Loading Rate, Injury and Repair on Biomechanical Response of Ovine Cervical Intervertebral Discs

S. Ferguson, M. Alini, S. Grad, 2018, Annals of Biomedical Engineering.

Effects of Torsion on Intervertebral Disc Gene Expression and Biomechanics, Using a Rat Tail Model

A. Lai, J. Iatridis, K. Godburn, 2011, Spine.

Galectin‐3 and RAGE differentially control advanced glycation endproduct‐induced collagen damage in murine intervertebral disc organ culture

J. Iatridis, D. Laudier, P. Nasser, 2023, JOR spine.

Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization - An In Vivo Rat Model.

A. Lai, A. Seifert, J. Iatridis, 2023, The spine journal : official journal of the North American Spine Society.

Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration

J. Antoniou, J. Iatridis, F. Mwale, 2013, Journal of magnetic resonance imaging : JMRI.

New Horizons in Spine Research: Disc biology, spine biomechanics and pathomechanisms of back pain

R. Kandel, M. Risbud, J. Iatridis, 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Advancing basic and preclinical spine research: Highlights from the ORS PSRS 5th International Spine Research Symposium

J. Iatridis, Lachlan J. Smith, C. Dahia, 2020, JOR spine.

Characterization of mechanics and cytocompatibility of fibrin-genipin annulus fibrosus sealant with the addition of cell adhesion molecules.

D. Purmessur, O. M. Torre, J. Iatridis, 2014, Tissue Engineering. Part A.

A Method for Characterising Human Intervertebral Disc Glycosaminoglycan Disaccharides using Liquid Chromatography-Mass Spectrometry with Multiple Reaction Monitoring

J. Iatridis, R. Linhardt, J. Iatridis, 2018, European cells & materials.

Challenges and strategies in the repair of ruptured annulus fibrosus.

D. Grijpma, S. Ferguson, D. Sakai, 2013, European cells & materials.