Lin Xie

发表

[11C]DAC-PET for Noninvasively Monitoring Neuroinflammation and Immunosuppressive Therapy Efficacy in Rat Experimental Autoimmune Encephalomyelitis Model

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2012, Journal of Neuroimmune Pharmacology.

Synthesis and evaluation of 4-halogeno-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-[11C]methylbenzamide for imaging of metabotropic glutamate 1 receptor in melanoma.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2015, Journal of medicinal chemistry.

Synthesis and Evaluation of Novel Radioligands Based on 3-[5-(Pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 5.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2016, Journal of medicinal chemistry.

Synthesis and evaluation of novel radioligands for positron emission tomography imaging of metabotropic glutamate receptor subtype 1 (mGluR1) in rodent brain.

Lin Xie, Kazunori Kawamura, Toshimitsu Fukumura, 2012, Journal of medicinal chemistry.

Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 (mGluR1) Using [11C]ITMM with Ultra-High Specific Activity in Small-Animal PET

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2015, PloS one.

Utilization of [11C]phosgene for radiosynthesis of N-(2-{3-[3,5-bis(trifluoromethyl)]phenyl[11C]ureido}ethyl)glycyrrhetinamide, an inhibitory agent for proteasome and kinase in tumors.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2012, Bioorganic & medicinal chemistry letters.

Radiosynthesis of three [11C]ureido-substituted benzenesulfonamides as PET probes for carbonic anhydrase IX in tumors.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2011, Bioorganic & medicinal chemistry letters.

In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies.

Lu Wang, Lin Xie, Mary Jo Ondrechen, 2018, Journal of medicinal chemistry.

Radiosynthesis and evaluation of a novel monoacylglycerol lipase radiotracer: 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-benzyl-1H-pyrazol-3-yl)azetidine-1-[11C]carboxylate.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2019, Bioorganic & medicinal chemistry.

Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase

Lu Wang, Lin Xie, Steven H. Liang, 2016, Theranostics.

Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2).

Steven H. Liang, Ming-Rong Zhang, D. Sheffler, 2020, Journal of medicinal chemistry.

Synthesis and evaluation of 1-(cyclopropylmethyl)-4-(4-[11C]methoxyphenyl)-piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([11C]CMDC) for PET imaging of metabotropic glutamate receptor 2 in the rat brain.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2017, Bioorganic & medicinal chemistry.

Development of a 18F-Labeled Radiotracer with Improved Brain Kinetics for Positron Emission Tomography Imaging of Translocator Protein (18 kDa) in Ischemic Brain and Glioma.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2017, Journal of medicinal chemistry.

Synthesis and evaluation of new (18)F-labelled acetamidobenzoxazolone-based radioligands for imaging of the translocator protein (18 kDa, TSPO) in the brain.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2014, Organic & biomolecular chemistry.

Characterization of a novel acetamidobenzoxazolone‐based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain

Ming-Rong Zhang, J. Maeda, Lin Xie, 2014, Journal of neurochemistry.

18F-FEDAC as a Targeting Agent for Activated Macrophages in DBA/1 Mice with Collagen-Induced Arthritis: Comparison with 18F-FDG

G. Cheon, Ming-Rong Zhang, K. Kang, 2018, The Journal of Nuclear Medicine.

Synthesis of two novel [18F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2018, Organic & biomolecular chemistry.

[18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain

Ming-Rong Zhang, J. Maeda, M. Higuchi, 2015, Theranostics.

[18F]FPBMP: – a potential new positron emission tomography radioligand for imaging of translocator protein (18 kDa) in peripheral organs of rats

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2015 .

In Vivo Measurement of the Affinity and Density of Metabotropic Glutamate Receptor Subtype 1 in Rat Brain Using 18F-FITM in Small-Animal PET

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2012, The Journal of Nuclear Medicine.

PET Imaging of Lung Inflammation with [18F]FEDAC, a Radioligand for Translocator Protein (18 kDa)

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2012, PloS one.

PET brain kinetics studies of (11)C-ITMM and (11)C-ITDM,radioprobes for metabotropic glutamate receptor type 1, in a nonhuman primate.

Lin Xie, Yuji Nagai, Joji Yui, 2014, American journal of nuclear medicine and molecular imaging.

Binding potential of (E)-[¹¹C]ABP688 to metabotropic glutamate receptor subtype 5 is decreased by the inclusion of its ¹¹C-labelled Z-isomer.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2014, Nuclear medicine and biology.

Evaluation of the novel TSPO radiotracer 2-(7-butyl-2-(4-(2-([18F]fluoroethoxy)phenyl)-5-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide in a preclinical model of neuroinflammation.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2018, European journal of medicinal chemistry.

Synthesis, metabolite analysis, and in vivo evaluation of [(11)C]irinotecan as a novel positron emission tomography (PET) probe.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2013, Nuclear medicine and biology.

Design, synthesis and biological evaluation of small molecule-based PET radioligands for the 5-hydroxytryptamine 7 receptor

Pooja, Ming-Rong Zhang, Lin Xie, 2015 .

Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2013, EJNMMI Research.

Monitoring Neuroprotective Effects Using Positron Emission Tomography With [11C]ITMM, a Radiotracer for Metabotropic Glutamate 1 Receptor

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2013, Stroke.

PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy

Ming-Rong Zhang, Lin Xie, Lingling Xu, 2022, Materials today. Bio.

Synthesis and preliminary studies of a novel negative allosteric modulator [11C]QCA for imaging of metabotropic glutamate receptor 2

Steven H. Liang, Ming-Rong Zhang, D. Sheffler, 2017 .

A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network

Steven H. Liang, L. Josephson, Ming-Rong Zhang, 2022, Acta Pharmacologica Sinica.

Radiosynthesis and in vivo evaluation of 11C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2019, EJNMMI Radiopharmacy and Chemistry.

Characterization and clinical significance of the CADM1/HER2/STAT3 axis in serous ovarian tumors

Lin Xie, Jianbin Zhou, Dan Wu, 2021, Medicine.

PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide

Ming-Rong Zhang, Lin Xie, Kuan Hu, 2020, ACS omega.

[18F]DAA1106: Automated radiosynthesis using spirocyclic iodonium ylide and preclinical evaluation for positron emission tomography imaging of translocator protein (18 kDa).

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2018, Bioorganic & medicinal chemistry.

A useful PET probe [11C]BU99008 with ultra-high specific radioactivity for small animal PET imaging of I2-imidazoline receptors in the hypothalamus.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2017, Nuclear medicine and biology.

Radiosynthesis and preliminary PET evaluation of glycogen synthase kinase 3β (GSK-3β) inhibitors containing [(11)C]methylsulfanyl, [(11)C]methylsulfinyl or [(11)C]methylsulfonyl groups.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2015, Bioorganic & medicinal chemistry letters.

Development of the Fibronectin-Mimetic Peptide KSSPHSRN(SG)5RGDSP as a Novel Radioprobe for Molecular Imaging of the Cancer Biomarker α5β1 Integrin.

Ming-Rong Zhang, Y. Fujibayashi, T. Saga, 2015, Biological & pharmaceutical bulletin.

Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography.

Steven H. Liang, S. Tomita, Ming-Rong Zhang, 2022, Journal of medicinal chemistry.

Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2

Steven H. Liang, Ming-Rong Zhang, D. Sheffler, 2020, Theranostics.

Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET.

Steven H. Liang, L. Josephson, Ming-Rong Zhang, 2019, Bioorganic & medicinal chemistry letters.

Development of [(11)C]MFTC for PET imaging of fatty acid amide hydrolase in rat and monkey brains.

Ming-Rong Zhang, J. Maeda, Yuji Nagai, 2015, ACS chemical neuroscience.

Radiosynthesis and evaluation of N-(3,4-dimethylisoxazol-5-yl)piperazine-4-[4-(4-fluorophenyl)thiazol-2-yl]-1-[11C]carboxamide for in vivo positron emission tomography imaging of fatty acid amide hydrolase in brain

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2015 .

Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation.

Ming-Rong Zhang, Lin Xie, Yiding Zhang, 2019, Chemical communications.

Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a).

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2017, Nuclear medicine and biology.

Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2019, Bioorganic & medicinal chemistry.

Identification and Development of A New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[ 11 C]methoxyphenyl)-5-((1-methyl-1 H -pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu 2 )

Steven H. Liang, Ming-Rong Zhang, D. Sheffler, 2021 .

Change in the Binding of [11C]BU99008 to Imidazoline I2 Receptor Using Brain PET in Zucker Rats

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2019, Molecular Imaging and Biology.

In vivo evaluation of a new ¹⁸F-labeled PET ligand, [¹⁸F]FEBU, for the imaging of I₂-imidazoline receptors.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2015, Nuclear medicine and biology.

imaging of I 2 -imidazoline receptors

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2015 .

131I-IITM and 211At-AITM: Two Novel Small-Molecule Radiopharmaceuticals Targeting Oncoprotein Metabotropic Glutamate Receptor 1

Ming-Rong Zhang, Lin Xie, Kuan Hu, 2020, The Journal of Nuclear Medicine.

Synthesis and evaluation of 1-[2-(4-[(11)C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2013, Bioorganic & medicinal chemistry.

Boron agents for neutron capture therapy

Steven H. Liang, L. Josephson, Ming-Rong Zhang, 2020 .

Visualization of Acute Liver Damage Induced by Cycloheximide in Rats Using PET with [18F]FEDAC, a Radiotracer for Translocator Protein (18 kDa)

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2014, PloS one.

Molecular imaging of ectopic metabotropic glutamate 1 receptor in melanoma with a positron emission tomography radioprobe 18F‐FITM

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2014, International journal of cancer.

Synthesis and evaluation of [64Cu]PSMA-617 targeted for prostate-specific membrane antigen in prostate cancer.

Ming-Rong Zhang, Lin Xie, A. Hatori, 2017, American journal of nuclear medicine and molecular imaging.

Pharmacokinetic Evaluation of [11C]CEP-32496 in Nude Mice Bearing BRAFV600E Mutation-Induced Melanomas

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2018, Molecular imaging.

[(11)C-carbonyl]CEP-32496: radiosynthesis, biodistribution and PET study of brain uptake in P-gp/BCRP knockout mice.

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2014, Bioorganic & medicinal chemistry letters.

PET imaging of apoptosis in tumor-bearing mice and rabbits after paclitaxel treatment with (18)F(-)Labeled recombinant human His10-annexin V.

Ming-Rong Zhang, Lin Xie, Zi-chun Hua, 2015, American journal of nuclear medicine and molecular imaging.

Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint

Ming-Rong Zhang, Lin Xie, Weizhi Wang, 2020, RSC chemical biology.

Whole-body PET tracking of a d-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors

Ming-Rong Zhang, Zigang Li, Kuan Hu, 2021, Acta pharmaceutica Sinica. B.

Development of 1-N-11C-Methyl-l- and -d-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan

Ming-Rong Zhang, T. Suhara, J. Maeda, 2015, Scientific Reports.

Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy

Ming-Rong Zhang, Yihai Cao, T. Shimokawa, 2021, Journal for ImmunoTherapy of Cancer.

Automated Synthesis of (rac)‐, (R)‐, and (S)‐[18F]Epifluorohydrin and Their Application for Developing PET Radiotracers Containing a 3‐[18F]Fluoro‐2‐hydroxypropyl Moiety

Ming-Rong Zhang, Lin Xie, Tomoteru Yamasaki, 2018, ChemMedChem.

Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy

Steven H. Liang, Ming-Rong Zhang, O. Farokhzad, 2020, Nature Communications.

Radiosynthesis, Photoisomerization, Biodistribution, and Metabolite Analysis of 11C-PBB3 as a Clinically Useful PET Probe for Imaging of Tau Pathology

Lin Xie, Satoshi Shiomi, Kazunori Kawamura, 2014, The Journal of Nuclear Medicine.

Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton.

Steven H. Liang, L. Josephson, Ming-Rong Zhang, 2019, Journal of medicinal chemistry.

Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study

Lin Xie, Satoshi Shiomi, Hidekatsu Wakizaka, 2016, The Journal of Neuroscience.

Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2.

Steven H. Liang, Ming-Rong Zhang, D. Sheffler, 2017, ACS chemical neuroscience.

Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein.

Steven H. Liang, Patrick J. Dunn, S. Tomita, 2018, European journal of medicinal chemistry.

Synthesis and in vitro evaluation of three novel radiotracers for imaging of metabotropic glutamate receptor subtype 2 in rat brain.

Lin Xie, Tomoteru Yamasaki, K. Kumata, 2017, Bioorganic & medicinal chemistry letters.

Noninvasive Quantification of Metabotropic Glutamate Receptor Type 1 with [11C]ITDM: a Small-Animal PET Study

Lin Xie, Hidekatsu Wakizaka, Kazunori Kawamura, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11C]DAC-PET for Noninvasively Monitoring Neuroinflammation and Immunosuppressive Therapy Efficacy in Rat Experimental Autoimmune Encephalomyelitis Model

Lin Xie, Tomoteru Yamasaki, N. Ichimaru, 2012, Journal of Neuroimmune Pharmacology.

Translocator protein (18 kDa), a potential molecular imaging biomarker for non-invasively distinguishing non-alcoholic fatty liver disease.

Lin Xie, Tomoteru Yamasaki, Joji Yui, 2012, Journal of hepatology.

N-(3,4-Dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[(11)C]methylphenyl)thiazol-2-yl]-1-carboxamide: A promising positron emission tomography ligand for fatty acid amide hydrolase.

Lin Xie, Tomoteru Yamasaki, Joji Yui, 2016, Bioorganic & medicinal chemistry.

Development of a Stable Peptide-Based PET Tracer for Detecting CD133-Expressing Cancer Cells

Lin Xie, Kuan Hu, Hisashi Suzuki, 2021, ACS omega.

Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators

Steven H. Liang, L. Josephson, Lin Xie, 2020, Acta Pharmacologica Sinica.

Development of 2-(2-(3-(4-([18F]Fluoromethoxy- d2)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione for Positron-Emission-Tomography Imaging of Phosphodiesterase 10A in the Brain.

Lin Xie, Tomoteru Yamasaki, K. Kumata, 2018, Journal of medicinal chemistry.

Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators

Steven H. Liang, L. Josephson, Lin Xie, 2020, Acta Pharmacologica Sinica.

Development of N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[11C]methylbenzamide for positron emission tomography imaging of metabotropic glutamate 1 receptor in monkey brain.

J. Maeda, Yuji Nagai, Lin Xie, 2012, Journal of medicinal chemistry.

Linear Peptide-Based PET Tracers for Imaging PD-L1 in Tumors.

Lin Xie, Kuan Hu, Yiding Zhang, 2023, Molecular pharmaceutics.

Utility of Translocator Protein (18 kDa) as a Molecular Imaging Biomarker to Monitor the Progression of Liver Fibrosis

Lin Xie, Tomoteru Yamasaki, Joji Yui, 2015, Scientific Reports.

Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)C]methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4).

Lin Xie, Tomoteru Yamasaki, Joji Yui, 2016, Bioorganic & medicinal chemistry letters.

Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold.

Steven H. Liang, R. Carson, B. Cravatt, 2021, Journal of medicinal chemistry.

The Glutaminase-1 Inhibitor [11C-carbony]BPTES: Synthesis and Positron Emission Tomography Study in Mice

Lin Xie, K. Kumata, Yiding Zhang, 2023, Pharmaceuticals.

Efficient radiosynthesis and non-clinical safety tests of the TSPO radioprobe [(18)F]FEDAC: Prerequisites for clinical application.

Y. Fujibayashi, Lin Xie, Tomoteru Yamasaki, 2016, Nuclear medicine and biology.

A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy

T. Shimokawa, Lin Xie, Kuan Hu, 2023, Cell reports. Medicine.

Synthesis of two novel [18F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain.

Lin Xie, Tomoteru Yamasaki, K. Kumata, 2018, Organic & biomolecular chemistry.

Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation.

Lin Xie, Yiding Zhang, Suzuki Hisashi, 2019, Chemical communications.

211At-Labeled Polymer Nanoparticles for Targeted Radionuclide Therapy of Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)-Overexpressed Cancer.

Kai Yang, Lin Xie, Feng Wang, 2021, Bioconjugate chemistry.