Hai-Bing Zhou

发表

Novel hybrid conjugates with dual estrogen receptor α degradation and histone deacetylase inhibitory activities for breast cancer therapy.

Chenxi Zhao, Chu Tang, Changhao Li, 2021, Bioorganic & medicinal chemistry.

Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.

Jun Wu, Chu Tang, Changhao Li, 2015, Journal of medicinal chemistry.

Establishment of evaluation criteria for the development of high quality ERα-targeted fluorescent probes.

Hai-Bing Zhou, Jian Huang, C. Dong, 2020, The Analyst.

Thiophene Oxidation and Reduction Chemistry

Hai-Bing Zhou, Yuzhi Lu, Z. Dong, 2014 .

Selenophenes: Introducing a New Element into the Core of Non‐Steroidal Estrogen Receptor Ligands

J. Katzenellenbogen, K. Carlson, Junjie Luo, 2017, ChemMedChem.

Triaryl-Substituted Schiff Bases Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor

J. Nwachukwu, S. Srinivasan, J. Katzenellenbogen, 2014, Journal of medicinal chemistry.

Synthesis of N-benzyl-N-phenylthiophene-2-carboxamide analogues as a novel class of enterovirus 71 inhibitors

P. Tien, Hai-Bing Zhou, Shuwen Wu, 2015 .

High-Throughput Screening Assays for Estrogen Receptor by Using Coumestrol, a Natural Fluorescence Compound

Caihua Wang, Changhao Li, Hai-Bing Zhou, 2014, Journal of biomolecular screening.

Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells.

F. Zhang, Caihua Wang, Changhao Li, 2012, Organic & biomolecular chemistry.

Halolactones are potent HIV-1 non-nucleoside reverse transcriptase inhibitors

P. Tien, W. Xie, Hai-Bing Zhou, 2015 .

Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

P. Tien, Hai-Bing Zhou, C. Dong, 2014, Organic & biomolecular chemistry.

Bisperoxovandium (pyridin‐2‐squaramide) targets both PTEN and ERK1/2 to confer neuroprotection

F. Liu, Hai-Bing Zhou, W. Liao, 2017, British journal of pharmacology.

Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins.

Hai-Bing Zhou, Jun Li, Yuzhi Lu, 2016, ACS medicinal chemistry letters.

Recent advances in gossypol derivatives and analogs: a chemistry and biology view.

Hai-Bing Zhou, Jian Huang, C. Dong, 2017, Future medicinal chemistry.

Discovery of oseltamivir-based novel PROTACs as degraders targeting neuraminidase to combat H1N1 influenza virus

Hai-Bing Zhou, C. Dong, Xiaoyu Ma, 2022, Cell insight.

Exploring the PROTAC degron candidates: OBHSA with different side chains as novel selective estrogen receptor degraders (SERDs).

Yuan Xiao, Zhiye Hu, Hai-Bing Zhou, 2019, European journal of medicinal chemistry.

Estrogen receptor sensing in living cells by a high affinity turn-on fluorescent probe

Wentao Ning, Hai-Bing Zhou, C. Dong, 2018, Sensors and Actuators B: Chemical.

Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.

K. Hong, Hai-Bing Zhou, Liang Yang, 2021, European journal of medicinal chemistry.

Rational design of ERα targeting hypoxia turn-on fluorescent probes with antiproliferative activity for breast cancer.

F. Zhou, Zhiye Hu, Hai-Bing Zhou, 2020, Chemical communications.

Novel class of 7-Oxabicyclo[2.2.1]heptene sulfonamides with long alkyl chains displaying improved estrogen receptor α degradation activity.

Yuan Xiao, Chenxi Zhao, Wentao Ning, 2019, European journal of medicinal chemistry.

Estrogen receptor β-targeted hypoxia-responsive near-infrared fluorescence probes for prostate cancer study.

Hai-Bing Zhou, C. Dong, Qiuyu Meng, 2022, European journal of medicinal chemistry.

The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage

Zhi‐Feng Zhang, Hai-Bing Zhou, Xin Han, 2019, Drug design, development and therapy.

Discovery of Novel Bicyclic Phenylselenyl-Containing Hybrids: An Orally Bioavailable, Potential, and Multiacting Class of Estrogen Receptor Modulators against Endocrine-Resistant Breast Cancer.

Zhiye Hu, Hai-Bing Zhou, Jian Huang, 2022, Journal of medicinal chemistry.

The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia.

Li Liu, Yongchang Wei, F. Zhou, 2019, Free radical biology & medicine.

Highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids from chiral imines of trifluoropyruvate.

Hai-Bing Zhou, Xingang Zhang, Chun-Yang He, 2010, Chemical communications.

Curcumin inhibits BACE1 expression through the interaction between ERβ and NFκB signaling pathway in SH-SY5Y cells

Hai-Bing Zhou, Jian Huang, Nan Zheng, 2019, Molecular and Cellular Biochemistry.

Synthesis and structure-activity relationship study of arylsulfonamides as novel potent H5N1 inhibitors.

Hai-Bing Zhou, C. Dong, Shuwen Wu, 2018, European journal of medicinal chemistry.

Furan-carboxamide derivatives as novel inhibitors of lethal H5N1 influenza A viruses

Hai-Bing Zhou, C. Dong, Shuwen Wu, 2017 .

Fluorine-18 labeling and biodistribution studies on peroxisome proliferator-activated receptor-gamma ligands: potential positron emission tomography imaging agents.

Ephraim E. Parent, C. Dence, M. Welch, 2009, Nuclear medicine and biology.

Construction of benzofuranone library via a metal-free, one-pot intermolecular condensation, and their application as efficient estrogen receptor β modulators.

Wentao Ning, Zhiye Hu, Hai-Bing Zhou, 2019, Chemical communications.

Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy.

Junjie Luo, Yuan Xiao, Zhiye Hu, 2017, MedChemComm.

Design, synthesis and biological evaluation of novel estrogen-derived steroid metal complexes.

Juan Tang, Caihua Wang, Changhao Li, 2013, Bioorganic & medicinal chemistry letters.

Bromination from the macroscopic level to the tracer radiochemical level: (76)Br radiolabeling of aromatic compounds via electrophilic substitution.

Jason S. Lewis, M. Welch, J. Katzenellenbogen, 2009, Bioconjugate chemistry.

Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells

Jun Wu, Caihua Wang, Hai-Bing Zhou, 2017, Neurochemical Research.

Corrigendum: NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

B. Katzenellenbogen, A. Joachimiak, J. Nowak, 2008 .

Concise Synthesis of Chiral N-Benzyl-α,α-Diarylprolinols through Shi Asymmetric Epoxidation

Hai-Bing Zhou, J. Weng, Jie Li, 2014 .

Estrogen Receptor β-Targeted Near-Infrared Inherently Fluorescent Probe: A Potent Tool for Estrogen Receptor β Research.

Hai-Bing Zhou, C. Dong, Qiuyu Meng, 2021, ACS sensors.

Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study.

Qiuhan Zhang, T. Shu, Hai-Bing Zhou, 2020, European journal of medicinal chemistry.

Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.

P. Tien, Hai-Bing Zhou, C. Dong, 2016, Journal of medicinal chemistry.

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.

B. Katzenellenbogen, A. Joachimiak, J. Katzenellenbogen, 2007, Journal of medicinal chemistry.

HMDO-promoted peptide and protein synthesis in ionic liquids.

Hai-Bing Zhou, Yao-Liang Sun, G. Qiu, 2013, The Journal of organic chemistry.

Applications of Chiral Squaramides: From Asymmetric Organocatalysis to Biologically Active Compounds.

Hai-Bing Zhou, C. Dong, Xin Han, 2016, Chemical record.

Identification of a novel binding inhibitor that blocks the interaction between hSCARB2 and VP1 of enterovirus 71

Hai-Bing Zhou, Shuwen Wu, Bao-jie Lu, 2022, Cell insight.

Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

J. Baell, Junjie Luo, A. Hofmann, 2016, Parasites & Vectors.

Tunable Bifunctional Phosphine–Squaramide Promoted Morita–Baylis–Hillman Reaction of N-Alkyl Isatins with Acrylates

Hai-Bing Zhou, C. Dong, G. Qiu, 2015 .

Isocyanides as Influenza A Virus Subtype H5N1 Wild‐Type M2 Channel Inhibitors

Constantinos G. Neochoritis, A. Dömling, Hai-Bing Zhou, 2015, ChemMedChem.

A New Pathway for Phthalazine Derivatives via Metal‐Free Cyclization of ortho‐Alkynylphenyl Ketones and Hydrazine

Hai-Bing Zhou, C. Dong, Z. Liao, 2014 .

Design, synthesis and structure of new chiral squaric acid monoaminoalcohols and diaminoalcohols and their use as catalysts in asymmetric reduction of ketones and diketones ☆

A. Chan, Hai-Bing Zhou, Ji Zhang, 2001 .

Chiral squaric prolinols: a new type of ligand for the asymmetric reduction of prochiral ketones by borane

A. Chan, Hai-Bing Zhou, Ji Zhang, 2001 .

Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction.

Zhiye Hu, Hai-Bing Zhou, C. Dong, 2018, Organic and biomolecular chemistry.

A novel C3-symmetric prolinol-squaramide catalyst for the asymmetric reduction of ketones by borane

Hai-Bing Zhou, C. Dong, C. Min, 2011 .

One-step pathway to selenoisobenzofuran-1(3H)-imine derivatives through highly selective selenocyclization of olefinic amides with benzeneselenyl chloride.

Hai-Bing Zhou, C. Dong, Xiwang Li, 2018, Organic & biomolecular chemistry.

C3‐Symmetric Cinchonine‐Squaramide‐Catalyzed Asymmetric Chlorolactonization of Styrene‐Type Carboxylic Acids with 1,3‐Dichloro‐5,5‐dimethylhydantoin: An Efficient Method to Chiral Isochroman‐1‐ones

Hai-Bing Zhou, C. Dong, Xin Han, 2014 .

C3‐Symmetrical Cinchonine‐Squaramide as New Highly Efficient, and Recyclable Organocatalyst for Enantioselective Michael Addition

Hai-Bing Zhou, C. Dong, C. Min, 2011 .

One-pot to fused pyrazoles by a double cyclization of o-alkynylaldehydes with ketones and hydrazine under metal-free condition

B. Liu, Hai-Bing Zhou, C. Dong, 2014 .

Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters

Hai-Bing Zhou, Linhui Zhai, Zixing Deng, 2011 .

Thiophene-core estrogen receptor ligands having superagonist activity.

J. Nwachukwu, S. Srinivasan, J. Katzenellenbogen, 2013, Journal of medicinal chemistry.

Recyclable BINOL–quinine–squaramide as a highly efficient organocatalyst for α-amination of 1,3-dicarbonyl compounds and α-cyanoacetates

Hai-Bing Zhou, C. Dong, Bin Liu, 2015 .

Design, Synthesis and Structure of New Chiral Squaric Acid Monoaminoalcohols and Diaminoalcohols and Their Use as Catalysts in Asymmetric Reduction of Ketones and Diketones.

A. Chan, Hai-Bing Zhou, Ji Zhang, 2002 .

N-Substituted Amides as Chiral Ligands for Catalytic Asymmetric Reactions

Hai-Bing Zhou, Ji Zhang, R. Xie, 2002 .

Chiral monoaminoalcohols and diaminoalcohols of squaric acid: new catalysts for the asymmetric reduction of ketones by borane☆

A. Chan, Hai-Bing Zhou, R. Xie, 2001 .

ChemInform Abstract: Chiral Squaric Prolinols: A New Type of Ligand for the Asymmetric Reduction of Prochiral Ketones by Borane.

A. Chan, Hai-Bing Zhou, Ji Zhang, 2002 .

Highly enantioselective Michael addition of 1,3-dicarbonyl compounds to nitroalkenes catalyzed by designer chiral BINOL–quinine–squaramide: efficient access to optically active nitro-alkanes and their isoxazole derivatives

B. Liu, Hai-Bing Zhou, C. Dong, 2013 .

Regioselective and enantioselective synthesis of seven-membered ring cyclic arylguanidine and urea derivatives

Hai-Bing Zhou, H. Alper, 2004 .

An expedient approach to highly enantioenriched cyclic nitrones mediated by robust and recoverable C3-symmetric cinchonine-squaramide catalysts

Hai-Bing Zhou, C. Dong, C. Min, 2012 .

Chiral osmium complexes with sterically bulky Schiff-base ligands. Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA.

C. Che, Hai-Bing Zhou, Zhongyuan Zhou, 2005, Inorganic chemistry.

Dendritic ruthenium porphyrins: a new class of highly selective catalysts for alkene epoxidation and cyclopropanation.

C. Che, Hai-Bing Zhou, Jie‐Sheng Huang, 2002, Chemistry.

NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

B. Katzenellenbogen, J. Nowak, J. Katzenellenbogen, 2008, Nature chemical biology.

Chiral squaramide as multiple H-bond donor organocatalysts for the asymmetric Michael addition of 1,3-dicarbonyl compounds to nitroolefins

Hai-Bing Zhou, C. Dong, G. Qiu, 2012 .

A Novel C3-Symmetric Prolinol-Squaramide Catalyst for the Asymmetric Reduction of Ketones by Borane.

Hai-Bing Zhou, C. Dong, C. Min, 2012 .

Novel bifunctional chiral squaramide-amine catalysts for highly enantioselective addition of mono- and diketones to nitroalkenes

Hai-Bing Zhou, C. Dong, Z. Dong, 2011 .

Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.

J. Nwachukwu, S. Srinivasan, Valerie Cavett, 2012, Organic & biomolecular chemistry.

Novel rhodium-catalyzed reaction of thiazolidine derivatives with carbodiimides.

Hai-Bing Zhou, C. Dong, H. Alper, 2004, Chemistry.

Synthesis and structure-activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy.

Chenxi Zhao, Chu Tang, Changhao Li, 2016, Bioorganic & medicinal chemistry.

A new tribridged imidazolium cyclophane

Hai-Bing Zhou, Jia-Ming Yan, R. Xie, 2000 .

Synthesis and curing of a novel amino-containing phthalonitrile derivative

Hai-Bing Zhou, Yan Tang, K. Zeng, 2007 .

Synthesis of seven-membered ring diazepin-2-ones via palladium-catalyzed highly regioselective cyclization of 2-vinylpyrrolidines with aryl isocyanates.

Hai-Bing Zhou, H. Alper, 2003, The Journal of organic chemistry.

Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors.

Hai-Bing Zhou, C. Dong, Ke Lan, 2022, Bioorganic chemistry.

Bicyclo[2.2.2]octanes: close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators.

J. Katzenellenbogen, Hai-Bing Zhou, M. Collins, 2007, Bioorganic & medicinal chemistry letters.

Three-dimensional oxabicycloheptene sulfonate targets the homologous recombination and repair programmes through estrogen receptor α antagonism.

Jun Wu, Hai-Bing Zhou, Jian Huang, 2020, Cancer letters.

Anticancer or carcinogenic? The role of estrogen receptor β in breast cancer progression.

Hai-Bing Zhou, C. Dong, Qiuyu Meng, 2023, Pharmacology & therapeutics.

Imaging progesterone receptor in breast tumors: synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of tanaproget.

Christopher G Mayne, J. Katzenellenbogen, K. Carlson, 2010, Journal of medicinal chemistry.

Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity.

F. Stossi, B. Katzenellenbogen, J. Katzenellenbogen, 2009, Bioorganic & medicinal chemistry letters.

Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands.

F. Stossi, B. Katzenellenbogen, A. Joachimiak, 2007, Chemistry & biology.

Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader.

Z. Deng, Jun Wu, K. Hong, 2019, Pharmacological research.

A high-affinity subtype-selective fluorescent probe for estrogen receptor β imaging in living cells.

Chu Tang, Wentao Ning, Zhiye Hu, 2018, Chemical communications.

Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy.

Junjie Luo, Chu Tang, Wentao Ning, 2017, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer.

Wentao Ning, Zhiye Hu, Hai-Bing Zhou, 2020, European journal of medicinal chemistry.

A novel HDAC6 inhibitor exerts an anti‐cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer

Chu Tang, Hai-Bing Zhou, Jian Huang, 2018, European journal of pharmacology.

Antiviral PROTACs: Opportunity borne with challenge

Hai-Bing Zhou, C. Dong, Ke Lan, 2023, Cell insight.

Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.

J. Nwachukwu, Valerie Cavett, J. Katzenellenbogen, 2012, Journal of medicinal chemistry.

Predictive features of ligand‐specific signaling through the estrogen receptor

O. Elemento, J. Nwachukwu, S. Srinivasan, 2016, Molecular systems biology.

Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: estrogen antagonists of unusual structure.

F. Stossi, B. Katzenellenbogen, J. Katzenellenbogen, 2005, Journal of medicinal chemistry.

Development of Selective Estrogen Receptor Modulator (SERM)‐Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7‐Oxabicyclo[2.2.1]hept‐5‐ene Scaffold Core Ligands

J. Nwachukwu, S. Srinivasan, Valerie Cavett, 2012, ChemMedChem.

Design, Synthesis and Biological Evaluation of Pyrano[2,3-b]-naphthoquinone Derivatives as Acetylcholinesterase Inhibitors

Zhiye Hu, Hai-Bing Zhou, C. Dong, 2020, Chinese Journal of Organic Chemistry.

Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer.

Chu Tang, Wentao Ning, Zhiye Hu, 2018, Journal of medicinal chemistry.

Full Antagonism of the Estrogen Receptor without a Prototypical Ligand Side Chain

J. Frasor, B. Katzenellenbogen, J. Nwachukwu, 2016, Nature Chemical Biology.

Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp).

Hai-Bing Zhou, C. Dong, Shuwen Wu, 2022, Journal of medicinal chemistry.

Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non-racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts.

P. Tien, Hai-Bing Zhou, Shuwen Wu, 2013, Organic & biomolecular chemistry.

Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus.

Hai-Bing Zhou, C. Dong, Shuwen Wu, 2019, MedChemComm.

Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer

Hai-Bing Zhou, C. Dong, Baohua Xie, 2023, Acta pharmaceutica Sinica. B.

Curcumin inhibits BACE1 expression through the interaction between ERβ and NFκB signaling pathway in SH-SY5Y cells

Hai-Bing Zhou, Jian Huang, Nan Zheng, 2019, Molecular and Cellular Biochemistry.

Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

J. Frasor, B. Katzenellenbogen, J. Nwachukwu, 2017, Nature chemical biology.

Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer.

Chu Tang, Wentao Ning, Zhiye Hu, 2018, Journal of medicinal chemistry.

Rational design and optimization of acylthioureas as novel potent influenza virus non-nucleoside polymerase inhibitors.

Yihe Wu, Hai-Bing Zhou, C. Dong, 2023, European journal of medicinal chemistry.