H. Gruber

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Senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2010, BMC biotechnology.

Do We Need Biomarkers for Disc Degeneration?

H. Gruber, E. Hanley, 2006, Biomarker insights.

Osteogenic, stem cell and molecular characterisation of the human induced membrane from extremity bone defects

M. Bosse, H. Gruber, J. Ingram, 2016, Bone & joint research.

Computer aided vertebral visualization and analysis: a methodology using the sand rat, a small animal model of disc degeneration

Kayvan Najarian, K. Najarian, H. Gruber, 2003, BMC musculoskeletal disorders.

Inching our way up Mount Olympus: The evolving-systems approach to creative thinking.

H. Gruber, S. Davis, 1988 .

Growth and differentiation factor-5 (GDF-5) in the human intervertebral annulus cells and its modulation by IL-1ß and TNF-α in vitro.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2014, Experimental and molecular pathology.

Anti-Apoptotic Effects of IGF-1 and PDGF on Human Intervertebral Disc Cells In Vitro

H. Gruber, E. Hanley, H. Norton, 2000, Spine.

Internalization of bacteria by osteoblasts in a patient with recurrent, long-term osteomyelitis. A case report.

M. Bosse, H. Gruber, W. K. Ramp, 2005, The Journal of bone and joint surgery. American volume.

Clinical Studies Leptin expression by annulus cells in the human intervertebral disc

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2007 .

Leptin expression by annulus cells in the human intervertebral disc.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2007, The spine journal : official journal of the North American Spine Society.

Calcium deposition in osteoarthritic meniscus and meniscal cell culture

Yubo Sun, H. Gruber, N. Zinchenko, 2010, Arthritis research & therapy.

Recent Advances in Disc Cell Biology

H. Gruber, E. Hanley, 2003, Spine.

Comparison of Human Osteoblasts and Osteogenic Cells from Heterotopic Bone

H. Gruber, G. Lang, W. K. Ramp, 1997, Clinical orthopaedics and related research.

The SOX9 Transcription Factor in the Human Disc: Decreased Immunolocalization With Age and Disc Degeneration

H. Gruber, J. Ingram, E. Hanley, 2005, Spine.

Alterations in growth plate and articular cartilage morphology are associated with reduced SOX9 localization in the magnesium-deficient rat

H. Gruber, J. Ingram, H. Norton, 2004, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Biologic strategies for the therapy of intervertebral disc degeneration

H. Gruber, Edward N Hanley Jr, 2003, Expert opinion on biological therapy.

Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism

H. Gruber, H. Norton, R. Rude, 2006, Osteoporosis International.

Cell-based tissue engineering for the intervertebral disc: in vitro studies of human disc cell gene expression and matrix production within selected cell carriers.

H. Gruber, J. Ingram, E. Hanley, 2004, The spine journal : official journal of the North American Spine Society.

Cell‐based tissue engineering augments tendon‐to‐bone healing in a rat supraspinatus model

H. Gruber, Gretchen L. Hoelscher, E. Hanley, 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Micromass Culture of Human Anulus Cells: Morphology and Extracellular Matrix Production

Yubo Sun, H. Gruber, Gretchen L. Hoelscher, 2010, Spine.

Open Access

Yubo Sun, H. Gruber, Gretchen L. Hoelscher, 2023, Oral Surgery.

1,25(OH)2-Vitamin D3 Inhibits Proliferation and Decreases Production of Monocyte Chemoattractant Protein-1, Thrombopoietin, VEGF, and Angiogenin by Human Annulus Cells In Vitro

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2008, Spine.

Three-dimensional culture of human meniscal cells: Extracellular matrix and proteoglycan production

Yubo Sun, H. Gruber, J. Ingram, 2008, BMC biotechnology.

Cell Polarity in the Anulus of the Human Intervertebral Disc: Morphologic, Immunocytochemical, and Molecular Evidence

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2007, Spine.

Current Perspectives on Biologic Strategies for the Therapy of Intervertebral Disc Degeneration

H. Gruber, E. Hanley, 2007 .

Immunolocalization of Thrombospondin in the Human and Sand Rat Intervertebral Disc

H. Gruber, J. Ingram, E. Hanley, 2006, Spine.

Cellular immunohistochemical localization of the matricellular protein myocilin in the intervertebral disc

H. Gruber, J. Ingram, En Hanley Jr, 2006, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Colony Formation and Matrix Production by Human Anulus Cells: Modulation in Three-dimensional Culture

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2004, Spine.

Characterization and phenotypic stability of human disc cells in vitro.

H. Gruber, E. Hanley, A. A. Stasky, 1997, Matrix biology : journal of the International Society for Matrix Biology.

The influence of Matrigel or growth factor reduced Matrigel on human intervertebral disc cell growth and proliferation.

H. Gruber, E. Hanley, B. Desai, 1999, Histology and histopathology.

Human disc cells in monolayer vs 3D culture: cell shape, division and matrix formation

H. Gruber, E. Hanley, 2000, BMC musculoskeletal disorders.

Morphologic and molecular evidence for gap junctions and connexin 43 and 45 expression in annulus fibrosus cells from the human intervertebral disc

H. Gruber, J. Ingram, E. Hanley, 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Autologous Intervertebral Disc Cell Implantation: A Model Using Psammomys obesus, the Sand Rat

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2002, Spine.

Deleterious effects of discography radiocontrast solution on human annulus cell in vitro: changes in cell viability, proliferation, and apoptosis in exposed cells.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2011, The spine journal : official journal of the North American Spine Society.

The chemokine, CXCL16, and its receptor, CXCR6, are constitutively expressed in human annulus fibrosus and expression of CXCL16 is up-regulated by exposure to IL-1ß in vitro

H. Gruber, J. Ingram, E. Hanley, 2017, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Constitutive expression of IL-22 in the human intervertebral disc and its reduction by exposure to pro-inflammatory cytokines in vitro

H. Gruber, J. Ingram, E. Hanley, 2017, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Proinflammatory cytokines modulate the chemokine CCL2 (MCP-1) in human annulus cells in vitro: CCL2 expression and production.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2015, Experimental and molecular pathology.

Proinflammatory Cytokines IL-1&bgr; and TNF-&agr; Influence Human Annulus Cell Signaling Cues for Neurite Growth: In Vitro Coculture Studies

H. Gruber, E. Hanley, E. Marrero, 2017, Spine.

Human annulus signaling cues for nerve outgrowth: In vitro studies

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Senescence in Cells of the Aging and Degenerating Intervertebral Disc: Immunolocalization of Senescence-Associated &bgr;-Galactosidase in Human and Sand Rat Discs

H. Gruber, J. Ingram, E. Hanley, 2007, Spine.

Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus.

H. Gruber, J. Ingram, E. Hanley, 2009, The spine journal : official journal of the North American Spine Society.

Alkaline and acid phosphatase demonstration in human bone and cartilage: effects of fixation interval and methacrylate embedments.

D. Rimoin, H. Gruber, G. Marshall, 1988, Stain technology.

Magnesium Deficiency: Effect on Bone and Mineral Metabolism in the Mouse

H. Gruber, R. Rude, L. Wei, 2002, Calcified Tissue International.

Mitochondrial Membrane Potential and Nuclear and Gene Expression Changes During Human Disc Cell Apoptosis: In Vitro and In Vivo Annulus Findings

H. Gruber, Gretchen L. Hoelscher, E. Hanley, 2015, Spine.

Osteogenic and chondrogenic potential of biomembrane cells from the PMMA‐segmental defect rat model

M. Bosse, H. Gruber, Gretchen L. Hoelscher, 2012, Journal of Orthopaedic Research.

Exogenous thymosin β4 prevents apoptosis in human intervertebral annulus cells in vitro

H. Gruber, J. Ingram, E. Hanley, 2009, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Diagnosis of osteoporosis

H. Gruber, D. Baylink, H. Genant, 2013 .

CXC receptor knockout mice: characterization of skeletal features and membranous bone healing in the adult mouse.

H. Gruber, K. Ishida, D. Yamaguchi, 2011, Bone.

TNFα receptor knockout in mice reduces adverse effects of magnesium deficiency on bone

D. Dempster, H. Gruber, R. Rude, 2009, Growth factors.

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease.

D. Dempster, Hua Zhou, M. Subler, 2007, The Journal of clinical investigation.

Bone loss induced by dietary magnesium reduction to 10% of the nutrient requirement in rats is associated with increased release of substance P and tumor necrosis factor-alpha.

H. Gruber, H. Norton, R. Rude, 2004, The Journal of nutrition.

Magnesium Deficiency Induces Bone Loss in the Rat

H. Gruber, R. Rude, M. Meyer, 1998, Mineral and Electrolyte Metabolism.

Osteoblast Numbers After Calcitonin Therapy: A Retrospective Study of Paired Biopsies Obtained During Long-Term Calcitonin Therapy in Postmenopausal Osteoporosis

H. Gruber, J. Grigsby, Iii C. H. Chesnut, 2000, Calcified Tissue International.

Alterations in osteoclast morphology following long-term 17beta-estradiol administration in the mouse

I. Puzanov, H. Gruber, M. Bennett, 2001, BMC Cell Biology.

In vivo Morphologic Changes in the Rat Osteoclast Induced by Gallium Nitrate: The Result of Toxicity or Other Effects?

H. Gruber, F. Singer, H. Norton, 1999, Mineral and Electrolyte Metabolism.

Breast cancer-associated metastasis is significantly increased in a model of autoimmune arthritis

H. Gruber, P. Mukherjee, Jorge L Schettini, 2008, Breast Cancer Research.

Basic Staining Techniques for Cartilage Sections

H. Gruber, J. Ingram, 2003 .

Basic Staining and Histochemical Techniques and Immunohistochemical Localizations Using Bone Sections

H. Gruber, J. Ingram, 2003 .

Application of stains-all for demarcation of cement lines in methacrylate embedded bone.

H. Gruber, P. Mekikian, 1991, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Demographic factors that influence human disc cell proliferation in vitro.

H. Gruber, E. Hanley, H. Norton, 2006, The spine journal : official journal of the North American Spine Society.

Cellular, but Not Matrix, Immunolocalization of SPARC in the Human Intervertebral Disc: Decreasing Localization With Aging and Disc Degeneration

H. Gruber, J. Ingram, E. Hanley, 2004, Spine.

Mitochondrial bioenergetics, mass, and morphology are altered in cells of the degenerating human annulus

H. Gruber, E. Hanley, H. Norton, 2013, Journal of Orthopaedic Research.

Mitochondrial gene expression in the human annulus: in vivo data from annulus cells and selectively harvested senescent annulus cells.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2011, The spine journal : official journal of the North American Spine Society.

Gene expression of types I, II, and VI collagen, aggrecan, and chondroitin-6-sulfotransferase in the human annulus: in situ hybridization findings.

H. Gruber, J. Ingram, E. Hanley, 2008, The spine journal : official journal of the North American Spine Society.

IGF-1 rescues human intervertebral annulus cells from in vitro stress-induced premature senescence

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2008, Growth factors.

Immunolocalization of MMP-19 in the human intervertebral disc: implications for disc aging and degeneration

H. Gruber, J. Ingram, E. Hanley, 2005, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Cell shape and gene expression in human intervertebral disc cells: in vitro tissue engineering studies

H. Gruber, J. Ingram, H. Norton, 2003, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Tenascin in the human intervertebral disc: alterations with aging and disc degeneration

H. Gruber, J. Ingram, E. Jr, 2002, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Longterm culture of telomerase-transduced rheumatoid arthritis fibroblast-like synoviocytes display a distinct gene expression pattern.

G. Firestein, Yubo Sun, H. Cheung, 2007, The Journal of rheumatology.

Fibroblast-Like Synoviocytes Induce Calcium Mineral Formation and Deposition

Yubo Sun, H. Gruber, N. Zinchenko, 2014, Arthritis.

Telomerase Transduced Osteoarthritis Fibroblast-Like Synoviocytes Display a Distinct Gene Expression Profile

G. Firestein, Yubo Sun, H. Gruber, 2008, The Journal of Rheumatology.

Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2012, Molecular pain.

Effects of surgical approaches for acetabular fractures with associated gluteal vascular injury.

M. Bosse, H. Gruber, S. Sims, 1998, Journal of orthopaedic trauma.

Brachyolmia: radiographic and genetic evidence of heterogeneity.

D. Rimoin, H. Gruber, M. Shohat, 1989, American journal of medical genetics.

Hepatic arterial flow becomes the primary supply of sinusoids following partial portal vein ligation in rats

M. Clemens, H. Gruber, Y. Yokoyama, 2006, Journal of gastroenterology and hepatology.

Thirty Cases of Concurrent Paget's Disease and Primary Hyperparathyroidism: Sex Distribution, Histomorphometry, and Prediction of the Skeletal Response to Parathyroidectomy

H. Gruber, D. Gutteridge, G. K. Worth, 1999, Calcified Tissue International.

Possible heterogeneity in spondyloenchondrodysplasia: quadriparesis, basal ganglia calcifications, and chondrocyte inclusions.

D. Rimoin, M. Frydman, J. Bar-ziv, 1990, American journal of medical genetics.

Matrix metalloproteinase-12 immunolocalization in the degenerating human intervertebral disc and sand rat spine: Biologic implications.

H. Gruber, J. Ingram, E. Hanley, 2014, Experimental and molecular pathology.

Hydrops-ectopic calcification-moth-eaten skeletal dysplasia (Greenberg dysplasia): prenatal diagnosis and further delineation of a rare genetic disorder.

D. Rimoin, D. Chitayat, H. Gruber, 1993, American journal of medical genetics.

A new autosomal recessive lethal chondrodystrophy with congenital hydrops.

D. Rimoin, H. Gruber, C. Greenberg, 1988, American journal of medical genetics.

Targeted Deletion of the SPARC Gene Accelerates Disc Degeneration in the Aging Mouse

E. Sage, H. Gruber, J. Ingram, 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Increased IL-17 expression in degenerated human discs and increased production in cultured annulus cells exposed to IL-1ß and TNF-α

H. Gruber, J. Ingram, E. Hanley, 2013, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Magnesium deficiency and osteoporosis: animal and human observations.

H. Gruber, R. Rude, 2004, The Journal of nutritional biochemistry.

Ultrastructure of inclusion bodies in annulus cells in the degenerating human intervertebral disc

H. Gruber, E. Hanley, En Hanley, 2009, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Crystal deposits in the human intervertebral disc: implications for disc degeneration.

Yubo Sun, H. Gruber, E. Hanley, 2007, The spine journal : official journal of the North American Spine Society.

Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2011, Arthritis research & therapy.

Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2012, Experimental and molecular pathology.

Periostin is expressed by cells of the human and sand rat intervertebral discs

H. Gruber, J. Ingram, N. Zinchenko, 2011, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Maternal and weanling bone: the influence of lowered calcium intake and maternal dietary history.

H. Gruber, S. Stover, 1994, Bone.

Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton

H. Gruber, H. Norton, R. Rude, 2003, BMC musculoskeletal disorders.

Human annulus cells regulate PAPP-A and IGFBP-4 expression, and thereby insulin-like growth factor bioavailability, in response to proinflammatory cytokine exposure in vitro

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2013, Connective tissue research.

Bone and the Immune System

H. Gruber, 1991, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Faculty Opinions recommendation of PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.

H. Gruber, 2006 .

Experimental Induction of Physeal Injuries by Fracture, Drill, and Ablation Techniques: Analyses of Immunohistochemical Findings.

H. Gruber, J. Ingram, J. M. Wattenbarger, 2017, Journal of pediatric orthopedics.

Interleukin-23 is constitutively expressed in the human annulus in vivo and in vitro, and is up-regulated in vitro by TNF-α

H. Gruber, E. Hanley, E. Marrero, 2019, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Production and expression of RANTES (CCL5) by human disc cells and modulation by IL-1-β and TNF-α in 3D culture.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2014, Experimental and molecular pathology.

The Sand Rat (Psammomys obesus obesus) Model of Spontaneous, Age-Related Intervertebral Disc Degeneration

H. Gruber, E. Hanley, 2014 .

Detection of apoptotic cells in vitro: a practical standardized experimental protocol using human fibroblasts for initial laboratory studies.

H. Gruber, G. Hoelscher, A. A. Stasky, 1999, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Immunolocalization of RANKL is Increased and OPG Decreased During Dietary Magnesium Deficiency in the Rat

H. Gruber, R. Rude, A. Frausto, 2005, Nutrition & metabolism.

Alterations in osteoclast morphology following osteoprotegerin administration in the magnesium-deficient mouse

H. Gruber, R. Rude, H. Gruber, 2003, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome. Five patients with features of relapsing polychondritis and Behçet's disease.

G. Firestein, N. Zvaifler, H. Gruber, 1985, The American journal of medicine.

Histological Techniques for Decalcified Bone and Cartilage

Y. An, H. Gruber, Q. Kang, 2003 .

Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1.

H E Gruber, E N Hanley, E. Fisher, 1997, Experimental cell research.

Perinatal lethal hypophosphatasia; Clinical, radiologic and morphologic findings

D. Rimoin, H. Gruber, M. Shohat, 2005, Pediatric Radiology.

Methods for Transmission and Scanning Electron Microscopy of Bone and Cartilage

H. Gruber, Helen E. Gruber, Winston W. Wiggins, 2003 .

Spondylo-meta-epiphyseal dysplasia (SMED), short limb-hand type: a congenital familial skeletal dysplasia with distinctive features and histopathology.

D. Rimoin, H. Gruber, Z. Borochowitz, 1993, American journal of medical genetics.

Safety of Recombinant Human Bone Morphogenetic Protein‐2 After Spinal Laminectomy in the Dog

J. Wozney, H. Gruber, E. Hanley, 1999, Spine.

Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and two carriers.

J. Wozney, H. Gruber, E. Hanley, 1999, Spine.

Genomewide Molecular and Biologic Characterization of Biomembrane Formation Adjacent to a Methacrylate Spacer in the Rat Femoral Segmental Defect Model

M. Bosse, H. Gruber, Gretchen L. Hoelscher, 2013, Journal of orthopaedic trauma.

Principles of Embedding and Common Protocols

P. L. Moreira, Y. An, H. Gruber, 2003 .

Introduction to Experimental Bone and Cartilage Histology

Y. An, H. Gruber, 2003 .

Effect of Interposed Periosteum in an Animal Physeal Fracture Model

H. Gruber, M. Easley, J. M. Wattenbarger, 2000, Clinical orthopaedics and related research.

Utilization of the AO LockingRatNail in a Novel Rat Femur Critical Defect Model

M. Bosse, H. Gruber, J. Kellam, 2012, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

Improvements in dehydration and cement line staining for methacrylate embedded human bone biopsies.

S. Massry, H. Gruber, G. Marshall, 1985, Stain technology.

Skeletal and Hormonal Effects of Magnesium Deficiency

H. Gruber, F. Singer, R. Rude, 2009, Journal of the American College of Nutrition.

Physeal Fractures, Part II: Fate of Interposed Periosteum in a Physeal Fracture

H. Gruber, J. M. Wattenbarger, L. Phieffer, 2002, Journal of pediatric orthopedics.

The Role of the Basement Plate in Physeal Bar Formation

H. Gruber, J. M. Wattenbarger, M. Cox, 2018, Journal of pediatric orthopedics.

Physeal Fractures, Part I: Histologic Features of Bone, Cartilage, and Bar Formation in a Small Animal Model

H. Gruber, J. M. Wattenbarger, L. Phieffer, 2002, Journal of pediatric orthopedics.

Effects of Very High Antibiotic Concentrations on Human Intervertebral Disc Cell Proliferation, Viability, and Metabolism In Vitro

H. Gruber, E. Hanley, J. Grigsby, 2000, Spine.

Dietary magnesium reduction to 25% of nutrient requirement disrupts bone and mineral metabolism in the rat.

H. Gruber, H. Norton, H. Norton, 2005, Bone.

Anti-Apoptotic Actions of Cytokines in Mammalian Cells

H. Gruber, B. Desai, 1999 .

Phosphocitrate Is Potentially a Disease-Modifying Drug for Noncrystal-Associated Osteoarthritis

Yubo Sun, H. Gruber, E. Hanley, 2013, BioMed research international.

Quantitative Histology of Cartilage Cell Columns in the Human Costochondral Junction: Findings in Newborn and Pediatric Subjects

D. Rimoin, H. Gruber, 1989, Pediatric Research.

X-ray and proton induced ultrastructural changes in Chlamydomonas reinhardi, with special reference to the dividing cell

H. Gruber, 1976 .

Adaptations of Goldner's Masson trichrome stain for the study of undecalcified plastic embedded bone.

H. Gruber, Helen E. Gruber, 1992, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

UV-killed Staphylococcus aureus enhances adhesion and differentiation of osteoblasts on bone-associated biomaterials.

H. Gruber, M. Hudson, Y. Huet, 2010, Journal of biomedical materials research. Part A.

Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc?

A. Matta, C. Little, J. Melrose, 2018, Stem cells and development.

Cell cycle dependent x-ray-induced death in Chlamydomonas reinhardi.

H. Gruber, D. Nachtwey, 1976, Radiation research.

Interleukin 1-beta upregulates brain-derived neurotrophic factor, neurotrophin 3 and neuropilin 2 gene expression and NGF production in annulus cells

H. Gruber, G. Hoelscher, S. Bethea, 2012, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Brain-derived neurotrophic factor and its receptor in the human and the sand rat intervertebral disc

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2008, Arthritis research & therapy.

An amino acid substitution (Gly853-->Glu) in the collagen alpha 1(II) chain produces hypochondrogenesis.

D. Rimoin, D. Eyre, H. Gruber, 1992, Journal of Biological Chemistry.

Analysis of Aging and Degeneration of the Human Intervertebral Disc: Comparison of Surgical Specimens With Normal Controls

H E Gruber, E N Hanley, H. Gruber, 1998, Spine.

An RNA-splicing mutation (G+5IVS20) in the type II collagen gene (COL2A1) in a family with spondyloepiphyseal dysplasia congenita.

D. Rimoin, D. Eyre, H. Gruber, 1995, American journal of human genetics.

A large family with features of pseudoachondroplasia and multiple epiphyseal dysplasia: exclusion of seven candidate gene loci that encode proteins of the cartilage extracellular matrix

D. Rimoin, P. Roughley, B. Olsen, 1994, Human Genetics.

Human annulus progenitor cells: Analyses of this viable endogenous cell population

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2016, Journal of Orthopaedic Research.

Transplantation of Vascularized Composite Mandibular Allografts in Young Cynomolgus Monkeys

J. Stein, H. Gruber, Brian S. Kim, 1991, Annals of plastic surgery.

Biological Effects of Phosphate on Fibroblast-Like Synoviocytes

Yubo Sun, H. Gruber, E. Hanley, 2012 .

Ultrastructure of the Golgi Apparatus and Contractile Vacuole in Chlamydomonas reinhardi

H. Gruber, B. Rosario, 1979 .

Variation in eyespot ultrastructure in Chlamydomonas reinhardi (ac-31).

H. Gruber, B. Rosario, 1974, Journal of cell science.

Ultrastructure of Bone Cells in Paget's Disease of Bone

J. Windle, H. Gruber, G. Roodman, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix

H. Gruber, J. Ingram, E. Hanley, 2008, Arthritis research & therapy.

Human adipose-derived mesenchymal stem cells: direction to a phenotype sharing similarities with the disc, gene expression profiling, and coculture with human annulus cells.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2010, Tissue engineering. Part A.

Adipose-Derived Stem Cells: Characterization and Current Application in Orthopaedic Tissue Repair

H. Gruber, E. Hanley, Hazel Tapp, 2009, Experimental biology and medicine.

Adipose-Derived Stem Cells: Characterization and Current Application in Orthopaedic Tissue Repair

H. Gruber, E. Hanley, Joshua C. Patt, 2009, Experimental biology and medicine.

Practical histological methods for use with cultured cells

H. Gruber, J. Ingram, N. Zinchenko, 2009, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Three-dimensional culture of human disc cells within agarose or a collagen sponge: assessment of proteoglycan production.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2006, Biomaterials.

The Sand Rat Model for Disc Degeneration: Radiologic Characterization of Age-Related Changes: Cross-sectional and Prospective Analyses

H. Gruber, E. Hanley, H. Norton, 2002, Spine.

Optimization of 5-(and-6)-Carboxyfluorescein Diacetate Succinimidyl Ester for Labeling Human Intervertebral Disc Cells in Vitro

H. Gruber, J. Ingram, E. Hanley, 2000, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Osteopenia induced by long-term, low- and high-level exposure of the adult rat to lead.

H. Gruber, H. Gonick, M. Meyer, 1997, Mineral and electrolyte metabolism.

Histological Examination of Collagen and Proteoglycan Changes in Osteoarthritic Menisci

Yubo Sun, H. Gruber, J. Ingram, 2012, The open rheumatology journal.

H. Gruber, D. Gazit, A. Kahn, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs.

H. Gruber, Gretchen L. Hoelscher, E. Hanley, 2010, The spine journal : official journal of the North American Spine Society.

Geleophysic dysplasia: a storage disorder affecting the skin, bone, liver, heart, and trachea.

R. Pagon, D. Rimoin, H. Gruber, 1990, The Journal of pediatrics.

Quantitative histology of cartilage vascular canals in the human rib. Findings in normal neonates and children and in achondrogenesis II-hypochondrogenesis.

D. Rimoin, H. Gruber, R. Lachman, 1990, Journal of anatomy.

Autophagy in the Degenerating Human Intervertebral Disc: In Vivo Molecular and Morphological Evidence, and Induction of Autophagy in Cultured Annulus Cells Exposed to Proinflammatory Cytokines—Implications for Disc Degeneration

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2015, Spine.

Ultrastructural alterations and retention of the C-propeptide of type II collagen in human chondrocytes exposed in vitro to brefeldin A.

H. Gruber, 1993, Bone.

Analysis of meniscal degeneration and meniscal gene expression

Yubo Sun, H. Gruber, E. Hanley, 2010 .

Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches

H. Gruber, P. Mukherjee, L. Roy, 2014, BMC Cancer.

Vertebral Endplate and Disc Changes in the Aging Sand Rat Lumbar Spine: Cross-sectional Analyses of a Large Male and Female Population

H. Gruber, E. Hanley, H. Norton, 2007, Spine.

Bone Mineral Density of Lumbar Vertebral End Plates in the Aging Male Sand Rat Spine

H. Gruber, E. Hanley, H. James Norton, 2003, Spine.

Aortic thrombosis during sigmoidoscopy in Behçet's syndrome.

H. Gruber, M. Weisman, 1983, Archives of internal medicine.

Morphologic features of spontaneous annular tears and disc degeneration in the aging sand rat (Psammomys obesus obesus)

H. Gruber, EN Hanley, En Hanley, 2017, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Expression and localization of estrogen receptor-β in annulus cells of the human intervertebral disc and the mitogenic effect of 17-β-estradiol in vitro

Timothy A. Miller, H. Gruber, J. Ingram, 2002, BMC musculoskeletal disorders.

Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches

H. Gruber, P. Mukherjee, L. Roy, 2014, BMC Cancer.

Expression of serglycin in human disc is increased in degenerated discs and up-regulated in vitro by exposure to IL-1ß or TNF-α

H. Gruber, En Hanley Jr, 2018, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Desbuquois syndrome: clinical, radiographic, and morphologic characterization.

D. Rimoin, H. Gruber, M. Shohat, 1994, American journal of medical genetics.

H. Lidov, H. Gruber, N. Zinchenko, 2010, Human molecular genetics.

Variations in aggrecan localization and gene expression patterns characterize increasing stages of human intervertebral disk degeneration.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2011, Experimental and molecular pathology.

Alterations in islet cell ultrastructure following streptozotocin-induced diabetes in the rat

J. W. Osborne, H. Schedl, H. Gruber, 1980, Acta diabetologia latina.

Prostaglandin E1 and misoprostol increase epidermal growth factor production in 3D-cultured human annulus cells.

H. Gruber, Gretchen L. Hoelscher, J. Ingram, 2009, The spine journal : official journal of the North American Spine Society.

X-ray-induced division delay in Chlamydomonas reinhardi.

H. Gruber, D. Nachtwey, 1976, Radiation Research.

Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signaling

H. Gruber, P. Mukherjee, A. Kidiyoor, 2013, Breast Cancer Research.

Human intervertebral disc cells

H. Gruber, J. Ingram, E. Hanley, 2002 .

Spontaneous Age-related Cervical Disc Degeneration in the Sand Rat

H. Gruber, J. Ingram, E. Hanley, 2014, Clinical orthopaedics and related research.

Analysis of cell death and vertebral end plate bone mineral density in the annulus of the aging sand rat.

H. Gruber, J. Ingram, N. Zinchenko, 2008, The spine journal : official journal of the North American Spine Society.

Observations on morphologic changes in the aging and degenerating human disc: Secondary collagen alterations

H. Gruber, E. Hanley, 2002, BMC musculoskeletal disorders.

Cellular ingrowth and thickness changes in poly-L-lactide and polyglycolide matrices implanted subcutaneously in the rat.

K. Burg, D. Mooney, H. Gruber, 1998, Journal of biomedical materials research.

Alkaptonuria-Associated Changes in Disc Degeneration: A Case Report

H. Gruber, E. Hanley, 2015, JBJS case connector.

Superoxide dismutase activity of normal murine liver, regenerating liver, and H6 hepatoma.

L. Oberley, H. Gruber, S. Sahu, 1978, Journal of the National Cancer Institute.

Ultrastructure of the Human Intervertebral Disc During Aging and Degeneration: Comparison of Surgical and Control Specimens

H. Gruber, E. Hanley, 2002, Spine.

Cell shape and gene expression in human intervertebral disc cells: in vitro tissue engineering studies.

H. Gruber, J. Ingram, E. Hanley, 2003, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Surgical Management of Juvenile Amputation Overgrowth With a Synthetic Cap

J. Davids, H. Gruber, D. Blackhurst, 2004, Journal of pediatric orthopedics.

An improved staining method for intervertebral disc tissue

H. Gruber, J. Ingram, E. Hanley, 2002, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer

H. Gruber, P. Mukherjee, L. Roy, 2011, BMC Cancer.

Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc

P. Bornstein, E. Sage, H. Gruber, 2008, Arthritis research & therapy.

Increased Vascularization and Heterogeneity of Vascular Structures Occurring in Polyglycolide Matrices Containing Aortic Endothelial Cells Implanted in the Rat

David J. Mooney, Karen J. L. Burg, K. Burg, 1997 .

Subchondral Bone Resorption in Temporomandibular Joint Disorders

H. Gruber, J. Gregg, 2003, Cells Tissues Organs.

Structural correlation between collagen VI microfibrils and collagen VI banded aggregates.

Peter M. G. Munro, J. Squire, C. Baldock, 2006, Journal of structural biology.

Preoperative leuprolide acetate combined with Interceed* optimally reduces uterine adhesions and fibrosis in a rabbit model.

H. Gruber, B. Hurst, P. Marshburn, 2004, Fertility and sterility.

Cortistatin is endogenous to the human intervertebral disc and exerts in vitro mitogenic effects on annulus cells and a downregulatory effect on TNF-α expression.

H. Gruber, J. Ingram, E. Hanley, 2014, The spine journal : official journal of the North American Spine Society.

In vitro tetracycline labelling and bone cell survival in human trabecular bone explants.

H. Gruber, 1992, Bone.

Reprint of "Structural correlation between collagen VI microfibrils and collagen VI banded aggregates" [J. Struct. Biol. 154 (2006) 312-326].

Peter M. G. Munro, J. Squire, C. Baldock, 2006, Journal of Structural Biology.

A Novel Catechol-O-Methyltransferase Variant Associated with Human Disc Degeneration

C. Brouwer, N. Steuerwald, H. Gruber, 2014, International journal of medical sciences.

Effects of microgravity on bone healing in a rat fibular osteotomy model.

A Sarmiento, H E Gruber, A. Sarmiento, 1995, Clinical orthopaedics and related research.

Isolation and characterization of gap junctions in the osteoblastic MC3T3‐E1 cell line

H. Gruber, D. Yamaguchi, Austin Lee, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Inching our way up Mount Olympus: The evolving-systems approach to creative thinking.

H. Gruber, S. Davis, 1988 .

Adequate Dietary Calcium Mitigates Osteopenia Induced by Chronic Lead Exposure in Adult Rats

M. Pandian, N. Vaziri, H. Gruber, 1999, Mineral and Electrolyte Metabolism.

Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs

H. Gruber, J. Ingram, N. Zinchenko, 2009, Arthritis research & therapy.

Alteration in osteoblast cell number and cell activity in the presence of invading malignant fibrous histiocytoma

C. P. Schwinn, S. Massry, H. Gruber, 1987, Cancer.

New epiphyseal stippling syndrome with osteoclastic hyperplasia.

D. Rimoin, H. Gruber, M. Shohat, 1993, American journal of medical genetics.

High-mobility group box-1 gene, a potent proinflammatory mediators, is upregulated in more degenerated human discs in vivo and its receptor upregulated by TNF-α exposure in vitro.

H. Gruber, J. Ingram, E. Hanley, 2015, Experimental and molecular pathology.