H. Ly

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Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors

Morgan Brisse, H. Ly, Morgan E Brisse, 2019, Front. Immunol..

Human Hemorrhagic Fever Causing Arenaviruses: Molecular Mechanisms Contributing to Virus Virulence and Disease Pathogenesis

H. Ly, Junjie Shao, Yuying Liang, 2015, Pathogens.

Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections.

H. Ly, Yuying Liang, L. McLay, 2014, The Journal of general virology.

Antibody Responses against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model

E. Hunter, H. Ly, T. Parslow, 2011, PloS one.

Host-Directed Antiviral Therapy

Shalini Sharma, B. Rouse, B. N. Tripathi, 2020, Clinical Microbiology Reviews.

congenita telomerase RNA template gene (TERC) in a patient with dyskeratosis Identification and functional characterization of 2 variant alleles of the

P. Lansdorp, Q. Ouyang, H. Ly, 2013 .

Telomere Dysfunction in Human Genetic Disease

H. Ly, Garrett Morgan, Garrett R Morgan, 2011 .

Telomere dysfunction in human diseases: the long and short of it!

H. Ly, K. Carroll, K. A. Carroll, 2009, International journal of clinical and experimental pathology.

Review Article Telomere Dysfunction in Human Diseases: The Long and Short of It!

H. Ly, K. Carroll, K. A. Carroll, 2009 .

Identification and functional characterization of novel telomerase variant alleles in Japanese patients with bone-marrow failure syndromes.

H. Ly, K. Dan, H. Yamaguchi, 2008, Blood cells, molecules & diseases.

Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita.

E. Blackburn, P. Lansdorp, Q. Ouyang, 2005, Blood.

Cap binding and immune evasion revealed by Lassa nucleoprotein structure

H. Ly, Yuying Liang, Haohao Dong, 2010, Nature.

Recombinant SARS-CoV-2 Nucleocapsid Protein: Expression, Purification, and Its Biochemical Characterization and Utility in Serological Assay Development to Assess Immunological Responses to SARS-CoV-2 Infection

H. Ly, Yuying Liang, Da Di, 2021, Pathogens.

Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5

Morgan Brisse, H. Ly, Morgan E Brisse, 2019, Front. Immunol..

Evaluation of Cellular Determinants Required for In Vitro Xenotropic Murine Leukemia Virus-Related Virus Entry into Human Prostate Cancer and Noncancerous Cells

E. Hunter, H. Ly, Yuying Liang, 2010, Journal of Virology.

Peste Des Petits Ruminants Virus Infection of Small Ruminants: A Comprehensive Review

Shalini Sharma, H. Ly, S. K. Kashyap, 2014, Viruses.

Differential Immune Responses to New World and Old World Mammalian Arenaviruses

H. Ly, 2017, International journal of molecular sciences.

Development of Infectious Clones for Virulent and Avirulent Pichinde Viruses: a Model Virus To Study Arenavirus-Induced Hemorrhagic Fevers

H. Ly, Yuying Liang, Naveen Kumar, 2009, Journal of Virology.

Hearing loss in outbred Hartley guinea pigs experimentally infected with Pichinde virus as a surrogate model of human mammarenaviral hemorrhagic fevers

Morgan Brisse, H. Ly, Yuying Liang, 2022, Virulence.

Molecular Determinants of Pichinde Virus Infection of Guinea Pigs—a Small Animal Model System for Arenaviral Hemorrhagic Fevers

H. Ly, Yuying Liang, S. Lan, 2009, Annals of the New York Academy of Sciences.

Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production

H. Ly, Junjie Shao, Yuying Liang, 2018, Journal of Virology.

Evaluating the Biological Role of Lassa Viral Z Protein-Mediated RIG-I Inhibition Using a Replication-Competent Trisegmented Pichinde Virus System in an Inducible RIG-IN Expression Cell Line

H. Ly, Yuying Liang, Qinfeng Huang, 2022, Journal of virology.

Inhibition of Innate Immune Responses Is Key to Pathogenesis by Arenaviruses

H. Ly, B. Meyer, Bjoern Meyer, 2016, Journal of Virology.

Genome comparison of virulent and avirulent strains of the Pichinde arenavirus

H. Ly, Yuying Liang, L. McLay, 2008, Archives of Virology.

Biological Characterization of Conserved Residues within the Cytoplasmic Tail of the Pichinde Arenaviral Glycoprotein Subunit 2 (GP2)

Morgan Brisse, H. Ly, Junjie Shao, 2019, Journal of Virology.

High-Resolution Structure of the N-Terminal Endonuclease Domain of the Lassa Virus L Polymerase in Complex with Magnesium Ions

H. Ly, Yuying Liang, Qinfeng Huang, 2014, PloS one.

NF- (cid:2) B Signaling Differentially Regulates Inﬂuenza Virus RNA Synthesis (cid:1)

H. Ly, Yuying Liang, Z. Xin, 2008 .

Development of a Recombinant Pichinde Virus-Vectored Vaccine against Turkey Arthritis Reovirus and Its Immunological Response Characterization in Vaccinated Animals

S. Goyal, H. Ly, Yuying Liang, 2021, Pathogens.

Recombinant Tri-Segmented Pichinde Virus as a Novel Live Viral Vaccine Platform.

H. Ly, Yuying Liang, Rekha Dhanwani, 2017, Methods in molecular biology.

A Novel Live Pichinde Virus-Based Vaccine Vector Induces Enhanced Humoral and Cellular Immunity after a Booster Dose

H. Ly, Yuying Liang, Qinfeng Huang, 2015, Journal of Virology.

Immune evasion mechanisms of arenaviruses

H. Ly, Yuying Liang, 2015, Oncotarget.

Effect of Strain Variations on Lassa Virus Z Protein-Mediated Human RIG-I Inhibition

Morgan Brisse, H. Ly, Yuying Liang, 2020, Viruses.

Animal Models of Lassa Fever

H. Ly, S. Paessler, Cheng Huang, 2020, Pathogens.

Assays to Assess Arenaviral Glycoprotein Function.

H. Ly, Junjie Shao, Yuying Liang, 2018, Methods in molecular biology.

Characterization of the Glycoprotein Stable Signal Peptide in Mediating Pichinde Virus Replication and Virulence

H. Ly, Junjie Shao, Yuying Liang, 2016, Journal of Virology.

Functional characterization of mutations in the promoter proximal region of the telomerase hTERC gene identified in patients with hematological disorders.

H. Ly, K. A. Carroll, 2011, International journal of clinical and experimental medicine.

Influenza A virus activates cellular Tropomyosin receptor kinase A (TrkA) signaling to promote viral replication and lung inflammation

H. Ly, Yuying Liang, Qinfeng Huang, 2022, PLoS pathogens.

Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemia.

S. Chanock, S. Savage, N. Young, 2006, Experimental hematology.

Characterization of immunological responses in patients with severe fever with thrombocytopenia syndrome: a cohort study in China.

W. Liu, W. Cao, H. Ly, 2015, Vaccine.

XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH.

F. Marshall, A. Osunkoya, E. Hunter, 2010, Urology.

correspondence: Identification of TINF2 gene mutations in adult Japanese patients with acquired bone marrow failure syndromes

H. Ly, K. Inokuchi, K. Dan, 2010, British journal of haematology.

Establishment of Bisegmented and Trisegmented Reverse Genetics Systems to Generate Recombinant Pichindé Viruses.

H. Ly, Junjie Shao, Yuying Liang, 2018, Methods in molecular biology.

Characterization of virulence-associated determinants in the envelope glycoprotein of Pichinde virus.

H. Ly, Yuying Liang, Naveen Kumar, 2012, Virology.

Biological Roles and Functional Mechanisms of Arenavirus Z Protein in Viral Replication

H. Ly, Yuying Liang, Naveen Kumar, 2012, Journal of Virology.

Receptor Tyrosine Kinase Inhibitors That Block Replication of Inﬂuenza A and Other Viruses (cid:1)

H. Ly, Yuying Liang, T. Parslow, 2011 .

Immunogenicity and Protective Efficacy of a Recombinant Pichinde Viral-Vectored Vaccine Expressing Influenza Virus Hemagglutinin Antigen in Pigs

P. Gauger, Hiep L. X. Vu, H. Ly, 2022, Vaccines.

patients with hematologic disorders Functional characterization of telomerase RNA variants found in

P. Lansdorp, R. Calado, H. Ly, 2012 .

Telomerase regulation in HTLV-I infection.

H. Ly, 2008, Blood.

Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes

M. Khan, H. Ly, T. Parslow, 2005, Journal of Virology.

Understanding the prevalence of SARS-CoV-2 (COVID-19) exposure in companion, captive, wild, and farmed animals

H. Ly, Hannah Murphy, 2021, Virulence.

SARS-CoV-2 in companion animals: Do levels of SARS-CoV-2 seroconversion in pets correlate with those of pet’s owners and with protection against subsequent SARS-CoV-2 infection?

H. Ly, Yuying Liang, Da Di, 2022, Virulence.

Mutational Analyses of Packaging Signals in Inﬂuenza Virus PA, PB1, and PB2 Genomic RNA Segments (cid:1)

H. Ly, Yuying Liang, T. Parslow, 2007 .

Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain

H. Ly, Yuying Liang, Junji Xing, 2015, Journal of Virology.

Absence of pathogenic mutations of the human telomerase RNA gene (hTERC) in patients with chronic myeloproliferative disorders

H. Ly, A. Ferraris, S. Park, 2006, Leukemia.

Virulent infection of outbred Hartley guinea pigs with recombinant Pichinde virus as a surrogate small animal model for human Lassa fever

W. Shieh, H. Ly, Yuying Liang, 2020, Virulence.

RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection

Morgan Brisse, H. Ly, Yuying Liang, 2021, Frontiers in Immunology.

Understanding Immune Responses to Lassa Virus Infection and to Its Candidate Vaccines

H. Ly, Hannah Murphy, 2022, Vaccines.

Pichinde Virus Infection of Outbred Hartley Guinea Pigs as a Surrogate Animal Model for Human Lassa Fever: Histopathological and Immunohistochemical Analyses

W. Shieh, H. Ly, Yuying Liang, 2020, Pathogens.

Epidemiological, serological, and genetic evidence of influenza D virus infection in humans: Is it a justifiable cause for concern?

H. Ly, Widaliz Vega-Rodriguez, 2022, Virulence.

Telomere dynamics in induced pluripotent stem cells: Potentials for human disease modeling.

H. Ly, 2011, World journal of stem cells.

Emerging Concepts and Technologies in Vaccine Development

Morgan Brisse, H. Ly, Yuying Liang, 2020, Frontiers in Immunology.

In Vitro and In Vivo Characterizations of Pichinde Viral Nucleoprotein Exoribonuclease Functions

H. Ly, Junjie Shao, Yuying Liang, 2015, Journal of Virology.

The Z Proteins of Pathogenic but Not Nonpathogenic Arenaviruses Inhibit RIG-i-Like Receptor-Dependent Interferon Production

Yuying Liang, H. Ly, Yuying Liang, 2014, Journal of Virology.

Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression*

H. Ly, Yuying Liang, Qinfeng Huang, 2013, The Journal of Biological Chemistry.

Development and Applications of Viral Vectored Vaccines to Combat Zoonotic and Emerging Public Health Threats

Morgan Brisse, H. Ly, Yuying Liang, 2020, Vaccines.

Expression and X-Ray Structural Determination of the Nucleoprotein of Lassa Fever Virus.

H. Ly, Yuying Liang, Haohao Dong, 2018, Methods in molecular biology.

Comprehensive Structure-Function Analysis of the Core Domain of Human Telomerase RNA

E. Blackburn, H. Ly, T. Parslow, 2003, Molecular and Cellular Biology.

A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein.

Mira Abraham, Jue Lin, E. Blackburn, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Transcriptional Activation of TINF2, a Gene Encoding the Telomere-Associated Protein TIN2, by Sp1 and NF-κB Factors

H. Ly, Naveen Kumar, Z. Xin, 2011, PloS one.

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.

S. Chanock, P. Lansdorp, S. Kajigaya, 2005, The New England journal of medicine.

Genetic and environmental factors influencing human diseases with telomere dysfunction.

H. Ly, 2009, International journal of clinical and experimental medicine.

Bipartite Signal for Genomic RNA Dimerization in Moloney Murine Leukemia Virus

H. Ly, T. Parslow, 2002, Journal of Virology.

Moloney Murine Sarcoma Virus Genomic RNAs Dimerize via a Two-Step Process: a Concentration-Dependent Kissing-Loop Interaction Is Driven by Initial Contact between Consecutive Guanines

J. Olsen, D. Nierlich, H. Ly, 1999, Journal of Virology.

Receptor Tyrosine Kinase Inhibitors That Block Replication of Influenza A and Other Viruses

Naveen Kumar, Yuying Liang, H. Ly, 2011, Antimicrobial Agents and Chemotherapy.

NF-κB Signaling Differentially Regulates Influenza Virus RNA Synthesis

H. Ly, Yuying Liang, Z. Xin, 2008, Journal of Virology.

Functional Characterization of the Dimer Linkage Structure RNA of Moloney Murine Sarcoma Virus

A. Kaplan, J. Olsen, D. Nierlich, 2000, Journal of Virology.

The potential risks posed by inter- and intraspecies transmissions of monkeypox virus

H. Ly, Hannah Murphy, 2022, Virulence.

Pathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments

H. Ly, Hannah Murphy, 2021, Virulence.

Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever.

H. Ly, Yuying Liang, L. McLay, 2013, Antiviral research.

Roles of Arenavirus Z Protein in Mediating Virion Budding, Viral Transcription-Inhibition and Interferon-Beta Suppression.

H. Ly, Junjie Shao, Yuying Liang, 2018, Methods in molecular biology.

Emergence of deadly viral haemorrhagic fever disease outbreaks in West Africa

H. Ly, Widaliz Vega-Rodriguez, 2023, Virulence.

Identification of Virulence Determinants within the L Genomic Segment of the Pichinde Arenavirus

H. Ly, Yuying Liang, L. McLay, 2013, Journal of Virology.

Lassa Fever: Viral Replication, Disease Pathogenesis, and Host Immune Modulations

H. Ly, 2020, Pathogens.

Langya henipavirus: Is it a potential cause for public health concern?

H. Ly, Shania Sanchez, 2023, Virulence.

COVID-19 evolution during the pandemic – Implications of new SARS-CoV-2 variants on disease control and public health policies

N. Hall, H. Ly, C. van Oosterhout, 2021, Virulence.

Functional characterization of telomerase RNA variants found in patients with hematologic disorders.

P. Lansdorp, N. Young, R. Calado, 2005, Blood.

Functional characterization of natural telomerase mutations found in patients with hematologic disorders.

Yuying Liang, Peter M Lansdorp, Adam Beauchamp, 2007, Blood.

Immunosuppressive arenaviral exoribonuclease

H. Ly, B. Meyer, 2015, Oncotarget.

Characterization of Chikungunya Virus Induced Host Response in a Mouse Model of Viral Myositis

Mohsin Khan, H. Ly, M. Parida, 2014, PloS one.

Failure of Japanese encephalitis vaccine and infection in inducing neutralizing antibodies against West Nile virus, People's Republic of China.

W. Liu, Hong Yang, W. Cao, 2008, The American journal of tropical medicine and hygiene.

Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells.

R. Terns, M. Terns, C. Counter, 2008, Molecular biology of the cell.

Functional Characterization of Yeast Telomerase RNA Dimerization*

H. Ly, T. Parslow, Z. Xin, 2007, Journal of Biological Chemistry.

Advances in Development and Application of Influenza Vaccines

H. Ly, Jipei Zhang, Jidang Chen, 2021, Frontiers in Immunology.

Recombinant Pichinde viral vector expressing tuberculosis antigens elicits strong T cell responses and protection in mice

Anna D. Tischler, H. Ly, Yuying Liang, 2023, Frontiers in Immunology.

PLC-γ1 Signaling Plays a Subtype-Specific Role in Postbinding Cell Entry of Influenza A Virus

Liqian Zhu, H. Ly, Yuying Liang, 2013, Journal of Virology.

Mutational Analyses of Packaging Signals in Influenza Virus PA, PB1, and PB2 Genomic RNA Segments

H. Ly, Yuying Liang, T. Parslow, 2007, Journal of Virology.

A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase.

E. Blackburn, H. Ly, T. Parslow, 2003, Genes & development.

SARS‐CoV‐2 infection of kidney tissues in some severe and fatal cases of COVID‐19

H. Ly, 2023, Journal of Medical Virology.

IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese

W. Liu, Hong Yang, W. Cao, 2008, PloS one.

GETTING AHEAD OF MONKEYPOX: Learning from the COVID‐19 pandemic experience to prevent the potentially new monkeypox pandemic

H. Ly, Widaliz Vega-Rodriguez, 2022, Journal of medical virology.

Emerging Pteropine orthoreoviruses and their potential impact on public health

H. Ly, Widaliz Vega-Rodriguez, 2023, Journal of medical virology.

COVID-19 adaptive evolution during the pandemic – Implications of new SARS-CoV-2 variants on public health policies

B. Weimer, H. Ly, C. van Oosterhout, 2021, Virulence.

Seroprevalence of SARS-CoV-2 (COVID-19) exposure in pet cats and dogs in Minnesota, USA

H. Ly, Yuying Liang, Qinfeng Huang, 2021, Virulence.

The RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegans

D. Baillie, R. Johnsen, H. Ly, 2004, The Journal of cell biology.

First genome report and analysis of chicken H7N9 influenza viruses with poly-basic amino acids insertion in the hemagglutinin cleavage site

H. Ly, M. Cai, Jipei Zhang, 2017, Scientific Reports.

Recent Discoveries of Novel Mammarenaviruses Infecting Humans and Other Mammals in Asia and Southeast Asia

H. Ly, M. Cain, Brigitte Flannery, 2023, Virulence.

Functional Characterization of Telomerase RNA Variants Found in Patients with Hematological Disorders.

P. Lansdorp, N. Young, R. Calado, 2004 .

Functional characterization of natural telomerase mutations found in patients with hematological disorders

N. Young, R. Calado, H. Ly, 2006 .

Increasing evidence of human infections by the neurotropic Borna disease virus 1 (BoDV-1)

H. Ly, M. Cain, 2023, Virulence.

The ever-expanding diversity and complexity of the Arenaviridae family

H. Ly, 2023, Virulence.

Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections.

H. Ly, Yuying Liang, L. McLay, 2014, The Journal of general virology.

Comparative Pathology of Animal Models for Influenza A Virus Infection

H. Ly, Natalie M Kirk, Natalie M. Kirk, 2023, Pathogens.

Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19

H. Ly, Natalie M Kirk, Yuying Liang, 2024, Virulence.

What are the risk levels of humans contracting SARS‐CoV‐2 from pets and vice versa?

H. Ly, Hannah Murphy, 2022, Journal of medical virology.

XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH.

F. Marshall, A. Osunkoya, E. Hunter, 2010, Urology.

Host‐directed antiviral strategy: The potential of SYK inhibitor R406 against influenza A virus infection

H. Ly, Widaliz Vega-Rodriguez, 2024, Journal of medical virology.

GBP1, an interferon-inducible GTPase, inhibits Hantaan viral entry by restricting clathrin-mediated endocytosis.

H. Ly, Morgan E Brisse, 2024, Journal of medical virology.

Characterization of bi-segmented and tri-segmented recombinant Pichinde virus particles.

H. Ly, Qinfeng Huang, Hannah Murphy, 2024, Journal of virology.