S. Kłossowski

发表

Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C.

T. Cierpicki, C. Carpenter, R. Sorenson, 2016, Bioorganic & medicinal chemistry.

Model studies on the first enzyme-catalyzed Ugi reaction.

S. Kłossowski, R. Ostaszewski, Barbara Wiraszka, 2013, Organic letters.

Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma

D. Nowis, J. Gołąb, P. Gaj, 2015, Oncotarget.

SK053 triggers tumor cells apoptosis by oxidative stress-mediated endoplasmic reticulum stress.

J. Gołąb, S. Kłossowski, M. Kujawa, 2015, Biochemical pharmacology.

Studies toward novel peptidomimetic inhibitors of thioredoxin-thioredoxin reductase system.

J. Gołąb, S. Kłossowski, M. Firczuk, 2012, Journal of medicinal chemistry.

Enzymatic Ugi Reaction with Amines and Cyclic Imines.

S. Kłossowski, Anna Żądło-Dobrowolska, Dominik Koszelewski, 2016, Chemistry.

Synthesis of novel, peptidic kinase inhibitors with cytostatic/cytotoxic activity.

W. Szymański, S. Kłossowski, J. Malejczyk, 2014, Bioorganic & medicinal chemistry.

Studies towards enzymatic kinetic resolutions of 1,3-diol peptidomimetics obtained via the Ugi reaction

S. Kłossowski, S. Szymkuć, R. Ostaszewski, 2013 .

Chemoenzymatic synthesis and application of a new, easily chiral auxiliary for the synthesis of peptidomimetics via an Ugi reaction

S. Kłossowski, R. Ostaszewski, A. Brodzka, 2014 .

Enzymatic Synergism in the Synthesis of β-Keto Esters

S. Kłossowski, Dominik Koszelewski, R. Ostaszewski, 2015 .

Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules

T. Cierpicki, J. Grembecka, S. Kłossowski, 2017, MedChemComm.

Menin regulates the serine biosynthetic pathway in Ewing sarcoma

Dafydd G. Thomas, Ho-Joon Lee, T. Cierpicki, 2018, The Journal of pathology.

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations.

T. Cierpicki, J. Grembecka, S. Kłossowski, 2020, Blood.

Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.

T. Cierpicki, J. Grembecka, S. Kłossowski, 2018, Journal of medicinal chemistry.

Adenanthin targets proteins involved in the regulation of disulphide bonds.

D. Nowis, J. Gołąb, Han-Dong Sun, 2014, Biochemical pharmacology.

Pharmacologic Inhibition of the Menin–MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma

T. Cierpicki, J. Grembecka, S. Kłossowski, 2017, Molecular Cancer Therapeutics.

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.

O. Abdel-Wahab, Y. Dou, T. Cierpicki, 2019, The Journal of clinical investigation.

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML with activating FLT3 mutations.

T. Cierpicki, J. Grembecka, S. Kłossowski, 2020, Blood.

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

Y. Dou, T. Cierpicki, J. Grembecka, 2021, Nature Communications.