S. Shields

发表

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

David J Anderson, David J. Anderson, D. J. Cavanaugh, 2009, Proceedings of the National Academy of Sciences.

Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis.

A. Basbaum, S. Shields, W. Eckert, 2003, The journal of pain : official journal of the American Pain Society.

Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury.

E. Arenas, S. Shields, C. González-Fernández, 2014, Journal of neurotrauma.

Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors

David J. Anderson, D. J. Cavanaugh, A. Basbaum, 2010, PAIN®.

Conditional deletion of HCN2 from primary afferents uncovers the heterogeneity of inflammatory hypersensitivity

S. Shields, 2014, PAIN®.

Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma

K. Stark, S. Warming, D. Hackos, 2020, Scientific Reports.

Intracellular pH in primary somatosensory neurons

S. Shields, 2011, Neuroscience Letters.

Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis

S. Dib-Hajj, S. Waxman, R. Butt, 2015, PloS one.

Cerebellar dysfunction in multiple sclerosis: in the blink of an eye

S. Waxman, S. Shields, 2011, Multiple sclerosis.

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

A. Basbaum, D. Julius, S. Jordt, 2001, Nature.

A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.

M. Volgraf, Jun Chen, S. Shields, 2021, ACS medicinal chemistry letters.

Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons

A. Basbaum, K. Skinner, S. Shields, 2007, Pain.

A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis

S. Dib-Hajj, S. Waxman, S. Shields, 2012, Annals of neurology.

BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats

K. Scearce-Levie, S. Warming, W. Forrest, 2017, Scientific Reports.

Sodium Channel Nav1.7 Is Essential for Lowering Heat Pain Threshold after Burn Injury

S. Dib-Hajj, S. Waxman, C. Sommer, 2012, The Journal of Neuroscience.

Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors

D. Hackos, S. Shields, O. Foreman, 2018, The Journal of Neuroscience.

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.

D. Sutherlin, Jun Chen, D. Hackos, 2019, Journal of medicinal chemistry.

A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel

M. Volgraf, Tianbo Li, A. Rohou, 2020, Neuron.

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.

M. Volgraf, A. Rohou, Jun Chen, 2021, Journal of medicinal chemistry.

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

S. Dib-Hajj, S. Waxman, Rebecca P Seal, 2012, PAIN®.

Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma

K. Stark, S. Warming, D. Hackos, 2020, Scientific Reports.

Olfactory ensheathing glia express aquaporin 1

A. Basbaum, S. Shields, P. Phelps, 2010, The Journal of comparative neurology.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

D. Sutherlin, Jun Chen, D. Hackos, 2021, Journal of medicinal chemistry.

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Simon S. Gao, J. Elstrott, M. Volgraf, 2021, The Journal of experimental medicine.

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

C. Brotherton-Pleiss, M. Volgraf, Jun Chen, 2018, Journal of medicinal chemistry.

Group I Metabotropic Glutamate Antagonist Reduces Acute Neuronal Degeneration and Behavioral Deficits after Traumatic Brain Injury in Rats

S. Shields, R. Berman, J. Muizelaar, 2001, Experimental Neurology.

Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids

J. Kaminker, K. Stark, D. Hackos, 2023, Neuron.

Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids

J. Kaminker, K. Stark, D. Hackos, 2023, Neuron.