Dan Zhou

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Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations

Christopher D. Brown, K. White, A. Jha, 2015, Molecular biology and evolution.

New Insights into the Genetic Basis of Monge’s Disease and Adaptation to High-Altitude

E. Kirkness, V. Bafna, J. Venter, 2017, Molecular biology and evolution.

Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes

Ye Yin, Vineet Bafna, Roy Ronen, 2014, Genome Biology.

Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia

Lei Xie, P. Bourne, Li Xie, 2013, BMC Genomics.

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

Yuan-Xiang Pan, Dan Zhou, Xiyuan Zhang, 2018, Genes & Nutrition.

Identification of Genes Underlying Hypoxia Tolerance in Drosophila by a P-element Screen

G. Haddad, Dan Zhou, Priti Azad, 2012, G3: Genes | Genomes | Genetics.

Experimental Selection for Drosophila Survival in Extremely High O2 Environments

Gabriel G. Haddad, V. Nizet, G. Haddad, 2007, PloS one.

Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders.

Yu Wang, Vineet Bafna, Kelly A. Frazer, 2013, American journal of human genetics.

Exploring miRNA-mRNA regulatory network in cardiac pathology in Na+/H+ exchanger isoform 1 transgenic mice.

G. Haddad, Dan Zhou, O. Poulsen, 2018, Physiological genomics.

Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy.

G. Haddad, M. Karmazyn, Dan Zhou, 2010, Physiological genomics.

Ultrastructural Modifications in the Mitochondria of Hypoxia-Adapted Drosophila melanogaster

Mark Ellisman, G. Perkins, Siqi Liu, 2012, PloS one.

Drosophila, a Golden Bug, for the Dissection of the Genetic Basis of Tolerance and Susceptibility to Hypoxia

G. Haddad, Dan Zhou, Deeann W Visk, 2009, Pediatric Research.

Gestational low protein diet selectively induces the amino acid response pathway target genes in the liver of offspring rats through transcription factor binding and histone modifications.

Yuan-Xiang Pan, Dan Zhou, Yuan-Xiang Pan, 2011, Biochimica et biophysica acta.

Mechanisms Regulating Hypoxia Tolerance in Drosophila and Humans

G. Haddad, Dan Zhou, T. Stobdan, 2021 .

Epigenetics, a signal sensor of dietary components, is involved in the hepatic gene regulation

Dan Zhou, 2014 .

Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus.

M. Erion, D. Kelley, Dan Zhou, 2016, American journal of physiology. Endocrinology and metabolism.

73 – Basic Mechanisms of Oxygen Sensing and Response to Hypoxia

G. Haddad, Dan Zhou, 2017 .

Chapter 88 – Basic Mechanisms of Oxygen-Sensing and Response to Hypoxia

G. Haddad, Dan Zhou, 2004 .

Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2.

B. Gelb, G. Haddad, H. Yao, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Experimental selection of hypoxia-tolerant Drosophila melanogaster

Ali Bashir, Vineet Bafna, Shankar Subramaniam, 2011, Proceedings of the National Academy of Sciences.

Genetic interactions regulate hypoxia tolerance conferred by activating Notch in excitatory amino acid transporter 1-positive glial cells in Drosophila melanogaster

G. Haddad, Dan Zhou, T. Stobdan, 2021, G3.

Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice

V. Bafna, A. McCulloch, R. Ronen, 2015, Proceedings of the National Academy of Sciences of the United States of America.

Intermittent Hypoxia and Hypercapnia Reproducibly Change the Gut Microbiome and Metabolome across Rodent Model Systems

R. Knight, P. Dorrestein, A. Malhotra, 2019, mSystems.

A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats.

Yuan-Xiang Pan, Yukun Zhang, Dan Zhou, 2011, The Journal of nutrition.

Leptin and Metabolic Control of Reproduction

Dan Zhou, J. E. Schneider, R. M. Blum, 2000, Hormones and Behavior.

Voluntary exercise augments acute effects of CB1-receptor inverse agonist on body weight loss in obese and lean mice

Dan Zhou, L. Shearman, 2004, Pharmacology Biochemistry and Behavior.

Induction of autophagy through the activating transcription factor 4 (ATF4)-dependent amino acid response pathway in maternal skeletal muscle may function as the molecular memory in response to gestational protein restriction to alert offspring to maternal nutrition

Huan Wang, Yuan-Xiang Pan, Dan Zhou, 2015, British Journal of Nutrition.

Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death.

Matthew A. Zapala, N. Schork, Jiyi Wang, 2008, Physiological genomics.

Interactive effects of central leptin and peripheral fuel oxidation on estrous cyclicity.

Dan Zhou, J. E. Schneider, 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring.

Yuan-Xiang Pan, Dan Zhou, R. Strakovsky, 2010, The Journal of nutrition.

Title Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis , Partially via Trimethylamine-Oxide Permalink

R. Knight, P. Dorrestein, A. Malhotra, 2017 .

Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis, Partially via Trimethylamine‐Oxide

R. Knight, P. Dorrestein, A. Malhotra, 2017, American journal of respiratory cell and molecular biology.

DIDS protects against neuronal injury by blocking Toll‐like receptor 2 activated‐mechanisms

G. Haddad, H. Yao, Dan Zhou, 2009, Journal of neurochemistry.

Role of transporters and ion channels in neuronal injury under hypoxia.

G. Haddad, H. Yao, Dan Zhou, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

Quantitative Evaluation of the Mitochondrial Proteomes of Drosophila melanogaster Adapted to Extreme Oxygen Conditions

Mark H. Ellisman, Quanhui Wang, Bo Wen, 2013, PloS one.

Na+/H+ exchanger 1 deficiency alters gene expression in mouse brain.

G. Haddad, Dan Zhou, Jin Xue, 2004, Physiological genomics.

Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia

Alexander T. Williams, G. Haddad, Dan Zhou, 2018, Journal of Molecular Medicine.

ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge’s disease

V. Bafna, N. Spann, G. Haddad, 2022, Experimental & Molecular Medicine.

Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor- (cid:2) B kinase subunit (cid:3) -dependent atherosclerosis in pulmonary arteries

M. Karin, G. Haddad, Dan Zhou, 2019 .

Methadone alters transcriptional programs associated with synapse formation in human cortical organoids

Dan Zhou, Andrew B. Caldwell, S. Subramaniam, 2022, bioRxiv.

Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome

Rob Knight, Pieter C. Dorrestein, Daniel McDonald, 2018, mSystems.

Expression analysis of photosynthesis-related genes in albino Artocarpus heterophyllus seedlings leaves

Dan Zhou, Lu Cao, Xi Zhang, 2020, bioRxiv.

Hypoxia-Adaptation Involves Mitochondrial Metabolic Depression and Decreased ROS Leakage

G. Haddad, Dan Zhou, Huiwen W. Zhao, 2012, PloS one.

Modulation of hSlo BK current inactivation by fatty acid esters of CoA

G. Haddad, H. Yao, Dan Zhou, 2008, Journal of neurochemistry.

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression.

Huan Wang, Hong Chen, Yuan-Xiang Pan, 2015, The Journal of nutritional biochemistry.

Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis

Jacob D. Feala, Andrew D. McCulloch, Giovanni Paternostro, 2009, BMC Systems Biology.

Experimental Selection for Drosophila Survival in Extremely Low O2 Environment

K. White, G. Haddad, Dan Zhou, 2007, PloS one.

Hypoxia increases BK channel activity in the inner mitochondrial membrane.

G. Haddad, X. Gu, Dan Zhou, 2007, Biochemical and biophysical research communications.

Fat Accumulation in the Liver of Obese Rats is Alleviated by Soy Protein Isolate through β-catenin signaling

Jeremy E. Davis, Huan Wang, Hong Chen, 2013, Obesity.

Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes

V. Bafna, K. Frazer, Guangwu Guo, 2014, Genome Biology.

Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats

Hong Chen, Yukun Zhang, Dan Zhou, 2012, British Journal of Nutrition.

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat.

Laura Moody, Huan Wang, Hong Chen, 2015, Physiological genomics.

High-altitude adaptation in humans: from genomics to integrative physiology

V. Bafna, G. Haddad, A. Akbari, 2017, Journal of Molecular Medicine.

Effect of carbon dioxide on neonatal mouse lung: a genomic approach.

G. Haddad, A. Kanaan, J. Ryu, 2006, Journal of applied physiology.

High fat diet induces sex-specific differential gene expression in Drosophila melanogaster

D. Sahoo, G. Haddad, Dan Zhou, 2019, PloS one.

Transcriptional Response to Hypoxia in Developing Brain

Dan Zhou, 2009 .

Mechanisms Underlying Hypoxia Tolerance in Drosophila melanogaster: hairy as a Metabolic Switch

Kevin P. White, Nicholas J. Schork, Gabriel G. Haddad, 2008, PLoS genetics.

Severe Hypoxia: Consequences to Neural Stem Cells and Neurons.

A. Muotri, E. Snyder, G. Haddad, 2011, Journal of neurology research.

Pathophysiological basis for compromised health beyond generations: role of maternal high-fat diet and low-grade chronic inflammation.

Dan Zhou, Yuan-Xiang Pan, 2015, The Journal of nutritional biochemistry.

Maternal Protein and Fat Intake: Epigenetic Consequences on Fetal Development

Huan Wang, Hong Chen, Dan Zhou, 2014 .

Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster

V. Bafna, S. Kryazhimskiy, G. Haddad, 2021, Nature Communications.

Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits

P. Michalak, G. Haddad, A. Korol, 2015, BMC Biology.

Distinct Mechanisms Underlying Tolerance to Intermittent and Constant Hypoxia in Drosophila melanogaster

Gabriel G. Haddad, G. Haddad, Dan Zhou, 2009, PloS one.

modelhistone modifications in a diet-induced obese rat Hepatic cellular senescence pathway genes are induced

Yukun Zhang, Dan Zhou, Xiyuan Zhang, 2016 .

rat model through histone modifications in a diet-induced obese Hepatic cellular senescence pathway genes are induced

Yukun Zhang, Dan Zhou, Xiyuan Zhang, 2013 .

Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model.

Yukun Zhang, Dan Zhou, Xiyuan Zhang, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Intermittent Hypoxia and Hypercapnia Alter Diurnal Rhythms of Luminal Gut Microbiome and Metabolome

Emmanuel O. Elijah, P. Dorrestein, A. C. Dantas Machado, 2021, mSystems.

Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats

Dan Zhou, Xiyuan Zhang, Yuan-Xiang Pan, 2011, The Journal of physiology.

High-altitude adaptation in humans: from genomics to integrative physiology

V. Bafna, G. Haddad, A. Akbari, 2017, Journal of Molecular Medicine.

Enhanced running wheel activity of both Mch1r- and Pmch-deficient mice

Dan Zhou, L. Shearman, D. Marsh, 2005, Regulatory Peptides.

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats.

M. Bednarek, D. Macintyre, Dan Zhou, 2003, European journal of pharmacology.

Influence of Intermittent Hypoxia/Hypercapnia on Atherosclerosis, Gut Microbiome, and Metabolome

Emmanuel O. Elijah, R. Knight, P. Dorrestein, 2021, Frontiers in Physiology.

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio[S]

Manabu T. Nakamura, Xingguo Wang, Dan Zhou, 2016, Journal of Lipid Research.

Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders

E. Kirkness, V. Bafna, J. Venter, 2018, European Journal of Human Genetics.

Intermittent Hypoxia and Hypercapnia Induces Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta-dependent Atherosclerosis in Pulmonary Arteries.

M. Karin, G. Haddad, Dan Zhou, 2019, American journal of physiology. Regulatory, integrative and comparative physiology.

The Skeletal Muscle Wnt Pathway May Modulate Insulin Resistance and Muscle Development in a Diet‐Induced Obese Rat Model

Dan Zhou, Xiyuan Zhang, Yuan-Xiang Pan, 2012, Obesity.

Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro.

A. Muotri, G. Haddad, Dan Zhou, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Microbiota Modulates Cardiac Transcriptional Responses to Intermittent Hypoxia and Hypercapnia

L. Eckmann, G. Haddad, Dan Zhou, 2021, Frontiers in Physiology.

The genetic basis of chronic mountain sickness.

V. Bafna, R. Ronen, G. Haddad, 2014, Physiology.

A Genomic Approach to Understanding Chronic Mountain Sickness

V. Bafna, R. Ronen, G. Haddad, 2014 .

Antimicrobial Peptides Increase Tolerance to Oxidant Stress in Drosophila melanogaster*

G. Haddad, Dan Zhou, Huiwen W. Zhao, 2010, The Journal of Biological Chemistry.

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats.

Dan Zhou, Xiyuan Zhang, Yuan-Xiang Pan, 2014, The Journal of nutritional biochemistry.

Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans.

G. Haddad, Dan Zhou, 2013, Annual review of genomics and human genetics.

Intermittent Hypoxia and Hypercapnia Accelerate Aorta and Pulmonary Artery Atherosclerosis, partially Mediated via Trimethylamine‐Oxide (TMAO) in both ApoE−/− and Ldlr−/− Mice on High Fat Diet

A. Malhotra, Dan Zhou, O. Poulsen, 2017 .

Wnt Pathway Activation Increases Hypoxia Tolerance during Development

S. Subramaniam, M. Gersten, G. Haddad, 2014, PloS one.

The role of GABA in the regulation of copulatory behavior in male Syrian hamsters

Dan Zhou, 1998 .

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

Dan Zhou, Xiyuan Zhang, G. Xu, 2018, Genes & nutrition.

Long noncoding RNA HIKER regulates erythropoiesis in Monge’s disease via CSNK2B

T. Rana, D. Traver, Dan Zhou, 2023, The Journal of clinical investigation.

The Sodium-Activated Potassium Channel Slack (Slo 2.2) is Modulated by Hypercapnia and Acidosis

R. Douglas, C. Trouth, G. Haddad, 2019 .

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge’s disease

V. Bafna, R. Ronen, G. Haddad, 2016, The Journal of experimental medicine.

Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia.

G. Haddad, J. Lai, Dan Zhou, 2005, Physiological genomics.

Dickkopf homolog 1, a Wnt signaling antagonist, is transcriptionally up-regulated via an ATF4-independent and MAPK/ERK-dependent pathway following amino acid deprivation.

Hong Chen, Yukun Zhang, Dan Zhou, 2011, Biochimica et biophysica acta.

Expression of Na+/H+ and HCO3 −-dependent transporters in Na+/H+ exchanger isoform 1 null mutant mouse brain

R. Douglas, W. Boron, G. Haddad, 2003, Neuroscience.

Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis

A. McCulloch, L. Coquin, J. Feala, 2009, BMC Systems Biology.

Translating animal model research: does it matter that our rodents are cold?

V. Bafna, J. Knuuti, M. Grocott, 2014, Physiology.

Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia

Alexander T. Williams, G. Haddad, Dan Zhou, 2018, Journal of Molecular Medicine.

Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis

A. McCulloch, L. Coquin, J. Feala, 2009, BMC Systems Biology.

Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro.

A. Muotri, G. Haddad, Dan Zhou, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders

E. Kirkness, V. Bafna, J. Venter, 2018, European Journal of Human Genetics.

Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders.

V. Bafna, K. Frazer, Guangwu Guo, 2013, American journal of human genetics.

Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits

P. Michalak, G. Haddad, A. Korol, 2015, BMC Biology.

Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia

P. Bourne, Li Xie, G. Haddad, 2013, BMC Genomics.

Altered iPSC-derived neurons’ sodium channel properties in subjects with Monge’s disease

G. Perkins, A. Muotri, X. Gu, 2015, Neuroscience.