J. Nishioka

发表

Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma

T. Wakita, Tatsuya Hayashi, J. Nishioka, 2004, International journal of cancer.

Methylthioadenosine phosphorylase gene is silenced by promoter hypermethylation in human lymphoma cell line DHL-9: another mechanism of enzyme deficiency.

M. Kusunoki, Yasuaki Yamada, S. Kamihira, 2005, International journal of oncology.

Elevated Levels of Prothrombin Fragment 1 + 2 Indicate High Risk of Thrombosis

A. Sudo, A. Uchida, Y. Abe, 2008, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

A novel role for Notch ligand Delta‐1 as a regulator of human Langerhans cell development from blood monocytes

J. Nishioka, H. Shiku, K. Nakatani, 2005, Journal of leukocyte biology.

Functionally active thrombomodulin is present in human platelets.

Tatsuya Hayashi, J. Nishioka, T. Hayashi, 1988, Journal of biochemistry.

A domain composed of epidermal growth factor-like structures of human thrombomodulin is essential for thrombin binding and for protein C activation.

S. Yamamoto, Tatsuya Hayashi, J. Nishioka, 1989, The Journal of biological chemistry.

Protein C inhibitor inhibits breast cancer cell growth, metastasis and angiogenesis independently of its protease inhibitory activity

A. Uchida, Tatsuya Hayashi, J. Nishioka, 2007, International journal of cancer.

Protein C inhibitor regulates hepatocyte growth factor activator-mediated liver regeneration in mice

S. Uemoto, T. Hamada, Tatsuya Hayashi, 2007, Gut.

Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions

Tatsuya Hayashi, J. Nishioka, K. Asanuma, 2004, Journal of thrombosis and haemostasis : JTH.

Measurement of protein C inhibitor in seminal plasma is useful for detecting agenesis of seminal vesicles or the vas deferens.

J. Nishioka, J. Kawamura, K. Suzuki, 2000, Journal of andrology.

Molecular cloning, tissue distribution and androgen regulation of rat protein C inhibitor

T. Wakita, Tatsuya Hayashi, J. Nishioka, 1998, FEBS letters.

Protein C Inhibitor Secreted from Activated Platelets Efficiently Inhibits Activated Protein C on Phosphatidylethanolamine of Platelet Membrane and Microvesicles*

Tatsuya Hayashi, J. Nishioka, Koji Suzuki, 1998, The Journal of Biological Chemistry.

Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor.

J. Nishioka, J. Kawamura, K. Suzuki, 1996, European journal of biochemistry.

Frequency of Abnormal Biphasic aPTT Clot Waveforms in Patients with Underlying Disorders Associated with Disseminated Intravascular Coagulation

Y. Abe, J. Nishioka, H. Shiku, 2006, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

Increased activated protein C-protein C inhibitor complex levels in patients with pulmonary embolism.

J. Nishioka, H. Wada, T. Hayashi, 1994, Thrombosis and haemostasis.

Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells.

Tatsuo Itakura, Y. Abe, J. Nishioka, 2004, International journal of oncology.

A case of thrombomodulin mutation causing defective thrombin binding with absence of protein C and TAFI activation.

Tatsuya Hayashi, J. Nishioka, N. Akita, 2020, Blood advances.

Plasma levels of activated protein C–protein C inhibitor complex in patients with hypercoagulable states

J. Nishioka, E. Gabazza, Koji Suzuki, 2000, American journal of hematology.

Association of epidermal growth factor receptor mutations in lung cancer with chemosensitivity to gefitinib in isolated cancer cells from Japanese patients.

J. Nishioka, K. Noma, K. Nakatani, 2007, European journal of cancer care.

Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma.

J. Nishioka, I. Yada, T. Nobori, 2009, Lung cancer.

Haemostatic abnormalities and thrombotic disorders in malignant lymphoma

Y. Abe, J. Nishioka, H. Shiku, 2004, Thrombosis and Haemostasis.

Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects.

J. Nishioka, K. Nakatani, T. Nobori, 2005, International journal of molecular medicine.

Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily.

K. Kurachi, S. Yamamoto, J. Nishioka, 1987, The Journal of biological chemistry.

Mechanism of inhibition of activated protein C by protein C inhibitor.

J. Nishioka, K. Suzuki, S. Hashimoto, 1984, Journal of biochemistry.

Protein C anticoagulant system in patients with interstitial lung disease.

J. Nishioka, E. Gabazza, H. Wada, 1998, American journal of respiratory and critical care medicine.

Tissue factor messenger RNA levels in leukocytes compared with tissue factor antigens in plasma from patients in hypercoagulable state caused by various diseases

Y. Abe, J. Nishioka, H. Shiku, 2004, Thrombosis and Haemostasis.

Diagnosis of deep vein thrombosis by plasma‐soluble fibrin or D‐dimer

Y. Abe, T. Nakano, J. Nishioka, 2005, American journal of hematology.

Neurotrophic receptor tyrosine kinase B induces c-fos-associated cell survival.

J. Nishioka, K. Nakatani, T. Nobori, 2009, International journal of molecular medicine.

Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats -- a possible mechanism of intrasinusoidal microthrombus formation and liver dysfunction.

Tatsuya Hayashi, J. Nishioka, E. Gabazza, 2003, Journal of hepatology.

Hereditary Thrombophilia Caused by Abnormality of the Anticoagulant Protein C Pathway: Prenatal Diagnosis of Compound Heterozygous Protein C Deficiency by Direct Detection of the Mutation Sites

Tatsuya Hayashi, J. Nishioka, M. Ido, 1999 .

Primary structure of vitamin K-dependent human protein Z.

J. Nishioka, Y. Deyashiki, T. Hayashi, 1990, Biochemical and biophysical research communications.

Usefulness of Measurement of Reticulated Platelets for Diagnosis of Idiopathic Thrombocytopenic Purpura

Y. Abe, J. Nishioka, H. Shiku, 2005, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

Usefulness of Fully Automated Measurement of Reticulated Platelets Using Whole Blood

Y. Abe, J. Nishioka, H. Shiku, 2005, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay

A. Yu, Yasuaki Yamada, J. Nishioka, 2000, Leukemia.

Elevated levels of leukocyte tissue factor mRNA in patients with venous thromboembolism.

Y. Abe, T. Nakano, J. Nishioka, 2005, Thrombosis research.

Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va.

J. Nishioka, M. Matsuda, K. Suzuki, 1984, Journal of biochemistry.

β2-Glycoprotein I Modulates the Anticoagulant Activity of Activated Protein C on the Phospholipid Surface

J. Nishioka, E. Gabazza, Koji Suzuki, 1996, Thrombosis and Haemostasis.

A thrombin-based peptide corresponding to the sequence of the thrombomodulin-binding site blocks the procoagulant activities of thrombin.

J. Nishioka, K. Suzuki, 1991, The Journal of biological chemistry.

Localization of thrombomodulin-binding site within human thrombin.

J. Nishioka, T. Hayashi, K. Suzuki, 1990, The Journal of biological chemistry.

Monitoring peripheral blood CD4+ adenosine triphosphate activity after living donor liver transplantation: impact of combination assays of immune function and CYP3A5 genotype

T. Hamada, J. Nishioka, M. Okuda, 2011, Journal of hepato-biliary-pancreatic sciences.

Notch ligand Delta‐1 differentially modulates the effects of gp130 activation on interleukin‐6 receptor α‐positive and ‐negative human hematopoietic progenitors

Y. Sugimoto, T. Nakahata, J. Nishioka, 2007, Cancer science.

Flow cytometric analysis of IL‐6 receptors on peripheral lymphocytes in patients with primary biliary cirrhosis

J. Nishioka, Kojiro Takase, M. Kaito, 1998, Journal of clinical laboratory analysis.

EFFICACY OF PROCALCITONIN IN THE EARLY DIAGNOSIS OF BACTERIAL INFECTIONS IN A CRITICAL CARE UNIT

J. Nishioka, M. Ikejiri, T. Nobori, 2008, Shock.

Identical binding site on human platelets for von Willebrand factor and bovine platelet aggregating factor.

J. Nishioka, K. Suzuki, S. Hashimoto, 1980, Thrombosis research.

Hemostatic abnormalities and leukocyte activation caused by infection in patients with malignant lymphoma during chemotherapy.

Y. Abe, J. Nishioka, H. Shiku, 2006, Thrombosis research.

Protein C Inhibitor: Structure and Function

J. Nishioka, Koji Suzuki, K. Toma, 1989, Thrombosis and Haemostasis.

The Effectiveness of Measuring for Fragmented Red Cells Using an Automated Hematology Analyzer in Patients With Thrombotic Microangiopathy

Y. Abe, J. Nishioka, M. Ikejiri, 2009, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

S. Yamamoto, I. Maruyama, J. Nishioka, 1987, The EMBO journal.

Regulation of activated protein C by thrombin-modified protein S.

J. Nishioka, K. Suzuki, S. Hashimoto, 1983, Journal of biochemistry.

Vancomycin as well as ristocetin facilitates von Willebrand factor binding to platelets.

J. Nishioka, K. Suzuki, S. Hashimoto, 1980, Thrombosis research.

A simple technique for purification of fibrinogen from plasma by affinity chromatography on ristocetin-agarose.

J. Nishioka, K. Suzuki, S. Hashimoto, 1980, Thrombosis research.

The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor.

J. Nishioka, K. Suzuki, S. Hashimoto, 1980, Thrombosis research.

Host protein C inhibitor inhibits tumor growth, but promotes tumor metastasis, which is closely correlated with hypercoagulability.

M. Shimaoka, Tatsuya Hayashi, J. Nishioka, 2015, Thrombosis research.

Protein C inhibitor. Purification from human plasma and characterization.

J. Nishioka, K. Suzuki, S. Hashimoto, 1983, The Journal of biological chemistry.

Normal function levels of protein C inhibitor in two groups with different inheritance modes of congenital combined factor V/VIII deficiency

J. Nishioka, Koji Suzuki, J. Takamatsu, 1984 .

Multicenter evaluation of prototype real‐time PCR assays for Epstein‐Barr virus and cytomegalovirus DNA in whole blood samples from transplant recipients

S. Ichiyama, J. Nishioka, Y. Ando, 2010, Microbiology and immunology.

Differential regulation of protein S expression in hepatocytes and sinusoidal endothelial cells in rats with cirrhosis

S. Uemoto, Tatsuya Hayashi, J. Nishioka, 2006, Journal of thrombosis and haemostasis : JTH.

Personalized treatment in the eradication therapy for Helicobacter pylori.

J. Nishioka, K. Nakatani, T. Nobori, 2011, International journal of molecular medicine.

PCR-Mediated Early Diagnosis of Fungal infections in Patients with Living-Donor Liver Transplants

J. Nishioka, T. Nobori, H. Wada, 2009 .

The interaction among protein C inhibitor, prostate-specific antigen, and the semenogelin system.

Tatsuya Hayashi, J. Nishioka, Koji Suzuki, 2007, Seminars in thrombosis and hemostasis.

Innate immune activation and antitumor effects of Lactobacillus-fermented Sparassis crispa extract in mice

J. Nishioka, Koji Suzuki, K. Hiramoto, 2020 .

Mushroom Sparassis crispa (Hanabiratake) fermented with lactic acid bacteria significantly enhances innate immunity of mice.

J. Nishioka, Koji Suzuki, K. Hiramoto, 2020, Biological & pharmaceutical bulletin.

Neurotrophic receptor, tropomyosin‐related kinase B as an independent prognostic marker in gastric cancer patients

Koji Tanaka, Y. Mohri, H. Tonouchi, 2009, Journal of surgical oncology.

Mitotic Checkpoint Protein hsMAD2 as a Marker Predicting Liver Metastasis of Human Gastric Cancers

C. Miki, M. Kusunoki, J. Nishioka, 2001, Japanese journal of cancer research : Gann.

Methylthioadenosine phosphorylase deficiency in Japanese osteosarcoma patients.

A. Uchida, A. Matsumine, J. Nishioka, 2007, International journal of oncology.

Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor)/NF-Y (nuclear factor-Y).

J. Nishioka, T. Fujikawa, K. Nakatani, 2005, The Biochemical journal.

Deletion of Dinucleotide Repeat (Δ14 Allele) in the Methylthioadenosine Phosphorylase (MTAP) Promoter and the Allelotype of MTAP Promoter in the Japanese Population

J. Nishioka, K. Nakatani, Yuwaraj Kadariya, 2002, Japanese journal of cancer research : Gann.

A simple technique to determine thrombopoiesis level using immature platelet fraction (IPF).

Y. Abe, J. Nishioka, K. Nakatani, 2006, Thrombosis research.

Molecular mechanism of the dysfunction of protein S(Tokushima) (Lys155-->Glu) for the regulation of the blood coagulation system.

J. Nishioka, T. Hayashi, K. Suzuki, 1995, Biochimica et biophysica acta.

Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S.

Tatsuya Hayashi, J. Nishioka, T. Hayashi, 1994, Blood.

Neurotrophic receptor, tropomyosin-related kinase B, as a chemoresistant marker in oesophageal cancer.

Y. Mohri, H. Tonouchi, C. Miki, 2009, Clinical oncology (Royal College of Radiologists (Great Britain)).

Biosynthesis and secretion of functional protein S by a human megakaryoblastic cell line (MEG-01)

M. Ogura, J. Nishioka, Koji Suzuki, 1987 .

Inhibition of cofactor activity of protein S by a complex of protein S and C4b-binding protein. Evidence for inactive ternary complex formation between protein S, C4b-binding protein, and activated protein C.

J. Nishioka, K. Suzuki, 1990, The Journal of biological chemistry.

Analysis three abnormal Protein S genes in a patient with pulmonary embolism.

J. Nishioka, M. Ikejiri, K. Nakatani, 2010, Thrombosis research.

Regulatory mechanisms of C4b‐binding protein (C4BP)α and β expression in rat hepatocytes by lipopolysaccharide and interleukin‐6

J. Nishioka, N. Akita, E. Gabazza, 2008, Journal of thrombosis and haemostasis : JTH.

Lipopolysaccharide‐induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFκB activation: involvement of membrane‐bound CD14 and toll‐like receptor‐4

Tatsuya Hayashi, J. Nishioka, E. Gabazza, 2006, Journal of thrombosis and haemostasis : JTH.

Plasma protein S activity measured using Protac, a snake venom derived activator of protein C.

J. Nishioka, K. Suzuki, 1988, Thrombosis research.

Inherited deficiency of protein S in a Japanese family with recurrent venous thrombosis: a study of three generations.

J. Nishioka, H. Saito, K. Ogata, 1986, Blood.

The association of protein S Tokushima-K196E with a risk of deep vein thrombosis

J. Nishioka, M. Ikejiri, K. Nakatani, 2010, International journal of hematology.

Biosynthesis and secretion of functional protein S by a human megakaryoblastic cell line (MEG-01).

K. Suzuki, M. Ogura, J. Nishioka, 1987, Blood.

Effect of endotoxin on coagulation , fibrinolysis , kinin forming and complement systems in Japanese monkeys ( M . fuscata fuscata )

J. Nishioka, Koji Suzuki, Shin Nakamura, 2010 .

Experimental disseminated intravascular coagulation (DIC)

J. Nishioka, Koji Suzuki, Shin Nakamura, 1979 .

Protein C activation in NIDDM patients

M. Sata, K. Murata, J. Nishioka, 1996, Diabetologia.

Molecular characterization of coagulation factor XII deficiency in a Japanese family

Y. Abe, J. Nishioka, K. Nakatani, 2003, Thrombosis and Haemostasis.

Hemostatic markers in Japanese patients undergoing anticoagulant therapy under thrombo-test monitoring.

J. Nishioka, E. Gabazza, H. Shiku, 1999, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Functional studies of a novel Germline p53 splicing mutation identified in a patient with Li–Fraumeni‐Like syndrome

M. Takagi, S. Mizutani, J. Nishioka, 2012, Molecular carcinogenesis.

Inhibition of factor VIII-associated platelet aggregation by heparin and dextran sulfate, and its mechanism.

J. Nishioka, K. Suzuki, S. Hashimoto, 1979, Biochimica et biophysica acta.

Measurement of tissue factor messenger RNA levels in leukocytes from patients in hypercoagulable state caused by several underlying diseases

Y. Abe, J. Nishioka, E. Gabazza, 2003, Thrombosis and Haemostasis.

Edoxaban, a Factor Xa-Specific Direct Oral Anticoagulant, Significantly Suppresses Tumor Growth in Colorectal Cancer Colon26-Inoculated BALB/c Mice

J. Nishioka, N. Akita, Koji Suzuki, 2022, TH Open.

Molecular characterization of 5′‐deoxy‐5′‐methylthioadenosine phosphorylase‐deficient mutant clones of murine lymphoma cell line R1.1

J. Nishioka, Yuwaraj Kadariya, T. Nobori, 2003, Cancer science.

Increased hemostatic molecular markers in patients undergoing anticoagulant therapy.

J. Nishioka, H. Shiku, H. Wada, 2000, Seminars in thrombosis and hemostasis.

Acquired Activated Protein C Resistance in Patients with Lupus Anticoagulant and Essential Thrombocythemia

J. Nishioka, E. Gabazza, Koji Suzuki, 1997 .

The Gla26 Residue of Protein C Is Required for the Binding of Protein C to Thrombomodulin and Endothelial Cell Protein C Receptor, but not to Protein S and Factor Va

Tatsuya Hayashi, J. Nishioka, M. Ido, 1996, Thrombosis and Haemostasis.

A Compound Heterozygous Protein C Deficiency with a Single Nucleotide G Deletion Encoding Gly-381 and an Amino Acid Substitution of Lys for Gla-26

Tatsuya Hayashi, J. Nishioka, M. Ido, 1993, Thrombosis and Haemostasis.

Recognition Sites for Thrombomodulin, Procoagulant and Anticoagulant Proteins around the Active Center of Thrombin

J. Nishioka, Koji Suzuki, 1993 .

Preparation of monoclonal antibodies to human protein C

J. Nishioka, Koji Suzuki, S. Hashimoto, 1984 .

Prenatal Diagnosis of Compound Heterozygous Deficiency of Protein C by Direct Detection of the Mutation Sites

Tatsuya Hayashi, J. Nishioka, M. Ido, 1996, Thrombosis and Haemostasis.

The role of human factor X activation peptide in activation of factor X by factor IXa.

J. Nishioka, T. Nakagaki, K. Suzuki, 1994, Journal of biochemistry.

Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator

Tatsuya Hayashi, J. Nishioka, E. Gabazza, 2007, Journal of thrombosis and haemostasis : JTH.

[Factor V].

J. Nishioka, K. Suzuki, 1987, Rinsho byori. The Japanese journal of clinical pathology.

Characterization of functionally important regions of tissue factor by using monoclonal antibodies.

J. Nishioka, T. Ito, K. Suzuki, 1993, Journal of biochemistry.

Protein S Tokushima: An Abnormal Protein S Found in a Japanese Family with Thrombosis

J. Nishioka, T. Hayashi, K. Suzuki, 1993, Thrombosis and Haemostasis.

Monoclonal Antibodies to Human Protein C: Effects on the Biological Activity of Activated Protein C and the Thrombin-Catalyzed Activation of Protein C

J. Nishioka, Koji Suzuki, S. Hashimoto, 1985 .

Binding site for vitamin K-dependent protein S on complement C4b-binding protein.

J. Nishioka, K. Suzuki, 1988, The Journal of biological chemistry.

Blood coagulation factor Xa interacts with a linear sequence of the kringle 2 domain of prothrombin.

J. Nishioka, K. Suzuki, H. Takeya, 1994, Journal of Biochemistry (Tokyo).

Novel p53 splicing site mutation in Li‐Fraumeni‐like syndrome with osteosarcoma

A. Matsumine, J. Nishioka, Tomoki Nakamura, 2013, Pediatrics international : official journal of the Japan Pediatric Society.

Metformin-induced suppression of glucose-6-phosphatase expression is independent of insulin signaling in rat hepatoma cells.

J. Nishioka, E. Gabazza, K. Nakatani, 2005, International journal of molecular medicine.

Bovine Protein C Inhibitor Has a Unique Reactive Site and Can Transiently Inhibit Plasmin

Tatsuya Hayashi, J. Nishioka, Koji Suzuki, 2000, Thrombosis and Haemostasis.

Prothrombin kringle 1 domain interacts with factor Va during the assembly of prothrombinase complex.

J. Nishioka, E. Gabazza, H. Deguchi, 1997, The Biochemical journal.

Charcterization of protein C inhibitor purified from human plasma: Mechanism of activated protein C inhibition by protein C inhibitor

J. Nishioka, Koji Suzuki, S. Hashimoto, 1983 .

Contributions of platelets to blood coagulation

J. Nishioka, Koji Suzuki, S. Hashimoto, 1983 .

Contributions of platelets to blood coagulation Activation of the zymogen of antithrombin III / heparin resistant enzyme in platelet-rich plasma -

J. Nishioka, Koji Suzuki, S. Hashimoto, 2010 .

A Novel Mutant Protein C (Protein C Sakaiminato) Caused by an Amino Acid Substitution of Ser250 to Asn in a Noonan Syndrome Child

Tatsuya Hayashi, J. Nishioka, Koji Suzuki, 1998 .

Inherited deficiency of functional and free form protein S.

J. Nishioka, K. Nakamura, T. Mori, 1989, Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society.

A new method of cea determination by latex agglutination using integrating sphere turbidimetric assay ista

J. Nishioka, M. Yamashiki, A. Nishimura, 1990 .