D. Riddell

发表

Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice

Liam Scott, T. Kiss, M. Hajós, 2012, Neurobiology of Aging.

Gene Correction of the Apolipoprotein (Apo) E2 Phenotype to Wild-type ApoE3 by in Situ Chimeraplasty*

J. S. Owen, I. Graham, D. Riddell, 2001, The Journal of Biological Chemistry.

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

D. Riddell, C. Dingwall, Christopher N. Johnson, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

ApoE Promotes the Proteolytic Degradation of Aβ

D. Holtzman, T. Willson, D. Holtzman, 2008, Neuron.

Animal Models of Alzheimer's Disease: Modeling Targets, Not Disease Accelerating Drug Discovery for Alzheimer's Disease: Best Practices for Preclinical Animal Studies

Kimberly Scearce-Levie, Patrick Sweeney, Dave Morgan, 2022 .

Tool Compounds Robustly Increase Turnover of an Artificial Substrate by Glucocerebrosidase in Human Brain Lysates

Claude Ambroise, D. Riddell, Z. Berger, 2015, PloS one.

Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux.

J. S. Owen, D. Riddell, J. V. Mulcahy, 2004, The Biochemical journal.

Discovery of a novel series of Notch-sparing gamma-secretase inhibitors.

B. Harrison, D. Huryn, J. Ellingboe, 2008, Bioorganic & medicinal chemistry letters.

Cerebrospinal Fluid β-Amyloid Turnover in the Mouse, Dog, Monkey and Human Evaluated by Systematic Quantitative Analyses

É. Hajós‐Korcsok, D. Riddell, H. Barton, 2012, Neurodegenerative Diseases.

Summary. A transgenic mouse bearing mutant transgenes linked to familial forms of Alzheimer’s disease (AD) for the amyloid precursor protein and presenilin-1 (TASTPM) showed Aß plaque deposition and age-related histological changes in associated brain

J. Richardson, P. Soden, S. Burbidge, 2007 .

A novel BACE inhibitor (PF-05297909): A two-part adaptive design to evaluate safety, pharmacokinetics and pharmacodynamics for modifying beta-amyloid in a first-in-human study

Kaori Ito, T. Nicholas, É. Hajós‐Korcsok, 2013, Alzheimer's & Dementia.

Porcine smooth muscle cell-conditioned medium stimulates LDL receptor activity in Hep G2 cells.

E. Gherardi, C. Moorby, D. Riddell, 1992, Journal of cell science.

Apolipoprotein E and regulation of cytokine-induced cell adhesion molecule expression in endothelial cells.

J. S. Owen, D. Riddell, A. Stannard, 1998, Atherosclerosis.

Inhibition of ADP-induced platelet aggregation by apoE is not mediated by membrane cholesterol depletion.

J. S. Owen, D. Riddell, J. Owen, 1995, Thrombosis research.

Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol.

R. C. Bush, D. Riddell, R. Williams, 1996, Biochemical pharmacology.

Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane.

J. S. Owen, A. Soutar, D. Riddell, 2001, Journal of lipid research.

Implementing CompacT SelecT Automated Cell Culture in Support of Alzheimer's Disease-Targeted Drug Discovery

D. Riddell, S. Nawoschik, J. Dunlop, 2008 .

Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.

J. Richardson, P. Soden, S. Burbidge, 2008, Histology and histopathology.

RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability.

R. C. Bush, D. Riddell, R. Williams, 1996, Biochemical pharmacology.

JPET #152975 1 TITLE: GSI-953 (begacestat): A novel, selective thiophene sulfonamide inhibitor of APP γ-secretase for the treatment of Alzheimer’s disease

T. Comery, B. Harrison, M. Pangalos, 2009 .

Summary Porcine smooth muscle cell-conditioned medium stimulates LDL receptor activity in Hep G 2 cells

E. Gherardi, C. Moorby, D. Riddell, 2022 .

Apolipoprotein E Inhibits Platelet Aggregation through the L-Arginine:Nitric Oxide Pathway

D. Riddell, A. Graham, J. Owen, 1997, The Journal of Biological Chemistry.

Hypolipidemic 2-[4-(1,1-dimethylethyl)phenyl]-4H-3,1-benzoxazin-4-ones. Structure-activity relationships of a novel series of high-density lipoprotein elevators.

C. G. Newton, D. Riddell, B. Wyman, 1989, Journal of medicinal chemistry.

Intramuscular injection of a plasmid vector expressing human apolipoprotein E limits progression of xanthoma and aortic atheroma in apoE-deficient mice.

D. Riddell, A. Tagalakis, M. Dunckley, 2000, Human molecular genetics.

Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.

Gregory W. Kauffman, Chakrapani Subramanyam, L. Pustilnik, 2012, Journal of medicinal chemistry.

A comparison of the pharmacological and biochemical properties of substrate‐selective monoamine oxidase inhibitors

D. Riddell, D. Maxwell, C. J. Coulson, 1972, British journal of pharmacology.

Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.

M. Ashton, D. Riddell, R. Williams, 1996, Journal of medicinal chemistry.

Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer's Disease

T. Comery, B. Harrison, M. Pangalos, 2009, Journal of Pharmacology and Experimental Therapeutics.

Nitric oxide and platelet aggregation.

D. Riddell, J. Owen, James S. Owen, 1999, Vitamins and hormones.

Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice

K. Atchison, D. Riddell, C. Gonzales, 2014, Pharmacology Biochemistry and Behavior.

Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Graham M. West, Sherry L. Niessen, Claude Ambroise, 2016, Nature Communications.

Characterization of the Ectodomain Shedding of the β-Site Amyloid Precursor Protein-cleaving Enzyme 1 (BACE1)*

D. Riddell, C. Dingwall, A. Faller, 2003, Journal of Biological Chemistry.

The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

T. Comery, M. Pangalos, D. Riddell, 2007, Molecular and Cellular Neuroscience.

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

M. Pangalos, K. Atchison, D. Riddell, 2008, The Journal of Neuroscience.

Heterocyclic analogues of chlorcyclizine with potent hypolipidemic activity.

J. Salmon, M. Ashton, D. Riddell, 1984, Journal of medicinal chemistry.

Systemic immune‐checkpoint blockade with anti‐PD1 antibodies does not alter cerebral amyloid‐β burden in several amyloid transgenic mouse models

Nicolas Moindrot, G. Nabel, Yaming Wang, 2018, Glia.

Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

T. Comery, A. Robichaud, M. Pangalos, 2008, Proceedings of the National Academy of Sciences.

Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical Analyses

É. Hajós‐Korcsok, K. Bales, D. Riddell, 2012, Journal of Pharmacology and Experimental Therapeutics.

Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

D. Riddell, C. Dingwall, I. Hussain, 2001, Current Biology.

Cell-derived Apolipoprotein E (ApoE) Particles Inhibit Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression in Human Endothelial Cells*

A. von Eckardstein, P. Cullen, G. Dickson, 2001, The Journal of Biological Chemistry.

MEASUREMENT OF ENDOGENOUS MOUSE TAU IN CEREBROSPINAL FLUID FROM AGED PDAPP MICE FOLLOWING TREATMENT WITH AB-LOWERING COMPOUNDS

D. McKinzie, R. Demattos, D. Riddell, 2018, Alzheimer's & Dementia.

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.

Claude Ambroise, D. Karanian, K. Bales, 2018, Journal of medicinal chemistry.

rapid communication Identification and characterization of LRP8 (apoER2) in human blood platelets

D. Riddell, D. V. Vinogradov, N. Chadwick, 2022 .

Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.

K. Parris, K. Atchison, D. Riddell, 2015, Journal of medicinal chemistry.

Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.

T. Comery, K. Fan, B. Harrison, 2008, Journal of medicinal chemistry.

Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation

T. Kiss, M. Hajós, É. Hajós‐Korcsok, 2013, Front. Pharmacol..

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

J. Pandit, K. Parris, Eric F. Johnson, 2015, Journal of medicinal chemistry.

Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons

P. Maycox, R. Prinjha, S. Burbidge, 2003, Molecular and Cellular Neuroscience.

RP 73163: A bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor

R. C. Bush, M. Ashton, D. Riddell, 1996 .

RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT)

R. C. Bush, M. Ashton, D. Lythgoe, 1992 .

Quantitative Pharmacokinetic/Pharmacodynamic Analyses Suggest That the 129/SVE Mouse Is a Suitable Preclinical Pharmacology Model for Identifying Small-Molecule γ-Secretase Inhibitors

L. Pustilnik, A. Stepan, K. Atchison, 2011, Journal of Pharmacology and Experimental Therapeutics.

Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability.

M. Malamas, J. Erdei, K. Fan, 2010, Bioorganic & medicinal chemistry letters.

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality

K. Parris, Eric F. Johnson, K. Atchison, 2016, Journal of medicinal chemistry.

Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.

B. Harrison, D. Huryn, K. Atchison, 2009, Bioorganic & medicinal chemistry.

(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.

T. Comery, B. Harrison, Z. Wang, 2009, Bioorganic & medicinal chemistry letters.

Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.

L. Pustilnik, A. Stepan, R. Obach, 2011, Journal of medicinal chemistry.

Utilizing CYP2D6 and BACE1 Structure Complexes to Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

K. Parris, Eric F. Johnson, S. Sakya, 2015 .

Blood platelets do not contain the low-density receptor-related protein (LRP).

D. Riddell, J. Gliemann, D. V. Vinogradov, 1998, Biochemical Society transactions.