C. Dong

发表

Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.

Jun Wu, Chu Tang, Changhao Li, 2015, Journal of medicinal chemistry.

Establishment of evaluation criteria for the development of high quality ERα-targeted fluorescent probes.

Hai-Bing Zhou, Jian Huang, C. Dong, 2020, The Analyst.

Selenophenes: Introducing a New Element into the Core of Non‐Steroidal Estrogen Receptor Ligands

J. Katzenellenbogen, K. Carlson, Junjie Luo, 2017, ChemMedChem.

Triaryl-Substituted Schiff Bases Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor

J. Nwachukwu, S. Srinivasan, J. Katzenellenbogen, 2014, Journal of medicinal chemistry.

Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells.

F. Zhang, Caihua Wang, Changhao Li, 2012, Organic & biomolecular chemistry.

A facile one-pot multi-component synthesis of novel adamantine substituted imidazo[1,2-a]pyridine derivatives: identification and structure–activity relationship study of their anti-HIV-1 activity

P. Tien, C. Dong, Shuwen Wu, 2016 .

Halolactones are potent HIV-1 non-nucleoside reverse transcriptase inhibitors

P. Tien, W. Xie, Hai-Bing Zhou, 2015 .

Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

P. Tien, Hai-Bing Zhou, C. Dong, 2014, Organic & biomolecular chemistry.

Enantioselective cyclocarbonylation of 2-vinylanilines to six-membered ring lactams

C. Dong, H. Alper, 2004 .

Recent advances in gossypol derivatives and analogs: a chemistry and biology view.

Hai-Bing Zhou, Jian Huang, C. Dong, 2017, Future medicinal chemistry.

Discovery of oseltamivir-based novel PROTACs as degraders targeting neuraminidase to combat H1N1 influenza virus

Hai-Bing Zhou, C. Dong, Xiaoyu Ma, 2022, Cell insight.

Exploring the PROTAC degron candidates: OBHSA with different side chains as novel selective estrogen receptor degraders (SERDs).

Yuan Xiao, Zhiye Hu, Hai-Bing Zhou, 2019, European journal of medicinal chemistry.

Estrogen receptor sensing in living cells by a high affinity turn-on fluorescent probe

Wentao Ning, Hai-Bing Zhou, C. Dong, 2018, Sensors and Actuators B: Chemical.

Rational design of ERα targeting hypoxia turn-on fluorescent probes with antiproliferative activity for breast cancer.

F. Zhou, Zhiye Hu, Hai-Bing Zhou, 2020, Chemical communications.

Novel class of 7-Oxabicyclo[2.2.1]heptene sulfonamides with long alkyl chains displaying improved estrogen receptor α degradation activity.

Yuan Xiao, Chenxi Zhao, Wentao Ning, 2019, European journal of medicinal chemistry.

Estrogen receptor β-targeted hypoxia-responsive near-infrared fluorescence probes for prostate cancer study.

Hai-Bing Zhou, C. Dong, Qiuyu Meng, 2022, European journal of medicinal chemistry.

(1R,2R)‐1,2‐Diphenyl‐1,2‐bis(8‐quinolinesulfonylamino)ethylenediamine–acetone (1/1)

C. Dong, Zuolong Yu, Jun‐Long Zhang, 2000 .

Discovery of Novel Bicyclic Phenylselenyl-Containing Hybrids: An Orally Bioavailable, Potential, and Multiacting Class of Estrogen Receptor Modulators against Endocrine-Resistant Breast Cancer.

Zhiye Hu, Hai-Bing Zhou, Jian Huang, 2022, Journal of medicinal chemistry.

Synthesis and structure-activity relationship study of arylsulfonamides as novel potent H5N1 inhibitors.

Hai-Bing Zhou, C. Dong, Shuwen Wu, 2018, European journal of medicinal chemistry.

Furan-carboxamide derivatives as novel inhibitors of lethal H5N1 influenza A viruses

Hai-Bing Zhou, C. Dong, Shuwen Wu, 2017 .

Construction of benzofuranone library via a metal-free, one-pot intermolecular condensation, and their application as efficient estrogen receptor β modulators.

Wentao Ning, Zhiye Hu, Hai-Bing Zhou, 2019, Chemical communications.

Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy.

Junjie Luo, Yuan Xiao, Zhiye Hu, 2017, MedChemComm.

Estrogen Receptor β-Targeted Near-Infrared Inherently Fluorescent Probe: A Potent Tool for Estrogen Receptor β Research.

Hai-Bing Zhou, C. Dong, Qiuyu Meng, 2021, ACS sensors.

Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.

P. Tien, Hai-Bing Zhou, C. Dong, 2016, Journal of medicinal chemistry.

Applications of Chiral Squaramides: From Asymmetric Organocatalysis to Biologically Active Compounds.

Hai-Bing Zhou, C. Dong, Xin Han, 2016, Chemical record.

Tunable Bifunctional Phosphine–Squaramide Promoted Morita–Baylis–Hillman Reaction of N-Alkyl Isatins with Acrylates

Hai-Bing Zhou, C. Dong, G. Qiu, 2015 .

Efficient synthesis of fused pyrazoles via simple cyclization of o-alkynylchalcones with hydrazine

C. Dong, Ying Li, 2015 .

A New Pathway for Phthalazine Derivatives via Metal‐Free Cyclization of ortho‐Alkynylphenyl Ketones and Hydrazine

Hai-Bing Zhou, C. Dong, Z. Liao, 2014 .

Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction.

Zhiye Hu, Hai-Bing Zhou, C. Dong, 2018, Organic and biomolecular chemistry.

A novel C3-symmetric prolinol-squaramide catalyst for the asymmetric reduction of ketones by borane

Hai-Bing Zhou, C. Dong, C. Min, 2011 .

One-step pathway to selenoisobenzofuran-1(3H)-imine derivatives through highly selective selenocyclization of olefinic amides with benzeneselenyl chloride.

Hai-Bing Zhou, C. Dong, Xiwang Li, 2018, Organic & biomolecular chemistry.

Catalytic asymmetric cyclocarbonylation of o-isopropenylphenols: enantioselective synthesis of six-membered ring lactones.

C. Dong, H. Alper, 2004, The Journal of organic chemistry.

C3‐Symmetric Cinchonine‐Squaramide‐Catalyzed Asymmetric Chlorolactonization of Styrene‐Type Carboxylic Acids with 1,3‐Dichloro‐5,5‐dimethylhydantoin: An Efficient Method to Chiral Isochroman‐1‐ones

Hai-Bing Zhou, C. Dong, Xin Han, 2014 .

BINOL–quinine–squaramides as efficient organocatalysts for the asymmetric Michael addition of 2-hydroxy-1,4-naphthoquinone to nitroalkenes

B. Liu, C. Dong, E. Zhou, 2014 .

C3-Symmetric cinchonine-squaramide as a recyclable efficient organocatalyst for tandem Michael addition–cyclisation of malononitrile and nitrovinylphenols

C. Dong, Shi Tang, Z. Dong, 2016 .

C3‐Symmetrical Cinchonine‐Squaramide as New Highly Efficient, and Recyclable Organocatalyst for Enantioselective Michael Addition

Hai-Bing Zhou, C. Dong, C. Min, 2011 .

One-pot to fused pyrazoles by a double cyclization of o-alkynylaldehydes with ketones and hydrazine under metal-free condition

B. Liu, Hai-Bing Zhou, C. Dong, 2014 .

C2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates

C. Dong, Zhi-Yong Wang, Shi Tang, 2015 .

Recyclable BINOL–quinine–squaramide as a highly efficient organocatalyst for α-amination of 1,3-dicarbonyl compounds and α-cyanoacetates

Hai-Bing Zhou, C. Dong, Bin Liu, 2015 .

Highly enantioselective Michael addition of 1,3-dicarbonyl compounds to nitroalkenes catalyzed by designer chiral BINOL–quinine–squaramide: efficient access to optically active nitro-alkanes and their isoxazole derivatives

B. Liu, Hai-Bing Zhou, C. Dong, 2013 .

Enhanced efficiency of recyclable C3-symmetric cinchonine-squaramides in the asymmetric Friedel–Crafts reaction of indoles with alkyl trifluoropyruvate

C. Dong, B. Liu, Haibin Zhou, 2012 .

An expedient approach to highly enantioenriched cyclic nitrones mediated by robust and recoverable C3-symmetric cinchonine-squaramide catalysts

Hai-Bing Zhou, C. Dong, C. Min, 2012 .

Facile synthesis of 1,3,4-benzotriazepines and 1-arylamide-1H-indazoles via palladium-catalyzed cyclization of aryl isocyanates and aryl hydrazones under microwave irradiation.

C. Dong, W. Su, X. Mou, 2010, Organic & biomolecular chemistry.

Chiral squaramide as multiple H-bond donor organocatalysts for the asymmetric Michael addition of 1,3-dicarbonyl compounds to nitroolefins

Hai-Bing Zhou, C. Dong, G. Qiu, 2012 .

A Novel C3-Symmetric Prolinol-Squaramide Catalyst for the Asymmetric Reduction of Ketones by Borane.

Hai-Bing Zhou, C. Dong, C. Min, 2012 .

Novel bifunctional chiral squaramide-amine catalysts for highly enantioselective addition of mono- and diketones to nitroalkenes

Hai-Bing Zhou, C. Dong, Z. Dong, 2011 .

Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.

J. Nwachukwu, S. Srinivasan, Valerie Cavett, 2012, Organic & biomolecular chemistry.

Novel rhodium-catalyzed reaction of thiazolidine derivatives with carbodiimides.

Hai-Bing Zhou, C. Dong, H. Alper, 2004, Chemistry.

Highly regioselective synthesis of tetrahydro-2H-1,3-thiazin-2-ones via rhodium-catalyzed carbonylation of N-alkylisothiazolidines.

C. Dong, H. Alper, 2004, Organic letters.

Synthesis and structure-activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy.

Chenxi Zhao, Chu Tang, Changhao Li, 2016, Bioorganic & medicinal chemistry.

Heterogeneous asymmetric addition of diethylzinc to aromatic aldehydes catalyzed by Ti(IV)/imine bridged poly(R)-binaphthol

A. Chan, C. Dong, Zuolong Yu, 2000 .

Design and synthesis of novel C2-symmetric chiral shift reagents derived from squaramide and their recognition of anions and chiral carboxylate anions

C. Dong, Yuzhi Lu, Jin Zhang, 2014 .

Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors.

Hai-Bing Zhou, C. Dong, Ke Lan, 2022, Bioorganic chemistry.

Anticancer or carcinogenic? The role of estrogen receptor β in breast cancer progression.

Hai-Bing Zhou, C. Dong, Qiuyu Meng, 2023, Pharmacology & therapeutics.

A high-affinity subtype-selective fluorescent probe for estrogen receptor β imaging in living cells.

Chu Tang, Wentao Ning, Zhiye Hu, 2018, Chemical communications.

Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy.

Junjie Luo, Chu Tang, Wentao Ning, 2017, Bioorganic & medicinal chemistry.

Development of Highly Efficient Estrogen Receptor β-Targeted Near-Infrared Fluorescence Probes Triggered by Endogenous Hydrogen Peroxide for Diagnostic Imaging of Prostate Cancer

C. Dong, Baohua Xie, Xiaofei Deng, 2023, Molecules.

Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer.

Wentao Ning, Zhiye Hu, Hai-Bing Zhou, 2020, European journal of medicinal chemistry.

Antiviral PROTACs: Opportunity borne with challenge

Hai-Bing Zhou, C. Dong, Ke Lan, 2023, Cell insight.

Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.

J. Nwachukwu, Valerie Cavett, J. Katzenellenbogen, 2012, Journal of medicinal chemistry.

Predictive features of ligand‐specific signaling through the estrogen receptor

O. Elemento, J. Nwachukwu, S. Srinivasan, 2016, Molecular systems biology.

Development of Selective Estrogen Receptor Modulator (SERM)‐Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7‐Oxabicyclo[2.2.1]hept‐5‐ene Scaffold Core Ligands

J. Nwachukwu, S. Srinivasan, Valerie Cavett, 2012, ChemMedChem.

Design, Synthesis and Biological Evaluation of Pyrano[2,3-b]-naphthoquinone Derivatives as Acetylcholinesterase Inhibitors

Zhiye Hu, Hai-Bing Zhou, C. Dong, 2020, Chinese Journal of Organic Chemistry.

Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer.

Chu Tang, Wentao Ning, Zhiye Hu, 2018, Journal of medicinal chemistry.

Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp).

Hai-Bing Zhou, C. Dong, Shuwen Wu, 2022, Journal of medicinal chemistry.

CeCl3 promoted asymmetric cycloaddition of isocyanates with 2-vinylaziridines

C. Dong, H. Alper, 2004 .

CeCl3-Promoted Asymmetric Cycloaddition of Isocyanates with 2-Vinylaziridines.

C. Dong, H. Alper, 2004 .

Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer.

Chun-Chi Chen, Lilan Xin, Jian Huang, 2023, European journal of medicinal chemistry.

Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus.

Hai-Bing Zhou, C. Dong, Shuwen Wu, 2019, MedChemComm.

Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer

Hai-Bing Zhou, C. Dong, Baohua Xie, 2023, Acta pharmaceutica Sinica. B.

Discovery of estrogen receptor α targeting caged hypoxia-responsive PROTACs with an inherent bicyclic skeleton for breast cancer treatment.

Lilan Xin, C. Dong, Baohua Xie, 2023, Bioorganic chemistry.

Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer.

Wentao Ning, Zhiye Hu, Lilan Xin, 2023, Journal of medicinal chemistry.

Discovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-Resistant Breast Cancer In Vitro and In Vivo.

Zhiye Hu, Jian Huang, C. Dong, 2023, Journal of medicinal chemistry.

Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer.

Chu Tang, Wentao Ning, Zhiye Hu, 2018, Journal of medicinal chemistry.

Discovery of Novel ERα and Aromatase Dual-Targeting PROTAC Degraders to Overcome Endocrine-Resistant Breast Cancer.

Lilan Xin, C. Dong, Baohua Xie, 2024, Journal of medicinal chemistry.

Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways.

Lilan Xin, C. Dong, Xiaoyu Ma, 2024, Journal of medicinal chemistry.

Rational design and optimization of acylthioureas as novel potent influenza virus non-nucleoside polymerase inhibitors.

Yihe Wu, Hai-Bing Zhou, C. Dong, 2023, European journal of medicinal chemistry.

Novel Hsp90-Targeting PROTACs: Enhanced synergy with cisplatin in combination therapy of cervical cancer.

Lilan Xin, C. Dong, Jinsen Liang, 2024, European journal of medicinal chemistry.