P. Schumacker

发表

Analysis of oxygen delivery and uptake relationships in the Krogh tissue model.

P. Schumacker, R. Samsel, 1989, Journal of applied physiology.

Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis.

T. Vanden Hoek, N. Chandel, P. Schumacker, 2010, Free radical biology & medicine.

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.

N. Chandel, P. Schumacker, M. Simon, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.

P. Schumacker, M. Simon, R. Guzy, 2005, Cell metabolism.

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

N. Chandel, J. Melendez, P. Schumacker, 2000, The Journal of Biological Chemistry.

Mitochondrial complex III is essential for suppressive function of regulatory T cells

M. Mehta, S. Weinberg, N. Chandel, 2019, Nature.

Role of Oxidants in NF-κB Activation and TNF-α Gene Transcription Induced by Hypoxia and Endotoxin1

David S. McClintock, Paul T. Schumacker, Navdeep S. Chandel, 2000, The Journal of Immunology.

Generation of superoxide in cardiomyocytes during ischemia before reperfusion.

T. Vanden Hoek, L. Becker, P. Schumacker, 1999, American journal of physiology. Heart and circulatory physiology.

Cell death during ischemia: relationship to mitochondrial depolarization and ROS generation.

T. Vanden Hoek, P. Schumacker, H. Iwase, 2003, American journal of physiology. Heart and circulatory physiology.

Respiratory Physiology: Basics and Applications

P. Schumacker, A. Leff, 1993 .

Hypoxia inducible factor‐alpha activation in lymphoma and relationship to the thioredoxin family

L. Gordon, J. Winter, A. Holmgren, 2008, British journal of haematology.

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

Paul T. Schumacker, D. James Surmeier, D. Surmeier, 2010, Nature.

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress

J. Surmeier, D. Gius, P. Schumacker, 2017, Human molecular genetics.

Unraveling the biological roles of reactive oxygen species.

Linda Partridge, Thomas Nyström, Christopher J. Chang, 2011, Cell metabolism.

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival.

M. V. Heiden, M. V. Vander Heiden, C. Thompson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The first global screening of protein substrates bearing protein-bound 3,4-Dihydroxyphenylalanine in Escherichia coli and human mitochondria.

Michael Wilde, M. Wilde, Yingming Zhao, 2010, Journal of proteome research.

TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.

C. Thompson, P. Schumacker, H. Shiels, 2000, The American journal of pathology.

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice.

L. Truong, P. Overbeek, J. Long, 2019, The Journal of clinical investigation.

Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.

S. Kron, Simran S Sabharwal, P. Schumacker, 2008, Nature chemical biology.

Hypoxia, anoxia, and O2 sensing: the search continues.

P. Schumacker, 2002, American journal of physiology. Lung cellular and molecular physiology.

Role of Hypoxia-Inducible Factors in Regulating Right Ventricular Function and Remodeling during Chronic Hypoxia-Induced Pulmonary Hypertension.

P. Schumacker, E. Bartom, G. Budinger, 2020, American journal of respiratory cell and molecular biology.

JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension

J. Sznajder, N. Chandel, P. Schumacker, 2017, The Journal of Biological Chemistry.

Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn

S. Wedgwood, P. Schumacker, S. Lakshminrusimha, 2015, Front. Pharmacol..

Remodeling and Pulmonary Hypertension Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic

P. Schumacker, S. Bonnet, E. Michelakis, 2015 .

Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α.

Sanjiv J. Shah, P. Schumacker, S. Berkelhamer, 2014, American journal of respiratory and critical care medicine.

Hypoxia and Hyperoxia

S. Wedgwood, P. Schumacker, R. Steinhorn, 2012 .

Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing.

P. Schumacker, G. Waypa, 2005, Journal of applied physiology.

How does increased cardiac output increase shunt in pulmonary edema?

G. Hedenstierna, P. Wagner, P. Schumacker, 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion.

T. Vanden Hoek, N. Chandel, P. Schumacker, 2011, Biochimica et biophysica acta.

Hypoxia-induced changes in pulmonary and systemic vascular resistance: Where is the O2 sensor?

P. Schumacker, G. Waypa, 2010, Respiratory Physiology & Neurobiology.

Role of Mitochondrial Oxidant Generation in Endothelial Cell Responses to Hypoxia

B. Gewertz, P. Schumacker, Mir H. Ali, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Model for Hypoxic Pulmonary Vasoconstriction Involving Mitochondrial Oxygen Sensing

N. Chandel, P. Schumacker, G. Waypa, 2001, Circulation research.

Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction.

B. Gewertz, N. Chandel, P. Schumacker, 1999, American journal of physiology. Lung cellular and molecular physiology.

Endothelial permeability and IL-6 production during hypoxia : role of ROS in signal transduction

B. Gewertz, N. Chandel, P. Schumacker, 1999 .

Increased p22(phox)/Nox4 expression is involved in remodeling through hydrogen peroxide signaling in experimental persistent pulmonary hypertension of the newborn.

S. Wedgwood, P. Schumacker, S. Lakshminrusimha, 2013, Antioxidants & redox signaling.

Hyperoxia Increases Phosphodiesterase 5 Expression and Activity in Ovine Fetal Pulmonary Artery Smooth Muscle Cells

P. Schumacker, J. Russell, S. Lakshminrusimha, 2008, Circulation research.

Michael A. Burke, Arineh Khechaduri, Amy K. Rines, 2017, Nature communications.

Signal transduction of flumazenil-induced preconditioning in myocytes.

T. Vanden Hoek, L. Becker, P. Schumacker, 2001, American journal of physiology. Heart and circulatory physiology.

Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.

T. Vanden Hoek, L. Becker, P. Schumacker, 2000, Circulation research.

Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes.

T. Vanden Hoek, L. Becker, P. Schumacker, 1999, American journal of physiology. Heart and circulatory physiology.

Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes.

T. Vanden Hoek, L. Becker, P. Schumacker, 1999, The American journal of physiology.

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes*

T. Vanden Hoek, L. Becker, P. Schumacker, 1998, The Journal of Biological Chemistry.

Ventilation-perfusion imbalance after head trauma.

J. Newell, P. Schumacker, D. Shah, 1979, The American review of respiratory disease.

Molecular Oxygen Modulates Cytochrome c Oxidase Function*

N. Chandel, P. Schumacker, G. Budinger, 1996, The Journal of Biological Chemistry.

Reperfusion injury on cardiac myocytes after simulated ischemia.

T. Vanden Hoek, L. Becker, P. Schumacker, 1996, The American journal of physiology.

Oxygen delivery and uptake by peripheral tissues: physiology and pathophysiology.

P. Schumacker, R. Samsel, R. W. Samsel, 1989, Critical care clinics.

Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes*

N. Chandel, P. Schumacker, J. Duranteau, 1998, The Journal of Biological Chemistry.

The concept of a critical oxygen delivery

S. Cain, P. Schumacker, 1987, Intensive Care Medicine.

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice.

Yuan Cheng, G. Mutlu, V. Bohr, 2015, American journal of respiratory cell and molecular biology.

ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel.

T. Vanden Hoek, P. Schumacker, G. Lebuffe, 2003, American journal of physiology. Heart and circulatory physiology.

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.

M. Gladwin, R. Weinshilboum, M. Humbert, 2010, American journal of respiratory and critical care medicine.

Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion.

T. Vanden Hoek, L. Becker, P. Schumacker, 1997, Journal of molecular and cellular cardiology.

Pathological supply dependence of systemic and intestinal O2 uptake during endotoxemia.

P. Schumacker, R. Samsel, L. Wood, 1988, Journal of applied physiology.

Critical O2 delivery to skeletal muscle at high and low PO2 in endotoxemic dogs.

S. Cain, P. Schumacker, R. Samsel, 1989, Journal of applied physiology.

Systemic and intestinal limits of O2 extraction in the dog.

S. Cain, S. Dodd, P. Schumacker, 1987, Journal of applied physiology.

Cellular oxygen sensing by mitochondria: old questions,

R. Meidan, L. Walker, P. Buttrick, 2015 .

Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling.

J. Marks, Simran S Sabharwal, P. Schumacker, 2013, The Biochemical journal.

Roles of HIF1 and HIF2 in pulmonary hypertension: it all depends on the context

P. Schumacker, G. Waypa, 2019, European Respiratory Journal.

Mitochondria in lung biology and pathology: more than just a powerhouse.

C. Piantadosi, K. Nakahira, A. Choi, 2014, American journal of physiology. Lung cellular and molecular physiology.

Hyperoxia‐induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS

Emelyn H. Shroff, N. Chandel, F. Weinberg, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cellular Responses to Hypoxia: Role of Oxidant Signal Transduction

P. Schumacker, 2002 .

Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction

P. Schumacker, Kimberly A. Smith, 2018, The Journal of physiology.

Calcium Entry and α-Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

D. Surmeier, V. Lee, J. N. Guzman, 2013, The Journal of Neuroscience.

1-10-2008 AMP-Activated Protein Kinase Regulates CO 2-Induced Alveolar Epithelial Dysfunction in Rats and Human Cells by Promoting Na , K-ATPase Endocytosis

J. Sznajder, W. Seeger, N. Chandel, 2019 .

AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.

J. Sznajder, W. Seeger, N. Chandel, 2008, The Journal of clinical investigation.

Intracellular Signaling by Reactive Oxygen Species during Hypoxia

N. Chandel, P. Schumacker, J. Duranteau, 1999 .

Mitochondria-targeted Ogg1 and Aconitase-2 Prevent Oxidant-induced Mitochondrial DNA Damage in Alveolar Epithelial Cells*

S. Weitzman, Yuan Cheng, V. Bohr, 2014, The Journal of Biological Chemistry.

Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes

L. Becker, P. Schumacker, C. Yuan, 2003, Cardiovascular Toxicology.

Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro.

T. Vanden Hoek, L. Becker, P. Schumacker, 2004, The American journal of Chinese medicine.

Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes.

N. Chandel, P. Schumacker, Z. Shao, 2002, American journal of physiology. Lung cellular and molecular physiology.

Is enough oxygen too much?

P. Schumacker, 2010, Critical care.

P. Schumacker, B. Chang, Shawn S Badal, 2016, Journal of the American Society of Nephrology : JASN.

Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells.

P. Overbeek, J. Long, P. Schumacker, 2012, Cell metabolism.

Effects of endotoxin in vivo on endothelial and smooth-muscle function in rabbit and rat aorta.

P. Schumacker, R. Samsel, J. Umans, 1993, The American review of respiratory disease.

Mitochondrial electron transport can become a significant source of oxidative injury in cardiomyocytes.

T. Vanden Hoek, L. Becker, P. Schumacker, 1997, Journal of molecular and cellular cardiology.

Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells.

S. Wedgwood, P. Schumacker, Jacqueline M. Schriewer, 2012, Antioxidants & redox signaling.

PULMONARY, SLEEP, AND CRITICAL CARE UPDATE Update in Pulmonary Vascular Diseases 2013

P. Hassoun, P. Schumacker, 2014 .

MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension. Focus on "miR-223 reverses experimental pulmonary arterial hypertension".

J. Yuan, P. Schumacker, Kimberly A. Smith, 2015, American journal of physiology. Cell physiology.

Focus on "MiR-223 Reverses Experimental Pulmonary Hypertension" 2 3

P. Schumacker, Kimberly A. Smith, 2015 .

Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress.

T. Vanden Hoek, L. Becker, P. Schumacker, 2004, Biochimica et biophysica acta.

Pulmonary gas exchange during high-frequency ventilation.

J. West, P. Wagner, P. Schumacker, 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

Transit time heterogeneity in canine small intestine: significance for oxygen transport.

P. Schumacker, L. A. Maginniss, H. Connolly, 1997, The Journal of clinical investigation.

A tumor suppressor SIRTainty.

P. Schumacker, 2010, Cancer cell.

Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn

S. Wedgwood, P. Schumacker, S. Lakshminrusimha, 2010, Respiratory Physiology & Neurobiology.

Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension.

S. Wedgwood, P. Schumacker, J. Russell, 2011, Antioxidants & redox signaling.

Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells.

S. Wedgwood, P. Schumacker, S. Lakshminrusimha, 2015, American journal of physiology. Lung cellular and molecular physiology.

Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro.

N. Punjabi, P. Schumacker, J. Solway, 1994, Journal of applied physiology.

Cellular Responses to Hypoxia: Possible Relevance to Multiple Organ Failure in Critical Illness?

N. Chandel, P. Schumacker, 2002 .

Pathological supply dependence of O2 uptake during bacteremia in dogs.

P. Schumacker, R. Samsel, L. Wood, 1987, Journal of applied physiology.

Oxygen delivery to tissues.

P. Schumacker, R. Samsel, RW Samsel, 1991, The European respiratory journal.

Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent.

A. Datta, P. Schumacker, S. Berkelhamer, 2015, American journal of physiology. Lung cellular and molecular physiology.

Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons

D. Surmeier, T. Tkatch, M. Iino, 2022, Science advances.

Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes.

T. Vanden Hoek, N. Chandel, P. Schumacker, 2007, Free radical biology & medicine.

Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes.

T. Vanden Hoek, L. Becker, P. Schumacker, 1999, Journal of molecular and cellular cardiology.

Physiological redox signaling in lung, cardiovascular and neural cells: Progress, controversy and potential

P. Schumacker, J. Ward, 2010, Respiratory Physiology & Neurobiology.

Inhibition of cytochrome-c oxidase activity during prolonged hypoxia.

N. Chandel, P. Schumacker, G. Budinger, 1995, The American journal of physiology.

O2 supply dependence of respiration in patients with mitral stenosis undergoing valvuloplasty.

T. Feldman, P. Schumacker, G. Budinger, 1996, American journal of respiratory and critical care medicine.

Oxygen supply dependency in critical illness: an evolving understanding

P. Schumacker, 1998, Intensive Care Medicine.

Oxygen delivery and consumption relationships: Current perspectives

P. Schumacker, 1996 .

Absence of supply dependence of oxygen consumption in patients with septic shock.

C. Manthous, P. Schumacker, R. Samsel, 1993, Journal of critical care.

Nitric oxide quenches the fire in heart mitochondria

P. Schumacker, 2013, Nature Medicine.

Angiotensin II signaling in the brain: compartmentalization of redox signaling?

P. Schumacker, 2002, Circulation research.

Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age‐old question

P. Schumacker, G. Waypa, 2008, Experimental physiology.

Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis.

S. Weitzman, S. Surapureddi, S. Soberanes, 2009, Free radical biology & medicine.

Effects of hyperthermia and hypothermia on oxygen extraction by tissues during hypovolemia.

P. Schumacker, L. Wood, S. Saltz, 1987, Journal of applied physiology.

Oxygen delivery and uptake relationships in patients with aortic stenosis.

T. Feldman, P. Schumacker, J. Soble, 1994, American journal of respiratory and critical care medicine.

Final general discussion

J. López-Barneo, M. Duchen, N. Chandel, 2006 .

Regulation of Gut Oxygen Delivery, Cellular Oxygen Supply and Metabolic Activity

P. Schumacker, 1996 .

Hypoxia increases ROS signaling and cytosolic Ca(2+) in pulmonary artery smooth muscle cells of mouse lungs slices.

J. Marks, P. Schumacker, G. Waypa, 2010, Antioxidants & redox signaling.

Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology.

P. Schumacker, J. Brorson, H. Zhang, 1999, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Generation of superoxide in cardiomyocytes during ischemia before reperfusion

T. Vanden Hoek, L. Becker, P. Schumacker, 1999 .

Mitochondrial Succinate Dehydrogenase in Chronic Obstructive Pulmonary Disease: Is Complex II Too Complex?

P. Schumacker, 2021, American Journal of Respiratory Cell and Molecular Biology.

Hypoxic conformance of metabolism in primary rat hepatocytes: a model of hepatic hibernation.

N. Chandel, P. Schumacker, G. Budinger, 2006, Hepatology.

Determination of the critical O2 delivery from experimental data: sensitivity to error.

P. Schumacker, R. Samsel, 1988, Journal of applied physiology.

Regulation of perfused capillary density in canine intestinal mucosa during endotoxemia.

P. Schumacker, R. Samsel, M. Wylam, 1992, Journal of applied physiology.

Effect of endotoxin on systemic and skeletal muscle O2 extraction.

P. Schumacker, R. Samsel, L. Wood, 1988, Journal of applied physiology.

Adrenergic vasoconstriction augments tissue O2 extraction during reductions in O2 delivery.

P. Schumacker, R. Samsel, L. A. Maginniss, 1994, Journal of applied physiology.

Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro.

P. Schumacker, R. Samsel, A. Leff, 1990, The American review of respiratory disease.

Hepatic oxygen and lactate extraction during stagnant hypoxia.

A. Pietrabissa, J. Emond, P. Schumacker, 1991, Journal of applied physiology.

Limitations of aerobic metabolism in critical illness.

P. Schumacker, L. Wood, 1984, Chest.

Cyclic Stretch Induces Inducible Nitric Oxide Synthase and Soluble Guanylate Cyclase in Pulmonary Artery Smooth Muscle Cells

S. Wedgwood, P. Schumacker, S. Lakshminrusimha, 2013, International journal of molecular sciences.

The ‘mitoflash’ probe cpYFP does not respond to superoxide

M. Fricker, M. Duchen, H. Forman, 2014, Nature.

Cardiovascular physiology teaching: computer simulations vs. animal demonstrations.

S. Shroff, P. Schumacker, R. Samsel, 1994, The American journal of physiology.

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

P. Schumacker, S. Sabharwal, 2014, Nature Reviews Cancer.

Reactive oxygen species in cancer cells: live by the sword, die by the sword.

P. Schumacker, Paul T Schumacker, 2006, Cancer cell.

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

D. Surmeier, E. Ilijić, P. Schumacker, 2018, The Journal of clinical investigation.

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia

P. Schumacker, R. Guzy, Robert D. Guzy, 2006, Experimental physiology.

Mitochondrial Reactive Oxygen Species Trigger Calcium Increases During Hypoxia in Pulmonary Arterial Myocytes

J. Marks, P. Schumacker, G. Waypa, 2002, Circulation research.

Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange.

M. V. Heiden, M. V. Vander Heiden, C. Thompson, 1999, Molecular cell.

Baicalein attenuates oxidant stress in cardiomyocytes.

T. Vanden Hoek, H. Halpern, L. Becker, 2002, American journal of physiology. Heart and circulatory physiology.

Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants.

P. Schumacker, Mir H. Ali, P. Mungai, 2006, American journal of physiology. Lung cellular and molecular physiology.

Interdependence of HIF-1α and TGF-β/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression.

Rajit K. Basu, S. Hubchak, H. Schnaper, 2011, American journal of physiology. Renal physiology.

Disruption of mitochondrial complex I induces progressive parkinsonism

D. Surmeier, J. López-Barneo, T. Tkatch, 2021, Nature.

Redox regulation of p53 during hypoxia

M. V. Heiden, C. Thompson, N. Chandel, 2000, Oncogene.

Reactive oxygen species in cancer: a dance with the devil.

P. Schumacker, 2015, Cancer cell.

Calcium and Parkinson's disease.

D. Surmeier, E. Ilijić, P. Schumacker, 2017, Biochemical and biophysical research communications.

Distinct Mechanisms of Neurodegeneration Induced by Chronic Complex I Inhibition in Dopaminergic and Non-dopaminergic Cells*

Keith Hyland, Robert Krencik, J. Marks, 2004, Journal of Biological Chemistry.

Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity

Toshifumi Takeuchi, P. Schumacker, S. Kozmin, 2014, Journal of the American Chemical Society.

Influence of opsonic fibronectin deficiency on lung fluid balance during bacterial sepsis.

P. Schumacker, G. Niehaus, T. Saba, 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease*

D. Surmeier, P. Schumacker, 2012, The Journal of Biological Chemistry.

Cellular oxygen sensing by mitochondria: old questions, new insight.

N. Chandel, P. Schumacker, 2000, Journal of applied physiology.

BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

B. Spike, P. Schumacker, K. Macleod, 2007, Molecular and Cellular Biology.

mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function

D. Stumpo, P. Blackshear, I. Ben-Sahra, 2018, Proceedings of the National Academy of Sciences.

ROS‐Mediated PARP Activity Undermines Mitochondrial Function After Permeability Transition Pore Opening During Myocardial Ischemia–Reperfusion

J. Bass, P. Schumacker, Jacqueline M. Schriewer, 2013, Journal of the American Heart Association.

Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.

J. Eisenbart, H. Perlman, S. Soberanes, 2011, American journal of respiratory and critical care medicine.

Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis

N. Chandel, P. Schumacker, R. Guzy, 2007, Molecular and Cellular Biology.

Reactive Oxygen Species Are Downstream Products of TRAF-mediated Signal Transduction*

N. Chandel, P. Schumacker, R. Arch, 2001, The Journal of Biological Chemistry.

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

S. Weinberg, E. Ansó, N. Chandel, 2017, Nature Cell Biology.

Hypoxia-inducible factor-1 (HIF-1).

P. Schumacker, Paul T Schumacker, 2005, Critical care medicine.

Cells depleted of mitochondrial DNA (p0) yield insight into physiological mechanisms

N. Chandel, P. Schumacker, 1999, FEBS letters.

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

M. V. Heiden, C. Thompson, N. Chandel, 1997, Cell.

Mitochondrial complex III is required for hypoxia-induced ROS production and gene transcription in yeast.

P. Schumacker, R. Guzy, M. Mack, 2007, Antioxidants & redox signaling.

The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease

D. Surmeier, P. Schumacker, J. Sánchez-Padilla, 2011, Neuroscience.

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy.

J. Julien, N. Chandel, R. Goldman, 2016, Human molecular genetics.

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

J. Licht, H. Perlman, N. Chandel, 2013, Immunity.

Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia

Paul T. Schumacker, Navdeep S. Chandel, J. Eisenbart, 2007, Molecular and Cellular Biology.

Hibernation during Hypoxia in Cardiomyocytes

N. Chandel, P. Schumacker, J. Duranteau, 1998, The Journal of Biological Chemistry.

Cellular Respiration during Hypoxia

N. Chandel, P. Schumacker, G. Budinger, 1997, The Journal of Biological Chemistry.

Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin.

N. Chandel, P. Schumacker, D. S. McClintock, 2000, Journal of immunology.

Redox signaling during hypoxia in mammalian cells

P. Schumacker, G. Waypa, Kimberly A. Smith, 2017, Redox biology.

Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP.

R. Gascoyne, L. Sehn, L. Gordon, 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Targeting Glucose Consumption and Autophagy in Myeloma with the Novel Nucleoside Analogue 8-Aminoadenosine*

S. Singhal, J. Qian, V. Gandhi, 2009, The Journal of Biological Chemistry.

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Steven M. Graves, P. Greengard, D. Surmeier, 2019, Nature Neuroscience.

O2 sensing, mitochondria and ROS signaling: The fog is lifting.

P. Schumacker, G. Waypa, Kimberly A. Smith, 2016, Molecular aspects of medicine.

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

P. Schumacker, M. Prakriya, D. Dokic, 2011, Molecular and Cellular Biology.

Oxygen Delivery and Uptake: Insights from Animal Studies

P. Schumacker, R. Samsel, 1992 .

Tissue oxygen extraction during hypovolemia: role of hemoglobin P50.

P. Schumacker, L. Wood, G. Long, 1987, Journal of applied physiology.

Organ blood flow haemodynamics and metabolism of the albacore tuna Thunnus alalunga (Bonnaterre).

P. Schumacker, R. Laurs, F. White, 1988, Experimental biology.

Systemic hemorrhage augments local O2 extraction in canine intestine.

P. Schumacker, R. Samsel, 1994, Journal of applied physiology.

Peripheral vascular responses in septic shock. Direct or reflex effects?

P. Schumacker, 1991, Chest.

Systemic and gut O2 extraction during endotoxemia. Role of nitric oxide synthesis.

P. Schumacker, R. Samsel, J. Umans, 1995, American journal of respiratory and critical care medicine.

Cellular and Molecular Mechanisms of O2 Sensing

P. Schumacker, 2014 .

Ventilation-perfusion relationships with high cardiac output in lobar atelectasis.

J. Newell, P. Schumacker, S. Powers, 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

Increased cardiac output increases shunt: role of pulmonary edema and perfusion.

P. Schumacker, P. Breen, I. Mayers, 1985, Journal of applied physiology.

Mitochondrial complex III is essential for regulatory T cell suppressive function

M. Mehta, S. Weinberg, N. Chandel, 2018, Nature.

Oxygen Transport and Uptake in Health and Disease

P. Schumacker, R. Samsel, 1991 .

Pressure, flow, and density relationships in airway models during constant-flow ventilation.

A. Nahum, J. Sznajder, P. Schumacker, 1988, Journal of applied physiology.

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

T. Nyström, H. Bayır, K. Davies, 2022, Nature Metabolism.

Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung.

S. Wedgwood, P. Schumacker, S. Berkelhamer, 2013, Free radical biology & medicine.

Role of hypoxia-inducible factor in cell survival during myocardial ischemia–reperfusion

P. Schumacker, G. Loor, 2008, Cell Death and Differentiation.

Mitochondrial Requirement for Endothelial Responses to Cyclic Strain: Implications for Mechanotransduction Mitochondrial Role in Mechanotransduction, Page 2

P. Schumacker, C. Mathieu, Mir H. Ali, 2022 .

What keeps a resting T cell alive?

J. Opferman, M. V. Vander Heiden, C. Thompson, 1999, Cold Spring Harbor symposia on quantitative biology.

Mitochondrial Complex III-generated Oxidants Activate ASK1 and JNK to Induce Alveolar Epithelial Cell Death following Exposure to Particulate Matter Air Pollution*

S. Soberanes, G. Mutlu, N. Chandel, 2009, Journal of Biological Chemistry.

Mitochondrial Function in Sepsis

C. Deutschman, J. Kellum, M. Pinsky, 2016, Shock.

Lung cell hypoxia: role of mitochondrial reactive oxygen species signaling in triggering responses.

P. Schumacker, 2011, Proceedings of the American Thoracic Society.

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.

I. Ben-Sahra, S. Weinberg, N. Chandel, 2019, Cell metabolism.

Update in pulmonary vascular diseases 2013.

P. Hassoun, P. Schumacker, 2014, American journal of respiratory and critical care medicine.

Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis.

S. Hubchak, H. Schnaper, P. Schumacker, 2013, American journal of physiology. Renal physiology.

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation.

P. Schumacker, M. Simon, R. Young, 2005, Cell metabolism.

Endothelial responses to mechanical stress: Where is the mechanosensor?

Paul T. Schumacker, P. Schumacker, Mir H. Ali, 2002, Critical care medicine.

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

D. Surmeier, W. Oertel, E. Ilijić, 2014, Nature Neuroscience.

Chapter 5 – Cell Metabolism and Tissue Hypoxia

P. Schumacker, 2006 .

Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.

J. Marks, P. Schumacker, Jacqueline M. Schriewer, 2013, American journal of respiratory and critical care medicine.

Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors

J. López-Barneo, P. Schumacker, Ana M. Muñoz-Cabello, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Qian-Kun-Nin, a Chinese herbal medicine formulation, attenuates mitochondrial oxidant stress in cardiomyocytes.

L. Becker, P. Schumacker, C. Yuan, 2001, Journal of ethnopharmacology.

Expression of Hypoxia-Inducible Factor (HIF) Is An Independent Favorable Prognostic Factor in Diffuse Large B-Cell Lymphoma (DLBCL) Treated with R-CHOP

R. Gascoyne, L. Sehn, L. Gordon, 2008 .

Life on the edge: Determinants of selective neuronal vulnerability in Parkinson's disease

J. Surmeier, P. Schumacker, E. Zampese, 2016 .

Determinants of Selective Vulnerability of Dopamine Neurons in Parkinson's Disease

D. Surmeier, P. Schumacker, E. Zampese, 2016 .

Physiological phenotype and vulnerability in Parkinson's disease.

D. Surmeier, P. Schumacker, Javier Sánchez, 2012, Cold Spring Harbor perspectives in medicine.

The role of nitric oxide synthases in the pathophysiology of chronic obstructive pulmonary disease

N. Weissmann, P. Schumacker, N. Parajuli, 2009 .

Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes.

L. Becker, P. Schumacker, C. Yuan, 2003, Pharmacological research.

Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

Michael A. Burke, Arineh Khechaduri, Amy K. Rines, 2017, Nature Communications.

Oxygen conformance of cellular respiration in hepatocytes.

A. Agustí, N. Chandel, P. Schumacker, 1993, The American journal of physiology.

Oxygen supply and consumption in the adult respiratory distress syndrome.

P. Schumacker, R. Samsel, 1990, Clinics in chest medicine.

Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes.

L. Becker, N. Chandel, P. Schumacker, 1996, The American journal of physiology.

Increases in Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Induced Calcium Responses in Pulmonary Artery Smooth Muscle Cells

J. Marks, P. Schumacker, R. Guzy, 2006, Circulation research.

O2 sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens

P. Schumacker, G. Waypa, 2002, Respiratory Physiology & Neurobiology.

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

Paul T. Schumacker, Jeremy D. Marks, J. Marks, 2010, Circulation research.

Current paradigms in cellular oxygen sensing.

P. Schumacker, 2003, Advances in experimental medicine and biology.

H2O2 transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo

P. Schumacker, Charlène Landwerlin, S. Sabharwal, 2023, The Journal of biological chemistry.

Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension.

J. Marks, P. Schumacker, J. Kondapalli, 2013, American journal of respiratory cell and molecular biology.

Oxidant Stress during Simulated Ischemia Primes Cardiomyocytes for Cell Death during Reperfusion*

J. Marks, P. Schumacker, G. Loor, 2007, Journal of Biological Chemistry.

Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing*

H. Kwon, J. Shim, Jiyong Lee, 2010, The Journal of Biological Chemistry.

Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy.

P. Overbeek, J. Long, P. Schumacker, 2017, Kidney international.

BAX OR BAK Mediate Mitochondrial Superoxide Dependent Acute Lung Injury

J. Eisenbart, S. Soberanes, G. Mutlu, 2010, ATS 2010.

Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells.

P. Schumacker, G. Waypa, P. Mungai, 2010, Antioxidants & redox signaling.

Paradoxical Regulation of Hypoxia Inducible Factor-1α (HIF-1α) by Histone Deacetylase Inhibitor in Diffuse Large B-Cell Lymphoma

L. Gordon, A. Evens, P. Schumacker, 2013, PloS one.

The Phillip Morris Foundation for a Smoke‐Free World. A Cause for Concern

J. Wedzicha, E. Mackenzie, J. Samet, 2018, Annals of the American Thoracic Society.

Systemic oxygen delivery and consumption during acute lung injury in dogs

P. Schumacker, L. Wood, G. Long, 1988 .

Role of hemoglobin P50 in O2 transport during normoxic and hypoxic exercise in the dog.

J B West, A J Suggett, J. West, 1985, Journal of applied physiology.

SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF.

P. Schumacker, 2011, Cancer cell.

Rescuing Decrepit Soluble Guanylate Cyclase: A Therapy for Sickle Cell Disease?

P. Schumacker, 2018, American journal of respiratory cell and molecular biology.

Physiological hypoxia promotes survival of cultured cortical neurons

J. Marks, P. Schumacker, Dongdong Li, 2005, The European journal of neuroscience.

The effect of adrenergic agonists on the systemic response to hemorrhage.

P. Schumacker, R. Samsel, L. Wood, 1994, Journal of critical care.

Nitric Oxide Acutely Inhibits Neuronal Energy Production

P. Schumacker, J. Brorson, He Zhang, 1999, The Journal of Neuroscience.

Cytotoxicity induced by grape seed proanthocyanidins: Role of nitric oxide

L. Becker, C. Hsu, P. Schumacker, 2006, Cell Biology and Toxicology.

Alveolar pressure inhomogeneity and gas exchange during constant-flow ventilation in dogs.

A. Nahum, J. Sznajder, P. Schumacker, 1989, Journal of applied physiology.

Selected Bibliography of Recent Research in Sleep Medicine (2020-2021).

N. Ayas, R. Mehra, P. Schumacker, 2023, American journal of respiratory and critical care medicine.

Effects of transfusion-induced polycythemia on O2 transport during exercise in the dog.

J. West, P. Wagner, P. Schumacker, 1985, Journal of applied physiology.

Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP.

R. Gascoyne, L. Sehn, L. Gordon, 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Influence of Gelatin on Bioassayable and Immunoreactive Opsonic Fibronectin 1

P. Schumacker, G. Niehaus, T. Saba, 1981, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Generation of superoxide in cardiomyocytes during ischemia before reperfusion.

L. Becker, P. Schumacker, Z. Shao, 1999, American journal of physiology. Heart and circulatory physiology.

Mitochondrial Function in Sepsis

C. Deutschman, J. Kellum, M. Pinsky, 2016, Shock.

Mitochondrial Complex III-generated Oxidants Activate ASK1 and JNK to Induce Alveolar Epithelial Cell Death following Exposure to Particulate Matter Air Pollution*

S. Soberanes, G. Mutlu, N. Chandel, 2009, Journal of Biological Chemistry.

Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction.

P. Schumacker, Mir H. Ali, Carol E Mathieu, 2004, American journal of physiology. Lung cellular and molecular physiology.

Straining to understand mechanotransduction in the lung.

P. Schumacker, 2002, American Journal of Physiology - Lung cellular and Molecular Physiology.

SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF.

P. Schumacker, 2011, Cancer cell.