U. Gether

发表

Correlation between Genetic and Geographic Structure in Europe

Christian Gieger, Jaume Bertranpetit, Michael Krawczak, 2008, Current Biology.

Structure–activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5‐HT transporter

K. Bogeso, U. Gether, M. Larsen, 2016, British journal of pharmacology.

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

Daniel Picot, Brian G. Fox, Lan Guan, 2010, Nature Methods.

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

Harel Weinstein, Thijs Beuming, Irina S Moreira, 2009, Proceedings of the National Academy of Sciences.

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors.

U. Gether, 2000, Endocrine reviews.

Water transport by the human Na+‐coupled glutamate cotransporter expressed in Xenopus oocytes

U. Gether, N. MacAulay, T. Zeuthen, 2001, Journal of Physiology.

G Protein-coupled Receptors

B. Kobilka, U. Gether, 1998, The Journal of Biological Chemistry.

The binding sites for cocaine and dopamine in the dopamine transporter overlap

H. Weinstein, Lei Shi, J. Javitch, 2008, Nature Neuroscience.

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

U. Gether, Jacob Andersen, A. Kristensen, 2011, Pharmacological Reviews.

A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.

D. Tuveson, D. Fearon, J. D. Dal Porto, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis for activation of G-protein-coupled receptors.

Ulrik Gether, S. Rasmussen, U. Gether, 2002, Pharmacology & toxicology.

A dominant-negative variant in the dopamine transporter PDZ-binding motif is linked to parkinsonism and neuropsychiatric disease

T. Werge, A. Galli, A. Newman, 2020 .

Regulation of dopamine transporter function by protein‐protein interactions: new discoveries and methodological challenges

Ulrik Gether, U. Gether, T. N. Jørgensen, 2010, Journal of neurochemistry.

Membrane Localization is Critical for Activation of the PICK1 BAR Domain

Harel Weinstein, Masha Y Niv, Dimitrios Stamou, 2008, Traffic.

Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6*

J. Ballesteros, Lei Shi, G. Liapakis, 2001, The Journal of Biological Chemistry.

[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist.

T. Schwartz, L. Aakerlund, U. Gether, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

U. Gether, H. Bräuner‐Osborne, Stine E. Jacobsen, 2017, Scientific Reports.

Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

U. Gether, C. Loland, Solveig G Schmidt, 2021, Neurochemical research.

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2020, Nature Communications.

Conformational dynamics of the human serotonin transporter during substrate and drug binding

S. Rasmussen, U. Gether, C. Loland, 2019, Nature Communications.

Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter:Sodium Symporter LeuT

M. Cuendet, U. Gether, C. Loland, 2017, bioRxiv.

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

F. H. Larsen, H. Oschkinat, K. Teilum, 2017, eLife.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290*

H. Weinstein, Lei Shi, J. Javitch, 2016, The Journal of Biological Chemistry.

The Serotonin Transporter Undergoes Constitutive Internalization and Is Primarily Sorted to Late Endosomes and Lysosomal Degradation*

U. Gether, T. N. Jørgensen, Jacob Eriksen, 2014, The Journal of Biological Chemistry.

Serotonin-induced down-regulation of cell surface serotonin transporter

U. Gether, T. N. Jørgensen, P. M. Christensen, 2014, Neurochemistry International.

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT

C. Fishwick, A. Johnson, K. Simmons, 2013, Molecular membrane biology.

Generation of an activating Zn2+ switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

T. Litman, U. Gether, C. Loland, 2002, Proceedings of the National Academy of Sciences of the United States of America.

No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

T. Werge, J. Bukh, M. Vinberg, 2010, European Neuropsychopharmacology.

Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

G. Wörtwein, U. Gether, D. Dencker, 2017, Journal of Neuroscience Methods.

Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

U. Gether, A. T. Sørensen, D. Woldbye, 2019, Pharmacological Reviews.

In Vivo Amphetamine Action is Contingent on αCaMKII

T. Sotnikova, R. Gainetdinov, H. Sitte, 2014, Neuropsychopharmacology.

Escitalopram and Neuroendocrine Response in Healthy First-Degree Relatives to Depressed Patients – A Randomized Placebo-Controlled Trial

M. Vinberg, U. Knorr, L. Kessing, 2011, PLoS ONE.

Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals

M. Parent, L. Trudeau, U. Gether, 2020, bioRxiv.

Molecular mechanism of activation and inhibition of 7TM peptide receptors

T. Schwartz, M. Rosenkilde, C. Elling, 1994 .

Chimeric NK1 (substance P)/NK3 (neurokinin B) receptors. Identification of domains determining the binding specificity of tachykinin agonists.

T. Schwartz, U. Gether, T. Johansen, 1993, The Journal of biological chemistry.

The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.

T. Schwartz, C. J. Jensen, U. Gether, 1994, Molecular pharmacology.

Evidence for a common molecular mode of action for chemically distinct nonpeptide antagonists at the neurokinin-1 (substance P) receptor.

T. Schwartz, U. Gether, T. Johansen, 1994, Molecular pharmacology.

The monoamine neurotransmitter transporters: structure, conformational changes and molecular gating.

U. Gether, L. Norregaard, 2001, Current opinion in drug discovery & development.

Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering.

M. L. Karlsen, H. Weinstein, B. Vestergaard, 2015, Structure.

Structure of Dimeric and T etrameric Complexes of the BAR Domain Protein PICK 1 Determined by Small-Angle X-Ray Scattering Graphical

M. L. Karlsen, H. Weinstein, B. Vestergaard, 2015 .

Residues in the Extracellular Loop 4 Are Critical for Maintaining the Conformational Equilibrium of the γ-Aminobutyric Acid Transporter-1*

U. Gether, N. MacAulay, T. Zeuthen, 2003, Journal of Biological Chemistry.

Probing dopamine transporter structure and function by Zn2+-site engineering.

U. Gether, C. Loland, K. Norgaard-Nielsen, 2003, European journal of pharmacology.

Surface Targeting of the Dopamine Transporter Involves Discrete Epitopes in the Distal C Terminus But Does Not Require Canonical PDZ Domain Interactions

J. Javitch, U. Gether, C. Loland, 2004, The Journal of Neuroscience.

Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor.

B. Kobilka, U. Gether, 2002, Methods in enzymology.

Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites.

H Weinstein, J. Ballesteros, H. Weinstein, 2000, Biochemistry.

Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8

H. Sitte, J. Javitch, M. Quick, 2005, Neuropharmacology.

Insights From Endogenous and Engineered Zn2+ Binding Sites in Monoamine Transporters

U. Gether, C. Loland, 2004 .

Evidence for Distinct Sodium-, Dopamine-, and Cocaine-dependent Conformational Changes in Transmembrane Segments 7 and 8 of the Dopamine Transporter*

U. Gether, C. Loland, L. Norregaard, 2003, Journal of Biological Chemistry.

Zn2+ site engineering at the oligomeric interface of the dopamine transporter

J. Javitch, U. Gether, H. Hastrup, 2002, FEBS letters.

Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents.

U. Gether, C. Loland, N. MacAulay, 2001, The Journal of biological chemistry.

The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

M. Verhage, P. Pinheiro, U. Gether, 2014, The Journal of Neuroscience.

G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

G. Wörtwein, U. Gether, D. Dencker, 2019, Neuropharmacology.

The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway

U. Gether, K. Madsen, H. Bräuner‐Osborne, 2017, The Journal of Biological Chemistry.

Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation.

U. Gether, S. Ramamoorthy, Troels Rahbek-Clemmensen, 2015, The Biochemical journal.

G protein‐coupled receptor pharmacology—The next generation

M. Rosenkilde, D. Gloriam, U. Gether, 2020, Basic & clinical pharmacology & toxicology.

A high‐affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

C. Meehan, C. Vaegter, K. Teilum, 2020, EMBO molecular medicine.

Identification of Intra- and Intermolecular Disulfide Bridges in the Multidrug Resistance Transporter ABCG2*

T. Litman, U. Gether, U. Henriksen, 2005, Journal of Biological Chemistry.

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

U. Gether, Tommaso Patriarchi, Lin Tian, 2022, Communications Biology.

Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2

T. Litman, U. Gether, U. Henriksen, 2005, Journal of Cell Science.

Fluorescent Labeling of Purified β2 Adrenergic Receptor

B. Kobilka, U. Gether, Sansan Lin, 1995, The Journal of Biological Chemistry.

Zn2+ modulation of neurotransmitter transporters.

U. Gether, K. Norgaard-Nielsen, Kristine Norgaard-Nielsen, 2006, Handbook of experimental pharmacology.

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons

R. Huganir, U. Gether, K. Madsen, 2013, Proceedings of the National Academy of Sciences.

Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase

T. Schwartz, L. Aakerlund, U. Gether, 1990, FEBS letters.

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

Thorvald F. Andreassen, H. Weinstein, H. Sitte, 2014, The Journal of clinical investigation.

Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine

J. Javitch, A. Galli, U. Gether, 2006, Molecular Pharmacology.

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort

T. Hansen, H. Ullum, T. Werge, 2013, PloS one.

Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF- cytokine response in a Danish Cohort

T. Hansen, H. Ullum, T. Werge, 2013 .

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity

M. Sauer, A. Newman, U. Gether, 2022, bioRxiv.

PreproVIP‐derived peptides in tissue and plasma from patients with VIP‐producing tumours

U. Gether, J. Fahrenkrug, D. RØNNOV‐JENSEN, 1991, European journal of clinical investigation.

Rab2 drives axonal transport of dense core vesicles and lysosomal organelles

O. Kjaerulff, U. Gether, V. K. Lund, 2020, bioRxiv.

Dissociating reward sensitivity and negative urgency effects on impulsivity in the five-choice serial reaction time task

T. Robbins, J. Dalley, Torben Sell, 2022, Brain and neuroscience advances.

Binding epitopes for peptide and non-peptide ligands on the NK1 (substance P) receptor

S. Nakanishi, J. Lowe, T. Schwartz, 1992, Regulatory Peptides.

DimerX Peptide Presentation Technology (continued from cover)

D. Fearon, B. Čatipović, U. Gether, 2001 .

Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression

K. D. Jakobsen, August G. Wang, T. Werge, 2012, Acta Neuropsychiatrica.

Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling

B. Kobilka, K. Wenzel-Seifert, R. Seifert, 1998, The Journal of Biological Chemistry.

A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data

U. Gether, K. Madsen, Freja Herborg, 2022, Nature Communications.

Examination of ligand-induced conformational changes in the beta2 adrenergic receptor.

B. Kobilka, R. Seifert, P. Ghanouni, 1998, Life Science.

The Effect of pH on β2 Adrenoceptor Function

S. Rasmussen, B. Kobilka, R. Seifert, 2000, The Journal of Biological Chemistry.

Tyrosylation and purification of peptides for radioiodination.

T. Schwartz, U. Gether, H. V. Nielsen, 1988, Journal of chromatography.

An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.

H. Weinstein, G. Khelashvili, U. Gether, 2018, Cell reports.

Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor.

B. Kobilka, R. Seifert, P. Ghanouni, 1999, Journal of receptor and signal transduction research.

Examination of ligand-induced conformational changes in the beta 2-adrenergic receptor by fluorescence spectroscopy.

B. Kobilka, U. Gether, B. K. Kobilka, 1998, Advances in pharmacology.

Amphetamine Action at the Cocaine- and Antidepressant-Sensitive Serotonin Transporter Is Modulated by αCaMKII

Therese R. Montgomery, H. Sitte, M. Freissmuth, 2015, The Journal of Neuroscience.

A classifier driven approach to find biomarkers for affective disorders from transcription profiles in blood

H. Ullum, T. Werge, E. Mosekilde, 2016 .

Ligand stabilization of the beta 2 adrenergic receptor: effect of DTT on receptor conformation monitored by circular dichroism and fluorescence spectroscopy.

B. Kobilka, U. Gether, S. Lin, 1996, Biochemistry.

Examining the efficiency of receptor/G‐protein coupling with a cleavable β2‐adrenoceptor–Gsα fusion protein

B. Kobilka, K. Wenzel-Seifert, R. Seifert, 1999 .

Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor.

B. Kobilka, K. Wenzel-Seifert, R. Seifert, 1998, The Journal of biological chemistry.

Stable expression of high affinity NK1 (substance P) and NK2(neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells

T. Schwartz, U. Gether, T. Johansen, 1992, FEBS letters.

Agonists induce conformational changes in transmembrane domains III and VI of the β2 adrenoceptor

H Weinstein, P Ghanouni, J. Ballesteros, 1997, The EMBO journal.

Comparison of peptidyl-glycine α-amidation activity in medullary thyroid carcinoma cells, pheochromocytomas, and serum

T. Schwartz, L. Aakerlund, U. Gether, 1991, Molecular and Cellular Endocrinology.

It takes two—or more—to tango: Revisiting the role of dopamine transporter oligomerization

H. Sitte, U. Gether, 2021, The Journal of biological chemistry.

Structural biology: Antidepressants at work

M. Caron, U. Gether, 2016, Nature.

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.

A. Newman, U. Gether, Vivek Kumar, 2014, ACS medicinal chemistry letters.

Postendocytic Sorting of Constitutively Internalized Dopamine Transporter in Cell Lines and Dopaminergic Neurons*

A. Newman, U. Gether, T. N. Jørgensen, 2010, The Journal of Biological Chemistry.

Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching.

C. Vaegter, U. Gether, S. Ramamoorthy, 2007, Biochemistry.

Purification and fluorescent labeling of the human serotonin transporter.

S. Rasmussen, U. Gether, 2005, Biochemistry.

Engineered Zn Switches in the -Aminobutyric Acid (GABA) Transporter-1 DIFFERENTIAL EFFECTS ON GABA UPTAKE AND CURRENTS*

U. Gether, C. Loland, N. MacAulay, 2001 .

Clinical Practice and Epidemiology in Mental Health Validity of the Diagnosis of a Single Depressive Episode in a Case Register

J. Bukh, M. Vinberg, L. Kessing, 2008 .

Ligand Stabilization of the â 2 Adrenergic Receptor : Effect of DTT on Receptor Conformation Monitored by Circular Dichroism and Fluorescence Spectroscopy †

B. Kobilka, U. Gether, Sansan Lin, 2022 .

Behavioral encoding across timescales by region-specific dopamine dynamics

Jakob K. Dreyer, U. Gether, A. T. Sørensen, 2022, bioRxiv.

Obituary

U. Gether, U. Simonsen, Kim Brøsen, 1902, Basic & clinical pharmacology & toxicology.

Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected].

J. Lowe, T. Schwartz, U. Gether, 1994, The Journal of biological chemistry.

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.

S. Rasmussen, A. Newman, U. Gether, 2005, Journal of medicinal chemistry.

Calmodulin Kinase II Interacts with the Dopamine Transporter C Terminus to Regulate Amphetamine-Induced Reverse Transport

H. Sitte, J. Javitch, R. Colbran, 2006, Neuron.

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.

U. Gether, T. S. Thorsen, K. Madsen, 2012, Biochemistry.

Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter

H. Sitte, Lei Shi, U. Gether, 2016, Nature Communications.

Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

H. Sitte, A. Newman, U. Gether, 2008, Molecular Pharmacology.

Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations.

R Seifert, B. Kobilka, R. Seifert, 1999, Molecular pharmacology.

High-performance liquid chromatography of phenylthiocarbamyl derivatives of amino acids and side-chain derivatized amino acids.

T. Schwartz, U. Gether, H. V. Nielsen, 1987, Journal of chromatography.

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes.

B. Kobilka, U. Gether, U Gether, 1995, The Journal of biological chemistry.

Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6.

P Ghanouni, G. Liapakis, J. Javitch, 1999, Molecular pharmacology.

Novel tripod amphiphiles for membrane protein analysis.

S. Rasmussen, A. Kruse, P. S. Chae, 2013, Chemistry.

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.

S. Rasmussen, A. Kruse, P. S. Chae, 2013, Chemical communications.

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.

A. Abeliovich, A. Newman, U. Gether, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

U. Gether, C. Loland, Solveig G Schmidt, 2021, Neurochemical Research.

Zinc Potentiates an Uncoupled Anion Conductance Associated with the Dopamine Transporter*

H. Sitte, U. Gether, A. Meinild, 2004, Journal of Biological Chemistry.

Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist

S. Nakanishi, J. Lowe, T. Schwartz, 1993, Nature.

Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.

S. Nakanishi, J. Lowe, T. Schwartz, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.

Irina S. Moreira, Harel Weinstein, S. Brøgger Christensen, 2010, Organic & biomolecular chemistry.

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors.

M. Wallace, Heinrich J.G. Matthies, A. Galli, 2019, The Journal of clinical investigation.

Neuropsychiatric disease–associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

Thorvald F. Andreassen, U. Gether, C. Loland, 2018, The Journal of Biological Chemistry.

Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors

J. Sutcliffe, Thorvald F. Andreassen, J. Veenstra-VanderWeele, 2015, EBioMedicine.

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

J. Sutcliffe, E. Cook, Heinrich J.G. Matthies, 2013, Molecular Psychiatry.

Passive water and urea permeability of a human Na+–glutamate cotransporter expressed in Xenopus oocytes

Ulrik Gether, Thomas Zeuthen, Nanna MacAulay, 2002, The Journal of physiology.

Phosphorylation of the Norepinephrine Transporter at Threonine 258 and Serine 259 Is Linked to Protein Kinase C-mediated Transporter Internalization*

U. Gether, S. Ramamoorthy, D. Samuvel, 2006, Journal of Biological Chemistry.

Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

K. L. Martinez, K. Teilum, U. Gether, 2018, eLife.

Efficient amidation of C-peptide deleted NPY precursors by non-endocrine cells is affected by the presence of Lys-Arg at the C-terminus

T. Schwartz, B. Wulff, H. Okamoto, 1993, Molecular and Cellular Endocrinology.

Delineation of an endogenous zinc‐binding site in the human dopamine transporter

E. Nielsen, U. Gether, L. Norregaard, 1998, The EMBO journal.

Syntaxin 1A Interaction with the Dopamine Transporter Promotes Amphetamine-Induced Dopamine Efflux

J. Javitch, R. Colbran, E. Bowton, 2008, Molecular Pharmacology.

System: Mechanisms and Functions Neurotrophin-Mediated Rapid Signaling in the Central Nervous

A. Konnerth, H. Yeh, P. Castillo, 2012 .

Protein Interacting with C Kinase 1 (PICK1) Reduces Reinsertion Rates of Interaction Partners Sorted to Rab11-dependent Slow Recycling Pathway*

U. Gether, T. S. Thorsen, K. Madsen, 2012, The Journal of Biological Chemistry.

Disruption of the PDZ domain–binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

R. Gainetdinov, A. Fink-Jensen, G. Wörtwein, 2021, The Journal of biological chemistry.

Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD

Maximilian G. Parker, T. Robbins, J. Dalley, 2021, Psychopharmacology.

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

U. Gether, Tommaso Patriarchi, Lin Tian, 2021, Communications Biology.

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

P Ghanouni, R Seifert, S. Rasmussen, 2000, The Journal of biological chemistry.

Does bereavement-related first episode depression differ from other kinds of first depressions?

J. Bukh, M. Vinberg, L. Kessing, 2010, Social Psychiatry and Psychiatric Epidemiology.

No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial

M. Vinberg, U. Knorr, L. Kessing, 2015, Acta Neuropsychiatrica.

Differences Between Early and Late Onset Adult Depression

J. Bukh, M. Vinberg, L. Kessing, 2011, Clinical practice and epidemiology in mental health : CP & EMH.

The Scaffold Protein PICK1 as a Target in Chronic Pain

U. Gether, A. T. Sørensen, K. Madsen, 2022, Cells.

Copy number variations in affective disorders and meta-analysis

T. Hansen, K. D. Jakobsen, H. Ullum, 2011, Psychiatric genetics.

Reliability of clinical ICD-10 diagnoses among electroconvulsive therapy patients with chronic affective disorders

T. Hansen, K. D. Jakobsen, T. Werge, 2008 .

Direct-Pathway Spiny Projection Neuron Inhibition Evokes Transient Circuit Imbalance Manifested as Rotational Behavior

U. Gether, Mattias Rickhag, M. Christensen, 2020, Neuroscience.

Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice

U. Gether, Mattias Rickhag, Chiara Ciriachi, 2019, Neuroscience.

Structural Instability of a Constitutively Active G Protein-coupled Receptor

Brian K. Kobilka, Harel Weinstein, Roland Seifert, 1997, The Journal of Biological Chemistry.

Agonist-induced Conformational Changes at the Cytoplasmic Side of Transmembrane Segment 6 in the β2 Adrenergic Receptor Mapped by Site-selective Fluorescent Labeling*

F Guarnieri, J. Ballesteros, F. Guarnieri, 2001, The Journal of Biological Chemistry.

The solute carrier 6 family of transporters

S. Bröer, U. Gether, 2012, British journal of pharmacology.

Neurotransmitter transporters: molecular function of important drug targets.

A. Schousboe, U. Gether, O. Larsson, 2006, Trends in pharmacological sciences.

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1

M. Brasch, Allison Paradise, U. Gether, 2007, The European journal of neuroscience.

A randomized trial of the effect of escitalopram versus placebo on cognitive function in healthy first-degree relatives of patients with depression

A. Gade, M. Vinberg, U. Knorr, 2011, Therapeutic advances in psychopharmacology.

Interaction between genetic polymorphisms and stressful life events in first episode depression.

T. Werge, J. Bukh, M. Vinberg, 2009, Journal of affective disorders.

Molecular Determinants for the Complex Binding Specificity of the PDZ Domain in PICK1*

H. Weinstein, M. Niv, Chiung-wen Chang, 2005, Journal of Biological Chemistry.

Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

T. Werge, A. Galli, A. Newman, 2021, JCI insight.

A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function

U. Gether, T. N. Jørgensen, Ina Ammendrup-Johnsen, 2016, Neurochemistry International.

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Ara M. Abramyan, Lei Shi, A. Mørk, 2020, Nature Communications.

PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance

R. Huganir, B. Holst, U. Gether, 2013, PLoS biology.

Theory of visual attention (TVA) applied to rats performing the 5-choice serial reaction time task: differential effects of dopaminergic and noradrenergic manipulations

T. Robbins, Anders Petersen, S. Vangkilde, 2022, Psychopharmacology.

Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini*

M. Scheinin, A. Newman, U. Gether, 2016, The Journal of Biological Chemistry.

Amphipathic motifs in BAR domains are essential for membrane curvature sensing

U. Gether, Pierre-Yves Bolinger, D. Stamou, 2009, The EMBO journal.

Glycine Transporter Dimers

H. Sitte, A. Nicke, U. Gether, 2008, Journal of Biological Chemistry.

Supplemental Information Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK 1 Determined by Small-Angle X-Ray Scattering

M. L. Karlsen, H. Weinstein, B. Vestergaard, 2022 .

Protein Interacting with C-kinase 1 (PICK1) Binding Promiscuity Relies on Unconventional PSD-95/Discs-Large/ZO-1 Homology (PDZ) Binding Modes for Nonclass II PDZ Ligands*

K. Teilum, Pétur O. Heidarsson, F. Poulsen, 2014, The Journal of Biological Chemistry.

BAR domains, amphipathic helices and membrane‐anchored proteins use the same mechanism to sense membrane curvature

U. Gether, D. Stamou, K. Madsen, 2010, FEBS letters.

How curved membranes recruit amphipathic helices and protein anchoring motifs.

N. Hatzakis, U. Gether, Pierre-Yves Bolinger, 2009, Nature chemical biology.

A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation

U. Gether, P. Plenge, J. Egebjerg, 2009, Neuropharmacology.

Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis

B. Holst, A. Attie, U. Gether, 2022, The Journal of clinical investigation.

Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesis

B. Holst, A. Attie, U. Gether, 2020, bioRxiv.

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins.

S. Rasmussen, A. Kruse, P. S. Chae, 2012, Chemistry.

An unsuspected role for organic cation transporter 3 in the actions of amphetamine

H. Sitte, W. Koek, W. A. Owens, 2018, Neuropsychopharmacology.

Disrupted PDZ-domain binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis and reward motivation

R. Gainetdinov, A. Fink-Jensen, G. Wörtwein, 2021, bioRxiv.

Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor.

B. Kobilka, R. Seifert, U. Gether, 1998, The Journal of biological chemistry.

PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

A. Fink-Jensen, G. Wörtwein, W. A. Owens, 2018, eNeuro.

PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system

O. Kjaerulff, D. Nässel, U. Gether, 2009, The Journal of comparative neurology.

Dopaminergic neurons establish a distinctive axonal arbor with a majority of non‐synaptic terminals

M. Parent, L. Trudeau, U. Gether, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent

J. Holst, A. Fink-Jensen, G. Knudsen, 2020, Neurochemistry International.

GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity.

J. Hecksher-Sørensen, T. Pers, U. Gether, 2023, Cell reports.

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter.

J. Javitch, Brian T DeVree, J. Grimm, 2020, ACS chemical neuroscience.

The Influence of Comorbid Personality Disorder and Neuroticism on Treatment Outcome in First Episode Depression

J. Bukh, M. Vinberg, L. Kessing, 2010, Psychopathology.

Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.

B. Kobilka, R. Seifert, U. Gether, 2001, The Journal of pharmacology and experimental therapeutics.

Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy.

F Ivy Carroll, Ulrik Gether, S. Rasmussen, 2003, European journal of pharmacology.

The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines*

Barbara Zdrazil, Gerhard F. Ecker, Harald H. Sitte, 2010, The Journal of Biological Chemistry.

Identification of Intracellular Residues in the Dopamine Transporter Critical for Regulation of Transporter Conformation and Cocaine Binding*

Jonathan A Javitch, Ulrik Gether, J. Javitch, 2004, Journal of Biological Chemistry.

The Role of Zinc Ions in Reverse Transport Mediated by Monoamine Transporters*

H. Sitte, M. Freissmuth, U. Gether, 2002, The Journal of Biological Chemistry.

Biophysical Characterization of the Cocaine Binding Pocket in the Serotonin Transporter Using a Fluorescent Cocaine Analogue as a Molecular Reporter*

F I Carroll, S. Rasmussen, C. Tate, 2001, The Journal of Biological Chemistry.

Within-Mice Comparison of Microdialysis and Fiber Photometry-Recorded Dopamine Biosensor during Amphetamine Response

U. Gether, G. Sørensen, Joel Wellbourne-Wood, 2023, ACS chemical neuroscience.

An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population

C. Gieger, A. Hofman, A. Uitterlinden, 2009, European Journal of Human Genetics.

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT

Michel A Cuendet, Kasper D Rand, Kamil Gotfryd, 2018, Science Advances.

The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression—A randomised trial

M. Vinberg, U. Knorr, L. Kessing, 2012, Psychiatry Research.

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

U. Gether, F. Vilhardt, T. N. Jørgensen, 2017, Nature Communications.

N-terminal Truncation of the Dopamine Transporter Abolishes Phorbol Ester- and Substance P Receptor-stimulated Phosphorylation without Impairing Transporter Internalization*

J. Javitch, U. Gether, C. Loland, 2003, The Journal of Biological Chemistry.

Conserved HisVI‐17 of the NK‐1 receptor is involved in binding of non‐peptide antagonists but not substance P

T. Schwartz, U. Gether, S. Zoffmann, 1993, FEBS letters.

Tandem facial amphiphiles for membrane protein stabilization.

R. A. Robbins, L. Miercke, R. Stroud, 2010, Journal of the American Chemical Society.

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2020, Nature Communications.

The Second Sodium Site in the Dopamine Transporter Controls Cation Permeation and Is Regulated by Chloride*

Thorvald F. Andreassen, H. Weinstein, Lei Shi, 2014, The Journal of Biological Chemistry.

Membrane-permeable C-terminal Dopamine Transporter Peptides Attenuate Amphetamine-evoked Dopamine Release* ♦

H. Sitte, G. Wörtwein, W. A. Owens, 2013, The Journal of Biological Chemistry.

The binding sites for benztropines and dopamine in the dopamine transporter overlap

H. Weinstein, Lei Shi, A. Newman, 2011, Neuropharmacology.

An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter*

Harel Weinstein, Lei Shi, Jonathan A Javitch, 2008, Journal of Biological Chemistry.

Defining Proximity Relationships in the Tertiary Structure of the Dopamine Transporter

U. Gether, C. Loland, U Gether, 1999, The Journal of Biological Chemistry.

Differential effects of chemogenetic inhibition of dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task

A. Petersen, J. Perrier, U. Gether, 2019, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

A. Petersen, J. Perrier, U. Gether, 2018, eNeuro.

Gender Differences among Patients with a Single Depressive Episode

J. Bukh, M. Vinberg, L. Kessing, 2010, Psychopathology.

Do stressful life events predict medical treatment outcome in first episode of depression?

J. Bukh, M. Vinberg, L. Kessing, 2009, Social Psychiatry and Psychiatric Epidemiology.

Structural basis of organic cation transporter-3 inhibition

T. Werge, H. Sitte, T. Stockner, 2022, bioRxiv.

Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites.

S. Rasmussen, U. Gether, P. Plenge, 2007, European journal of pharmacology.

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter*

H. Weinstein, Lei Shi, A. Newman, 2012, The Journal of Biological Chemistry.

Effect of Chronic Escitalopram versus Placebo on Personality Traits in Healthy First-Degree Relatives of Patients with Depression: A Randomized Trial

M. Vinberg, U. Knorr, L. Kessing, 2012, PloS one.

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

B. Giros, L. Trudeau, U. Gether, 2019, PLoS genetics.

Conformational dynamics of the human serotonin transporter during substrate and drug binding

S. Rasmussen, U. Gether, C. Loland, 2019, Nature Communications.

Brain-derived Neurotrophic Factor (BDNF) Enhances GABA Transport by Modulating the Trafficking of GABA Transporter-1 (GAT-1) from the Plasma Membrane of Rat Cortical Astrocytes*

U. Gether, T. N. Jørgensen, J. Ribeiro, 2011, The Journal of Biological Chemistry.

Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research.

U. Gether, A. T. Sørensen, D. Woldbye, 2017, Basic & clinical pharmacology & toxicology.

Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task

C. Bundesen, T. Habekost, Anders Petersen, 2017, Psychopharmacology.

Visualization of Dopamine Transporter Trafficking in Live Neurons by Use of Fluorescent Cocaine Analogs

S. Rasmussen, C. Vaegter, A. Newman, 2009, The Journal of Neuroscience.

Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression.

J. Bukh, M. Vinberg, L. Kessing, 2010, Journal of affective disorders.

Relative enrichment – a density-based colocalization measure for single-molecule localization microscopy

U. Gether, K. Madsen, Freja Herborg, 2022, bioRxiv.

Preserved dopaminergic homeostasis and dopamine‐related behaviour in hemizygous TH‐Cre mice

U. Gether, Mattias Rickhag, D. Dencker, 2017, The European journal of neuroscience.

A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity

L. Trudeau, U. Gether, G. Sørensen, 2015, The European journal of neuroscience.

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Ara M. Abramyan, Lei Shi, A. Mørk, 2020, Nature Communications.

Initial rewarding effects of cocaine and amphetamine assessed in a day using the single‐exposure place preference protocol

G. Wörtwein, U. Gether, K. L. Jensen, 2018, The European journal of neuroscience.

Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression – a secondary outcome analysis from the randomized AGENDA trial

M. Vinberg, U. Knorr, L. Kessing, 2016, Nordic journal of psychiatry.

Within-animal comparison of microdialysis and fiber photometry in amphetamine-exposed mice

U. Gether, G. Sørensen, Joel Wellbourne-Wood, 2022, bioRxiv.

Conformational basis for the Li+‐induced leak current in the rat γ‐aminobutyric acid (GABA) transporter‐1

U. Gether, N. MacAulay, T. Zeuthen, 2002, The Journal of physiology.

The Environment Shapes the Inner Vestibule of LeuT

Thomas Stockner, Santhosh Kannan Venkatesan, Harald H. Sitte, 2016, PLoS Comput. Biol..

Recruitment of β-arrestin2 to the dopamine D2 receptor: Insights into anti-psychotic and anti-parkinsonian drug receptor signaling

J. Javitch, U. Gether, E. Urizar, 2008, Neuropharmacology.

Amphetamine-induced reverse transport of dopamine does not require cytosolic Ca2.

U. Gether, Freja Herborg, J. F. Støier, 2023, The Journal of biological chemistry.

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.

U. Gether, K. Strømgaard, T. S. Thorsen, 2011, Combinatorial chemistry & high throughput screening.

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters*

George Khelashvili, Jonathan A. Javitch, Harel Weinstein, 2015, The Journal of Biological Chemistry.

A C-terminal PDZ domain binding sequence is required for striatal distribution of the dopamine transporter

G. Wörtwein, E. Füchtbauer, U. Gether, 2013, Nature Communications.

Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding.

T. Schwartz, U. Gether, S. Hjorth, 1994, The Journal of biological chemistry.

Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder

T. Werge, R. Blakely, H. Rasmussen, 2023, medRxiv.

Report Correlation between Genetic and Geographic Structure in Europe

C. Gieger, T. Werge, M. Nothnagel, 2008 .

Report and Geographic Structure in Europe

C. Gieger, T. Werge, M. Nelson, 2022 .

G protein-coupled receptors. II. Mechanism of agonist activation.

B. Kobilka, U. Gether, 1998, The Journal of biological chemistry.

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

U. Gether, Jacob Andersen, A. Kristensen, 2011, Pharmacological Reviews.

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors.

M. Wallace, Heinrich J.G. Matthies, A. Galli, 2019, The Journal of clinical investigation.

Contents of Volume 27

P. Mermelstein, M. Brasch, M. Buffelli, 2007 .