H. Hosokawa

发表

Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network

William J R Longabaugh, Ali Mortazavi, Hao Yuan Kueh, 2017, Proceedings of the National Academy of Sciences.

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

K. Nakayama, Tomoaki Tanaka, M. Matsumoto, 2018, Immunity.

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium

M. Ohtsuka, K. Ando, H. Hosokawa, 2022, Frontiers in Immunology.

NF-AT-Mediated Expression of TGF-β1 in Tolerant T Cells1

H. Hosokawa, N. Hozumi, N. Nakano, 2007, The Journal of Immunology.

Methylation of Gata3 Protein at Arg-261 Regulates Transactivation of the Il5 Gene in T Helper 2 Cells*

K. Nakayama, Tomoaki Tanaka, M. Matsumoto, 2015, The Journal of Biological Chemistry.

Lymphoid enhancer factor interacts with GATA‐3 and controls its function in T helper type 2 cells

H. Hosokawa, M. Taniguchi, T. Nakayama, 2008, Immunology.

Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells

K. Nakayama, Tomoaki Tanaka, M. Matsumoto, 2016, Nature Communications.

The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells.

Yutaka Suzuki, K. Tokoyoda, H. Hosokawa, 2013, Immunity.

Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells.

M. Miyazaki, H. Hosokawa, T. Nakayama, 2007, Molecular immunology.

Nanoparticulation of BCG-CWS for application to bladder cancer therapy.

H. Nishiyama, H. Akaza, Toshihiro Ito, 2014, Journal of controlled release : official journal of the Controlled Release Society.

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.

Toshiro K. Ohsumi, R. Geha, J. Chou, 2013, The Journal of allergy and clinical immunology.

Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity

Yutaka Suzuki, H. Hosokawa, T. Nakayama, 2013, PloS one.

Apoptosis of Effector Th2 Cells in the Lung through the Inhibition of Bim-Mediated Regulates Th2-Driven Airway Inflammation Group Gene Product Ring1B Polycomb

K. Tokoyoda, H. Hosokawa, H. Koseki, 2010 .

Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene

A. Iwama, H. Hosokawa, T. Nakayama, 2008, The Journal of experimental medicine.

AMBRA1 controls antigen-driven activation and proliferation of naïve T cells.

M. Kimura, M. Ohtsuka, I. Inoue, 2020, International immunology.

Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development

D. Tenen, A. Iwama, H. Hosokawa, 2014, Nature Communications.

Notch signaling supports the appearance of follicular helper T cells in the Peyer's patches concomitantly with the reduction of regulatory T cells.

H. Hosokawa, K. Hozumi, Jin Imai, 2021, International immunology.

CD69 Controls the Pathogenesis of Allergic Airway Inflammation1

H. Hosokawa, T. Nakayama, M. Shirai, 2009, The Journal of Immunology.

Cytokines, Transcription Factors, and the Initiation of T-Cell Development.

H. Hosokawa, E. Rothenberg, 2018, Cold Spring Harbor perspectives in biology.

Regulation of Th2 Cell Development by Polycomb Group Gene bmi-1 through the Stabilization of GATA31

H. Hosokawa, H. Koseki, T. Nakayama, 2006, The Journal of Immunology.

Regulation of T helper type 2 cell differentiation by murine Schnurri-2

S. Ishii, H. Hosokawa, M. Taniguchi, 2005, The Journal of experimental medicine.

Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells

H. Hosokawa, K. Hozumi, K. Hirano, 2022, The Journal of biological chemistry.

Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172.

Y. Ishii, Toshihiro Ito, H. Hosokawa, 2008, International immunology.

Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis

K. Yamagata, I. Manabe, K. Yokote, 2022, Nature Communications.

Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci*

Maki Ukai-Tadenuma, T. Miyamoto, J. DeGregori, 2004, Journal of Biological Chemistry.

Impaired GATA3-Dependent Chromatin Remodeling and Th2 Cell Differentiation Leading to Attenuated Allergic Airway Inflammation in Aging Mice1

H. Hosokawa, T. Nakayama, M. Kimura, 2006, The Journal of Immunology.

Inflammation in Aging Mice Leading to Attenuated Allergic Airway Remodeling and Th2 Cell Differentiation Impaired GATA3-Dependent Chromatin

H. Hosokawa, T. Nakayama, M. Kimura, 2006 .

CD69-null mice protected from arthritis induced with anti-type II collagen antibodies.

S. Ziegler, H. Hosokawa, M. Taniguchi, 2003, International immunology.

GLS2 is a tumor suppressor and a regulator of ferroptosis in hepatocellular carcinoma.

B. Stockwell, C. Prives, K. Yokote, 2022, Cancer research.

Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching

Wen Zhou, H. Hosokawa, Maile Romero-Wolf, 2021, Proceedings of the National Academy of Sciences.

Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression

Yutaka Suzuki, Tomoaki Tanaka, H. Hosokawa, 2013, Proceedings of the National Academy of Sciences.

Murine Schnurri-2 controls natural killer cell function and lymphoma development

K. Mitsumori, H. Hosokawa, T. Nakayama, 2012, Leukemia & lymphoma.

Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells.

Y. Okamoto, H. Hosokawa, T. Nakayama, 2012, Clinical immunology.

Chromatin remodeling of the Th2 cytokine gene loci

H. Hosokawa, T. Nakayama, M. Kitajima, 2005 .

DNA vaccine using invariant chain gene for delivery of CD4+ T cell epitope peptide derived from Japanese cedar pollen allergen inhibits allergen‐specific IgE response

H. Hosokawa, M. Kasai, M. Sakaguchi, 2002, European journal of immunology.

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

S. Sugano, Yutaka Suzuki, C. Prives, 2010, Proceedings of the National Academy of Sciences.

Enhanced Th2 Cell Differentiation and Allergen-Induced Airway Inflammation in Zfp35-Deficient Mice1

O. Ohara, H. Hosokawa, H. Koseki, 2009, The Journal of Immunology.

Deficient Mice Zfp 35 Allergen-Induced Airway Inflammation in Enhanced Th 2 Cell Differentiation and Ohara

O. Ohara, H. Hosokawa, H. Koseki, 2009 .

Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

S. Sugano, Yutaka Suzuki, Tomoaki Tanaka, 2013, Proceedings of the National Academy of Sciences.

Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation

Y. Okamoto, K. Tokoyoda, H. Hosokawa, 2016, Science Immunology.

Th2 Cells in Health and Disease.

Y. Okamoto, H. Hosokawa, T. Nakayama, 2017, Annual review of immunology.

LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

K. Ando, H. Hosokawa, K. Hozumi, 2021, eLife.

How transcription factors drive choice of the T cell fate

H. Hosokawa, E. Rothenberg, 2020, Nature reviews. Immunology.

How transcription factors drive choice of the T cell fate

H. Hosokawa, E. Rothenberg, 2020, Nature Reviews Immunology.

Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells

Tomoaki Tanaka, H. Hosokawa, Maile Romero-Wolf, 2021, The Journal of experimental medicine.

Transcription factors regulate early T cell development via redeployment of other factors

H. Hosokawa, Kaori Masuhara, Maria Koizumi, 2021, BioEssays : news and reviews in molecular, cellular and developmental biology.

Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development

H. Hosokawa, E. Rothenberg, J. Ungerbäck, 2019, Front. Immunol..

Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)

B. Williams, M. Sigvardsson, H. Hosokawa, 2018, bioRxiv.

Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.

C. Chazaud, H. Hosokawa, T. Nakayama, 2012, Genes & development.

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells

Yutaka Suzuki, H. Hosokawa, T. Nakayama, 2010, The Journal of experimental medicine.

Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.

H. Hosokawa, T. Nakayama, M. Kimura, 2006, Immunity.

Type II membrane protein CD69 regulates the formation of resting T-helper memory

K. Tokoyoda, A. Radbruch, H. Hosokawa, 2012, Proceedings of the National Academy of Sciences.

Anti-IgE autoantibody in patients with atopic dermatitis.

T. Koike, H. Hosokawa, Y. Nawata, 1985, Journal of Immunology.

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

V. Lefebvre, H. Hosokawa, T. Nakayama, 2012, Nature Immunology.

cAMP activation by PACAP/VIP stimulates IL‐6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells

Tomoaki Tanaka, I. Tatsuno, H. Hosokawa, 2009, Journal of cellular physiology.

Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development

Wen Zhou, H. Hosokawa, Maile Romero-Wolf, 2020, The Journal of cell biology.

Establishment of a new three‐dimensional human epidermal model reconstructed from plucked hair follicle‐derived keratinocytes

O. Ohara, H. Hosokawa, T. Nakayama, 2016, Experimental dermatology.

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

K. Nakayama, Tomoaki Tanaka, M. Matsumoto, 2018, Nature Immunology.

Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3.

Masakatsu Yamashita, Toshinori Nakayama, Akane Suzuki, 2011, Immunity.

Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer.

I. Yoshino, H. Hosokawa, T. Nakayama, 2018, Biochemical and biophysical research communications.

Genome-Wide Analysis Reveals Unique Regulation of Transcription of Th2-Specific Genes by GATA3

S. Sugano, Yutaka Suzuki, Tomoaki Tanaka, 2011, The Journal of Immunology.

STAT6-Dependent Differentiation and Production of IL-5 and IL-13 in Murine NK2 Cells1

T. Miyamoto, H. Hosokawa, M. Taniguchi, 2004, The Journal of Immunology.

Gfi1-mediated Stabilization of GATA3 Protein Is Required for Th2 Cell Differentiation*

H. Hosokawa, T. Nakayama, M. Yamashita, 2008, Journal of Biological Chemistry.

Polycomb Group Gene Product Ring1B Regulates Th2-Driven Airway Inflammation through the Inhibition of Bim-Mediated Apoptosis of Effector Th2 Cells in the Lung

K. Tokoyoda, H. Hosokawa, H. Koseki, 2010, The Journal of Immunology.

Critical YxKxHxxxRP Motif in the C-Terminal Region of GATA3 for Its DNA Binding and Function1

H. Hosokawa, T. Nakayama, M. Yamashita, 2006, The Journal of Immunology.

Production of IL-5 and IL-13 in Murine NK 2 STAT 6-Dependent Differentiation and Taniguchi and Toshinori

T. Miyamoto, H. Hosokawa, M. Taniguchi, 2004 .

CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA.

Maki Ukai-Tadenuma, H. Hosokawa, M. Taniguchi, 2003, Immunity.

Cell type–specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells

Tomoaki Tanaka, H. Hosokawa, Maile Romero-Wolf, 2019, The Journal of experimental medicine.

Explorer Bmi 1 facilitates primitive endoderm formation by stabilizing Gata 6 during early mouse development

C. Chazaud, H. Hosokawa, T. Nakayama, 2018 .

IL‐4‐mediated development of TGF‐β1‐producing cells from naïve CD4+ T cells through a STAT6‐independent mechanism

M. Kubo, H. Hosokawa, N. Hozumi, 2001, European journal of immunology.

Erratum: Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding (Immunity (2018) 48(6) (1119–1134.e7), (S1074761318301936) (10.1016/j.immuni.2018.04.024))

K. Nakayama, Tomoaki Tanaka, M. Matsumoto, 2018 .

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells

Yutaka Suzuki, H. Hosokawa, T. Nakayama, 2010, The Journal of experimental medicine.

during early mouse development Bmi 1 facilitates primitive endoderm formation by stabilizing Gata 6 Material Supplemental

C. Chazaud, H. Hosokawa, T. Nakayama, 2012 .

Bmi 1 facilitates primitive endoderm formation by stabilizing Gata 6 during early mouse development

C. Chazaud, H. Hosokawa, T. Nakayama, 2012 .

GLS2 is a tumor suppressor and a regulator of ferroptosis 1 in hepatocellular carcinoma

B. Stockwell, C. Prives, K. Yokote, 2022 .