J. Desimone

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by Phosphatidylinositol 4, 5-Bisphosphate Regulation of the Putative TRPV1t Salt Taste Receptor

B. Nilius, K. Murthy, J. Desimone, 2015 .

Activation of the umami taste receptor (T1R1/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon.

K. Murthy, J. Desimone, V. Lyall, 2014, American journal of physiology. Gastrointestinal and liver physiology.

Regulation of the putative TRPV1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate.

K. Murthy, J. Desimone, V. Lyall, 2010, Journal of neurophysiology.

Regulation of the Putative Trpv1t Salt Taste Receptor by Phosphatidylinositol 4, 1 5-bisphosphate 2 3

K. Murthy, J. Desimone, V. Lyall, 2009 .

Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway.

J. Desimone, G. Heck, S. Mierson, 1984, Science.

Basolateral Na+–H+ exchanger‐1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli

J. Desimone, V. Lyall, T. Phan, 2004, The Journal of physiology.

The mammalian amiloride‐insensitive non‐specific salt taste receptor is a vanilloid receptor‐1 variant

Shobha Ghosh, J. Bigbee, J. Desimone, 2004, The Journal of physiology.

Principles and models of biological transport

J. Desimone, 1987 .

The location of olfactory receptor sites. Inferences from latency measurements.

T. Getchell, S. Price, J. Desimone, 1980, Biophysical journal.

Chemical Modulators of Taste

J. Desimone, V. Lyall, G. Dubois, 2015 .

Perturbations in the sof the double layer at an enzymic surface

J. Desimone, 1977 .

A New Asymptotic Analysis of the nth Order Reaction-Diffusion Problem: Analytical and Numerical Studies

J. Desimone, J. A. Pennline, 1978 .

The determination of local reaction and diffusion parameters of enzyme membranes from global measurements.

J. Desimone, S. Caplan, 1973, Biochemistry.

Taste receptors in the gastrointestinal tract III. Salty and sour taste: sensing of sodium and protons by the tongue.

J. Desimone, V. Lyall, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Effect of nicotine on chorda tympani responses to salty and sour stimuli.

G. Kobal, J. Desimone, V. Lyall, 2007, Journal of neurophysiology.

Ethanol Modulates the VR-1 Variant Amiloride-insensitive Salt Taste Receptor. II. Effect on Chorda Tympani Salt Responses

J. Desimone, V. Lyall, T. Phan, 2005, The Journal of general physiology.

Cynomolgus Macaque: The Quality of Bitterness Gustatory Neural Coding in the Cortex of the Alert

Michael L. Lavine, R. Wolpert, M. Nicolelis, 2015 .

Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids.

J. Desimone, V. Lyall, T. Phan, 2011, Chemical senses.

Intracellular pH Modulates Taste Receptor Cell Volume and the Phasic Part of the Chorda Tympani Response to Acids

J. Desimone, V. Lyall, T. Phan, 2006, The Journal of general physiology.

Anion Size of Sodium Salts and Simple Taste Reaction Times

J. Delwiche, B. P. Halpern, J. Desimone, 1999, Physiology & Behavior.

Salt-evoked lingual surface potential in humans.

J. Desimone, V. Lyall, G. Heck, 2003, Journal of neurophysiology.

Regulation of the benzamil-insensitive salt taste receptor by intracellular Ca2+, protein kinase C, and calcineurin.

K. Murthy, J. Desimone, V. Lyall, 2009, Journal of neurophysiology.

4.14 – Amiloride-Sensitive Ion Channels

J. Desimone, V. Lyall, 2008 .

A psychophysical and electrophysiological analysis of salt taste in Trpv1 null mice.

J. Desimone, V. Lyall, Y. Treesukosol, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

A novel pharmacological probe links the amiloride-insensitive NaCl, KCl, and NH(4)Cl chorda tympani taste responses.

J. Desimone, V. Lyall, T. Phan, 2001, Journal of neurophysiology.

Voltage dependence of the rat chorda tympani response to Na+ salts: implications for the functional organization of taste receptor cells.

Q. Ye, J. Desimone, G. Heck, 1993, Journal of neurophysiology.

The anion paradox in sodium taste reception: resolution by voltage-clamp studies.

Q. Ye, J. Desimone, G. Heck, 1991, Science.

The identity of the current carriers in canine lingual epithelium in vitro.

J. Desimone, G. Heck, S. Mierson, 1985, Biochimica et biophysica acta.

and umami taste in humans and animal models -geranyl cyclopropyl-carboximide modulates salty N

M. Rhyu, J. Desimone, V. Lyall, 2015 .

N-geranyl cyclopropyl-carboximide modulates salty and umami taste in humans and animal models.

M. Rhyu, J. Desimone, V. Lyall, 2013, Journal of neurophysiology.

Ethanol Modulates the VR-1 Variant Amiloride-insensitive Salt Taste Receptor. I. Effect on TRC Volume and Na+ Flux

J. Desimone, V. Lyall, T. Phan, 2005, The Journal of general physiology.

Dialysis disequilibrium syndrome (DDS) in the rat: role of the "reverse urea effect".

J. Desimone, S. Silver, J. Desimone, 1992, Kidney international.

Development of rat chorda tympani sodium responses: evidence for age-dependent changes in global amiloride-sensitive Na(+) channel kinetics.

J. Desimone, G. Heck, D. Hill, 2000, Journal of neurophysiology.

An alternative to allosteric interactions as causes of sigmoid dose versus response curves. Application to glucose-induced secretion of insulin.

S. Price, J. Desimone, 1978, Biochimica et biophysica acta.

TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.

M. Rhyu, K. Murthy, J. Desimone, 2013, American journal of physiology. Gastrointestinal and liver physiology.

Dietary Na(+)-restriction prevents development of functional Na+ channels in taste cell apical membranes: proof by in vivo membrane voltage perturbation.

Q. Ye, J. Desimone, G. Heck, 1993, Journal of neurophysiology.

Sugar-activated ion transport in canine lingual epithelium. Implications for sugar taste transduction

J. Desimone, G. Heck, S. Mierson, 1988, The Journal of general physiology.

The active ion transport properties of canine lingual epithelia in vitro. Implications for gustatory transduction

J. Desimone, G. Heck, S. Mierson, 1984, The Journal of general physiology.

Active ion transport in dog tongue: a possible role in taste.

J. Desimone, G. Heck, S. Desimone, 1981, Science.

Direct measurement of translingual epithelial NaCl and KCl currents during the chorda tympani taste response.

K. Persaud, J. Desimone, G. Heck, 1989, Biophysical journal.

Surface active taste modifiers: A comparison of the physical and psychophysical properties of gymnemic acid and sodium lauryl sulfate.

L. Bartoshuk, J. Desimone, G. Heck, 1980 .

A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor.

J. Desimone, V. Lyall, T. Phan, 2005, Chemical senses.

A nonlinear boundary value problem arising in the structure of the double layer at an enzymatic surface

D. Mikulecky, J. Desimone, J. A. Pennline, 1977 .

Acid detection by taste receptor cells.

J. Desimone, V. Lyall, G. Heck, 2001, Respiration physiology.

Odorant stimulation of secretory and neural processes in the salamander olfactory mucosa

T. Getchell, B. Zielinski, J. Desimone, 1987, Journal of Comparative Physiology A.

Effects of voltage perturbation of the lingual receptive field on chorda tympani responses to Na+ and K+ salts in the rat: implications for gustatory transduction

Q. Ye, J. Desimone, G. Heck, 1994, The Journal of general physiology.

An Empirical Relation for the Surface Potential of Phosphatidic Acid Monolayers: Its Dependence on Calcium and the Role of Double Layer Theory

J. Desimone, G. Heck, S. Desimone, 1986 .

An analysis of the effects of stimulus transport and membrane charge on the salt, acid and water-response of mammals

J. Desimone, G. Heck, 1980 .

Analysis of amiloride inhibition of chorda tympani taste response of rat to NaCl.

J. Desimone, F. Ferrell, 1985, The American journal of physiology.

Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats

A. Spielman, M. Rhyu, K. Murthy, 2017, PloS one.

Effect of Maillard Reacted Peptides on Human Salt Taste and the Amiloride-Insensitive Salt Taste Receptor (TRPV1t)

J. Desimone, V. Lyall, T. Phan, 2008, Chemical senses.

Modulation of Rat Chorda Tympani NaCl Responses and Intracellular Na+ Activity in Polarized Taste Receptor Cells by pH

J. Desimone, V. Lyall, T. Phan, 2002, The Journal of general physiology.

Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli.

J. Desimone, V. Lyall, T. Phan, 2012, Journal of neurophysiology.

Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to salty and sour taste stimuli.

J. Desimone, V. Lyall, T. Phan, 2012, Journal of neurophysiology.

Transcellular and Paracellular Pathways in Taste Buds Mediate Salt Chemoreception: The Location of Na + Transducing Channels

Q. Ye, J. Desimone, G. Heck, 1994 .

Ion pathways in the taste bud and their significance for transduction.

Q. Ye, J. Desimone, G. Heck, 1993, Ciba Foundation symposium.

Acid-induced responses in hamster chorda tympani and intracellular pH tracking by taste receptor cells.

J. Desimone, V. Lyall, G. Heck, 1998, American journal of physiology. Cell physiology.

VOLTAGE CLAMP STUDIES OF THE ISOLATED OLFACTORY MUCOSA - IMPLICATIONS FOR OLFACTORY TRANSDUCTION

T. Getchell, K. Persaud, J. Desimone, 1987 .

Self-inhibition in Ca2+ -evoked taste responses: a novel tool for functional dissection of salt taste transduction mechanisms.

J. Desimone, G. Heck, M. A. Kloub, 1998, Journal of neurophysiology.

Effect of FeCl3 on ion transport in isolated frog skin

J. Desimone, T. Biber, T. L. Mullen, 2005, The Journal of Membrane Biology.

Potential dependence of unidirectional chloride fluxes across isolated frog skin.

J. Desimone, K. Drewnowska, T. Biber, 1986, Biochimica et biophysica acta.

Taste-mixture suppression: functional dissection of cellular and paracellular origins.

J. Desimone, G. Heck, R. E. Stewart, 1996, Journal of neurophysiology.

Effects of osmolarity on taste receptor cell size and function.

J. Desimone, V. Lyall, G. Heck, 1999, American journal of physiology. Cell physiology.

11 – Physicochemical Principles in Taste and Olfaction

J. Desimone, 1981 .

Otopetrin-1: A sour-tasting proton channel

J. Desimone, I. S. Ramsey, 2018, The Journal of general physiology.

Chorda tympani responses under lingual voltage clamp: implications for NH4 salt taste transduction.

J. Desimone, G. Heck, M. A. Kloub, 1997, Journal of neurophysiology.

Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction.

J. Desimone, V. Lyall, T. Phan, 2001, American journal of physiology. Cell physiology.

Perturbations in the structure of the double layer at an enzymic surface.

J. Desimone, 1977, Journal of theoretical biology.

The electrostatic contribution of divalent ions to the surface pressure of charged monolayers

J. Desimone, 1978 .

Regulatory Effects of Ca2+ and H+ on the Rat Chorda Tympani Response to NaCl and KCl.

M. Rhyu, J. Desimone, V. Lyall, 2015, Chemical senses.

MODELS OF TASTE RECEPTOR CELL STIMULATION

John A. DeSimone, S. Price, J. Desimone, 1977 .

Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats.

K. Murthy, J. Desimone, V. Lyall, 2011, Journal of neurophysiology.

Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine

J. Desimone, V. Lyall, Zuojun Ren, 2015, PloS one.

Nicotine activates TRPM5-dependent and independent taste pathways

Jennifer R. Stapleton-Kotloski, M. Nicolelis, A. Oliveira-Maia, 2009, Proceedings of the National Academy of Sciences.

Ion transport across the frog olfactory mucosa: the action of cyclic nucleotides on the basal and odorant-stimulated states.

T. Getchell, K. Persaud, J. Desimone, 1988, Biochimica et biophysica acta.

Exchange Activity in Taste Receptor Cells + -H + Na

Paul V. Watkins, J. Voipio, K. Kaila, 2015 .

Na+-H+ exchange activity in taste receptor cells.

M. Knepper, J. Desimone, V. Lyall, 2004, Journal of neurophysiology.

Sodium in the food supply: challenges and opportunities.

A. Drewnowski, G. Beauchamp, J. Desimone, 2013, Nutrition reviews.

Lingual epithelium of spontaneously hypertensive rats has decreased short-circuit current in response to NaCl.

C. Gennings, J. Desimone, S. Mierson, 1988, Hypertension.

Symmetry and the stationary state behavior of enzyme membranes.

J. Desimone, S. Caplan, S R Caplan, 1973, Journal of theoretical biology.

Chemical Mechanical Polishing of Tungsten: Effect of Tungstate Ion on the Electrochemical Behavior of Tungsten

J. Desimone, M. Anik, K. Osseo-Asare, 1999 .

N-geranylcyclopropylcarboximide (ngcc) Modulates Salty and Umami Taste in 1 Humans and Animal Models 2 3

Shobha, M. Rhyu, J. Desimone, 2012 .

Effect of ENaC Modulators on Rat Neural Responses to NaCl

M. Rhyu, J. Desimone, V. Lyall, 2014, PloS one.

The K+-H+ exchanger, nigericin, modulates taste cell pH and chorda tympani taste nerve responses to acidic stimuli.

J. Desimone, V. Lyall, T. Phan, 2011, Chemical senses.

Effects of osmolarity on taste receptor cell size and function.

J. Desimone, V. Lyall, G. Heck, 1999, American Journal of Physiology.

Excitation and adaptation in the detection of hydrogen ions by taste receptor cells: a role for cAMP and Ca(2+).

J. Desimone, V. Lyall, T. Phan, 2002, Journal of neurophysiology.

cAMP and Ca Hydrogen Ions by Taste Receptor Cells: A Role for Excitation and Adaptation in the Detection of

J. Desimone, V. Lyall, T. Phan, 2015 .

Acid-induced responses in hamster chorda tympani and intracellular pH tracking by taste receptor cells.

J. Desimone, V. Lyall, G. Heck, 1998, The American journal of physiology.

Effects of extracellular pH, PCO2, and HCO3- on intracellular pH in isolated rat taste buds.

J. Desimone, V. Lyall, G. Heck, 1997, The American journal of physiology.

Stimulus-Evoked Transepithelial Lingual Currents and the Gustatory Neural Response

J. Desimone, G. Heck, S. Mierson, 2021 .

Correction: Otopetrin-1: A sour-tasting proton channel

J. Desimone, I. S. Ramsey, 2018, The Journal of general physiology.

The dependence of the phasic response of the taste nerves on stimulus flow rate arises in the diffusion boundary layer region at the lingual surface: A convective-diffusion analysis

J. Desimone, 2017 .

Chorda tympani taste response of rat to hydrochloric acid subject to voltage-clamped lingual receptive field.

J. Desimone, G. Heck, E. M. Callaham, 1995, The American journal of physiology.

Ion transport across the frog olfactory mucosa: the basal and odorant-stimulated states.

T. Getchell, K. Persaud, J. Desimone, 1987, Biochimica et biophysica acta.

Evidence for electrogenic active ion transport across the frog olfactory mucosa in vitro

T. Getchell, J. Desimone, G. Heck, 1984 .

Membrane currents in taste cells of the rat fungiform papilla. Evidence for two types of Ca currents and inhibition of K currents by saccharin

B. Lindemann, J. DeSimone, J. Desimone, 1990, The Journal of general physiology.

The active ion transport properties of canine lingual epithelia in vitro. Implications for gustatory transduction

J. Desimone, G. Heck, S. Mierson, 1984, The Journal of general physiology.

Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to salty and sour taste stimuli.

J. Desimone, V. Lyall, T. Phan, 2012, Journal of neurophysiology.

Electrophysiological studies of salt-sensitive taste receptors

Q. Ye, J. Desimone, G. Heck, 1991, IEEE Proceedings of the SOUTHEASTCON '91.

A model for the stimulation of taste receptor cells by salt.

S. Price, J. Desimone, 1976, Biophysical journal.

Physiology and psychophysics in taste and smell

K. Persaud, J. Desimone, G. Heck, 1988 .

Trigeminal Ganglion Neurons Currents by Capsaicin in Rat A I Modulation of

Erin K. Purcell, Mingjie Tong, John A. DeSimone, 2015 .