H. Xiang

发表

Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities.

Chengfeng Bai, Shuangjie Wu, Shengnan Ren, 2021, Bioorganic & medicinal chemistry.

New ligands for copper-catalyzed C–N coupling reactions with aryl halides

H. Xiang, Sheng Jiang, Dong Chen, 2012 .

Hypolipidemic effect of XH601 on hamsters of Hyperlipidemia and its potential mechanism

H. Xiang, Meng Zhao, Shan-shan Wang, 2017, Lipids in Health and Disease.

Design, synthesis and evaluation of 6-aryl-indenoisoquinolone derivatives dual targeting ERα and VEGFR-2 as anti-breast cancer agents.

Q. You, Guoshun Luo, H. Xiang, 2016, European journal of medicinal chemistry.

Evaluating the Potential Bioactivity of a Novel Compound ER1626

H. Xiang, Hongyi Liu, Yanyan Zeng, 2014, PloS one.

Impact of ER520, a candidate of selective estrogen receptor modulators, on in vitro cell growth, migration, invasion, angiogenesis and in vivo tumor xenograft of human breast cancer cells

H. Xiang, Hongyi Liu, Yao Jiang, 2015, Cancer Chemotherapy and Pharmacology.

Design, synthesis, and biological evaluation of novel androst-17β-amide structurally related compounds as dual 5α-reductase inhibitors and androgen receptor antagonists

H. Xiang, Xingchun Gou, Kejing Lao, 2019, Journal of enzyme inhibition and medicinal chemistry.

Targeting of the FOXM1 Oncoprotein by E3 Ligase-Assisted Degradation.

Guoshun Luo, H. Xiang, Xin Lin, 2021, Journal of medicinal chemistry.

Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance.

Guoshun Luo, H. Xiang, Xin Lin, 2020, European journal of medicinal chemistry.

Lipid accumulation inhibitory activities of novel isoxazole-based chenodeoxycholic acids: Design, synthesis and preliminary mechanism study.

Q. You, Guoshun Luo, H. Xiang, 2018, Bioorganic & medicinal chemistry letters.

Lipid reducing activity of novel cholic acid (CA) analogs: Design, synthesis and preliminary mechanism study.

Q. You, Guoshun Luo, H. Xiang, 2018, Bioorganic chemistry.

Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities.

Q. You, H. Xiang, Yi He, 2015, Bioorganic & medicinal chemistry.

Open Access Research

H. Xiang, Yan Zeng, Hong Shen, 2022 .

Structure-guided design and synthesis of isoflavone analogs of GW4064 with potent lipid accumulation inhibitory activities.

Q. You, Guoshun Luo, H. Xiang, 2018, Bioorganic & medicinal chemistry letters.

Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors.

Yanliang Ren, Wei Huang, H. Xiang, 2015, Bioorganic & medicinal chemistry.

Recent advancement in nonsteroidal aromatase inhibitors for treatment of estrogen-dependent breast cancer.

H. Xiang, J. Jiao, Q. Liao, 2010, Current medicinal chemistry.

Synthesis and evaluation of novel thiosemicarbazone and semicarbazone analogs with both anti-proliferative and anti-metastatic activities against triple negative breast cancer.

Chengfeng Bai, Shuangjie Wu, Shengnan Ren, 2021, Bioorganic & medicinal chemistry.

Discovery of potent and highly selective covalent inhibitors of Bruton's tyrosine kinase bearing triazine scaffold.

Shengnan Ren, Guoshun Luo, H. Xiang, 2020, European journal of medicinal chemistry.

Pyrrolo[2,3-b]pyridine derivatives as potent Bruton's tyrosine kinase inhibitors.

Wei Huang, H. Xiang, Yazhou Wang, 2015, Bioorganic & medicinal chemistry.

Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer.

Shuangjie Wu, Shengnan Ren, Guoshun Luo, 2021, European journal of medicinal chemistry.

Design, synthesis, biological evaluation and molecular docking studies of novel 3-aryl-4-anilino-2H-chromen-2-one derivatives targeting ERα as anti-breast cancer agents.

Q. You, Guoshun Luo, H. Xiang, 2017, Bioorganic & medicinal chemistry letters.

Discovery of novel 2H-chromene-3-carbonyl derivatives as selective estrogen receptor degraders (SERDs): Design, synthesis and biological evaluation.

Guoshun Luo, H. Xiang, Xin Lin, 2021, Bioorganic chemistry.

Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator.

Guoshun Luo, H. Xiang, Xin Lin, 2020, European journal of medicinal chemistry.

Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities.

Wei Zhao, H. Xiang, Hong Xiao, 2010, Bioorganic & medicinal chemistry.

Novel 11β-substituted estradiol conjugates: Transition from ERα agonizts to effective PROTAC degraders

Guoshun Luo, H. Xiang, Xin Lin, 2022, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis and biological evaluation of new flavonoid fatty acid esters with anti-adipogenic and enhancing glucose consumption activities.

Wei Zhao, H. Xiang, Yan Zeng, 2011, Bioorganic & medicinal chemistry.

A General and Facile Synthesis of Novel Polysubstituted Quinazolin‐4(3H)‐ones

Q. You, H. Xiang, Yi He, 2013 .

An efficient, practical synthesis of 2-methoxyestradiol

Q. You, H. Xiang, Minhang Xin, 2010, Steroids.

Design, synthesis and biological evaluation of novel 3-substituted 4-anilino-coumarin derivatives as antitumor agents.

Q. You, Guoshun Luo, H. Xiang, 2017, Bioorganic & medicinal chemistry letters.

Novel SERMs based on 3-aryl-4-aryloxy-2H-chromen-2-one skeleton - A possible way to dual ERα/VEGFR-2 ligands for treatment of breast cancer.

Q. You, Guoshun Luo, H. Xiang, 2017, European journal of medicinal chemistry.

Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ERα and VEGFR-2.

Q. You, Guoshun Luo, H. Xiang, 2019, European journal of medicinal chemistry.

A review on steroidal 5α-reductase inhibitors for treatment of benign prostatic hyperplasia.

H. Xiang, J. Sun, L-L Yang, 2011, Current medicinal chemistry.

Discovery of novel steroidal-chalcone hybrids with potent and selective activity against triple-negative breast cancer.

Chengfeng Bai, Guoshun Luo, H. Xiang, 2020, Bioorganic & medicinal chemistry.

Synthesis of Tribolure, the Common Aggregation Pheromone of Four Tribolium Flour Beetles

H. Xiang, W. Tian, Yong‐Ling Shi, 2015 .

Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules.

Guoshun Luo, H. Xiang, Xin Lin, 2019, European journal of medicinal chemistry.

Design and synthesis of benzofuro[3,2-b]pyridin-2(1H)-one derivatives as anti-leukemia agents by inhibiting Btk and PI3Kδ.

Q. You, Guoshun Luo, H. Xiang, 2018, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives as dual 5α-reductase inhibitors and androgen receptor antagonists.

Q. You, H. Xiang, Ying Wang, 2017, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel steroidal imidazoles as dual inhibitors of AR/CYP17 for the treatment of prostate cancer

Q. You, Guoshun Luo, H. Xiang, 2019, Steroids.

Strategies to overcome resistance mutations of Bruton's tyrosine kinase inhibitor ibrutinib.

H. Xiang, Xiang-qian Wang, Linyi Liu, 2018, Future medicinal chemistry.

Synthesis and biological evaluation of 4,6-diaryl-2-pyrimidinamine derivatives as anti-breast cancer agents.

Q. You, H. Xiang, Xinyu Li, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 2,3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ERα and VEGFR-2.

Luyong Zhang, Q. You, H. Xiang, 2014, Bioorganic & medicinal chemistry letters.

Optimization of novel benzofuro[3,2-b]pyridin-2(1H)-one derivatives as dual inhibitors of BTK and PI3Kδ.

H. Xiang, Xinyu Li, Linyi Liu, 2019, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors.

Wei Huang, Wei Huang, H. Xiang, 2015, Bioorganic & medicinal chemistry.

Discovery of thieno[3,2-c]pyridin-4-amines as novel Bruton's tyrosine kinase (BTK) inhibitors.

Wei Huang, Wei Huang, H. Xiang, 2015, Bioorganic & medicinal chemistry.

A new class of 1,3,5-triazine-based selective estrogen receptor degraders (SERDs): Lead optimization, molecular docking and dynamic simulation.

Guoshun Luo, H. Xiang, Liang Sun, 2020, Bioorganic chemistry.

Novel 6-amino-1,3,5-triazine derivatives as potent BTK inhibitors: structure-activity relationship (SAR) analysis and preliminary mechanism investigation.

Shuangjie Wu, Meiqi Zhu, Guoshun Luo, 2022, Bioorganic chemistry.

Design, synthesis and biological evaluation of novel 2-phenyl pyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors.

Q. You, H. Xiang, Yu-Ning Teng, 2019, MedChemComm.

Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo

Guoshun Luo, H. Xiang, Xin Lin, 2020, Acta pharmaceutica Sinica. B.

Microwave-assisted copper- and palladium-catalyzed sonogashira-type coupling of aryl bromides and iodides with trimethylsilylacetylene

Q. You, H. Xiang, Haopeng Sun, 2016 .

A comparison study to investigate the effect of the drug-loading site on its delivery efficacy using double hydrophilic block copolymer-based prodrugs.

H. Xiang, Xufeng Zhou, Hua Wei, 2017, Journal of materials chemistry. B.

Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity.

Shengnan Ren, Guoshun Luo, H. Xiang, 2020, European journal of medicinal chemistry.

Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer.

Chengfeng Bai, Shuangjie Wu, Shengnan Ren, 2021, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel 2-methoxyestradiol analogs as dual selective estrogen receptor modulators (SERMs) and antiangiogenic agents.

Q. You, H. Xiang, Kejing Lao, 2017, European journal of medicinal chemistry.

3, 9-di-O-substituted coumestrols incorporating basic amine side chains act as novel apoptosis inducers with improved pharmacological selectivity.

Guoshun Luo, H. Xiang, Xinyu Li, 2019, Bioorganic chemistry.

Structure-activity relationships of 2, 4-disubstituted pyrimidines as dual ERα/VEGFR-2 ligands with anti-breast cancer activity.

Q. You, Guoshun Luo, H. Xiang, 2018, European journal of medicinal chemistry.

O2-3-Aminopropyl diazeniumdiolates suppress the progression of highly metastatic triple-negative breast cancer by inhibition of microvesicle formation via nitric oxide-based epigenetic regulation.

H. Xiang, Jide Tian, Yihua Zhang, 2018, Chemical science.

Structural optimization of tetrahydroisoquinoline-hydroxamate hybrids as potent dual ERα degraders and HDAC inhibitors.

X. Wang, Meiqi Zhu, Guoshun Luo, 2023, Bioorganic chemistry.

Hypolipidemic effect of XH601 on hamsters of Hyperlipidemia and its potential mechanism

H. Xiang, Meng Zhao, Shan-shan Wang, 2017, Lipids in Health and Disease.