R. Chan

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Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva.

Y. Guan, H. Yen, M. Chan, 2011, Influenza and other respiratory viruses.

Entry of Influenza A Virus with a α2,6-Linked Sialic Acid Binding Preference Requires Host Fibronectin

L. Poon, O. Li, M. Chan, 2012, Journal of Virology.

DAS181 Inhibits H5N1 Influenza Virus Infection of Human Lung Tissues

Fang Fang, Anne Dell, Stuart M. Haslam, 2009, Antimicrobial Agents and Chemotherapy.

Evolving complexities of influenza virus and its receptors.

G. Air, J. Peiris, R. Russell, 2008, Trends in microbiology.

Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures

Y. Guan, L. Poon, R. Baric, 2013, Journal of Virology.

Hemagglutinin–neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets

Y. Guan, R. Webster, R. Webby, 2011, Proceedings of the National Academy of Sciences.

Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells.

J. Peiris, L. Poon, M. Chan, 2014, Antiviral research.

Comparable Fitness and Transmissibility between Oseltamivir-Resistant Pandemic 2009 and Seasonal H1N1 Influenza Viruses with the H275Y Neuraminidase Mutation

J. Peiris, H. Yen, M. Chan, 2012, Journal of Virology.

Title Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H 1 N 1 influenza viruses with the H 275 Y neuraminidase mutation

J. Peiris, M. Chan, R. Chan, 2012 .

Title Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H 1 N 1 and H 5 N 1 viruses

J. Peiris, M. Chan, R. Chan, 2012 .

Proinflammatory Cytokine Response and Viral Replication in Mouse Bone Marrow Derived Macrophages Infected with Influenza H1N1 and H5N1 Viruses

J. Peiris, M. Chan, R. Chan, 2012, PloS one.

Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses.

M. Chan, R. Chan, J. Nicholls, 2013, Virus research.

Molecular detection of respiratory pathogens and typing of human rhinovirus of adults hospitalized for exacerbation of asthma and chronic obstructive pulmonary disease

R. Chan, D. Hui, P. Chan, 2019, Respiratory Research.

SARS-CoV-2 detection by nasal strips: a superior tool for surveillance of pediatric populations.

R. Chan, P. Chan, K. Chan, 2020, medRxiv.

Infection of swine ex vivo tissues with avian viruses including H7N9 and correlation with glycomic analysis

Y. Guan, J. Peiris, A. Dell, 2013, Influenza and other respiratory viruses.

Modulation of sterol biosynthesis regulates viral replication and cytokine production in influenza A virus infected human alveolar epithelial cells.

J. Peiris, M. Chan, R. Chan, 2015, Antiviral research.

Genomic and evolutionary comparison between SARS-CoV-2 and other human coronaviruses

Zigui Chen, R. Chan, P. Chan, 2020, Journal of Virological Methods.

Glycomic Characterization of Respiratory Tract Tissues of Ferrets

G. Air, J. Peiris, H. Yen, 2014, The Journal of Biological Chemistry.

Tropism of influenza B viruses in human respiratory tract explants and airway organoids

J. Peiris, M. Chan, R. Chan, 2019, European Respiratory Journal.

Replication of H9 influenza viruses in the human ex vivo respiratory tract, and the influence of neuraminidase on virus release

J. Peiris, D. Pérez, M. Chan, 2017, Scientific Reports.

Tropism and innate host responses of a novel avian influenza A H7N9 virus: an analysis of ex-vivo and in-vitro cultures of the human respiratory tract

Y. Guan, J. Peiris, L. Poon, 2013, The Lancet Respiratory Medicine.

SARS-CoV-2 detection by nasal strips: A superior tool for surveillance of paediatric population

R. Chan, P. Chan, M. Wang, 2020, Journal of Infection.

Pathogenesis of SARS coronavirus infection using human lung epithelial cells: an in vitro model.

M. Chan, R. Chan, J. Peiris, 2011, Hong Kong medical journal = Xianggang yi xue za zhi.

Title Tropism and innate host responses of a novel avian influenza A H 7 N 9 virus : an analysis of ex-vivo and in-vitro cultures of the human respiratory tract

R. Chan, 2014 .

Detection of highly pathogenic influenza and pandemic influenza virus in formalin fixed tissues by immunohistochemical methods.

J. Peiris, L. Poon, H. Yen, 2012, Journal of virological methods.

DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis.

L. Aschenbrenner, M. Chan, R. Chan, 2010, The Journal of antimicrobial chemotherapy.

This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells

Y. Guan, R. Chan, W. C. Yu, 2009 .

Title Influenza H 5 N 1 virus infection of polarized human alveolarepithelial cells and lung microvascular endothelial cells

Y. Guan, M. Chan, R. Chan, 2009 .

Influenza H 5 N 1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells

Y. Guan, M. Chan, R. Chan, 2009 .

Replication and pathogenesis of avian influenza A (H5N1) virus infection in polarised human bronchial and alveolar epithelium.

M. Chan, R. Chan, J. Peiris, 2013, Hong Kong medical journal = Xianggang yi xue za zhi.

Replication of avian and seasonal influenza viruses in human bronchus and lung.

M. Chan, R. Chan, W. C. Yu, 2011, Influenza and other respiratory viruses.

H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades.

Y. Guan, Y. Lau, M. Chan, 2011, The Journal of infectious diseases.

Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study.

M. Chan, R. Chan, Kit M. Yuen, 2011, Influenza and other respiratory viruses.

Host DNA released by NETosis in neutrophils exposed to seasonal H1N1 and highly pathogenic H5N1 influenza viruses

J. Peiris, Y. Lau, M. Chan, 2020, Respiratory Research.

Indirubin-3'-oxime as an antiviral and immunomodulatory agent in treatment of severe human influenza virus infection.

M. Chan, R. Chan, N. Mak, 2018, Hong Kong medical journal = Xianggang yi xue za zhi.

Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling

J. Peiris, D. Baker, E. Fish, 2010, PloS one.

Fatal H7N9 pneumonia complicated by viral infection of a prosthetic cardiac valve - an autopsy study.

K. Yuen, M. Chan, R. Chan, 2014, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Temporal patterns in the evolutionary genetic distance of SARS-CoV-2 during the COVID-19 pandemic

Zigui Chen, R. Chan, P. Chan, 2020, bioRxiv.

The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection.

M. Chan, R. Chan, W. C. Yu, 2011, Influenza and other respiratory viruses.

Genetic mismatch explains sizable variation of COVID-19 vaccine efficacy in clinical trials

Zigui Chen, R. Chan, P. Chan, 2021, medRxiv.

Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study

Yi Guan, Y. Guan, J. Peiris, 2014, The Lancet Respiratory Medicine.

Full Factorial Analysis of Mammalian and Avian Influenza Polymerase Subunits Suggests a Role of an Efficient Polymerase for Virus Adaptation

Yi Guan, Y. Guan, L. Poon, 2009, PloS one.

Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo

Y. Guan, R. Webster, E. Lau, 2016, Proceedings of the National Academy of Sciences.

Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells

Y. Guan, M. Chan, R. Chan, 2009, Respiratory research.

Quantifying the transmission advantage associated with N501Y substitution of SARS-CoV-2 in the United Kingdom: An early data-driven analysis.

Zigui Chen, R. Chan, P. Chan, 2021, Journal of travel medicine.

Unravelling the Role of O-glycans in Influenza A Virus Infection

Thomas Haselhorst, Yun Shi, Mark von Itzstein, 2018, Scientific Reports.

Novel Pandemic Influenza A(H1N1) Viruses Are Potently Inhibited by DAS181, a Sialidase Fusion Protein

Fang Fang, Vasiliy P. Mishin, Larisa V. Gubareva, 2009, PloS one.

Study on the mucosal and serological immune response to the Novel Coronavirus (SARS-CoV-2) vaccine

K. Chan, R. Chan, J. Y. Cheung, 2021, medRxiv.

Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling

Bing Sun, Danlin Jia, J. Peiris, 2010, PloS one.

Quantifying the importance of the key sites on haemagglutinin in determining the selection advantage of influenza virus: using A/H3N2 as an example.

Zigui Chen, R. Chan, P. Chan, 2020, The Journal of infection.

Title Novel pandemic influenza A ( H 1 N 1 ) viruses are potently inhibitedby DAS 181 , a sialidase fusion protein

R. Moss, L. Gubareva, T. Tumpey, 2009 .

Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses

M. Chan, R. Chan, W. C. Yu, 2011, Journal of Virology.

Characterization of key amino acid substitutions and dynamics of the influenza virus H3N2 hemagglutinin.

E. Yeoh, R. Chan, P. Chan, 2021, The Journal of infection.

Adherence to Treatment Guideline Improves Patient Outcomes in a Prospective Cohort of Adults Hospitalized for Community-Acquired Pneumonia

R. Chan, D. Hui, G. Lui, 2020, Open forum infectious diseases.

Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice.

Y. Guan, J. Peiris, S. Akira, 2014, The Journal of general virology.

Evaluation of the human adaptation of influenza A/H7N9 virus in PB2 protein using human and swine respiratory tract explant cultures

M. Chan, R. Chan, J. Nicholls, 2016, Scientific Reports.

Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro

Yi Guan, Y. Guan, M. Peiris, 2010, Respiratory research.

Glycomic Analysis of Human Respiratory Tract Tissues and Correlation with Influenza Virus Infection

G. Air, A. Dell, M. Chan, 2013, PLoS pathogens.

Immunopathology and Infectious Diseases Tropism and Innate Host Responses of the 2009 Pandemic H 1 N 1 Influenza Virus in ex Vivo and in Vitro Cultures of Human Conjunctiva and Respiratory Tract

Y. Guan, J. Peiris, L. Poon, 2010 .

Suppression of influenza virus infection by rhinovirus interference – at the population, individual and cellular levels

R. Chan, P. Chan, Marc K. C. Chong, 2021, medRxiv.

Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3

M. Chan, R. Chan, Kit M. Yuen, 2016, Scientific Reports.

Inhibition of Influenza Virus Replication by Oseltamivir Derivatives

R. Chan, Xiao Yang, Cong Ma, 2022, Pathogens.

The Mucosal and Serological Immune Responses to the Novel Coronavirus (SARS-CoV-2) Vaccines

R. Chan, K. Chan, K. Chan, 2021, Frontiers in Immunology.

Unravelling the Role of O-glycans in Influenza A Virus Infection

R. Chan, J. Nicholls, T. Haselhorst, 2018, Scientific Reports.

Tissue Tropism of Swine Influenza Viruses and Reassortants in Ex Vivo Cultures of the Human Respiratory Tract and Conjunctiva

Y. Guan, J. Peiris, L. Poon, 2011, Journal of Virology.

In silico prediction of influenza vaccine effectiveness by sequence analysis.

W. Wu, S. Wong, E. Yeoh, 2021, Vaccine.

Influenza H5N1 and H1N1 Virus Replication and Innate Immune Responses in Bronchial Epithelial Cells Are Influenced by the State of Differentiation

M. Chan, R. Chan, W. C. Yu, 2010, PloS one.

Title Systems-level comparison of host responses induced by pandemic and seasonal influenza A H 1 N 1 viruses in primary human type Ilike alveolar epithelial cells in vitro

Y. Guan, M. Peiris, J. Gardy, 2010 .

Characterization of the evolutionary dynamics of influenza A H3N2 hemagglutinin

E. Yeoh, R. Chan, P. Chan, 2020, bioRxiv.

Oral and Poster Manuscripts

Y. Guan, H. Yen, M. Chan, 2011, Influenza and other respiratory viruses.

Evaluation of the human adaptation of influenza A/H7N9 virus in PB2 protein using human and swine respiratory tract explant cultures

M. Chan, R. Chan, J. Nicholls, 2016, Scientific Reports.

Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses

M. Chan, R. Chan, J. Nicholls, 2011, Journal of Virology.

Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract.

M. Chan, R. Chan, Kit M. Yuen, 2010, The American journal of pathology.

Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3

M. Chan, R. Chan, Kit M. Yuen, 2016, Scientific Reports.

Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro

Y. Guan, M. Peiris, J. Gardy, 2010, Respiratory research.