P. Tyrrell

N. Rothwell, L. Aarons, P. Hutchinson, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Impact and sustainability of centralising acute stroke services in English metropolitan areas: retrospective analysis of hospital episode statistics and stroke national audit data

C. McKevitt, C. Wolfe, S. Turner, 2019, British Medical Journal.

Predicting Aspiration After Hemispheric Stroke from Timing Measures of Oropharyngeal Bolus Flow and Laryngeal Closure

J. Y. Goulermas, M. Power, S. Hamdy, 2009, Dysphagia.

Can a Novel Clinical Risk Score Improve Pneumonia Prediction in Acute Stroke Care? A UK Multicenter Cohort Study

P. Heuschmann, C. Wolfe, P. Tyrrell, 2015, Journal of the American Heart Association.

Inflammation and ischaemic stroke

E. Warburton, N. Sattar, K. Muir, 2007, Current opinion in neurology.

Variability of the systemic acute phase response after ischemic stroke

N. Rothwell, P. Tyrrell, R. Georgiou, 2006, Journal of the Neurological Sciences.

Development and feasibility testing of an oral hygiene intervention for stroke unit care

S. Hamdy, P. Tyrrell, S. Hulme, 2017, Gerodontology.

Lessons for major system change: centralization of stroke services in two metropolitan areas of England

C. McKevitt, C. Wolfe, S. Turner, 2016, Journal of health services research & policy.

Does Inflammation Predispose to Recurrent Vascular Events after Recent Transient Ischaemic Attack and Minor Stroke? the North West of England Transient Ischaemic Attack and Minor Stroke (NORTHSTAR) Study

N. Rothwell, J. Staniland, A. Payton, 2011, International journal of stroke : official journal of the International Stroke Society.

Fatigue after stroke

P. Tyrrell, D. Smithard, 2005 .

Which factors in fl uence decisions to transfer and treat patients with acute intracerebral haemorrhage and which are associated with prognosis ? A retrospective cohort study

H. Patel, A. Parry-Jones, P. Tyrrell, 2013 .

Impact of specialist neurovascular care in subarachnoid haemorrhage

H. Patel, P. Tyrrell, A. Vail, 2015, Clinical Neurology and Neurosurgery.

A survey of the practice of stroke doctors in developing transient ischaemic attack services in the UK.

P. Tyrrell, J. Greenhalgh, P. Beech, 2007, Journal of evaluation in clinical practice.

Improving care for people after stroke: how change was actively facilitated.

P. Tyrrell, K. Rothwell, D. Bamford, 2013, Journal of health organization and management.

Achieving Knowledge Transfer in Healthcare: A Strategy for Success?

P. Tyrrell, K. Rothwell, D. Bamford, 2010 .

Did a quality improvement collaborative make stroke care better? A cluster randomized trial

M. Dixon-Woods, M. Power, G. Parry, 2014, Implementation Science.

Recruiting to inpatient-based rehabilitation trials: lessons learned

P. Tyrrell, A. Vail, S. Tyson, 2015, Trials.

Clinical and positron emission tomographic studies in the 'extrapyramidal syndrome' of dementia of the Alzheimer type.

Richard S. J. Frackowiak, R. Frackowiak, M. Rossor, 1990, Archives of neurology.

Apraxia of gait or higher level gait disorders: review and description of two cases of progressive gait disturbance due to frontal lobe degeneration.

P. Tyrrell, 1994, Journal of the Royal Society of Medicine.

Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group

Á. Chamorro, P. Langhorne, J. Montaner, 2015, Stroke.

Interleukin-1 in Stroke: From Bench to Bedside.

N. Rothwell, A. Parry-Jones, S. Allan, 2016, Stroke.

Diagnosis and initial management of transient ischaemic attack.

P. Tyrrell, A. Rudd, S. Swain, 2010, Clinical medicine.

Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression.

N. Rothwell, P. Tyrrell, A. Vail, 2012, Cytokine.

Post stroke shoulder pain: more common than previously realized

A. K. Jones, D. Bowsher, P. Tyrrell, 2000, European journal of pain.

Shoulder pain after stroke: case report and review

A. K. Jones, P. Tyrrell, G. E. Gamble, 1999, Annals of the rheumatic diseases.

The importance of angiographic and venographic cranial imaging in intracerebral hemorrhage occurring during pregnancy and the puerperium

H. Patel, P. Tyrrell, M. Kirkman, 2011, European journal of neurology.

Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multi-centre randomised controlled trial.

P. Tyrrell, 2005 .

EXTRAPYRAMIDAL SIGNS IN DEMENTIA OF ALZHEIMER TYPE

M. Rossor, P. Tyrrell, 1989, The Lancet.

Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection

N. Rothwell, H. Patel, P. Tyrrell, 2012, Journal of Neuroinflammation.

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2 Trial

N. Rothwell, A. Parry-Jones, S. Allan, 2018, Stroke.

Measuring stroke care and quality in routine data sets.

P. Tyrrell, A. Rudd, B. Bray, 2013, JAMA neurology.

Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage

N. Rothwell, P. Tyrrell, A. Vail, 2012, Journal of NeuroInterventional Surgery.

Study design and population pharmacokinetic analysis of a phase II dose-ranging study of interleukin-1 receptor antagonist

N. Rothwell, P. Tyrrell, S. Hulme, 2016, Journal of Pharmacokinetics and Pharmacodynamics.

Reference tissue kinetics extraction from [11C]-(R)-PK11195 scans on the high resolution research tomograph (HRRT)

R. Boellaard, M. Jones, R. Hinz, 2008, NeuroImage.

Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke

Stavros Stivaros, Alan Jackson, Nancy Rothwell, 2009, European Radiology.

Authors’ reply to Hill and Rudd

C. McKevitt, C. Wolfe, S. Turner, 2014, BMJ : British Medical Journal.

MATTERS ARISING

P. Tyrrell, M. Rosser, Pippa J. Tyrrell, 1992 .

Oxygen metabolism in the dementias

R. Frackowiak, P. Tyrrell, R. Dolan, 1989 .

An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis

N. Rothwell, J. Hallenbeck, P. Tyrrell, 2003, Journal of Neuroimmunology.

Clinical effectiveness, cost-effectiveness and service users' perceptions of early, well-resourced communication therapy following a stroke: a randomised controlled trial (the ACT NoW Study).

M. L. Lambon Ralph, C. Watkins, A. Bowen, 2012, Health technology assessment.

Interleukin-1 and neuronal injury

N. Rothwell, S. Allan, P. Tyrrell, 2005, Nature Reviews Immunology.

Interleukin-1 Receptor Antagonist Penetrates Human Brain at Experimentally Therapeutic Concentrations

N. Rothwell, M. Rowland, P. Tyrrell, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Inflammation in Acute Ischemic Stroke and its Relevance to Stroke Critical Care

Hedley C. A. Emsley, Pippa J. Tyrrell, P. Tyrrell, 2008, Neurocritical care.

Organisation, practice and experiences of mouth hygiene in stroke unit care: a mixed-methods study.

P. Tyrrell, M. Horne, A. Walls, 2015, Journal of clinical nursing.

Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2)

N. Ward, A. Majid, D. Bulters, 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

Inflammation and Infection in Clinical Stroke

P. Tyrrell, H. Emsley, 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Sciatic nerve damage due to toilet seat entrapment: another Saturday night palsy.

M. Rossor, P. Tyrrell, M. Feher, 1989, Journal of neurology, neurosurgery, and psychiatry.

Detection of Atrial Fibrillation After Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis

Kennedy R. Lees, Andy Vail, A. Majid, 2014, Stroke.

Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

N. Rothwell, G. D. del Zoppo, J. Hallenbeck, 2004, BMC neurology.

Diagnosis and initial management of acute stroke and transient ischaemic attack: summary of NICE guidance

Anthony Rudd, P. Tyrrell, A. Rudd, 2008, BMJ : British Medical Journal.

Heterogeneity in progressive aphasia due to focal cortical atrophy. A clinical and PET study.

M N Rossor, E. Warrington, R. Frackowiak, 1990, Brain : a journal of neurology.

Recent advances in the understanding of dementia.

M. Rossor, P. Tyrrell, 1988, Postgraduate medical journal.

Difficulties with recruiting into neurosurgical clinical trials: The Surgical Trial in IntraCerebral Haemorrhage II as an example

H. Patel, P. Tyrrell, M. Kirkman, 2011, British journal of neurosurgery.

Phase II anti-inflammatory and immune-modulating drugs for acute ischaemic stroke

P. Tyrrell, Á. Dénes, M. Di Napoli, 2015, Expert opinion on investigational drugs.

A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

N. Rothwell, P. Tyrrell, R. Georgiou, 2005, Journal of Neurology, Neurosurgery & Psychiatry.

Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage.

N. Rothwell, M. Rowland, P. Tyrrell, 2008, British journal of clinical pharmacology.

In England

C. McKevitt, C. Wolfe, S. Turner, 2007, Words as Grain.

Explaining outcomes in major system change: a qualitative study of implementing centralised acute stroke services in two large metropolitan regions in England

C. McKevitt, C. Wolfe, S. Turner, 2015, Implementation Science.

What is rehabilitation potential? Development of a theoretical model through the accounts of healthcare professionals working in stroke rehabilitation services

A. Bowen, P. Tyrrell, K. Woodward-Nutt, 2015, Disability and rehabilitation.

Progressive frontal gait disturbance with atypical Alzheimer’s disease and corticobasal degeneration

P. Thompson, C. Marsden, P. Lantos, 1999, Journal of neurology, neurosurgery, and psychiatry.

Feasibility of assessing the needs of stroke patients after six months using the GM-SAT

P. Tyrrell, K. Rothwell, D. Bamford, 2013, Clinical rehabilitation.

The association between delays in screening for and assessing dysphagia after acute stroke, and the risk of stroke-associated pneumonia

C. Wolfe, P. Enderby, P. Tyrrell, 2016, Journal of Neurology, Neurosurgery & Psychiatry.

The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial

N. Rothwell, P. Hutchinson, P. Tyrrell, 2014, Journal of Neuroinflammation.

Associations between the organisation of stroke services, process of care, and mortality in England: prospective cohort study

C. Wolfe, S. Ayis, P. Tyrrell, 2013, BMJ.

Prognosis in patients with transient ischaemic attack (TIA) and minor stroke attending TIA services in the North West of England: The NORTHSTAR Study

P. Tyrrell, J. Selvarajah, S. Hulme, 2007, Journal of Neurology, Neurosurgery, and Psychiatry.

Awareness of Dysphagia by Patients Following Stroke Predicts Swallowing Performance

M. Power, S. Hamdy, D. Thompson, 2003, Dysphagia.

Adjunctive functional pharyngeal electrical stimulation reverses swallowing disability after brain lesions.

J. Rothwell, S. Hamdy, D. Thompson, 2010, Gastroenterology.

The Nottingham Fatigue after Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression

G. Mead, N. Ward, N. Lincoln, 2017, Clinical rehabilitation.

Short-term effects of ambient particulates and gaseous pollutants on the incidence of transient ischaemic attack and minor stroke: a case-crossover study

R. Agius, P. Tyrrell, Craig J. Smith, 2012, Environmental Health.

Weekly variation in health-care quality by day and time of admission: a nationwide, registry-based, prospective cohort study of acute stroke care

C. Wolfe, H. Hemingway, P. Tyrrell, 2016, The Lancet.

Associations between Stroke Mortality and Weekend Working by Stroke Specialist Physicians and Registered Nurses: Prospective Multicentre Cohort Study

C. Wolfe, S. Ayis, P. Tyrrell, 2014, PLoS medicine.

Stroke thrombolysis in England: an age stratified analysis of practice and outcome.

C. Wolfe, P. Tyrrell, A. Rudd, 2013, Age and ageing.

Why do stroke survivors not receive recommended amounts of active therapy? Findings from the ReAcT study, a mixed-methods case-study evaluation in eight stroke units

A. Forster, L. Brkic, H. Rodgers, 2018, Clinical rehabilitation.

Innovations in major system reconfiguration in England: a study of the effectiveness, acceptability and processes of implementation of two models of stroke care

C. McKevitt, R. Hunter, R. Boaden, 2013, Implementation Science.

The unreliability of clinical measures of muscle tone: implications for stroke therapy.

E. Faragher, R. Tallis, P. Tyrrell, 2000, Age and ageing.

The association of gegenhalten in the upper limbs with dyspraxia.

M. Rossor, P. Tyrrell, 1988, Journal of neurology, neurosurgery, and psychiatry.

Effects of Centralizing Acute Stroke Services on Stroke Care Provision in Two Large Metropolitan Areas in England

C. McKevitt, C. Wolfe, S. Turner, 2015, Stroke.

The Oxfordshire Community Stroke Project classification in the early hours of ischemic stroke and relation to infarct site and size on cranial computed tomography.

P. Tyrrell, D. Hughes, A. Vail, 2001, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Alteplase for Acute Ischemic Stroke: Outcomes by Clinically Important Subgroups in the Third International Stroke Trial

Joanna M. Wardlaw, Eleni Sakka, Geoff Cohen, 2015, Stroke.

Long-term temperature-related morbidity after brain damage: Survivor-reported experiences

P. Tyrrell, C. Childs, A. Jones, 2008, Brain injury.

The study protocol of: ‘Initiating end of life care in stroke: clinical decision-making around prognosis’

Lupetu Ives Ntambwe, T. Bucknall, S. Payne, 2014, BMC Palliative Care.

Evaluating Oral Stimulation as a Treatment for Dysphagia after Stroke

C. Fraser, M. Power, S. Hamdy, 2006, Dysphagia.

In fl ammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage

N. Rothwell, P. Tyrrell, A. Vail, 2013 .

In ﬂ ammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage

P. Tyrrell, S. Hopkins, C. McMahon, 2012 .

Stroke thrombolysis: where are we and where are we going?

P. Tyrrell, R. Hurford, Pippa J. Tyrrell, 2013, Clinical medicine.

Bespoke versus off-the-shelf ankle-foot orthosis for people with stroke: randomized controlled trial

P. Tyrrell, K. Woodward-Nutt, A. Vail, 2018, Clinical rehabilitation.

Evaluation of a service development to implement the top three process indicators for quality stroke care.

M. Power, S. Cross, P. Tyrrell, 2007, Journal of evaluation in clinical practice.

Heterogeneity in progressive aphasia due to focal cortical atrophy. A clinical and PET study

Pippa J. Tyrrell, P. Tyrrell, 1995 .

Peripheral inflammatory markers in amnestic mild cognitive impairment

A. Burns, Julie Morris, P. Tyrrell, 2013, International journal of geriatric psychiatry.

Regulation of interleukin-1 in acute brain injury.

D. Brough, S. Allan, P. Tyrrell, 2011, Trends in pharmacological sciences.

The potential role of cost-utility analysis in the decision to implement major system change in acute stroke services in metropolitan areas in England

C. McKevitt, C. Wolfe, S. Turner, 2018, Health Research Policy and Systems.

Characterizing the Mechanisms of Central and Peripheral Forms of Neurostimulation in Chronic Dysphagic Stroke Patients

S. Hamdy, E. Michou, P. Tyrrell, 2014, Brain Stimulation.

SUBCUTANEOUS INTERLEUKIN-1 RECEPTOR ANTAGONIST IN ISCHEMIC STROKE (SCIL-STROKE): A RANDOMIZED CONTROLLED PHASE 2 TRIAL

N. Rothwell, A. Parry-Jones, S. Allan, 2018 .

Dementia with Lewy bodies studied with positron emission tomography.

P. Lantos, M. Rossor, R. Cordery, 2001, Archives of neurology.

Classification of Minor Stroke: Intra- and Inter-Observer Reliability

P. Tyrrell, J. Selvarajah, A. Vail, 2009, Cerebrovascular Diseases.

Imaging in young adults with intracerebral hemorrhage

H. Patel, P. Tyrrell, M. Kirkman, 2012, Clinical Neurology and Neurosurgery.

Accuracy and Clinical Usefulness of Intracerebral Hemorrhage Grading Scores: A Direct Comparison in a UK Population

H. Patel, A. Parry-Jones, P. Tyrrell, 2013, Stroke.

Psychiatric symptoms in patients with focal cortical degeneration.

M. Rossor, P. Tyrrell, R. Lawrence, 1994, Behavioural neurology.

Progressive Aphasia and Other Focal Syndromes

M. Rossor, P. Tyrrell, 1994 .

Oxygen metabolism in the degenerative dementias

R. Frackowiak, M. Rossor, P. Tyrrell, 1990 .

Poststroke shoulder pain: a prospective study of the association and risk factors in 152 patients from a consecutive cohort of 205 patients presenting with stroke

D. Bowsher, P. Tyrrell, H. Laasch, 2002, European journal of pain.

Bigger, Faster?: Associations Between Hospital Thrombolysis Volume and Speed of Thrombolysis Administration in Acute Ischemic Stroke

C. Wolfe, P. Tyrrell, A. Rudd, 2013, Stroke.

The Nottingham Fatigue After Stroke (NotFAST) study: results from follow-up six months after stroke

N. Ward, N. Lincoln, L. Hawkins, 2017, Topics in stroke rehabilitation.

Which factors influence decisions to transfer and treat patients with acute intracerebral haemorrhage and which are associated with prognosis? A retrospective cohort study

H. Patel, A. Parry-Jones, P. Tyrrell, 2013, BMJ Open.

Derivation and External Validation of a Case Mix Model for the Standardized Reporting of 30-Day Stroke Mortality Rates

C. Wolfe, P. Tyrrell, A. Rudd, 2014, Stroke.

Acute Ischemic Stroke Bigger , Faster ? : Associations Between Hospital Thrombolysis

P. Tyrrell, A. Rudd, G. Cloud, 2013 .

Care-limiting decisions in acute stroke and association with survival: analyses of UK national quality register data

A. Parry-Jones, P. Tyrrell, A. Rudd, 2016, International journal of stroke : official journal of the International Stroke Society.

Phase II Pragmatic Randomized Controlled Trial of Patient-Led Therapies (Mirror Therapy and Lower-Limb Exercises) During Inpatient Stroke Rehabilitation

R. Selles, P. Tyrrell, J. Wilkinson, 2015, Neurorehabilitation and neural repair.

Patient-directed therapy during in-patient stroke rehabilitation: stroke survivors’ views of feasibility and acceptability

P. Tyrrell, A. Vail, M. Horne, 2015, Disability and rehabilitation.

Explorer The Nottingham Fatigue after Stroke ( NotFAST ) study

G. Mead, N. Ward, N. Lincoln, 2017 .

The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease.

T Jones, C D Marsden, D J Brooks, 1990, Archives of neurology.

Clinical effectiveness, cost-effectiveness and service users' perceptions of early, well-resourced communication therapy following a stroke: a randomised controlled trial (the ACT NoW Study).

C. Watkins, A. Bowen, P. Tyrrell, 2012 .

Patterns of Cerebral Metabolism in Degenerative Dementia

R. Frackowiak, M. Rossor, P. Tyrrell, 1990 .

Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients.

N. Rothwell, P. Tyrrell, R. Georgiou, 2005, Stroke.

Phase II anti-inflammatory and immune-modulating drugs for acute ischaemic stroke

P. Tyrrell, Á. Dénes, M. Di Napoli, 2015, Expert opinion on investigational drugs.

Brain inflammation is induced by co-morbidities and risk factors for stroke

K. Herholz, B. McColl, N. Rothwell, 2011, Brain, Behavior, and Immunity.

Fatigue after stroke

S. Phillips, G. Eskes, J. Ingles, 2005 .

What is rehabilitation potential? Development of a theoretical model through the accounts of healthcare professionals working in stroke rehabilitation services

A. Bowen, P. Tyrrell, K. Woodward-Nutt, 2015, Disability and rehabilitation.

Effectiveness of enhanced communication therapy in the first four months after stroke for aphasia and dysarthria: a randomised controlled trial

C. Watkins, M. L. Ralph, A. Bowen, 2012, BMJ : British Medical Journal.

Interleukin-1 in Stroke: From Bench to Bedside.

N. Rothwell, A. Parry-Jones, S. Allan, 2016, Stroke.

Classification of Minor Stroke: Intra- and Inter-Observer Reliability

P. Tyrrell, J. Selvarajah, A. Vail, 2009, Cerebrovascular Diseases.

Associations between the organisation of stroke services, process of care, and mortality in England: prospective cohort study

Dylan S. Small, D. Small, C. Wolfe, 2013, BMJ.

Clinical risk scores for predicting stroke-associated pneumonia: A systematic review

Á. Chamorro, P. Langhorne, J. Montaner, 2016, European stroke journal.

Study design and population pharmacokinetic analysis of a phase II dose-ranging study of interleukin-1 receptor antagonist

N. Rothwell, P. Tyrrell, S. Hulme, 2016, Journal of Pharmacokinetics and Pharmacodynamics.

Why do patients with stroke not receive the recommended amount of active therapy (ReAcT)? Study protocol for a multisite case study investigation

A. Forster, L. Brkic, H. Rodgers, 2015, BMJ Open.

The role of cortisol in immunosuppression in subarachnoid haemorrhage

N. Rothwell, P. Tyrrell, S. Hulme, 2023, European Journal of Medical Research.

Detection of Atrial Fibrillation After Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis

A. Majid, J. Dawson, K. Lees, 2014, Stroke.

Post-Stroke Pain

P. Tyrrell, A. Jones, 2015 .