J. Florent

发表

Doxorubicin conjugates for selective delivery to tumors.

C. Monneret, J. Florent, Claude Monneret, 2008, Topics in current chemistry.

Synthesis of aryl phosphates based on pyrimidine and triazine scaffolds.

N. Gresh, J. Florent, C. Lenoir, 2010, European journal of medicinal chemistry.

Easy Access to Pyranoacridines, Pyranoxanthenes, and Arylchromenes Through a Domino Reaction

J. Florent, E. Bertounesque, C. Commandeur, 2011 .

Synthesis of 3-aryl-2-arylamidobenzofurans based on the Curtius rearrangement.

J. Florent, E. Bertounesque, P. Rousselle, 2011, The Journal of organic chemistry.

New anthracyclines synthesis: Electrical reduction, rate of glycoside elimination

C. Monneret, J. Florent, A. Anne, 1985 .

Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation.

C. Monneret, J. Florent, D. Carrez, 2006, Bioorganic & medicinal chemistry.

Expanding the chemical diversity of CK2 inhibitors

L. Mouawad, J. Florent, V. Moucadel, 2008, Molecular and Cellular Biochemistry.

Synthesis of globo- and isoglobotriosides bearing a cinnamoylphenyl tag as novel electrophilic thiol-specific carbohydrate reagents.

L. Johannes, J. Florent, Pascal Rochaix, 2006, Carbohydrate research.

Synthesis of Novel Angular Heterocyclic Lignans by an InCl3‐Catalyzed Friedel–Crafts‐Type Cyclization

C. Monneret, J. Florent, E. Bertounesque, 2008 .

A new drug-release method using the Staudinger ligation.

J. Florent, G. Tuffin, M. Azoulay, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of novel targeted pro-prodrugs of anthracyclines potentially activated by a monoclonal antibody galactosidase conjugate (part 1)

C. Monneret, J. Florent, P. Petit, 1992 .

Optimizing the formation of biocompatible gold nanorods for cancer research: functionalization, stabilization and purification.

J. Florent, Birgit Oberleitner, N. Bogliotti, 2011, Journal of colloid and interface science.

Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug.

L. Johannes, J. Florent, D. Decaudin, 2007, Angewandte Chemie.

Preparation and cytotoxic activity of some new rhodomycin derivatives bearing modifications in the sugar moiety.

A. Skaltsounis, J. Florent, P. Marakos, 2002, The Journal of antibiotics.

New Taxol (paclitaxel) prodrugs designed for ADEPT and PMT strategies in cancer chemotherapy.

C. Monneret, J. Florent, Frédéric Schmidt, 2006, Bioorganic & medicinal chemistry.

Synthesis of self-immolative glucuronide spacers based on aminomethylcarbamate. Application to 5-fluorouracil prodrugs for antibody-directed enzyme prodrug therapy

C. Monneret, J. Florent, Rachel Madec-Lougerstay, 1999 .

Direct in vivo observation of 5‐fluorouracil release from a prodrug in human tumors heterotransplanted in nude mice: a magnetic resonance study

C. Monneret, A. Volk, J. Florent, 2000, NMR in biomedicine.

Synthesis of self-immolative glucuronide-based prodrugs of a phenol mustard.

M. Poupon, C. Monneret, J. Florent, 1998, Anti-cancer drug design.

Prodrugs of anthracyclines for use in antibody-directed enzyme prodrug therapy.

C. Monneret, J. Florent, F. Tillequin, 1998, Journal of medicinal chemistry.

A new anthracycline with potent anti-leukemic activity overcomes P-glycoprotein multidrug resistance.

C. Monneret, J. Florent, J. Guillosson, 1998, Leukemia research.

2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology

M. Delepierre, L. Johannes, A. Houdusse, 2019, Chembiochem : a European journal of chemical biology.

Metal‐Free Activation of C(sp3)–H Bond, and a Practical and Rapid Synthesis of Privileged 1‐Substituted 1,2,3,4‐Tetrahydroisoquinolines

B. Parida, L. Johannes, J. Florent, 2017 .

Prodrugs of anthracycline antibiotics suited for tumor-specific activation.

C. Monneret, J. Florent, F. Tillequin, 1995, Anti-cancer drug design.

SYNTHESIS OF NEW GALACTOSYL AND LACTOSYL CARBAMATE-CONTAINING GLYCOLIPIDS

C. Monneret, J. Florent, V. Escriou, 2001 .

Synthesis of aminoglycal derivatives, precursors of glycosidic moieties of antitumor anthracyclines.

C. Monneret, J. Florent, J. Ughetto-Monfrin, 1988, Carbohydrate research.

Palladium-catalyzed domino C,N-coupling/carbonylation/Suzuki coupling reaction: an efficient synthesis of 2-aroyl-/heteroaroylindoles.

J. Florent, R. Pontikis, M. Arthuis, 2009, Organic letters.

Carbohydrate conformation and lipid condensation in monolayers containing glycosphingolipid Gb3: influence of acyl chain structure.

L. Johannes, J. Florent, Haifei Gao, 2014, Biophysical journal.

Synthesis and evaluation of new 2′,3′-dideoxynucleoside analogs as potential anti-AIDS and anti-herpes drugs

C. Monneret, J. Florent, D. Grierson, 1992 .

Synthesis of 1-(3-R-amino-4-hydroxy butyl)thymine acyclonucleoside. Analogs as potential anti-aids drugs

C. Monneret, J. Florent, D. Grierson, 1990 .

Targeted Shiga toxin-drug conjugates prepared via Cu-free click chemistry.

L. Johannes, J. Florent, Siau‐Kun Bai, 2015, Bioorganic & medicinal chemistry.

Design of selectively activated anticancer prodrugs: elimination and cyclization strategies.

J. Florent, F. Tillequin, S. Papot, 2002, Current medicinal chemistry. Anti-cancer agents.

Enhanced topoisomerase II-induced DNA breaks and free radical production by a new anthracycline with potent antileukemic activity.

C. Monneret, J. Florent, C. Auclair, 1996, Leukemia research.

A new acivicin prodrug designed for tumor-targeted delivery.

B. Bauvois, C. Monneret, C. Antczak, 2001, Bioorganic & medicinal chemistry.

NEW SYNTHETIC ROUTES FOR THE PREPARATION OF 2'-C-METHYLENE NUCLEOSIDES

C. Monneret, J. Florent, R. Pontikis, 1998 .

A new route to 2′-C-methylene nucleoside analogs, inhibitors of ribonucleotide reductase

C. Monneret, J. Florent, R. Pontikis, 1995 .

Synthesis of 3-aryl-2-arylamidobenzofurans based on the Curtius rearrangement.

J. Florent, E. Bertounesque, P. Rousselle, 2011, The Journal of organic chemistry.

Extensive characterization of sphere models established from colorectal cancer cell lines

A. Reyniès, A. Duval, A. Faussat, 2013, Cellular and Molecular Life Sciences.

Selective Palladium‐Catalyzed Direct Arylation of Furo[3,2‐b]pyridines

J. Florent, E. Bertounesque, P. Rousselle, 2012 .

Preparation and anti-HIV activity of N-3 amino substituted thymidine nucleoside analogs

E. Pacaud, C. Monneret, J. Florent, 1992 .

Shiga toxin induces tubular membrane invaginations for its uptake into cells

Katharina Gaus, Pierre Sens, Patricia Bassereau, 2007, Nature.

Nosiheptide, a sulfur-containing peptide antibiotic isolated fromStreptomyces actuosus 40037

R. Tissier, F. Benazet, J. Florent, 1980, Experientia.

Tandem Heck–Suzuki–Miyaura reaction: Application to the synthesis of constrained analogues of combretastatin A-4

J. Florent, R. Pontikis, M. Arthuis, 2007 .

Terminal alkyne-functionalized triazine by Sonogashira coupling: synthesis of a potential cell signalling inhibitor via click chemistry

N. Gresh, J. Florent, C. Garbay, 2008 .

A new access to 3-substituted-1(2H)-isoquinolone by tandem palladium-catalyzed intramolecular aminocarbonylation annulation.

J. Florent, M. Azoulay, Antoine Dieudonné-Vatran, 2012, Organic & biomolecular chemistry.

Palladium-catalyzed direct arylation of polysubstituted benzofurans.

J. Florent, E. Bertounesque, P. Rousselle, 2012, The Journal of organic chemistry.

Salicylaldehyde derivatives as new protein kinase CK2 inhibitors.

L. Mouawad, J. Florent, V. Moucadel, 2008, Biochimica et biophysica acta.

1-Aryltetralin privileged structure-based libraries: parallel synthesis of N-aryl and N-biaryl γ-lactam lignans

C. Monneret, J. Florent, E. Bertounesque, 2006 .

Anthracyclinones. 2. Isosaccharinic acid as chiral template for the synthesis of (+)-4-demethoxy-9-deacetyl-9-hydroxymethyldaunomycinone and (-)-4-deoxy-.gamma.-rhodomycinone

C. Monneret, J. Florent, J. Ughetto-Monfrin, 1987 .

BENA435, a new cell-permeant photoactivated green fluorescent DNA probe

C. Nguyen, J. Florent, D. Grierson, 2006, Nucleic acids research.

Stereoselective synthesis of novel highly substituted isochromanone and isoquinolinone-containing exocyclic tetrasubstituted alkenes.

J. Florent, R. Pontikis, M. Arthuis, 2009, The Journal of organic chemistry.

Synthesis of 3'-substituted-2',3'-dideoxynucleoside analogs as potential anti-aids drugs

C. Monneret, J. Florent, D. Grierson, 1989 .

An efficient synthesis of 1-cyano-2,3-unsaturated sugars via the reaction of glycals with Et2AlCN

C. Monneret, J. Florent, D. Grierson, 1984 .

Total synthesis of (s)-(-) and (r)-(+)-frontalin and of (-)-malyngolide from the branched-chain sugar “α”-d-isosaccharino-lactone as chiral template

C. Monneret, J. Florent, Minh-Chau Trinh, 1988 .

Enantioselective synthesis of the carbocyclic moiety of (−)-carbovir

C. Monneret, J. Florent, E. Roulland, 2003 .

Synthesis of chiral 4-alkyl 4-hydroxy cyclopentenones via a diastereoselective tandem aza-Cope/Mannich cyclization reaction from aldehydosugar

A. Skaltsounis, J. Florent, Cyrille Kuhn, 1995 .

Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues.

D. Scherman, J. Florent, G. Chabot, 2011, European journal of medicinal chemistry.

Synthetic approach to condensed heterocyclic analogues from etoposide revisited. Synthesis of A-ring pyridazine etoposide

C. Monneret, J. Florent, E. Bertounesque, 2007 .

Anthracyclinone. 3. Chiral pool synthesis of anthracyclinones via tetralin intermediates

C. Monneret, J. Florent, A. Génot, 1987 .

Determination of the anomeric configuration of 1-cyano-δ2,3-unsaturated sugars from JC(1)-H coupling values

C. Monneret, J. Florent, D. Grierson, 1990 .

Anthracyclinones. Enantioselective synthesis of 9-alkyanthracyclinone via highly diastereocontrolled alkylation of 4-cyanofuranosugars

C. Monneret, J. Florent, A. Cousson, 1993 .

p-NITROPHENYL -D-GLUCOPYRANOSIDURONIC ANALOGS AS POTENTIAL SUBSTRATES FOR -GLUCURONIDASE

C. Monneret, J. Florent, M. Azoulay, 1997 .

Azaindole derivatives are inhibitors of microtubule dynamics, with anti‐cancer and anti‐angiogenic activities

Laurence Lafanechère, Caroline Barette, Anne Martinez, 2013, British journal of pharmacology.

Chiral pool synthesis of tetralin as AB ring segment, precursor of anthracyclines.

C. Monneret, J. Florent, A. Génot, 1986 .

Protecting groups for glucuronic acid: application to the synthesis of new paclitaxel (taxol) derivatives.

C. Monneret, J. Florent, Frédéric Schmidt, 2006, The Journal of organic chemistry.

Synthesis and biological evaluation of new cross-conjugated dienone marine prostanoid analogues.

J. Madelmont, C. Monneret, J. Florent, 2004, Organic & biomolecular chemistry.

New 2'-C-branched-chain sugar nucleoside analogs with potential antiviral or antitumor activity

C. Monneret, J. Florent, D. Grierson, 1992 .

Anthracyclinones. 5. Glucosaccharino-1,4-lactone as a chiral template for the synthesis of new anthracyclinones

C. Monneret, J. Florent, B. Deguin, 1991 .

Regioselective Alkylation and Acylation of Methyl, 2,6-Dideoxyhexo-Pyranosides Via Their Stannylene Acetals: Key Step for the Synthesis of Daunosamine and Related Amino-Sugars

C. Monneret, J. Florent, R. Gagnet, 1987 .

Emericid, a new polyether antibiotic fromStreptomyces hygroscopicus (DS 24 367)

J. Florent, L. Ninet, J. Lunel, 1976, Experientia.

Synthesis of A Novel Sialyl Lewis X Analogue Containing A Pyrrolidine in Place of N-Acetyl Glucosamine

P. Savy, C. Monneret, J. Florent, 2000 .

Mechanism of Shiga Toxin Clustering on Membranes

J. Shillcock, L. Johannes, P. Bassereau, 2016, ACS nano.

Flambamycin, a new antibiotic fromStreptomyces hygroscopicus DS 23 230

J. Florent, L. Ninet, J. Lunel, 1974, Experientia.

Stereospecific synthesis of methyl 2,6-diacetamido-2,3,6-trideoxy-α-D-ribohexofuranoside and hexopyranoside, derivatives of tobrosamine

C. Monneret, J. Florent, 1981 .

Synthesis of cyclophosphamide analogs from aminotrideoxy sugars.

C. Monneret, J. Florent, R. Gagnet, 1993, Carbohydrate Research.

Synthesis of furo[2,3-c]pyran-β-D-thymidine

J. Florent, I. Bousquié, Valerie Madiot, 1996 .

Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs.

C. Monneret, J. Florent, D. Adams, 1997, Journal of medicinal chemistry.

Synthesis of acyclic analogs of azido-thymidine, amino-thymidine, and related nucleosides

C. Monneret, J. Florent, D. Grierson, 1991 .

Synthesis and biological evaluation of enantiomerically pure cyclopropyl analogues of combretastatin A4.

J. Florent, G. Chabot, S. Bourg, 2013, Bioorganic & medicinal chemistry.

Synthesis and Structure–Activity Relationships of Constrained Heterocyclic Analogues of Combretastatin A4

J. Florent, L. Morin-Allory, J. Seguin, 2011, ChemMedChem.

Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives.

C. Monneret, J. Florent, J. Kaffy, 2005, Organic & biomolecular chemistry.

Anthracyclinones VI. Diastereoselective synthesis of 7,10-dihydroxy-4-demethoxy-anthracyclinones☆

C. Monneret, J. Florent, E. Bertounesque, 1990 .

Chapter 15 – Vitamin B12

J. Florent, L. Ninet, 1979 .

Shiga toxin induces lipid compression: a mechanism for generating membrane curvature.

L. Johannes, J. Florent, J. Majewski, 2019, Nano letters.

Metal-Free Activation of a C(sp)-H Bond of Aryl Acetylenes.

B. Parida, L. Johannes, J. Florent, 2016, Chemistry.

Synthesis of (–)-frontalin from α-D-isosaccharino-1,4-lactone

C. Monneret, J. Florent, Minh-Chau Trinh, 1987 .

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

S. Knapp, L. Mouawad, A. Bullock, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2.

C. Nguyen, J. Florent, V. Moucadel, 2010, Cancer research.

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.

S. Knapp, A. di Pietro, C. Nguyen, 2012, Cancer research.

A rapid access to chiral alkylidene cyclopentenone prostaglandins involving ring-closing metathesis reaction

C. Monneret, J. Florent, E. Roulland, 2003 .

A Short and High Yield Access to Glycosyl Donors of Amino-Deoxy-Sugars of Biological Relevance

C. Monneret, J. Florent, F. Tillequin, 1998 .

Pharmacological and physicochemical properties of a new anthracycline with potent antileukemic activity.

C. Monneret, J. Florent, C. Auclair, 1991, Leukemia research.

Synthesis and antitumor activity of new anthracyclines.

C. Monneret, J. Florent, A. Génot, 1989, The Journal of antibiotics.

Stereocontrolled route to 3-amino-2,3,6-trideoxy-hexopyranoses. K-10 Montmorillonite as a glycosidation reagent for acosaminide synthesis

C. Monneret, J. Florent, 1987 .

Stereocontrolled Route to 3-Amino-2,3,6-trideoxy-hexopyranoses. K-10 Montmorillonite as a Glycosidation Reagent for Acosaminide Synthesis.

C. Monneret, J. Florent, 1988 .

Mechanism of the eletrochemical reduction of hydroxyiminoanthraquinones in DMF

J. Florent, C. Amatore, A. Anne, 1986 .

Addition of hydrazoique acid to pseudoglycals steroselective synthesis of L-acosamine and L-daunosamine

C. Monneret, J. Florent, B. Abbaci, 1989 .

SNAP‐tag Based Proteomics Approach for the Study of the Retrograde Route

L. Johannes, J. Florent, D. Loew, 2012, Traffic.

Chemistry‐based protein modification strategy for endocytic pathway analysis

L. Johannes, O. Melnyk, H. Drobecq, 2010, Biology of the cell.

[Small compounds libraries: a research tool for chemical biology].

J. Florent, 2013, Biologie aujourd'hui.

Synthesis and biological evaluation of cis-locked vinylogous combretastatin-A4 analogues: derivatives with a cyclopropyl-vinyl or a cyclopropyl-amide bridge.

J. Florent, A. Arrault, L. Morin-Allory, 2009, Bioorganic & medicinal chemistry letters.

Double-Stranded Ribonucleic Acid from Mengo Virus: Production, Characterization, and Interferon-Inducing and Antiviral Activities in Comparison with Polyriboinosinic · Polyribocytidylic Acid

J. Florent, R. Falcoff, E. Falcoff, 1973, Antimicrobial Agents and Chemotherapy.

Double-Stranded Ribonucleic AcidfromMengo Virus: Production, Characterization , and

J. Florent, E. Falcoff, L. Ninet, 1973 .

AN EFFICIENT SYNTHESIS OF OPTICALLY ACTIVE 4-DEMETHOXYANTHRACYCLINONES

C. Monneret, J. Florent, F. Bennani, 1985 .

Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (ADEPT) : A phenol nitrogen mustard carbamate

C. Monneret, J. Florent, M. Gerken, 1997 .

A General and Convenient Photochemical Method for the Preparation of Deoxysugars

C. Monneret, J. Florent, C. Portella, 1977 .

TOTAL SYNTHESIS OF 4-DEMETHOXYFEUDOMYCINONE C

C. Monneret, J. Florent, E. Bertounesque, 1991 .

Synthesis and Properties of a Mitochondrial Peripheral Benzodiazepine Receptor Conjugate

L. Johannes, J. Florent, D. Decaudin, 2008, ChemMedChem.

Direct in vivo observation of 5‐fluorouracil release from a prodrug in human tumors heterotransplanted in nude mice: a magnetic resonance study

C. Monneret, A. Volk, J. Florent, 2000, NMR in biomedicine.

[Small compounds libraries: a research tool for chemical biology].

J. Florent, 2013, Biologie aujourd'hui.

Synthesis of 11-Methoxy Anthracyclines

C. Monneret, J. Florent, A. Génot, 1991 .

An efficient synthesis of optically active 4-demethoxy anthracyclinones

C. Monneret, J. Florent, Fatima Bennani, 1984 .

Carbohydrate conformation and lipid condensation in monolayers containing glycosphingolipid Gb3: influence of acyl chain structure.

L. Johannes, J. Florent, Haifei Gao, 2014, Biophysical journal.

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

S. Knapp, L. Mouawad, A. Bullock, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

2-Nitro and 4-nitro-quinone-methides are not irreversible inhibitors of bovine beta-glucuronidase.

C. Monneret, J. Florent, J. Gesson, 2001, Carbohydrate Research.

2-Nitro and 4-Nitro-quinone-methides Are not Irreversible Inhibitors of Bovine β-Glucuronidase.

C. Monneret, J. Florent, J. Gesson, 2001 .

Tandem Heck—Suzuki—Miyaura Reaction: Application to the Synthesis of Constrained Analogues of Combretastatin A‐4.

J. Florent, R. Pontikis, M. Arthuis, 2007 .

Synthesis and reactions of derivatives of 1,7-dioxaspiro[5.5]undec-2-en-4-one

A. Barrett, J. Florent, M. Finch, 1986 .

Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues.

D. Scherman, J. Florent, G. Chabot, 2011, European journal of medicinal chemistry.