Lachlan J. Smith

发表

Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model.

Dong Hwa Kim, A. Milby, D. Elliott, 2014, Acta biomaterialia.

In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus.

Brent L. Showalter, D. Elliott, E. Beattie, 2014, Tissue engineering. Part A.

Needle puncture injury causes acute and long‐term mechanical deficiency in a mouse model of intervertebral disc degeneration

B. Harfe, D. Elliott, E. Beattie, 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Degeneration and regeneration of the intervertebral disc: lessons from development

B. Harfe, D. Elliott, Lachlan J. Smith, 2010, Disease Models & Mechanisms.

Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section

C. T. Buckley, J. Lotz, C. L. Le Maitre, 2018, JOR spine.

* Optimization of Preculture Conditions to Maximize the In Vivo Performance of Cell-Seeded Engineered Intervertebral Discs.

Dong Hwa Kim, D. Elliott, Harvey E. Smith, 2017, Tissue engineering. Part A.

Surgical Approaches for the Treatment of Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: Results of a Decision Analysis.

A. Milby, S. Stein, N. Malhotra, 2018, World neurosurgery.

Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model.

Dawn M. Elliott, Robert L. Mauck, Thomas P. Schaer, 2017, Acta biomaterialia.

Elastic Fibers Enhance the Mechanical Integrity of the Human Lumbar Anulus Fibrosus in the Radial Direction

John J. Costi, Nicola L. Fazzalari, J. Costi, 2008, Annals of Biomedical Engineering.

Regional variations in the density and arrangement of elastic fibres in the anulus fibrosus of the human lumbar disc

Lachlan J. Smith, N. Fazzalari, 2006, Journal of anatomy.

Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model

Yejia Zhang, Lachlan J. Smith, R. Mauck, 2017, American journal of physical medicine & rehabilitation.

Oxidative DNA damage in gestational diabetes Mellitus: Correlation with Antioxidants in an Iraqi Cohort

H. Jelinek, Lachlan J. Smith, H. Al-Aubaidy, 2014 .

Multi-scale Structural and Tensile Mechanical Response of Annulus Fibrosus to Osmotic Loading

N. Jacobs, D. Elliott, Lachlan J. Smith, 2012, Annals of Biomedical Engineering.

Effect of orientation and targeted extracellular matrix degradation on the shear mechanical properties of the annulus fibrosus.

N. Jacobs, D. Elliott, J. Yoder, 2011, Journal of the mechanical behavior of biomedical materials.

The role of mineral content in determining the micromechanical properties of discrete trabecular bone remodeling packets.

Lachlan J. Smith, N. Fazzalari, J. Schirer, 2010, Journal of biomechanics.

Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage.

D. Elliott, R. Duncan, Lachlan J. Smith, 2016, Nature materials.

Ultrastructural analysis of different skeletal cell types in mucopolysaccharidosis dogs at the onset of postnatal growth

Lachlan J. Smith, M. Casal, Zhirui Jiang, 2020, Journal of anatomy.

MRI quantification of human spine cartilage endplate geometry: Comparison with age, degeneration, level, and disc geometry

A. Wright, D. Elliott, E. Vresilovic, 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Intervertebral disc development and disease-related genetic polymorphisms

H. An, Yejia Zhang, Lachlan J. Smith, 2016, Genes & diseases.

In vitro evaluation of a manganese chloride phantom-based MRI technique for quantitative determination of lumbar intervertebral disc composition and condition

A. Kurmis, Lachlan J. Smith, N. Fazzalari, 2011, European Spine Journal.

Fabrication, Maturation, and Implantation of Composite Tissue-Engineered Total Discs Formed from Native and Mesenchymal Stem Cell Combinations.

Dong Hwa Kim, D. Elliott, Harvey E. Smith, 2020, Acta biomaterialia.

Hypoxic Preconditioning Enhances Bone Marrow–Derived Mesenchymal Stem Cell Survival in a Low Oxygen and Nutrient-Limited 3D Microenvironment

J. Tobias, G. R. Dodge, N. Malhotra, 2019, Cartilage.

Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture.

D. Elliott, G. R. Dodge, J. Chiaro, 2011, European cells & materials.

Effect of neonatal gene therapy on lumbar spine disease in mucopolysaccharidosis VII dogs.

D. Elliott, John T. Martin, Lachlan J. Smith, 2012, Molecular genetics and metabolism.

Progression of vertebral bone disease in mucopolysaccharidosis VII dogs from birth to skeletal maturity.

Lachlan J. Smith, M. Haskins, M. Casal, 2021, Molecular genetics and metabolism.

Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate Severity Disc Degeneration in Goats.

D. Elliott, G. R. Dodge, Weiliam Chen, 2020, Tissue engineering. Part A.

Hypoxic regulation of functional extracellular matrix elaboration by nucleus pulposus cells in long‐term agarose culture

D. Elliott, G. R. Dodge, N. Malhotra, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation

D. Elliott, G. R. Dodge, N. Malhotra, 2014, Journal of Experimental Orthopaedics.

Oxidative DNA Damage inGestational Diabetes Mellitus: Correlation withAntioxidantsin an IraqiCohort

Lachlan J. Smith, H. Al-Aubaidy, D. Jamil, 2014 .

An unusual MR signal reduction artefact in an incompletely thawed cadaver spine specimen

A. Kurmis, Lachlan J. Smith, N. Fazzalari, 2009 .

Proteomics identifies novel biomarkers of synovial joint disease in a canine model of mucopolysaccharidosis I.

G. R. Dodge, H. Fazelinia, R. Gawri, 2023, Molecular genetics and metabolism.

Pathogenesis and treatment of spine disease in the mucopolysaccharidoses.

Can Ficicioglu, N. Malhotra, Lachlan J. Smith, 2016, Molecular genetics and metabolism.

Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc

C. L. Le Maitre, S. Grad, D. Purmessur, 2022, JOR spine.

Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs

N. Malhotra, J. Chiaro, Lachlan J. Smith, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Failures of Endochondral Ossification in the Mucopolysaccharidoses

Lachlan J. Smith, M. Casal, S. Byers, 2020, Current Osteoporosis Reports.

Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs

Lachlan J. Smith, M. Haskins, E. Schuchman, 2016, PloS one.

Mechanical properties of the extra‐fibrillar matrix of human annulus fibrosus are location and age dependent

D. Elliott, Lachlan J. Smith, D. Cortes, 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Phenotypic stability, matrix elaboration and functional maturation of nucleus pulposus cells encapsulated in photocrosslinkable hyaluronic acid hydrogels.

Dong Hwa Kim, Dawn M Elliott, Robert L Mauck, 2015, Acta biomaterialia.

Cell therapy for the degenerating intervertebral disc.

Robert L Mauck, Harvey E. Smith, N. Malhotra, 2017, Translational research : the journal of laboratory and clinical medicine.

Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus

J. Tobias, B. Harfe, N. Malhotra, 2017, Scientific Reports.

The elastic fibre network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration

Lachlan J. Smith, N. Fazzalari, 2009, European Spine Journal.

RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues

M. Yaszemski, A. V. van Wijnen, M. Bydon, 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Hemorrhage into Synovial Cysts as a Cause of Acute Radicular Symptoms: Report of Seven Cases and Review of the Literature

W. Welch, B. Winkelstein, Lachlan J. Smith, 2013 .

Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging

A. Wright, D. Elliott, J. Yoder, 2013, European Spine Journal.

A comprehensive tool box for large animal studies of intervertebral disc degeneration

H. Wilke, Keita Ito, S. Grad, 2021, JOR spine.

Bone Remodeling and Disc Morphology in the Distal Unfused Spine After Spinal Fusion in Adolescent Idiopathic Scoliosis

Lachlan J. Smith, S. Pasha, W. Sankar, 2019, Spine deformity.

Altered lumbar spine structure, biochemistry, and biomechanical properties in a canine model of mucopolysaccharidosis type VII

Spencer E. Szczesny, D. Elliott, John T. Martin, 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Molecular profiling of failed endochondral ossification in mucopolysaccharidosis VII.

J. Tobias, N. Malhotra, Lachlan J. Smith, 2019, Bone.

Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs.

G. R. Dodge, N. Malhotra, Lachlan J. Smith, 2015, Molecular genetics and metabolism.

Delayed Chondrocyte Differentiation and Altered Indian Hedgehog Signaling Contribute to Failed Vertebral Bone Formation in Mucopolysaccharidosis VII

J. Chiaro, Lachlan J. Smith, M. Haskins, 2014 .

Pathogenesis of lumbar spine disease in mucopolysaccharidosis VII.

D. Elliott, Lachlan J. Smith, R. Giugliani, 2012, Molecular genetics and metabolism.

Postnatal progression of bone disease in the cervical spines of mucopolysaccharidosis I dogs.

D. Elliott, J. Chiaro, Lachlan J. Smith, 2013, Bone.

Oral manifestations in patients and dogs with mucopolysaccharidosis Type VII

P. Tanpaiboon, S. Nampoothiri, Lachlan J. Smith, 2019, American journal of medical genetics. Part A.

INFLAMMATORY RESPONSE TO DIABETIC MEDICATIONS IN PATIENTS WITH AND WITHOUT DIABETIC NEPHROPATHY

Lachlan J. Smith, N. Hadi, H. Al-Aubaidy, 2014 .

Inflammatory cytokine and catabolic enzyme expression in a goat model of intervertebral disc degeneration

D. Elliott, G. R. Dodge, N. Malhotra, 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Correlations between quantitative T2 and T1ρ MRI, mechanical properties and biochemical composition in a rabbit lumbar intervertebral disc degeneration model

Harvey E. Smith, John T. Martin, Lachlan J. Smith, 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc

Dong Hwa Kim, D. Elliott, Harvey E. Smith, 2018, Science Translational Medicine.

Promise, progress, and problems in whole disc tissue engineering

Harvey E. Smith, Lachlan J. Smith, R. Mauck, 2018, JOR spine.

Towards the scale up of tissue engineered intervertebral discs for clinical application.

Dong Hwa Kim, D. Elliott, Harvey E. Smith, 2018, Acta biomaterialia.

Bullying, harassment, and discrimination of musculoskeletal researchers and the impact of the COVID-19 pandemic: an international study

A. Fields, C. L. Le Maitre, M. Giers, 2023, European Spine Journal.

IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro

Dawn M Elliott, Robert L Mauck, Bhavana Mohanraj, 2012, Arthritis Research & Therapy.

Multi-scale Structural and Tensile Mechanical Response of Annulus Fibrosus to Osmotic Loading

N. Jacobs, D. Elliott, Lachlan J. Smith, 2012, Annals of Biomedical Engineering.

Macro- to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific.

Dawn M Elliott, Robert L Mauck, Su-Jin Heo, 2013, Biophysical journal.

Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration

N. Malhotra, Yejia Zhang, Lachlan J. Smith, 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Impact of Reduced Preincision Antibiotic Infusion Time on Surgical Site Infection Rates: A Retrospective Cohort Study.

M. Grady, N. Malhotra, Lachlan J. Smith, 2020, Annals of surgery.

Formation of lamellar cross bridges in the annulus fibrosus of the intervertebral disc is a consequence of vascular regression.

D. Elliott, Lachlan J. Smith, 2011, Matrix biology : journal of the International Society for Matrix Biology.

Epiphyseal cartilage canal architecture and extracellular matrix remodeling in mucopolysaccharidosis VII dogs at the onset of postnatal growth

M. Nissi, C. P. Johnson, Lachlan J. Smith, 2020, Connective tissue research.

Association of Surgical Overlap during Wound Closure with Patient Outcomes among Neurological Surgery Patients at a Large Academic Medical Center.

John Y. K. Lee, A. Ramayya, N. Malhotra, 2019, Neurosurgery.

In vivo performance of an acellular disc‐like angle ply structure (DAPS) for total disc replacement in a small animal model

Dong Hwa Kim, A. Milby, D. Elliott, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Microstructural Heterogeneity in Native and Engineered Fibrocartilage Directs Micromechanics and Mechanobiology

Claire M. McLeod, D. Elliott, R. Duncan, 2015, Nature materials.

Advancing basic and preclinical spine research: Highlights from the ORS PSRS 5th International Spine Research Symposium

J. Iatridis, Lachlan J. Smith, C. Dahia, 2020, JOR spine.

Recapitulating the Spectrum of Intervertebral Disc Degeneration in a Large Animal Model

A. Milby, D. Elliott, E. Vresilovic, 2016 .

Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus

N. Malhotra, Lachlan J. Smith, R. Mauck, 2023, bioRxiv.

Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus

J. Tobias, B. Harfe, N. Malhotra, 2017, Scientific Reports.

Functional consequences of glucose and oxygen deprivation on engineered mesenchymal stem cell-based cartilage constructs.

Lachlan J. Smith, R. Mauck, M. Farrell, 2015, Osteoarthritis and cartilage.

Postnatal progression of bone disease in the cervical spines of mucopolysaccharidosis I dogs.

D. Elliott, J. Chiaro, Lachlan J. Smith, 2013, Bone.

Degeneration and regeneration of the intervertebral disc: lessons from development

B. Harfe, D. Elliott, Lachlan J. Smith, 2010, Disease Models & Mechanisms.

Needle puncture injury causes acute and long‐term mechanical deficiency in a mouse model of intervertebral disc degeneration

B. Harfe, D. Elliott, E. Beattie, 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

In Vitro Maturation and In Vivo Integration and Function of an Engineered Cell-Seeded Disc-like Angle Ply Structure (DAPS) for Total Disc Arthroplasty

D. Elliott, Lachlan J. Smith, R. Mauck, 2017, Scientific Reports.

Cell therapy for the degenerating intervertebral disc.

Harvey E. Smith, N. Malhotra, Yejia Zhang, 2017, Translational research : the journal of laboratory and clinical medicine.

Micromechanical properties of human trabecular bone: a hierarchical investigation using nanoindentation.

J. Shapter, K. Short, Lachlan J. Smith, 2008, Journal of biomedical materials research. Part A.

Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model.

D. Elliott, G. R. Dodge, Weiliam Chen, 2017, Acta biomaterialia.