D. R. Linden

发表

Duodenal mucosal secretory disturbances in functional dyspepsia

M. Grover, Susrutha Puthanmadhom Narayanan, D. R. Linden, 2020, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Bacterially Derived Tryptamine Increases Mucus Release by Activating a Host Receptor in a Mouse Model of Inflammatory Bowel Disease

M. Fischbach, J. Sonnenburg, G. Farrugia, 2020, iScience.

Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience.

Michael J Ackerman, Eric D Wieben, Gianrico Farrugia, 2016, Mayo Clinic proceedings.

Carbon monoxide reverses diabetic gastroparesis in NOD mice.

G. Farrugia, J. Szurszewski, K. M. Choi, 2010, American journal of physiology. Gastrointestinal and liver physiology.

Expression of RAD21 immunoreactivity in myenteric neurons of the human and mouse small intestine

E. Bonora, G. Farrugia, D. R. Linden, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Bicarbonate ion transport by the electrogenic Na+/HCO3− cotransporter, NBCe1, is required for normal electrical slow‐wave activity in mouse small intestine

M. Romero, G. Farrugia, D. R. Linden, 2021, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Extracellular Cl− regulates electrical slow waves and setting of smooth muscle membrane potential by interstitial cells of Cajal in mouse jejunum

G. Farrugia, J. Szurszewski, D. R. Linden, 2018, Experimental physiology.

Walker 256 tumor‐bearing rats demonstrate altered interstitial cells of Cajal. Effects on ICC in the Walker 256 tumor model

D. R. Linden, F. Guarnier, J. Zanoni, 2016, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Hydrogen Sulfide Is a Partially Redox-independent Activator of the Human Jejunum Na Ϩ Channel, Na V 1.5

M. Kendrick, G. Farrugia, J. Szurszewski, 2022 .

J. Sonnenburg, G. Farrugia, J. Szurszewski, 2016, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Altered Expression of Ano1 Variants in Human Diabetic Gastroparesis*

P. Pasricha, H. Parkman, G. Farrugia, 2011, The Journal of Biological Chemistry.

Passive siRNA transfection method for gene knockdown in air-liquid interface airway epithelial cell cultures.

Y. Prakash, D. R. Linden, S. Chiarella, 2021, American journal of physiology. Lung cellular and molecular physiology.

Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome.

M. Crowell, H. Blaszyk, D. R. Linden, 2004, Gastroenterology.

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production.

G. Farrugia, M. Grover, D. R. Linden, 2017, American journal of physiology. Gastrointestinal and liver physiology.

Diabetic neuropathy: an evaluation of the use of quercetin in the cecum of rats.

D. R. Linden, J. Zanoni, N. C. Buttow, 2013, World journal of gastroenterology.

Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells

J. Sonnenburg, G. Farrugia, J. Szurszewski, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice

G. Farrugia, A. Lorincz, M. Kuro-o, 2010, The Journal of physiology.

Microglial derived nitric oxide decreases serotonin content in rat basophilic leukemia (RBL-2H3) cells.

D. R. Linden, E. El-Fakahany, 2002, European journal of pharmacology.

Differential effects in CGRPergic, nitrergic, and VIPergic myenteric innervation in diabetic rats supplemented with 2% L-glutamine.

D. R. Linden, J. Zanoni, R. Pereira, 2016, Anais da Academia Brasileira de Ciencias.

Cyclooxygenase‐2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon

D. R. Linden, K. Sharkey, G. Mawe, 2004, The Journal of physiology.

Hydrogen sulfide signaling in the gastrointestinal tract.

D. R. Linden, 2014, Antioxidants & redox signaling.

Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging

G. Farrugia, A. Lorincz, M. Kuro-o, 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Neurogastroenterology and Motility Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT 3 receptor expression via acetate production

G. Farrugia, M. Grover, D. R. Linden, 2017 .

Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer

S. Haeryfar, F. Gounari, M. Singh, 2019, Front. Immunol..

Serotonin transporter function and expression are reduced in mice with TNBS‐induced colitis

D. R. Linden, K. Sharkey, G. Mawe, 2005, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis.

D. R. Linden, K. Sharkey, G. Mawe, 2004, American journal of physiology. Gastrointestinal and liver physiology.

ENTEROENDOCRINE CELLS AND SEROTONIN AVAILABILITY ARE ALTERED IN THE MUCOSA OF GUINEA PIGS WITH TNBS ILEITIS

D. R. Linden, K. Sharkey, G. Mawe, 2004 .

On the fiftieth anniversary Postinfectious irritable bowel syndrome: mechanisms related to pathogens

M. Camilleri, G. Farrugia, M. Grover, 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Changes in colonic motility and the electrophysiological properties of myenteric neurons persist following recovery from trinitrobenzene sulfonic acid colitis in the guinea pig

D. R. Linden, K. Sharkey, G. Mawe, 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.

G. Farrugia, D. R. Linden, S. Gibbons, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Neuroplasticity and dysfunction after gastrointestinal inflammation

D. R. Linden, S. Brierley, 2014, Nature Reviews Gastroenterology &Hepatology.

Enhanced excitability of myenteric AH neurones in the inflamed guinea‐pig distal colon

D. R. Linden, K. Sharkey, G. Mawe, 2003, The Journal of physiology.

Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses

D. R. Linden, S. Brierley, L. Blackshaw, 2009, Gut.

Indiscriminate loss of myenteric neurones in the TNBS‐inflamed guinea‐pig distal colon

H. Blaszyk, D. R. Linden, K. Sharkey, 2005, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Linaclotide – a secretagogue and antihyperalgesic agent – what next?

D. R. Linden, A. Bharucha, A. E. Bharucha, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Diabetic Csf1op/op Mice Lacking Macrophages Are Protected Against the Development of Delayed Gastric Emptying

G. Farrugia, J. Szurszewski, K. M. Choi, 2015, Cellular and Molecular Gastroenterology and Hepatology.

276 Treatment With IL-10 Reverses Gastroparesis in Diabetic NOD/Shiltj Mice

G. Farrugia, J. Szurszewski, K. M. Choi, 2012 .

Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice.

Daniel S. Yang, G. Farrugia, J. Szurszewski, 2018, Gastroenterology.

Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying.

M. Kendrick, B. Rubin, G. Farrugia, 2017, Gastroenterology.

Time-dependent changes in neurokinin3 receptors and tachykinins during adjuvant-induced peripheral inflammation in the rat

D. R. Linden, K. McCarson, V. Seybold, 2000, Neuroscience.

Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis.

D. R. Linden, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion.

Weston R. Whitaker, M. Fischbach, J. Sonnenburg, 2018, Cell host & microbe.

163 Hyperglycemia-Induced Hyperplasia of Interstitial Cells of Cajal (ICC) and ICC Stem Cells (ICC-SC) Is Associated With Accelerated Gastric Emptying in Obese Diabetic LeprDb/Db Mice

B. Rubin, G. Farrugia, J. Szurszewski, 2013 .

Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide

D. R. Linden, V. Seybold, 1999, Pain.

CA1 Neurons Currents in Isolated Rat 2+ and Low-Threshold Ca Differential Sensitivity to Intracellular pH Among High-

G. Somjen, M. Kendrick, G. Farrugia, 2015 .

The earthworms of Minnesota (Oligochaeta: Acanthodrilidae Lumbricidae and Megascolecidae)

J. Reynolds, D. R. Linden, C. Hale, 2002 .

Physiology of Prevertebral Sympathetic Ganglia

J. Szurszewski, D. R. Linden, 2012 .

Production of the gaseous signal molecule hydrogen sulfide in mouse tissues

G. Farrugia, J. Szurszewski, D. R. Linden, 2008, Journal of neurochemistry.

Arachidonic Acid Inhibition of Muscarinic Receptor-Mediated Nitric Oxide Production Occurs at the Level of Calcium Mobilization in Chinese Hamster Ovary Cells

D. R. Linden, E. El-Fakahany, E. El‐Fakahany, 2002, Neurochemical Research.

Spinal neurokin3 receptors facilitate the nociceptive flexor reflex via a pathway involving nitric oxide

D. R. Linden, Yu-ping Jia, V. Seybold, 1999, Pain.

Changes in nitrergic and tachykininergic pathways in rat proximal colon in response to chronic treatment with otilonium bromide

G. Farrugia, J. Szurszewski, D. R. Linden, 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Nociceptin/orphanin FQ binding increases in superficial laminae of the rat spinal cord during persistent peripheral inflammation

D. R. Linden, Yu-ping Jia, V. Seybold, 1998, Neuroscience Letters.

Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis.

D. R. Linden, M. Gershon, K. Sharkey, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Effects of gastrointestinal inflammation on enteroendocrine cells and enteric neural reflex circuits

D. R. Linden, K. Sharkey, G. Mawe, 2006, Autonomic Neuroscience.

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

A. Leiter, G. Farrugia, J. Szurszewski, 2018, Proceedings of the National Academy of Sciences.

Muscularis Propria Macrophages Alter the Proportion of Nitrergic but Not Cholinergic Gastric Myenteric Neurons

G. Farrugia, J. Szurszewski, D. R. Linden, 2019, Cellular and molecular gastroenterology and hepatology.

Altered gut microbiota in female mice with persistent low body weights following removal of post-weaning chronic dietary restriction

Nicholas Chia, Gianrico Farrugia, Jun Chen, 2016, Genome Medicine.

High temporal resolution gastric emptying breath tests in mice

G. Farrugia, J. Szurszewski, D. R. Linden, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons.

D. R. Linden, N. Bunnett, G. Mawe, 2001, European journal of pharmacology.

Synaptic plasticity in myenteric neurons of the guinea‐pig distal colon: presynaptic mechanisms of inflammation‐induced synaptic facilitation

D. R. Linden, K. Sharkey, G. Mawe, 2007, The Journal of physiology.

Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle

G. Farrugia, J. Szurszewski, D. R. Linden, 2014, The Journal of physiology.

High‐fat diet–induced alterations to gut microbiota and gut‐derived lipoteichoic acid contributes to the development of enteric neuropathy

L. Forney, O. Balemba, D. R. Linden, 2020, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Measurement of Gastrointestinal and Colonic Motor Functions in Humans and Animals

M. Camilleri, D. R. Linden, 2016, Cellular and molecular gastroenterology and hepatology.

Getting a Handle on Cholera and the Circuits Controlling Intestinal Motility

D. R. Linden, P. Bertrand, 2010, Front. Neurosci..

Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function.

G. Farrugia, J. Szurszewski, D. R. Linden, 2010, Antioxidants & redox signaling.

Intestinal enteroendocrine cells rely on ryanodine and IP3 calcium store receptors for mechanotransduction

G. Farrugia, D. R. Linden, A. Beyder, 2022, The Journal of physiology.

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

Gianrico Farrugia, Fan Wang, David R Linden, 2017, The Journal of physiology.

Hydrogen Sulfide Selectively Potentiates Central Preganglionic Fast Nicotinic Synaptic Input in Mouse Superior Mesenteric Ganglion

G. Farrugia, J. Szurszewski, D. R. Linden, 2013, The Journal of Neuroscience.

Hydrogen sulfide modulates contractile function in rat jejunum.

G. Farrugia, D. R. Linden, M. Sarr, 2012, The Journal of surgical research.

Desired and side effects of the supplementation with l-glutamine and l-glutathione in enteric glia of diabetic rats.

D. R. Linden, A. R. Trevizan, C. Hermes-Uliana, 2016, Acta histochemica.

Mechanisms of Action of the Gasotransmitter Hydrogen Sulfide in Modulating Contractile Activity of Longitudinal Muscle of Rat Ileum

D. R. Linden, M. Sarr, J. Duenes, 2010, Journal of Gastrointestinal Surgery.

CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice.

G. Farrugia, J. Szurszewski, D. R. Linden, 2010, Gastroenterology.

A gamma variate model that includes stretched exponential is a better fit for gastric emptying data from mice.

Gianrico Farrugia, David R Linden, Simon J Gibbons, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Colitis is associated with a loss of intestinofugal neurons.

D. R. Linden, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Specialized mechanosensory epithelial cells in mouse gut intrinsic tactile sensitivity.

G. Farrugia, M. Grover, D. R. Linden, 2021, Gastroenterology.

A simple automated approach to measure mouse whole gut transit

Gianrico Farrugia, Halil Kacmaz, Alecia Alto, 2020, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Identification of intrinsic primary afferent neurons in mouse jejunum

D. R. Linden, S. Gibbons, A. Beyder, 2020, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Assessment of gastric emptying in non-obese diabetic mice using a [13C]-octanoic acid breath test.

G. Farrugia, J. Szurszewski, D. R. Linden, 2013, Journal of visualized experiments : JoVE.

Key elements of serotonin signaling are altered in IBD and IBS: support for a molecular basis of the irritable bowel syndrome

D. R. Linden, P. Moses, M. Gershon, 2003, American Journal of Gastroenterology.

Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function

Daniel A Dalenberg, M. Camilleri, T. Smyrk, 2017, The American Journal of Gastroenterology.

The transwall gradient across the mouse colonic circular muscle layer is carbon monoxide dependent

G. Farrugia, J. Szurszewski, D. R. Linden, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Gasotransmitters in the gastrointestinal tract.

D. R. Linden, M. Kreis, M. Sarr, 2008, Surgery.

T2049 Hydrogen Sulfide Ameliorates Murine Experimental Colitis Through Specific Effects on Diverse Classes of Infiltrating Immune Cells

G. Farrugia, J. Szurszewski, D. R. Linden, 2010 .

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

J. Camp, G. Farrugia, J. Szurszewski, 2016, Cellular and molecular gastroenterology and hepatology.

Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging

G. Farrugia, M. Kuro-o, D. R. Linden, 2020, Cellular and molecular gastroenterology and hepatology.

Insulin-Like Growth Factor1 Preserves Gastric Pacemaker Cells and Motor Function in Aging via ERK1/2 Activation

D. R. Linden, T. Kellogg, Y. Hayashi, 2023, Cellular and molecular gastroenterology and hepatology.

Altered gut microbiota in female mice with persistent low body weights following removal of post-weaning chronic dietary restriction

G. Farrugia, N. Chia, J. Szurszewski, 2016, Genome Medicine.

Novel promoter and alternate transcription start site of the human serotonin reuptake transporter in intestinal mucosa

D. R. Linden, G. Mawe, S. White, 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function.

Daniel A Dalenberg, M. Camilleri, T. Smyrk, 2017 .

Serotonin signaling in the mucosa of the human colon

M. Crowell, D. R. Linden, M. Coates, 2003 .

Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis.

D. R. Linden, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Hydrogen sulfide signaling in the gastrointestinal tract.

D. R. Linden, 2014, Antioxidants & redox signaling.

Microwave-Based Dielectric Properties as an Electrophysiological Biomarker: Future Perspectives

D. R. Linden, S. Dey, K. Kulkarni, 2023, Electronics.

CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice.

G. Farrugia, J. Szurszewski, D. R. Linden, 2010, Gastroenterology.

Adeno‐associated virus‐9 reverses delayed gastric emptying of solids in diabetic mice

Matthew L. Hillestad, G. Farrugia, M. Grover, 2023, Neurogastroenterology and motility.

Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5.

M. Kendrick, G. Farrugia, J. Szurszewski, 2011, American journal of physiology. Gastrointestinal and liver physiology.

Assessment of gastric emptying in non-obese diabetic mice using a [13C]-octanoic acid breath test.

G. Farrugia, J. Szurszewski, D. R. Linden, 2013, Journal of visualized experiments : JoVE.

A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.

G. Farrugia, D. R. Linden, S. Gibbons, 2015, American journal of physiology. Gastrointestinal and liver physiology.