J. Pugin

T. Perneger, J. Pugin, J. Romand, 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Oral Decontamination and Ventilator-Associated Pneumonia-Reply

P. Suter, J. Pugin, 1991 .

Oropharyngeal Decontamination Decreases Incidence of Ventilator-Associated Pneumonia: A Randomized, Placebo-Controlled, Double-blind Clinical Trial

R. Auckenthaler, P. Suter, J. Pugin, 1991 .

COVID‐19 encephalopathy: Clinical and neurobiological features

G. Allali, F. Herrmann, F. Assal, 2021, Journal of medical virology.

How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome

J. Pugin, 2012, Annals of Intensive Care.

Dear SIRS, the concept of “alarmins” makes a lot of sense!

J. Pugin, 2008, Intensive Care Medicine.

The role of MD-2 in the opsonophagocytosis of Gram-negative bacteria

J. Pugin, P. Tissières, 2009, Current opinion in infectious diseases.

Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality

A. McMahon, S. de Seigneux, J. Pugin, 2020, Nature metabolism.

Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis

M. Antonelli, S. Nava, P. Metnitz, 2004, Intensive Care Medicine.

Therapeutic anticoagulation to prevent thrombosis, coagulopathy, and mortality in severe COVID‐19: The Swiss COVID‐HEP randomized clinical trial

L. Mazzolai, C. Combescure, A. Calmy, 2022, Research and Practice in Thrombosis and Haemostasis.

Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China

J. Rello, J. Pugin, K. Arvaniti, 2020, Anaesthesia Critical Care & Pain Medicine.

Role of biomarkers in the management of antibiotic therapy: an expert panel review: I – currently available biomarkers for clinical use in acute infections

N. Roche, C. Brun-Buisson, J. Pugin, 2013, Annals of Intensive Care.

A critical role for monocytes and CD14 in endotoxin-induced endothelial cell activation

R. Ulevitch, J. Pugin, P. Tobias, 1993, The Journal of experimental medicine.

Year in review in intensive care medicine. 2005. I. Acute respiratory failure and acute lung injury, ventilation, hemodynamics, education, renal failure

M. Antonelli, S. Nava, P. Metnitz, 2006, Intensive Care Medicine.

Cyclic stretch of human lung cells induces an acidification and promotes bacterial growth.

J. Pugin, P. Charles, P. Tissières, 2008, American journal of respiratory cell and molecular biology.

Rapid diagnosis of gram negative pneumonia by assay of endotoxin in bronchoalveolar lavage fluid.

R. Auckenthaler, P. Suter, J. Pugin, 1992, Thorax.

Performance of the Cepheid Methicillin-Resistant Staphylococcus aureus/S. aureus Skin and Soft Tissue Infection PCR Assay on Respiratory Samples from Mechanically Ventilated Patients for S. aureus Screening during the Phase 2 Double-Blind SAATELLITE Study

H. Goossens, H. Jafri, J. Pugin, 2022, Journal of clinical microbiology.

Interstitial, Inflammatory and Occupational Lung Disease: Ventilator‐Induced Lung Injury An Inflammatory Disease?

J. Pugin, P. Jolliet, 1998 .

The search for diagnostic markers in sepsis: many miles yet to go.

J. Pugin, C. Calfee, 2012, American journal of respiratory and critical care medicine.

An interventional quasi-experimental study to evaluate the impact of a rapid screening strategy in improving control of nosocomial extended-spectrum beta-lactamase-producing Enterobacterales and carbapenemase-producing organisms in critically ill patients

P. François, J. Schrenzel, J. Pugin, 2022, Critical Care.

A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2

P. O’Toole, L. O’Mahony, J. Pugin, 2022, Gut microbes.

Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro.

X. Ding, J. Pugin, P. Tobias, 1994, The Journal of clinical investigation.

Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea

A. Mebazaa, M. Antonelli, P. Metnitz, 2009, Intensive Care Medicine.

Year in review in Intensive Care Medicine 2009. Part III: Mechanical ventilation, acute lung injury and respiratory distress syndrome, pediatrics, ethics, and miscellanea

A. Mebazaa, M. Antonelli, F. Lemaire, 2010, Intensive Care Medicine.

Membrane interaction of TNF is not sufficient to trigger increase in membrane conductance in mammalian cells

P. De Baetselier, F. G. van der Goot, L. Fransen, 1999, FEBS letters.

Is anti-tumor necrosis factor therapy associated with increased mortality in patients with severe sepsis caused by pneumonia?

D. Pittet, J. Pugin, S. Harbarth, 2004, The Journal of infectious diseases.

A first update on mapping the human genetic architecture of COVID-19

Eurie L. Hong, E. F. Perez, Rachel G Liao, 2022, Nature.

Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease

C. Cohen, S. de Seigneux, J. Pugin, 2022, Journal of the American Society of Nephrology : JASN.

Year in review in intensive care medicine, 2005. II. Infection and sepsis, ventilator-associated pneumonia, ethics, haematology and haemostasis, ICU organisation and scoring, brain injury

M. Antonelli, S. Nava, P. Metnitz, 2006, Intensive Care Medicine.

Recognition of Bacteria and Bacterial Products by Host Immune Cells in Sepsis

J. Pugin, 1996 .

b -Adrenergic agonists exert their “anti-inﬂammatory” effects in monocytic cells through the I k B/NF- k B pathway

J. Pugin, P. Farmer, 2000 .

beta-adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the IkappaB/NF-kappaB pathway.

J. Pugin, P. Farmer, 2000, American journal of physiology. Lung cellular and molecular physiology.

D. Pugin, J. Pugin, M. Vargas, 2020, Neurology.

Year in review in Intensive Care Medicine, 2007. I. Experimental studies. Clinical studies: brain injury and neurology, renal failure and endocrinology

A. Mebazaa, M. Antonelli, P. Metnitz, 2008, Intensive Care Medicine.

CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment.

H. Hammad, I. Tillie‐Leblond, B. Wallaert, 2000, American journal of respiratory and critical care medicine.

Activation of endothelial cells by endotoxin: direct versus indirect pathways and the role of CD14.

R. Ulevitch, J. Pugin, P. Tobias, 1995, Progress in clinical and biological research.

Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry

M. Giacomini, M. Antonelli, T. Welte, 2022, Critical Care.

Epoetin administrated after cardiac surgery: effects on renal function and inflammation in a randomized controlled study

S. de Seigneux, J. Pugin, B. Ponte, 2012, BMC Nephrology.

H. Goossens, H. Jafri, J. Pugin, 2022, Journal of clinical microbiology.

Mechanical Ventilation Alters the Development of Staphylococcus aureus Pneumonia in Rabbit

J. Pugin, P. Charles, R. Bruyère, 2016, PloS one.

Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide

J. Pugin, P. Charles, P. Tissières, 2011, Critical care.

SARS‐CoV‐2 infection as a trigger of humoral response against apolipoprotein A‐1

S. Yerly, I. Guessous, S. Stringhini, 2021, European journal of clinical investigation.

SARS-COV2- infection as a trigger of humoral response against apolipoprotein A-1

I. Guessous, S. Stringhini, J. Pugin, 2021, Atherosclerosis.

Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort

T. Welte, R. Ceriani, C. Cogliati, 2021, Critical Care.

Role of proinflammatory activity contained in gastric juice from intensive care unit patients to induce lung injury in a rabbit aspiration model

J. Pugin, L. Papazian, T. Martin, 2008, Critical care medicine.

The impact of mechanical ventilation on the moxifloxacin treatment of experimental pneumonia caused by Streptococcus pneumoniae

J. Pugin, P. Charles, L. Piroth, 2005, Critical care medicine.

Delayed intubation is associated with mortality in patients with severe COVID-19: A single-centre observational study in Switzerland

J. Pugin, H. Quintard, K. Bendjelid, 2022, Anaesthesia Critical Care & Pain Medicine.

Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsis

D. Pittet, J. Pugin, S. Harbarth, 2005, European Journal of Clinical Microbiology and Infectious Diseases.

Extremely high-dose insulin requirement in a diabetic patient with COVID-19: a case report

J. Pugin, K. Gariani, F. Jornayvaz, 2020, BMC Endocrine Disorders.

Streptococcal toxic shock syndrome in the intensive care unit

J. Pugin, X. Roux, B. Huttner, 2018, Annals of Intensive Care.

Mechanical Ventilation Affects Lung Function and Cytokine Production in an Experimental Model of Endotoxemia

B. Chetaille, Y. Jammes, J. Pugin, 2005, Anesthesiology.

Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription

Y. Jammes, J. Pugin, T. Martin, 2002, Respiratory Physiology & Neurobiology.

Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study

B. Souweine, J. Mira, J. Pugin, 2022, Intensive Care Medicine.

Early Measurement of ROX Index in Intermediary Care Unit Is Associated with Mortality in Intubated COVID-19 Patients: A Retrospective Study

J. Pugin, H. Quintard, C. Marti, 2022, Journal of clinical medicine.

Influence of positive end-expiratory pressure (PEEP) on histopathological and bacteriological aspects of pneumonia during low tidal volume mechanical ventilation

J. Pugin, P. Charles, L. Piroth, 2004, Intensive Care Medicine.

Cytokine-mediated inflammation in acute lung injury.

Janet S. Lee, M. Matthay, J. Pugin, 2003, Cytokine & growth factor reviews.

Mechanical ventilation of various human lung cells in vitro: identification of the macrophage as the main producer of inflammatory mediators.

J. Pugin, I. Dunn, 1999, Chest.

The lectin‐like domain of tumor necrosis factor‐α increases membrane conductance in microvascular endothelial cells and peritoneal macrophages

P. De Baetselier, F. G. van der Goot, L. Fransen, 1999, European journal of immunology.

Is the ventilator responsible for lung and systemic inflammation ?

J. Pugin, 2002, Intensive Care Medicine.

Mechanical ventilation and Streptococcus pneumoniae pneumonia alter mitochondrial homeostasis

J. Pugin, P. Charles, L. Piroth, 2018, Scientific Reports.

Procalcitonin is not an accurate marker of spontaneous bacterial peritonitis in patients with cirrhosis.

L. Vadas, L. Spahr, J. Pugin, 2001, Hepato-gastroenterology.

Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial

J. Pugin, B. Ponte, Pierre-Yves Martin, 2015, Critical Care.

LPS binding protein and CD14 in the LPS dependent activation of cells.

J. Gegner, V. Kravchenko, J. Han, 1994, Progress in clinical and biological research.

Granulocyte colony-stimulating factor (G-CSF) downregulates its receptor (CD114) on neutrophils and induces gelatinase B release in humans.

H. Eichler, J. Pugin, B. Jilma, 2000 .

Granulocyte colony‐stimulating factor (G‐CSF) downregulates its receptor (CD114) on neutrophils and induces gelatinase B release in humans

H. Eichler, J. Pugin, B. Jilma, 2000, British journal of haematology.

Brain functional connectivity alterations associated with neuropsychological performance 6–9 months following SARS‐CoV‐2 infection

A. Griffa, R. Ptak, J. Péron, 2022, Human brain mapping.

Nebulized antibiotics for ventilator-associated pneumonia: methodological framework for future multicenter randomized controlled trials

J. Rello, J. Rouby, J. Pugin, 2021, Current opinion in infectious diseases.

Augmented renal clearance, low β-lactam concentrations and clinical outcomes in the critically ill: an observational prospective cohort study.

A. Karmime, J. Pugin, M. Fathi, 2015, International journal of antimicrobial agents.

Year in Review 2007

A. Mebazaa, M. Antonelli, P. Metnitz, 2022 .

mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland

S. Jakob, M. Jeitziner, S. Grazioli, 2022, Intensive Care Medicine.

Year in review in intensive care medicine, 2005. III. Nutrition, pediatric and neonatal critical care, and experimental

M. Antonelli, S. Nava, P. Metnitz, 2006, Intensive Care Medicine.

Year in Review in Intensive Care Medicine, 2006. III. Circulation, ethics, cancer, outcome, education, nutrition, and pediatric and neonatal critical care

M. Antonelli, S. Nava, P. Metnitz, 2007, Intensive Care Medicine.

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

S. Grazioli, J. Pugin, 2018, Front. Immunol..

Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.

R. Ulevitch, J. Pugin, P. Tobias, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Year in review in intensive care medicine, 2004. III. Outcome, ICU organisation, scoring, quality of life, ethics, psychological problems and communication in the ICU, immunity and hemodynamics during sepsis, pediatric and neonatal critical care, experimental studies

M. Antonelli, S. Nava, P. Metnitz, 2005, Intensive Care Medicine.

Activation of human macrophages by mechanical ventilation in vitro.

J. Chevrolet, J. Pugin, D. Tassaux, 1998, American journal of physiology. Lung cellular and molecular physiology.

Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation

François Lemaire, Giuseppe Citerio, Johan Groeneveld, 2009, Intensive Care Medicine.

Cytokine balance in the lungs of patients with acute respiratory distress syndrome.

J. Pugin, K. Steinberg, T. Martin, 2001, American journal of respiratory and critical care medicine.

The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome.

M. Matthay, J. Pugin, M. Widmer, 1999, Critical care medicine.

Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort

M. Antonelli, F. Ruschitzka, T. Welte, 2020, EClinicalMedicine.

Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis.

D. Pittet, L. Vadas, J. Pugin, 2001, American journal of respiratory and critical care medicine.

Extreme elevations of serum lactic dehydrogenase differentiating pulmonary toxoplasmosis from Pneumocystis pneumonia.

P. Vanhems, B. Hirschel, J. Pugin, 1992, The New England journal of medicine.

Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia. A randomized, placebo-controlled, double-blind clinical trial.

R. Auckenthaler, P. Suter, J. Pugin, 1991, JAMA.

Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia

F. Mach, M. Chanson, J. Pugin, 2004, Critical care medicine.

Innate Immune Functions of Immature Neutrophils in Patients With Sepsis and Severe Systemic Inflammatory Response Syndrome*

J. Pugin, P. Tissières, I. Dunn-Siegrist, 2013, Critical care medicine.

Molecules Cells by Synthetic Triacylated Lipid A-like Toll-like Receptor Activation of Human Immunology:

J. Pugin, P. Tissières, I. Dunn-Siegrist, 2014 .

Toll-like Receptor Activation of Human Cells by Synthetic Triacylated Lipid A-like Molecules*

J. Pugin, P. Tissières, I. Dunn-Siegrist, 2012, The Journal of Biological Chemistry.

Toll-like Receptor Activation of Human Cells by Synthetic

J. Pugin, P. Tissières, I. Dunn-Siegrist, 2012 .

Cooperation between PU.1 and CAAT/Enhancer-binding Protein β Is Necessary to Induce the Expression of the MD-2 Gene*

J. Pugin, P. Tissières, I. Dunn-Siegrist, 2009, The Journal of Biological Chemistry.

Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells.

W. Buurman, J. Pugin, R. V. van Suylen, 2008, Molecular Immunology.

Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock.

M. Matthay, J. Pugin, I. Dunn-Siegrist, 2004, Blood.

Gram-negative and Gram-positive bacteria Contribution of Toll-like receptors to the innate immune response to

J. Pugin, I. Dunn-Siegrist, G. Elson, 2013 .

Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria.

J. Pugin, I. Dunn-Siegrist, G. Elson, 2007, Blood.

The crucial role of systemic responses in the innate (non-adaptive) host defense

J. Pugin, R. Munford, Robert S. Munford, 2001, Journal of endotoxin research.

Pivotal Involvement of Fcγ Receptor IIA in the Neutralization of Lipopolysaccharide Signaling via a Potent Novel Anti-TLR4 Monoclonal Antibody 15C1*

J. Pugin, I. Dunn-Siegrist, G. Elson, 2007, Journal of Biological Chemistry.

Validation of a commercially available SARS-CoV-2 serological immunoassay

S. Yerly, I. Guessous, S. Stringhini, 2020, Clinical Microbiology and Infection.

Long COVID neuropsychological deficits after severe, moderate or mild infection

Jordan E. Pierce, R. Ptak, J. Péron, 2021, medRxiv.

Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study

A. Mebazaa, D. Annane, J. Chiche, 2020, Intensive Care Medicine.

Normal responses to injury prevent systemic inflammation and can be immunosuppressive.

J. Pugin, R. Munford, 2001, American journal of respiratory and critical care medicine.

Nonventilatory Management of ARDS

P. Suter, J. Pugin, J. Romand, 1989 .

Compartmentalization of the Inflammatory Response during Acute Pancreatitis Correlation with Local and Systemic Complications Sampling Protocol and Cytokine Assays

J. Pugin, P. Laterre, D. Latinne, 2022 .

French Intensive Care Society, International congress – Réanimation 2016

Paul P. Tallon, Stéphane Huot, B. Souweine, 2016, Annals of Intensive Care.

Diagnostic bronchoalveolar lavage in patients with pneumonia produces sepsis-like systemic effects

P. Suter, J. Pugin, 2005, Intensive Care Medicine.

Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy

N. Roche, C. Brun-Buisson, J. Pugin, 2013, Annals of Intensive Care.

Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid.

R. Auckenthaler, P. Suter, J. Pugin, 1991, The American review of respiratory disease.

ESICM LIVES 2016: part two

A. M. Cavalheiro, H. S. King, M. M. Moraes, 2016, Intensive Care Medicine Experimental.

Clinical features and viral kinetics in a rapidly cured patient with Ebola virus disease: a case report.

Tom J. Petty, E. Zdobnov, S. Yerly, 2015, The Lancet. Infectious diseases.

The 2014–2015 Ebola outbreak in West Africa: Hands On

B. Allegranzi, D. Pittet, A. Calmy, 2016, Antimicrobial Resistance & Infection Control.

Endocan, a new endothelial marker in human sepsis*

J. Pugin, M. Jourdain, B. Cavestri, 2006, Critical care medicine.

Is Dressler syndrome dead?

J. Pugin, K. Bendjelid, 2004, Chest.

Pulmonary Edema Fluid from Patients with Early Lung Injury Stimulates Fibroblast Proliferation through IL-1β-Induced IL-6 Expression 1

M. Matthay, J. Pugin, L. Ware, 2004, The Journal of Immunology.

Expression-Induced IL-6 β Proliferation through IL-1 Early Lung Injury Stimulates Fibroblast Pulmonary Edema Fluid from Patients with Pugin and

M. Matthay, J. Pugin, L. Ware, 2004 .

Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism.

T. Geiser, M. Matthay, J. Pugin, 2001, American journal of respiratory and critical care medicine.

Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS

S. Grazioli, J. Pugin, P. Charles, 2019, PloS one.

Single cell profiling in COVID-19 associated acute kidney injury reveals patterns of tubule injury and repair in human

A. McMahon, S. de Seigneux, J. Pugin, 2021, bioRxiv.

Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality

S. de Seigneux, J. Pugin, K. Gariani, 2020, Nature Metabolism.

Unsupervised clustering reveals phenotypes of AKI in ICU COVID-19 patients

J. Pugin, G. Criton, D. Legouis, 2022, Frontiers in Medicine.

Evolving Concepts in Sepsis and Septic Shock

J. Pugin, P. Eichacker, 2001, Perspectives on Critical Care Infectious Diseases.

Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood.

B. Borisch, L. Spahr, J. Pugin, 2001, Journal of hepatology.

Measured and Estimated Glomerular Filtration Rate in the ICU: A Prospective Study.

S. de Seigneux, J. Pugin, D. Legouis, 2020, Critical care medicine.

Kinetic GFR Outperforms CKD-EPI for Slow Graft Function Prediction in the Immediate Postoperative Period Following Kidney Transplantation

T. Berney, S. de Seigneux, J. Pugin, 2020, Journal of clinical medicine.

The Role of the Macrophage

J. Pugin, 2007 .

Local inflammatory responses following bronchial endotoxin instillation in humans.

S. Banks, J. Pugin, A. Suffredini, 2001, American journal of respiratory and critical care medicine.

Growth Cyclic Stretch of Human Lung Cells Induces an Acidification

D. Gaver, S. Margulies, A. Malik, 2002 .

β-Adrenergic agonists exert their “anti-inflammatory” effects in monocytic cells through the IκB/NF-κB pathway

J. Pugin, P. Farmer, 2000 .

Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure.

T. Perneger, S. de Seigneux, J. Pugin, 2006, Kidney international.

Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study

Stephan Harbarth, Bara Ricou, Didier Pittet, 2006, Critical care.

Traitement du choc septique par épuration extracorporelle de l’endotoxine circulante

J. Pugin, G. Pavlovic, Mia Gisselbaek, 2013 .

Mental health outcomes of ICU and non-ICU healthcare workers during the COVID-19 outbreak: a cross-sectional study

J. Pugin, L. Benzakour, Rafaël Weissbrodt, 2021, Annals of Intensive Care.

Prompt antibiotic administration and goal-directed hemodynamic support in patients with severe sepsis and septic shock

J. Pugin, F. Sarasin, V. Nobre, 2007, Current opinion in critical care.

SPHN/PHRT: Forming a Swiss-Wide Infrastructure for Data-Driven Sepsis Research

Gunnar Rätsch, Karsten Borgwardt, Peter Bühlmann, 2020, MIE.

Burden of illness imposed by severe sepsis in Switzerland.

S. Marsch, J. Chevrolet, J. Pugin, 2004, Swiss medical weekly.

Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study.

A. Rougemont, L. Spahr, J. Pugin, 2002, Journal of hepatology.

Identification of respiratory microbiota markers in ventilator-associated pneumonia

J. Schrenzel, V. Lazarevic, J. Pugin, 2019, Intensive Care Medicine.

Increased FGF21 plasma levels in humans with sepsis and SIRS

J. Pugin, K. Gariani, F. Jornayvaz, 2013, Endocrine connections.

Easy-to-prescribe nutrition support in the intensive care in the era of COVID-19

C. Pichard, L. Genton, J. Pugin, 2020, Clinical Nutrition ESPEN.

Molecular mechanisms of lung cell activation induced by cyclic stretch

J. Pugin, 2003, Critical care medicine.

Clinical Metagenomics for the Diagnosis of Hospital-acquired Infections: Promises and Hurdles.

J. Schrenzel, V. Lazarevic, J. Pugin, 2017, American journal of respiratory and critical care medicine.

Year in review in Intensive Care Medicine 2010: II. Pneumonia and infections, cardiovascular and haemodynamics, organization, education, haematology, nutrition, ethics and miscellanea

A. Mebazaa, M. Antonelli, M. Bonten, 2011, Intensive Care Medicine.

Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

D. Brealey, J. Pugin, C. Guitton, 2021, Critical Care.

Immune monitoring of patients with septic shock by measurement of intraleukocyte cytokines

J. Pugin, T. Fumeaux, J. Dufour, 2004, Intensive Care Medicine.

Early prone positioning in acute respiratory distress syndrome related to COVID-19: a propensity score analysis from the multicentric cohort COVID-ICU network—the ProneCOVID study

A. Mebazaa, D. Annane, J. Chiche, 2022, Critical Care.

Early Prone Positioning in Acute Respiratory Distress Syndrome Related to COVID-19: A Propensity Score Analysis from the Multicentric Cohort COVID-ICU network. The ProneCOVID Study.

J. Pugin, C. Guérin, D. Hajage, 2021 .

Preparedness and Reorganization of Care for Coronavirus Disease 2019 Patients in a Swiss ICU: Characteristics and Outcomes of 129 Patients

D. Pugin, A. Gayet-Ageron, M. Tramèr, 2020, Critical care explorations.

Innate Immune Deficiency of Extremely Premature Neonates Can Be Reversed by Interferon-γ

J. Pugin, M. Berner, R. Pfister, 2012, PloS one.

Toll-Like Receptors

J. Pugin, 2001 .

Mechanisms of Cellular Activation by Endotoxin1

R. Ulevitch, J. Pugin, P. Tobias, 1995 .

Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis*

S. de Seigneux, J. Pugin, K. Bendjelid, 2021, Critical care medicine.

Tumor necrosis factor-alpha and interleukin-1 beta mediate human endothelial cell activation in blood at low endotoxin concentrations.

R. Ulevitch, J. Pugin, P. Tobias, 1995, Journal of inflammation.

Year in review in Intensive Care Medicine, 2007. III. Ethics and legislation, health services research, pharmacology and toxicology, nutrition and paediatrics

A. Mebazaa, M. Antonelli, P. Metnitz, 2008, Intensive Care Medicine.

Activation of human macrophages by mechanical ventilation in vitro.

J. Chevrolet, J. Pugin, D. Tassaux, 1998, The American journal of physiology.

Use of high-volume haemodiafiltration in patients with refractory septic shock and acute kidney injury

J. Pugin, B. Ponte, Pierre-Yves Martin, 2012, Clinical kidney journal.

Challenges in the culture-independent analysis of oral and respiratory samples from intubated patients

J. Schrenzel, J. Veyrieras, V. Lazarevic, 2014, Front. Cell. Infect. Microbiol..

First case of Candida auris in Switzerland: discussion about preventive strategies.

A. Bizzini, J. Pugin, S. Harbarth, 2018, Swiss medical weekly.

Influenza-associated aspergillosis in critically-ill patients—a retrospective bicentric cohort study

J. Schrenzel, J. Pugin, K. Boggian, 2020, European Journal of Clinical Microbiology & Infectious Diseases.

Acute portal hemodynamics and cytokine changesfollowing selective transarterial chemoembolization in patients with cirrhosis and hepatocellular carcinoma.

P. Majno, L. Spahr, J. Pugin, 2003, Medical science monitor : international medical journal of experimental and clinical research.

Year in review in intensive care medicine, 2004. II. Brain injury, hemodynamic monitoring and treatment, pulmonary embolism, gastrointestinal tract, and renal failure

M. Antonelli, S. Nava, P. Metnitz, 2005, Intensive Care Medicine.

Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study

A. Mebazaa, D. Annane, J. Chiche, 2021, Annals of intensive care.

Clinical signs and scores for the diagnosis of ventilator-associated pneumonia.

J. Pugin, 2002, Minerva anestesiologica.

Predicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores

A. Mebazaa, D. Annane, J. Chiche, 2021, Annals of Intensive Care.

Functional connectivity underlying cognitive and psychiatric symptoms in post-COVID-19 syndrome: is anosognosia a key determinant?

A. Griffa, J. Péron, D. Van de Ville, 2022, Brain communications.

Is the measurement of monocytes HLA-DR expression useful in patients with sepsis?

J. Pugin, T. Fumeaux, 2006, Intensive Care Medicine.

Impact of nutritional therapy during the first wave of the COVID-19 pandemic in intensive care patients: A retrospective observational study

L. Genton, J. Pugin, C. Heidegger, 2021, Clinical Nutrition.

How Can We Help Healthcare Workers during a Catastrophic Event Such as the COVID-19 Pandemic?

J. Pugin, L. Benzakour, Rafaël Weissbrodt, 2022, Healthcare.

Hemodynamics in experimental gastric juice induced aspiration pneumonitis

J. Gaudart, J. Pugin, L. Papazian, 2007, Intensive Care Medicine.

Effect of therapeutic anticoagulation on gas exchange in mechanically ventilated COVID-19 patients: A secondary analysis of the COVID-HEP trial

L. Mazzolai, C. Combescure, A. Calmy, 2023, Thrombosis Research.

The IASIS, INHALE and VAPORISE trials. Reasons for a triple failure: study design, aminoglycosides dosing and technique of nebulisation.

J. Rouby, J. Pugin, O. Mimoz, 2020, Anaesthesia, critical care & pain medicine.

Ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: understanding nebulization of aminoglycosides and colistin

J. Rello, T. Welte, J. Rouby, 2020, Intensive Care Medicine.

Year in review in Intensive Care Medicine 2009: I. Pneumonia and infections, sepsis, outcome, acute renal failure and acid base, nutrition and glycaemic control

A. Mebazaa, M. Antonelli, F. Lemaire, 2010, Intensive Care Medicine.

Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals

A. Mebazaa, D. Annane, J. Chiche, 2021, Critical Care.

Brief summary of French guidelines for the prevention, diagnosis and treatment of hospital-acquired pneumonia in ICU

L. Bouadma, J. Pugin, L. Velly, 2018, Annals of Intensive Care.

Excessive inflammatory and metabolic responses to acute SARS-CoV-2 infection are associated with a distinct gut microbiota composition

P. O’Toole, L. O’Mahony, J. Pugin, 2021, bioRxiv.

Impact of a multifaceted prevention program on ventilator-associated pneumonia including selective oropharyngeal decontamination

M. Abbas, C. Landelle, J. Pugin, 2018, Intensive Care Medicine.

Year in review in Intensive Care Medicine, 2006. II. Infections and sepsis, haemodynamics, elderly, invasive and noninvasive mechanical ventilation, weaning, ARDS

M. Antonelli, S. Nava, P. Metnitz, 2007, Intensive Care Medicine.

Mechanical ventilation and Streptococcus pneumoniae pneumonia alter mitochondrial homeostasis

J. Pugin, P. Charles, L. Piroth, 2018, Scientific Reports.

Acute TNFα levels predict cognitive impairment 6–9 months after COVID-19 infection

A. Griffa, F. Assal, I. Guessous, 2023, Psychoneuroendocrinology.

Frequency of Abnormally Low Neuropsychological Scores in Post-COVID-19 Syndrome: the Geneva COVID-COG Cohort

R. Ptak, J. Péron, F. Assal, 2022, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

Markers of limbic system damage following SARS-CoV-2 infection

A. Griffa, D. Van de Ville, F. Assal, 2023, Brain communications.

Diclofenac Sodium for Fever Control in Neurocritical Care: A Systematic Review

J. Pugin, H. Quintard, M. Watchi, 2023, Journal of clinical medicine.

Can calculation of energy expenditure based on CO2 measurements replace indirect calorimetry?

C. Pichard, L. Genton, J. Pugin, 2017, Critical Care.

Bacteremia, sepsis and shock

J. Pugin, 2005, Intensive Care Medicine.

Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teaching

A. Mebazaa, M. Antonelli, F. Lemaire, 2010, Intensive Care Medicine.

Characteristics and prognosis of bloodstream infection in patients with COVID-19 admitted in the ICU: an ancillary study of the COVID-ICU study

A. Mebazaa, D. Annane, J. Chiche, 2021, Annals of Intensive Care.

Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial.

H. Goossens, M. Bonten, H. Jafri, 2021, Lancet. Infectious Diseases (Print).

Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia

A. Mebazaa, M. Antonelli, P. Metnitz, 2008, Intensive Care Medicine.

Biomarkers of sepsis: is procalcitonin ready for prime time?

J. Pugin, 2002, Intensive Care Medicine.

Immunostimulation is a rational therapeutic strategy in sepsis.

J. Pugin, 2007, Novartis Foundation symposium.

[ The intestine-liver-lung axis in septic syndrome].

J. Chevrolet, J. Pugin, 1991, Schweizerische medizinische Wochenschrift.

Limitation of life-sustaining therapies in critically ill patients with COVID-19: a descriptive epidemiological investigation from the COVID-ICU study

A. Mebazaa, D. Annane, J. Chiche, 2023, Critical Care.

Erratum to: Can calculation of energy expenditure based on CO2 measurements replace indirect calorimetry?

C. Pichard, L. Genton, J. Pugin, 2017, Critical Care.

Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients

I. Guessous, S. Stringhini, J. Pugin, 2023, Nutrients.

S. Hunziker, S. Marsch, G. D. De Marchis, 2023, Critical Care.

Profiling genes in the ICU: Are we there yet?

J. Pugin, 2008, Intensive Care Medicine.

Mapping the human genetic architecture of COVID-19

Eurie L. Hong, E. F. Perez, Rachel G Liao, 2021 .

Decreased CRRT Filter Lifespan in COVID-19 ICU Patients

J. Pugin, C. Heidegger, D. Legouis, 2021, Journal of clinical medicine.

Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro.

J. Pugin, T. Brann, Simeon E. Goldblum, 1994, The Journal of clinical investigation.

Compartmentalization of the inflammatory response during acute pancreatitis: correlation with local and systemic complications.

J. Pugin, P. Laterre, D. Latinne, 2003, American journal of respiratory and critical care medicine.

Hospital-acquired pneumonia in ICU.

L. Bouadma, J. Pugin, L. Velly, 2017, Anaesthesia, critical care & pain medicine.

Toll-like Receptor Activation of Human Cells by Synthetic Triacylated Lipid A-like Molecules*

J. Pugin, P. Tissières, I. Dunn-Siegrist, 2012, The Journal of Biological Chemistry.