D. Hampson

发表

Broad-spectrum amino acid-sensing class C G-protein coupled receptors: molecular mechanisms, physiological significance and options for drug development.

A. Conigrave, D. Hampson, 2010, Pharmacology & therapeutics.

Transduction of the central nervous system after intracerebroventricular injection of adeno-associated viral vectors in neonatal and juvenile mice.

D. Hampson, S. Gholizadeh, S. Tharmalingam, 2013, Human gene therapy methods.

Autism spectrum disorders and neuropathology of the cerebellum

David R. Hampson, G. Blatt, D. Hampson, 2015, Front. Neurosci..

The Calcium-Sensing Receptor and Integrins in Cellular Differentiation and Migration

D. Hampson, S. Tharmalingam, 2016, Front. Physiol..

The Structures of Metabotropic Glutamate Receptors

D. Hampson, E. Rose, Jordan E. Antflick, 2008 .

Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor

J. Roder, N. Slater, D. Hampson, 1996, The Journal of Neuroscience.

Glutamate Transporter Coupling to Na,K-ATPase

S. Angers, D. Hampson, Stephane Angers, 2009, The Journal of Neuroscience.

In Silico Molecular Homology Modeling of Neurotransmitter Receptors

L. Kotra, D. Hampson, Minghua Wang, 2007 .

Reduced Phenotypic Severity Following Adeno-Associated Virus-Mediated Fmr1 Gene Delivery in Fragile X Mice

D. Hampson, S. Gholizadeh, J. Arsenault, 2014, Neuropsychopharmacology.

Subchronic Administration and Combination Metabotropic Glutamate and GABAB Receptor Drug Therapy in Fragile X Syndrome

D. Hampson, S. Tharmalingam, L. K. Pacey, 2011, Journal of Pharmacology and Experimental Therapeutics.

Determination of L-serine-O-phosphate in rat and mouse brain tissue using high-performance liquid chromatography and fluorimetric detection.

J. Roder, V. Labrie, D. Hampson, 2010, Analytical biochemistry.

A microplate receptor assay for the amnesic shellfish poisoning toxin, domoic acid, utilizing a cloned glutamate receptor.

D. Hampson, J. Ramsdell, F. V. Van Dolah, 1997, Analytical biochemistry.

Early developmental alterations in GABAergic protein expression in fragile X knockout mice

D. Hampson, L. K. Pacey, Duke Chen, 2010, Neuropharmacology.

Leptophos Metabolism in the Rat: An In Vivo Study of Oxidative Versus Conjugative Modes of Metabolism

D. Hampson, 1980 .

Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain

J. Forman-Kay, A. Bah, D. Hampson, 2018, Molecular Psychiatry.

Broad-spectrum l-amino acid sensing by class 3 G-protein-coupled receptors

A. Conigrave, D. Hampson, 2006, Trends in Endocrinology & Metabolism.

Immunocytochemistry of neurotransmitter receptors.

R. Wenthold, D. Hampson, R. Altschuler, 1990, Journal of electron microscopy technique.

FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype

H. Hirai, D. Hampson, Ayumu Konno, 2016, Human gene therapy.

Expression of fragile X mental retardation protein in neurons and glia of the developing and adult mouse brain

D. Hampson, S. Gholizadeh, Sebok Kumar Halder (PhD), 2015, Brain Research.

The Neuroactive Peptide N-Acetylaspartylglutamate Is Not an Agonist at the Metabotropic Glutamate Receptor Subtype 3 of Metabotropic Glutamate Receptor

D. Hampson, Edwin C. Johnson, Maninder Chopra, 2009, Journal of Pharmacology and Experimental Therapeutics.

Ligand Binding to the Amino-terminal Domain of the mGluR4 Subtype of Metabotropic Glutamate Receptor*

D. Hampson, G. Han, 1999, The Journal of Biological Chemistry.

The effects of a low protein diet on amino acids and enzymes in the serine synthesis pathway in mice

D. Hampson, G. Baker, Jordan E. Antflick, 2010, Amino Acids.

Cloning and characterization of a Family C orphan G‐protein coupled receptor

D. Hampson, Janice B. B. Lam, R. Tsushima, 2005, Journal of neurochemistry.

Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor

A. Burns, P. Roy, D. Hampson, 2012, Neuropharmacology.

Expression of a truncated secreted form of the mGluR3 subtype of metabotropic glutamate receptor.

J. W. Wells, D. Hampson, J. Koo, 2004, Biochemical and biophysical research communications.

Cloning and Characterization of a Metabotropic Glutamate Receptor, mGluR4b

P. O'Hara, D. Hampson, C. Thomsen, 1997, Neuropharmacology.

Calcium-sensing Receptor Modulates Cell Adhesion and Migration via Integrins*

S. Angers, A. Conigrave, D. Hampson, 2011, The Journal of Biological Chemistry.

The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome.

D. Hampson, L. K. Pacey, Daniel C. Adusei, 2011, Biochemical pharmacology.

CHRONIC ADMINISTRATION OF MONOAMINE OXIDASE INHIBITORS: BASIC AND CLINICAL INVESTIGATIONS

D. Hampson, G. Baker, R. T. Coutts, 1985 .

Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure

D. Hampson, R. Mateo, C. Cummins, 2018, Scientific Reports.

Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain.

J. W. Wells, D. Hampson, J. Walter, 1992, European journal of pharmacology.

Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7

G. Collingridge, N. Burnashev, A. Rozov, 2001, The Journal of Neuroscience.

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity

R M Henkelman, D H Geschwind, D. Geschwind, 2014, Molecular Psychiatry.

Gender-Dependent Effects of Maternal Immune Activation on the Behavior of Mouse Offspring

D. Hampson, I. Xuan, 2014, PloS one.

Metabotropic glutamate receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

S. Nakanishi, R. Duvoisin, R. Shigemoto, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Comparisons of proteins and glycoproteins in neuronal plasma membranes, axolemma, Synaptic Membranes, and oligodendroglial plasma membranes

D. Hampson, S. Poduslo, 1987, Journal of neuroscience research.

Distribution of a putative kainic acid receptor in the frog central nervous system determined with monoclonal and polyclonal antibodies: evidence for synaptic and extrasynaptic localization

R. Wenthold, R. Wenthold, D. Hampson, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Sequence and expression of a frog brain complementary DNA encoding a kainate-binding protein

R. Wenthold, K. Wada, Y. Nakatani, 1989, Nature.

Identification and characterization of the ligand binding subunit of a kainic acid receptor using monoclonal antibodies and peptide mapping.

R. Wenthold, D. Hampson, C. Dechesne, 1989, The Journal of biological chemistry.

Isolation, localization, and cloning of a kainic acid binding protein from frog brain.

R. Wenthold, K. Wada, D. Hampson, 1990, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients.

P. V. van Rijen, G. Jansen, C. V. van Veelen, 2006, Brain : a journal of neurology.

Characterization of two alternatively spliced forms of a metabotropic glutamate receptor in the central nervous system of the rat

J. E. Franck, E. Mulvihill, P. Kristensen, 1994, Neuroscience.

Localization of AMPA receptors in the hippocampus and cerebellum of the rat using an anti-receptor monoclonal antibody

R. Wenthold, J. W. Goh, A. Auyeung, 1992, Neuroscience.

The activation of glutamate receptors by kainic acid and domoic acid.

D. Hampson, J. L. Manalo, Jerrie Lynn Manalo, 1998, Natural toxins.

Properties of a recombinant kainate receptor expressed in baculovirus-infected insect cells.

D. Hampson, F. Taverna, 1994, European journal of pharmacology.

Solubilization of Kainic Acid Binding Sites from Rat Brain

R. Wenthold, D. Hampson, D. Huie, 1987, Journal of neurochemistry.

Determination of d-serine and related neuroactive amino acids in human plasma by high-performance liquid chromatography with fluorimetric detection.

D. Hampson, P. Tibbo, G. Baker, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

3D visualization of the regional differences

R M Henkelman, D H Geschwind, D. Geschwind, 2015, Molecular Psychiatry.

Selective Activation of mGlu4 Metabotropic Glutamate Receptors Is Protective against Excitotoxic Neuronal Death

F. Gasparini, F. Nicoletti, R. Giuffrida, 2000, The Journal of Neuroscience.

Genetic Deletion of Regulator of G-protein Signaling 4 (rgs4) Rescues a Subset of Fragile X Related Phenotypes in the Fmr1 Knockout Mouse Keywords: Autism Fragile X Syndrome Gaba B Regulator of G Protein Signaling 4 G-protein Coupled Receptor

D. Kooy, S. Heximer, D. Hampson, 2022 .

Increased GABAB Receptor-Mediated Signaling Reduces the Susceptibility of Fragile X Knockout Mice to Audiogenic Seizures

David R. Hampson, S. Heximer, D. Hampson, 2009, Molecular Pharmacology.

GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors

D. Hampson, Yosuke Niibori, Robert Duba-Kiss, 2021, Frontiers in Neurology.

Pathways to Drug Development for Autism Spectrum Disorders

D. Hampson, S. Gholizadeh, L. K. Pacey, 2012, Clinical pharmacology and therapeutics.

A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line

P. Suzdak, E. Mulvihill, D. Hampson, 1993, Brain Research.

A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover

E. J. Fletcher, P. Suzdak, J. Macdonald, 1993, Journal of neurochemistry.

Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome

P. Kind, O. Danos, J. Bruder, 2020, Neurobiology of Disease.

Molecular modeling and mutagenesis of the ligand‐binding pocket of the mGlu3 subtype of metabotropic glutamate receptor

Xi-Ping Huang, N. Pattabiraman, D. Hampson, 2003, Journal of neurochemistry.

Ion dependence of ligand binding to metabotropic glutamate receptors.

D. Hampson, Donghui Kuang, 2006, Biochemical and biophysical research communications.

Nature of the oligomers formed by muscarinic m2 acetylcholine receptors in Sf9 cells.

J. W. Wells, H. V. Van Tol, P. Park, 2001, European journal of pharmacology.

Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.

J. Medin, S. Walkley, P. Le Faouder, 2017, The American journal of pathology.

Modulation of Absence Seizures by the GABAA Receptor: A Critical Role for Metabotropic Glutamate Receptor 4 (mGluR4)

O. Snead, D. Hampson, P. Banerjee, 2000, The Journal of Neuroscience.

Interregulation between fragile X mental retardation protein and methyl CpG binding protein 2 in the mouse posterior cerebral cortex

D. Hampson, Lu-Yang Wang, J. Eubanks, 2020, Human molecular genetics.

The Application of Adeno-Associated Viral Vector Gene Therapy to the Treatment of Fragile X Syndrome

D. Hampson, Alexander W. M. Hooper, Yosuke Niibori, 2019, Brain sciences.

Sexually Divergent Mortality and Partial Phenotypic Rescue After Gene Therapy in a Mouse Model of Dravet Syndrome

D. Hampson, B. Minassian, Yosuke Niibori, 2019, Human gene therapy.

Donghui Kuang, N Pattabiraman, Lakshmi P Kotra, 2003, Journal of Biological Chemistry.

The molecular characterization of a putative kainic acid receptor.

R. Wenthold, D. Hampson, C. Dechesne, 1990, Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada.

A kainic acid receptor from frog brain purified using domoic acid affinity chromatography.

R. Wenthold, D. Hampson, 1988, The Journal of biological chemistry.

Inhibition of Microtubule Formation by Metabotropic Glutamate Receptors

D. Hampson, Xi‐Ping Huang, 2000, Journal of neurochemistry.

Motor learning in the VOR: the cerebellar component

D. M. Broussard, D. Hampson, H. Titley, 2011, Experimental Brain Research.

Immunocytochemical localization of the metabotropic glutamate receptor mGluR4a in the piriform cortex of the rat

T. Knöpfel, O. Fernandez-Capetillo, D. Hampson, 2000, The Journal of comparative neurology.

Down-Regulation of mGluR5 by Antisense Deoxynucleotides Alters Pharmacological Responses to Applications of ACPD in the Rat Hippocampus

J. Wojtowicz, D. Hampson, F. Dorri, 1997, Experimental Neurology.

Expression profiling of mRNA obtained from single identified crustacean motor neurons: determination of specificity of hybridization

H. Atwood, R. Cooper, D. Hampson, 1996, Invertebrate Neuroscience.

Differential effects of lectins on recombinant glutamate receptors.

J. Macdonald, D. Hampson, R. Pekhletski, 1995, European journal of pharmacology.

Neurochemical changes in rat brain amines after short- and long-term inhibition of monoamine oxidase by a low dose of tranylcypromine

D. Hampson, G. Baker, R. T. Coutts, 1988, Biological Psychiatry.

Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure

D. Hampson, R. Mateo, C. Cummins, 2018, Scientific Reports.

Anatomical phenotyping in a mouse model of fragile X syndrome with magnetic resonance imaging

R. Mark Henkelman, Jason P. Lerch, Jacob Ellegood, 2010, NeuroImage.

Persistent astrocyte activation in the fragile X mouse cerebellum

Sihui Guan, D. Hampson, C. Thomsen, 2015, Brain and behavior.

Delayed myelination in a mouse model of fragile X syndrome.

R. Henkelman, Sihui Guan, D. Hampson, 2013, Human molecular genetics.

Phosphorylation and modulation of a kainate receptor (GluR6) by cAMP-dependent protein kinase.

L. Wang, J. Macdonald, D. Hampson, 1993, Science.

Synaptotagmin-like expression in the motor nerve terminals of crayfish

H. Atwood, R. Cooper, D. Hampson, 1995, Brain Research.

Expression of functional metabotropic and ionotropic glutamate receptors in baculovirus-infected insect cells

J. Macdonald, P. Pennefather, D. Hampson, 1994, Neuroscience Letters.

Palmitoylation of the GluR6 kainate receptor.

D. Hampson, M. Salter, D. Pickering, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Altered glutamate and GABA release within thalamocortical circuitry in metabotropic glutamate receptor 4 knockout mice

X. Wang, O. Snead, D. Hampson, 2005, Neuroscience.

Metabotropic glutamate receptors in GtoPdb v.2023.1 Metabotropic glutamate receptors in GtoPdb v.2023.1

S. Nakanishi, R. Duvoisin, R. Shigemoto, 2023 .

Metabotropic glutamate receptors in GtoPdb v.2021.3

S. Nakanishi, R. Duvoisin, R. Shigemoto, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Tranylcypromine and an N-Cyanoethyl Analogue: Effects on Brain Levels of the Trace Amines β-Phenylethylamine and Tryptamine

R. Micetich, D. Hampson, G. Baker, 1985 .

A rapid and sensitive gas chromatographic method for quantitation of 2-phenylethylamine in brain tissue and urine.

D. Hampson, G. Baker, R. T. Coutts, 1984, Research communications in chemical pathology and pharmacology.

Activation of Family C G-protein-coupled Receptors by the Tripeptide Glutathione*

D. Hampson, Minghua Wang, Yi Yao, 2006, Journal of Biological Chemistry.

Microsoft Word-19658869-file00

D. Hampson, S. Tharmalingam, L. K. Pacey, 2011 .

l-Serine-O-phosphate in the central nervous system

J. Baizer, D. Hampson, G. Baker, 2009, Brain Research.

Localization of the human mGluR4 gene within an epilepsy susceptibility locus(1).

S W Scherer, S. Scherer, O. Snead, 2001, Brain research. Molecular brain research.

Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity

O. Danos, R. Abdoli, J. Bruder, 2021, Molecular therapy. Methods & clinical development.

Detection and quantitation of a ring-hydroxylated metabolite of the antidepressant drug tranylcypromine

T. Rao, R. Micetich, D. Hampson, 2005, Journal of neural transmission.

A rapid and sensitive electron-capture gas chromatographic method for the analysis of tranylcypromine in brain tissue using acetylation and pentafluorobenzoylation.

D. Hampson, G. Baker, R. T. Coutts, 1984, Journal of biochemical and biophysical methods.

Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors.

D. Hampson, V. Peltekova, G. Han, 2000, Brain research. Molecular brain research.

Molecular Basis for the Differential Agonist Affinities of Group III Metabotropic Glutamate Receptors

T. Stormann, D. Hampson, Erica Rosemond, 2004, Molecular Pharmacology.

Molecular Determinants of High Affinity Binding to Group III Metabotropic Glutamate Receptors*

D. Hampson, H. Thøgersen, Erica Rosemond, 2002, The Journal of Biological Chemistry.

Pharmacological profiles of the metabotropic glutamate receptor ligands [3H]L-AP4 and [3H]CPPG

D. Hampson, Mark Naples, 2001, Neuropharmacology.

Probing the Ligand-binding Domain of the mGluR4 Subtype of Metabotropic Glutamate Receptor*

Xi-Ping Huang, D. Hampson, H. Thøgersen, 1999, The Journal of Biological Chemistry.

Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors

D. Hampson, David M. Maclean, B. Chang, 2006, Proceedings of the National Academy of Sciences.

An evaluation of automated in silico ligand docking of amino acid ligands to Family C G-protein coupled receptors.

D. Hampson, Minghua Wang, David R Hampson, 2006, Bioorganic & medicinal chemistry.

Purification of proteolipid protein and production of specific antiserum

D. Hampson, S. Poduslo, 1986, Journal of Neuroimmunology.

The calcium‐sensing receptor and integrins modulate cerebellar granule cell precursor differentiation and migration

D. Hampson, Chiping Wu, S. Tharmalingam, 2016, Developmental neurobiology.

A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides.

L. Wang, J. Macdonald, D. Hampson, 1994, The Journal of biological chemistry.

Characterization of the oligosaccharide side chains on kainate binding proteins and AMPA receptors

D. Hampson, Margo F. Hullebroeck, 1992, Brain Research.

Modulation of glutamate release from parallel fibers by mGlu4 and pre‐synaptic GABAA receptors

D. Hampson, Jordan E. Antflick, Jordan E. Antflick, 2012, Journal of neurochemistry.

Developmental expression of the group III metabotropic glutamate receptor mGluR4a in the medial nucleus of the trapezoid body of the rat

T. Knöpfel, J. Mateos, D. Hampson, 1999, The Journal of comparative neurology.

Identification and localization of a kainate binding protein in the frog inner ear by electron microscopy immunocytochemistry

R. Wenthold, D. Hampson, G. Goping, 1991, Brain Research.

Contribution of Metabotropic Glutamate Receptor mGluR4 to L‐2‐[3H]Amino‐4‐Phosphonobutyrate Binding in Mouse Brain

D. Hampson, C. Thomsen, 1999, Journal of neurochemistry.

Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor.

D. Hampson, R. Gerlai, J. Roder, 1998, Behavioral neuroscience.

CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice

D. Hampson, S. Gray, S. Rawat, 2023, JCI insight.

In silico prediction and in vivo testing of promoters targeting GABAergic inhibitory neurons

J. Bruder, D. Hampson, Yosuke Niibori, 2023, Molecular therapy. Methods & clinical development.

Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse

D. Kooy, S. Heximer, D. Hampson, 2011, Molecular and Cellular Neuroscience.