D. Grainger

Steven C. R. Williams, D. Menon, D. Grainger, 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Feedback Mechanism of Focal Vascular Lesion Formation in Transgenic Apolipoprotein(a) Mice*

E. Rubin, A. Pearle, R. Lawn, 1996, The Journal of Biological Chemistry.

Effects of TGF-β on vascular smooth muscle cell growth

P. Weissberg, D. Grainger, J. Metcalfe, 1993 .

Tamoxifen: Teaching an old drug new tricks?

D. Grainger, J. Metcalfe, 1996, Nature Medicine.

The role of serum TGF-beta isoforms as potential markers of osteoporosis.

T. Spector, D. Grainger, M. Chiano, 1999, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.

Increased PAI activity and PAI-1 antigen occurring with an oral fat load: associations with PAI-1 genotype and plasma active TGF-beta levels.

S. Humphries, N. Wareham, D. Grainger, 1998, Atherosclerosis.

Broad-Spectrum Chemokine Inhibition Reduces Vascular Macrophage Accumulation and Collagenolysis Consistent with Plaque Stabilization in Mice

D. Grainger, E. McKilligin, J. Reckless, 2005, Journal of Vascular Research.

Lipoprotein(a) vascular accumulation in mice. In vivo analysis of the role of lysine binding sites using recombinant adenovirus.

E. Rubin, R. Lawn, D. Grainger, 1997, The Journal of clinical investigation.

Proliferation of human smooth muscle cells promoted by lipoprotein(a).

P. Weissberg, R. Lawn, D. Grainger, 1993, Science.

Tamoxifen decreases the rate of proliferation of rat vascular smooth-muscle cells in culture by inducing production of transforming growth factor beta.

P. Weissberg, D. Grainger, J. Metcalfe, 1993, The Biochemical journal.

Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms

N. Morrell, Jingxu Guo, D. Grainger, 2020, Nature Communications.

Identification of 3-(acylamino)azepan-2-ones as stable broad-spectrum chemokine inhibitors resistant to metabolism in vivo.

D. Grainger, I. Greig, D. Fox, 2005, Journal of medicinal chemistry.

Cloning and analysis of the promoter region of the rat SM22 alpha gene.

J. Osbourn, D. Grainger, J. Metcalfe, 1995, The Biochemical journal.

Cloning and analysis of the promoter region of the rat SM22α gene

J. Osbourn, D. Grainger, J. Metcalfe, 1995 .

Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors.

D. Grainger, Hannah Lingard, D. Fox, 2009, Journal of medicinal chemistry.

The pan‐chemokine inhibitor NR58‐3.14.3 abolishes tumour necrosis factor‐α accumulation and leucocyte recruitment induced by lipopolysaccharide in vivo

D. Grainger, J. Reckless, Lauren M. Tatalick, 2001, Immunology.

Metabonomics as a Tool for Understanding Lipid Metabolism

E. Holmes, D. Grainger, D. Mosedale, 2004 .

An antibody present in normal human serum inhibits the binding of cytokines to their receptors in an in vitro system.

D. Grainger, D. Mosedale, 1999, The Biochemical journal.

ID ‐ A dominant negative regulator of skeletal muscle differentiation — is not involved in maturation or differentiation of vascular smooth muscle cells

D. Grainger, J. Metcalfe, P. Kemp, 1995, FEBS letters.

Approaches to the development of selective inhibitors of vascular smooth muscle cell proliferation.

P. Weissberg, D. Grainger, C. Shanahan, 1993, Cardiovascular research.

A pivotal role for TGF-beta in atherogenesis?

D. Grainger, J. Metcalfe, 1995, Biological reviews of the Cambridge Philosophical Society.

ACTIVATION OF TRANSFORMING GROWTH-FACTOR-BETA IS INVERSELY CORRELATED WITH 3 MAJOR RISK-FACTORS FOR CORONARY-ARTERY DISEASE - LIPOPROTEIN(A), LDL-CHOLESTEROL AND PLASMINOGEN-ACTIVATOR INHIBITOR-1

D. Grainger, P. Schofield, J. Metcalfe, 1994 .

Metabolomics in coronary heart disease

D. Grainger, D. Mosedale, 2012 .

Adult human aortic smooth muscle cells in culture produce active TGF-beta.

P. Weissberg, D. Grainger, J. Metcalfe, 1993, The American journal of physiology.

Broad-spectrum chemokine inhibition ameliorates experimental obliterative bronchiolitis.

D. Grainger, E. Verrier, B. Naidu, 2003, The Annals of thoracic surgery.

A microtitre format assay for proline in human serum or plasma.

D. Grainger, S. Aitken, 2004, Clinica chimica acta; international journal of clinical chemistry.

Transforming growth factor-beta1 gene polymorphisms and coronary artery disease.

J. Gunn, J. Kaski, D. Crossman, 1998, Clinical science.

Blockade of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitro without blocking gp120/CCR5 interaction

D. Grainger, A. Lever, 2005, Retrovirology.

Proliferation of human aortic vascular smooth muscle cells in culture is modulated by active TGF beta.

P. Weissberg, D. Grainger, J. Metcalfe, 1995, Cardiovascular research.

Transforming growth factor beta decreases the rate of proliferation of rat vascular smooth muscle cells by extending the G2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase.

P. Weissberg, D. Grainger, J. Metcalfe, 1994, The Biochemical journal.

A new sensitive and specific enzyme-linked immunosorbent assay for IgD.

M. Sandhu, J. Luan, D. Grainger, 2006, Journal of immunological methods.

Transforming growth factor beta is sequestered into an inactive pool by lipoproteins.

C. Byrne, D. Grainger, J. Metcalfe, 1997, Journal of lipid research.

Heparin decreases the rate of proliferation of rat vascular smooth muscle cells by releasing transforming growth factor beta-like activity from serum.

P. Weissberg, D. Grainger, J. Watson, 1993, Cardiovascular research.

Cell volume and rate of proliferation, but not protein expression pattern, distinguish pup/intimal smooth muscle cells from subcultured adult smooth muscle cells

D. Grainger, E. McKilligin, 2001, Cell proliferation.

A pattern of anti-carbohydrate antibody responses present in patients with advanced atherosclerosis.

D. Grainger, P. Schofield, D. Mosedale, 2006, Journal of immunological methods.

Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone.

J. Compston, D. Grainger, S. Bord, 1996, Bone.

Preventive usage of broad spectrum chemokine inhibitor NR58-3.14.3 reduces the severity of pulmonary and hepatic graft-versus-host disease

E. Holler, R. Andreesen, D. Grainger, 2009, International journal of hematology.

TGF- in Atherosclerosis

D. Grainger, 2004 .

Transforming growth factor-b1 gene polymorphisms and coronary artery disease

J. Kaski, P. Syrris, D. Grainger, 1998 .

TGF-beta in blood: a complex problem.

D. Grainger, D. Mosedale, J. Metcalfe, 2000, Cytokine & growth factor reviews.

The Id gene is activated by serum but is not required for de-differentiation in rat vascular smooth muscle cells.

P. Weissberg, D. Grainger, C. Shanahan, 1991, The Biochemical journal.

Cultures of proliferating vascular smooth muscle cells from adult human aorta.

D. Grainger, J. Metcalfe, H. L. Kirschenlohr, 1996, Methods in molecular medicine.

Local anaesthesia for inguinal herniorrhaphy — a neglected technique

D. Grainger, M. Young, W. Humphries, 1994, Irish journal of medical science.

Release and activation of platelet latent TGF–β in blood clots during dissolution with plasmin

L. Wakefield, D. Grainger, H. Bethell, 1995, Nature Medicine.

TGF-β and the cardiovascular system

D. Grainger, D. Mosedale, 2001 .

Design, synthesis, and preliminary pharmacological evaluation of N-acyl-3-aminoglutarimides as broad-spectrum chemokine inhibitors in vitro and anti-inflammatory agents in vivo.

D. Grainger, D. Fox, J. Reckless, 2002, Journal of medicinal chemistry.

Quantitative analysis of a synthetic peptide, NR58-3.14.3, in serum by LC-MS with inclusion of a diastereomer as internal standard.

D. Grainger, D. Axworthy, L. Tatalick, 2000, Analytical biochemistry.

Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction.

C. Martyn, C. Gale, D. Grainger, 2005, Atherosclerosis.

TGF-β in blood: a complex problem

D. Grainger, D. Mosedale, J. Metcalfe, 2000 .

Mineral resources of Saudi Arabia : not including oil, natural gas, and sulfur

D. Grainger, P. Collenette, 1994 .

Metabolomic analysis of urine and serum in Parkinson’s disease

R. Barker, D. Grainger, D. Mosedale, 2008, Metabolomics.

Transforming growth factor

D. Grainger, D. Brann, K. Dhandapani, 2003 .

Broad-spectrum chemokine inhibitors (BSCIs) and their anti-inflammatory effects in vivo.

D. Grainger, J. Reckless, 2003, Biochemical pharmacology.

Formation of a functional morphogen gradient by a passive process in tissue from the early Xenopus embryo.

J. Gurdon, D. Grainger, D J Grainger, 2001, The International journal of developmental biology.

Genetic control of the circulating concentration of transforming growth factor type beta1.

T. Spector, H. Snieder, D. Grainger, 1999, Human molecular genetics.

TGF-β and atherosclerosis in man

D. Grainger, 2007 .

Sensitivity to Intravenous Anaesthetics: A Report of Three Cases

J. Sutton, J. Dundee, D. Grainger, 1974, British medical journal.

Reversal of neuromuscular block

J. Dundee, D. Grainger, I. Bali, 1983 .

Reversal of neuromuscular block. Heart rate changes with slow injection of neostigmine and atropine mixtures.

J. Dundee, D. Grainger, I. Bali, 1983, Anaesthesia.

A PIVOTAL ROLE FOR TGF‐β* IN ATHEROGENESIS?

D. Grainger, J. Metcalfe, 1995 .

Dietary fat and reduced levels of TGFbeta1 act synergistically to promote activation of the vascular endothelium and formation of lipid lesions.

D. Grainger, E. Böttinger, D. Mosedale, 2000, Journal of cell science.

Monocyte chemoattractant protein-1 but not tumor necrosis factor-alpha is correlated with monocyte infiltration in mouse lipid lesions.

E. Rubin, D. Grainger, J. Metcalfe, 1999, Circulation.

Novel broad-spectrum chemokine inhibitor protects against lung ischemia-reperfusion injury.

D. Grainger, E. Verrier, B. Naidu, 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension.

J. Nicholson, E. Holmes, D. Grainger, 2003, The Analyst.

Proteostasis is adaptive: Balancing chaperone holdases against foldases

K. Dill, D. Grainger, D. Mosedale, 2020, PLoS Comput. Biol..

Active and acid-activatable TGF-β in human sera, platelets and plasma

P. Weissberg, D. Grainger, D. Mosedale, 1995 .

Proposal of a novel diabetogenic mechanism involving the serpin PAI-1.

D. Grainger, S. L. Griffiths, 2006, BioEssays : news and reviews in molecular, cellular and developmental biology.

The Role of Serum TGF-β Isoforms as Potential Markers of Osteoporosis

T. Spector, D. Grainger, M. Chiano, 1999, Osteoporosis International.

The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis

A. Grace, R. Lawn, D. Grainger, 1995, Nature Medicine.

Thrombospondin 1 does not activate transforming growth factor beta1 in a chemically defined system or in smooth-muscle-cell cultures.

D. Grainger, E. Frow, 2000, The Biochemical journal.

The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro

D. Menon, D. Grainger, P. Mastroeni, 2007, Journal of Neuroimmunology.

Apolipoprotein E Modulates Clearance of Apoptotic Bodies In Vitro and In Vivo, Resulting in a Systemic Proinflammatory State in Apolipoprotein E-Deficient Mice1

D. Grainger, E. McKilligin, Elaine McKilligin, 2004, The Journal of Immunology.

State in Apolipoprotein E-Deficient Mice Resulting in a Systemic Proinflammatory Apoptotic Bodies In Vitro and In Vivo, Apolipoprotein E Modulates Clearance of

D. Grainger, E. McKilligin, J. Reckless, 2004 .

Proteomics, Metabolomics, and Immunomics on Microparticles Derived From Human Atherosclerotic Plaques

Manuel Mayr, John R Griffiths, Chantal M Boulanger, 2009, Circulation. Cardiovascular genetics.

Tools for anti‐inflammatory drug design: In vitro models of leukocyte migration

D. Grainger, E. Frow, J. Reckless, 2004, Medicinal research reviews.

Transforming growth factor-beta: the key to understanding lipoprotein(a)?

D. Grainger, J. Metcalfe, 1995, Current opinion in lipidology.

A Common Phenotype Associated with Atherogenesis in Diverse Mouse Models of Vascular Lipid Lesions

E. Rubin, D. Grainger, J. Metcalfe, 2001, Journal of Vascular Research.

Optimization of immunofluorescence methods by quantitative image analysis.

D. Grainger, D. Mosedale, D E Mosedale, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Chapter 12 – Metabolite Profiling and Cardiovascular Disease

D. Grainger, 2007 .

Human gene therapy: are we still expecting too much, too soon?

D. Grainger, 2001, QJM : monthly journal of the Association of Physicians.

Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms

N. Morrell, Jingxu Guo, D. Grainger, 2020, Nature Communications.

Metabolic profiling in heart disease

D. Grainger, M. DavidJ.Grainger, 2006 .

Metabonomics and Metabolomics

J. Nicholson, D. Grainger, 2006 .

Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines.

D. Grainger, J. Reckless, 1999, Biochemical Journal.

Hexamethylenebisacetamide selectively inhibits the proliferation of human and rat vascular smooth-muscle cells.

P. Weissberg, D. Grainger, J. Metcalfe, 1992, The Biochemical journal.

Transforming growth factor-beta dynamically regulates vascular smooth muscle differentiation in vivo.

D. Grainger, D. Mosedale, J. Metcalfe, 1998, Journal of cell science.

Active and acid-activatable TGF-beta in human sera, platelets and plasma.

P. Weissberg, D. Grainger, D. Mosedale, 1995, Clinica chimica acta; international journal of clinical chemistry.

Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

Henrik Antti, Jeremy K. Nicholson, Elaine Holmes, 2003, Nature Medicine.

Mitogens for adult rat aortic vascular smooth muscle cells in serum-free primary culture.

P. Weissberg, D. Grainger, J. Metcalfe, 1994, Cardiovascular research.

TGF-beta and atherosclerosis in man.

D. Grainger, 2007, Cardiovascular research.

Lithostratigraphy and Depositional History of Part of the Midyan Region, Northwestern Saudi Arabia

D. Grainger, G. Hughes, Abdul-Jaleel Abu-Bshait, 1999, GeoArabia.

Al Wahbah volcanic explosion crater, Saudi Arabia

D. Grainger, 1996 .

Tools for Antiinflammatory Drug Design: In vitro Models of Leukocyte Migration

D. Grainger, E. Frow, J. Reckless, 2004 .

Prevention et traitement de pathologies cardio-vasculaires au moyen d'analogues de tamoxifene

D. Grainger, R. Schroff, L. L. Kunz, 1996 .

A large accumulation of non-muscle myosin occurs at first entry into M phase in rat vascular smooth-muscle cells.

P. Weissberg, D. Grainger, J. Metcalfe, 1991, The Biochemical journal.

TGF-beta: implications for human vascular disease.

D. Grainger, J. Metcalfe, 1995, Journal of human hypertension.

When Worlds Collide: Autoimmunity and Atherosclerosis

D. Grainger, 2009, The Journal of Rheumatology.