C. Cadenas

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Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction

Marcel H. Schulz, Thomas Lengauer, B. Hutter, 2016, bioRxiv.

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction

Thomas Lengauer, Florian Schmidt, Marcel H. Schulz, 2016, bioRxiv.

A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains

Thomas Lengauer, F. Ramírez, J. Walter, 2018, Genome Biology.

Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high‐resolution magic angle spinning 1H NMR spectroscopy

J. Rahnenführer, K. Edlund, J. Hengstler, 2018, NMR in biomedicine.

Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway

J. Rahnenführer, K. Edlund, J. Hengstler, 2017, Analytical and Bioanalytical Chemistry.

Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice

Christian H. Holland, U. Hofmann, S. Dooley, 2021, Hepatology communications.

Adverse outcome pathways: opportunities, limitations and open questions

S. H. Bennekou, F. Oesch, S. Dooley, 2017, Archives of Toxicology.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Wolfgang Moritz, Wiebke Albrecht, Tim Brecklinghaus, 2019, Archives of Toxicology.

Prognostic signatures of breast cancer: Perou's molecular subtypes and Schmidt's metagenes

C. Cadenas, 2012, EXCLI journal.

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

J. Rahnenführer, K. Edlund, O. Taboureau, 2018, Archives of Toxicology.

CRUP: a comprehensive framework to predict condition-specific regulatory units

M. Vingron, J. Walter, Ho-Ryun Chung, 2019, Genome Biology.

Separation and identification of phospholipids by hydrophilic interaction liquid chromatography coupled to tandem high resolution mass spectrometry with focus on isomeric phosphatidylglycerol and bis(monoacylglycero)phosphate.

C. Cadenas, H. Hayen, Christian Vosse, 2018, Journal of chromatography. A.

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

W. Schmidt-Heck, C. Hetz, J. Hengstler, 2014, Archives of Toxicology.

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds.

Alison J. Foster, Dominic P. Williams, J. Rahnenführer, 2021, Chemico-biological interactions.

Partially methylated domains are hallmarks of a cell specific epigenome topology

Thomas Lengauer, F. Ramírez, J. Walter, 2018, bioRxiv.

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis

J. Walter, I. Leclercq, J. Hengstler, 2019, Front. Med..

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells.

J. Rahnenführer, K. Edlund, N. Blüthgen, 2022, Journal of hepatology.

CRUP: a comprehensive framework to predict condition-specific regulatory units

Martin Vingron, Ho-Ryun Chung, Thomas Manke, 2018, Genome Biology.

Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis

J. Rahnenführer, J. Hengstler, C. Cadenas, 2016, Archives of Toxicology.

differentiationphenotyping of a model of adipocyte

J. Hengstler, F. Tinahones, A. Vidal-Puig, 2015 .

In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red Assay.

J. Rahnenführer, K. Edlund, J. Hengstler, 2022, Toxicology letters.

Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response

J. Rahnenführer, J. Hengstler, C. Cadenas, 2014, Breast Cancer.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

J. Rahnenführer, K. Edlund, L. Kuepfer, 2019, Archives of Toxicology.

Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study

M. Nitsche, E. Wascher, J. Hengstler, 2021, JMIR research protocols.

Dortmund Vital Study: a protocol of an interdisciplinary cross-sectional and longitudinal study to evaluate impact of biological and lifestyle factors on cognitive aging and work ability (Preprint)

M. Nitsche, E. Wascher, J. Hengstler, 2021 .

Oxalic acid quantification in mouse urine and primary mouse hepatocyte cell culture samples by ion exclusion chromatography-mass spectrometry.

A. Schriewer, Kathrin Gianmoena, C. Cadenas, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Key messages of recent publications in the field of toxicology

R. Marchan, C. Cadenas, P. Godoy, 2012, EXCLI journal.

Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

J. Rahnenführer, Marcus Schmidt, J. Hengstler, 2012, BMC Cancer.

Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

C. Lindskog, J. Rahnenführer, K. Edlund, 2023, Journal of Experimental & Clinical Cancer Research.

A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains

Thomas Lengauer, F. Ramírez, J. Walter, 2018, Genome Biology.

Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma.

J. Rahnenführer, K. Edlund, J. Hengstler, 2017, Cancer research.

Unique Metabolic Features of Stem Cells, Cardiomyocytes, and Their Progenitors

J. Hengstler, C. Cadenas, J. Hescheler, 2014, Circulation research.

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy

J. Rahnenführer, K. Edlund, Marcus Schmidt, 2016, PloS one.

ERBB2 overexpression triggers transient high mechanoactivity of breast tumor cells

J. Käs, J. Hengstler, C. Cadenas, 2012, Cytoskeleton.

The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer.

L. Holmberg, J. Rahnenführer, F. Pontén, 2013, Cancer letters.

Loss of circadian clock gene expression is associated with tumor progression in breast cancer

J. Rahnenführer, K. Edlund, Marcus Schmidt, 2014, Cell cycle.

Editorial: CARCINOGENESIS IN TOXICOLOGICAL RESEARCH

C. Cadenas, 2011 .

Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer

K. Ickstadt, J. Rahnenführer, Marcus Schmidt, 2010, Breast Cancer Research.

A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin κ C as a Compatible Prognostic Marker in Human Solid Tumors

L. Holmberg, J. Rahnenführer, K. Edlund, 2012, Clinical Cancer Research.

normR: Regime enrichment calling for ChIP-seq data

Ho-Ryun Chung, Na Li, Thomas Manke, 2016, bioRxiv.

Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity

J. Hengstler, S. Hoehme, A. Ghallab, 2022, Archives of Toxicology.

Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression

Christian H. Holland, T. Luedde, U. Hofmann, 2021, Cells.

Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria.

E. Salido, P. Boor, A. Schriewer, 2021, Cell reports.

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

R. Vadigepalli, J. Hoek, K. Edlund, 2020, Archives of Toxicology.

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

Nils Blüthgen, Reinhard Guthke, Jan G. Hengstler, 2016, Archives of Toxicology.

Fatty Acid Elongation in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma

F. Lammert, R. Bohle, J. Hengstler, 2014, International journal of molecular sciences.

Hydrophilic interaction liquid chromatography tandem mass spectrometry analysis of malonyl-coenzyme A in breast cancer cell cultures applying online solid-phase extraction.

A. Schriewer, C. Cadenas, H. Hayen, 2017, Journal of separation science.

Marker in Human Solid Tumors C as a Compatible Prognostic κ Identifies Stromal Immunoglobulin A Comprehensive Analysis of Human Gene Expression Profiles

L. Holmberg, K. Edlund, H. Bojar, 2012 .

Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene

J. Walter, Wei Chen, P. Durek, 2016, The Journal of Immunology.

Immunoglobulin Kappa C Predicts Overall Survival in Node-Negative Breast Cancer

Marcus Schmidt, J. Hengstler, M. Gehrmann, 2012, PloS one.

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits.

Wiebke Schormann, Jan G Hengstler, Jonathan West, 2011, Lab on a chip.

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

R. Vadigepalli, J. Hoek, K. Edlund, 2020, Archives of Toxicology.

Glycerophospholipid profile in oncogene-induced senescence.

J. Rahnenführer, Z. Török, J. Hengstler, 2012, Biochimica et biophysica acta.

Zinc as a multipurpose trace element

C. Cadenas, H. Bolt, R. Marchan, 2012, Archives of Toxicology.

Genetic determinants of steatosis and fibrosis progression in paediatric non‐alcoholic fatty liver disease

H. Holzhütter, C. Loddenkemper, J. Hengstler, 2019, Liver international (Print).

Gene Expression–Based Prediction of Neoadjuvant Chemotherapy Response in Early Breast Cancer: Results of the Prospective Multicenter EXPRESSION Trial

J. Rahnenführer, K. Edlund, S. Loibl, 2021, Clinical Cancer Research.

Highlight report: toxicology of copper

C. Cadenas, 2015, Archives of Toxicology.

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

Wolfgang Moritz, Wiebke Albrecht, Tim Brecklinghaus, 2018, Archives of Toxicology.

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

J. Rahnenführer, K. Edlund, O. Taboureau, 2018, Archives of Toxicology.

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

W. Schmidt-Heck, C. Hetz, J. Hengstler, 2014, Archives of Toxicology.

LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer

A. Schriewer, J. Rahnenführer, F. Pontén, 2019, International journal of cancer.

Gelsolin Is Associated with Longer Metastasis-free Survival and Reduced Cell Migration in Estrogen Receptor-positive Breast Cancer.

Jan G Hengstler, Jörg Rahnenführer, Karolina Edlund, 2015, Anticancer research.

Estrogen receptors in human disease

C. Cadenas, H. Bolt, 2012, Archives of Toxicology.

Zinc as a multipurpose trace element

C. Cadenas, H. Bolt, R. Marchan, 2012, Archives of Toxicology.

Role of heat shock proteins in stress response and carcinogenesis

C. Cadenas, H. Bolt, R. Marchan, 2012, Archives of Toxicology.

Buckyballs (fullerenes): free radical sponges or inflammatory agents?

J. Hengstler, C. Cadenas, R. Marchan, 2012, Archives of Toxicology.

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation

J. Hengstler, A. Ghallab, A. Mally, 2023, Archives of Toxicology.

' s response to reviews Title : Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

J. Hengstler, M. Gehrmann, C. Solbach, 2012 .

Alterations in the hepatocyte epigenetic landscape in steatosis

Marcel H. Schulz, Ranjan Kumar Maji, P. Rosenstiel, 2023, Epigenetics & Chromatin.

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

J. Rahnenführer, K. Edlund, J. Hengstler, 2018, Archives of Toxicology.

A user-friendly guide on how to obtain and accurately interpret information from metabolic databases

R. Marchan, C. Cadenas, C. Cadenas, 2011, Archives of Toxicology.

Highlight report: toxicology of copper

C. Cadenas, 2015, Archives of Toxicology.

Editorial: KEY MESSAGES OF RECENT PUBLICATIONS IN THE FIELD OF TOXICOLOGY

C. Cadenas, N. Schöbel, Rosemarie Marchan, 2012 .