H. Ayyub

发表

A Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter

Vip Viprakasit, Jan-Fang Cheng, Edward M. Rubin, 2006, Science.

Genetic dissection of the α-globin super-enhancer in vivo

L. Pennacchio, J. Telenius, J. Hughes, 2016, Nature Genetics.

SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data

Åsa Hedman, John Broxholme, Jiannis Ragoussis, 2005, Nucleic acids research.

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

A. Jarman, D. Higgs, J. Sharpe, 1991, Molecular and cellular biology.

Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the α-thalassemia myelodysplasia syndrome (ATMDS)

C. Langford, D. Higgs, H. Ayyub, 2003, Nature Genetics.

Healing of broken human chromosomes by the addition of telomeric repeats.

H. Williams, D. Higgs, H. Ayyub, 1994, American journal of human genetics.

Alpha thalassaemia in British people.

A. Hill, J. Clegg, D. Weatherall, 1985, British medical journal.

Chromosomal stabilisation by a subtelomeric rearrangement involving two closely related Alu elements.

L. Kearney, D. Higgs, S. Horsley, 1996, Human molecular genetics.

Analysis of the human a-globin gene cluster reveals a highly informative genetic locus ( haplotype / genetic linkage / recombinatlon / polymorphism )

A. Hill, J. Flint, J. Clegg, 2022 .

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

D. Higgs, H. Ayyub, R. Gibbons, 2015, Nature Communications.

A novel deletion causing alpha thalassemia clarifies the importance of the major human alpha globin regulatory element.

D. Higgs, V. Viprakasit, H. Ayyub, 2006, Blood.

Hb H hydrops fetalis syndrome associated with the interaction of two common determinants of α thalassaemia (‐‐MED/αTSaudiα)

D. Higgs, V. Viprakasit, H. Ayyub, 2002, British journal of haematology.

A large deletion in the human alpha-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype.

D. Higgs, J. Sloane-Stanley, C. Fisher, 2008, Human molecular genetics.

α‐thalassaemia in the North West of England

D. Higgs, H. Ayyub, M. Bhavnani, 1989 .

The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats

T. Jenuwein, D. Higgs, J. Sharpe, 2017, EMBO reports.

major human alpha globin regulatory element thalassemia clarifies the importance of the α A novel deletion causing

D. Higgs, V. Viprakasit, H. Ayyub, 2012 .

Monosomy for the most telomeric, gene-rich region of the short arm of human chromosome 16 causes minimal phenotypic effects

J. Peden, L. Kearney, D. Higgs, 2001, European Journal of Human Genetics.

Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.

D. Higgs, S. Liebhaber, J. Horst, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin

P. Vyas, D. Higgs, H. Ayyub, 1992, Cell.

Molecular Rearrangements of the Human α‐Globin Gene Cluster

A. Hill, S. Goodbourn, J. Clegg, 1985, Annals of the New York Academy of Sciences.

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

Steven J. M. Jones, J. Ragoussis, I. Dunham, 2010, Cell.

Linkage analysis of nondeletion hereditary persistence of fetal hemoglobin.

J. Clegg, D. Weatherall, H. Ayyub, 1982, Science.

Alpha‐thalassaemia in Nigeria: Its interaction with sickle‐cell disease

D. Higgs, H. Ayyub, A. Falusi, 1987, European journal of haematology.

Dinucleotide deletion in –α3.7 allele causes a severe form of α+ thalassaemia

V. Viprakasit, H. Ayyub, A. May, 2003, European journal of haematology.

Alpha thalassaemia and extended alpha globin genes in Sri Lanka.

D. Weatherall, N. Olivieri, C. Fisher, 2013, Blood cells, molecules & diseases.

α Thalassaemia in two Spanish families

D. Higgs, H. Ayyub, M. Vickers, 1990 .

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.

A. Hill, J. Flint, D. Higgs, 1986, Proceedings of the National Academy of Sciences of the United States of America.

A new method to assess the statistical significance of copy number changes identified in genomic DNA by array comparative genome hybridization

R. Regan, R. Mott, J. Flint, 2003 .

DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease

E. Li, J. Hughes, D. Higgs, 2017, Proceedings of the National Academy of Sciences.

Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease

D. Higgs, J. Sharpe, H. Ayyub, 2003, Nature Genetics.

alpha-thalassemia resulting from a negative chromosomal position effect.

D. Higgs, J. Sharpe, J. Sloane-Stanley, 2000, Blood.

De novo deletion within the telomeric region flanking the human α globin locus as a cause of α thalassaemia

J. Hughes, D. Higgs, S. Horsley, 2003, British journal of haematology.

Analysis of the human alpha globin upstream regulatory element (HS‐40) in transgenic mice.

D. Higgs, J. Sharpe, H. Ayyub, 1992, The EMBO journal.

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

D. Higgs, H. Ayyub, R. Gibbons, 2000, Nature Genetics.

Analysis of Sequence Variation Underlying Tissue‐specific Transcription Factor Binding and Gene Expression

J. Hughes, D. Higgs, J. Sloane-Stanley, 2013, Human mutation.

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

A. Jarman, D. Higgs, J. Sharpe, 1990, Genes & development.

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

J. Hughes, D. Higgs, J. Sharpe, 2012, The EMBO journal.

The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.

I. Dunham, Christoph M. Koch, D. Higgs, 2008, Blood.

Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.

P. Vyas, D. Higgs, J. Sharpe, 1995, The EMBO journal.

ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells

D. Higgs, H. Ayyub, R. Gibbons, 2014, PloS one.

Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.

A. Wilkie, D. Higgs, J. Sharpe, 1990, Blood.

On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation

D. Higgs, J. Sharpe, J. Sloane-Stanley, 2021, bioRxiv.

Identification of MAZ as a novel transcription factor regulating erythropoiesis

M. Mann, J. Sloane-Stanley, H. Ayyub, 2020, bioRxiv.

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition

Vip Viprakasit, Chris Fisher, Douglas R Higgs, 2009, Proceedings of the National Academy of Sciences.

a-Thalassemia Caused by a Large ( 62 kb ) Deletion Upstream of the Human a Globin Gene Cluster

Sharpe, V. Buckle, H. Ayyub, 2003 .

Alpha thalassaemia in two Spanish families.

D. Higgs, H. Ayyub, M. Vickers, 1990, European journal of haematology.

Analysis ofthehumana-globin genecluster reveals ahighly informative genetic locus

A. Hill, J. Flint, J. Clegg, 1986 .

Identification of the transcription factor MAZ as a regulator of erythropoiesis.

M. Mann, J. Sloane-Stanley, H. Ayyub, 2021, Blood advances.

Characterization oftheMajorRegulatory Element Upstream ofthe Humana-Globin GeneCluster

H. Ayyub, 1991 .

The −−THAI and −−FIL determinants of α thalassemia in Taiwan

D. Higgs, H. Ayyub, Douglas R. Higgs, 1999, American journal of hematology.

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

J. Hughes, D. Higgs, J. Sharpe, 2012, EMBO Journal.

Alpha-thalassaemia in the north west of England.

D. Higgs, H. Ayyub, M. Bhavnani, 1989, Clinical and laboratory haematology.

The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.

I. Dunham, Christoph M. Koch, D. Higgs, 2008, Blood.