K. Takeuchi

发表

Editorial overview: Gastrointestinal: gastrointestinal research-mucosal injury, protection, and repair at organ, cellular, and molecular levels.

Jian-ying Wang, K. Takeuchi, 2014, Current opinion in pharmacology.

Consensus of the Present and Prospects on Endoscopic Diagnosis and Treatment in East Asian Countries

A. Terano, K. Hahm, T. Joh, 2012, Diagnostic and therapeutic endoscopy.

ROLE OF MACROPHAGE COLONY-STIMULATING FACTOR (M-CSF)-DEPENDENT MACROPHAGES IN GASTRIC ULCER HEALING IN MICE

K. Takeuchi, Y. Kawahara, S. Kato, 2011 .

ACE inhibitor and AT1 antagonist stimulate duodenal HCO3- secretion mediated by a common pathway - involvement of PG, NO and bradykinin.

K. Takeuchi, M. Hayashi, E. Aihara, 2005, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Gastric cytoprotection by prostaglandin E₂ and prostacyclin: relationship to EP1 and IP receptors.

K. Takeuchi, 2014, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Roles of enterobacteria, nitric oxide and neutrophil in pathogenesis of indomethacin-induced small intestinal lesions in rats.

K. Takeuchi, A. Konaka, T. Kunikata, 1999, Pharmacological research.

Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.

K. Takeuchi, A. Tanaka, R. Ohno, 2003, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Rofecoxib Produces Intestinal but Not Gastric Damage in the Presence of a Low Dose of Indomethacin in Rats

K. Takeuchi, A. Tanaka, A. Yokota, 2005, Journal of Pharmacology and Experimental Therapeutics.

Dopamine-induced protection against indomethacin-evoked intestinal lesions in rats--role of anti-intestinal motility mediated by D2 receptors.

K. Takeuchi, S. Kato, T. Miyazawa, 2003, Medical science monitor : international medical journal of experimental and clinical research.

The Effects of TAK-875, a Selective G Protein-Coupled Receptor 40/Free Fatty Acid 1 Agonist, on Insulin and Glucagon Secretion in Isolated Rat and Human Islets

P. Rorsman, Paul R. V. Johnson, K. Takeuchi, 2012, Journal of Pharmacology and Experimental Therapeutics.

High-Mobility Group Box 1 Inhibits Gastric Ulcer Healing through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products

K. Tominaga, Toshio Watanabe, Y. Fujiwara, 2013, PloS one.

Nonsteroidal Antiinflammatory Drug-Induced Gastrointestinal Toxicity

K. Takeuchi, 2018 .

NSAID-Induced Small Intestinal Damage - Roles of Various Pathogenic Factors

K. Takeuchi, H. Satoh, 2015, Digestion.

Mucosal Protective Agents Prevent Exacerbation of NSAID-Induced Small Intestinal Lesions Caused by Antisecretory Drugs in Rats

K. Takeuchi, H. Satoh, K. Amagase, 2013, The Journal of Pharmacology and Experimental Therapeutics.

The Role of Food for the Formation and Prevention of Gastrointestinal Lesions Induced by Aspirin in Cats

K. Takeuchi, H. Satoh, K. Amagase, 2013, Digestive Diseases and Sciences.

Role of Food and Enterobacteria in the Formation and Prevention of Small Intestinal Damage Induced by NSAIDs

K. Takeuchi, H. Satoh, 2012 .

Measurement of small intestinal damage.

K. Takeuchi, H. Satoh, 2010, Current protocols in toxicology.

Pathogenic Importance of Intestinal Hypermotility in NSAID-Induced Small Intestinal Damage in Rats

K. Takeuchi, T. Kunikata, A. Tanaka, 2002, Digestion.

Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage.

K. Takeuchi, A. Tanaka, T. Miyazawa, 2002, The Journal of pharmacology and experimental therapeutics.

16,16-Dimethyl Prostaglandin E2 Inhibits Indomethacin-Induced Small Intestinal Lesions Through EP3 and EP4 Receptors

K. Takeuchi, T. Kunikata, A. Tanaka, 2002, Digestive Diseases and Sciences.

Functional mechanism underlying cyclooxygenase‐2 expression in rat small intestine following administration of indomethacin: Relation to intestinal hypermotility

K. Takeuchi, Y. Hayashi, A. Tanaka, 2005, Journal of gastroenterology and hepatology.

Protective effect of pranlukast, a cysteinyl-leukotriene receptor 1 antagonist, on indomethacin-induced small intestinal damage in rats

K. Takeuchi, Y. Hayashi, H. Nishio, 2007, Inflammopharmacology.

Protective effect of pranlukast, a cysteinyl-leukotriene receptor 1 antagonist, on indomethacin-induced small intestinal damage in rats

K. Takeuchi, Y. Hayashi, H. Nishio, 2008, Inflammopharmacology.

Role of nitric oxide in mucosal blood flow response and the healing of HCl-induced lesions in the rat stomach.

K. Takeuchi, S. Kato, K. Takehara, 1997, Digestion.

Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice.

C. Yabe-Nishimura, K. Takeuchi, N. Yamanaka, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.

K. Takeuchi, Y. Moritoh, T. Asakawa, 2008, European journal of pharmacology.

Steady-state energy balance in animal models of obesity and weight loss

P. Barrett, B. Kulseng, K. Takeuchi, 2017, Scandinavian journal of gastroenterology.

Mucosal irritative and healing impairment action of risedronate in rat stomachs: Comparison with alendronate

K. Takeuchi, S. Kato, E. Aihara, 2004, Journal of gastroenterology and hepatology.

Fasiglifam (TAK‐875) has dual potentiating mechanisms via Gαq‐GPR40/FFAR1 signaling branches on glucose‐dependent insulin secretion

K. Takeuchi, H. Komatsu, M. Maruyama, 2016, Pharmacology research & perspectives.

Anti-Inflammatory Effects of Pravastatin on Helicobacter Pylori-Induced Gastritis in Mice

K. Tominaga, Toshio Watanabe, Y. Fujiwara, 2007, Digestive Diseases and Sciences.

The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice.

K. Takeuchi, Y. Moritoh, T. Asakawa, 2009, European journal of pharmacology.

An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans.

C. Newgard, J. Schisler, J. Bain, 2004, Diabetes.

Diethyldithiocarbamate, a superoxide dismutase inhibitor, reduces indomethacin-induced gastric lesions in rats.

K. Takeuchi, K. Takehara, T. Ohuchi, 1996, Digestion.

Gastric ulcerogenic and healing impairment effects of risedronate, a nitrogen-containing bisphosphonate in rats. Comparison with alendronate and minodronate.

K. Takeuchi, K. Amagase, T. Senta, 2011, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Aggravation by Clopidogrel , an Antiplatelet Drug , of Antral Lesions Induced by NSAIDs in Rats

K. Takeuchi, H. Nishio, K. Yamasaki, 2016 .

A Role for HSP70 in Protecting against Indomethacin-induced Gastric Lesions*

G. Sobue, K. Takeuchi, A. Nakai, 2009, The Journal of Biological Chemistry.

Aggravation of cold-restraint stress-induced gastric lesions in adjuvant arthritic rats: pathogenic role of inducible and endothelial nitric oxide.

K. Takeuchi, S. Kato, K. Amagase, 2009, Journal of pharmacological sciences.

Increased susceptibility of small intestine to NSAID-provoked ulceration in rats with adjuvant-induced arthritis: involvement of enhanced expression of TLR4.

K. Takeuchi, S. Kato, K. Amagase, 2007, Life sciences.

[Changes in ulcerogenic response to non-steroidal antiinflammatory drugs (NSAIDs) in the gastrointestine during chronic arthritis].

K. Takeuchi, S. Kato, 2006, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

The roles of nitric oxide and prostaglandins in alterations of ulcerogenic and healing responses in adjuvant‐induced arthritic rat stomachs

K. Takeuchi, T. Kunikata, A. Tanaka, 2000, Alimentary pharmacology & therapeutics.

Changes in gastric mucosal ulcerogenic responses in rats with adjuvant arthritis: role of nitric oxide

K. Takeuchi, T. Kunikata, A. Tanaka, 1999, Alimentary pharmacology & therapeutics.

[Prophylactic effect of glutamate on gastrointestinal damage].

K. Takeuchi, S. Kato, K. Amagase, 2011, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity

H. Ueno, K. Takeuchi, Mitsugi Ookawara, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Different effects of dexamethasone and the nitric oxide synthase inhibitor L-NAME on caerulein-induced rat acute pancreatitis, depending on the severity

K. Takeuchi, S. Mitsufuji, S. Kato, 2006, InflammoPharmacology.

Amelioration of caerulein-induced pancreatitis by restraint stress in the rat

K. Takeuchi, S. Mitsufuji, S. Kato, 2002, InflammoPharmacology.

Prophylactic Effect of Restraint Stress on Cerulein-Induced Pancreatitis in Rats: Role of Endogenous Glucocorticoids

K. Takeuchi, S. Mitsufuji, S. Kato, 2004, Digestive Diseases and Sciences.

Combining a dipeptidyl peptidase‐4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and β‐cell function in db/db mice

K. Takeuchi, Y. Moritoh, T. Asakawa, 2009, British journal of pharmacology.

Combination treatment with alogliptin and voglibose increases active GLP‐1 circulation, prevents the development of diabetes and preserves pancreatic beta‐cells in prediabetic db/db mice

K. Takeuchi, Y. Moritoh, M. Hazama, 2010, Diabetes, obesity & metabolism.

Genetic Evidence for a Protective Role for Heat Shock Factor 1 and Heat Shock Protein 70 against Colitis*

G. Sobue, K. Takeuchi, A. Nakai, 2007, Journal of Biological Chemistry.

A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1

K. Takeuchi, H. Komatsu, Y. Habata, 2013, PloS one.

Healing of Duodenal Ulcers Is Not Impaired by Indomethacin or Rofecoxib, the Selective COX-2 Inhibitor, in Rats

K. Takeuchi, A. Tanaka, M. Matsumoto, 2002, Digestion.

Increased Susceptibility of Diabetic Rat Gastric Mucosa to Food Deprivation during Cold Stress

K. Takeuchi, S. Kato, R. Korolkiewicz, 1999, Digestion.

Protection against dextran sulfate sodium-induced colitis by microspheres of ellagic acid in rats.

Y. Jeong, K. Takeuchi, N. Shibata, 2002, Life sciences.

Application of Eudragit P‐4135F for the delivery of ellagic acid to the rat lower small intestine

Y. Jeong, K. Takeuchi, N. Shibata, 2001, The Journal of pharmacy and pharmacology.

Chapter 43 – Gastroduodenal Mucosal Defense

J. Kaunitz, K. Takeuchi, M. Montrose, 2012 .

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125.

J. Yano, K. Aertgeerts, K. Takeuchi, 2011, Bioorganic & medicinal chemistry.

Inhibition by antipsychotic drugs of L-type Ca2+ channel current in PC12 cells.

S. Koizumi, Y. Ohno, K. Takeuchi, 1996, European journal of pharmacology.

The Absence of Urokinase-type Plasminogen Activator Receptor Plays a Role in the Insulin-independent Glucose Metabolism

K. Takeuchi, K. Okada, O. Matsuo, 2011, Journal of cardiovascular pharmacology.

GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve

H. Ueno, K. Takeuchi, M. Maruyama, 2019, PloS one.

Increased susceptibility of gastric mucosa to ulcerogenic stimulation in diabetic rats–role of capsaicin‐sensitive sensory neurons

K. Takeuchi, R. Korolkiewicz, K. Tashima, 1998, British journal of pharmacology.

Rodent Models of Diabetes

K. Takeuchi, Bumsup Lee, J. ChristopherRonald, 2010 .

Involvement of prostaglandin E receptor EP3 subtype in duodenal bicarbonate secretion in rats.

K. Takeuchi, E. Aihara, Y. Nomura, 2007, Life sciences.

Roles of Endogenous Prostaglandins and Cyclooxygenase Isozymes in Healing of Indomethacin-Induced Small Intestinal Lesions in Rats

K. Takeuchi, A. Tanaka, R. Ohno, 2006, Journal of Pharmacology and Experimental Therapeutics.

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.

Masahiro Ito, Toshimasa Tanaka, S. Mikami, 2010, ACS medicinal chemistry letters.

Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.

Masahiro Ito, S. Mikami, K. Takeuchi, 2012, Journal of medicinal chemistry.

Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554.

M. Sasaki, J. Yano, K. Aertgeerts, 2011, Bioorganic & medicinal chemistry.

Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats.

K. Takeuchi, T. Kunikata, A. Tanaka, 1999, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Oxygen Free Radicals and Lipid Peroxidation in the Pathogenesis of Gastric Mucosal Lesions Induced by Indomethacin in Rats

K. Takeuchi, Y. Fujioka, K. Ueshima, 1991 .

Luminal Calcium in Regulation of Nitric Oxide Release and Acid Secretion in Rat Stomachs After Damage

K. Takeuchi, A. Konaka, S. Kato, 1999, Digestive Diseases and Sciences.

Roles of pro-angiogenic and anti-angiogenic factors as well as matrix metalloproteinases in healing of NSAID-induced small intestinal ulcers in rats.

K. Takeuchi, K. Amagase, Rie Matsuoka, 2013, Life sciences.

Quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients.

K. Tomita, K. Takeuchi, M. Otagiri, 2011, Journal of pharmaceutical sciences.

A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs.

K. Takeuchi, N. Yamada, E. Hashimoto, 2012, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Activation of Muscarinic Acetylcholine Receptor Subtype 4 Is Essential for Cholinergic Stimulation of Gastric Acid Secretion: Relation to D Cell/Somatostatin

K. Takeuchi, S. Hayashi, T. Aihara, 2016, Front. Pharmacol..

Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin.

K. Takeuchi, E. Aihara, S. Hayashi, 2015, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[Gastrointestinal sparing anti-inflammatory drugs--COX-2 selective inhibitors and NO-releasing NSAIDs].

K. Takeuchi, A. Tanaka, 2001, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Role of endogenous nitric oxide (NO) and NO synthases in healing of indomethacin-induced intestinal ulcers in rats.

K. Takeuchi, A. Tanaka, R. Ohno, 2007, Life sciences.

Dexamethasone Damages the Rat Stomach but Not Small Intestine During Inhibition of COX-1

K. Takeuchi, A. Tanaka, A. Yokota, 2007, Digestive Diseases and Sciences.

Role of endogenous nitric oxide in mucosal defense of inflamed rat stomach following iodoacetamide treatment.

K. Takeuchi, Y. Hayashi, H. Nishio, 2006, Life sciences.

COX and NOS Isoforms Involved in Acid-Induced Duodenal Bicarbonate Secretion in Rats

K. Takeuchi, S. Kagawa, S. Kawauchi, 2002, Digestive Diseases and Sciences.

Protection by constitutively formed nitric oxide of intestinal damage induced by indomethacin in rats

K. Takeuchi, H. Mizoguchi, T. Kunikata, 2001, Journal of Physiology-Paris.

Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress

K. Takeuchi, H. Mizoguchi, Keizo Suzuki, 1999, Journal of Physiology-Paris.

Inducible types of cyclooxygenase and nitric oxide synthase in adaptive cytoprotection in rat stomachs

K. Takeuchi, T. Kunikata, A. Tanaka, 1998, Journal of Physiology-Paris.

5‐HT3 receptor antagonists ameliorate 5‐fluorouracil‐induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells

K. Takeuchi, N. Yamanaka, S. Kato, 2013, British journal of pharmacology.

Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids

K. Takeuchi, K. Nagahama, Kenji Nagahama, 2014, BioMed research international.

Biphasic Effect of Prostaglandin E2 in a Rat Model of Esophagitis Mediated by EP1 Receptors: Relation to Pepsin Secretion

K. Takeuchi, S. Kato, M. Yamato, 2005, Digestion.

Prostaglandin E2 aggravates gastric mucosal injury induced by histamine in rats through EP1 receptors.

K. Takeuchi, A. Yokota, S. Hase, 2003, Life sciences.

Pathogenic Role of Endothelial Nitric Oxide Synthase (eNOS/NOS-III) in Cerulein-Induced Rat Acute Pancreatitis

T. Okanoue, K. Takeuchi, S. Mitsufuji, 2006, Digestive Diseases and Sciences.

Prostaglandin E Inhibits Indomethacin-Induced Gastric Lesions through EP-1 Receptors

K. Takeuchi, H. Mizoguchi, Keizo Suzuki, 2001, Digestion.

New therapeutic strategy for amino acid medicine: preface.

H. Uneyama, K. Takeuchi, 2012, Journal of pharmacological sciences.

Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats.

K. Takeuchi, S. Kato, K. Yagi, 1997, Gastroenterology.

Gastroprotective action of glucocorticoid hormones during NSAID treatment

K. Takeuchi, A. Tanaka, L. Filaretova, 2006, InflammoPharmacology.

Mechanisms by which endogenous glucocorticoid protects against indomethacin-induced gastric injury in rats.

K. Takeuchi, A. Tanaka, S. Kato, 2002, American journal of physiology. Gastrointestinal and liver physiology.

15th International Conference on Ulcer Research (ICUR)

Takuji Tanaka, J. Wallace, K. Takeuchi, 2015, Digestive Diseases and Sciences.

New frontiers in gut nutrient sensor research: prophylactic effect of glutamine against Helicobacter pylori-induced gastric diseases in Mongolian gerbils.

K. Torii, H. Uneyama, K. Takeuchi, 2010, Journal of pharmacological sciences.

The absence of uPAR is associated with the progression of dermal fibrosis.

K. Takeuchi, K. Okada, O. Matsuo, 2008, The Journal of investigative dermatology.

Ulcerogenic Influence of Selective Cyclooxygenase-2 Inhibitors in the Rat Stomach with Adjuvant-Induced Arthritis

Toshio Watanabe, T. Arakawa, K. Takeuchi, 2002, Journal of Pharmacology and Experimental Therapeutics.

[Anti-inflammatory activity of the dry distillation tar of delipidated soybean (Glyteer) (3). Effects on type I-type IV allergic reaction].

K. Takeuchi, K. Ito, S. Namikawa, 1990, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists.

Masahiro Ito, Toshimasa Tanaka, K. Takeuchi, 2012, Journal of medicinal chemistry.

KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration.

Takuji Tanaka, K. Takeuchi, Yoshihide Miyake, 2015, European journal of pharmacology.

Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats.

K. Takeuchi, S. Kato, K. Amagase, 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Selective cyclooxygenase-2 inhibitor induces gastric mucosal damage in adrenalectomized rats

K. Takeuchi, A. Tanaka, L. Filaretova, 2002, InflammoPharmacology.

Effect of intravenous iron administration frequency on AOPP and inflammatory biomarkers in chronic hemodialysis patients: a pilot study.

J. Nagano, K. Tomita, K. Takeuchi, 2008, Clinical biochemistry.

Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole

K. Higuchi, K. Takeuchi, M. Murano, 2009, Journal of clinical biochemistry and nutrition.

Influence of prednisolone on gastric alkaline response in rat stomach

K. Takeuchi, Y. Nobuhara, S. Ueki, 1985, Digestive Diseases and Sciences.

Effect of taurine on ulcerogenic response and impaired ulcer healing induced by monochloramine in rat stomachs

K. Takeuchi, S. Kato, K. Kanatsu, 2002, Alimentary pharmacology & therapeutics.

Monochloramine impairs mucosal blood flow response and healing of gastric lesions in rats: Relation to capsaicin‐sensitive sensory neurons

K. Takeuchi, H. Mizoguchi, Keizo Suzuki, 2001, Journal of gastroenterology and hepatology.

Effect of monochloramine on recovery of gastric mucosal integrity and blood flow response in rat stomachs--relations to capsaicin-sensitive sensory neurons.

K. Takeuchi, O. Furukawa, H. Araki, 1999, Life sciences.

Irritant action of monochloramine in rat stomachs: effects of zinc L-carnosine (polaprezinc).

K. Takeuchi, S. Kato, H. Nishiwaki, 1997, General pharmacology.

The role and interactions of nitric oxide (NO), carbon monoxide (CO), and prostanoids in the pathogenesis of postoperative ileus in rats

K. Takeuchi, M. Ujda, L. Bieniaszewski, 2004, Journal of Gastrointestinal Surgery.

The role of capsaicin-sensitive sensory neurons in healing of HCl-induced gastric mucosal lesions in rats.

K. Takeuchi, K. Ueshima, S. Okabe, 1994, Gastroenterology.

Influence of Adrenalectomy on Protective Effects of Urocortin I, a Corticotropin-Releasing Factor, Against Indomethacin-Induced Entero-pathy in Rats

K. Takeuchi, N. Abe, A. Kumano, 2016, Current neuropharmacology.

Urocortin Prevents Indomethacin-Induced Small Intestinal Lesions in Rats Through Activation of CRF2 Receptors

K. Takeuchi, Y. Kubo, K. Amagase, 2010, Digestive Diseases and Sciences.

Effects of Diabetes mellitus on the Contractile Activity of Carbachol and Galanin in Isolated Gastric Fundus Strips of Rats

K. Takeuchi, A. Szyk, P. Rekowski, 1998, Pharmacology.

Follow-Up of Exocrine Pancreatic Function in Type-1 Diabetes mellitus

T. Hwang, Y. Jan, A. Zinsmeister, 2005, Digestion.

Effects of acetylsalicylic acid (ASA), ASA plus L-glutamine and L-glutamine on healing of chronic gastric ulcer in the rat.

K. Takeuchi, K. Honda, S. Okabe, 1976, Digestion.

Regulatory mechanism of duodenal bicarbonate secretion: Roles of endogenous prostaglandins and nitric oxide.

K. Takeuchi, E. Aihara, S. Hayashi, 2011, Pharmacology & therapeutics.

Carbon Monoxide Involved in Modulating HCO3− Secretion in Rat Duodenum

K. Takeuchi, K. Amagase, E. Aihara, 2011, Journal of Pharmacology and Experimental Therapeutics.

Carbon Monoxide Involved in Modulating HCO 3 (cid:1) Secretion in Rat Duodenum

K. Takeuchi, K. Amagase, E. Aihara, 2011 .

Preconditioning Stress Prevents Cold Restraint Stress-Induced Gastric Lesions in Rats: Roles of COX-1, COX-2, and PLA2

K. Takeuchi, A. Tanaka, L. Filaretova, 2007, Digestive Diseases and Sciences.

Orally administered L-arginine and glycine are highly effective against acid reflux esophagitis in rats

K. Takeuchi, M. Yamato, H. Nishio, 2012, Medical science monitor : international medical journal of experimental and clinical research.

Sildenafil, an Inhibitor of Phosphodiesterase Subtype 5, Prevents Indomethacin-Induced Small-Intestinal Ulceration in Rats via a NO/cGMP-Dependent Mechanism

T. Yoshikawa, K. Takeuchi, S. Mitsufuji, 2009, Digestive Diseases and Sciences.

Phosphodiesterase Isozymes Involved in Regulation of \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{HCO}_{3}^{-}\) \end{document} Secretion in Isolated Mouse Stomach in Vitro

K. Takeuchi, Y. Ohashi, E. Aihara, 2008, Journal of Pharmacology and Experimental Therapeutics.

Phosphodiesterase Isozymes Involved in Regulation of HCO 3 Secretion in Isolated Mouse Stomach in Vitro

K. Takeuchi, Y. Ohashi, E. Aihara, 2008 .

Phosphodiesterase isozymes involved in regulation of HCO3- secretion in isolated mouse duodenum in vitro.

K. Takeuchi, Y. Ohashi, M. Hayashi, 2007, Biochemical pharmacology.

Regulatory mechanism of acid secretion in rat stomach after damage-role of nitric oxide, histamine and sensory neurons

K. Takeuchi, S. Kato, 1997, InflammoPharmacology.

Tacrolimus ( FK 506 ) , an Immunosuppressive Agent , Prevents Indomethacin-Induced Small Intestinal Ulceration in the Rat : Inhibition of Inducible Nitric Oxide Synthase Expression

K. Takeuchi, S. Kato, H. Nishio, 2007 .

Tacrolimus (FK506), an immunosuppressive agent, prevents indomethacin-induced small intestinal ulceration in the rat: inhibition of inducible nitric oxide synthase expression.

K. Takeuchi, S. Kato, H. Nishio, 2007, Journal of pharmacological sciences.

Distinct mechanisms of acid-induced HCO3- secretion in normal and slightly permeable stomachs.

K. Takeuchi, E. Aihara, Y. Nomura, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Pathways mediating pentagastrin-induced mucosal blood flow response in rat stomachs

K. Takeuchi, S. Kato, S. Okabe, 1996, Digestive Diseases and Sciences.

Mechanism of gastric alkaline response in the stomach after damage roles of nitric oxide and prostaglandins

K. Takeuchi, S. Okabe, 1995, Digestive Diseases and Sciences.

Role of Endogenous Nitric Oxide and Prostaglandin in Duodenal Bicarbonate Response Induced by Mucosal Acidification in Rats

K. Takeuchi, O. Furukawa, H. Mimaki, 2001, Digestive Diseases and Sciences.

Low Gastric Toxicity of Nitric Oxide-Releasing Aspirin, NCX-4016, in Rats with Cirrhosis and Arthritis

K. Takeuchi, Keizo Suzuki, S. Kato, 2001, Digestive Diseases and Sciences.

Effects of Cyclooxygenase-2 Selective and Nitric Oxide-Releasing Nonsteroidal Antiinflammatory Drugs on Mucosal Ulcerogenic and Healing Responses of the Stomach

K. Takeuchi, S. Kato, H. Yamakuni, 1998, Digestive Diseases and Sciences.

Impaired duodenal bicarbonate secretion in diabetic rats. Salutary effect of nitric oxide synthase inhibitor

K. Takeuchi, R. Korolkiewicz, M. Kubomi, 1997, Journal of Physiology-Paris.

Cytoprotective action of L-arginine against HCl-induced gastric injury in rats: involvement of nitric oxide?

K. Takeuchi, S. Kato, S. Okabe, 1993, Japanese journal of pharmacology.

Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses.

K. Takeuchi, H. Yamamoto, H. Mizoguchi, 1998, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Effect of nitric oxide-releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin.

K. Takeuchi, A. Konaka, Y. Sugawa, 1998, The Journal of pharmacology and experimental therapeutics.

Inhibition of gastric acid secretion by galanin in rats Relation to endogenous histamine release

K. Takeuchi, A. Szyk, P. Rekowski, 1998, Regulatory Peptides.

Association of Genetic Polymorphisms With Afatinib-induced Diarrhoea

Y. Narisawa, S. Kimura, K. Takeuchi, 2020, In Vivo.

H2S-induced HCO3- secretion in the rat stomach--involvement of nitric oxide, prostaglandins, and capsaicin-sensitive sensory neurons.

K. Takeuchi, E. Aihara, S. Hayashi, 2015, Nitric oxide : biology and chemistry.

Importance of cyclooxygenase‐1/prostacyclin in modulating gastric mucosal integrity under stress conditions

K. Takeuchi, K. Amagase, T. Wada, 2014, Journal of gastroenterology and hepatology.

Evaluation of Gastric Ulcerogenic and Healing Impairment Effects of Bisphosphonates: Adverse Gastric Reactions of Bisphosphonate

K. Takeuchi, K. Amagase, 2012, Current protocols in toxicology.

Endogenous prostaglandin E2 accelerates healing of indomethacin‐induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors

K. Takeuchi, K. Amagase, R. Hatazawa, 2010, Journal of gastroenterology and hepatology.

Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.

K. Takeuchi, H. Satoh, A. Tanaka, 2010, Clinica chimica acta; international journal of clinical chemistry.

Involvement of prostacyclin/IP receptors in decreased acid response of damaged stomachs--mediation by somatostatin/SST2 receptors.

K. Takeuchi, H. Nishio, S. Terashima, 2009, Life sciences.

S1625 Effect of Cj-42794, a Selective Antagonist of Prostaglandin E Receptor Subtype 4, On Ulcerogenic and Healing Responses in Rat Gastrointestinal Mucosa

K. Takeuchi, A. Tanaka, S. Kato, 2008 .

Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors.

K. Takeuchi, A. Tanaka, S. Kato, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Impairment of Gastric Ulcer Healing by Alendronate, a Nitrogen-Containing Bisphosphonate, in Rats

K. Takeuchi, K. Amagase, E. Aihara, 2007, Digestive Diseases and Sciences.

Aggravation by Selective COX-1 and COX-2 Inhibitors of Dextran Sulfate Sodium (DSS)-Induced Colon Lesions in Rats

K. Takeuchi, S. Kato, S. Hayashi, 2007, Digestive Diseases and Sciences.

Healing Impairment Effect of Cyclooxygenase Inhibitors on Dextran Sulfate Sodium-Induced Colitis in Rats

K. Takeuchi, S. Kato, S. Hayashi, 2007, Digestion.

Involvement of cyclooxygenase-1, prostaglandin E2 and EP1 receptors in acid-induced HCO3- secretion in stomach.

K. Takeuchi, E. Aihara, Y. Nomura, 2006, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Factors Involved in Upregulation of Inducible Nitric Oxide Synthase in Rat Small Intestine Following Administration of Nonsteroidal Anti-inflammatory Drugs

K. Takeuchi, A. Tanaka, A. Yokota, 2006, Digestive Diseases and Sciences.

Development of intestinal, but not gastric damage caused by a low dose of indomethacin in the presence of rofecoxib

K. Takeuchi, A. Tanaka, A. Yokota, 2006, InflammoPharmacology.

PROSTAGLANDIN E2 AND EP1 RECEPTORS

K. Takeuchi, E. Aihara, Y. Nomura, 2006 .

No Role for Prostacyclin IP Receptors in Duodenal HCO3– Secretion Induced by Mucosal Acidification in Mice – Comparison with Capsaicin-Induced Response

K. Takeuchi, E. Aihara, M. Nakashima, 2004, Digestion.

Induction of Small Intestinal Damage in Rats Following Combined Treatment with Cyclooxygenase-2 and Nitric-Oxide Synthase Inhibitors

K. Takeuchi, A. Tanaka, R. Ohno, 2004, Journal of Pharmacology and Experimental Therapeutics.

Roles of endogenous prostaglandins and cyclooxygenase izoenzymes in mucosal defense of inflamed rat stomach.

M. Murakami, K. Takeuchi, Y. Hayashi, 2004, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Functional Mechanism Underlying COX-2 Expression Following Administration of Indomethacin in Rat Stomachs: Importance of Gastric Hypermotility

K. Takeuchi, Y. Hayashi, A. Tanaka, 2004, Digestive Diseases and Sciences.

Induction of intestinal damage by rofecoxib, the selective COX-2 inhibitor, under inhibition of nitric oxide production in rats

K. Takeuchi, Y. Hayashi, A. Tanaka, 2002, InflammoPharmacology.

NSAID-induced small intestinal damage: role of COX inhibition

K. Takeuchi, A. Tanaka, S. Kato, 2002, InflammoPharmacology.

Cyclooxygenase Isozymes Involved in Adaptive Functional Responses in Rat Stomach after Barrier Disruption

K. Takeuchi, S. Kato, M. Yamato, 2003, Journal of Pharmacology and Experimental Therapeutics.

Prostaglandin E Receptor EP1 Subtype but Not Prostacyclin IP Receptor Involved in Mucosal Blood Flow Response of Mouse Stomachs following Barrier Disruption

K. Takeuchi, M. Nakashima, Akari Nakagiri, 2003, Digestion.

Cyclooxygenase Isozymes Involved in Adaptive Functional Responses in Rat Stomach Following Barrier Disruption

K. Takeuchi, S. Kato, M. Yamato, 2003 .

Role of Cyclooxygenase (COX)-1 and COX-2 Inhibition in Nonsteroidal Anti-Inflammatory Drug-Induced Intestinal Damage in Rats: Relation to Various Pathogenic Events

K. Takeuchi, A. Tanaka, R. Ohno, 2002, Journal of Pharmacology and Experimental Therapeutics.

Gastric ulcerogenic responses following barrier disruption in knockout mice lacking prostaglandin EP1 receptors

K. Takeuchi, S. Kagawa, Y. Ogawa, 2002, Alimentary pharmacology & therapeutics.

Up‐regulation of COX‐2 by inhibition of COX‐1 in the rat: a key to NSAID‐induced gastric injury

K. Takeuchi, A. Tanaka, S. Hase, 2002, Alimentary pharmacology & therapeutics.

Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs

K. Takeuchi, A. Tanaka, S. Hase, 2001, Journal of Physiology-Paris.

Prostaglandin E prevents indomethacin-induced gastric and intestinal damage through different EP receptor subtypes

K. Takeuchi, T. Kunikata, S. Kato, 2001, Journal of Physiology-Paris.

Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice.

K. Takeuchi, S. Kato, H. Araki, 2001, The Journal of pharmacology and experimental therapeutics.

Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E-receptor subtype EP(3).

S. Narumiya, K. Takeuchi, Y. Sugimoto, 1999, Gastroenterology.

Cyclo‐oxygenase isozymes in mucosal ulcerogenic and functional responses following barrier disruption in rat stomachs

K. Takeuchi, S. Kato, H. Yamakuni, 1997, British journal of pharmacology.

Effects of selective cyclooxygenase-2 inhibitors on alkaline secretory and mucosal ulcerogenic responses in rat duodenum.

K. Takeuchi, T. Hirata, H. Ukawa, 1997, Life sciences.

Digest Itself? Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn't the Stomach

J. Wallace, E. Sasaki, K. Tominaga, 2009 .

Oral but Not Parenteral Aspirin Upregulates COX-2 Expression in Rat Stomachs

K. Takeuchi, A. Tanaka, A. Yokota, 2006, Digestion.

Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin.

K. Takeuchi, S. Okabe, S. Yamasaki, 1989, Gastroenterology.

Pathogenic mechanisms involved in mepirizole-induced duodenal damage in the rat.

K. Takeuchi, T. Ohno, S. Okabe, 1986, Japanese journal of pharmacology.

Prophylactic effects of prostaglandin E2 on NSAID-induced enteropathy-role of EP4 receptors in its protective and healing-promoting effects.

K. Takeuchi, 2014, Current opinion in pharmacology.

Prostaglandin E2 stimulates VEGF expression in primary rat gastric fibroblasts through EP4 receptors

K. Takeuchi, A. Tanaka, K. Kamei, 2007, Inflammopharmacology.

Research Article Prostaglandin E 2 stimulates VEGF expression in primary rat gastric fi broblasts through EP4 receptors

K. Takeuchi, A. Tanaka, K. Kamei, 2007 .

Mucosal Ulcerogenic Action of Monochloramine in Rat Stomachs (Effects of Polaprezinc and Sucralfate)

K. Takeuchi, A. Konaka, S. Kato, 1997, Digestive Diseases and Sciences.

Protective effect of Irsogladine on monochloramine induced gastric mucosal lesions in rats:a comparative study with rebamipide.

K. Takeuchi, H. Yamamoto, S. Kato, 1999, World journal of gastroenterology.

Effect of lafutidine, a novel histamine H2‐receptor antagonist, on monochloramine‐induced gastric lesions in rats: Role of capsaicin‐sensitive sensory neurons

K. Takeuchi, M. Umeda, H. Nishiwaki, 1999, Journal of gastroenterology and hepatology.

Dual action of prostaglandin E2 on gastric acid secretion through different EP-receptor subtypes in the rat.

K. Takeuchi, S. Kato, E. Aihara, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Ulcerogenic and healing impairing actions of monochloramine in rat stomachs: effects of zinc L-carnosine, polaprezinc.

K. Takeuchi, S. Kato, T. Yoneta, 1999, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Mechanisms of protective activity of 16,16-dimethyl PGE2 and acetazolamide on gastric and duodenal lesions in rats

K. Takeuchi, S. Okabe, H. Ohtsuki, 1986, Digestive Diseases and Sciences.

Gastroduodenal HCO3-secretion in anesthetized rats: effects of 16,16-dimethyl PGE2, topical acid and acetazolamide.

K. Takeuchi, S. Okabe, H. Tanaka, 1986, Japanese journal of pharmacology.

Pathogenesis of gastric lesions induced by aspirin in the pylorus-ligated rat.

K. Takeuchi, S. Okabe, K. Nakamura, 1974, Japanese journal of pharmacology.

Lithium and haloperidol differentially alter the dynorphin A (1–8) and enkephalin levels in the neurointermediate lobe of rat pituitary

K. Takeuchi, Jau-Shyong Hong, S. Sivam, 1987, Neuropeptides.

Protective Effect of Lactulose on Dextran Sulfate Sodium-Induced Colonic Inflammation in Rats

K. Takeuchi, G. Mózsik, S. Kato, 2004, Digestive Diseases and Sciences.

Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats.

K. Takeuchi, S. Okabe, H. Hirose, 1991, Gastroenterology.

Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in rat brain.

K. Takeuchi, Jau-Shyong Hong, J. Douglass, 1989, Brain research. Molecular brain research.

Repair of mucosal damage induced by ethanol in the rat stomach. Effects of concentration, exposure period and prostaglandins.

S. Ebara, K. Takeuchi, S. Okabe, 1988, Digestion.

A novel model of ischemic enteritis induced in rats by stenosis of the superior mesenteric artery.

K. Takeuchi, T. Kotani, Yoshino Komatsu, 2009, Life sciences.

Gastroprotective role of glucocorticoid hormones.

K. Takeuchi, L. Filaretova, T. Bagaeva, 2007, Journal of pharmacological sciences.

Effects of an antiulcer drug, sucralfate (A basic aluminum salt of sulfated disaccharide), on experimental gastric lesions and gastric secretion in rats

K. Takeuchi, S. Okabe, M. Kanno, 1983, Digestive Diseases and Sciences.

Role of gastric acid and bile acids in the pathogenesis of compound 48/80-induced gastric lesions in rats.

K. Takeuchi, S. Okabe, H. Ohtsuki, 1985, Japanese journal of pharmacology.

[Effects of KT1-32 on acute gastric lesions and duodenal ulcers induced in rats].

K. Takeuchi, S. Okabe, Y. Yamada, 1986, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Novel angucycline compound with both antigastrin- and gastric mucosal protective-activities.

K. Takeuchi, S. Uesato, T. Tokunaga, 1998, Bioorganic & medicinal chemistry letters.

Effects of cimetidine and atropine sulfate on gastric secretion and healing of gastric and duodenal ulcers in rats.

K. Takeuchi, S. Okabe, T. Murata, 1977, European journal of pharmacology.

Inhibition of gastric motor activity by 16, 16-dimethyl prostaglandin E2

K. Takeuchi, Y. Nobuhara, 1985, Digestive Diseases and Sciences.

Management of NSAID/aspirin-induced small intestinal damage by GI-sparing NSAIDs, anti-ulcer drugs and food constituents.

K. Takeuchi, H. Satoh, 2012, Current medicinal chemistry.

Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers

T. Urushidani, K. Takeuchi, S. Okabe, 1977, The American Journal of Digestive Diseases.

Effects of nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester on duodenal alkaline secretory and ulcerogenic responses induced by mepirizole in rats

K. Takeuchi, S. Okabe, T. Ohuchi, 1995, Digestive Diseases and Sciences.

Lack of Gastric Toxicity of Nitric Oxide-Releasing Indomethacin, NCX-530, in Experimental Animals

K. Takeuchi, H. Mizoguchi, Keizo Suzuki, 2001, Digestive Diseases and Sciences.

Role of nitric oxide in regulation of gastric acid secretion in rats: effects of NO donors and NO synthase inhibitor

K. Takeuchi, S. Kato, R. Korolkiewicz, 1998, British journal of pharmacology.

Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Relation to gastric hypermotility.

K. Takeuchi, Y. Fujioka, K. Ueshima, 1991, Digestion.

Less damaging effect of whisky in rat stomachs in comparison with pure ethanol. Role of ellagic acid, the nonalcoholic component.

K. Takeuchi, Y. Kiso, S. Kato, 2001, Digestion.

Role of prostaglandin deficiency in pathogenetic mechanism of gastric lesions induced by indomethacin in rats

K. Takeuchi, S. Okabe, M. Okada, 1989, Digestive Diseases and Sciences.

Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats

K. Takeuchi, S. Okabe, S. Ueki, 1988, Digestive Diseases and Sciences.

Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats

K. Takeuchi, S. Okabe, S. Ueki, 1986, Digestive Diseases and Sciences.

16,16-Dimethyl prostaglandin E2 protects gastric mucosal surface epithelial cells from indomethacin-induced damage in rats.

K. Takeuchi, T. Ohno, S. Okabe, 1987, Japanese journal of pharmacology.

A new model of duodenal ulcers induced in rats by indomethacin plus histamine.

K. Takeuchi, S. Okabe, H. Tanaka, 1986, Gastroenterology.

Effects of carbenoxolone Na on acute and chronic gastric ulcer models in experimental animals

K. Takeuchi, S. Okabe, T. Naganuma, 1976, The American Journal of Digestive Diseases.

Prostaglandin E receptor subtypes involved in stimulation of gastroduodenal bicarbonate secretion in rats and mice.

K. Takeuchi, Y. Sugimoto, F. Ushikubi, 1999, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Gastric mucosal defense and cytoprotection: bench to bedside.

Koji Takeuchi, Loren Laine, L. Laine, 2008, Gastroenterology.

Acetic Acid Ulcer Model – State of the Art in 2012

K. Takeuchi, K. Amagase, S. Okabe, 2012 .

Induction of gastric lesions and hypoglycemic response by food deprivation in streptozotocin-diabetic rats

K. Takeuchi, K. Ueshima, S. Okabe, 1994, Digestive Diseases and Sciences.

Impaired healing of gastric lesions in streptozotocin-induced diabetic rats: effect of basic fibroblast growth factor.

K. Takeuchi, S. Kato, K. Takehara, 1997, The Journal of pharmacology and experimental therapeutics.

Alterations in duodenal bicarbonate secretion and mucosal susceptibility to acid in diabetic rats.

K. Takeuchi, K. Tashima, K. Takehara, 1997, Gastroenterology.

Possible mechanisms involved in gastric hypermotility caused by indomethacin in the rat

K. Takeuchi, S. Okabe, M. Okada, 1990, Digestive Diseases and Sciences.

Role of capsaicin-sensitive afferent neurons in mucosal blood flow response of rat stomach induced by mild irritants

K. Takeuchi, K. Ueshima, S. Okabe, 1992, Digestive Diseases and Sciences.

Endogenous nitric oxide in gastric alkaline response in the rat stomach after damage.

K. Takeuchi, S. Okabe, T. Ohuchi, 1994, Gastroenterology.

A new model of stress ulcer in the rat with pylorus ligation and its pathogenesis

K. Takeuchi, S. Okabe, Keijiro Takagi, 1976, The American Journal of Digestive Diseases.

Effect of ellagic acid on gastric damage induced in ischemic rat stomachs following ammonia or reperfusion.

K. Takeuchi, K. Tashima, Y. Ogawa, 2002, Life sciences.

Phosphodiesterase isozymes involved in regulating acid secretion in the isolated mouse stomach.

T. Yoshikawa, K. Takeuchi, S. Mitsufuji, 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Acid Secretory Changes in Streptozotocin-Diabetic Rats

K. Takeuchi, K. Tashima, M. Nishijima, 2000, Digestive Diseases and Sciences.

Mechanism of Acid Secretory Changes in Rat Stomach After Damage by Taurocholate Role of Nitric Oxide, Histamine, and Sensory Neurons

K. Takeuchi, S. Kato, K. Yagi, 1997, Digestive Diseases and Sciences.

Effects of various agents on prednisolone-induced gastric lesions in rats.

K. Takeuchi, S. Okabe, Y. Nobuhara, 1985, Japanese journal of pharmacology.

Effects of pantoprazole, a novel H+/K+‐ATPase inhibitor, on duodenal ulcerogenic and healing responses in rats: A comparative study with omeprazole and lansoprazole

K. Takeuchi, A. Konaka, S. Kato, 1999, Journal of gastroenterology and hepatology.

Cytoprotective action of histamine against 0.6 N HCl-induced gastric mucosal injury in rats; comparative study with adaptive cytoprotection induced by exogenous acid.

K. Takeuchi, S. Okabe, O. Furukawa, 1987, Japanese journal of pharmacology.

Hypothalamic-pituitary-adrenocortical axis: the hidden gold in gastric mucosal homeostasis

K. Takeuchi, A. Tanaka, L. Filaretova, 2006, InflammoPharmacology.

Antral ulcers induced by alendronate, a nitrogen-containing biphophonate, in rat stomachs - prophylactic effect of rebamipide.

K. Takeuchi, Y. Ohashi, E. Aihara, 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Prophylactic Effect of Irsogladine Maleate Against Indomethacin-Induced Small Intestinal Lesions in Rats

K. Takeuchi, Naho Kato, Y. Kubo, 2008, Digestive Diseases and Sciences.

Gastric mucosal damage induced by compound 48/80: Roles of serotonin and nitric oxide

K. Takeuchi, A. Konaka, S. Kato, 1998, Journal of gastroenterology and hepatology.

Analysis of pathogenic elements involved in gastric lesions induced by non‐steroidal anti‐inflammatory drugs in rats

K. Takeuchi, S. Kato, T. Hirata, 1997, Journal of gastroenterology and hepatology.

Role of nitric oxide in pathogenesis of gastric mucosal damage induced by compound 48 80 in rats

K. Takeuchi, A. Konaka, S. Kato, 1997, Journal of Physiology-Paris.

ANALYSES OF PATHOGENIC ELEMENTS INVOLVED IN GASTRIC LESIONS INDUCED BY INDOMETHACIN IN RATS

K. Takeuchi, S. Kato, K. Takehara, 1997 .

Lack of small intestinal ulcerogenecity of nitric oxide‐releasing indomethacin, NCX‐530, in rats

K. Takeuchi, A. Tanaka, S. Hase, 2001, Alimentary pharmacology & therapeutics.

Effects of sulfhydryl-related compounds on indomethacin-induced gastric lesions in rats: role of endogenous sulfhydryls in the pathogenesis.

K. Takeuchi, K. Ueshima, S. Okabe, 1992, Japanese journal of pharmacology.

Effects of an antiulcer agent N-acetyl-L-glutamine aluminum complex (KW-110) on the duodenal and gastric ulcer models in the rat.

K. Takeuchi, S. Okabe, K. Nakamura, 1974, Japanese journal of pharmacology.

Dopamine D2–Receptor Antagonists Ameliorate Indomethacin-Induced Small Intestinal Ulceration in Mice by Activating α7 Nicotinic Acetylcholine Receptors

K. Takeuchi, N. Yamanaka, S. Kato, 2011 .

TAK-875, an Orally Available G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist, Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats

K. Takeuchi, Masami Suzuki, Y. Momose, 2011, Journal of Pharmacology and Experimental Therapeutics.

Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors.

K. Takeuchi, Kenjiro Matsumoto, S. Kato, 2012, Pharmacological research.

Influence of pregnancy on the development of various gastric lesions in rats

K. Takeuchi, S. Okabe, Keijiro Takagi, 1976, The American Journal of Digestive Diseases.

Effect of L-glutamine on indomethacin-induced gastric lesions in the rat.

K. Takeuchi, S. Okabe, K. Takagi, 1974, Japanese journal of pharmacology.

Pathogenesis of the earliest epithelial cell damage induced by mepirizole and cysteamine in the rat duodenum.

K. Takeuchi, S. Okabe, H. Tanaka, 1989, Japanese journal of pharmacology.

Stimulation of gastroduodenal HCO3- secretion by lubiprostone mediated by different prostaglandin EP receptor subtypes

K. Takeuchi, K. Amagase, S. Hayashi, 2020 .

Stimulation of Gastroduodenal HCO3- Secretion by Lubiprostone in Rats Mediated by Different EP Receptor Subtypes

K. Takeuchi, S. Hayashi, K. Dogishi, 2015 .

Lubiprostone Prevents Nonsteroidal Anti-Inflammatory Drug–Induced Small Intestinal Damage by Suppressing the Expression of Inflammatory Mediators via EP4 Receptors

K. Takeuchi, K. Amagase, Aya Yamaguchi, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Involvement of aquaporin-1 in gastric epithelial cell migration during wound repair.

H. Matsui, K. Takeuchi, S. Kato, 2009, Biochemical and biophysical research communications.

Protective effect of rebamipide on indomethacin‐induced intestinal damage in rats

K. Takeuchi, H. Mizoguchi, A. Tanaka, 2001, Journal of gastroenterology and hepatology.

Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity.

K. Takeuchi, S. Kato, K. Amagase, 2010, Journal of pharmacological sciences.

Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat

K. Takeuchi, S. Okabe, H. Nishiwaki, 1989 .

Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat. Role of enhanced gastric motility.

K. Takeuchi, S. Okabe, H. Nishiwaki, 1989, Gastroenterology.

Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5.

K. Tominaga, Toshio Watanabe, Y. Fujiwara, 2013, European journal of pharmacology.

Rebamipide, a mucoprotective drug, inhibits NSAIDs-induced gastric mucosal injury: possible involvement of the downregulation of 15-hydroxyprostaglandin dehydrogenase

K. Tominaga, Toshio Watanabe, Y. Fujiwara, 2011, Journal of clinical biochemistry and nutrition.

A Questionnaire-Based Survey on the Prescription of Non-Steroidal Anti-Inflammatory Drugs by Physicians in East Asian Countries in 2007

A. Terano, K. Hahm, T. Joh, 2009, Digestion.

Stimulation by nitric oxide synthase inhibitors of gastric and duodenal HCO3- secretion in rats.

K. Takeuchi, S. Okabe, T. Ohuchi, 1993, The Journal of pharmacology and experimental therapeutics.

Protective Effect of Lafutidine, a Novel Histamine H2-Receptor Antagonist, on Dextran Sulfate Sodium-Induced Colonic Inflammation Through Capsaicin-Sensitive Afferent Neurons in Rats

K. Takeuchi, S. Kato, Mitsuaki Okayama, 2004, Digestive Diseases and Sciences.

Protective effect of lafutidine, a novel H2-receptor antagonist, on reflux esophagitis in rats through capsaicin-sensitive afferent neurons.

K. Takeuchi, S. Kato, M. Yamato, 2003, Journal of pharmacological sciences.

Intestinal protection by lafutidine, a histamine H(2)-receptor antagonist, against indomethacin-induced damage in rats--role of endogenous nitric oxide.

K. Takeuchi, A. Tanaka, T. Miyazawa, 2001, Medical science monitor : international medical journal of experimental and clinical research.

Protective Effect of Lafutidine against Indomethacin-Induced Intestinal Ulceration in Rats: Relation to Capsaicin-Sensitive Sensory Neurons

K. Takeuchi, T. Kunikata, A. Tanaka, 2000, Digestion.

Mucosal Protection by l -Arginine in the Upper Gastrointestinal Tract

K. Takeuchi, 2017 .

Alteration of gastric ulcerogenic and healing responses in rats with adjuvant-induced arthritis.

K. Takeuchi, S. Kato, 2002, Japanese journal of pharmacology.

Delayed Healing of Gastric Ulcers in Adjuvant Arthritis Rats: Role of Acid Secretion and Basic Fibroblast Growth Factor

K. Takeuchi, T. Kunikata, A. Tanaka, 2001, Digestion.

Essential Role of Pepsin in Pathogenesis of Acid Reflux Esophagitis in Rats

K. Takeuchi, M. Yamato, H. Nishio, 2006, Digestive Diseases and Sciences.

Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats.

K. Takeuchi, A. Konaka, T. Kunikata, 1999, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Gastric Motility and Mucosal Ulcerogenic Responses Induced by Rats Under Prostaglandin-Deficient Conditions Prokinetic Drugs in

K. Takeuchi, S. Kato, T. Hirata, 1997, Digestive Diseases and Sciences.

Gastric motility and mucosal ulcerogenic responses induced by prokinetic drugs in rats under prostaglandin-deficient conditions.

K. Takeuchi, S. Kato, T. Hirata, 1997 .

Vinegar is a dietary mild irritant to the rat gastric mucosa.

K. Takeuchi, S. Okabe, Y. Nobuhara, 1986, Japanese journal of pharmacology.

Impairment by allyl isothiocyanate of gastric epithelial wound repair through inhibition of ion transporters.

H. Matsui, K. Takeuchi, A. Yamaguchi, 2008, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid.

K. Tominaga, Toshio Watanabe, Y. Fujiwara, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.

J. Yano, K. Aertgeerts, K. Takeuchi, 2011, Bioorganic & medicinal chemistry.

Roles of gastric motility changes in cytoprotection induced by acetazolamide and cysteamine in rats.

K. Takeuchi, Y. Ishihara, S. Okabe, 1987, Japanese journal of pharmacology.

Effect of (S)-4-(1-(5-Chloro-2-(4-fluorophenyoxy)benzamido)ethyl) Benzoic Acid (CJ-42794), a Selective Antagonist of Prostaglandin E Receptor Subtype 4, on Ulcerogenic and Healing Responses in Rat Gastrointestinal Mucosa

K. Takeuchi, A. Tanaka, S. Kato, 2007, Journal of Pharmacology and Experimental Therapeutics.

EP4 receptor mediation of prostaglandin E2-stimulated mucus secretion by rabbit gastric epithelial cells.

K. Takeuchi, S. Takahashi, S. Okabe, 1999, Biochemical pharmacology.

Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility.

Koji Takeuchi, K. Takeuchi, 2012, World journal of gastroenterology.

The absence of uPAR attenuates insulin-induced vascular smooth muscle cell migration and proliferation.

K. Takeuchi, K. Okada, O. Matsuo, 2008, Thrombosis research.

Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1.

K. Takeuchi, M. Murano, E. Umegaki, 2010, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Advances in gastrointestinal nutrient sensor research: nutritional pharmacy for elderly health fundamentals.

H. Uneyama, K. Takeuchi, 2011, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

New frontiers in gut nutrient sensor research--from taste physiology to gastroenterology: preface.

H. Uneyama, K. Takeuchi, 2010, Journal of pharmacological sciences.

Pathogenesis of compound 48/80-induced gastric lesions in rats

K. Takeuchi, S. Okabe, H. Ohtsuki, 1986, Digestive Diseases and Sciences.

Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum.

K. Takeuchi, K. Ueshima, S. Okabe, 1991, Gastroenterology.

Determination of gastroduodenal alkaline responses in the rat.

K. Takeuchi, K. Ueshima, H. Niida, 1990, Journal of pharmacological methods.

Determination of bicarbonate output using pH deflection in the rat duodenum: influences of prostaglandins and cholinergic agents.

M. Minami, K. Takeuchi, S. Okabe, 1990, Japanese journal of pharmacology.

Effect of dopamine on the healing of acetic acid-induced gastric ulcers in rats

K. Takeuchi, K. Amagase, K. Nishikawa, 2007, Inflammopharmacology.

Effects of dopamine on gastric mucosal lesions induced by ethanol in rats

K. Takeuchi, S. Okabe, H. Nishiwaki, 1988, Digestive Diseases and Sciences.

Effects of gastric distension and prostaglandin on acid ethanol-induced mucosal lesions in the rat

K. Takeuchi, N. Hara, S. Okabe, 1988, Digestive Diseases and Sciences.

Mechanism by which histamine increases gastric mucosal blood flow in the rat

K. Takeuchi, S. Kato, S. Okabe, 1993, Digestive Diseases and Sciences.

Role of local motility changes in the pathogenesis of duodenal ulcers induced by cysteamine in rats

K. Takeuchi, S. Okabe, H. Nishiwaki, 1987, Digestive Diseases and Sciences.

Role of luminal alkalinization in repair process of ethanol-induced mucosal damage in rat stomach

K. Takeuchi, S. Okabe, 1983, Digestive Diseases and Sciences.

Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice.

K. Takeuchi, H. Isayama, Masanori Yoshida, 2007, Journal of pharmacological sciences.

Risperidone Attenuates Local and Systemic Inflammatory Responses to Ameliorate Diet-Induced Severe Necrotic Pancreatitis in Mice: It May Provide a New Therapy for Acute Pancreatitis

K. Takeuchi, H. Isayama, Masanori Yoshida, 2009, Journal of Pharmacology and Experimental Therapeutics.

Role of the sympathetic nervous system in gastric functional changes induced by thyrotropin-releasing hormone in rats.

K. Takeuchi, S. Okabe, M. Tachibana, 1995, Japanese journal of pharmacology.

The Role of Food Intake on Gastric Mucosal Growth and Gastrin Receptors during Pregnancy and Lactation 1

K. Takeuchi, L. Johnson, 1987, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Acid secretory and duodenal ulcerogenic responses induced by mepirizole in anesthetized rats

K. Takeuchi, K. Ueshima, S. Okabe, 1994, Digestive Diseases and Sciences.

Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent

K. Tominaga, Toshio Watanabe, Y. Fujiwara, 2007, Gut.

Characterization of FPL-52694 [5-(2-hydroxypropoxyl)-8-propyl-4-oxo-4H-benzopyran-2-carboxylic acid Na] on histamine release from rat peritoneal mast cells induced by antigen, compound 48/80 and A 23187

K. Takeuchi, S. Okabe, S. Nakagawa, 1985, Agents and Actions.

Importance of pepsin and stomach distension in morphological alterations of stress-induced gastric lesions in pylorus-ligated rats

K. Takeuchi, S. Okabe, 2005, Digestive Diseases and Sciences.

A novel gastric lesion model induced in rats by partial gastric vascular ligation

K. Takeuchi, K. Amagase, S. Okabe, 2006, InflammoPharmacology.

Effects of indomethacin on the duodenal mucosa of rats: comparative study with cysteamine.

K. Takeuchi, S. Okabe, H. Tanaka, 1986, Japanese journal of pharmacology.

Lafutidine Protects the NSAID-Induced Small Intestinal Lesions Mediated by Capsaicin-Sensitive Afferent Neurons

K. Takeuchi, K. Amagase, 2014 .

Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen‐induced small intestinal lesions in rats

K. Takeuchi, S. Kato, K. Amagase, 2010, Journal of gastroenterology and hepatology.

Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.

J. Yano, K. Aertgeerts, K. Takeuchi, 2011, Journal of medicinal chemistry.

Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism

H. Ueno, K. Takeuchi, Lihong Shi, 2016, PloS one.

Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys.

D. Kassel, K. Takeuchi, Lihong Shi, 2008, European journal of pharmacology.

Inhibitory effect ofl-glutamine on gastric irritation and back diffusion of gastric acid in response to aspirin in the rat

K. Takeuchi, K. Honda, S. Okabe, 1975, The American Journal of Digestive Diseases.

Effect of polaprezinc on impaired healing of chronic gastric ulcers in adjuvant-induced arthritic rats--role of insulin-like growth factors (IGF)-1.

T. Yoneda, K. Takeuchi, A. Tanaka, 2001, Medical science monitor : international medical journal of experimental and clinical research.

Bicarbonate stimulatory action of nizatidine, a histamine H2-receptor antagonist, in rat duodenums

K. Takeuchi, S. Kagawa, S. Kawauchi, 2001, Journal of Physiology-Paris.

Stimulation by nitric oxide of HCO3- secretion in bullfrog duodenum in vitro--roles of cyclooxygenase-1 and prostaglandins.

K. Takeuchi, O. Furukawa, S. Kawauchi, 2000, Medical science monitor : international medical journal of experimental and clinical research.

Roles of nitric oxide (NO) and NO synthases in healing of dextran sulfate sodium-induced rat colitis.

K. Takeuchi, S. Kato, H. Nishio, 2008, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

K. Takeuchi, K. Ogi, Hideyuki Tanaka, 2009, Diabetes.

Role of capsaicin-sensitive afferent neurons in receptive relaxation induced by gastric distension in rats

Y. Matsuzaka, K. Takeuchi, S. Kato, 2007, Inflammopharmacology.

Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine.

K. Tominaga, Toshio Watanabe, Y. Fujiwara, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Lithium increases dynorphin A(1-8) and prodynorphin mRNA levels in the basal ganglia of rats.

J. McGinty, K. Takeuchi, J. Douglass, 1988, Brain research.

Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats

K. Takeuchi, K. Amagase, E. Hashimoto, 2014, Journal of gastroenterology and hepatology.

Animal Model for Evaluating Gastric Bleeding and Ulcerogenic Response Induced by Aspirin plus Clopidogrel

K. Takeuchi, S. Takayama, Y. Yoshida, 2012 .

Aggravation by Paroxetine, a Selective Serotonin Reuptake Inhibitor, of Antral Lesions Generated by Nonsteroidal Anti-Inflammatory Drugs in Rats

K. Takeuchi, A. Tanaka, K. Amagase, 2011, Journal of Pharmacology and Experimental Therapeutics.

Prophylactic effect of rebamipide against the irritative and healing impairment actions of alendronate in rat stomachs

K. Takeuchi, S. Kato, K. Amagase, 2007, Inflammopharmacology.

Less Damaging Effect of Whisky in Rat Stomachs in Comparison with Pure Ethanol

K. Takeuchi, Y. Kiso, S. Kato, 2001, Digestion.

Determination of acid-neutralizing capacity in rat duodenum

K. Takeuchi, Hironori Tanaka, S. Okabe, 1986, Digestive Diseases and Sciences.

Effects of antacid, antipeptic and anticholinergic agents on the development and healing of duodenal ulcers in the rat.

K. Takeuchi, S. Okabe, K. Nakamura, 1974, Digestion.

Cyclooxygenase (COX)-1 and COX-2 Both Play an Important Role in the Protection of the Duodenal Mucosa in Cats

S. Ebara, K. Takeuchi, H. Satoh, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Gastric HCO3− secretion induced by mucosal acidification: Different mechanisms depending on acid concentration

K. Takeuchi, E. Aihara, Y. Sasaki, 2006, InflammoPharmacology.

Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum

K. Takeuchi, Hironori Tanaka, S. Okabe, 1988, Digestive Diseases and Sciences.

Possible role of endogenous prostaglandins in alkaline response in rat gastric mucosa damaged by hypertonic NaCl

K. Takeuchi, Y. Nobuhara, 1984, Digestive Diseases and Sciences.

Changes in transmucosal potential difference and luminal pH in anesthetized rat stomach after exposure to ethanol.

K. Takeuchi, S. Okabe, Y. Nobuhara, 1983, Japanese journal of pharmacology.

16,16-Dimethyl prostaglandin E2 aggravates gastric mucosal injury induced by histamine in rats. Possible role of the increased mucosal vascular permeability.

K. Takeuchi, S. Okabe, O. Furukawa, 1987, Gastroenterology.

Role of accumulated gastric content in the pathogenesis of cysteamine‐ and mepirizole‐induced duodenal ulcers in the rat

K. Takeuchi, H. Tanaka, S. Okabe, 1990, Journal of internal medicine. Supplement.

The relationship of intraduodenal pH and delayed gastric emptying in duodenal ulceration induced by mepirizole or cysteamine in rats.

K. Takeuchi, S. Okabe, H. Tanaka, 1989, Japanese journal of pharmacology.

Effects of 15(S)-15-methyl-PGE2 methyl ester on healing of chronic gastric and duodenal ulcers in rats.

K. Takeuchi, S. Okabe, A. Ishibashi, 1979, Japanese journal of pharmacology.

Histamine-induced villous damage in the rat duodenum.

K. Takeuchi, S. Okabe, H. Tanaka, 1989, Japanese journal of pharmacology.

Gastric acid secretion in streptozotocin-diabetic rats – Different responses to various secretagogues

K. Takeuchi, K. Tashima, M. Nishijima, 2000, Journal of Physiology-Paris.

Mechanisms Underlying Capsaicin-Stimulated \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{HCO}_{3}^{-}\) \end{document} Secretion in the Stomach: Comparison with Mucosal Acidificat

K. Takeuchi, E. Aihara, A. Kobata, 2005, Journal of Pharmacology and Experimental Therapeutics.

Stimulation by Capsaicin of Duodenal HCO3− Secretion via Afferent Neurons and Vanilloid Receptors in Rats: Comparison with Acid-Induced HCO3− Response

K. Takeuchi, S. Kagawa, M. Aoi, 2003, Digestive Diseases and Sciences.

Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats.

T. Hibi, H. Ishii, K. Takeuchi, 2004, Biochemical and biophysical research communications.

Effects of topical application of KT1-32 on transmucosal potential difference and acid secretion in the rat stomach.

K. Takeuchi, S. Okabe, A. Tomiyama, 1990, Japanese journal of pharmacology.

Effects of various amino acids on indomethacin-induced gastric ulcers in rats.

T. Urushidani, K. Takeuchi, S. Okabe, 1977, Japanese journal of pharmacology.

Increased Microvascular Permeability and Lesion Formation During Gastric Hypermotility Caused by Indomethacin and 2‐Deoxy‐D‐Glucose in the Rat

S. Ebara, K. Takeuchi, M. Okada, 1990, Journal of clinical gastroenterology.

Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice.

K. Takeuchi, S. Kato, K. Amagase, 2011, European journal of pharmacology.

Dual role of endogenous nitric oxide in development of dextran sulfate sodium-induced colitis in rats

K. Takeuchi, G. Mózsik, S. Kato, 2004 .

Dual role of endogenous nitric oxide in development of dextran sodium sulfate-induced colitis in rats.

K. Takeuchi, G. Mózsik, S. Kato, 2004, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Role of Nitric Oxide in Pathogenesis of Aspirin-Induced Gastric Mucosal Damage in Rats

K. Takeuchi, Y. Asada, Y. Sugawa, 1998, Digestion.

Effects of metiamide and propranolol on gastric secretion in anesthetized dogs.

K. Takeuchi, S. Okabe, C. Hung, 1977, Japanese journal of pharmacology.

Chronic Administration of Voglibose, an α-Glucosidase Inhibitor, Increases Active Glucagon-Like Peptide-1 Levels by Increasing Its Secretion and Decreasing Dipeptidyl Peptidase-4 Activity in ob/ob Mice

K. Takeuchi, Y. Moritoh, M. Hazama, 2009, Journal of Pharmacology and Experimental Therapeutics.

Effects of no-releasing aspirin on functional and mucosal ulcerogenic responses in the rat stomach: Comparison with aspirin

K. Takeuchi, A. Tanaka, H. Yamamoto, 1998 .

Nitric oxide and prostaglandins in regulation of acid secretory response in rat stomach following injury.

K. Takeuchi, S. Okabe, T. Kaneko, 1995, The Journal of pharmacology and experimental therapeutics.

A continuous monitoring of mucosal integrity and secretory activity in rat stomach: a preparation using a lucite chamber.

K. Takeuchi, Y. Ishihara, S. Okabe, 1989, Japanese journal of pharmacology.

Endogenous prostaglandins in gastric alkaline response in the rat stomach after damage.

K. Takeuchi, H. Tanaka, S. Ueki, 1986, The American journal of physiology.

Cinacalcet, a calcimimetic, prevents nonsteroidal antiinflammatory drug-induced small intestinal damage in rats.

K. Takeuchi, K. Amagase, S. Hayashi, 2013, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Roles of Cyclooxygenase, Prostaglandin E2 and EP Receptors in Mucosal Protection and Ulcer Healing in the Gastrointestinal Tract.

K. Takeuchi, K. Amagase, 2018, Current pharmaceutical design.

Prostaglandin EP receptors and their roles in mucosal protection and ulcer healing in the gastrointestinal tract.

K. Takeuchi, 2010, Advances in clinical chemistry.

Contribution of Glucocorticoids to Protective Influence of Preconditioning Mild Stress against Stress‐induced Gastric Erosions

K. Takeuchi, K. Amagase, L. Filaretova, 2008, Annals of the New York Academy of Sciences.

Effect of Ecabet Disodium, a Novel Locally-Acting Antiulcer Drug, on Epithelial Restitution following Injury by Hypertonic NaCl in Bullfrog Stomach in vitro

K. Takeuchi, E. Kume, O. Furukawa, 2000, Digestion.

Role of sulfhydryls in mucosal injury caused by ethanol: relation to microvascular permeability, gastric motility and cytoprotection.

K. Takeuchi, S. Okabe, M. Okada, 1989, The Journal of pharmacology and experimental therapeutics.

Stimulation of gastric alkaline secretion by histamine in rats: possible involvement of histamine H2-receptors and endogenous prostaglandins.

K. Takeuchi, S. Okabe, H. Tanaka, 1989, The Journal of pharmacology and experimental therapeutics.

Participation of prostaglandin E receptor EP4 subtype in duodenal bicarbonate secretion in rats.

K. Takeuchi, E. Aihara, M. Nakashima, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Facilitation by Endogenous Prostaglandins of Capsaicin-Induced Gastric Protection in Rodents through EP2 and IP Receptors

K. Takeuchi, S. Kato, M. Matsumoto, 2003, Journal of Pharmacology and Experimental Therapeutics.

Protection by aspirin of indomethacin-induced small intestinal damage in rats: mediation by salicylic acid

K. Takeuchi, H. Mizoguchi, A. Tanaka, 2001, Journal of Physiology-Paris.

COX and NOS isozymes involved in duodenal bicabonate response induced by mucosal acidificaton in rats

K. Takeuchi, A. Tanaka, S. Kagawa, 2001 .

Gastric motility changes in capsaicin-induced cytoprotection in the rat stomach.

K. Takeuchi, K. Ueshima, S. Okabe, 1991, Japanese journal of pharmacology.

Effects of cimetidine on healing of chronic gastric and duodenal ulcers in dogs

T. Urushidani, K. Takeuchi, S. Okabe, 1978, The American Journal of Digestive Diseases.

Stimulation of duodenal HCO3− secretion by hydrogen sulphide in rats: relation to prostaglandins, nitric oxide and sensory neurones

K. Takeuchi, E. Aihara, S. Hayashi, 2011, Acta physiologica.

Strain differences in aspirin-induced gastric ulceration in rats.

T. Urushidani, K. Takeuchi, S. Okabe, 1978, Japanese journal of pharmacology.

Impairment by 5-Fluorouracil of the Healing of Gastric Lesions in Rats: Effect of Lafutidine, a Histamine H2 Receptor Antagonist, Mediated by Capsaicin-Sensitive Afferent Neurons

K. Takeuchi, K. Amagase, S. Hayashi, 2008, Digestive Diseases and Sciences.

Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins.

K. Takeuchi, S. Kato, Y. Aoi, 2006, World journal of gastroenterology.

Effect of Lafutidine, a Histamine H2-Receptor Antagonist, on Gastric Mucosal Blood Flow and Duodenal HCO3− Secretion in Rats: Relation to Capsaicin-Sensitive Afferent Neurons

K. Kohama, K. Takeuchi, S. Kato, 2002, Digestive Diseases and Sciences.

Body temperature dependency in baclofen-induced gastric acid secretion in rats relation to capsaicin-sensitive afferent neurons.

K. Takeuchi, S. Kato, H. Araki, 2001, Life Science.

Increased susceptibility of rat gastric mucosa to ulcerogenic stimulation with aging

K. Takeuchi, S. Kato, N. Inaba, 1996, Digestive Diseases and Sciences.

Less Irritative Action of Wine and Japanese Sake in Rat Stomachs: A Comparative Study with Ethanol

K. Takeuchi, S. Kato, Akari Nakagiri, 2006, Digestive Diseases and Sciences.

Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock: comparative study with indomethacin.

K. Takeuchi, S. Okabe, H. Tanaka, 1987, Japanese journal of pharmacology.

Induction of duodenal ulcers in rats under water-immersion stress conditions. Influence of stress on gastric acid and duodenal alkaline secretion.

K. Takeuchi, S. Okabe, O. Furukawa, 1986, Gastroenterology.

Acid back-diffusion and mucosal H+ handling in the rat stomach under normal and stress-induced conditions.

K. Takeuchi, S. Okabe, 1983, Japanese Journal of Pharmacology.

Stimulation of duodenal bicarbonate secretion by carbenoxolone in rats: a comparative study with prostaglandin E2.

K. Takeuchi, M. Kubomi, K. Yagi, 1998, General pharmacology.

Pathogenic importance of pepsin in ischemia/reperfusion-induced gastric injury.

K. Takeuchi, K. Amagase, A. Kobata, 2007, Life sciences.

Effects of L-glutamine of acetylsalicylic acid or taurocholic acid-induced gastric lesions and secretory changes in pylorus-ligated rats under normal or stress conditions.

K. Takeuchi, S. Okabe, C. Hung, 1976, Japanese journal of pharmacology.

Role of capsaicin-sensitive sensory nerves in acid-induced bicarbonate secretion in rat stomach

K. Takeuchi, K. Ueshima, S. Okabe, 1992, Digestive Diseases and Sciences.

Characterization of gastric mucosal blood flow response induced by intragastric capsaicin in rats.

K. Takeuchi, S. Okabe, J. Matsumoto, 1991, Japanese journal of pharmacology.

Gastric acid secretion and lesion formation in rats under water-immersion stress

K. Takeuchi, M. Hayase, 1986, Digestive Diseases and Sciences.

Vagally mediated acid hypersecretion and lesion formation in anesthetized rat under hypothermic conditions

K. Takeuchi, K. Ueshima, S. Okabe, 1991, Digestive Diseases and Sciences.

Inhibitory effects of L‐glutamine on the aspirin‐induced gastric lesions in the rat

K. Takeuchi, S. Okabe, K. Nakamura, 1974, The Journal of pharmacy and pharmacology.

Nitric oxide, prostaglandin, and sensory neurons in gastric mucosal blood flow response during acid secretion in rats.

K. Takeuchi, S. Kato, T. Hirata, 1997, General pharmacology.

Mechanism of gastric hyperemic response during acid secretion in rats: relation to nitric oxide, prostaglandins, and sensory neurons.

K. Takeuchi, S. Kato, Y. Abe, 1997, Journal of clinical gastroenterology.

Mechanisms Underlying the Gastroprotective Action of Glucocorticoids Released in Response to Ulcerogenic Stress Factors

K. Takeuchi, A. Tanaka, L. Filaretova, 2004, Annals of the New York Academy of Sciences.

Inhibitory influence of ligation of the small intestine on gastric secretion in the pylorus-ligated rats

K. Takeuchi, H. Hayashi, K. Nakamura, 1973, Experientia.

PACAPs stimulate duodenal bicarbonate secretion at PACAP receptors in the rat.

K. Takeuchi, S. Kato, K. Takehara, 1997, The American journal of physiology.

Mechanisms underlying stimulation of gastroduodenal HCO3- secretion by NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, in rats.

K. Takeuchi, S. Okabe, K. Takehara, 1994, Japanese journal of pharmacology.

Characterization of alkaline response induced by cholinergic agents in the rat duodenum: involvement of M2 receptors and the calcium-dependent process.

K. Takeuchi, S. Okabe, H. Niida, 1990, The Journal of pharmacology and experimental therapeutics.

Irritative and protective activity of mild irritants in rat stomach

K. Takeuchi, T. Ohno, S. Okabe, 1987, Digestive Diseases and Sciences.

Functional and morphological alterations in the rat stomach following exposure to hypertonic NaCl solution.

K. Takeuchi, S. Okabe, H. Yamakuni, 1986, Japanese Journal of Pharmacology.

Pathogenic Importance of Cysteinyl Leukotrienes in Development of Gastric Lesions Induced by Ischemia/Reperfusion in Mice

K. Takeuchi, S. Kojima, T. Kotani, 2010, Journal of Pharmacology and Experimental Therapeutics.

Microsoft Word-22231661-file00

K. Takeuchi, S. Kojima, T. Kotani, 2009 .

Dual Action of Nitric Oxide in the Pathogenesis of Ischemia/Reperfusion-Induced Mucosal Injury in Mouse Stomach

K. Takeuchi, S. Kato, K. Amagase, 2007, Digestion.

Roles of Cyclooxygenase-2 and Prostacyclin/IP Receptors in Mucosal Defense against Ischemia/Reperfusion Injury in Mouse Stomach

K. Takeuchi, K. Amagase, E. Nakamura, 2006, Journal of Pharmacology and Experimental Therapeutics.

Roles of COX-2 and Prostacyclin / IP Receptors in Mucosal Defense against Ischemia / Reperfusion Injury in Mouse Stomach

K. Takeuchi, K. Amagase, E. Nakamura, 2005 .

Exacerbation of Nonsteroidal Anti-Inflammatory Drug-Induced Small Intestinal Lesions by Antisecretory Drugs in Rats: The Role of Intestinal Motility

K. Takeuchi, H. Satoh, K. Amagase, 2012, Journal of Pharmacology and Experimental Therapeutics.

Effects of pituitary adenylate cyclase activating polypeptide-27 on alkaline secretory and mucosal ulcerogenic responses in rat duodenum.

K. Takeuchi, K. Takehara, K. Yagi, 1998, Life sciences.

Stimulatory effect of Coca-ColaTM on gastroduodenal HCO3− secretion in rats

K. Takeuchi, E. Aihara, Y. Sasaki, 2007, Inflammopharmacology.

Effects of prostaglandin biosynthesis inhibitors and ouabain on duodenal mucosa and HCO3- secretion in rats.

K. Takeuchi, S. Okabe, O. Furukawa, 1987, Japanese journal of pharmacology.

Dual effects ofN-ethylmaleimide on ethanol-induced gastric lesions in rats

K. Takeuchi, S. Okabe, M. Okada, 1991, Digestive Diseases and Sciences.

Capsaicin-sensitive sensory nerves in recovery of gastric mucosal integrity after damage by sodium taurocholate in rats.

K. Takeuchi, S. Okabe, T. Ohuchi, 1993, Japanese journal of pharmacology.

Capsaicin-sensitive afferent neurons in adaptive responses of the rat stomach induced by a mild irritant.

K. Takeuchi, K. Ueshima, S. Okabe, 1991, Japanese journal of pharmacology.

Prostaglandin EP receptor subtypes and gastric cytoprotection

K. Takeuchi, A. Yokota, S. Hase, 2002, InflammoPharmacology.

Bile salts are endogenous mild irritants to rat gastric mucosa.

K. Takeuchi, 1984 .

Irritative action of alcoholic beverages in rat stomachs: A comparative study with ethanol

K. Takeuchi, S. Kato, Akari Nakagiri, 2006, InflammoPharmacology.

Role of endogenous prostacyclin in gastric ulcerogenic and healing responses—a study using IP-receptor knockout mice

K. Takeuchi, S. Kato, K. Kanatsu, 2001, Journal of Physiology-Paris.

Dissolution of antisecretory and cytoprotective action of PGE2 in rats.

K. Takeuchi, S. Okabe, J. Y. Wang, 1988, Japanese journal of pharmacology.

A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure.

K. Takeuchi, Y. Moritoh, N. Suzuki, 2009, Life sciences.

Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection.

H. Matsui, K. Kohama, A. Nakamura, 2003, Biochemical pharmacology.

The increased mucosal mRNA expressions of complement C3 and interleukin‐17 in inflammatory bowel disease

K. Takeuchi, A. Andoh, Y. Fujiyama, 2010, Clinical and experimental immunology.

Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV.

D. Kassel, S. L. Gwaltney, K. Takeuchi, 2007, Journal of medicinal chemistry.

HSP70 Confers Protection against Indomethacin-Induced Lesions of the Small Intestine

G. Sobue, H. Goto, K. Takeuchi, 2009, Journal of Pharmacology and Experimental Therapeutics.

Cytoprotective action of mast cell stabilizers against ethanol-induced gastric lesions in rats.

K. Takeuchi, S. Okabe, H. Nishiwaki, 1986, Japanese journal of pharmacology.

Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats.

K. Takeuchi, K. Tashima, M. Umeda, 2000, Life sciences.

Stimulatory Effect of Nitric Oxide on Bicarbonate Secretion in Bullfrog Duodenums in vitro

K. Takeuchi, O. Furukawa, S. Sugamoto, 1999, Digestion.

Compensatory gastroprotective role of glucocorticoid hormones during inhibition of prostaglandin and nitric oxide production and desensitization of capsaicin-sensitive sensory neurons

K. Takeuchi, L. Filaretova, T. Bagaeva, 2007, Inflammopharmacology.

Gastrointestinal sparing anti-inflammatory drugs--effects on ulcerogenic and healing responses.

K. Takeuchi, H. Mizoguchi, A. Tanaka, 2001, Current pharmaceutical design.

Chapter 5 Modulation of Capsaicin-Induced Gastric Protection by Endogenous Prostaglandins through EP 2 / IP Receptors

K. Takeuchi, 2017 .

Modulation of Capsaicin-Induced Gastric Protection by Endogenous Prostaglandins through EP2/IP Receptors

K. Takeuchi, 2014 .

The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach

K. Takeuchi, H. Araki, Y. Sugawa, 2000, Alimentary pharmacology & therapeutics.

Regulatory mechanisms of acid secretory responses in the damaged stomach.

K. Takeuchi, S. Kato, S. Kagawa, 2002 .

Interactive roles of endogenous prostaglandin and nitric oxide in regulation of acid secretion by damaged rat stomachs

K. Takeuchi, H. Yamamoto, K. Tashima, 2000, Alimentary pharmacology & therapeutics.

Modulation by endogenous nitric oxide of acid secretion induced by gastric distention in rats: enhancement by nitric oxide synthase inhibitor.

K. Takeuchi, S. Kato, S. Kawauchi, 1999, The Journal of pharmacology and experimental therapeutics.

Gastric hyperemic response during vagally mediated acid secretion by TRH analog in rats.

K. Takeuchi, S. Kato, T. Hirata, 1997, The Journal of pharmacology and experimental therapeutics.

Dual role of nitric oxide in gastric hypersecretion in the distended stomach: inhibition of acid secretion and stimulation of pepsinongen secretion.

T. Yoshikawa, K. Takeuchi, S. Mitsufuji, 2008, Life sciences.

Desensitization of capsaicin-sensitive sensory neurons in rat stomachs on chronic treatment with sodium taurocholate.

K. Takeuchi, S. Takahashi, S. Okabe, 1995, Japanese journal of pharmacology.

Regulatory mechanism of acid secretion in the damaged stomach: Role of endogenous nitric oxide

K. Takeuchi, H. Mizoguchi, T. Kunikata, 2000, Journal of gastroenterology and hepatology.

Body temperature-dependent action of baclofen in rat stomach

K. Takeuchi, S. Okabe, H. Nishiwaki, 1990, Digestive Diseases and Sciences.

Induction of gastric lesions by 2-deoxy-D-glucose in rats following chemical ablation of capsaicin-sensitive sensory neurons.

K. Takeuchi, K. Ueshima, S. Okabe, 1992, Japanese journal of pharmacology.

Influence of the proximal small intestine on the gastric hypersecretion in pylorus-ligated rats

K. Takeuchi, S. Okabe, Keita Nakamura, 1975, The American Journal of Digestive Diseases.

COX inhibition and NSAID-induced gastric damage--roles in various pathogenic events.

K. Takeuchi, Y. Hayashi, A. Tanaka, 2005, Current Topics in Medicinal Chemistry.

Genetic Evidence for a Protective Role of Heat Shock Factor 1 against Irritant-Induced Gastric Lesions

Takaaki Ito, K. Takeuchi, A. Nakai, 2007, Molecular Pharmacology.

Mucosal protective action of histamine against gastric lesions induced by HCl in rats: importance of antigastric motor activity mediated by H2-receptors.

K. Takeuchi, S. Okabe, H. Nishiwaki, 1988, Journal of Pharmacology and Experimental Therapeutics.

Different effects of cytoprotective drugs on ethanol- and aspirin-induced gastric mucosal injury in pylorus-ligated rats

K. Takeuchi, S. Okabe, H. Nishiwaki, 1990, Digestive Diseases and Sciences.

Mechanisms involved in aggravation of ethanol-induced gastric mucosal lesions in adrenalectomized rats.

K. Takeuchi, N. Hara, S. Okabe, 1989, Japanese journal of pharmacology.

Isothiocyanate Inhibits Restitution and Wound Repair after Injury in the Stomach: Ex Vivo and in Vitro Studies

K. Takeuchi, S. Yanaka, E. Nakamura, 2007, Journal of Pharmacology and Experimental Therapeutics.

Induction of duodenal ulcers in sensory deafferented rats following histamine infusion.

K. Takeuchi, K. Ueshima, S. Okabe, 1992, Digestion.

Roles of Up-Regulated Expression of ASIC3 in Sex Difference of Acid-Induced Duodenal HCO3- Responses.

K. Takeuchi, Y. Ohashi, K. Amagase, 2020, Current pharmaceutical design.

Capsaicin-sensitive sensory neurons in healing gastric lesions induced by HCl in rats

K. Takeuchi, S. Okabe, T. Ohuchi, 1994, Digestive Diseases and Sciences.

Lithium increases rat striatal beta- and gamma-preprotachykinin messenger RNAs.

J. McGinty, K. Takeuchi, J. Krause, 1989, The Journal of pharmacology and experimental therapeutics.

Duodenal ulcers induced by diethyldithiocarbamate, a superoxide dismutase inhibitor, in the rat: role of antioxidative system in the pathogenesis.

K. Takeuchi, K. Ueshima, S. Okabe, 1991, Japanese journal of pharmacology.

Voglibose, an Alpha-glucosidase Inhibitor, to Increase Active Glucagon-like Peptide-1 Levels

K. Takeuchi, Y. Moritoh, M. Hazama, 2009 .

Protective Effect of Intra-Rectal Administration of Rebamipide on Dextran Sulfate Sodium-Induced Rat Colitis

K. Takeuchi, S. Kato, H. Nishio, 2005, Digestion.

Comparative effects of the anti-platelet drugs, clopidogrel, ticlopidine, and cilostazol on aspirin-induced gastric bleeding and damage in rats.

K. Takeuchi, S. Takayama, C. Izuhara, 2014, Life sciences.

Polaprezinc Exerts a Salutary Effect on Impaired Healing of Acute Gastric Lesions in Diabetic Rats

K. Takeuchi, Keizo Suzuki, R. Korolkiewicz, 2000, Digestive Diseases and Sciences.

Gastrointestinal Protective Action of Prostaglandin E2 and EP Receptor Subtypes

K. Takeuchi, A. Tanaka, S. Kato, 2002 .

Prophylactic effect of monosodium glutamate on NSAID-induced enteropathy in rats.

K. Takeuchi, K. Amagase, E. Nakamura, 2014, Current pharmaceutical design.

Mechanism of Capsaicin-Stimulated Gastric HCO3- Secretion – Comparison with Mucosal Acidification

K. Takeuchi, E. Aihara, 2014 .

[Effect of the dry distillation tar of delipidated soybean (Glyteer) on a psoriasic model in the mouse (4)].

K. Takeuchi, K. Ito, S. Namikawa, 1992, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

A 2008 Questionnaire-Based Survey of Gastroesophageal Reflux Disease and Related Diseases by Physicians in East Asian Countries

A. Terano, K. Hahm, T. Joh, 2009, Digestion.

Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats.

K. Takeuchi, K. Amagase, Y. Yoshida, 2013, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

New therapeutic strategy for amino acid medicine: prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy.

K. Takeuchi, K. Amagase, E. Nakamura, 2012, Journal of Pharmacological Sciences.

W1345 Effects of Glutamate, the “Umami” Substance, on Development and Healing of NSAID-Induced Small Intestinal Lesions in Rats

K. Takeuchi, K. Amagase, E. Nakamura, 2010 .

Effects of L-glutamine on various gastric lesions in rats and guinea pigs.

K. Takeuchi, S. Okabe, T. Naganuma, 1976, Digestion.

Exogenous insulin-like growth factor (IGF)-1 improves the impaired healing of gastric mucosal lesions in diabetic rats.

K. Takeuchi, S. Kato, R. Korolkiewicz, 2000, Pharmacological Research.

Endogenous sulfhydryls in healing gastric mucosal injury induced by HCl in the rat.

K. Takeuchi, K. Ueshima, S. Okabe, 1993, Digestion.

Prostaglandin EP receptor subtypes involved in regulating HCO(3)(-) secretion from gastroduodenal mucosa.

K. Takeuchi, E. Aihara, S. Hayashi, 2010, Current pharmaceutical design.

Stimulation by sparkling water of gastroduodenal HCO3- secretion in rats.

K. Takeuchi, Y. Ohashi, E. Aihara, 2009, Medical Science Monitor.

K. Takeuchi, E. Aihara, A. Kobata, 2005, Journal of Pharmacology and Experimental Therapeutics.

Effects of nitric oxide synthase inhibitors on duodenal alkaline secretion in anesthetized rats.

K. Takeuchi, S. Okabe, T. Ohuchi, 1993, European journal of pharmacology.

Contractile effects of porcine galanin(1-29)-NH2 on the rat isolated gastric fundus: mediation by potassium ions.

K. Takeuchi, A. Szyk, P. Rekowski, 1997, Pharmacological research.

Effects of Antiulcer Drugs on Gastric Bleeding Induced by Co-Administration of Low Dose Aspirin and Clopidogrel in Rats

K. Takeuchi, S. Takayama, C. Izuhara, 2011 .

A New Model of Gastric Bleeding in Rats Using Co-Administration of Aspirin Plus Clopidogrel Under Stimulation of Acid Secretion: Prophylactic Effects of Antiulcer Drugs

K. Takeuchi, K. Amagase, S. Takayama, 2011 .

Both Selective COX-1 and COX-2 Inhibitors Aggravate Gastric Damage Induced in Rats by 2-Deoxy-D-Glucose

K. Takeuchi, Y. Hayashi, T. Miyazawa, 2004, Digestion.

The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State

Valérie Capra, Neil A. McDonald, Richard R Neubig, 2007, Molecular Pharmacology.

Involvement of PACAP in acid-induced HCO3- response in rat duodenums.

K. Takeuchi, O. Furukawa, S. Kawauchi, 1998, Pharmacological research.

Protective effect of thiaton, an antispasmodic drug, against indomethacin-induced intestinal damage in rats.

K. Takeuchi, T. Kunikata, S. Kato, 2002, Japanese journal of pharmacology.

Stimulation by capsaicin of gastric alkaline secretion in anesthetized rats.

K. Takeuchi, K. Tachibana, K. Ueshima, 1992, Japanese journal of pharmacology.

Abstracts of the sixth international conference on experimental ulcer

J. H. Baron, H. H. Lawson, R. Hunt, 1988, Digestive Diseases and Sciences.

Fasiglifam/TAK-875, a Selective GPR40 Agonist, Improves Hyperglycemia in Rats Unresponsive to Sulfonylureas and Acts Additively with Sulfonylureas

K. Takeuchi, Masami Suzuki, Y. Tsujihata, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity.

H. Matsui, K. Takeuchi, Hidekazu Suzuki, 2012, Biochemical pharmacology.

New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin

K. Takeuchi, K. Amagase, S. Okabe, 2010, Journal of gastroenterology and hepatology.

[Gastrointestinal cytoprotection by prostaglandin E and EP receptor subtypes].

K. Takeuchi, A. Tanaka, S. Kato, 2001, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Stimulation by nizatidine, a histamine H(2)-receptor antagonist, of duodenal HCO(3)(-)secretion in rats:relation to anti-cholinesterase activity.

K. Takeuchi, O. Furukawa, H. Araki, 2000, World Journal of Gastroenterology.

Prostaglandin E‐type receptor subtypes and gastroduodenal bicarbonate secretion in rats

K. Takeuchi, K. Tashima, M. Kubomi, 1998, Journal of Gastroenterology and Hepatology.

Stimulatory effect of PACAP on gastroduodenal bicarbonate secretion in rats

K. Takeuchi, K. Yagi, M. Kitamura, 1997, Journal of Physiology - Paris.

Pathogenesis of digitoxin-induced duodenal ulcers in pregnant rats. Roles of gastric acid and duodenal alkaline secretion.

K. Takeuchi, S. Okabe, O. Furukawa, 1988, Digestive diseases and sciences.

Variations of gastric transmucosal potential difference and lesion formation during hemorrhagic shock in the rat.

K. Takeuchi, T. Ohno, S. Okabe, 1986, Gastroenterology.

Roles of prostaglandin E and EP receptors in mucosal protection and ulcerhealing in the gastrointestinal tract

K. Takeuchi, K. Amagase, 2017 .

[Gastroduodenal bicarbonate secretion: pharmacological modulation and contribution to mucosal protection].

K. Takeuchi, 1996, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Gastroduodenal bicarbonate secretion in mice with prostaglandin e receptor gene disruption

K. Takeuchi, S. Kato, O. Furukawa, 1998 .

Lubiprostone Prevents NSAID-Induced Small Intestinal Damage by Suppression of Inflammatory Mediators' Expression via EP4 Receptors

K. Takeuchi, S. Kato, K. Amagase, 2011 .

E type prostaglandin inhibits indomethacin-induced gastric lesions through EP1 receptors: A study using rats and knockout mice

K. Takeuchi, Keizo Suzuki, H. Araki, 2000 .

E type prostaglandin inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors: A study using rats and knockout mice

K. Takeuchi, T. Kunikata, A. Tanaka, 2000 .

Title Page. Jpet #199182 Introduction

K. Takeuchi, Y. Akiba, 2012 .

Role of prostaglandin E receptor subtypes in gastroduodenal HCO3- secretion.

K. Takeuchi, E. Aihara, Y. Sasaki, 2005, Medicinal chemistry (Shariqah (United Arab Emirates)).

Irsogladine: overview of the mechanisms of mucosal protective and healing- promoting actions in the gastrointestinal tract.

K. Takeuchi, K. Amagase, T. Murakami, 2012, Current pharmaceutical design.

Influences of urethane anesthesia on indomethacin-induced gastric mucosal lesions in rats

K. Takeuchi, S. Okabe, T. Ohuchi, 1994, Digestive Diseases and Sciences.

Role of macrophage colony-stimulating factor (M-CSF)-dependent macrophages in gastric ulcer healing in mice.

K. Takeuchi, Y. Kawahara, S. Kato, 2011, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Importance of cyclooxygenase‐1/prostacyclin in modulating gastric mucosal integrity under stress conditions

K. Takeuchi, K. Amagase, T. Wada, 2014, Journal of gastroenterology and hepatology.

Roles of EP4 Receptors in Protective and Healing-Promoting Effects of Prostaglandin E2 on NSAID-Induced Small Intestinal Damage

K. Takeuchi, 2012 .

Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility.

K. Takeuchi, 2012, World journal of gastroenterology.

Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.

K. Takeuchi, H. Satoh, A. Tanaka, 2010, Clinica chimica acta; international journal of clinical chemistry.

Roles of Endogenous Prostaglandins and Cyclooxygenase Isozymes in Healing of Indomethacin-Induced Small Intestinal Lesions in Rats

K. Takeuchi, A. Tanaka, R. Ohno, 2006, Journal of Pharmacology and Experimental Therapeutics.

Aggravation by Paroxetine, a Selective Serotonin Reuptake Inhibitor, of Antral Lesions Generated by Nonsteroidal Anti-Inflammatory Drugs in Rats

K. Takeuchi, A. Tanaka, K. Amagase, 2011, Journal of Pharmacology and Experimental Therapeutics.

Endogenous prostaglandin E2 accelerates healing of indomethacin‐induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors

K. Takeuchi, K. Amagase, R. Hatazawa, 2010, Journal of gastroenterology and hepatology.

Gastric Cytoprotection by Prostaglandin E2 - Relation to EP Receptor Subtypes -

K. Takeuchi, S. Kato, Y. Ogawa, 2002 .

Impairment by activation of TRPA1 of gastric epithelial restitution in a wound model using RGM1 cell monolayer

K. Takeuchi, E. Nakamura, S. Hayashi, 2007, Inflammopharmacology.

A novel model of ischemic enteritis induced in rats by stenosis of the superior mesenteric artery.

K. Takeuchi, T. Kotani, Yoshino Komatsu, 2009, Life sciences.

Effects of nitric oxide synthase inhibitors on gastric alkaline secretion in rats.

K. Takeuchi, H. Sugawara, S. Okabe, 1992, Japanese journal of pharmacology.

Regulation of gastroduodenal bicarbonate secretion by capsaicin-sensitive sensory neurons in rats.

K. Takeuchi, S. Okabe, T. Ohuchi, 1993, Journal of clinical gastroenterology.

Pentagastrin protects against stress ulceration in rats.

K. Takeuchi, L. Johnson, K. Takeuchi, 1979, Gastroenterology.

Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice.

C. Yabe-Nishimura, K. Takeuchi, S. Kato, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Front & Back Matter

K. Takeuchi, L. Filaretova, 2012, Digestion.

Corrigendum to “Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554” [Bioorg. Med. Chem. 19 (2011) 4482–4498]

J. Yano, K. Aertgeerts, K. Takeuchi, 2011 .

Protective effect of lafutidine, a novel H2-receptor antagonist, on reflux esophagitis in rats through capsaicin-sensitive afferent neurons.

K. Takeuchi, S. Kato, M. Yamato, 2003, Journal of pharmacological sciences.

Mucosal Protective Agents Prevent Exacerbation of NSAID-Induced Small Intestinal Lesions Caused by Antisecretory Drugs in Rats

K. Takeuchi, H. Satoh, K. Amagase, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Effects of Helicobacter pylori infection on gastric parietal cells and E-cadherin in Mongolian gerbils.

K. Takeuchi, R. Takahashi, A. Sugiyama, 2013, Journal of pharmacological sciences.

Influence of adrenalectomy on protective effects of urocortin I, a corticotropin-releasing factor (CRF)-related peptide, against indomethacin-induced enteropathy in rats

K. Takeuchi, 2020 .

Prevention by Parenteral Aspirin of Indomethacin-Induced Gastric Lesions in Rats: Mediation by Salicylic Acid

K. Takeuchi, A. Tanaka, S. Kato, 2002, Digestive Diseases and Sciences.

Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.

J. Yano, K. Aertgeerts, K. Takeuchi, 2011, Journal of medicinal chemistry.