A. Chiki

发表

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

H. Lashuel, A. Reif, A. Chiki, 2018, Journal of visualized experiments : JoVE.

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

H. Lashuel, F. Sobott, A. De Simone, 2020, Nature Communications.

The making of a Lewy body: the role of α-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions

G. Knott, C. Strand, M. Citron, 2018, bioRxiv.

Exploring the role of post‐translational modifications in regulating α‐synuclein interactions by studying the effects of phosphorylation on nanobody binding

C. Dobson, A. Mittermaier, M. Vendruscolo, 2018, Protein science : a publication of the Protein Society.

N-terminal phosphorylation of Huntingtin: A molecular switch for regulating Htt aggregation, helical conformation, internalization and nuclear targeting

H. Lashuel, A. Chiki, Mohamed Fares, 2018, bioRxiv.

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

A. Pastore, H. Lashuel, A. Chiki, 2017, Angewandte Chemie.

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.

H. Lashuel, A. Chiki, Ritwik Burai, 2015, Journal of the American Chemical Society.

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

C. Ross, J. Auwerx, M. Dragunow, 2020, The EMBO journal.

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

N. Guex, H. Lashuel, C. Iseli, 2022, npj Parkinson's Disease.

Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

H. Lashuel, M. dal Peraro, A. Chiki, 2021, bioRxiv.

Site-specific phosphorylation of Huntingtin exon 1 recombinant proteins enabled by the discovery of novel kinases

H. Lashuel, A. Reif, A. Chiki, 2020, bioRxiv.

A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research

H. Lashuel, A. Chiki, Senthil T. Kumar, 2019, bioRxiv.

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

H. Lashuel, A. Chiki, Mohamed Fares, 2018, The Journal of Biological Chemistry.

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

J. Marsh, A. Caricasole, H. Lashuel, 2017, Proceedings of the National Academy of Sciences.

Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils.

H. Lashuel, A. Chiki, Driss Boudeffa, 2022, Journal of the American Chemical Society.

The structural basis of huntingtin (Htt) fibril polymorphism, revealed by cryo-EM of exon 1 Htt fibrils

H. Lashuel, A. Chiki, Driss Boudeffa, 2021, bioRxiv.

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

H. Lashuel, D. Eliezer, A. Chiki, 2020, The Journal of Biological Chemistry.

Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM

F. Stellacci, A. Alexander-Katz, H. Lashuel, 2019, Proceedings of the National Academy of Sciences.

TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington’s disease

C. Ross, J. Auwerx, A. Caricasole, 2019, bioRxiv.

H. Lashuel, A. Chiki, Senthil T. Kumar, 2020, Journal of neurochemistry.

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

H. Lashuel, F. Sobott, A. De Simone, 2020, Nature Communications.

Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity

H. Lashuel, F. Sobott, A. Chiki, 2019, bioRxiv.

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

J. Wityak, H. Lashuel, C. Scheich, 2021, Scientific Reports.

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

H. Lashuel, A. Chiki, G. Dietler, 2016, Scientific Reports.

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1.

H. Lashuel, A. Chiki, G. Dietler, 2021, Journal of molecular biology.

Towards deciphering the Nt17 code: How the sequence and conformation of the first 17 amino acids in Huntingtin regulate the aggregation, cellular properties and neurotoxicity of mutant Httex1

H. Lashuel, A. Chiki, G. Dietler, 2021 .

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1

H. Lashuel, A. Chiki, G. Dietler, 2021, bioRxiv.

Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology

C. Sandi, H. Lashuel, A. Chiki, 2019, Neurobiology of Aging.

Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies

N. Guex, H. Lashuel, C. Iseli, 2022, bioRxiv.

Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo

D. D. Di Monte, H. Lashuel, A. Chiki, 2023, bioRxiv.

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

A. Pastore, H. Lashuel, A. Chiki, 2017, Angewandte Chemie.

Chronic corticosterone enhancement aggravates alpha-synuclein brain spreading pathology and substantia nigra neurodegeneration in mice

C. Sandi, H. Lashuel, A. Chiki, 2018, bioRxiv.