J. Kuemmerle

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Activation of the umami taste receptor (T1R1/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon.

K. Murthy, J. Desimone, V. Lyall, 2014, American journal of physiology. Gastrointestinal and liver physiology.

IGF-I stimulates human intestinal smooth muscle cell growth by regulation of G1 phase cell cycle proteins.

J. Kuemmerle, Huiping Zhou, J. Bowers, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Increased Activation of Latent TGF-&bgr;1 by &agr;V&bgr;3 in Human Crohn's Disease and Fibrosis in TNBS Colitis Can Be Prevented by Cilengitide

K. Murthy, J. Kuemmerle, J. Grider, 2013, Inflammatory bowel diseases.

Synergistic regulation of NOS II expression by IL-1β and TNF-α in cultured rat colonic smooth muscle cells.

J. Kuemmerle, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Insulin-like growth factor-binding protein-5 stimulates growth of human intestinal muscle cells by activation of G{alpha}i3.

K. Murthy, S. Mahavadi, J. Kuemmerle, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Insulin-like growth factors in the gastrointestinal tract and liver.

J. Kuemmerle, 2012, Endocrinology and metabolism clinics of North America.

Occupation of αvβ3-integrin by endogenous ligands modulates IGF-I receptor activation and proliferation of human intestinal smooth muscle

J. Kuemmerle, 2006 .

Motility disorders of the small intestine: new insights into old problems.

J. Kuemmerle, 2000, Journal of clinical gastroenterology.

Noncanonical STAT3 Activation Regulates Excess TGF-β1 and Collagen I Expression in Muscle of Stricturing Crohn’s Disease

K. Murthy, J. Kuemmerle, J. Grider, 2015, The Journal of Immunology.

Effective use of technology in gastroenterology training.

J. Kuemmerle, 2012, Gastroenterology.

Agonist-activated, ryanodine-sensitive, IP3-insensitive Ca2+ release channels in longitudinal muscle of intestine.

G. Makhlouf, K. Murthy, J. Kuemmerle, 1994, The American journal of physiology.

Coupling of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase to Gi2 in Human Intestinal Smooth Muscle

K. Murthy, J. Kuemmerle, K. S. Murthy, 2001, The Journal of Biological Chemistry.

A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells.

J. Kuemmerle, P. Gordon, N. Fox, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Gastrointestinal hormone responses to meals before and after gastric bypass and vertical banded gastroplasty.

D. Martin, J. Kuemmerle, H. Sugerman, 1990, Annals of surgery.

Endogenous IGF-I protects human intestinal smooth muscle cells from apoptosis by regulation of GSK-3 beta activity.

J. Kuemmerle, 2005, American journal of physiology. Gastrointestinal and liver physiology.

IGF-I elicits growth of human intestinal smooth muscle cells by activation of PI3K, PDK-1, and p70S6 kinase.

J. Kuemmerle, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line‐derived neurotrophic factor

J. Grider, R. Heuckeroth, K. Murthy, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells.

G. Makhlouf, K. Murthy, J. Kuemmerle, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Sustained muscle contraction induced by agonists, growth factors, and Ca(2+) mediated by distinct PKC isozymes.

G. Makhlouf, K. Murthy, J. Kuemmerle, 2000, American journal of physiology. Gastrointestinal and liver physiology.

American Journal of Physiology: Gastrointestinal and Liver Physiology American Journal of Physiology: Heart and Circulatory Physi- QlQgY American Journal of Physiology: Regulatory, Integrative and Comparative Physiology American Journal of Physiology: Renal, Fluid and Electrolyte

David M. Pritchard, Michael Camilleri, Gianrico Farrugia, 2003 .

Insulin-like growth factor-binding protein-5 stimulates growth of human intestinal muscle cells by activation of G (cid:1) i3

K. Murthy, S. Mahavadi, J. Kuemmerle, 2009 .

Insulin-like growth factor-binding protein-5 stimulates growth of human intestinal muscle cells by activation of G i 3

K. Murthy, S. Mahavadi, J. Kuemmerle, 2009 .

Endogenous IGF-I regulates IGF binding protein production in human intestinal smooth muscle cells.

J. Kuemmerle, 2000, American journal of physiology. Gastrointestinal and liver physiology.

IGF-I stimulates intestinal muscle cell growth by activating distinct PI 3-kinase and MAP kinase pathways.

J. Kuemmerle, T. L. Bushman, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Serotonin neural receptors mediate motilin-induced motility in isolated, vascularly perfused canine jejunum.

J. Kuemmerle, J. Kellum, 1988, The Journal of surgical research.

human intestinal smooth muscle modulates IGF-I receptor activation and proliferation of -integrin by endogenous ligands

J. Kuemmerle, 2016 .

Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in stricturing Crohn's disease.

K. Murthy, J. Kuemmerle, J. Grider, 2010, Gastroenterology.

IGFBP-3 activates TGF-beta receptors and directly inhibits growth in human intestinal smooth muscle cells.

K. Murthy, J. Kuemmerle, J. Bowers, 2004, American journal of physiology. Gastrointestinal and liver physiology.

IGF-I stimulates intestinal muscle cell growth by activating distinct PI 3-kinase and MAP kinase pathways.

J. Kuemmerle, T. L. Bushman, 1998, The American journal of physiology.

Fibrosis in Crohn’s Disease

J. Kuemmerle, A. Bien, 2012 .

Endogenous IGF-I and alpha v beta3 integrin ligands regulate increased smooth muscle growth in TNBS-induced colitis.

J. Kuemmerle, J. Grider, L. Qiao, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Amelioration of excess collagen I&agr;I, fibrosis, and smooth muscle growth in TNBS‐induced colitis in IGF‐I(+/−) mice

K. Murthy, S. Mahavadi, J. Kuemmerle, 2011, Inflammatory bowel diseases.

Endogenous IGFBP‐3 regulates excess collagen expression in intestinal smooth muscle cells of Crohn's disease strictures

K. Murthy, S. Mahavadi, J. Kuemmerle, 2011, Inflammatory bowel diseases.

Longitudinal smooth muscle of the mammalian intestine

G. Makhlouf, K. Murthy, J. Kuemmerle, 2007, Cell Biochemistry and Biophysics.

Regulation of IGFBP-4 levels in human intestinal muscle by an IGF-I-activated, confluence-dependent protease.

J. Kuemmerle, B. Teng, 2000, American journal of physiology. Gastrointestinal and liver physiology.

IGFBP-3 and IGFBP-5 production by human intestinal muscle: reciprocal regulation by endogenous TGF-β1.

J. Kuemmerle, T. L. Bushman, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids.

K. Murthy, S. Mahavadi, J. Kuemmerle, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation.

A. Ivanov, J. Kuemmerle, Dongdong Wang, 2016, The American journal of pathology.

Longitudinal smooth muscle of the mammalian intestine. A model for Ca2+ signaling by cADPR.

G. Makhlouf, K. Murthy, J. Kuemmerle, 1998, Cell biochemistry and biophysics.

Agonist-stimulated Cyclic ADP Ribose

G. Makhlouf, J. Kuemmerle, 1995, The Journal of Biological Chemistry.

Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn's disease and smooth muscle hypertrophy.

J. Kuemmerle, Chao Li, K. Hazelgrove, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Growth Factors in the Gastrointestinal Tract

J. Kuemmerle, J. Barnard, K. McHugh, 2006 .

Genetic and epigenetic regulation of intestinal fibrosis

J. Kuemmerle, Chao Li, 2016, United European gastroenterology journal.

Murine Trinitrobenzoic Acid-Induced Colitis as a Model of Crohn's Disease.

J. Kuemmerle, 2016, Methods in molecular biology.

Regulation of Gβγi-Dependent PLC-β3 Activity in Smooth Muscle: Inhibitory Phosphorylation of PLC-β3 by PKA and PKG and Stimulatory Phosphorylation of Gαi-GTPase-Activating Protein RGS2 by PKG

K. Murthy, S. Mahavadi, J. Kuemmerle, 2014, Cell Biochemistry and Biophysics.

Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine.

J. Kuemmerle, J. Grider, A. Foxx-Orenstein, 1996, Gastroenterology.

Mechanisms That Mediate the Development of Fibrosis in Patients With Crohn's Disease

J. Kuemmerle, Chao Li, 2014, Inflammatory bowel diseases.

Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease

Judy H. Cho, David T. Okou, Claire L. Simpson, 2021, American journal of human genetics.

Epigenetic Regulation of Intestinal Fibrosis

J. Kuemmerle, Chao Li, 2018 .

Loss of γ-cytoplasmic actin triggers myofibroblast transition of human epithelial cells

A. Ivanov, V. Dugina, J. Kuemmerle, 2014, Molecular biology of the cell.

Insulin-like Growth Factor-binding Protein-5 (IGFBP-5) Stimulates Growth and IGF-I Secretion in Human Intestinal Smooth Muscle by Ras-dependent Activation of p38 MAP Kinase and Erk1/2 Pathways*

J. Kuemmerle, Huiping Zhou, 2002, The Journal of Biological Chemistry.

Serotonin release is mediated by muscarinic receptors on duodenal mucosal cells.

J. Kuemmerle, J. Kellum, H. Kraus, 1987, The Journal of surgical research.

Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells.

J. Grider, G. Makhlouf, K. Murthy, 1995, Gastroenterology.

Beta-adrenoceptors on duodenal mucosal cells mediate venous serotonin release.

J. Kuemmerle, J. Kellum, E. Smith, 1988, The Journal of surgical research.

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.

Judy H. Cho, David T. Okou, Claire L. Simpson, 2017, Gastroenterology.

Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans.

Shannon E. Ellis, Judy H. Cho, J. Rioux, 2015, Gastroenterology.

Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.

K. Murthy, S. Mahavadi, J. Kuemmerle, 2014, American journal of physiology. Cell physiology.

The Pathogenesis and Clinical Management of Stricturing Crohn Disease.

S. Bickston, J. Kuemmerle, J. Bohl, 2021, Inflammatory bowel diseases.

Timing of Last Preoperative Dose of Infliximab Does Not Increase Postoperative Complications in Inflammatory Bowel Disease Patients

L. Kang, J. Kuemmerle, J. Gaidos, 2016, Digestive Diseases and Sciences.

Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat

K. Murthy, J. Kuemmerle, J. Grider, 2012, Journal of Neuroinflammation.

Differential changes in brain‐derived neurotrophic factor and extracellular signal‐regulated kinase in rat primary afferent pathways with colitis

J. Kuemmerle, J. Grider, J. Bowers, 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Fibrosis in Crohn ’ s Disease Inflammatory bowel dIsease : a practIcal approach

J. Kuemmerle, S. Katz, Anas A. Alsaleh, 2013 .

Report of the multisociety task force on GI training

G. Gores, L. Brandt, J. Kuemmerle, 2009, Hepatology.

Report of the Multisociety Task Force on GI Training

G. Gores, L. Brandt, J. Kuemmerle, 2009, American Journal of Gastroenterology.

Report of the Multisociety Task Force on GI training.

G. Gores, L. Brandt, J. Kuemmerle, 2009, Gastrointestinal endoscopy.

Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells.

G. Makhlouf, K. Murthy, J. Kuemmerle, 1998, The American journal of physiology.

Nonmuscle Myosin IIA Regulates Intestinal Epithelial Barrier in vivo and Plays a Protective Role During Experimental Colitis

A. Ivanov, J. Kuemmerle, R. Adelstein, 2016, Scientific Reports.