A. Ito

发表

Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.

R. Ueoka, K. Shin‐ya, M. Takagi, 2009, Toxicon : official journal of the International Society on Toxinology.

Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.

Minoru Yoshida, A. Ito, M. Islam, 2014, Bioorganic & medicinal chemistry.

An efficient synthesis of SK-658 and its analogs as potent histone deacetylase inhibitors.

Minoru Yoshida, A. Ito, Tamaki Kato, 2015, Bioorganic chemistry.

Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors.

Minoru Yoshida, T. Yamori, A. Ito, 2016, European journal of medicinal chemistry.

New SIRT2 inhibitors: Histidine-based bleomycin spin-off.

Minoru Yoshida, T. Honma, A. Ito, 2019, Bioorganic & medicinal chemistry.

Evaluation of functional groups on amino acids in cyclic tetrapeptides in histone deacetylase inhibition

Minoru Yoshida, A. Ito, M. Islam, 2012, Amino Acids.

Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.

Minoru Yoshida, A. Ito, Tamaki Kato, 2010, Bioorganic & medicinal chemistry letters.

The Modular Nature of Histone Deacetylase HDAC4 Confers Phosphorylation-dependent Intracellular Trafficking*

A. Means, Xuan Zhao, T. Yao, 2001, The Journal of Biological Chemistry.

Live imaging of H 3 K 9 acetylation in plant cells

M. Seki, Minoru Yoshida, A. Ito, 2017 .

Live imaging of H3K9 acetylation in plant cells

H. Kimura, M. Seki, Minoru Yoshida, 2017, Scientific Reports.

Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors.

Kam Y. J. Zhang, Ashutosh Kumar, Minoru Yoshida, 2013, Bioorganic & medicinal chemistry letters.

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.

Minoru Yoshida, John M Denu, J. Denu, 2015, Biochemistry.

Yakushinamides, Polyoxygenated Fatty Acid Amides That Inhibit HDACs and SIRTs, from the Marine Sponge Theonella swinhoei.

Minoru Yoshida, S. Okada, A. Ito, 2016, Journal of natural products.

Charge Modification at Multiple C-terminal Lysine Residues Regulates p53 Oligomerization and Its Nucleus-Cytoplasm Trafficking*

E. Appella, T. Yao, A. Ito, 2006, Journal of Biological Chemistry.

NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis.

A. Iwama, Y. Hayashi, N. Komatsu, 2019, Blood advances.

Attenuation of Macrophage Migration Inhibitory Factor-Stimulated Signaling via S-Nitrosylation.

T. Uehara, A. Ito, M. Asanuma, 2019, Biological & pharmaceutical bulletin.

A genetic screen to discover SUMOylated proteins in living mammalian cells

Minoru Yoshida, A. Ito, H. Saitoh, 2017, Scientific Reports.

Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.

Kam Y. J. Zhang, Jay W. Shin, M. Shirouzu, 2020, International journal of biological macromolecules.

Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation-Inhibitory Activity.

A. Matsuda, Daisuke Sekine, M. Sodeoka, 2019, Chemistry.

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.

K. Ogawa, T. Umehara, S. Yokoyama, 2016, Journal of medicinal chemistry.

Receptor-Independent Ectopic Activity of Prolactin Predicts Aggressive Lung Tumors and Indicates HDACi-Based Therapeutic Strategies.

E. Brambilla, C. Brambilla, Minoru Yoshida, 2015, Antioxidants & redox signaling.

Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods

Kam Y. J. Zhang, Ashutosh Kumar, Minoru Yoshida, 2020, International journal of molecular sciences.

Discovery of small molecule inhibitors targeting the SUMO–SIM interaction using a protein interface consensus approach

Kam Y. J. Zhang, T. Kigawa, A. Voet, 2014 .

4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate

Young-Chae Chang, J. Magae, K. Takeda, 2019, The Journal of Antibiotics.

Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications

Y. Sakakibara, K. Shin‐ya, T. Doi, 2012, BMC chemical biology.

Retusone A, a Guaiane-Type Sesquiterpene Dimer from Wikstroemia retusa and Its Inhibitory Effects on Histone Acetyltransferase HBO1 Expression

A. Ito, H. Fuchino, N. Kawahara, 2022, Molecules.

p 300 / CBP-mediated p 53 acetylation is commonly induced by p 53-activating agents and inhibited by MDM 2

E. Appella, Chun‐Hsiang Lai, Xuan Zhao, 2001 .

Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains.

T. Yao, Minoru Yoshida, A. Ito, 2013, Molecular cell.

Regulation of Histone Deacetylase 6 Activity via S-Nitrosylation.

T. Uehara, A. Ito, K. Okuda, 2015, Biological & pharmaceutical bulletin.

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B

B. Ponder, Yusuke Nakamura, Y. Maehara, 2012, Nature Communications.

Design and synthesis of mono and bicyclic tetrapeptides thioester as potent inhibitor of histone deacetylases

Minoru Yoshida, A. Ito, M. Islam, 2014, Amino Acids.

Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors.

K. Nunomura, Minoru Yoshida, A. Ito, 2022, ACS Medicinal Chemistry Letters.

A Genetically Encoded FRET Probe to Detect Intranucleosomal Histone H3K9 or H3K14 Acetylation Using BRD4, a BET Family Member.

Minoru Yoshida, A. Ito, Y. Nakao, 2016, ACS chemical biology.

Splicing inhibition induces gene expression through canonical NF‐κB pathway and extracellular signal‐related kinase activation

N. Mukaida, Minoru Yoshida, A. Ito, 2014, FEBS letters.

Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†

Minoru Yoshida, A. Ito, E. Mizutani, 2021, Biology of Reproduction.

Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity

Minoru Yoshida, T. Yamori, A. Ito, 2016 .

IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line

M. Komada, T. Asano, N. Kataoka, 2018, Oncotarget.

Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2.

Kam Y. J. Zhang, K. Shin‐ya, Ashutosh Kumar, 2013, ACS chemical biology.

Spectomycin B 1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E 2

Kam Y. J. Zhang, K. Shin‐ya, Ashutosh Kumar, 2013 .

DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes

M. Tagaya, A. Ito, K. Tani, 2020, Frontiers in Cell and Developmental Biology.

Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.

Minoru Yoshida, A. Ito, A. Shah, 2016, Biological & pharmaceutical bulletin.

Steric structure-activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9.

Minoru Yoshida, H. Kagechika, A. Ito, 2016, Bioorganic & medicinal chemistry.

HDAC6 is a microtubule-associated deacetylase

Xiao-Fan Wang, T. Yao, R. Shao, 2002, Nature.

Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6

Minoru Yoshida, A. Ito, Satoko Maeda, 2012, FEBS letters.

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1

T. Tsunoda, Takafumi Suzuki, Masayuki Yamamoto, 2015, Science Signaling.

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap 1

T. Tsunoda, Takafumi Suzuki, Masayuki Yamamoto, 2015 .

Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells.

H. Aburatani, K. Shin‐ya, T. Umehara, 2022, Cell chemical biology.

The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

J. Vance, T. Yao, A. Ito, 2003, Cell.

Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.

Minoru Yoshida, A. Ito, Y. Nagaoka, 2018, ACS medicinal chemistry letters.

PP1C and PP2A are p70S6K Phosphatases Whose Inhibition Ameliorates HLD12-Associated Inhibition of Oligodendroglial Cell Morphological Differentiation

A. Ito, H. Harada, K. Mizoguchi, 2020, Biomedicines.

Transcriptomic analysis of Arabidopsis thaliana plants treated with the Ky-9 and Ky-72 histone deacetylase inhibitors

M. Seki, Minoru Yoshida, A. Ito, 2018, Plant signaling & behavior.

Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.

S. Horinouchi, T. Yao, Minoru Yoshida, 2008, Biochemical and biophysical research communications.

Curacin E from the Brittle Star Ophiocoma scolopendrina.

R. Ueoka, Minoru Yoshida, S. Okada, 2016, Journal of natural products.

A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

T. Umehara, M. Shirouzu, Y. Shinkai, 2023, Nature Communications.

Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity.

M. Sodeoka, Minoru Yoshida, A. Ito, 2010, Journal of the American Chemical Society.

Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.

Minoru Yoshida, A. Ito, M. Islam, 2014, Bioorganic & medicinal chemistry.

17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1

A. Ito, Satoshi Yotsumoto, Katsunori Miyake, 2022, Journal of Natural Medicines.

MDM2–HDAC1‐mediated deacetylation of p53 is required for its degradation

Yoshiharu Kawaguchi, Ettore Appella, E. Appella, 2002, The EMBO journal.

Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A)

Minoru Yoshida, A. Ito, Satoko Maeda, 2012, FEBS letters.

Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.

H. Seno, Takeshi Kimura, T. Chiba, 2018, JCI insight.

Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells*

N. Komatsu, A. Ito, Marito Araki, 2017, The Journal of Biological Chemistry.

Epigenetics: Bioprobes that Target Epigenetic Modifications

Minoru Yoshida, A. Ito, 2017 .

Design and synthesis of peptide-MCA substrates for a novel assay of histone methyltransferases and their inhibitors.

Minoru Yoshida, A. Ito, N. Nishino, 2014, Bioorganic & medicinal chemistry.

Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification.

M. Sodeoka, Minoru Yoshida, A. Ito, 2013, Bioorganic & medicinal chemistry letters.

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

K. Shin‐ya, Y. Shinkai, M. Takagi, 2012, The Journal of Antibiotics.

Bach1 inhibits oxidative stress–induced cellular senescence by impeding p53 function on chromatin

T. Noda, Y. Katoh, Minoru Yoshida, 2008, Nature Structural &Molecular Biology.

Naturally occurring small molecule compounds that target histone deacetylases and their potential applications in cancer therapy

A. Ito, Yuki Maemoto, Yuki Shimizu, 2021, The Journal of Antibiotics.

Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity.

Minoru Yoshida, T. Yamori, A. Ito, 2014, European journal of medicinal chemistry.

Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.

Minoru Yoshida, T. Yamori, A. Ito, 2013, European journal of medicinal chemistry.

The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response1[OPEN]

M. Seki, Minoru Yoshida, A. Ito, 2017, Plant Physiology.

Histone deacetylase inhibitors block nuclear factor‐κB‐dependent transcription by interfering with RNA polymerase II recruitment

K. Ogawa, S. Horinouchi, Minoru Yoshida, 2011, Cancer science.

UBE1a Suppresses Herpes Simplex Virus-1 Replication

M. Fujimuro, Y. Sekine, A. Ito, 2020, Viruses.

Identification of zinc finger transcription factor EGR2 as a novel acetylated protein.

Minoru Yoshida, A. Ito, Y. Nakao, 2017, Biochemical and biophysical research communications.

Identification of ryuvidine as a KDM5A inhibitor

T. Mizukami, S. Wada, M. Hasegawa, 2019, Scientific Reports.

Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis

Kam Y. J. Zhang, S. Lipton, T. Katagiri, 2023, Nature Communications.

Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.

T. Umehara, M. Shirouzu, Minoru Yoshida, 2023, Journal of medicinal chemistry.

The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

Minoru Yoshida, A. Ito, Satoko Maeda, 2012, Bioscience, biotechnology, and biochemistry.

Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.

Minoru Yoshida, Shinichi Nishimura, Hisashi Kawasaki, 2009, Chemistry & biology.

Identification of 1, 2, 5-Oxadiazoles as a New Class of SENP2 Inhibitors Using Structure Based Virtual Screening

Minoru Yoshida, Ashutosh Kumar, Kam Y. J. Zhang, 2014, J. Chem. Inf. Model..

Establishment of a high-throughput detection system for DNA demethylating agents

T. Ushijima, N. Hattori, Minoru Yoshida, 2018, Epigenetics.

Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine

T. Umehara, Minoru Yoshida, H. Kagechika, 2018, ChemMedChem.

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

Y. Saeki, Keiji Tanaka, T. Asano, 2012, Biochemical and biophysical research communications.

Chemical and structural biology of protein lysine deacetylases

Minoru Yoshida, A. Ito, S. Kosono, 2017, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression

D. Levens, T. Tomonaga, H. Matsubara, 2012, Molecular Cancer Research.

Cascade Reaction in Human Live Tissue Allows Clinically Applicable Diagnosis of Breast Cancer Morphology

Katsunori Tanaka, S. Noguchi, E. Morii, 2018, Advanced science.

Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement

Minoru Yoshida, A. Ito, M. Otsuka, 2019, Molecules.

The role of class I histone deacetylase (HDAC) on gluconeogenesis in liver.

E. Araki, Minoru Yoshida, A. Ito, 2011, Biochemical and biophysical research communications.

S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein.

T. Uehara, A. Ito, K. Uchida, 2020, Biochemical and biophysical research communications.

Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors.

T. Umehara, S. Yokoyama, T. Terada, 2011, Chemistry & biology.

The dynamics of histone H2A ubiquitination in HeLa cells exposed to rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage.

M. Fujimuro, A. Ito, Tadashi Watanabe, 2016, Biochemical and biophysical research communications.

Herpes simplex virus 1 infection induces ubiquitination of UBE1a.

M. Fujimuro, A. Ito, Tadashi Watanabe, 2020, The Biochemical journal.

Cyclic tetrapeptides with –SS– bridging between amino acid side chains for potent histone deacetylases’ inhibition

Minoru Yoshida, A. Ito, N. Nishino, 2013, Amino Acids.

Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.

Minoru Yoshida, A. Ito, M. Hoque, 2012, Bioorganic & medicinal chemistry letters.

Design and synthesis of mono and bicyclic tetrapeptides thioester as potent inhibitor of histone deacetylases

Minoru Yoshida, A. Ito, M. Islam, 2014, Amino Acids.

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

K. Shin‐ya, Y. Shinkai, M. Takagi, 2014, The Journal of Antibiotics.

Development of live-cell imaging probes for monitoring histone modifications.

Minoru Yoshida, A. Ito, K. Sasaki, 2012, Bioorganic & medicinal chemistry.

Expression Gene c-myc Repressor Serves as a Molecular Switch for SAP 155-Mediated Splicing of FUSE-Binding Protein-Interacting

D. Levens, T. Tomonaga, H. Matsubara, 2012 .

Signaling and Regulation SAP 155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression

D. Levens, T. Tomonaga, H. Matsubara, 2012 .

Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2

Minoru Yoshida, A. Ito, N. Kudo, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

Eukaryotic translation initiation factor 5A (eIF5A) is essential for HIF-1α activation in hypoxia.

Minoru Yoshida, A. Ito, M. Ishfaq, 2016, Biochemical and biophysical research communications.

Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Minoru Yoshida, A. Ito, N. Kudo, 2017, The Journal of Antibiotics.

Identification of Sumoylation Inhibitors Targeting a Predicted Pocket in Ubc9

Minoru Yoshida, Ashutosh Kumar, Kam Y. J. Zhang, 2014, J. Chem. Inf. Model..

Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.

Minoru Yoshida, A. Ito, M. Otsuka, 2020, Bioorganic & medicinal chemistry letters.

Identification of new SUMO activating enzyme 1 inhibitors using virtual screening and scaffold hopping.

Minoru Yoshida, Kam Y. J. Zhang, Ashutosh Kumar, 2016, Bioorganic & medicinal chemistry letters.

Improving reactivity of naphthalimide-based GST probe by imparting TPP cation: Development and application for live cell imaging.

Y. Fujikawa, A. Ito, Yuki Maemoto, 2022, Bioorganic & medicinal chemistry letters.

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

H. Handa, Y. Yamaguchi, Minoru Yoshida, 2014, The Journal of Antibiotics.

Kerriamycin B inhibits protein SUMOylation

Minoru Yoshida, Hiroyuki Osada, Hisashi Kawasaki, 2009, The Journal of Antibiotics.

Lysine long-chain fatty acylation regulates the TEAD transcription factor.

T. Umehara, M. Sodeoka, Takehiro Suzuki, 2023, Cell reports.

Bicyclic tetrapeptide histone deacetylase inhibitors with methoxymethyl ketone and boronic acid zinc-binding groups.

Minoru Yoshida, A. Ito, M. Islam, 2014, Bioorganic chemistry.

A genetic screen to discover SUMOylated proteins in living mammalian cells

Minoru Yoshida, A. Ito, H. Saitoh, 2017, Scientific Reports.

Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses.

Y. Shinkai, M. Sodeoka, Minoru Yoshida, 2018, Chemical communications.

Assay methods for small ubiquitin-like modifier (SUMO)-SUMO-interacting motif (SIM) interactions in vivo and in vitro using a split-luciferase complementation system.

Kam Y. J. Zhang, A. Voet, Minoru Yoshida, 2014, Analytical Biochemistry.

Assay methods for SUMO–SIM interactions in vivo and in vitro using a split-luciferase complementation system

Kam Y. J. Zhang, A. Voet, Minoru Yoshida, 2013 .

The dynamics of histone H 2 A ubiquitination in HeLa cells exposed to rapamycin , ethanol , hydroxyurea , ER stress , heat shock and DNA damage

M. Fujimuro, A. Ito, Tadashi Watanabe, 2016 .

Identification of Sumoylation Activating Enzyme 1 Inhibitors by Structure-Based Virtual Screening

Minoru Yoshida, Ashutosh Kumar, Kam Y. J. Zhang, 2013, J. Chem. Inf. Model..

Efficient N-Acyldopamine Synthesis.

M. Uesugi, A. Ito, Yotaro Matsumoto, 2016, Chemical & pharmaceutical bulletin.