T. Koves

发表

The influence of speed, grade and mass during simulated off road bicycling.

J. Benedetto, M. Berry, T. Koves, 2000, Applied ergonomics.

Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes.

D. Muoio, T. Koves, K. Fisher-Wellman, 2018, Cell reports.

Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.

E. Ravussin, O. Ilkayeva, D. Muoio, 2012, Cell metabolism.

Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart: A Multisystems Approach

Rick B. Vega, A. Attie, A. Broman, 2014, Circulation. Heart failure.

Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.

Scott B. Crown, D. Wasserman, D. Muoio, 2019, Cell metabolism.

Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome

O. Ilkayeva, D. Muoio, T. Koves, 2021, iScience.

Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis

David S. Paul, R. Coleman, O. Ilkayeva, 2014, Diabetes.

Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs.

E. Lobenhofer, T. Chu, R. Wolfinger, 2006, Molecular cell.

Obesity and lipid stress inhibit carnitine acetyltransferase activity[S]

O. Ilkayeva, C. Newgard, D. Muoio, 2014, Journal of Lipid Research.

Glucose uptake in muscle cell cultures from endurance-trained men.

D. Muoio, T. Koves, Jason R. Berggren, 2005, Medicine & Science in Sports & Exercise.

Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.

P. Neufer, Jeffrey C. Smith, D. Muoio, 2012, The Biochemical journal.

Metabolic Mechanisms of Muscle Insulin Resistance

C. Newgard, D. Muoio, J. An, 2008 .

Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy

R. Coleman, G. Shulman, S. Watkins, 2011, Molecular and Cellular Biology.

Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men.

B. Kahn, G. Dohm, Young-Bum Kim, 2002, American Journal of Physiology. Endocrinology and Metabolism.

Targeted Metabolomics Connects Thioredoxin-interacting Protein (TXNIP) to Mitochondrial Fuel Selection and Regulation of Specific Oxidoreductase Enzymes in Skeletal Muscle*

P. Neufer, O. Ilkayeva, D. Muoio, 2014, The Journal of Biological Chemistry.

Metabolic profiling of muscle contraction in lean compared with obese rodents.

R. Wolfe, O. Ilkayeva, G. Dohm, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Treatment with the 3-Ketoacyl-CoA Thiolase Inhibitor Trimetazidine Does Not Exacerbate Whole-Body Insulin Resistance in Obese Mice

O. Ilkayeva, D. Muoio, T. Koves, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Liver-specific Loss of Long Chain Acyl-CoA Synthetase-1 Decreases Triacylglycerol Synthesis and β-Oxidation and Alters Phospholipid Fatty Acid Composition*

Shuli Wang, R. Coleman, G. Shulman, 2009, The Journal of Biological Chemistry.

Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure

D. Muoio, T. Koves, D. Kelly, 2020, Circulation research.

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

D. Muoio, T. Koves, Wendy Keung, 2010, Diabetes.

Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice.

O. Ilkayeva, E. Spangenburg, D. Muoio, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.

C. Newgard, D. Muoio, Danhong Lu, 2009, Molecular endocrinology.

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.

S. Gygi, Noah Dephoure, A. Sharpe, 2012, Molecular cell.

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase

O. Ilkayeva, D. Muoio, T. Koves, 2009, Diabetes.

Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals

G. Dohm, D. Muoio, T. Koves, 2010, Diabetes.

Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism.

D. Muoio, R. Cortright, T. Koves, 2005, American journal of physiology. Cell physiology.

A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling

M. Kuchibhatla, O. Ilkayeva, L. Mao, 2019, Journal of the Endocrine Society.

Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle.

G. Dohm, D. Muoio, R. Cortright, 2002, American journal of physiology. Endocrinology and metabolism.

Re-patterning of Skeletal Muscle Energy Metabolism by Fat Storage-inducing Transmembrane Protein 2*

G. Cline, D. Muoio, G. Schwartz, 2011, The Journal of Biological Chemistry.

Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness

W. Kraus, E. Hauser, J. Lord, 2022, Scientific Reports.

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics

D. Olson, J. Thompson, O. Ilkayeva, 2019, Cell reports.

Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness

W. Kraus, E. Hoffman, O. Ilkayeva, 2014, Diabetologia.

Increased Insulin Sensitivity in Mice Lacking Collectrin, a Downstream Target of HNF-1 (cid:1)

C. Newgard, D. Muoio, Danhong Lu, 2009 .

Metabolic Profiling of Muscle Contraction in Lean Compared to Obese Rodents Running Title : Contraction and skeletal muscle lipids

R. Wolfe, O. Ilkayeva, G. Dohm, 2010 .

Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities

G. Truskey, D. Muoio, T. Koves, 2022, iScience.

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

David Millington, G. Shulman, G. Cline, 2004, Nature Medicine.

Energy Metabolic Re-Programming in the Hypertrophied and Early Stage Failing Heart: A Multi-systems Approach Lai et al: Metabolic Remodeling in Heart Failure

Rick B. Vega, A. Attie, A. Broman, 2014 .

Sex differences in substrate metabolism and energy homeostasis.

R. Cortright, T. Koves, 2000, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism

S. Kersten, P. Schrauwen, M. Hesselink, 2022, Molecular metabolism.

Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations

D. Muoio, T. Koves, Rita T. Brookheart, 2021, JCI insight.

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.

C. McCall, K. Wood, Nancie J. MacIver, 2019, Cell metabolism.

Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice

O. Ilkayeva, D. Muoio, R. Gross, 2020, Nature Metabolism.

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

Olga Ilkayeva, O. Ilkayeva, C. Newgard, 2008, Cell metabolism.

Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis.

Olga Ilkayeva, R. Coleman, S. Watkins, 2010, Cell metabolism.

Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes – A Pilot Study

W. Kraus, J. Lord, C. Slentz, 2020, Frontiers in Immunology.

Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control*

O. Ilkayeva, F. Hegardt, D. Muoio, 2009, The Journal of Biological Chemistry.

Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency*

Ping Li, Olga Ilkayeva, O. Ilkayeva, 2005, Journal of Biological Chemistry.

The Failing Heart Relies on Ketone Bodies as a Fuel

Rick B. Vega, E. Lewandowski, C. Hoppel, 2016, Circulation.

Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages*

O. Ilkayeva, J. Rathmell, Nancie J. MacIver, 2017, The Journal of Biological Chemistry.

Metabolic changes in Irgm 1-deficient macrophages 1 Metabolic alterations contribute to enhanced inflammatory cytokine production in Irgm 1-deficient macrophages

O. Ilkayeva, J. Rathmell, Nancie J. MacIver, 2017 .

Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.

Jessica R Gooding, Vera B Schrauwen-Hinderling, Lucas Lindeboom, 2015, Cell metabolism.

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

P. Schrauwen, M. Hesselink, D. Muoio, 2013, Journal of Lipid Research.

Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats

T. Koves, S. Gleeson, S. Dworkin, 1995, Psychopharmacology.

Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease.

D. Muoio, T. Koves, 2007, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Measurement of fatty acid oxidation rates in animal tissues and cell lines.

T. Koves, M. Hirschey, Michelle F. Green, 2014, Methods in enzymology.

Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.

Lauran R. Madden, N. Bursac, D. Muoio, 2019, Biomaterials.

Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.

J. Bunn, J. Bain, D. Muoio, 2014, The American journal of clinical nutrition.

Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance

V. Dolinsky, P. Light, J. Dyck, 2010, Diabetes.

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

N. Andrews, M. A. Moseley, E. Soderblom, 2015, EBioMedicine.

Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

W. Kraus, K. Huffman, D. Muoio, 2017, Arthritis Research & Therapy.

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.

R. Wolfe, O. Ilkayeva, D. Zheng, 2007, American journal of physiology. Cell physiology.

Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.

Scott B. Crown, W. Kraus, O. Ilkayeva, 2020, Cell reports.

Metabolic profiling of PPARα−/− mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation

O. Ilkayeva, M. Muehlbauer, D. Muoio, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

- oxidation capacity in skeletal muscle β-estradiol have increased β Men supplemented with 17

Yusu Gu, N. Dalton, K. Peterson, 2010 .

A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults

C. Champagne, J. Bunn, N. Fukagawa, 2013, Diabetes.

Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass

Scott B. Crown, D. Muoio, Jin-Dong Ding, 2021, Molecular metabolism.

Association between muscle fiber composition and blood pressure levels during exercise in men.

T. Koves, J. Houmard, M. Weidner, 2000, American journal of hypertension.

Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood

J. Bunn, D. Muoio, J. Dumas, 2013, The American journal of clinical nutrition.

Metabolomic analysis reveals decreased skeletal muscle amino acid content and altered fatty acid handling in obese humans

O. Ilkayeva, J. Friedman, D. Muoio, 2015, Obesity.

Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles

W. Kraus, M. Connelly, O. Ilkayeva, 2019, Front. Immunol..

Lipid-induced metabolic dysfunction in skeletal muscle.

D. Muoio, T. Koves, 2007, Novartis Foundation symposium.

Ketogenic Diet Prevents Heart Failure from Defective Mitochondrial Pyruvate Metabolism

O. Ilkayeva, D. Muoio, R. Gross, 2020, bioRxiv.

Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles.

Scott B. Crown, Guo-Fang Zhang, D. Muoio, 2023, Cell metabolism.

Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction.

D. Muoio, T. Koves, J. Houmard, 2016, Biochemical and biophysical research communications.

musclegene transcription in denervated skeletal Regulation of glucose transporters GLUT-4 and

C. Gomez, R. Bassel-Duby, C. Newgard, 2015 .

Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat

Steven I. Dworkin, T. Koves, S. Hemby, 1997, Psychopharmacology.

A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.

P. Neufer, D. Holbert, O. Ilkayeva, 2011, The Journal of clinical endocrinology and metabolism.

Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration

T. Koves, C. Co, J. Smith, 2003, Neuroscience.

Chronic Cocaine Administration Increases CNS Tyrosine Hydroxylase Enzyme Activity and mRNA Levels and Tryptophan Hydroxylase Enzyme Activity Levels

James E. Smith, K. Vrana, T. Koves, 1993, Journal of neurochemistry.

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program

O. Ilkayeva, C. Newgard, M. Czech, 2023, Cell reports.

Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity.

Jeffrey W. Santoso, W. Kraus, G. Truskey, 2017, Tissue engineering. Part C, Methods.

Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans

L. Grevendonk, P. Schrauwen, M. Hesselink, 2022, JCI Insight.

Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running.

P. Devita, T. Koves, J. Houmard, 2001, Journal of applied physiology.

wheel running in the mouse Cardiac and skeletal muscle adaptations to voluntary

Rick B. Vega, B. LaFleur, B. Harrison, 2015 .

Time-dependent recovery from the effects of 6-hydroxydopamine lesions of the rat nucleus accumbens on cocaine self-administration and the levels of dopamine in microdialysates

T. Koves, James E. Smith, C. Co, 2004, Psychopharmacology.

Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation1[S]

D. Matthews, J. Bunn, N. Fukagawa, 2015, Journal of Lipid Research.

Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats.

J. Fluckey, S. Pohnert, G. Dohm, 2004, American journal of physiology. Endocrinology and metabolism.

decrements in leg strength after downhill running Relationship between fat-to-fat-free mass ratio and

P. Devita, T. Koves, J. Houmard, 2013 .

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

O. Ilkayeva, C. Newgard, J. Bain, 2008, Cell metabolism.

Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.

Lauran R. Madden, N. Bursac, D. Muoio, 2019, Biomaterials.

Obesity and lipid stress inhibit carnitine acetyltransferase activity[S]

O. Ilkayeva, C. Newgard, D. Muoio, 2014, Journal of Lipid Research.

Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.

O. Ilkayeva, P. Schrauwen, D. Muoio, 2015, Cell metabolism.

Adipose acyl-CoA synthetase-1 (ACSL1) directs fatty acids towards β -oxidation and is required for cold thermogenesis

R. Coleman, O. Ilkayeva, D. Muoio, 2022 .

Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart: A Multisystems Approach

Rick B. Vega, A. Attie, A. Broman, 2014, Circulation. Heart failure.

RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure

M. Lazar, E. Lewandowski, D. Muoio, 2023, The Journal of clinical investigation.