D. Loskutoff

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Plasminogen activator inhibitors regulate cell adhesion through a uPAR‐dependent mechanism

R. Czekay, D. Loskutoff, 2009, Journal of cellular physiology.

Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease

D. Loskutoff, C. Dellas, Claudia Dellas, 2005, Thrombosis and Haemostasis.

Unexpected Role of Plasminogen Activator Inhibitor 1 in Cell Adhesion and Detachment

R. Czekay, D. Loskutoff, 2004, Experimental biology and medicine.

Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins

R. Czekay, K. Aertgeerts, D. Loskutoff, 2003, The Journal of cell biology.

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

D. Loskutoff, S. Rosenberg, S. Curriden, 1996, The Journal of cell biology.

Differential Regulation of Vitronectin in Mice and Humans in Vitro(*)

B. Binder, D. Loskutoff, S. Curriden, 1996, The Journal of Biological Chemistry.

Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator.

D. Loskutoff, C. Hekman, 1988, Archives of biochemistry and biophysics.

Binding of type 1 plasminogen activator inhibitor to the extracellular matrix of cultured bovine endothelial cells.

J. Mimuro, D. Loskutoff, 1989, The Journal of biological chemistry.

Interactions between fibrin and the plasminogen activators produced by cultured endothelial cells

D. Loskutoff, L. Mussoni, 1983 .

Localization of vitronectin in the normal and atherosclerotic human vessel wall

D. Loskutoff, D. Seiffert, B. V. van Aken, 1997, Histochemistry and Cell Biology.

Abnormalities in the Fibrinolytic System of the Vascular Wall Associated with Atherosclerosis

D. Loskutoff, D. Seiffert, B. Aken, 1994, Annals of the New York Academy of Sciences.

Distribution of vitronectin mRNA during murine development

M. Iruela-Arispe, E. Sage, D. Loskutoff, 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

Regulation of Vascular Fibrinolysis by Type 1 Plasminogen Activator Inhibitor

D. Loskutoff, D. Seiffert, B. V. Aken, 1995 .

Inhibitors of Urokinase and Thrombin in Cultured Neural Cells

S. Wagner, J. Mimuro, D. Loskutoff, 1991, Journal of neurochemistry.

Serum-derived vitronectin influences the pericellular distribution of type 1 plasminogen activator inhibitor

D. Loskutoff, D. Seiffert, N. Wagner, 1990, The Journal of cell biology.

Detection of Vitronectin by Ligand Blotting with Type 1 Plasminogen Activator Inhibitor

J. Mimuro, D. Loskutoff, D. Seiffert, 1990 .

Cultured granulosa cells produce two plasminogen activators and an antiactivator, each regulated differently by gonadotropins.

D. Loskutoff, A. Hsueh, T. Ny, 1985, Endocrinology.

Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1.

M. Gimbrone, D. Loskutoff, M. Bevilacqua, 1986, The Journal of clinical investigation.

Denaturant-induced stimulation of the beta-migrating plasminogen activator inhibitor in endothelial cells and serum.

D. Loskutoff, C. Hekman, L. Erickson, 1986, Blood.

Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor.

J. Mimuro, D. Loskutoff, R. Schleef, 1987, Blood.

Fibrinolytic Pathways and the Endothelium

D. Loskutoff, C. Hekman, Carla Hekman, 1987, Seminars in thrombosis and hemostasis.

Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries.

D. Loskutoff, R. Dilley, E. Bernstein, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Human Melanoma Cells Derived from Lymphatic Metastases Use Integrin aCv3 to Adhere to Lymph Node Vitronectin

D. Cheresh, J. Nip, D. Loskutoff, 2013 .

Elevated Expression of Transforming Growth Factor-β in Adipose Tissue from Obese Mice

D. Loskutoff, M. Pandey, K. Yamamoto, 1997 .

Type 1 plasminogen activator inhibitor gene expression following partial hepatectomy.

D. Loskutoff, J. Schneiderman, M. Sawdey, 1993, The American journal of pathology.

Human Endothelial Cells Produce IL‐6

T. Podor, F. Jirik, D. Loskutoff, 1989 .

Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals

K. Isobe, D. Loskutoff, Koji Yamamoto, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity.

S. Koschnick, D. Loskutoff, S. Konstantinides, 2001, The Journal of clinical investigation.

Plasminogen Activator Inhibitor-1 and Its Cofactor Vitronectin Stabilize Arterial Thrombi After Vascular Injury in Mice

D. Loskutoff, S. Konstantinides, K. Schäfer, 2001, Circulation.

The leptin receptor system of human platelets

R. Czekay, S. Koschnick, D. Loskutoff, 2005, Journal of thrombosis and haemostasis : JTH.

Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis

J. Ware, D. Loskutoff, Z. Ruggeri, 2006, Journal of thrombosis and haemostasis : JTH.

Tissue Distribution and Regulation of Plasminogen Activator Inhibitor-I in Obese Mice'

D. Loskutoff, F. Samad, 2007 .

Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide.

D. Loskutoff, K. Yamamoto, F. Samad, 1996, The Journal of clinical investigation.

Tissue Distribution and Regulation of Plasminogen Activator Inhibitor-1 in Obese Mice

D. Loskutoff, F. Samad, 1996, Molecular medicine.

Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis.

J. C. Torre, N. Mackman, D. Loskutoff, 1993, The Journal of clinical investigation.

Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells.

H. Moses, R. Raghow, J. Keski‐Oja, 1988, The Journal of biological chemistry.

Identification and regulation of tissue plasminogen activator activity in rat cumulus-oocyte complexes.

D. Sarkar, D. Loskutoff, A. Hsueh, 1986, Endocrinology.

Detection and partial characterization of an inhibitor of plasminogen activator in human platelets.

D. Loskutoff, M. Ginsberg, L. Erickson, 1984, The Journal of clinical investigation.

Expression of Transforming Growth Factor-β and Tumor Necrosis Factor-α in the Plasma and Tissues of Mice with Lupus Nephritis

D. Loskutoff, Koji Yamamoto, Koji Yamamoto, 2000, Laboratory Investigation.

Insulin Continues to Induce Plasminogen Activator Inhibitor 1 Gene Expression in Insulin-Resistant Mice and Adipocytes

D. Loskutoff, M. Pandey, F. Samad, 2000, Molecular medicine.

The Fat Mouse: A Powerful Genetic Model to Study Hemostatic Gene Expression in Obesity/NIDDM

D. Loskutoff, K. Fujisawa, F. Samad, 2000, Annals of the New York Academy of Sciences.

Regulation of Murine Protein C Gene Expression In Vivo: Effects of Tumor Necrosis Factor-α, Interleukin-1, and Transforming Growth Factor-β

H. Saito, D. Loskutoff, H. Saito, 1999, Thrombosis and Haemostasis.

Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter.

A. V. van Zonneveld, D. Loskutoff, S. Curriden, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of Two Monoclonal Antibodies Against Human Tissue-Type Plasminogen Activator

D. Loskutoff, R. Schleef, M. Sinha, 1985, Thrombosis and Haemostasis.

The fibrinolytic system of the vascular wall.

D. Loskutoff, T. Ny, R. Schleef, 1985, Clinics in haematology.

The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin

P. Carmeliet, J. Foidart, A. Noël, 2001, The Journal of cell biology.

Structural and Functional Analysis of the Plasminogen Activator Inhibitor-1 Binding Motif in the Somatomedin B Domain of Vitronectin*

D. Loskutoff, Soujuan Wang, K. Crain, 1996, The Journal of Biological Chemistry.

Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin.

D. Loskutoff, D. Seiffert, Dietmar Seiffert, 1991, The Journal of biological chemistry.

Endotoxin stimulates expression of the murine urokinase receptor gene in vivo.

D. Loskutoff, N. Varki, M. Sawdey, 1995, The American journal of pathology.

SPARC induces the expression of type 1 plasminogen activator inhibitor in cultured bovine aortic endothelial cells.

E. Sage, D. Loskutoff, P. Hasselaar, 1991, The Journal of biological chemistry.

Fibrinolytic system of vascular endothelial cells. Role of plasminogen activator inhibitors.

D. Loskutoff, R. Schleef, Raymond R. Schleef, 1988, Haemostasis.

Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin.

D. Cheresh, J. Nip, D. Loskutoff, 1992, The Journal of clinical investigation.

Leptin Promotes Vascular Remodeling and Neointimal Growth in Mice

D. Loskutoff, C. Dellas, M. Halle, 2004, Arteriosclerosis, thrombosis, and vascular biology.

The kidneys of mice with autoimmune disease acquire a hypofibrinolytic/procoagulant state that correlates with the development of glomerulonephritis and tissue microthrombosis.

D. Loskutoff, K. Yamamoto, Koji Yamamoto, 1997, The American journal of pathology.

Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity.

J. Griffin, Y. Sakata, D. Lawrence, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Expression of type 1 plasminogen activator inhibitor in renal tissue in murine lupus nephritis.

Y. Eguchi, D. Loskutoff, R. Burlingame, 1995, Kidney international.

The regulation of uterine tissue factor by estrogen

N. Mackman, S. Quirk, D. Loskutoff, 1995, Endocrine.

Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide

C. Fearns, D. Loskutoff, 1997, Infection and immunity.

Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo.

V. de Waard, C. Fearns, D. Loskutoff, 1998, Blood.

The adipocyte and hemostatic balance in obesity: studies of PAI-1.

D. Loskutoff, F. Samad, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction.

M. Hirai, M. Hayashi, T. Murohara, 2004, The American journal of pathology.

Increased Expression of Plasminogen Activator Inhibitor-1 with Fibrin Deposition in a Murine Model of Aging, "Klotho" Mouse

M. Hirai, Y. Nabeshima, T. Murohara, 2002, Seminars in Thrombosis and Hemostasis.

Renal expression of fibrinolytic genes and tissue factor in a murine model of renal disease as a function of age.

D. Loskutoff, H. Saito, K. Yamamoto, 1998, Seminars in thrombosis and hemostasis.

Regulation of tissue factor gene expression in obesity.

D. Loskutoff, M. Pandey, F. Samad, 2001, Blood.

Plasminogen activator inhibitor‐1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin

R. Czekay, D. Loskutoff, S. Curriden, 2001, Journal of cellular physiology.

Regulation of cell adhesion by PAI‐1

D. Loskutoff, S. Curriden, G. Deng, 1999, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Purification of a protein from bovine plasma that binds to type 1 plasminogen activator inhibitor and prevents its interaction with extracellular matrix. Evidence that the protein is vitronectin.

J. Mimuro, D. Loskutoff, 1989, Journal of Biological Chemistry.

Induction of plasminogen activator inhibitor‐1 (PAI‐1) gene expression in adipocytes by thiazolidinediones

D. Loskutoff, T. Urano, A. Takada, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Reverse fibrin autography: a method to detect and partially characterize protease inhibitors after sodium dodecyl sulfate--polyacrylamide gel electrophoresis.

D. Lawrence, D. Loskutoff, L. Erickson, 1984, Analytical biochemistry.

An Inhibitor Of Plasminogen Activator In Rabbit Endothelial Cells

D. Loskutoff, T. Edgington, Thomas J. Edgington, 1981, Thrombosis and Haemostasis.

Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin.

D. Loskutoff, D. Seiffert, 1991, Biochimica et biophysica acta.

Do PAI-1 and vitronectin promote or inhibit neointima formation? The exact role of the fibrinolytic system in vascular remodeling remains uncertain.

D. Loskutoff, S. Konstantinides, K. Schäfer, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Different Mechanisms of Increased Luminal Stenosis After Arterial Injury in Mice Deficient for Urokinase- or Tissue-Type Plasminogen Activator

G. Hasenfuss, D. Loskutoff, C. Dellas, 2002, Circulation.

Cellular localization of type 1 plasminogen activator inhibitor messenger RNA and protein in murine renal tissue.

Y. Eguchi, D. Loskutoff, M. Sawdey, 1993, The American journal of pathology.

The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related.

D. Loskutoff, C. Hekman, L. Erickson, 1985, Proceedings of the National Academy of Sciences of the United States of America.

The Fibrinolytic System of Cultured Endothelial Cells

D. Loskutoff, M. Sawdey, R. Schleef, 1987 .

Type 1 plasminogen activator inhibitor.

J. Mimuro, D. Loskutoff, M. Sawdey, 1989, Progress in hemostasis and thrombosis.

Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1.

K. Uysal, S. Wiesbrock, G. Hotamisligil, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Monocyte chemoattractant protein 1 in obesity and insulin resistance

D. Loskutoff, P. Sartipy, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide

C. Fearns, R. Ulevitch, V. Kravchenko, 1995, The Journal of experimental medicine.

Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.

T. Hirano, T. Podor, F. Jirik, 1989, Journal of immunology.

Tissue Distribution of Factor VIII Gene Expression In Vivo – A Closer Look

J. V. van Mourik, T. V. van Berkel, J. K. Kruijt, 2001, Thrombosis and Haemostasis.

Plasminogen Has a Broad Extrahepatic Distribution

D. Loskutoff, D. Seiffert, L. Miles, 2002, Thrombosis and Haemostasis.

Replication of dengue and junin viruses in cultured rabbit and human endothelial cells

A. Theofilopoulos, D. Loskutoff, C. Peters, 1978, Infection and immunity.

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

D. Loskutoff, C. Hekman, 1985, The Journal of biological chemistry.

Bovine plasminogen activator inhibitor 1: specificity determinations and comparison of the active, latent, and guanidine-activated forms.

D. Loskutoff, C. Hekman, 1988, Biochemistry.

Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.

D. Lawrence, J. V. van Mourik, D. Loskutoff, 1984, The Journal of biological chemistry.

Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

D. Lawrence, J. V. van Mourik, D. Loskutoff, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor.

J. Griffin, Y. Sakata, D. Loskutoff, 1986, Blood.

Comparative studies of the fibrinolytic activity of cultured vascular cells.

D. Loskutoff, E. Levin, 1979, Thrombosis research.

Carboxypeptidases: new regulators of plasminogen activation in vivo?

D. Loskutoff, 1995, The Journal of clinical investigation.

Inactivation of plasminogen activator inhibitor by oxidants.

D. Lawrence, D. Loskutoff, 1986, Biochemistry.

Critical Role of Integrin α5β1 in Urokinase (uPA)/Urokinase Receptor (uPAR, CD87) Signaling*

R. Czekay, A. Mazar, Y. Takada, 2003, Journal of Biological Chemistry.

Vitronectin gene expression in vivo. Evidence for extrahepatic synthesis and acute phase regulation.

D. Loskutoff, D. Seiffert, K. Crain, 1994, The Journal of biological chemistry.

Detection of vitronectin mRNA in tissues and cells of the mouse.

Y. Eguchi, D. Loskutoff, D. Seiffert, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Cultured bovine endothelial cells produce both urokinase and tissue- type plasminogen activators

D. Loskutoff, E. Levin, 1982, The Journal of cell biology.

Synthesis of a fibrinolytic activator and inhibitor by endothelial cells.

D. Loskutoff, T. Edgington, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Tissue factor expression during human and mouse development.

P. Carmeliet, T. Luther, S. Albrecht, 1996, The American journal of pathology.

Plasminogen activator inhibitors.

D. Loskutoff, J. Schneiderman, 1991, Trends in cardiovascular medicine.

Immunoradiometric assay to measure the binding of a specific inhibitor to tissue-type plasminogen activator.

D. Loskutoff, R. Schleef, M. Sinha, 1985, The Journal of laboratory and clinical medicine.

Activation of rabbit Hageman factor by homogenates of cultured rabbit endothelial cells.

J. Griffin, D. Loskutoff, T. Edgington, 1980, The Journal of clinical investigation.

Altered expression of plasminogen activator inhibitor type 1 in placentas from pregnant women with preeclampsia and/or intrauterine fetal growth retardation.

Y. Eguchi, J. Gilabert, A. Estellés, 1994, Blood.

Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator.

D. Loskutoff, K. Yamamoto, Koji Yamamoto, 1996, The Journal of clinical investigation.

Glomerular Extracellular Matrix Accumulation in Experimental Anti-GBM Ab Glomerulonephritis

D. Loskutoff, Winson W. Tang, Curtis B. Wilson, 2000, Nephron.

The PAI-1/Vitronectin Interaction: Two Cats in a Bag?

D. Loskutoff, D. Seiffert, G. Royle, 1995, Thrombosis and Haemostasis.

The Low Density Lipoprotein Receptor-related Protein Is a Motogenic Receptor for Plasminogen Activator Inhibitor-1*

R. Czekay, K. Aertgeerts, D. Loskutoff, 2004, Journal of Biological Chemistry.

Abnormal Expression of Type 1 Plasminogen Activator Inhibitor and Tissue Factor in Severe Preeclampsia

J. Gilabert, F. España, A. Estellés, 1998, Thrombosis and Haemostasis.

Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6.

T. Podor, F. Jirik, D. Loskutoff, 1989, Annals of the New York Academy of Sciences.

Activation of Hageman factor by cultured rabbit endothelial cells

R. Wiggins, D. Loskutoff, 1984 .

Glomerular tissue factor expression in crescentic glomerulonephritis. Correlations between antigen, activity, and mRNA.

P. Tipping, J. Erlich, D. Loskutoff, 1995, The American journal of pathology.

Enhanced Thrombosis in Atherosclerosis-Prone Mice Is Associated With Increased Arterial Expression of Plasminogen Activator Inhibitor-1

Emmanuelle M Mounier, D. Loskutoff, S. Konstantinides, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Effects of energy intake on type 1 plasminogen activator inhibitor levels in glomeruli of lupus-prone B/W mice.

D. Troyer, B. Chandrasekar, D. Loskutoff, 1995, The American journal of pathology.

A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor.

J. Griffin, B. Binder, D. Loskutoff, 1989, Blood.

Rapid, reversible rounding and aggregation of Rous sarcoma virus-infected chicken fibroblasts induced by a plasma macromolecule.

R. Weselake, D. Loskutoff, R. Mitchell, 1980, Cancer research.

Retinal pigment epithelial cells produce a latent fibrinolytic inhibitor that is antigenically and biochemically related to type 1 plasminogen activator inhibitor produced by vascular endothelial cells.

P. Campochiaro, J. Mimuro, D. Loskutoff, 1989, Experimental eye research.

[26] Plasminogen activators and their inhibitors

D. Loskutoff, R. Schleef, 1988 .

The Fibrinolytic System of Cultured Bovine Aortic Endothelial Cells

D. Loskutoff, 1987 .

Expression of plasminogen activator inhibitor type 2 in normal and psoriatic epidermis

P. Jensen, D. Loskutoff, G. Lazarus, 1994, Histochemistry.

Abnormal expression of plasminogen activator inhibitors in patients with gestational trophoblastic disease.

J. Gilabert, M. Chirivella, F. España, 1996, The American journal of pathology.

Analysis of PAI‐1 Gene Expression in Vivo Using in Situ Hybridization

D. Loskutoff, J. Schneiderman, M. Sawdey, 1994, Annals of the New York Academy of Sciences.

In situ hybridization: new approaches for the in vivo localization of fibrinolytic components

D. Loskutoff, D. Seiffert, 1993 .

Leptin signalling and leptin-mediated activation of human platelets: Importance of JAK2 and the phospholipases Cγ2 and A2

G. Hasenfuss, D. Loskutoff, C. Dellas, 2007, Thrombosis and Haemostasis.

Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse.

D. Loskutoff, M. Olman, K. Moser, 1995, The Journal of clinical investigation.

Platelets stimulate endothelial cells to synthesize type 1 plasminogen activator inhibitor. Evaluation of the role of transforming growth factor beta.

D. Loskutoff, S. Slivka, SR Slivka, 1991, Blood.

Regulation of Plasminogen Gene Expression

A. Gutiérrez-Fernández, D. Loskutoff, N. Gingles, 2003 .

Changes in the plasma levels of type 1 and type 2 plasminogen activator inhibitors in normal pregnancy and in patients with severe preeclampsia.

J. Gilabert, A. Estellés, D. Loskutoff, 1989, Blood.

Regulation of PAI-1 Gene Expression In Vivo

D. Loskutoff, J. Schneiderman, M. Sawdey, 1993, Thrombosis and Haemostasis.

Thrombotic phenotype of mice with a combined deficiency in plasminogen activator inhibitor 1 and vitronectin

S. Koschnick, D. Loskutoff, S. Konstantinides, 2005, Journal of thrombosis and haemostasis : JTH.

A slice of PAI.

D. Loskutoff, 1993, The Journal of clinical investigation.

Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alpha.

C. Fearns, D. Loskutoff, Colleen Fearns, 1997, The American journal of pathology.

Effect of Activated Protein C on the Fibrinolytic Components Released by Cultured Bovine Aortic Endothelial Cells

J. Griffin, Y. Sakata, D. Loskutoff, 1988 .

REGULATION OF PLASMINOGEN ACTIVATOR PRODUCTION BY CULTURED ENDOTHELIAL CELLS *

D. Loskutoff, E. Levin, 1982, Annals of the New York Academy of Sciences.

Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion.

D. Loskutoff, D. Seiffert, R. Dilley, 1995, The Journal of clinical investigation.

Medical control of abdominal aortic aneurysm expansion rate.

D. Loskutoff, D. Seiffert, R. Dilley, 1996, Journal of vascular surgery.

The fibrinolytic system of cultured endothelial cells: deciphering the balance between plasminogen activation and inhibition

D. Loskutoff, 1985 .

Fibrinolytic Components of Cultured Endothelial Cells

D. Loskutoff, L. Mussoni, E. Levin, 1982 .

Interactions between type 1 plasminogen activator inhibitor, extracellular matrix and vitronectin.

J. Mimuro, D. Loskutoff, D. Seiffert, 1990, Cell differentiation and development : the official journal of the International Society of Developmental Biologists.

Kinetic Analysis of the Interaction between Vitronectin and the Urokinase Receptor*

S. Futaki, Jieyi Wang, D. Loskutoff, 2002, The Journal of Biological Chemistry.

The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor.

B. Binder, D. Loskutoff, D. Seiffert, 1994, The Journal of biological chemistry.

Immunoelectron microscopic localization of type 1 plasminogen activator inhibitor on the surface of activated endothelial cells

T. Podor, D. Loskutoff, R. Schleef, 1991, The Journal of cell biology.

Type 1 Plasminogen Activator Inhibitor and Its Potential Influence on Thrombolytic Therapy

D. Loskutoff, 1988, Seminars in thrombosis and hemostasis.

Fibrinolytic System of Vascular Endothelial Cells

D. Loskutoff, R. Schleef, 1988 .

Interaction of type 1 plasminogen activator inhibitor with the enzymes of the contact activation system.

J. Griffin, F. España, D. Loskutoff, 1989, The Journal of biological chemistry.

Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling.

R. Czekay, A. Mazar, Y. Takada, 2003, The Journal of biological chemistry.

61 Elevated PAI-1 and tissue factor gene expression in obese mice: A possible mechanism for the increased risk for cardiovascular disease associated with obesity

D. Loskutoff, M. Pandey, V. D. Waard, 1997 .

Dysfunction of glomerular fibrinolysis in experimental antiglomerular basement membrane antibody glomerulonephritis.

L. Feng, D. Loskutoff, C. Wilson, 1993, Journal of the American Society of Nephrology : JASN.

Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1

K. Uysal, S. Wiesbrock, G. Hotamisligil, 1999 .

Gene Expression During the Development of Bacillus subtilis Bacteriophage φ29 II. Resolution of Viral-Specific Ribonucleic Acid Molecules

D. Loskutoff, J. J. Pène, 1973, Journal of virology.

Regulation of type 1 plasminogen activator inhibitor gene expression in cultured bovine aortic endothelial cells. Induction by transforming growth factor-beta, lipopolysaccharide, and tumor necrosis factor-alpha.

T. Podor, D. Loskutoff, M. Sawdey, 1989, The Journal of biological chemistry.

Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor.

M. Gimbrone, D. Loskutoff, M. Sawdey, 1988, The Journal of biological chemistry.

Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition.

P. Carmeliet, Hui Liao, D. Pinsky, 1998, The Journal of clinical investigation.

The Plasminogen Activator Inhibitor PAI-1 Controls In Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin: Implications for Antiangiogenic Strategies

Nils Brünner, Robert D. Gerard, Geert Carmeliet, 2001 .

Detection of both type 1 and type 2 plasminogen activator inhibitors in human cells

D. Loskutoff, R. Schleef, Nancy V. Wagner, 1988, Journal of cellular physiology.

Type 1 Plasminogen Activator Inhibitor Induces Multimerization of Plasma Vitronectin

D. Loskutoff, D. Seiffert, 1996, The Journal of Biological Chemistry.

Identification of the Disulfide Bonds in the Recombinant Somatomedin B Domain of Human Vitronectin*

D. Loskutoff, Y. Okumura, David J Loskutoff, 2002, The Journal of Biological Chemistry.

Effect of thrombin on the fibrinolytic activity of cultured bovine endothelial cells.

D. Loskutoff, 1979, The Journal of clinical investigation.

Extrahepatic expression and regulation of protein C in the mouse.

D. Loskutoff, K. Yamamoto, K. Yamamoto, 1998, The American journal of pathology.

Protein C inhibitor is expressed in tubular cells of human kidney.

J. Griffin, J. A. Fernandez, D. Loskutoff, 1994, The Journal of clinical investigation.

Effects of acidified fetal bovine serum on the fibrinolytic activity and growth of cells in culture

D. Loskutoff, 1978, Journal of cellular physiology.

Angiogenesis in an in vivo model of adipose tissue development

D. Loskutoff, J. Neels, T. Thinnes, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Characterization of a plasminogen activator secreted by cultured bovine aortic endothelial cells.

D. Loskutoff, K. Bykowska, D. Collen, 1982, Biochimica et biophysica acta.

Properties of plasminogen activators produced by endothelial cells

D. Loskutoff, E. Levin, 1984 .

Interactions between fibrin and the plasminogen activators produced by cultured endothelial cells.

D. Loskutoff, L. Mussoni, 1983, Blood.

A Direct, Plasmin Independent Assay For Plasminogen Activation

D. Lawrence, D. Loskutoff, L. Mussoni, 1984, Thrombosis and Haemostasis.

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct.

D. Rifkin, C. Metz, D. Loskutoff, 1994, Analytical biochemistry.

Urokinase-Type Plasminogen Activator Plays a Critical Role in Angiotensin II–Induced Abdominal Aortic Aneurysm

P. Carmeliet, M. Halks-Miller, D. Loskutoff, 2003, Circulation research.

Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis.

C. Barbas, D. Loskutoff, H. Pannekoek, 1993, Gene.

Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns.

D. Loskutoff, H. Pannekoek, J. Keijer, 1987, Biochemistry.

Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.

J. Millán, D. Lawrence, D. Loskutoff, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Expression Profiling Identifies Genes That Continue to Respond to Insulin in Adipocytes Made Insulin-resistant by Treatment with Tumor Necrosis Factor-α*

D. Loskutoff, P. Sartipy, 2003, Journal of Biological Chemistry.

Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.

A. V. van Zonneveld, D. Loskutoff, S. Curriden, 1991, The Journal of biological chemistry.

Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging.

K. Isobe, D. Loskutoff, Koji Yamamoto, 2002, The American journal of pathology.

Murine tissue factor gene expression in vivo. Tissue and cell specificity and regulation by lipopolysaccharide.

N. Mackman, D. Loskutoff, M. Sawdey, 1993, The American journal of pathology.

Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.

D. Loskutoff, M. Sawdey, S., 1991, The Journal of clinical investigation.

Domain 2 of the Urokinase Receptor Contains an Integrin-interacting Epitope with Intrinsic Signaling Activity

R. Czekay, F. Blasi, D. Loskutoff, 2005, Journal of Biological Chemistry.

Intracellular plasminogen activator activity in growing and quiescent cells

D. Loskutoff, David J. Loskutoff, D. Paul, 1978, Journal of cellular physiology.

The Role of Type 1 Plasminogen Activator Inhibitor in the Regulation of the Fibrinolytic System of the Normal and Atherosclerotic Vessel Wall

D. Loskutoff, D. Seiffert, 1991 .

Serum-mediated suppression of cell-associated plasminogen activator activity in cultured endothelial cells

D. Loskutoff, E. Levin, 1980, Cell.

PLASMINOGEN ACTIVATOR INHIBITOR

J. Mimuro, D. Loskutoff, C. Hekman, 1987, Thrombosis and Haemostasis.

Fibrinolytic system of cultured endothelial cells: Regulation by plasminogen activator inhibitor

D. Lawrence, D. Loskutoff, T. Ny, 1986, Journal of cellular biochemistry.

The Dexamethasone-Induced Inhibitor of Plasminogen Activator in Hepatoma Cells Is Antigenically-Related to an Inhibitor Produced by Bovine Aortic Endothelial Cells

D. Loskutoff, A. Huttenlocher, T. Gelehrter, 1986, Thrombosis and Haemostasis.

Molecular mechanisms of tumor necrosis factor‐α‐mediated plasminogen activator inhibitor‐1 expression in adipocytes

D. Loskutoff, M. Pandey, F. Samad, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Evidence that extrahepatic cells express vitronectin mRNA at rates approaching those of hepatocytes

D. Loskutoff, D. Seiffert, G. Bordin, 1996, Histochemistry and Cell Biology.

Regulation of type I plasminogen activator inhibitor synthesis by protein kinase C and cAMP in bovine aortic endothelial cells.

D. Loskutoff, S. Slivka, 1991, Biochimica et biophysica acta.

Gene Expression During the Development of Bacillus subtilis Bacteriophage φ29 I. Analysis of Viral-Specific Transcription by Deoxyribonucleic Acid-Ribonucleic Acid Competition Hybridization

D. Loskutoff, D. Andrews, J. J. Pène, 1973, Journal of virology.

Obesity enhances the induction of plasminogen activator inhibitor‐1 by restraint stress: a possible mechanism of stress‐induced renal fibrin deposition in obese mice

M. Hayashi, D. Loskutoff, J. Takamatsu, 2005, Journal of thrombosis and haemostasis : JTH.

Disruption of the plasminogen activator inhibitor‐1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice

D. Loskutoff, K. Schäfer, David J. Loskutoff, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Fibrinolytic System of the Vessel Wall and Its Role in the Control of Thrombosis

D. Loskutoff, S. Curriden, 1990, Annals of the New York Academy of Sciences.

functionally active type 1 plasminogen activator inhibitor Extracellular matrix of cultured bovine aortic endothelial cells contains

J. Mimuro, D. Loskutoff, R. Schleef, 2010 .

Human hepatoma cell line plasminogen activator.

D. Loskutoff, E. Levin, D. Fair, 1983, The Journal of laboratory and clinical medicine.

Inhibition of Endogenous Leptin Protects Mice From Arterial and Venous Thrombosis

D. Loskutoff, C. Dellas, Jaap G Neels, 2004, Arteriosclerosis, thrombosis, and vascular biology.

The majority of type 1 plasminogen activator inhibitor associated with cultured human endothelial cells is located under the cells and is accessible to solution-phase tissue-type plasminogen activator

J. Mimuro, T. Podor, D. Loskutoff, 1990, The Journal of cell biology.

Expression of type 1 plasminogen activator inhibitor in chronic pulmonary thromboemboli.

D. Loskutoff, M. Olman, K. Moser, 1994, Circulation.

Regulation of PAI-1 gene expression

D. Loskutoff, 1991 .

The Biochemistry, Cell and Molecular Biology of Type 1 Plasminogen Activator Inhibitor

D. Loskutoff, 1991 .

Messenger RNA for plasminogen activator inhibitor.

D. Loskutoff, T. Ny, M. Sawdey, 1986, Thrombosis research.

A Monoclonal Antibody that Does Not Recognize Tissue-Type Plasminogen Activator Bound to Its Naturally Occurring Inhibitor

D. Loskutoff, R. Schleef, Nancy V. Wagner, 1986, Thrombosis and Haemostasis.

Expression and cellular localization of messenger RNA for plasminogen activator inhibitor type 1 in human astrocytomas in vivo.

J. Bruner, G. Nicolson, S. Mohanam, 1994, Cancer research.

Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse.

K. Isobe, D. Loskutoff, Koji Yamamoto, 2002, Blood.

INTERLEUKIN 1 (IL-1) AND TUMOR NECROSIS FACTOR (TNF) ACTIVATION OF VASCULAR ENDOTHELIUM: EFFECTS ON PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) AND TISSUE-TYPE PLASMINOGEN ACTIVATOR (tPA)

D. Loskutoff, M. Sawdey, R. Schleef, 1987, Thrombosis and Haemostasis.

A method for defining binding sites involved in protein-protein interactions: analysis of the binding of plasminogen activator inhibitor 1 to the somatomedin domain of vitronectin.

D. Loskutoff, G. Deng, D. Seiffert, 2001, Analytical biochemistry.

Expression of Fibrinolytic Genes in Tissues from Human Atherosclerotic Aneurysms and from Obese Mice

D. Loskutoff, J. Schneiderman, F. Samad, 1997, Annals of the New York Academy of Sciences.

Abdominal Aortic Aneurysm Induced − Urokinase-Type Plasminogen Activator Plays a Critical Role in Angiotensin II

P. Carmeliet, M. Halks-Miller, D. Loskutoff, 2003 .

Tissue factor gene expression in the adipose tissues of obese mice.

D. Loskutoff, M. Pandey, F. Samad, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The fat mouse: a powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM.

D. Loskutoff, F. Samad, 1997, Thrombosis and haemostasis.

PAI-1, fibrosis, and the elusive provisional fibrin matrix.

D. Loskutoff, J. Quigley, James P. Quigley, 2000, The Journal of clinical investigation.

EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury.

J. Fallon, L. Campagnolo, S. Koschnick, 2005, The American journal of pathology.

in Human Platelets

D. Loskutoff, M. Ginsberg, L. Erickson, 1984 .

Patterns of expression of fibrinolytic genes and matrix metalloproteinase-9 in dissecting aortic aneurysms.

D. Loskutoff, D. Seiffert, R. Dilley, 1998, The American journal of pathology.

Plasminogen activator inhibitor-type I is a major biosynthetic product of retinal microvascular endothelial cells and pericytes in culture.

D. Loskutoff, A. Canfield, A. Schor, 1989, The Biochemical journal.

The Prothrombotic Effects of Leptin

D. Loskutoff, S. Konstantinides, K. Schäfer, 2001 .

The prothrombotic effects of leptin possible implications for the risk of cardiovascular disease in obesity.

D. Loskutoff, S. Konstantinides, K. Schafer, 2001, Annals of the New York Academy of Sciences.

Hemostatic Gene Expression and Vascular Disease in Obesity: Insights from Studies of Genetically Obese Mice

D. Loskutoff, F. Samad, 1999, Thrombosis and Haemostasis.

Distribution of Vitronectin mRNA During

M. Iruela-Arispe, E. Sage, D. Loskutoff, 1995 .

Immunoelectron Microscopic Localization of Type 1 Plasminogen Activator Inhibitor in the Extracellular Matrix of Transforming Growth Factor‐β‐Activated Endothelial Cells

T. Podor, D. Loskutoff, 1992, Annals of the New York Academy of Sciences.

PAI-1 inhibits neointimal formation after arterial injury in mice: a new target for controlling restenosis?

D. Loskutoff, 1997, Circulation.

Plasminogen activators and their inhibitors.

D. Loskutoff, R. Schleef, 1988, Methods in enzymology.

Elevated expression of transforming growth factor-beta in adipose tissue from obese mice.

D. Loskutoff, F. Samad, K Yamamoto, 1997, Molecular medicine.

Contribution of leptin receptor N-linked glycans to leptin binding.

D. Loskutoff, C. Dellas, J. Quigley, 2008, The Biochemical journal.

Scientific and Standardization Committee Communications Recommendations for the Nomenclature of Mutant Fibrinolytic Genes and Their Proteins

D. Loskutoff, H. Pannekoek, H. Lijnen, 1990, Thrombosis and Haemostasis.

Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin.

H. Scheraga, H. Dyson, S. Ołdziej, 2004, Biochemistry.