H. Witchel

发表

The use of standard electrode potentials to predict the taste of solid metals

Mark Miodownik, Zoe Laughlin, Martin Conreen, 2011 .

Engagement: the inputs and the outputs: conference overview

H. Witchel, 2013 .

Non-Participant Observation Methods for Soundscape Design and Urban Planning

André Fiebig, Christine Howes, Jochen Steffens, 2018 .

What does not happen: quantifying embodied engagement using NIMI and self-adaptors

Nachiappan Chockalingam, Robert Needham, Aoife Healy, 2014 .

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.

J. Hancox, H. Witchel, J. Ridley, 2006, Journal of molecular and cellular cardiology.

Time course and voltage dependence of expressed HERG current compared with native ”rapid” delayed rectifier K current during the cardiac ventricular action potential

Harry J. Witchel, J. Hancox, H. Witchel, 1998, Pflügers Archiv.

Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652.

J. Hancox, H. Witchel, C. Dempsey, 2006, Biochemical and biophysical research communications.

hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656.

J. Hancox, H. Witchel, D. Leishman, 2006, Biochemical and biophysical research communications.

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.

Jules C Hancox, Derek J Leishman, Harry J Witchel, 2010, Journal of pharmacological and toxicological methods.

Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin

Jules C Hancox, Derek J Leishman, Harry J Witchel, 2006, British journal of pharmacology.

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome.

Jules C Hancox, Harry J Witchel, J. Hancox, 2006, Journal of molecular and cellular cardiology.

Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine

J. Hancox, H. Witchel, Jules C Hancox, 2002, British journal of pharmacology.

Acquired QT interval prolongation and HERG: implications for drug discovery and development.

John Sharkey, Harry J Witchel, J. Mcculloch, 2004, European journal of pharmacology.

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

Charlotte K. Colenso, J. Hancox, H. Witchel, 2016, Biochemical pharmacology.

Pharmacology of the short QT syndrome N588K‐hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs

J. Hancox, H. Witchel, H J Witchel, 2008, British journal of pharmacology.

Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656

J. Hancox, H. Witchel, A. James, 2006, FEBS letters.

The Low-Potency, Voltage-Dependent HERG Blocker Propafenone—Molecular Determinants and Drug Trapping

Jules C Hancox, Richard B Sessions, Harry J Witchel, 2004, Molecular Pharmacology.

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

J. Hancox, O. Crociani, A. Arcangeli, 2003, British journal of pharmacology.

Rapid communication Disopyramide is an effective inhibitor of mutant HERG K + channels involved in variant 1 short QT syndrome

J. Hancox, H. Witchel, R. S. Duncan, 2006 .

The short QT syndrome

Jules C Hancox, Harry J Witchel, J. Hancox, 2011, Journal of Interventional Cardiac Electrophysiology.

Lidoflazine is a high affinity blocker of the HERG K(+)channel.

J. Hancox, H. Witchel, J. Ridley, 2004, Journal of molecular and cellular cardiology.

High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656.

Jules C Hancox, Harry J Witchel, James T Milnes, 2004, Biochemical and biophysical research communications.

Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide.

H. Witchel, H J Witchel, A. A. Paul, 2001, Biochemical and biophysical research communications.

Spelling Errors and Shouting Capitalization Lead to Additive Penalties to Trustworthiness of Online Health Information: Randomized Experiment With Laypersons

Carina E. I. Westling, H. Critchley, H. Witchel, 2020, Journal of medical Internet research.

Spelling Errors in Brief Computer-Mediated Texts Implicitly Lead to Linearly Additive Penalties in Trustworthiness

Carina E. I. Westling, H. Critchley, H. Witchel, 2022, Frontiers in Psychology.

Proxemics of screen mediation: engagement with reading on screen manifests as diminished variation due to self-control, rather than diminished mean distance from screen

Carlos P. Santos, Carina E. I. Westling, N. Chockalingam, 2020 .

hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome

J. Hancox, J. Cordeiro, H. Witchel, 2009, Biochemical and biophysical research communications.

CellsColorectal Cancers and Regulate Cell Invasion of Tumor Gene and HERG1 Protein Are Overexpressed in herg1

L. Messerini, E. Wanke, O. Crociani, 2004 .

Effects of the Class III antiarrhythmic agent dofetilide (UK‐68,798) on L‐type calcium current from rabbit ventricular myocytes

J. Hancox, H. Witchel, D. Leishman, 2001, The Journal of pharmacy and pharmacology.

Moderately elevated plasma homocysteine impairs functional endothelial recovery following denudation of mouse carotid arteries.

J. Hancox, H. Witchel, C. Jackson, 2004, Metabolism: clinical and experimental.

INPUTS/OUTPUTS : Interdisciplinary Approaches to Causality in Engagement, Immersion, Presence and Related Concepts in Performance and Human Computer Interaction: The Proceedings : 26 June 2013, Brighton and Sussex Medical School, University of Sussex

Judith Good, Harry J. Witchel, Carina E. I. Westling, 2013 .

Newly identified structurally disparate modulators of osmosensitive taurine efflux inhibit cell cycle progression.

R. Morley, H. Witchel, S. Culliford, 2003, European journal of pharmacology.

Inhibition of ERK and JNK Decreases Both Osmosensitive Taurine Release and Cell Proliferation in Glioma Cells

H. Witchel, R. Kozlowski, A. Davies, 2007, Neurochemical Research.

Actions of the selective serotonin re-uptake inhibitor fluvoxamine on HERG-mediated potassium current in a mammalian cell line

J. Hancox, H. Witchel, J. Milnes, 2002 .

Surface-Associated Glycoproteins in Rat Hepatoma Cells: Evidence

G. Firestone, H. Witchel, O. Haffar, 2022 .

Cognitive ergonomics

Dianne M. Murray, G. Veer, H. Witchel, 2021, Interactions.

Psychotropic Drugs, Cardiac Arrhythmia, and Sudden Death

D. Nutt, J. Hancox, H. Witchel, 2003, Journal of clinical psychopharmacology.

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes.

Jules C Hancox, Harry J Witchel, James T Milnes, 2002, Journal of pharmacological and toxicological methods.

Drug-induced hERG block and long QT syndrome.

Harry J Witchel, H. Witchel, 2011, Cardiovascular therapeutics.

herg1 Gene and HERG1 Protein Are Overexpressed in Colorectal Cancers and Regulate Cell Invasion of Tumor Cells

L. Messerini, E. Wanke, O. Crociani, 2004, Cancer Research.

Inhibitory actions of the selective serotonin re‐uptake inhibitor citalopram on HERG and ventricular L‐type calcium currents

Jules C Hancox, Harry J Witchel, J. Hancox, 2002, FEBS letters.

Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin

J. Hancox, H. Witchel, D. Leishman, 2007, Biochemical pharmacology.

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm‐1 scorpion toxin

J. Hancox, O. Crociani, A. Arcangeli, 2003, FEBS letters.

Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome

Henggui Zhang, Ismail Adeniran, Jules C. Hancox, 2011, PLoS Comput. Biol..

Comparative effects of the short QT N588K mutation at 37 degrees C on hERG K+ channel current during ventricular, Purkinje fibre and atrial action potentials: an action potential clamp study.

J. Hancox, J. Cordeiro, H. Witchel, 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

The hERG potassium channel as a therapeutic target

Harry J Witchel, H. Witchel, 2007, Expert opinion on therapeutic targets.

The N588K-HERG K+ channel mutation in the ‘short QT syndrome’: Mechanism of gain-in-function determined at 37 °C

Jules C. Hancox, Harry J. Witchel, Mark J. McPate, 2005 .

Familial And Acquired Long QT Syndrome And The Cardiac Rapid Delayed Rectifier Potassium Current

J. Hancox, H. Witchel, Jules C Hancox, 2000, Clinical and experimental pharmacology & physiology.

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues.

B. Fermini, J. Hancox, A. Alexandrou, 2014, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

J. Hancox, A. Teschemacher, H. Witchel, 1999, British journal of pharmacology.

Spelling Errors and Shouting Capitalization Lead to Additive Penalties to Trustworthiness of Online Health Information: Randomized Experiment With Laypersons (Preprint)

Carina E. I. Westling, H. Critchley, H. Witchel, 2019 .

Non-Instrumental Movement Inhibition (NIMI) Differentially Suppresses Head and Thigh Movements during Screenic Engagement: Dependence on Interaction

Nachiappan Chockalingam, Harry J. Witchel, James K. Ackah, 2016, Front. Psychol..

A Manifesto for Cognitive Ergonomics: Re-evaluating Technology Usability for the 21st Century

Harry J. Witchel, Carina E. I. Westling, Carina E. I. Westling, 2019, ReCogErg@ECCC.

A time series feature of variability to detect two types of boredom from motion capture of the head and shoulders

Aoife Healy, Nachiappan Chockalingam, Harry J. Witchel, 2014, Proceedings of the 2014 European Conference on Cognitive Ergonomics.

Mean head and shoulder heights when seated: subconscious postural cycles during discrete computerised stimuli

Aoife Healy, Nachiappan Chockalingam, Harry J. Witchel, 2013, ECCE.

Inputs and Outputs: Engagement in digital media from the maker's perspective

Harry J. Witchel, Carina E. I. Westling, H. Witchel, 2019, Excursions Journal.

Depleting Serotonin Enhances Both Cardiovascular and Psychological Stress Reactivity in Recovered Patients With Anxiety Disorders

D. Nutt, S. Argyropoulos, H. Witchel, 2006, Journal of clinical psychopharmacology.

Tryptophan depletion reverses the therapeutic effect of selective serotonin reuptake inhibitors in social anxiety disorder

D. Nutt, C. Bell, S. Argyropoulos, 2004, Biological Psychiatry.

Thigh-Derived Inertial Sensor Metrics to Assess the Sit-to-Stand and Stand-to-Sit Transitions in the Timed Up and Go (TUG) Task for Quantifying Mobility Impairment in Multiple Sclerosis

Aoife Healy, Nachiappan Chockalingam, Jochen Klucken, 2018, Front. Neurol..

Structural determinants for high-affinity block of hERG potassium channels.

Michael C Sanguinetti, Harry Witchel, J. Hancox, 2005, Novartis Foundation symposium.

Using Wearable Inertial Sensors to Compare Different Versions of the Dual Task Paradigm during Walking

Björn Eskofier, Daniel Roggen, Aoife Healy, 2017, ECCE.

Automated Electrophysiology Makes the Pace for Cardiac Ion Channel Safety Screening

Clemens Möller, Harry Witchel, H. Witchel, 2011, Front. Pharmacol..

Design tools for interdisciplinary translation of material experiences

Mark Miodownik, Zoe Laughlin, Martin Conreen, 2016 .

Urban sound planning in Brighton and Hove

Jian Kang, Lisa Lavia, M. Easteal, 2014 .

Sounding Brighton: practical approaches towards better soundscapes

Östen Axelsson, Lisa Lavia, M. Easteal, 2012 .

A Preliminary Soundscape Management Model for Added Sound in Public Spaces to Discourage Anti-social and Support Pro-social Effects on Public Behaviour

Jian Kang, Lisa Lavia, Harry J. Witchel, 2016 .

Short QT syndrome.

J. Hancox, H. Witchel, M. McPate, 2006, Future cardiology.

Experience Design: Video Without Faces Increases Engagement But Not Empathy

Nachiappan Chockalingam, Harry J. Witchel, Carina E. I. Westling, 2016 .

Intentional mind wandering is objectively linked to low effort and tasks with high predictability

Carina E. I. Westling, H. Witchel, Catarina I. Peral-Fuster, 2023, ECCE.

Using wearable inertial sensors to detect different strategies for the sit-to-stand transition in multiple sclerosis

Harry J. Witchel, Carina E. I. Westling, Aiswarya Nagasubramony, 2021, ECCE.

The Perception of Materials through Oral Sensation

Mark Miodownik, Zoe Laughlin, Harry J. Witchel, 2014, PloS one.

Inhibition of HERG K+ Current and Prolongation of the Guinea‐Pig Ventricular Action Potential by 4‐Aminopyridine

J. Hancox, H. Witchel, J. Milnes, 2003, The Journal of physiology.

Automated bobbing and phase analysis to measure walking entrainment to music

Adolfo López, Jean-Marc Odobez, Rémi Emonet, 2014, 2014 IEEE International Conference on Image Processing (ICIP).

The short QT syndrome

M. Link, J. Hancox, Henggui Zhang, 2011, Journal of Interventional Cardiac Electrophysiology.

The N588K-HERG K+ channel mutation in the 'short QT syndrome': mechanism of gain-in-function determined at 37 degrees C.

Jules C Hancox, Harry J Witchel, James T Milnes, 2005, Biochemical and biophysical research communications.

The Self‐Assessment Dilemma: An Open‐Source, Ethical Method using Matlab to Formulate Multiple Choice Quiz Questions for Online Reinforcement

Joseph H. Guppy, Harry J Witchel, Joseph H Guppy, 2018, Advances in physiology education.

Using a soundscape approach to develop an acoustic ecology plan for a city

Östen Axelsson, Lisa Lavia, Harry J. Witchel, 2011 .

Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.

J. Hancox, H. Witchel, J. Ridley, 2003, Biochemical and biophysical research communications.

Using body language indicators for assessing the effects of soundscape quality on individuals

Aoife Healy, Nachiappan Chockalingam, Robert Needham, 2013 .

Inputs and Outputs: Engagement in digital media from the maker's perspective

Carina E. I. Westling, H. Witchel, 2019, Excursions Journal.

Two lingering delays in a go/no-go task: mind wandering and caution/uncertainty slow down thought probe response times

Carina E. I. Westling, H. Witchel, Catarina I. Peral-Fuster, 2023, Behav. Inf. Technol..