V. Tryndyak

I. Pogribny, V. Tryndyak, M. Churchwell, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.

T. Bagnyukova, I. Pogribny, V. Tryndyak, 2008, Carcinogenesis.

Identification of chromatin‐accessible domains in non‐alcoholic steatohepatitis‐derived hepatocellular carcinoma

W. Xiao, I. Pogribny, M. L. Dechassa, 2018, Molecular carcinogenesis.

Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro.

Thilak K. Mudalige, Tao Chen, I. Pogribny, 2017, Toxicology letters.

Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells.

I. Pogribny, O. Yurchenko, V. Tryndyak, 2006, Cancer letters.

In vivo expression and characteristics of novel α‐d‐mannose‐rich glycoprotein markers of apoptotic cells

U. Hellman, V. Tryndyak, R. Stoika, 2005, Cell biology international.

Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation

I. Pogribny, S. Ross, O. Orisakwe, 2017, Molecular Cancer Research.

The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway.

I. Koturbash, I. Pogribny, V. Tryndyak, 2013, Carcinogenesis.

Interstrain differences in liver injury and one‐carbon metabolism in alcohol‐fed mice

I. Rusyn, I. Pogribny, O. Kosyk, 2012, Hepatology.

Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high‐fat diet in the genetically diverse Collaborative Cross mouse model

I. Rusyn, I. Pogribny, S. Ross, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells

Thilak K. Mudalige, I. Pogribny, O. Orisakwe, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis

I. Rusyn, I. Pogribny, V. Tryndyak, 2017, Oncotarget.

Butyrate-containing structured lipids inhibit RAC1 and epithelial-to-mesenchymal transition markers: A chemopreventive mechanism against hepatocarcinogenesis.

I. Rusyn, I. Pogribny, V. Tryndyak, 2020, The Journal of nutritional biochemistry.

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.

I. Rusyn, T. Bagnyukova, I. Pogribny, 2009, Journal of hepatology.

Nifedipine toxicity is exacerbated by acetyl l‐carnitine but alleviated by low‐dose ketamine in zebrafish in vivo

V. Tryndyak, Syed F. Ali, J. Kanungo, 2020, Journal of applied toxicology : JAT.

MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency.

I. Pogribny, V. Tryndyak, L. Muskhelishvili, 2016, The Journal of nutritional biochemistry.

Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.

I. Rusyn, I. Pogribny, C. Woods, 2007, Mutation research.

Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells

I. Pogribny, R. Silvestri, V. Tryndyak, 2015, Cancer biology & therapy.

Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

J. Fuscoe, T. Han, I. Pogribny, 2016, BMC Genomics.

Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism.

I. Pogribny, M. Pogribna, S. Ross, 2014, The Journal of nutritional biochemistry.

Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet

T. Han, I. Pogribny, V. Tryndyak, 2008, Brain Research.

Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.

I. Koturbash, I. Pogribny, V. Tryndyak, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas

V. Tryndyak, M. Orloff, Mohammed S Orloff, 2022, Science of The Total Environment.

RESISTANCE OF GUERIN S CARCINOMA CELLS TO CISPLATINE : BIOCHEMICAL AND MORPHOLOGICAL ASPECTS

O. Yurchenko, V. Tryndyak, V. Chekhun, 2022 .

Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study

I. Pogribny, V. Tryndyak, F. Beland, 2017, Archives of Toxicology.

Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.

J. Fuscoe, T. Han, I. Pogribny, 2011, Molecular nutrition & food research.

Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice.

I. Pogribny, S. J. James, V. Tryndyak, 2014, Molecular nutrition & food research.

Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice.

I. Rusyn, I. Pogribny, V. Tryndyak, 2022, The Journal of nutritional biochemistry.

Persistence of furan-induced epigenetic aberrations in the livers of F344 rats.

J. Fuscoe, T. Han, I. Pogribny, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

From the Cover: Aloin, a Component of the Aloe Vera Plant Leaf, Induces Pathological Changes and Modulates the Composition of Microbiota in the Large Intestines of F344/N Male Rats

V. Tryndyak, F. Beland, G. Olson, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis.

I. Rusyn, I. Pogribny, A. Sanyal, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Epigenetically mediated inhibition of S‐adenosylhomocysteine hydrolase and the associated dysregulation of 1‐carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma

I. Rusyn, I. Pogribny, M. Pogribna, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver.

I. Pogribny, V. Tryndyak, L. Muskhelishvili, 2014, Toxicology.

Strain‐dependent dysregulation of one‐carbon metabolism in male mice is associated with choline‐ and folate‐deficient diet‐induced liver injury

I. Rusyn, I. Pogribny, M. Pogribna, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet

T. Bagnyukova, I. Pogribny, Christine L. Powell, 2008, Brain Research.

Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.

I. Rusyn, T. Bagnyukova, I. Pogribny, 2008, Mutation research.

Epigenetic reprogramming of liver cells in tamoxifen‐induced rat hepatocarcinogenesis

O. Kovalchuk, I. Pogribny, S. Ross, 2007, Molecular carcinogenesis.

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.

Ivan Rusyn, Eric F Lock, Oksana Kosyk, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin

Andrey Golubov, Olga Kovalchuk, O. Kovalchuk, 2010, International journal of cancer.

Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications, and Aberrant microRNA Expression

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2007, Cell cycle.

Epigenetic changes induced by methionine-supplemented and methionine-deficient diets in mice liver.

V. Tryndyak, L. C. Hernandes, A. de Conti, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Role of ferritin alterations in human breast cancer cells

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2011, Breast Cancer Research and Treatment.

Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats.

L. Poirier, I. Pogribny, M. Pogribna, 2006, Carcinogenesis.

Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.

I. Pogribny, M. Pogribna, V. Tryndyak, 2013, International journal of oncology.

Methyl deficiency, alterations in global histone modifications, and carcinogenesis.

I. Rusyn, I. Pogribny, S. Ross, 2007, The Journal of nutrition.

Fractionated Low-Dose Radiation Exposure Leads to Accumulation of DNA Damage and Profound Alterations in DNA and Histone Methylation in the Murine Thymus

O. Kovalchuk, I. Koturbash, I. Pogribny, 2005, Molecular Cancer Research.

The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene.

I. Pogribny, V. Tryndyak, L. Muskhelishvili, 2011, Mutation research.

The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.

I. Pogribny, V. Tryndyak, L. Muskhelishvili, 2009, Toxicology and applied pharmacology.

Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure.

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2007, Mutation research.

An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression

I. Pogribny, V. Tryndyak, F. Beland, 2012, Breast Cancer Research and Treatment.

Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin.

I. Pogribny, V. Tryndyak, F. Beland, 2013, International journal of oncology.

Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats.

I. Pogribny, V. Tryndyak, F. Beland, 2010, Carcinogenesis.

Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2007, Molecular Cancer Therapeutics.

Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo.

R. J. McDonald, O. Kovalchuk, I. Koturbash, 2007, Carcinogenesis.

E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells

I. Pogribny, V. Tryndyak, F. Beland, 2010, International journal of cancer.

Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum

I. Pogribny, S. J. James, V. Tryndyak, 2014, PloS one.

Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

J. Fuscoe, T. Han, I. Pogribny, 2016, BMC Genomics.

Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study.

I. Pogribny, V. Tryndyak, M. Churchwell, 2019, Chemical research in toxicology.

Role of epigenetics in tumor induction by non-genotoxic carcinogens

V. Tryndyak, 2017 .

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein

I. Pogribny, M. Pogribna, V. Tryndyak, 2016, Oncotarget.

Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet

I. Rusyn, I. Pogribny, A. Sanyal, 2022, Epigenetics.

Gene Expression and DNA Methylation Alterations During Non-alcoholic Steatohepatitis-Associated Liver Carcinogenesis

I. Pogribny, V. Tryndyak, F. Beland, 2019, Front. Genet..

Differentially expressed MicroRNAs provide mechanistic insight into fibrosis‐associated liver carcinogenesis in mice

I. Rusyn, I. Pogribny, T. Uehara, 2016, Molecular carcinogenesis.

Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype

I. Pogribny, M. Pogribna, V. Tryndyak, 2012, Epigenetics.

Epigenetic effects of low-level sodium arsenite exposure on human liver HepaRG cells

I. Pogribny, V. Tryndyak, F. Beland, 2020, Archives of Toxicology.

MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells.

I. Pogribny, V. Tryndyak, F. Beland, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells.

O. Kovalchuk, I. Pogribny, V. Tryndyak, 2006, Analytical biochemistry.

Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency.

L. Poirier, Y. Dragan, I. Pogribny, 2006, Mutation research.

Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach

V. Tryndyak, B. Lyn‐Cook, A. Starlard-Davenport, 2013, Journal of carcinogenesis.

Epigenetic down-regulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats

T. Bagnyukova, I. Pogribny, S. Ross, 2008, Cell cycle.

Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay

N. Mei, I. Pogribny, V. Tryndyak, 2019, Archives of Toxicology.

Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.

I. Rusyn, I. Pogribny, S. Ross, 2012, Toxicology and applied pharmacology.

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

W. Xiao, Tieliu Shi, Leming Shi, 2018, Archives of Toxicology.

' s personal copy Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline-and folate-de fi cient diet ☆

I. Rusyn, I. Pogribny, S. Ross, 2012 .

Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment

N. Mei, V. Tryndyak, Xiaoqing Guo, 2020, Journal of toxicology and environmental health. Part A.

Mechanistic evaluation of black cohosh extract-induced genotoxicity in human cells.

N. Mei, K. Witt, M. Manjanatha, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Epigenetic Alterations in Liver of C57BL/6J Mice after Short-Term Inhalational Exposure to 1,3-Butadiene

I. Rusyn, I. Koturbash, I. Pogribny, 2010, Environmental health perspectives.

Genetic and epigenetic changes in fibrosis‐associated hepatocarcinogenesis in mice

I. Rusyn, I. Pogribny, T. Uehara, 2014, International journal of cancer.

Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis.

O. Kovalchuk, J. Fuscoe, T. Han, 2007, Toxicology and applied pharmacology.

Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism

I. Rusyn, J. Fuscoe, T. Han, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Dietary Methyl Deficiency, microRNA Expression and Susceptibility to Liver Carcinogenesis

I. Rusyn, I. Pogribny, O. Kosyk, 2011, Lifestyle Genomics.

Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.

I. Rusyn, I. Pogribny, O. Kosyk, 2010, World review of nutrition and dietetics.

Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats.

I. Pogribny, S. Ross, V. Tryndyak, 2008, Nutrition reviews.

Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure.

I. Pogribny, V. Tryndyak, F. Beland, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Gene expression analyses reveal potential mechanism of inorganic arsenic-induced apoptosis in zebrafish.

V. Tryndyak, F. Beland, S. Fitzpatrick, 2023, Journal of applied toxicology : JAT.