G. Allan

发表

Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms.

Nareshkumar Jain, Jiayi Xu, R. Kanojia, 2009, Journal of medicinal chemistry.

Cell type-specific bidirectional regulation of the glucocorticoid-induced leucine zipper (GILZ) gene by estrogen

G. Allan, S. Lundeen, S. Tynan, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

An ultrahigh-throughput screening assay for estrogen receptor ligands.

G. Allan, G F Allan, A. Hutchins, 1999, Analytical biochemistry.

Induction of the progesterone receptor gene in estrogen target cells monitored by branched DNA signal amplification☆ ☆ This work originated at the R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, USA.

G. Allan, Xiulin Liu, A. Hutchins, 2001, Steroids.

A selective androgen receptor modulator that reduces prostate tumor size and prevents orchidectomy-induced bone loss in rats

Muh-Tsann Lai, G. Allan, S. Lundeen, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding.

B. O’Malley, M. Tsai, S. Tsai, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

D. Edwards, B. O’Malley, M. Tsai, 1992, The Journal of biological chemistry.

Identification of Genes with Differential Regulation in Primate Endometrium During the Proliferative and Secretory Phases of the Cycle

M. Erlander, S. Palmer, G. Allan, 2003, Endocrine research.

Pharmacological characterization of an imidazolopyrazole as novel selective androgen receptor modulator

P. Tannenbaum, Muh-Tsann Lai, G. Allan, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

A selective androgen receptor modulator with minimal prostate hypertrophic activity restores lean body mass in aged orchidectomized male rats

Muh-Tsann Lai, G. Allan, S. Lundeen, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats

P. Tannenbaum, Muh-Tsann Lai, G. Allan, 2007, Endocrine.

Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators.

G. Allan, S. Lundeen, Z. Sui, 2006, Bioorganic & medicinal chemistry letters.

Discovery of novel phosphorus-containing steroids as selective glucocorticoid receptor antagonist.

P. Tannenbaum, Weiqin Jiang, G. Allan, 2007, Bioorganic & medicinal chemistry letters.

Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands.

X. Li, Amy Musto, G. Allan, 2006, Bioorganic & medicinal chemistry letters.

Design, synthesis, and in vivo SAR of a novel series of pyrazolines as potent selective androgen receptor modulators.

X. Li, G. Allan, S. Lundeen, 2007, Journal of medicinal chemistry.

Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators.

X. Li, G. Allan, S. Lundeen, 2007, Bioorganic & medicinal chemistry letters.

Recombinant human glucocorticoid receptor induces transcription of hormone response genes in vitro.

B. O’Malley, M. Tsai, S. Tsai, 1990, The Journal of biological chemistry.

The putative tumor suppressor deleted in malignant brain tumors 1 is an estrogen-regulated gene in rodent and primate endometrial epithelium.

M. D'Andrea, E. Pacia, G. Allan, 2005, Endocrinology.

Synergism between steroid response and promoter elements during cell-free transcription.

B. O’Malley, M. Tsai, S. Tsai, 1991, Journal of Biological Chemistry.

Estrogen and Progesterone Receptors

G. Allan, 2001 .

Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness.

Nareshkumar Jain, Jiayi Xu, R. Kanojia, 2006, Journal of medicinal chemistry.

Synthesis of potent and tissue-selective androgen receptor modulators (SARMs): 2-(2,2,2)-Trifluoroethyl-benzimidazole scaffold.

G. Allan, S. Lundeen, Z. Sui, 2007, Bioorganic & medicinal chemistry letters.

β-Alkylthio indolyl carbinols: Potent nonsteroidal antiandrogens with oral efficacy in a prostate cancer model

Muh-Tsann Lai, G. Allan, R. Russell, 2007 .

The discovery of a potent orally efficacious indole androgen receptor antagonist through in vivo screening.

Weiqin Jiang, Muh-Tsann Lai, G. Allan, 2007, Bioorganic & medicinal chemistry letters.

A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands.

Amy Musto, G. Allan, D. Hahn, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists.

P. Tannenbaum, Xin Chen, Nareshkumar Jain, 2009, Bioorganic & medicinal chemistry letters.

New progesterone receptor antagonists: phosphorus-containing 11beta-aryl-substituted steroids.

P. Tannenbaum, Weiqin Jiang, G. Allan, 2006, Bioorganic & medicinal chemistry.

Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives.

G. Allan, S. Lundeen, Z. Sui, 2007, Bioorganic & medicinal chemistry letters.

Progesterone receptor agonists and antagonists

G. Allan, M. Macielag, 1999 .

Therapeutic androgen receptor ligands

G. Allan, Z. Sui, 2003, Nuclear receptor signaling.

Steroid hormone receptors and In vitro transcription

B. O’Malley, M. Tsai, S. Tsai, 1991, BioEssays : news and reviews in molecular, cellular and developmental biology.

The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex

B. O’Malley, L. Klein-Hitpass, S. Tsai, 1990, Cell.

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

B. O’Malley, M. Tsai, G. Allan, 1992, Cell.

Detection of potential ligands for nuclear receptors in cellular extracts.

C. Thaller, A. Cooney, B. O’Malley, 1994, Endocrinology.

Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities.

G. Allan, S. Lundeen, Z. Sui, 2007, Bioorganic & medicinal chemistry letters.

Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists.

P. Tannenbaum, Xin Chen, Nareshkumar Jain, 2007, Bioorganic & medicinal chemistry letters.

Insight from molecular modeling into different conformation and SAR of natural steroids and unnatural 7-oxa-steroids.

P. Tannenbaum, Xin Chen, Nareshkumar Jain, 2008, Bioorganic & medicinal chemistry letters.

Novel phosphorus-containing 17β-side chain mifepristone analogues as progesterone receptor antagonists

P. Tannenbaum, Weiqin Jiang, Xin Chen, 2006, Steroids.

Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists.

P. Tannenbaum, Xin Chen, Nareshkumar Jain, 2007, Bioorganic & medicinal chemistry letters.

Molecular properties and preclinical pharmacology of JNJ-1250132, a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro

S. Palmer, Muh-Tsann Lai, Amy Musto, 2006, Steroids.

Nonsteroidal progesterone receptor ligands with unprecedented receptor selectivity

S. Palmer, Muh-Tsann Lai, G. Allan, 2000, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis of Potent and Tissue-Selective Androgen Receptor Modulators (SARMs): 2-(2,2,2)-Trifluoroethylbenzimidazole Scaffold.

G. Allan, S. Lundeen, J. Lanter, 2007 .

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

B. O’Malley, M. Tsai, S. Tsai, 1993, Molecular endocrinology.

2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgen receptor antagonists.

G. Allan, S. Lundeen, Z. Sui, 2007, Bioorganic & medicinal chemistry letters.

Induction of a novel conformation in the progesterone receptor by ZK299 involves a defined region of the carboxyl-terminal tail.

S. Palmer, G. Allan, C. Campen, 1996, Molecular Endocrinology.