P. Hergenrother

Erich A. Lidstone, B. Cunningham, P. Hergenrother, 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation.

P. Hergenrother, K. Putt, 2004, Analytical biochemistry.

An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors.

P. Hergenrother, K. Putt, 2004, Analytical biochemistry.

Going on offense against the gram-negative defense

P. Hergenrother, Bryon S. Drown, 2018, Proceedings of the National Academy of Sciences.

Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations.

P. Hergenrother, Riley L. Svec, 2019, Angewandte Chemie.

Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations

P. Hergenrother, Riley L. Svec, 2019, Angewandte Chemie.

Monitoring Poly(ADP-ribosyl)glycohydrolase Activity with a Continuous Fluorescent Substrate.

I. Ahel, P. Hergenrother, T. Shirai, 2018, Cell chemical biology.

Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums.

P. Hergenrother, Myung-ryul Lee, Stephen E. Motika, 2020, ACS infectious diseases.

Altering substrate specificity of phosphatidylcholine-preferring phospholipase C of Bacillus cereus by random mutagenesis of the headgroup binding site.

P. Hergenrother, Stephen F Martin, Stephen F. Martin, 2003, Biochemistry.

Catalytic cycle of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus. Solvent viscosity, deuterium isotope effects, and proton inventory studies.

P. Hergenrother, S. F. Martín, 1999, Biochemistry.

Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Jun O. Liu, T. Shapiro, P. Hergenrother, 2009, Journal of medicinal chemistry.

Derivatives of Procaspase-Activating Compound 1 (PAC-1) and Anticancer Activities

P. Hergenrother, H. Roth, 2016 .

Synthesis and anticancer activity of all known (-)-agelastatin alkaloids.

P. Hergenrother, D. Siegel, M. Movassaghi, 2013, The Journal of organic chemistry.

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.

P. Hergenrother, T. Tuccinardi, H. Lee, 2017, Journal of agricultural and food chemistry.

Oxygen Starvation Unmasks a Killer.

P. Hergenrother, Riley L. Svec, 2018, Cell chemical biology.

Porous photonic crystal external cavity laser biosensor.

B. Cunningham, P. Hergenrother, Qinglan Huang, 2016, Applied physics letters.

Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death

Rui Huang, P. Hergenrother, D. J. Shapiro, 2018, Cell Death & Differentiation.

Synthesis of dimeric ADP-ribose and its structure with human poly(ADP-ribose) glycohydrolase.

I. Ahel, P. Hergenrother, A. Ariza, 2015, Journal of the American Chemical Society.

A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor.

H. Ciolino, G. C. Yeh, B. Leslie, 2006, Carcinogenesis.

Therapeutics , Targets , and Chemical Biology An NQO 1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP 1-Induced Programmed Necrosis

Elizabeth I. Parkinson, Jinming Gao, Longshan Li, 2012 .

Characterization of erythromycin analogs by collisional activated dissociation and infrared multiphoton dissociation in a quadrupole ion trap

J. Brodbelt, P. Hergenrother, M. Crowe, 2002, Journal of the American Society for Mass Spectrometry.

Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy

Elizabeth I. Parkinson, J. Francis, Matthew W. Boudreau, 2021, Neoplasia.

Synthesis of bridged oxafenestranes from pleuromutilin.

R. Hicklin, P. Hergenrother, Tania L López Silva, 2014, Angewandte Chemie.

The identification and characterization of novel antibacterial compounds via target-based and whole cell screening approaches

S. Silverman, P. Hergenrother, M. Burke, 2011 .

Toxinantitoxin (TA) systems are prevalent and transcribed in clinical isolates of Pseudomonas aeruginosa and methicillinresistant Staphylococcus aureus

Robert M. DiFazio, P. Hergenrother, R. DiFazio, 2011 .

A continuous fluorometric assay for the assessment of MazF ribonuclease activity.

P. Hergenrother, N. R. Wang, Nora R. Wang, 2007, Analytical biochemistry.

The Compound 13‐D Selectively Induces Apoptosis in White Blood Cancers versus Other Cancer Cell Types

Robin S. Dothager, P. Hergenrother, K. Putt, 2006, Chembiochem : a European journal of chemical biology.

Determination of the kinetic parameters for phospholipase C (Bacillus cereus) on different phospholipid substrates using a chromogenic assay based on the quantitation of inorganic phosphate.

P. Hergenrother, S. F. Martín, Stephen F. Martin, 1997, Analytical biochemistry.

Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest.

Robin S. Dothager, B. Leslie, P. Hergenrother, 2005, Journal of the American Chemical Society.

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

D. Kreisel, S. Bornstein, M. Gütschow, 2021, Nature Communications.

Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response

E. Nelson, P. Hergenrother, Xiaobin Zheng, 2014, Oncotarget.

Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins

Y. Xi, J. Ju, P. Hergenrother, 2011, Journal of immunotherapy.

Identification of the Cellular Targets of Bioactive Small Organic Molecules Using Affinity Reagents

B. Leslie, P. Hergenrother, 2008 .

An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli

P. Hergenrother, Zhong Li, Emily J. Geddes, 2021, Nature Protocols.

Small molecule ligands for bulged RNA secondary structures.

P. Hergenrother, S. T. Meyer, 2009, Organic letters.

Deoxystreptamine dimers bind to RNA hairpin loops.

P. Hergenrother, J. Thomas, Xianjun Liu, 2004, Journal of the American Chemical Society.

Porous photonic crystal external cavity laser biosensor for drug screening

B. Cunningham, P. Hergenrother, Qinglan Huang, 2016, 2016 IEEE SENSORS.

Increased poly(ADP-ribose) polymerase activity during porcine hemorrhagic shock is transient and predictive of mortality.

G. Beilman, P. Hergenrother, D. Skarda, 2007, Resuscitation.

Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria.

P. Hergenrother, Kristen A Muñoz, 2021, Accounts of chemical research.

Using peptidic inhibitors to systematically probe the S1' site of caspase-3 and caspase-7.

A. Sharma, P. Hergenrother, David R. Goode, 2005, Organic letters.

Chromogenic assay for phospholipase C from Bacillus cereus.

P. Hergenrother, M. Spaller, S. F. Martín, 1995, Analytical biochemistry.

Computational discovery of dynobactin antibiotics

P. Hergenrother, Kristen A Muñoz, 2022, Nature Microbiology.

An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections

Angela M. Zaino, D. Caridha, P. Hergenrother, 2022, ACS central science.

Natural products: Taming reactive benzynes.

P. Hergenrother, Sarah Z Tasker, 2017, Nature chemistry.

Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species

Elizabeth I. Parkinson, J. Francis, T. Rosol, 2017, Investigational New Drugs.

Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies

M. Nicholas, T. Tarasow, T. Fan, 2015, British Journal of Cancer.

Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria

Elizabeth I. Parkinson, P. Hergenrother, H. Lee, 2015, Nature Communications.

Predictive compound accumulation rules yield a broad-spectrum antibiotic

Michelle F. Richter, Paul J. Hergenrother, P. Hergenrother, 2017, Nature.

Targeting RNA with small molecules.

Paul J Hergenrother, P. Hergenrother, J. Thomas, 2008, Chemical reviews.

DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action.

Paul J Hergenrother, P. Hergenrother, R. Palchaudhuri, 2007, Current opinion in biotechnology.

Total synthesis, stereochemical assignment, and biological activity of all known (-)-trigonoliimines.

P. Hergenrother, M. Movassaghi, Sunkyu Han, 2013, The Journal of organic chemistry.

Synthesis of (±)-actinophyllic acid and analogs: applications of cascade reactions and diverted total synthesis.

Elizabeth I. Parkinson, Bruce K. Hua, P. Hergenrother, 2013, Journal of the American Chemical Society.

Natural products as starting points for the synthesis of complex and diverse compounds.

Paul J Hergenrother, P. Hergenrother, Karen C Morrison, 2014, Natural product reports.

The complex role of the triphenylmethyl motif in anticancer compounds.

Paul J Hergenrother, P. Hergenrother, R. Palchaudhuri, 2008, Journal of the American Chemical Society.

Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells.

Paul J Hergenrother, P. Hergenrother, R. Palchaudhuri, 2008, Bioorganic & medicinal chemistry letters.

Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene.

P. Hergenrother, D. Olson, D. Sarlah, 2018, Journal of the American Chemical Society.

Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3.

P. Hergenrother, Quinn P. Peterson, D. C. Hsu, 2009, Journal of medicinal chemistry.

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

E. Giovannetti, G. Peters, P. Hergenrother, 2011, Journal of medicinal chemistry.

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds.

P. Hergenrother, T. Tuccinardi, A. Martinelli, 2013, Organic & biomolecular chemistry.

An abiotic strategy for the enantioselective synthesis of erythromycin B.

A. Hodgson, P. Hergenrother, S. Martin, 2003, Angewandte Chemie.

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products.

R. Hicklin, P. Hergenrother, R. W. Huigens, 2013, Nature chemistry.

A colorimetric substrate for poly(ADP-ribose) polymerase-1, VPARP, and tankyrase-1.

Robin S. Dothager, P. Hergenrother, A. Nottbohm, 2007, Angewandte Chemie.

Deoxynyboquinones as NQO1-Activated Cancer Therapeutics.

Paul J Hergenrother, Elizabeth I. Parkinson, P. Hergenrother, 2015, Accounts of chemical research.

A Phosphonate Natural Product Made by Pantoea ananatis is Necessary and Sufficient for the Hallmark Lesions of Onion Center Rot

W. Metcalf, P. Hergenrother, Lucia Furiassi, 2021, mBio.

The challenge of converting Gram‐positive‐only compounds into broad‐spectrum antibiotics

P. Hergenrother, M. Richter, 2019, Annals of the New York Academy of Sciences.

Glucose conjugation for the specific targeting and treatment of cancer.

Paul J Hergenrother, P. Hergenrother, Emilia C Calvaresi, 2013, Chemical science.

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition.

P. Hergenrother, Quinn P. Peterson, David R. Goode, 2009, Journal of molecular biology.

Size-specific ligands for RNA hairpin loops.

P. Hergenrother, J. Thomas, Xianjun Liu, 2005, Journal of the American Chemical Society.

Efficient Synthesis of Enantiopure β-Amino-γ-Keto Acids from l-Homoserine

A. Sharma, P. Hergenrother, 2003 .

Biochemical and thermodynamic characterization of compounds that bind to RNA hairpin loops: toward an understanding of selectivity.

P. Hergenrother, J. Thomas, Xianjun Liu, 2006, Biochemistry.

The choline binding site of phospholipase C (Bacillus cereus): insights into substrate specificity.

P. Hergenrother, B. Follows, S. F. Martín, 2000, Biochemistry.

Mitigation of SARS-CoV-2 transmission at a large public university

Sandeep Puthanveetil Satheesan, Brian R. Brauer, Zachary J. Weiner, 2021, Nature Communications.

Efficient Synthesis of Enantiopure β‐Amino‐γ‐Keto Acids from L‐Homoserine.

A. Sharma, P. Hergenrother, 2003 .

Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential.

Matthew W. Boudreau, P. Hergenrother, Jessie Peh, 2019, ACS chemical biology.

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

P. Pandolfi, M. Fraga, M. Esteller, 2019, Acta Neuropathologica.

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.

R. Peterson, T. Fan, P. Hergenrother, 2015, Cell reports.

Efficient NQO1 substrates are potent and selective anticancer agents.

Elizabeth I. Parkinson, Megan A. Cismesia, P. Hergenrother, 2013, ACS chemical biology.

Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques.

Christopher J Huck, P. Hergenrother, D. Sarlah, 2021, Journal of the American Chemical Society.

Bacterial death comes full circle: targeting plasmid replication in drug-resistant bacteria.

P. Hergenrother, Johna C B Denap, 2005, Organic & biomolecular chemistry.

Iron salts perturb biofilm formation and disrupt existing biofilms of Pseudomonas aeruginosa.

Paul J Hergenrother, P. Hergenrother, D. J. Musk, 2005, Chemistry & biology.

N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.

P. Hergenrother, R. Palchaudhuri, Jonathan A Stefely, 2010, Journal of medicinal chemistry.

A novel class of zinc-binding inhibitors for the phosphatidylcholine-preferring phospholipase C from Bacillus cereus.

P. Hergenrother, B. Follows, S. F. Martín, 2000, The Journal of organic chemistry.

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

Evijola Llabani, Paul J. Hergenrother, R. Hicklin, 2019, Nature Chemistry.

Identification of the cellular targets of bioactive small organic molecules using affinity reagents.

B. Leslie, P. Hergenrother, 2008, Chemical Society reviews.

Phosphatidylcholine-Preferring Phospholipase C from B. cereus. Function, Structure, and Mechanism

P. Hergenrother, S. Martin, 2000 .

Transcript profiling and RNA interference as tools to identify small molecule mechanisms and therapeutic potential.

P. Hergenrother, R. Palchaudhuri, 2011, ACS chemical biology.

Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities.

P. Hergenrother, H. Roth, 2016, Current medicinal chemistry.

Chromogenic assay for phospholipase D from Streptomyces chromofuscus: Application to the evaluation of substrate analogs

P. Hergenrother, S. Martin, M. K. Haas, 1997, Lipids.

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

Lisa J. Schlein, M. Podell, G. Riggins, 2017, Oncotarget.

Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism

P. Hergenrother, R. Palchaudhuri, Mirth T. Hoyt, 2011, Investigational New Drugs.

Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture.

T. Fan, P. Hergenrother, Riley L. Svec, 2022, ACS chemical biology.

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.

P. Hergenrother, T. Tuccinardi, A. Martinelli, 2015, RSC advances.

Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity

T. Fan, P. Hergenrother, L. Borst, 2014, Journal of the American Chemical Society.

Whole cell microtubule analysis by flow cytometry.

P. Hergenrother, K. Morrison, 2012, Analytical biochemistry.

Toxin–antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococci

P. Hergenrother, Elizabeth M. Moritz, 2007, Proceedings of the National Academy of Sciences.

Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

Martin D. Burke, Fadi G. Alnaji, Paul J. Hergenrother, 2020, bioRxiv.

Differential effects of procaspase-3 activating compounds in the induction of cancer cell death.

A. Palmer, T. Fan, P. Hergenrother, 2012, Molecular pharmaceutics.

Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1).

P. Hergenrother, Rachel C. Botham, H. Roth, 2012, ACS combinatorial science.

Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

S. Gabelli, A. Leung, P. Hergenrother, 2019, Scientific Reports.

Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

S. Gabelli, A. Leung, P. Hergenrother, 2019, Scientific Reports.

Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death.

P. Hergenrother, R. Palchaudhuri, Joseph S. Bair, 2010, Journal of the American Chemical Society.

Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids.

P. Hergenrother, Justin Kim, M. Movassaghi, 2013, Chemical science.

Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation.

Matthew W. Boudreau, P. Hergenrother, Jessie Peh, 2018, Cell chemical biology.

Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression

T. Ha, M. Lee, S. Myong, 2017, bioRxiv.

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy

H. Chan, P. Hergenrother, S. Zimmerman, 2016, ChemMedChem.

Determination of the substrate specificity of the phospholipase D from Streptomyces chromofuscus via an inorganic phosphate quantitation assay.

P. Hergenrother, S. F. Martín, R. DeBlanc, 2000, Analytical biochemistry.

Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

G. Riggins, T. Fan, P. Hergenrother, 2018, ACS chemical biology.

The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas

T. Fan, P. Hergenrother, K. Wycislo, 2016, Molecular Cancer Therapeutics.

A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth That Enhances Proteasome-dependent Degradation of Estrogen Receptor α*

R. Schiff, E. Wilson, S. Nordeen, 2010, The Journal of Biological Chemistry.

Dual Targeting of the Warburg Effect with a Glucose‐Conjugated Lactate Dehydrogenase Inhibitor

P. Hergenrother, T. Tuccinardi, A. Martinelli, 2013, Chembiochem : a European journal of chemical biology.

Poly(ADP-ribose) makes a date with death.

P. Hergenrother, J. Heeres, 2007, Current opinion in chemical biology.

The relationship between aminoglycosides' RNA binding proclivity and their antiplasmid effect on an IncB plasmid.

P. Hergenrother, J. Thomas, M. Wong, 2005, Biochemistry.

Cyclopropylacetylene: [Cyclopropane, ethynyl-]

P. Hergenrother, S. Martin, E. Corley, 2000 .

Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine.

P. Hergenrother, Bryon S. Drown, Alfredo Garcia, 2016, Organic letters.

Re-engineering natural products to engage new biological targets.

Stephen E Motika, Paul J Hergenrother, P. Hergenrother, 2020, Natural product reports.

Preparation of Structurally Diverse Compounds from the Natural Product Lycorine.

P. Hergenrother, A. E. Cowfer, Sarah Z Tasker, 2018, Organic letters.

Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy.

T. Fan, P. Hergenrother, M. Berry, 2022, Journal of the American Chemical Society.

Exposing Plasmids as the Achilles' Heel of Drug-resistant Bacteria This Review Comes from a Themed Issue on Next-generation Therapeutics Edited Inhibition of Plasmid Conjugation Inhibition of Plasmid Replication by Mimicking Plasmid Incompatibility Toxin–antitoxin Systems

P. Hergenrother, Julia J. Williams, Floyd Romesberg, 2022 .

Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase

M. Dunstan, I. Ahel, P. Hergenrother, 2012, Nature Communications.

A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors.

Paul J Hergenrother, Leo L Chan, Brian T Cunningham, 2008, ACS chemical biology.

Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge

E. Tajkhorshid, W. Metcalf, P. Hergenrother, 2021, Chemical science.

Rationalizing generation of broad spectrum antibiotics with the addition of a primary amine

E. Tajkhorshid, W. Metcalf, P. Hergenrother, 2021 .

Role of internal loop dynamics in antibiotic permeability of outer membrane porins

E. Tajkhorshid, D. Shukla, W. Metcalf, 2022, Proceedings of the National Academy of Sciences.

Investigation of gating in outer membrane porins provides new perspectives on antibiotic resistance mechanisms

E. Tajkhorshid, D. Shukla, W. Metcalf, 2021, bioRxiv.

Reaction: Broad-Spectrum Antibiotics, a Call for Chemists

P. Hergenrother, M. Richter, 2017 .

Identification of a Novel Protein Synthesis Inhibitor Active against Gram‐Positive Bacteria

P. Hergenrother, I. Im, Nisha Y. Patel, 2012, Chembiochem : a European journal of chemical biology.

Detection of Protein–Small Molecule Binding Using a Self-Referencing External Cavity Laser Biosensor

Meng Zhang, Brian T. Cunningham, Paul J. Hergenrother, 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Small-Molecule Microarrays: Covalent Attachment and Screening of Alcohol-Containing Small Molecules on Glass Slides

Stuart L. Schreiber, Paul J. Hergenrother, S. Schreiber, 2000 .

Txe, an endoribonuclease of the enterococcal Axe–Txe toxin–antitoxin system, cleaves mRNA and inhibits protein synthesis

P. Hergenrother, Emily A. Billings, Julia J. Williams, 2011, Microbiology.

(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition

I. Ahel, P. Hergenrother, T. Shirai, 2018, Cell chemical biology.

Enzymatic synthesis of a modified phospholipid and its evaluation as a substrate for B. cereus phospholipase C.

P. Hergenrother, S. F. Martín, 1998, Bioorganic & medicinal chemistry letters.

Synthesis of Fusidic Acid Derivatives Yields a Potent Antibiotic with an Improved Resistance Profile.

P. Hergenrother, H. Lee, G. Lau, 2021, ACS infectious diseases.

Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor

Meng Zhang, Brian T. Cunningham, Paul J. Hergenrother, 2014, EMBC.

Identifying modulators of protein-protein interactions using photonic crystal biosensors.

Paul J Hergenrother, Erich A. Lidstone, Brian T Cunningham, 2009, Journal of the American Chemical Society.

Runaway ROS as a Selective Anticancer Strategy

Elizabeth I. Parkinson, P. Hergenrother, 2011, ChemMedChem.

Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death

Rui Huang, P. Hergenrother, Mara R. Livezey, 2018, Cell Death & Differentiation.

Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics.

T. Fan, P. Hergenrother, Rachel C. Botham, 2015, Journal of medicinal chemistry.

Chelated iron sources are inhibitors of Pseudomonas aeruginosa biofilms and distribute efficiently in an in vitro model of drug delivery to the human lung

P. Hergenrother, D. J. Musk, Dinty J. Musk, 2008, Journal of applied microbiology.

Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor

A. Baranger, W. Chan, H. Tsoi, 2014, Journal of the American Chemical Society.

Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG).

P. Hergenrother, K. Partlow, A. Nottbohm, 2012, ACS chemical biology.

Molecular medicine and cancer.

P. Sadler, P. Hergenrother, H. Wallace, 2015, Chemical Society reviews.

Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer.

Matthew W. Boudreau, T. Fan, P. Hergenrother, 2022, Journal of medicinal chemistry.

Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response

E. Nelson, P. Hergenrother, Xiaobin Zheng, 2016, Oncotarget.

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model

E. Roy, T. Fan, P. Hergenrother, 2023, Journal for ImmunoTherapy of Cancer.

Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers

Lisa J. Schlein, C. Eberhart, T. Fan, 2019, Front. Oncol..

Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens

P. Hergenrother, H. Lee, G. Lau, 2019, Nature Microbiology.

Total synthesis and cytoprotective properties of dykellic acid.

P. Hergenrother, C. A. Quinn, C. Thompson, 2009, Journal of medicinal chemistry.

Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in overcoming targeted therapy dosage challenges.

V. Bafna, T. Graeber, P. N. Rao, 2021, Cancer discovery.

General base catalysis by the phosphatidylcholine-preferring phospholipase C from Bacillus cereus: the role of Glu4 and Asp55.

P. Hergenrother, S. F. Martín, 1998, Biochemistry.

Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146.

P. Hergenrother, M. Spaller, S. F. Martín, 1996, Biochemistry.

The Promises and Pitfalls of Small‐Molecule Inhibition of Poly(ADP‐Ribose) Glycohydrolase (PARG)

P. Hergenrother, A. Nottbohm, 2006 .

Obtaining and screening compound collections: a user's guide and a call to chemists.

Paul J Hergenrother, P. Hergenrother, 2006, Current opinion in chemical biology.

Combating drug-resistant bacteria: small molecule mimics of plasmid incompatibility as antiplasmid compounds.

P. Hergenrother, J. Thomas, D. J. Musk, 2004, Journal of the American Chemical Society.

Phenylcinnamides as novel antimitotic agents.

B. Leslie, P. Hergenrother, Tran Nguyen, 2010, Journal of medicinal chemistry.

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

J. Katzenellenbogen, K. Carlson, Xiaozhuo Chen, 2015, ChemMedChem.

Glucose Conjugation for the Specific Targeting and Treatment of Cancer

P. Hergenrother, Emilia C. Calvaresi, 2013 .

Light activation of Staphylococcus aureus toxin YoeBSa1 reveals guanosine-specific endoribonuclease activity.

P. Hergenrother, Amy Larson, 2014, Biochemistry.

Identification of Novel Synthetic Toll-like Receptor 2 Agonists by High Throughput Screening*

R. Tapping, P. Hergenrother, Y. Guan, 2010, The Journal of Biological Chemistry.

A Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch.

P. Hergenrother, H. Lee, G. Lau, 2020, Journal of the American Chemical Society.

Bacterial Death Comes Full Circle: Targeting Plasmid Replication in Drug-Resistant Bacteria

P. Hergenrother, Johna C B Denap, 2005 .

High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies.

P. Hergenrother, J. Heeres, 2011, Chemical Society reviews.

Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression

Liqian Ma, Hong Chen, F. Végran, 2023, bioRxiv.

A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates

Brian T. Cunningham, Erich A. Lidstone, Paul J. Hergenrother, 2009, JALA.

Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

S. Gabelli, A. Leung, P. Hergenrother, 2019, Scientific Reports.

Crystal structure of HsNUDT16 in complex with diADPR (soaked)

S. Gabelli, A. Leung, P. Hergenrother, 2019 .

ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-ribosyl-L-arginine

I. Ahel, P. Hergenrother, T. Shirai, 2018 .

Synthesis of complex and diverse compounds through ring distortion of abietic acid.

R. Hicklin, P. Hergenrother, Ryan J. Rafferty, 2014, Angewandte Chemie.

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition.

P. Hergenrother, Quinn P. Peterson, David R. Goode, 2009, Journal of molecular biology.

Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death.

Elizabeth I. Parkinson, D. Panigrahy, P. Hergenrother, 2017, ACS chemical biology.

Small molecule ligands for bulged RNA secondary structures.

P. Hergenrother, S. T. Meyer, 2009, Organic Letters.

A New Small Molecule Inhibitor of Estrogen Receptor α Binding to Estrogen Response Elements Blocks Estrogen-dependent Growth of Cancer Cells*

Jingwei Cheng, E. Wilson, A. Nardulli, 2008, Journal of Biological Chemistry.

Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3 – Activating Compound

T. Fan, P. Hergenrother, D. C. Hsu, 2010 .

Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors

B. Agianian, Aslamuzzaman Kazi, P. Hergenrother, 2023, Cancer research communications.

The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma

Matthew W. Boudreau, T. Tarasow, P. Hergenrother, 2023, Melanoma research.

Natural products: Taming reactive benzynes.

P. Hergenrother, Sarah Z Tasker, 2017, Nature chemistry.

Exposing plasmids as the Achilles' heel of drug-resistant bacteria.

P. Hergenrother, Julia J. Williams, 2008, Current opinion in chemical biology.

Synthesis of (±)-actinophyllic acid and analogs: applications of cascade reactions and diverted total synthesis.

Elizabeth I. Parkinson, Bruce K. Hua, P. Hergenrother, 2013, Journal of the American Chemical Society.

Using permeation guidelines to design new antibiotics—A PASsagE into Pseudomonas aeruginosa

P. Hergenrother, Brett N. Cain, 2024, Clinical and translational medicine.

A new type of antibiotic targets a drug-resistant bacterium

P. Hergenrother, Morgan K. Gugger, 2024, Nature.

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

E. Giovannetti, G. Peters, P. Hergenrother, 2011, Journal of medicinal chemistry.

Detection of Protein–Small Molecule Binding Using a Self-Referencing External Cavity Laser Biosensor

Meng Zhang, B. Cunningham, P. Hergenrother, 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.