J. Ramsdell

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Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines.

M. Satake, T. Mcmahon, T. Yasumoto, 2005, Toxicon : official journal of the International Society on Toxinology.

Development of rapid and sensitive high throughput pharmacologic assays for marine phycotoxins.

E. Finley, J. Ramsdell, G. Doucette, 1994, Natural toxins.

Use of two detection methods to discriminate ciguatoxins from brevetoxins: application to great barracuda from Florida Keys.

M. Dechraoui, J. Ramsdell, H. Granade, 2005, Toxicon : official journal of the International Society on Toxinology.

Biomonitoring of ciguatoxin exposure in mice using blood collection cards.

M. Chinain, J. Ramsdell, P. Cruchet, 2005, Toxicon : official journal of the International Society on Toxinology.

Optimization of ciguatoxin extraction method from blood for Pacific ciguatoxin (P-CTX-1).

J. Ramsdell, Zhihong Wang, M. Bottein Dechraoui, 2007, Toxicon : official journal of the International Society on Toxinology.

Linking ciguatera poisoning to spatial ecology of fish: a novel approach to examining the distribution of biotoxin levels in the great barracuda by combining non-lethal blood sampling and biotelemetry.

S. Cooke, J. Ramsdell, A. Danylchuk, 2012, The Science of the total environment.

Microfluorimetric analysis of a purinergic receptor (P2X7) in GH4C1 rat pituitary cells: effects of a bioactive substance produced by Pfiesteria piscicida.

J. Burkholder, H. Glasgow, J. Ramsdell, 2001, Environmental health perspectives.

Identification of a P2X7 receptor in GH(4)C(1) rat pituitary cells: a potential target for a bioactive substance produced by Pfiesteria piscicida.

J. Burkholder, H. Glasgow, J. Ramsdell, 2001, Environmental health perspectives.

Identification of a P2X7 receptor in GH(4)C(1) rat pituitary cells: a potential target for a bioactive substance produced by Pfiesteria piscicida.

J. Burkholder, H. Glasgow, J. Ramsdell, 2001, Environmental Health Perspectives.

Extraction of domoic acid from seawater and urine using a resin based on 2-(trifluoromethyl)acrylic acid.

I. Chianella, S. Piletsky, J. Ramsdell, 2008, Analytica chimica acta.

Analysis of diarrhetic shellfish poisoning toxins and pectenotoxin-2 in the bottlenose dolphin (Tursiops truncatus) by liquid chromatography-tandem mass spectrometry.

J. Ramsdell, Zhihong Wang, Margaret H. Broadwater, 2015, Journal of chromatography. A.

Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration.

M. Bottein, J. Ramsdell, Zhihong Wang, 2011, Toxicology.

Type B brevetoxins show tissue selectivity for voltage-gated sodium channels: comparison of brain, skeletal muscle and cardiac sodium channels.

J. Ramsdell, M. Bottein Dechraoui, 2003, Toxicon : official journal of the International Society on Toxinology.

Reporter gene assay for fish-killing activity produced by Pfiesteria piscicida.

J. Burkholder, H. Glasgow, J. Ramsdell, 1999, Environmental health perspectives.

Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.

J. Ramsdell, J. Ramsdell, G. Pettit, 1991, The Journal of biological chemistry.

Maitotoxin, a calcium channel activator, inhibits cell cycle progression through the G1/S and G2/M transitions and prevents CDC2 kinase activation in GH4C1 cells

J. Ramsdell, F. V. Van Dolah, 1996, Journal of cellular physiology.

Okadaic acid inhibits a protein phosphatase activity involved in formation of the mitotic spindle of GH4 rat pituitary cells

J. Ramsdell, F. V. Van Dolah, J. Ramsdell, 1992, Journal of cellular physiology.

Domoic Acid Transfer to Milk: Evaluation of a Potential Route of Neonatal Exposure

J. Ramsdell, J. Maucher, 2005, Environmental health perspectives.

The Molecular and Integrative Basis to Domoic Acid Toxicity

J. Ramsdell, 2007 .

A microplate receptor assay for the amnesic shellfish poisoning toxin, domoic acid, utilizing a cloned glutamate receptor.

D. Hampson, J. Ramsdell, F. V. Van Dolah, 1997, Analytical biochemistry.

Review and assessment of in vitro detection methods for algal toxins.

J. Ramsdell, F. V. Van Dolah, 2001, Journal of AOAC International.

Domoic acid is a potent neurotoxin to neonatal rats.

J. Ramsdell, D. Xi, Y. Peng, 1997, Natural toxins.

Brevetoxin Forms Covalent DNA Adducts in Rat Lung Following Intratracheal Exposure

J. Ramsdell, F. Radwan, 2008, Environmental health perspectives.

Intrinsic potency of synthetically prepared brevetoxin cysteine metabolites BTX-B2 and desoxyBTX-B2.

M. Dechraoui, J. Ramsdell, Zhihong Wang, 2007, Toxicon : official journal of the International Society on Toxinology.

Species selective resistance of cardiac muscle voltage gated sodium channels: characterization of brevetoxin and ciguatoxin binding sites in rats and fish.

M. Dechraoui, J. Ramsdell, J. Wacksman, 2006, Toxicon : official journal of the International Society on Toxinology.

Characterization of in vitro oxidative and conjugative metabolic pathways for brevetoxin (PbTx-2).

J. Ramsdell, F. Radwan, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Identification of a rapid detoxification mechanism for brevetoxin in rats.

J. Ramsdell, Zhihong Wang, F. Radwan, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Uptake and Elimination of Brevetoxin in Blood of Striped Mullet (Mugil cephalus) after Aqueous Exposure to Karenia brevis

J. Ramsdell, Kirsten S. Brendtro, Ricky T. Woofter, 2004, Environmental health perspectives.

Measurement of brevetoxin levels by radioimmunoassay of blood collection cards after acute, long-term, and low-dose exposure in mice.

M. Dechraoui, J. Ramsdell, N. R. Towers, 2003, Environmental health perspectives.

Biomonitoring brevetoxin exposure in mammals using blood collection cards.

M. Busman, J. Ramsdell, P. Moeller, 2001, Environmental health perspectives.

The type B brevetoxin (PbTx-3) adversely affects development, cardiovascular function, and survival in Medaka (Oryzias latipes) embryos.

J. Ramsdell, J. R. Colman, 2003, Environmental health perspectives.

Characterization of the developmental toxicity of Caribbean ciguatoxins in finfish embryos.

M. Dechraoui, J. Ramsdell, R. Dickey, 2004, Toxicon : official journal of the International Society on Toxinology.

Thyrotropin-releasing hormone inhibits GH4 pituitary cell proliferation by blocking entry into S phase.

J. Ramsdell, 1990, Endocrinology.

Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of domoic acid in seawater, phytoplankton, and mammalian fluids and tissues.

J. Ramsdell, G. Doucette, C. Mikulski, 2012, Analytica Chimica Acta.

Determination of domoic acid in seawater and phytoplankton by liquid chromatography-tandem mass spectrometry.

J. Ramsdell, G. Doucette, Zhihong Wang, 2007, Journal of chromatography. A.

Embryonic Exposure to Domoic Acid Increases the Susceptibility of Zebrafish Larvae to the Chemical Convulsant Pentylenetetrazole

J. Ramsdell, J. Tiedeken, 2007, Environmental health perspectives.

Developmental toxicity of domoic acid in zebrafish (Danio rerio).

J. Ramsdell, J. Tiedeken, A. Ramsdell, 2005, Neurotoxicology and teratology.

Demonstration of toxicity to fish and to mammalian cells by Pfiesteria species: comparison of assay methods and strains.

J. Burkholder, N. Deamer, H. Marshall, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the dopaminergic regulation of human prolactin-secreting cells cultured on extracellular matrix.

J. Ramsdell, C. Wilson, R. Jaffe, 1982, The Journal of clinical endocrinology and metabolism.

Current progress in isolation and characterization of toxins isolated from Pfiesteria piscicida.

J. Burkholder, H. Glasgow, S. Morton, 2001, Environmental health perspectives.

Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos.

M. Satake, T. Mcmahon, T. Yasumoto, 2005, Toxicon : official journal of the International Society on Toxinology.

Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.

J. Ramsdell, A. Tashjian, G. Pettit, 1986, The Journal of biological chemistry.

Effect of Maitotoxin on Guanine Nucleotide Interaction With G-Protein α Subunits

J. Ramsdell, S. Pentyala, M. Rebecchi, 2001 .

Role of domoic acid and DDT in an emerging epilepsy disorder of California sea lions

J. Ramsdell, 2009 .

Induction of distinct phenotypes in clonal and variant GH4 pituitary cells

J. Ramsdell, 1990, In Vitro Cellular & Developmental Biology.

Preparation and Use of Morphological Variants to Investigate Neuropeptide Action

J. Ramsdell, 1990 .

GH4 pituitary cell variants selected as nonresponsive to thyrotropin‐releasing hormone‐enhanced substratum adhesion are nonresponsive to epidermal growth factor: Evidence for a common signaling defect

J. Ramsdell, A. Tashjian, J. Ramsdell, 1989, Journal of cellular physiology.

Thyrotropin-releasing hormone (TRH) elevation of inositol trisphosphate and cytosolic free calcium is dependent on receptor number. Evidence for multiple rapid interactions between TRH and its receptor.

J. Ramsdell, A. Tashjian, 1986, The Journal of biological chemistry.

Thyrotropin-releasing hormone and epidermal growth factor stimulate prolactin synthesis by a pathway(s) that differs from that used by phorbol esters: dissociation of actions by calcium dependency and additivity.

J. Ramsdell, A. Tashjian, 1985, Endocrinology.

Culture of dispersed anterior pituitary cells on extracellular matrix.

J. Ramsdell, C. Bethea, R. Weiner, 1983, Methods in enzymology.

Transforming Growth Factor-a and -0 Are Potent and Effective Inhibitors of GH4 Pituitary Tumor Cell Proliferation*

J. Ramsdell, 1991 .

Pilocarpine-Induced Seizures Revisited: What Does the Model Mimic?

C. Stafstrom, A. Vezzani, J. Ramsdell, 2009, Epilepsy currents.

Neurological Disease Rises from Ocean to Bring Model for Human Epilepsy to Life

J. Ramsdell, 2010, Toxins.

In Utero Domoic Acid Toxicity: A Fetal Basis to Adult Disease in the California Sea Lion (Zalophus californianus)

J. Ramsdell, T. Zabka, 2008, Marine drugs.

Domoic acid induced status epilepticus promotes aggressive behavior in rats

J. Ramsdell, P. Pennington, J. Fuquay, 2012, Physiology & Behavior.

Detection of marine toxins, brevetoxin-3 and saxitoxin, in seawater using neuronal networks.

N. Kulagina, J. Pancrazio, Wu Ma, 2006, Environmental science & technology.

BREVETOXIN IN BLOOD, BIOLOGICAL FLUIDS, AND TISSUES OF SEA TURTLES NATURALLY EXPOSED TO KARENIA BREVIS BLOOMS IN CENTRAL WEST FLORIDA

Victoria L. Socha, J. Ramsdell, C. Manire, 2013, Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.

Semisynthesis of S-desoxybrevetoxin-B2 and brevetoxin-B2, and assessment of their acute toxicities.

J. Cooney, C. Miles, A. Wilkins, 2008, Chemical research in toxicology.

The red tide toxin, brevetoxin, induces embryo toxicity and developmental abnormalities.

J. Ramsdell, J S Ramsdell, K. L. Kimm-Brinson, 2001, Environmental health perspectives.

Dynamics of ciguatoxins from Gambierdiscus polynesiensis in the benthic herbivore Mugil cephalus: Trophic transfer implications

A. Ledreux, M. Bottein, M. Chinain, 2014 .

Multi-Laboratory Study of Five Methods for the Determination of Brevetoxins in Shellfish Tissue Extracts.

M. Wekell, D. Baden, J. Ramsdell, 2004, Harmful algae 2002 : proceedings of the Xth International Conference on Harmful Algae, St. Pete Beach, Florida, USA, October 21-25, 2002. International Conference on Harmful Algae.

Analysis of interactions of brevetoxin-B and human serum albumin by liquid chromatography/mass spectrometry.

J. Ramsdell, Zhihong Wang, 2011, Chemical research in toxicology.

BREVETOXICOSIS IN SEABIRDS NATURALLY EXPOSED TO KARENIA BREVIS BLOOMS ALONG THE CENTRAL WEST COAST OF FLORIDA

J. Ramsdell, Christine K. Johnson, D. Fauquier, 2013, Journal of wildlife diseases.

Bioassay methods for detection of N-palmitoylbrevetoxin-B2 (BTX-B4).

M. Bottein, C. Miles, A. Wilkins, 2010, Toxicon : official journal of the International Society on Toxinology.

Distribution of Brevetoxin (PbTx-3) in Mouse Plasma: Association with High-Density Lipoproteins

J. Ramsdell, P. Spiess, Ricky T. Woofter, 2005, Environmental health perspectives.

Pharmacological effects of the marine toxins, brevetoxin and saxitoxin, on murine frontal cortex neuronal networks.

N. Kulagina, J. Pancrazio, Wu Ma, 2004, Toxicon : official journal of the International Society on Toxinology.

Acute and delayed thermoregulatory response of mice exposed to brevetoxin.

B. Padnos, J. Ramsdell, K. L. Kimm-Brinson, 2001, Toxicon : official journal of the International Society on Toxinology.

Maitotoxin induces a calcium-dependent membrane depolarization in GH4C1 pituitary cells via activation of type L voltage-dependent calcium channels.

J. Ramsdell, F. V. Van Dolah, D. Xi, 1992, The Journal of biological chemistry.

Transforming growth factor-alpha and its receptor are expressed in the epithelium of the rat prostate gland.

T. B. Taylor, J. Ramsdell, T B Taylor, 1993, Endocrinology.

Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1.

E. Levin, A. Rezvani, J. Ramsdell, 2007, Neurotoxicology.

Use of GH4C1 cell variants to demonstrate a non-spare receptor model for thyrotropin-releasing hormone action

J. Ramsdell, A. Tashjian, 1985, Molecular and Cellular Endocrinology.

Brevetoxin in two planktivorous fishes after exposure to Karenia brevis: implications for food-web transfer to bottlenose dolphins

J. Ramsdell, M. Hinton, 2008 .

Alexandrium in the Black Sea — identity, ecology and PSP toxicity

S. Morton, J. Ramsdell, M. Quilliam, 2006 .

Development and preliminary validation of a microtiter plate-based receptor binding assay for paralytic shellfish poisoning toxins.

J. Ramsdell, G. Doucette, F. V. Van Dolah, 1997, Toxicon : official journal of the International Society on Toxinology.

Neuroexcitatory and neurotoxic actions of the amnesic shellfish poison, domoic acid.

T. B. Taylor, J. Ramsdell, R. Switzer, 1994, Neuroreport.

Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats.

A. Ledreux, J. Ramsdell, 2013, Toxicon : official journal of the International Society on Toxinology.

Effects of marine algal toxins on thermoregulation in mice.

J. Ramsdell, C. Gordon, 2005, Neurotoxicology and teratology.

Neuroexcitatory actions of ciguatoxin on brain regions associated with thermoregulation.

T. B. Taylor, J. Ramsdell, P. Moeller, 1995, Neuroreport.

Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response

M. Bottein, J. Ramsdell, F. V. Van Dolah, 2010, BMC Neuroscience.

Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations.

E. Levin, A. Rezvani, J. Ramsdell, 2008, Toxicology.

Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice.

E. Levin, A. Rezvani, J. Ramsdell, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Dopamine receptors on dispersed bovine anterior pituitary cells.

J. Ramsdell, R. Weiner, F. Monnet, 1985, Neuroendocrinology.

Domoic Acid Epileptic Disease

J. Ramsdell, F. Gulland, 2014, Marine drugs.

A Cupric Silver Histochemical Analysis of Domoic Acid Damage to Olfactory Pathways Following Status Epilepticus in a Rat Model for Chronic Recurrent Spontaneous Seizures and Aggressive Behavior

J. Ramsdell, J. Tiedeken, N. Muha, 2013, Toxicologic pathology.

Toxicokinetics of domoic acid in the fetal rat.

J. Ramsdell, Zhihong Wang, N. Muha, 2012, Toxicology.

Maternal–Fetal Transfer of Domoic Acid in Rats at Two Gestational Time Points

J. Ramsdell, J. Maucher, 2007, Environmental health perspectives.

Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats.

E. Levin, J. Ramsdell, P. Williams, 2006, Neurotoxicology and teratology.

Acute phase gene expression in mice exposed to the marine neurotoxin domoic acid

J. Ramsdell, J. Morey, J. Ryan, 2005, Neuroscience.

Persisting behavioral consequences of prenatal domoic acid exposure in rats.

Edward D Levin, E. Levin, J. Ramsdell, 2005, Neurotoxicology and teratology.

Mapping and reconstruction of domoic acid-induced neurodegeneration in the mouse brain.

J. Ramsdell, R. Switzer, T. Trusk, 2005, Neurotoxicology and teratology.

Working memory deficits induced by single but not repeated exposures to domoic acid.

L. Means, E. Clayton, J. Ramsdell, 1999, Toxicon : official journal of the International Society on Toxinology.

Repeated independent exposures to domoic acid do not enhance symptomatic toxicity in outbred or seizure-sensitive inbred mice.

L. Means, E. Clayton, J. Ramsdell, 1997, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Glutamate receptors and calcium entry mechanisms for domoic acid in hippocampal neurons

J. Ramsdell, Dan Xi, 1996, Neuroreport.

Brain Fos induction is a sensitive biomarker for the lowest observed neuroexcitatory effects of domoic acid.

J. Ramsdell, Y. Peng, Y. Peng, 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Elimination kinetics of domoic acid from the brain and cerebrospinal fluid of the pregnant rat.

J. Ramsdell, Zhihong Wang, N. Muha, 2012, Chemical research in toxicology.

Domoic acid induced seizures progress to a chronic state of epilepsy in rats.

J. Ramsdell, N. Muha, 2011, Toxicon : official journal of the International Society on Toxinology.

A transforming growth factor-alpha pathway is expressed in GH4C1 rat pituitary tumors and appears necessary for tumor formation.

E. Finley, J. Ramsdell, 1994, Endocrinology.

Human pituitary somatotropes express transforming growth factor-α and its receptor

E. Finley, J. Ramsdell, J. King, 1994 .

Transforming growth factor-alpha and -beta are potent and effective inhibitors of GH4 pituitary tumor cell proliferation.

J. Ramsdell, 1991, Endocrinology.

Persistent neurological damage associated with spontaneous recurrent seizures and atypical aggressive behavior of domoic acid epileptic disease.

J. Ramsdell, J. Tiedeken, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

CHARACTERIZATION OF ANTERIOR PITUITARY DOPAMINE RECEPTORS

J. Ramsdell, R. Weiner, A. Weisman, 1984 .

Human pituitary somatotropes express transforming growth factor-alpha and its receptor.

E. Finley, J. Ramsdell, J. King, 1994, The Journal of endocrinology.

Tissue distribution of amino acid- and lipid-brevetoxins after intravenous administration to C57BL/6 mice.

J. Ramsdell, T. Leighfield, N. Muha, 2014, Chemical research in toxicology.

Semisynthesis of radiolabeled amino acid and lipid brevetoxin metabolites and their blood elimination kinetics in C57BL/6 mice.

C. Miles, J. Ramsdell, T. Leighfield, 2013, Chemical research in toxicology.

Sample preparation and liquid chromatography-tandem mass spectrometry for the analysis of selected Pacific ciguatoxins in blood samples.

A. Ledreux, J. Ramsdell, Zhihong Wang, 2020, Journal of chromatography. A.

Contaminant-free cultivation of Pfiesteria shumwayae (Dinophyceae) on a fish cell line

J. Burkholder, N. Deamer, J. Ramsdell, 2005 .

HARRNESS : a framework for HAB research and monitoring in the United States for the next decade

Donald M. Anderson, D. Anderson, J. Ramsdell, 2005 .

Ultrasensitive detection of domoic acid in mouse blood by competitive ELISA using blood collection cards.

J. Ramsdell, J. Maucher, Jennifer M Maucher, 2005, Toxicon : official journal of the International Society on Toxinology.

Identification of ciguatoxins in Hawaiian monk seals Monachus schauinslandi from the Northwestern and Main Hawaiian Islands.

M. Bottein, J. Ramsdell, Zhihong Wang, 2011, Environmental science & technology.

Learning impairment caused by a toxin produced by Pfiesteria piscicida infused into the hippocampus of rats.

E. Levin, J. Burkholder, H. Glasgow, 2003, Neurotoxicology and teratology.

Zebrafish Seizure Model Identifies p,p′-DDE as the Dominant Contaminant of Fetal California Sea Lions That Accounts for Synergistic Activity with Domoic Acid

J. Ramsdell, J. Tiedeken, 2009, Environmental health perspectives.

DDT Exposure of Zebrafish Embryos Enhances Seizure Susceptibility: Relationship to Fetal p,p′-DDE Burden and Domoic Acid Exposure of California Sea Lions

J. Ramsdell, J. Tiedeken, 2008, Environmental health perspectives.

Maitotoxin increases voltage independent chloride and sodium currents in GH4C1 rat pituitary cells.

R. Young, J. Ramsdell, M. Mclaren, 1995, Natural toxins.

Permeability of dihydro- and cysteine-brevetoxin metabolites across a Caco-2 cell monolayer

J. Ramsdell, V. Fessard, T. Leighfield, 2014 .

Ultrastructural damage to heart tissue from repeated oral exposure to yessotoxin resolves in 3 months.

T. Yasumoto, J. Ramsdell, A. Giangaspero, 2008, Toxicon : official journal of the International Society on Toxinology.

Brevetoxin B is a clastogen in rats, but lacks mutagenic potential in the SP-98/100 Ames test.

J. Ramsdell, T. Leighfield, N. Muha, 2009, Toxicon : official journal of the International Society on Toxinology.

Azaspiracid-1 inhibits bioelectrical activity of spinal cord neuronal networks.

N. Kulagina, Wu Ma, M. Satake, 2006, Toxicon : official journal of the International Society on Toxinology.

Rat Piriform Cortex: Onset and Propagation Voltage Imaging of Epileptiform Activity in Slices From

Jian-Young Wu, Weifeng Xu, L. Haberly, 2015 .

Behavioral thermoregulatory response to maitotoxin in mice.

J. Ramsdell, Y. Yang, C. Gordon, 1998, Toxicon : official journal of the International Society on Toxinology.

Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice.

E. Levin, A. Rezvani, J. Ramsdell, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

A Cupric Silver Histochemical Analysis of Domoic Acid Damage to Olfactory Pathways Following Status Epilepticus in a Rat Model for Chronic Recurrent Spontaneous Seizures and Aggressive Behavior

J. Ramsdell, J. Tiedeken, N. Muha, 2013, Toxicologic pathology.