D. Poirier

发表

Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.

C. Doillon, Xiaoqiang Wang, C. Gérard, 2015, Journal of molecular cell biology.

Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase.

D. Poirier, Sheng-Xiang Lin, W. Qiu, 2005, Journal of medicinal chemistry.

Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2016, Bioorganic & medicinal chemistry letters.

Chemical synthesis, characterisation and biological evaluation of lactonic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

D. Poirier, S. Farhane, M. Fournier, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

A New Nonestrogenic Steroidal Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer Tumor Growth Induced by Estrone

D. Poirier, J. Roy, D. Ayan, 2012, Molecular Cancer Therapeutics.

Therapeutic Discovery A New Nonestrogenic Steroidal Inhibitor of 17 b-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer TumorGrowth Induced by Estrone

D. Poirier, J. Roy, D. Ayan, 2012 .

Contribution to the development of inhibitors of 17β-hydroxysteroid dehydrogenase types 1 and 7: Key tools for studying and treating estrogen-dependent diseases

D. Poirier, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Convergent stereoselective and efficient synthesis of furanic-steroid derivatives

D. Poirier, S. Farhane, M. Fournier, 2011 .

Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker

D. Poirier, Marie Bérubé, Florian Delagoutte, 2010, Molecules.

Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy.

D. Poirier, Sheng-Xiang Lin, M. Mazumdar, 2009, The Biochemical journal.

Relative involvement of three 17β-hydroxysteroid dehydrogenases (types 1, 7 and 12) in the formation of estradiol in various breast cancer cell lines using selective inhibitors

C. Rancourt, D. Poirier, Yannick Laplante, 2009, Molecular and Cellular Endocrinology.

Improved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17β-hydroxysteroid dehydrogenase type 1

D. Poirier, Marie Bérubé, 2009, Journal of enzyme inhibition and medicinal chemistry.

Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol–adenosine hybrids as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

D. Poirier, Marie Bérubé, 2009 .

Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone.

D. Poirier, M. Fournier, C. Cadot, 2008, Bioorganic & medicinal chemistry.

Chemical Synthesis of (S)‐Spiro(estradiol‐17,2′‐[1,4]oxazinan)‐6′‐one Derivatives Bearing Two Levels of Molecular Diversity

D. Poirier, J. Roy, François Rouillard, 2008 .

Design and synthesis of bisubstrate inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: overview and perspectives.

D. Poirier, M. Mazumdar, D. Fournier, 2008, European journal of medicinal chemistry.

Chemical synthesis and in vitro biological evaluation of a phosphorylated bisubstrate inhibitor of type 3 17β-hydroxysteroid dehydrogenase

D. Poirier, Marie Bérubé, 2007 .

17α-Alkyl- or 17α-substituted benzyl-17β-estradiols: A new family of estrone-sulfatase inhibitors

D. Poirier, R. Boivin, 1998 .

Diversity-Oriented Synthesis of Spiro- and Fused Azacycles from Ketone Molecular Templates

D. Poirier, R. Maltais, 2012 .

A 6β-(thiaheptanamide) derivative of estradiol as inhibitor of 17β-hydroxysteroid dehydrogenase type 1

D. Poirier, P. Dionne, S. Auger, 1998, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis and biological activities of thioether derivatives related to the antiestrogens tamoxifen and ICI 164384

D. Poirier, F. Labrie, S. Auger, 1995, The Journal of Steroid Biochemistry and Molecular Biology.

Derivatives of ethynylestradiol with oxygenated 17 alpha-alkyl side chain: synthesis and biological activity.

C. Labrie, D. Poirier, F. Labrie, 1990, Journal of steroid biochemistry.

17β-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in addition to Estradiol Production

D. Poirier, Sheng-Xiang Lin, M. Mazumdar, 2010 .

Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress‐related response induced by pro‐apoptotic aminosteroid RM‐133

D. Poirier, S. Gobeil, J. Lehoux, 2018, Pharmacological research.

Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine

S. Mader, V. Giguère, D. Poirier, 2019, The Journal of Steroid Biochemistry and Molecular Biology.

Comparison between hippocampus-synthesized and circulation-derived sex steroids in the hippocampus.

H. Mukai, S. Kawato, D. Poirier, 2009, Endocrinology.

Inhibitors of cytochrome P450 (CYP) 1B1.

D. Poirier, Raphaël Dutour, 2017, European journal of medicinal chemistry.

Characteristics of human types 1, 2 and 3 17β-hydroxysteroid dehydrogenase activities: Oxidation/reduction and inhibition

D. Poirier, F. Labrie, V. Luu‐The, 1995, The Journal of Steroid Biochemistry and Molecular Biology.

Inhibitors of type 1 17β-hydroxysteroid dehydrogenase with reduced estrogenic activity: Modifications of the positions 3 and 6 of estradiol

D. Poirier, R. Boivin, M. Tremblay, 2005, Journal of enzyme inhibition and medicinal chemistry.

Estrone and estradiol C-16 derivatives as inhibitors of type 1 17β-hydroxysteroid dehydrogenase

D. Poirier, Sheng-Xiang Lin, Ho-Jin Chang, 2006, Molecular and Cellular Endocrinology.

Synthesis of simplified hybrid inhibitors of type 1 17beta-hydroxysteroid dehydrogenase via cross-metathesis and sonogashira coupling Reactions.

D. Poirier, Marie Bérubé, 2004, Organic letters.

Androsterone 3α-Ether-3β-Substituted and Androsterone 3β-Substituted Derivatives as Inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase: Chemical Synthesis and Structure−Activity Relationship

D. Poirier, F. Labrie, V. Luu‐The, 2005 .

Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry.

D. Poirier, R. Maltais, V. Luu‐The, 2002, Journal of medicinal chemistry.

Solid-phase synthesis of phenolic steroids: Towards combinatorial libraries of estradiol derivatives

D. Poirier, M. Tremblay, 1999 .

Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines

C. Doillon, D. Poirier, J. Roy, 2012, Anti-cancer drugs.

Turning a Quinoline-based Steroidal Anticancer Agent into Fluorescent Dye for its Tracking by Cell Imaging.

D. Poirier, J. Roy, R. Maltais, 2021, ACS medicinal chemistry letters.

Two androsterone derivatives as inhibitors of androgen biosynthesis.

D. Poirier, M. Simard, L. Kenmogne, 2012, Acta crystallographica. Section C, Crystal structure communications.

8‐BuS‐ATP derivatives as specific NTPDase1 inhibitors

J. Brosseau, B. Künzli, É. Rousseau, 2013, British journal of pharmacology.

Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2

K. Cianflone, J. Fradette, D. Poirier, 2015, Molecular and Cellular Endocrinology.

Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-Ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity, and Selectivity.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2018, Journal of medicinal chemistry.

Discovery of a non-estrogenic irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 from 3-substituted-16β-(m-carbamoylbenzyl)-estradiol derivatives.

P. Lagüe, D. Poirier, D. Ayan, 2014, Journal of medicinal chemistry.

Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX.

A. Marette, D. Poirier, R. Maltais, 2019, The Journal of organic chemistry.

Solid-phase synthesis of model libraries of 3 α17β-dihydroxy-16α-(aminoethyl-N-substituted)-5α-androstanes for the development of steroidal therapeutic agents

D. Poirier, F. Labrie, R. Maltais, 2005, Molecular Diversity.

Expert Opinion on Therapeutic Patents

D. Poirier, R. Maltais, L. Ciobanu, 1999 .

Structure-Based Design and Synthesis of New Estrane-Pyridine Derivatives as Cytochrome P450 (CYP) 1B1 Inhibitors.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2017, ACS medicinal chemistry letters.

New efficient pathway for the synthesis of 3-aminoestrone

D. Poirier, L. Provencher, Ioana Radu, 2002 .

Multiple actions of synthetic ‘progestins’ on the growth of ZR-75-1 human breast cancer cells: Anin vitro model for the simultaneous assay of androgen, progestin, estrogen, and glucocorticoid agonistic and antagonistic activities of steroids

D. Poirier, F. Labrie, R. Poulin, 2005, Breast Cancer Research and Treatment.

13C nuclear magnetic resonance study of 17α-substituted estradiols

D. Poirier, P. Dionne, 1995, Steroids.

Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen.

D. Poirier, J. Roy, R. Maltais, 2019, Bioorganic & medicinal chemistry letters.

Impact of androstane A- and D-ring inversion on 17β-hydroxysteroid dehydrogenase type 3 inhibitory activity, androgenic effect and metabolic stability.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2017, Bioorganic & medicinal chemistry.

Synthesis, NMR Characterization, and Antileukemic Activity of N-Nonanoylpiperazinyl-5α-Androstane-3α,17β-Diol A-Ring Derivatives

D. Poirier, J. Roy, R. Maltais, 2020, Magnetochemistry.

Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133

D. Poirier, J. Roy, R. Maltais, 2014, Steroids.

Proliferative effect of androst-4-ene-3,17-dione and its metabolites in the androgen-sensitive LNCaP cell line

D. Poirier, Yannick Laplante, 2008, Steroids.

Identification of fused 16β,17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors.

P. Lagüe, D. Poirier, R. Maltais, 2015, European journal of medicinal chemistry.

17α-Alkan (or alkyn) amide derivatives of estradiol as inhibitors of steroid-sulfatase activity

D. Poirier, F. Labrie, R. Boivin, 1999, Steroids.

New diethylsilylacetylenic linker for parallel solid-phase synthesis of libraries of hydroxy acetylenic steroid derivatives with improved metabolic stability.

D. Poirier, R. Maltais, Amélie Talbot, 2012, ACS combinatorial science.

Antiestrogenic properties of keoxifene,trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells

D. Poirier, F. Labrie, Y. Mérand, 1989, Breast Cancer Research and Treatment.

Androgen and glucocorticoid receptor-mediated inhibition of cell proliferation by medroxyprogesterone acetate in ZR-75-1 human breast cancer cells

D. Poirier, F. Labrie, R. Poulin, 1989, Breast Cancer Research and Treatment.

3-Hydroxy-19-nor-17α-pregna-1,3,5(10)-triene-21,17β-carbolactone as inhibitor of 17β-hydroxysteroid dehydrogenase type 2

D. Poirier, V. Luu‐The, S. Auger, 1994 .

Parallel solid-phase synthesis of a model library of 7alpha-alkylamide estradiol derivatives as potential estrogen receptor antagonists.

D. Poirier, M. Tremblay, J. Simard, 1999, Bioorganic & medicinal chemistry letters.

Synthesis of 16-[carbamoyl(bromomethyl)alkyl]estradiol: a potential dual-action inhibitor designed to blockade estrogen action and biosynthesis

D. Poirier, M. Tremblay, 1996 .

Steroid sulfatase inhibition success and limitation in breast cancer clinical assays: An underlying mechanism

D. Poirier, Sheng-Xiang Lin, Xiaoye Sang, 2018, The Journal of Steroid Biochemistry and Molecular Biology.

Chemical synthesis of fluorinated and iodinated 17β-HSD3 inhibitors and evaluation for imaging prostate cancer tumors and tissue biodistribution.

J. Rousseau, R. Lecomte, D. Poirier, 2022, Bioorganic chemistry.

A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models

D. Poirier, J. Roy, R. Maltais, 2021, Cancers.

Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments

D. Poirier, J. Roy, D. Ayan, 2017, The Journal of Steroid Biochemistry and Molecular Biology.

Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity

P. Lagüe, D. Poirier, R. Maltais, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

Interactions between Estrogens, Androgens, Progestins, and Glucocorticoids in ZR‐75‐1 Human Breast Cancer Cells

M. Dumont, J. Simard, C. Labrie, 1990, Annals of the New York Academy of Sciences.

Characterization of desoxymethyltestosterone main urinary metabolite produced from cultures of human fresh hepatocytes

D. Poirier, C. Ayotte, J. Gauthier, 2012, Steroids.

Antisulfatase, Osteogenic, and Anticancer Activities of Steroid Sulfatase Inhibitor EO-33 in Mice.

D. Poirier, J. Roy, D. Ayan, 2019, Journal of medicinal chemistry.

Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases

D. Poirier, J. Roy, B. T. Ngatcha, 2013, Molecules.

Solid-phase chemical synthesis and in vitro biological evaluation of novel 2β-piperazino-(20R)-5α-pregnane-3α,20-diol N-derivatives as anti-leukemic agents

D. Poirier, J. Roy, R. Maltais, 2012, Steroids.

Blockade of the stimulatory effect of estrogens, OH-tamoxifen, OH-toremifene, droloxifene, and raloxifene on alkaline phosphatase activity by the antiestrogen EM-800 in human endometrial adenocarcinoma Ishikawa cells.

J. Simard, C. Labrie, D. Poirier, 1997, Cancer research.

Impact of estradiol structural modifications (18-methyl and/or 17-hydroxy inversion of configuration) on the in vitro and in vivo estrogenic activity

D. Poirier, J. Roy, D. Ayan, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Two non-reactive ternary complexes of estrogenic 17β-hydroxysteroid dehydrogenase: crystallization and preliminary structural analysis

R. Campbell, D. Poirier, Sheng-Xiang Lin, 1999, The Journal of Steroid Biochemistry and Molecular Biology.

A concerted, rational design of type 1 17β‐hydroxysteroid dehydrogenase inhibitors: estradiol‐adenosine hybrids with high affinity

R. Campbell, D. Poirier, Sheng-Xiang Lin, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models

F. Pouliot, D. Poirier, B. Neveu, 2017, PloS one.

Metal-based biologically active agents: Synthesis, characterization, antibacterial and antileukemia activity evaluation of Cu(II), V(IV) and Ni(II) complexes with antipyrine-derived compounds.

D. Poirier, T. Roșu, Simona Păsculescu, 2010, European journal of medicinal chemistry.

Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility.

D. Poirier, J. Roy, R. Maltais, 2019, European journal of medicinal chemistry.

In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships

V. Stavila, D. Poirier, J. Roy, 2008 .

Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity

D. Poirier, V. Paunescu, T. Roșu, 2016, Molecules.

D-ring allyl derivatives of 17β- and 17α-estradiols: Chemical synthesis and 13C NMR data

D. Poirier, P. Dionne, B. T. Ngatcha, 1997, Steroids.

A Convenient Synthetic Method for Alpha-Alkylation of Steroidal 17-Ketone: Preparation of 16β(THPO-Heptyl)-Estradiol

D. Poirier, M. Tremblay, S. Auger, 1995 .

Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity

D. Poirier, T. Roșu, E. Pahonțu, 2013, Molecules.

O-Methoxycarbonyl Cyanohydrin as a New Protective Group for Carbonyls

D. Poirier, D. Berthiaume, 2000 .

Unexpected formation of O-methoxycarbonyl cyanohydrin showing potential as a protective group of ketones

D. Poirier, R. Boivin, D. Berthiaume, 1999 .

N-butyl, N-methyl, 11-[3′,17′ β-(dihydroxy)-1′,3′,5′(10′)- estratrien-16′ α-yl]-9(R/S)-bromo undecanamide: synthesis and 17β-HSD inhibiting, estrogenic and antiestrogenic activities

D. Poirier, F. Labrie, J. D. Pelletier, 1994, Steroids.

First synthesis of a steroid containing an unstable 19-nor-androsta-1,5-dien-3-one system

D. Poirier, C. Cadot, A. Philip, 2006 .

Raman and infrared spectra of crystalline 9‐methyladenine and its methylmercury complexes

D. Poirier, R. Savoie, A. Beauchamp, 1981 .

Coordination compounds of cobalt, nickel, copper, and zinc with N1,N2-bis(pyridin-2-ylmethylidene)benzene-1,2-diamine and its derivatives

D. Poirier, E. Pahonțu, A. Gulea, 2014, Russian Journal of General Chemistry.

Coordination compounds of copper and nickel with N,N′-[4,4′-(perfluoro-1,4-phenylene)bis(oxy)bis(4,1-phenylene)]-bis[2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide] and its derivatives

D. Poirier, A. Gulya, V. Tsapkov, 2014, Russian Journal of General Chemistry.

Crystal structures of copper(II) chloride, copper(II) bromide, and copper(II) nitrate complexes with pyridine-2-carbaldehyde thiosemicarbazone

D. Poirier, E. Jeanneau, J. Roy, 2008 .

Development of a Gram-Scale Synthesis of PBRM, an Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1

D. Poirier, R. Maltais, 2019, Organic Process Research & Development.

Chemical synthesis of 2beta-amino-5alpha-androstane-3alpha,17beta-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells.

D. Poirier, J. Roy, Patrick DeRoy, 2008, Bioorganic & medicinal chemistry.

Sulfanilamide-containing coordination compounds of Cu(II) with isatin and N-methylisatin thiosemicarbazones

D. Poirier, J. Roy, A. Gulea, 2006 .

Diastereoselective Addition of Organomagnesium Reagents to 17β-TBDMS-Dihydrotestosterone

D. Poirier, B. T. Ngatcha, 1999 .

Sulfanilamide copper(II) chelates with 2-[(2-hydroxyphenyl-imino)methyl]phenolom and 1-[(2-hydroxyphenylimino)-methyl]naphthalen-2-ol

D. Poirier, A. Gulya, V. Tsapkov, 2010 .

Estradiol dimers as a new class of steroid sulfatase reversible inhibitors.

D. Poirier, D. Fournier, 2009, Bioorganic & medicinal chemistry letters.

Separation by thin-layer chromatography of the most common androgen-derived C19 steroids formed by mammalian cells☆

D. Poirier, Y. Tremblay, C. Blomquist, 1999, Steroids.

Synthesis of taxodione

D. Poirier, Michel Jean, R. H. Burnell, 1987 .

The structures of the nellionols. Synthesis of model abieta-8,11,13-trien-7-ones. Synthesis of 5-dehydronellionol trimethyl ether

D. Poirier, Michel Jean, S. Savard, 1984 .

Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer

R. Mansel, R. Mehta, N. Kim, 2002, Breast Cancer Research and Treatment.

The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers

D. Poirier, J. Roy, D. Ayan, 2015, PloS one.

17β-Hydroxysteroid dehydrogenase inhibitors: a patent review

D. Poirier, Donald Poirier, 2010, Expert opinion on therapeutic patents.

Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents

D. Poirier, J. Roy, R. Maltais, 2016, Steroids.

Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5α-androstane-3α,17β-diol derivatives.

D. Poirier, D. Ayan, R. Maltais, 2014, Bioorganic & medicinal chemistry.

A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells

D. Poirier, S. Desnoyers, J. Roy, 2012, Investigational New Drugs.

Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes

D. Poirier, J. Roy, R. Maltais, 2011, Molecular Diversity.

Chemical synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1

D. Poirier, J. Roy, R. Maltais, 2018, Steroids.

Inhibitors of type II 17β-hydroxysteroid dehydrogenase

D. Poirier, M. Tremblay, V. Luu‐The, 2001, Molecular and Cellular Endocrinology.

New cancer drugs targeting the biosynthesis of estrogens and androgens

D. Poirier, 2008 .

Overview of a rational approach to design type I 17β-hydroxysteroid dehydrogenase inhibitors without estrogenic activity: chemical synthesis and biological evaluation

D. Poirier, M. Tremblay, 1998, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis and evaluation of estradiol derivatives with 16α-(bromoalkylamide), 16α-(bromoalkyl) or 16α-(bromoalkynyl) side chain as inhibitors of 17β-hydroxysteroid dehydrogenase type 1 without estrogenic activity

D. Poirier, J. D. Pelletier, 1996 .

16α-propyl derivatives of estradiol as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

D. Poirier, R. Boivin, S. Auger, 1994 .

Steroid sulfatase inhibitors: A review covering the promising 2000–2010 decade

D. Poirier, R. Maltais, 2011, Steroids.

Steroid-converting enzymes in human ovarian carcinomas

M. Simard, D. Poirier, P. Argenta, 2009, Molecular and Cellular Endocrinology.

Parallel solid-phase synthesis of 3β-peptido-3α-hydroxy-5α-androstan-17-one derivatives for inhibition of type 3 17β-hydroxysteroid dehydrogenase

D. Poirier, R. Maltais, V. Luu‐The, 2001 .

A multidetachable sulfamate linker successfully used in a solid-phase strategy to generate libraries of sulfamate and phenol derivatives.

D. Poirier, Marie Bérubé, L. Ciobanu, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of a First Estradiol-Adenosine Hybrid Compound

D. Poirier, Sheng-Xiang Lin, R. Boivin, 2003 .

Solid-phase synthesis of hydroxysteroid derivatives using the diethylsilyloxy linker.

D. Poirier, R. Maltais, M. Tremblay, 2000, Journal of combinatorial chemistry.

Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase

D. Poirier, J. Roy, R. Maltais, 2013, Molecular and Cellular Endocrinology.

Nonsteroidal compounds designed to mimic potent steroid sulfatase inhibitors

D. Poirier, V. Luu‐The, L. Ciobanu, 2002, The Journal of Steroid Biochemistry and Molecular Biology.

Inhibitors of 17β-Hydroxysteroid Dehydrogenases

D. Poirier, 2003 .

Steroid sulfatase inhibitors

D. Poirier, R. Maltais, L. Ciobanu, 1999 .

Synthesis of a First Estradiol-Adenosine Hybrid Compound.

D. Poirier, Sheng-Xiang Lin, R. Boivin, 2004 .

Chemical synthesis of 16β-propylaminoacyl derivatives of estradiol and their inhibitory potency on type 1 17β-hydroxysteroid dehydrogenase and binding affinity on steroid receptors

D. Poirier, Sheng-Xiang Lin, M. Tremblay, 2001, Steroids.

A 6beta-(thiaheptanamide) derivative of estradiol as inhibitor of 17beta-hydroxysteroid dehydrogenase type 1.

D. Poirier, P. Dionne, S. Auger, 1998, The Journal of steroid biochemistry and molecular biology.

N-butyl, N-methyl, 11-[3',17' beta-(dihydroxy)-1',3',5'(10')-estratrien-16' alpha-yl]-9(R/S)-bromo undecanamide: synthesis and 17 beta-HSD inhibiting, estrogenic and antiestrogenic activities.

D. Poirier, F. Labrie, J. D. Pelletier, 1994, Steroids.

Steroid-hindered 17β-tertiary alcohol: Characterization of dehydrated compounds

D. Poirier, K. Sam, P. Bydal, 1996, Steroids.

Synthesis of 17β-estradiol derivatives with n-butyl, n-methyl alkylamide side chain at position 15

D. Poirier, F. Labrie, Y. Mérand, 1991 .

Spironolactone-related inhibitors of type II 17beta-hydroxysteroid dehydrogenase: chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities.

D. Poirier, F. Labrie, M. Tremblay, 1999, Bioorganic & medicinal chemistry.

A Sequential Dual Cleavage of the Arylsulfamate Linker to Provide Both Sulfamate and Phenol Derivatives

D. Poirier, D. Fournier, L. Ciobanu, 2015 .

Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities.

D. Poirier, F. Labrie, V. Luu‐The, 2009, European journal of medicinal chemistry.

Estrogen receptor‐α mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17α‐hydroxylase/17,20 μlyase) expression

K. Korach, J. F. Couse, K. Rodriguez, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

3β-Alkyl-androsterones as inhibitors of type 3 17β-hydroxysteroid dehydrogenase: Inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines

D. Poirier, F. Labrie, Yannick Laplante, 2006, Molecular and Cellular Endocrinology.

Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells

D. Poirier, V. Luu‐The, Béatrice Tchédam-Ngatcha, 2002, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of type 2 17β-hydroxysteroid dehydrogenase by estradiol derivatives bearing a lactone on the D-ring: structure–activity relationships

D. Poirier, S. Auger, P. Bydal, 2004, Steroids.

C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation.

D. Poirier, C. Cadot, Yannick Laplante, 2007, Bioorganic & medicinal chemistry.

Intracellular regulation of 17 beta-hydroxysteroid dehydrogenase type 2 catalytic activity in A431 cells.

D. Poirier, C. Beaudoin, Y. Tremblay, 1997, The Journal of endocrinology.

The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad.

K. Korach, J. F. Couse, K. Rodriguez, 2006, Endocrinology.

Wide spectrum of steroids serving as substrates for the formation of lipoidal derivatives in ZR-75-1 human breast cancer cells.

D. Poirier, F. Labrie, A. Bélanger, 1990, Journal of steroid biochemistry.

Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3.

D. Poirier, J. Roy, R. Maltais, 2015, Bioorganic & medicinal chemistry.

Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors.

F. Spyrakis, S. Oliaro-Bosso, D. Poirier, 2019, Biochimie.

Estrogen formation in endometrial and cervix cancer cell lines: Involvement of aromatase, steroid sulfatase and 17β-hydroxysteroid dehydrogenases (types 1, 5, 7 and 12)

D. Poirier, M. Fournier, 2009, Molecular and Cellular Endocrinology.

Molecular therapy of breast cancer: progress and future directions

D. Poirier, Sheng-Xiang Lin, A. Azzi, 2010, Nature Reviews Endocrinology.

Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase.

D. Poirier, F. Labrie, C. Martel, 2003, Cancer research.

Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases

D. Poirier, J. Roy, R. Maltais, 2021, Steroids.

Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group.

D. Poirier, R. Boivin, V. Luu‐The, 2001, European journal of medicinal chemistry.

Synthesis of 3-spiromorpholinone androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3.

D. Poirier, J. Roy, L. Kenmogne, 2013, Bioorganic & medicinal chemistry letters.

Development of 3-substituted-androsterone derivatives as potent inhibitors of 17β-hydroxysteroid dehydrogenase type 3.

D. Poirier, M. Fournier, R. Maltais, 2011, Bioorganic & medicinal chemistry.

Viability screen on pediatric low grade glioma cell lines unveils a novel anti-cancer drug of the steroid biosynthesis inhibitor family.

Chris Jones, Chris Jones, D. Poirier, 2013, Cancer letters.

Identification of drostanolone and 17-methyldrostanolone metabolites produced by cryopreserved human hepatocytes

D. Poirier, C. Ayotte, J. Gauthier, 2009, Steroids.

Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel

D. Poirier, J. Roy, R. Maltais, 2021, International journal of molecular sciences.

In vitro evaluation of a tetrahydroisoquinoline derivative as a steroid sulfatase inhibitor and a selective estrogen receptor modulator

D. Poirier, C. Ouellet, Etienne Ouellet, 2015, Investigational New Drugs.

Recent patents on new steroid agents targeting the steroidogenesis for endocrine cancer treatments.

D. Poirier, 2015, Recent Patents on Endocrine Metabolic & Immune Drug Discovery.

Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses

D. Lamarre, V. Titorenko, D. Poirier, 2020, Scientific Reports.

Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase type 3 for optical imaging.

D. Poirier, R. Maltais, L. Kenmogne, 2016, Bioorganic & medicinal chemistry letters.

Investigation of a tetrahydroisoquinoline scaffold as dual-action steroid sulfatase inhibitors generated by parallel solid-phase synthesis

D. Poirier, R. Maltais, C. Ouellet, 2013 .

Chemical synthesis, characterisation and biological evaluation of furanic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1.

D. Poirier, S. Farhane, Yannick Laplante, 2011, Medicinal chemistry (Shariqah (United Arab Emirates)).

17β-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in addition to Estradiol Production

D. Poirier, Sheng-Xiang Lin, M. Mazumdar, 2010 .

Design and Synthesis of Bisubstrate Inhibitors of Type 1 17β-Hydroxysteroid Dehydrogenase: Overview and Perspectives

D. Poirier, Sheng-Xiang Lin, M. Mazumdar, 2009 .

Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model

D. Poirier, J. Roy, R. Maltais, 2018, Investigational New Drugs.

N-Butyl-N-methyl-11-(3'-hydroxy-21',17'-carbolactone-19'-nor-17'α-pregna-1',3',5'(10')-trien-7'α-yl)-undecanamide: an inhibitor of type 2 17β-hydroxysteroid dehydrogenase that does not have oestrogenic or androgenic activity

D. Poirier, F. Labrie, K. Sam, 2000 .

Hormonal Regulation of Estradiol 17β‐Hydroxysteroid Dehydrogenase Activity in the ZR‐75‐1 Human Breast Cancer Cell Line

S. Tremblay, D. Poirier, F. Labrie, 1990 .

Extensive esterification of adrenal C19-delta 5-sex steroids to long-chain fatty acids in the ZR-75-1 human breast cancer cell line.

D. Poirier, F. Labrie, A. Bélanger, 1989, The Journal of biological chemistry.

Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase.

D. Poirier, D. Fournier, 2011, European journal of medicinal chemistry.

Description of Chemical Synthesis, Nuclear Magnetic Resonance Characterization and Biological Activity of Estrane-Based Inhibitors/Activators of Steroidogenesis

D. Poirier, 2023, Molecules.

Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone

D. Poirier, J. Roy, R. Maltais, 2023, Molecules.

Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.

D. Poirier, V. Luu‐The, É. Bellavance, 2009, Journal of medicinal chemistry.

C16 and C17 derivatives of estradiol as inhibitors of 17 beta-hydroxysteroid dehydrogenase type 1: chemical synthesis and structure-activity relationships.

D. Poirier, R. Boivin, M. Tremblay, 1998, Drug design and discovery.

Steroidal spiro-gamma-lactones that inhibit 17 beta-hydroxysteroid dehydrogenase activity in human placental microsomes.

D. Poirier, V. Luu‐The, S. Auger, 1995, Journal of medicinal chemistry.

Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties.

P. Lagüe, D. Poirier, R. Maltais, 2016, European journal of medicinal chemistry.

Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol

D. Poirier, D. Ayan, R. Maltais, 2011, ACS medicinal chemistry letters.

Regiospecificity and Stereospecificity of Human UDP-Glucuronosyltransferases in the Glucuronidation of Estriol, 16-Epiestriol, 17-Epiestriol, and 13-Epiestradiol

M. Finel, D. Poirier, L. Laakkonen, 2013, Drug Metabolism and Disposition.

Detection of 5α-androst-2-en-17-one and variants: Identification of main urinary metabolites in human urine samples by GC-MS and NMR.

D. Poirier, C. Ayotte, A. Charlebois, 2016, Drug testing and analysis.

Identification of a first enzymatic activator of a 17β-hydroxysteroid dehydrogenase.

D. Poirier, R. Maltais, Alexandre Trottier, 2014, ACS chemical biology.

A Concise, Gram-Scale Total Synthesis of Protectin DX and Related Labeled Versions via a Key Stereoselective Reduction of Enediyne.

A. Marette, D. Poirier, R. Maltais, 2023, The Journal of organic chemistry.

Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol.

D. Poirier, F. Labrie, R. Boivin, 1999, Journal of medicinal chemistry.

Advances in development of inhibitors of 17beta hydroxysteroid dehydrogenases.

D. Poirier, 2009, Anti-cancer agents in medicinal chemistry.

Chemical Synthesis, 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activity and Assessment of In Vitro and In Vivo Estrogenic Activities of Estradiol Derivatives

D. Poirier, M. Fournier, François Rouillard, 2008 .

Androsterone 3β-substituted derivatives as inhibitors of type 3 17β-hydroxysteroid dehydrogenase

D. Poirier, V. Luu‐The, B. T. Ngatcha, 2000 .

Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.

D. Poirier, M. Tremblay, V. Luu‐The, 2001, Molecular and cellular endocrinology.

Androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase.

D. Poirier, V. Luu‐The, B. T. Ngatcha, 2000, Bioorganic & medicinal chemistry letters.

Comparison of sex steroid synthesis between neonatal and adult rat hippocampus

K. Nakajima, S. Kawato, D. Poirier, 2009, Neuroscience Research.

Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency.

D. Poirier, J. Roy, R. Maltais, 2020, European journal of medicinal chemistry.

Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133

D. Poirier, Raphaël Dutour, R. Maltais, 2016, Steroids.

Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging.

Jean-Philippe Lambert, D. Poirier, J. Roy, 2020, Bioorganic & medicinal chemistry.

Synthesis and pharmacokinetic study of poly(ethylene oxide) triazole dendrimers decorated with aminosteroids as anticancer agent

D. Poirier, Jean‐François Morin, J. Roy, 2020 .

17β‐hydroxysteroid dehydrogenase type 2 activity, expression and cellular localization in abdominal adipose tissues from women

D. Poirier, A. Tchernof, M. Pelletier, 2022, Clinical endocrinology.

Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17&bgr;‐hydroxysteroid dehydrogenase type 1

P. Lagüe, D. Poirier, J. Roy, 2017, Biochemical pharmacology.

Chemical synthesis and biological activities of 16α-derivatives of 5α-androstane-3α,17β-diol as antiandrogens

D. Poirier, R. Breton, F. Labrie, 2007 .

An Aminosteroid Derivative Shows Higher In Vitro and In Vivo Potencies than Gold Standard Drugs in Androgen-Dependent Prostate Cancer Models

D. Poirier, J. Roy, R. Maltais, 2023, Cancers.

Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments

D. Poirier, J. Roy, R. Maltais, 2023, Journal of clinical medicine.

Design of a Mestranol 2‐N‐Piperazino‐Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF‐7 Breast Cancer Models

D. Poirier, J. Roy, Raphaël Dutour, 2017, ChemMedChem.

Chemical synthesis, NMR characterization, and anticancer activity of androstene derivatives with a C17-side chain

D. Poirier, J. Roy, Adrien Djiemeny Ngueta, 2022, Steroids.

16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2021, The Journal of Steroid Biochemistry and Molecular Biology.

A- and D-ring structural modifications of an androsterone derivative inhibiting 17β-hydroxysteroid dehydrogenase type 3: Chemical synthesis and structure-activity relationships.

D. Poirier, J. Roy, Francisco Cortés-Benítez, 2019, Journal of medicinal chemistry.

NMR-Assisted Structure Elucidation of an Anticancer Steroid-β-Enaminone Derivative

D. Poirier, R. Maltais, 2017 .

Parallel Solid-Phase Synthesis using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines.

D. Poirier, J. Roy, Raphaël Dutour, 2019, Anti-cancer agents in medicinal chemistry.

Steroids and combinatorial chemistry.

D. Poirier, M. Tremblay, R. Maltais, 2004, Journal of combinatorial chemistry.

Synthesis of Libraries of 16β‐Aminopropyl Estradiol Derivatives for Targeting Two Key Steroidogenic Enzymes

D. Poirier, L. Ciobanu, 2006, ChemMedChem.

Steroids and Combinatorial Chemistry

D. Poirier, M. Tremblay, R. Maltais, 2004 .

Design, Synthesis and In Vitro Evaluation of 4-Androstene-3,17-dione/Adenosine Hybrid Compounds as Bisubstrate Inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase

D. Poirier, Marie Bérubé, Yannick Laplante, 2006 .

Reprint of “In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3”

D. Poirier, J. Roy, M. Fournier, 2014, The Journal of Steroid Biochemistry and Molecular Biology.

In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3

D. Poirier, J. Roy, M. Fournier, 2014, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17β-hydroxysteroid dehydrogenase (17-β-HSD type 1)

D. Poirier, M. Tremblay, S. Auger, 1995 .

Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD type 1).

D. Poirier, M. Tremblay, S. Auger, 1995, Bioorganic & medicinal chemistry.

Solid-phase parallel synthesis of 17alpha-substituted estradiol sulfamate and phenol libraries using the multidetachable sulfamate linker.

D. Poirier, L. Ciobanu, 2003, Journal of combinatorial chemistry.

3β-Sulfamate Derivatives of C19 and C21 Steroids Bearing a t -Butylbenzyl or a Benzyl Group: Synthesis and Evaluation as Non-estrogenic and Non-androgenic Steroid Sulfatase Inhibitors

D. Poirier, R. Boivin, V. Luu‐The, 2003, Journal of enzyme inhibition and medicinal chemistry.

Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase.

D. Poirier, F. Labrie, R. Boivin, 2000, Journal of medicinal chemistry.

A Potent Inhibitor of Steroid Sulfatase (EM-1913) Blocks Tumor Growth in Nude Mice (MCF-7 Xenograft)

D. Poirier, J. Roy, D. Ayan, 2015 .

Quantitative Structure-Activity Relationship (QSAR) Study with a Series of 17α-Derivatives of Estradiol: Model for the Development of Reversible Steroid Sulfatase Inhibitors

D. Poirier, R. Maltais, D. Fournier, 2009 .

Synthesis and Biologic Properties of Some 1-(Alchyl)Phenyl-3-(4-(3-(Pyridin-2-Il)Acryloyl)Phenylthiourea

D. Poirier, J. Roy, A. Gulea, 2013 .

Regio- and stereo-specificity of the human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol and 13-epiestradiol

D. Poirier, L. Laakkonen, Nina Sneitz, 2013 .

Identification of a 17β‐Hydroxysteroid Dehydrogenase Type 10 Steroidal Inhibitor: A Tool to Investigate the Role of Type 10 in Alzheimer’s Disease and Prostate Cancer

D. Poirier, D. Ayan, R. Maltais, 2012, ChemMedChem.

Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses

D. Lamarre, V. Titorenko, D. Poirier, 2020, Scientific Reports.

Improved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17β-hydroxysteroid dehydrogenase type 1

D. Poirier, Marie Bérubé, 2009, Journal of enzyme inhibition and medicinal chemistry.

Chemical synthesis of 2beta-amino-5alpha-androstane-3alpha,17beta-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells.

D. Poirier, J. Roy, Patrick DeRoy, 2008, Bioorganic & medicinal chemistry.

2β-(N-Substituted Piperazino)-5α-Androstane-3α,17β-Diols: Parallel Solid-Phase Synthesis and Antiproliferative Activity on Human Leukemia HL-60 Cells

D. Poirier, J. Roy, Patrick DeRoy, 2007 .

Crystal structures of nitrato-{2-[2-(1-pyridine-2-ylethylidene)hydrazine]-1,3-benzothiazolo}aquacopper and chloro-{2-[2-phenyl(pyridine-2-ylethylidene)hydrazine]-1,3-benzothiazolo}copper

D. Poirier, P. Petrenko, Y. Chumakov, 2015 .

17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production.

D. Poirier, Sheng-Xiang Lin, M. Mazumdar, 2010, Molecular endocrinology.

A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: an integrated biological function and inhibition study.

J. Adamski, D. Poirier, S. Lin, 2013, Current topics in medicinal chemistry.

Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide.

D. Poirier, Sheng-Xiang Lin, Tang Li, 2018, The journal of physical chemistry letters.

Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.

C. Doillon, Xiaoqiang Wang, C. Gérard, 2015, Journal of molecular cell biology.

Androsterone 3alpha-ether-3beta-substituted and androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: chemical synthesis and structure-activity relationship.

D. Poirier, F. Labrie, V. Luu‐The, 2005, Journal of medicinal chemistry.

A solution-phase combinatorial parallel synthesis of 3β-amido-3α-hydroxy-5α-androstane-17-ones

D. Poirier, R. Maltais, 1998 .

Chemical Synthesis and NMR Characterization of Non Steroidal Mimics of an Estradiol Derivative Used as Inhibitor of 17beta-Hydroxysteroid Dehydrogenase Type 1

D. Poirier, R. Maltais, C. Ouellet, 2012 .

Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity

P. Lagüe, D. Poirier, R. Maltais, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis and antiestrogenic activity of diaryl thioether derivatives.

J. Simard, D. Poirier, F. Labrie, 1994, Journal of medicinal chemistry.