J. Ley

发表

Discovery of salt taste enhancing arginyl dipeptides in protein digests and fermented fish sauces by means of a sensomics approach.

W. Meyerhof, T. Hofmann, A. Schindler, 2011, Journal of agricultural and food chemistry.

Masking Bitter Taste by Molecules

J. Ley, Jakob P. Ley, 2008 .

Characterization of flavor modulating effects in complex mixtures via high temperature liquid chromatography.

J. Ley, K. Engel, K. Reichelt, 2010, Journal of agricultural and food chemistry.

Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects

C. Galassi, J. Ley, V. Somoza, 2020, Nutrients.

Synthesis and Sensory Studies of Umami‐Active Scaffolds

M. Backes, J. Ley, S. Paetz, 2014, Chemistry & biodiversity.

Sweetness Perception is not Involved in the Regulation of Blood Glucose after Oral Application of Sucrose and Glucose Solutions in Healthy Male Subjects

C. Galassi, J. Ley, J. König, 2020, Molecular nutrition & food research.

Identification of Interleukin-8-Reducing Lead Compounds Based on SAR Studies on Dihydrochalcone-Related Compounds in Human Gingival Fibroblasts (HGF-1 cells) In Vitro

J. Ley, V. Somoza, K. Schueller, 2020, Molecules.

Synthesis of polyhydroxylated aromatic mandelic acid amides and their antioxidative potential

J. Ley, H. Bertram, 2001 .

Sensory effects of transient receptor potential channel agonists on whole mouth saliva extensional rheology.

G. Carpenter, G. Proctor, J. Ley, 2017, Journal of texture studies.

Individual Sweet Taste Perception Influences Salivary Characteristics After Orosensory Stimulation With Sucrose and Noncaloric Sweeteners

J. Ley, B. Hausmann, J. König, 2022, Frontiers in Nutrition.

Cinnamyl Isobutyrate Decreases Plasma Glucose Levels and Total Energy Intake from a Standardized Breakfast: A Randomized, Crossover Intervention

N. Müller, J. Ley, J. Hoi, 2018, Molecular nutrition & food research.

The flavanone homoeriodictyol increases SGLT-1-mediated glucose uptake but decreases serotonin release in differentiated Caco-2 cells

J. Ley, J. Hoi, V. Somoza, 2017, PloS one.

Evaluation of unsaturated alkanoic acid amides as maskers of epigallocatechin gallate astringency.

M. Backes, J. Ley, K. Engel, 2013, Journal of agricultural and food chemistry.

The capsaicin analog nonivamide decreases total energy intake from a standardized breakfast and enhances plasma serotonin levels in moderately overweight men after administered in an oral glucose tolerance test: a randomized, crossover trial.

J. Ley, V. Somoza, B. Rohm, 2014, Molecular nutrition & food research.

Nonivamide, a capsaicin analogue, exhibits anti‐inflammatory properties in peripheral blood mononuclear cells and U‐937 macrophages

J. Ley, H. Hatt, V. Somoza, 2017, Molecular nutrition & food research.

Structure-Dependent Effects of Cinnamaldehyde Derivatives on TRPA1-Induced Serotonin Release in Human Intestinal Cell Models

J. Ley, H. Hatt, J. Hoi, 2020, Journal of agricultural and food chemistry.

New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol.

J. Ley, S. Paetz, G. Krammer, 2006, Journal of agricultural and food chemistry.

Impact of lactisole on the time-intensity profile of selected sweeteners in dependence of the binding site

M. Behrens, J. Ley, G. Krammer, 2022, Food chemistry: X.

Characterization of Bitter Compounds via Modulation of Proton Secretion in Human Gastric Parietal Cells in Culture.

J. Ley, V. Somoza, Joachim Hans, 2017, Journal of agricultural and food chemistry.

Rubemamine and Rubescenamine, Two Naturally Occurring N-Cinnamoyl Phenethylamines with Umami-Taste-Modulating Properties.

W. Meyerhof, M. Backes, J. Ley, 2015, Journal of agricultural and food chemistry.

Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae).

J. Ley, G. Krammer, H. Bertram, 2005, Journal of agricultural and food chemistry.

Phytochemical characterization of South African bush tea (Athrixia phylicoides DC.)

J. Ley, K. Engel, K. Reichelt, 2012 .

Identification of cinnamaldehyde as most effective fatty acid uptake reducing cinnamon-derived compound in differentiated Caco-2 cells compared to its structural analogs cinnamyl alcohol, cinnamic acid and cinnamyl isobutyrate.

J. Ley, K. Hölz, J. Hoi, 2019, Journal of agricultural and food chemistry.

Astringent Gallic Acid in Red Wine Regulates Mechanisms of Gastric Acid Secretion via Activation of Bitter Taste Sensing Receptor TAS2R4.

A. Di Pizio, A. Dunkel, J. Ley, 2021, Journal of agricultural and food chemistry.

Comprehensive Metabolite Profiling of Hydrangea macrophylla ssp. serrata Extracts Using Liquid Chromatography Coupled with Electrospray Ionization Ion Mobility Quadrupole Time-of-Flight Mass Spectrometry.

J. Ley, P. Winterhalter, S. Hillebrand, 2022, Journal of agricultural and food chemistry.

Separation of Dihydro-Isocoumarins and Dihydro-Stilbenoids from Hydrangea macrophylla ssp. serrata by Use of Counter-Current Chromatography

J. Ley, G. Jerz, P. Winterhalter, 2022, Molecules.

Hydroxy- or methoxy-substituted benzaldoximes and benzaldehyde-O-alkyloximes as tyrosinase inhibitors.

J. Ley, J P Ley, H J Bertram, 2001, Bioorganic & medicinal chemistry.

Catecholoximes as powerful antioxidants for highly unsaturated lipids

J. Ley, H. Bertram, 2002 .

Identification of a Sweet Taste Enhancing Vanillin Isomer from Mondia whitei via Sensory-Guided Analysis

J. Ley, K. Reichelt, S. Paetz, 2014 .

Identification of enterodiol as a masker for caffeine bitterness by using a pharmacophore model based on structural analogues of homoeriodictyol.

J. Ley, L. Wessjohann, W. Brandt, 2012, Journal of agricultural and food chemistry.

Sensory active piperine analogues from Macropiper excelsum and their effects on intestinal nutrient uptake in Caco-2 cells.

M. Backes, J. Ley, K. Engel, 2017, Phytochemistry.

Bitter Sensing TAS2R50 Mediates the trans-Resveratrol-Induced Anti-inflammatory Effect on Interleukin 6 Release in HGF-1 Cells in Culture.

A. Di Pizio, M. Behrens, J. Ley, 2021, Journal of agricultural and food chemistry.

Biocatalytic Synthesis of Natural Products by O ‐Methyltransferases

J. Ley, L. Wessjohann, M. Dippe, 2016 .

Identification of an anti-inflammatory potential of Eriodictyon angustifolium compounds in human gingival fibroblasts.

J. Ley, V. Somoza, K. Reichelt, 2016, Food & function.

Dihydroisocoumarin Content and Phenotyping of Hydrangea macrophylla subsp. serrata Cultivars under Different Shading Regimes

J. Ley, T. Kraska, R. Pude, 2021, Agronomy.

The Bitter-Tasting Amino Acids L-Arginine and L-Isoleucine Differentially Regulate Proton Secretion via T2R1 Signalling in Human Parietal Cells in Culture.

M. Niv, J. Ley, K. Hölz, 2019, Journal of agricultural and food chemistry.

Important Tastants and New Developments

J. Ley, K. Engel, K. Reichelt, 2011 .

Enzymatic conversion of flavonoids using bacterial chalcone isomerase and enoate reductase.

T. Scheper, U. Bornscheuer, W. Hinrichs, 2014, Angewandte Chemie.

An enzymatic tandem reaction to produce odor-active fatty aldehydes

B. Spengler, J. Ley, H. Zorn, 2022, Applied Microbiology and Biotechnology.

Biotechnological Production of Odor-active Methyl-Branched Aldehydes by a Novel α-Dioxygenase from Crocosphaera subtropica.

J. Ley, H. Zorn, M. Buchhaupt, 2020, Journal of agricultural and food chemistry.

Biotechnological Production of Methyl-Branched Aldehydes.

M. Backes, J. Ley, H. Zorn, 2016, Journal of agricultural and food chemistry.

Discovery of Novel Bacterial Chalcone Isomerases by a Sequence‐Structure‐Function‐Evolution Strategy for Enzymatic Synthesis of (S)‐Flavanones

U. Bornscheuer, J. Ley, Dong-Hee Yi, 2021, Angewandte Chemie.

VIS-NIR Modeling of Hydrangenol and Phyllodulcin Contents in Tea-Hortensia (Hydrangea macrophylla subsp. serrata)

J. Ley, T. Kraska, R. Pude, 2022, Horticulturae.

Synthesis of N-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) and N-(N,N′-Diacetylchitobiosyl) Amides of L-Histidine

J. Ley, M. Peter, 1994 .

Synthesis of l-Histidine and (-)-Spinacine Chitooligosyl Amides1

J. Ley, M. Peter, 1996 .

Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds.

T. Hofmann, L. Bartoshuk, J. Ley, 2014, Chemical senses.

The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes

J. Ley, V. Somoza, Ann‐Katrin Holik, 2017, Front. Pharmacol..

Nonivamide Enhances miRNA let‐7d Expression and Decreases Adipogenesis PPARγ Expression in 3T3‐L1 Cells

D. Marko, J. Ley, V. Somoza, 2015, Journal of cellular biochemistry.

Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells

G. Sanger, M. Behrens, W. Meyerhof, 2017, Proceedings of the National Academy of Sciences.

Structural analogues of homoeriodictyol as flavor modifiers. Part III: short chain gingerdione derivatives.

J. Ley, S. Paetz, G. Krammer, 2008, Journal of agricultural and food chemistry.

Nonivamide, a capsaicin analog, increases dopamine and serotonin release in SH-SY5Y cells via a TRPV1-independent pathway.

J. Ley, V. Somoza, M. Somoza, 2013, Molecular nutrition & food research.

Reducing the Bitter Taste of Pharmaceuticals Using Cell-Based Identification of Bitter-Masking Compounds

J. Ley, V. Somoza, S. Paetz, 2022, Pharmaceuticals.

Appetite-Inducing Effects of Homoeriodictyol: Two Randomized, Cross-Over Interventions.

J. Ley, Anna‐Sophie Stübler, V. Somoza, 2017, Molecular nutrition & food research.

Structure-dependent effects of sweet and sweet taste affecting compounds on their sensorial properties

J. Ley, G. Krammer, Corinna M Karl, 2020, Food chemistry: X.

The advanced glycation end product Nϵ‐carboxymethyllysine and its precursor glyoxal increase serotonin release from Caco‐2 cells

J. Ley, V. Somoza, M. Somoza, 2018, Journal of cellular biochemistry.

Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells.

J. Ley, V. Somoza, B. Rohm, 2015, Food & function.

A 12‐week intervention with nonivamide, a TRPV1 agonist, prevents a dietary‐induced body fat gain and increases peripheral serotonin in moderately overweight subjects

J. Ley, D. Berry, V. Somoza, 2017, Molecular nutrition & food research.

Human Gingival Fibroblasts as a Novel Cell Model Describing the Association between Bitter Taste Thresholds and Interleukin-6 Release

A. Di Pizio, M. Behrens, A. Dunkel, 2023, Journal of agricultural and food chemistry.

Identification of Bitter-Taste Intensity and Molecular Weight as Amino Acid Determinants for the Stimulating Mechanisms of Gastric Acid Secretion in Human Parietal Cells in Culture.

J. Ley, V. Somoza, G. Krammer, 2018, Journal of agricultural and food chemistry.

Structure-activity relationships of trigeminal effects for artificial and naturally occurring alkamides related to spilanthol

J. Ley, G. Krammer, H. Bertram, 2006 .

Biological Evaluation of Natural and Synthesized Homovanillic Acid Esters as Inhibitors of Intestinal Fatty Acid Uptake in Differentiated Caco-2 Cells

J. Ley, Fabia Hentschel, B. Lieder, 2019, Molecules.

Stereoselective Enzymatic Synthesis of cis‐Pellitorine, a Taste Active Alkamide Naturally Occurring in Tarragon

J. Ley, J. Hilmer, G. Krammer, 2004 .

3,4-Dihydroxymandelic acid amides of alkylamines as antioxidants for lipids

J. Ley, H. Bertram, 2003 .

High‐Impact Sulfur Compounds: Constitutional and Configurational Assignment of Sulfur‐Containing Heterocycles

R. Salzer, C. Krafft, J. Ley, 2008, Chemistry & biodiversity.

Capsaicin and nonivamide similarly modulate outcome measures of mitochondrial energy metabolism in HepG2 and 3T3-L1 cells.

E. Heiss, D. Schachner, J. Ley, 2017, Food & function.

Isolation and synthesis of acmellonate, a new unsaturated long chain 2-ketol ester from Spilanthes acmella

J. Ley, G. Krammer, H. Bertram, 2006, Natural product research.

Synthesis of lipophilic clovamide derivatives and their antioxidative potential against lipid peroxidation.

J. Ley, H. Bertram, 2003, Journal of agricultural and food chemistry.

Substrate specificity of the cell envelope-located proteinase of Lactococcus lactis subsp. lactis NCDO 763.

J. Ley, V. Monnet, S. Gonzàlez, 1992, The International journal of biochemistry.

Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells.

J. Ley, V. Somoza, B. Rohm, 2015, Food & function.

Nonivamide, a capsaicin analog, increases dopamine and serotonin release in SH-SY5Y cells via a TRPV1-independent pathway.

J. Ley, V. Somoza, M. Somoza, 2013, Molecular nutrition & food research.

TRPA1 Agonist Cinnamaldehyde Decreases Adipogenesis in 3T3-L1 Cells More Potently than the Non-agonist Structural Analog Cinnamyl Isobutyrate

J. Ley, V. Somoza, C. Czech, 2020, ACS omega.