D. Whittington

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Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death

Samuel I. Miller, R. Pfuetzner, E. Gamazon, 2012, Proceedings of the National Academy of Sciences.

A Real-Time Management Model for the Aswan High Dam with Policy Implications

G. Guariso, K. Haynes, D. Whittington, 2010 .

International management of the Nile - stage three?

K. Haynes, D. Whittington, 1981 .

Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir

A. Collier, E. Kharasch, D. Whittington, 2011, Drug Metabolism and Disposition.

Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity

A. Rettie, D. Whittington, E. Kelly, 2016, Drug Metabolism and Disposition.

Simultaneous measurement of etravirine, maraviroc and raltegravir in pigtail macaque plasma, vaginal secretions and vaginal tissue using a LC-MS/MS assay.

Anna K. Blakney, Yonghou Jiang, D. Whittington, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Fatty-acyl chain profiles of cellular phosphoinositides.

B. Hille, D. Whittington, O. Vivas, 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

As in Humans, Pregnancy Increases the Clearance of the Protease Inhibitor Nelfinavir in the Nonhuman Primate Macaca nemestrina

D. Whittington, J. Unadkat, Francisco S Chung, 2009, Journal of Pharmacology and Experimental Therapeutics.

Pregnancy Does Not Increase CYP3A or P-Glycoprotein Activity in the Non-Human Primate, Macaca nemestrina

D. Whittington, J. Unadkat, Francisco S Chung, 2009, Journal of Pharmacology and Experimental Therapeutics.

Influence of Hepatic and Intestinal Cytochrome P4503A Activity on the Acute Disposition and Effects of Oral Transmucosal Fentanyl Citrate

E. Kharasch, D. Whittington, C. Hoffer, 2004, Anesthesiology.

Influence of CYP3A5 Genotype on the Pharmacokinetics and Pharmacodynamics of the Cytochrome P4503A Probes Alfentanil and Midazolam

E. Kharasch, D. Whittington, N. Isoherranen, 2007, Clinical pharmacology and therapeutics.

Fast and sensitive HPLC-MS/MS method for direct quantification of intracellular deoxyribonucleoside triphosphates from tissue and cells.

M. Regnier, D. Whittington, Jason D. Murray, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Role of P‐glycoprotein in the intestinal absorption and clinical effects of morphine

E. Kharasch, D. Whittington, P. Sheffels, 2003, Clinical pharmacology and therapeutics.

Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites, in human and macaque plasma.

D. Mankoff, A. Collier, M. Muzi, 2008, Nuclear medicine and biology.

Mechanism of Efavirenz Influence on Methadone Pharmacokinetics and Pharmacodynamics

D. Whittington, E. Kharasch, S. Campbell, 2012, Clinical pharmacology and therapeutics.

Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport: Insights from Methadone Interactions with Ritonavir/Indinavir

E. Kharasch, D. Whittington, C. Hoffer, 2009, Anesthesiology.

Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.

C. Endres, D. Whittington, C. Tse, 2008, American journal of physiology. Gastrointestinal and liver physiology.

The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone.

E. Kharasch, D. Whittington, C. Hoffer, 2004, British journal of clinical pharmacology.

Influence of Age on the Pharmacokinetics and Pharmacodynamics of Oral Transmucosal Fentanyl Citrate

E. Kharasch, D. Whittington, C. Hoffer, 2004, Anesthesiology.

Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal.

D. Whittington, W. Atkins, L. Balogh, 2010, Archives of biochemistry and biophysics.

Database of Optimized Proteomic Quantitative Methods for Human Drug Disposition‐Related Proteins for Applications in Physiologically Based Pharmacokinetic Modeling

D. Whittington, V. Nautiyal, M. Vrana, 2017, CPT: pharmacometrics & systems pharmacology.

A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma.

N. Sotoodehnia, D. Whittington, R. Lemaitre, 2018, Chemistry and physics of lipids.

Risk of Breast Cancer Associated with Estrogen DNA Adduct Biomarker

R. Chlebowski, T. Rohan, E. Rogan, 2020, Cancer Epidemiology, Biomarkers & Prevention.

Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion

A. Collier, E. Kharasch, D. Whittington, 2012, Drug Metabolism and Disposition.

Quinidine as a Probe for the Role of P‐Glycoprotein in the Intestinal Absorption and Clinical Effects of Fentanyl

E. Kharasch, D. Whittington, C. Hoffer, 2004, Journal of clinical pharmacology.

PhoPQ regulates acidic glycerophospholipid content of the Salmonella Typhimurium outer membrane

Samuel I. Miller, D. Whittington, R. Bishop, 2014, Proceedings of the National Academy of Sciences.

Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis

Kelly K. Lee, M. Guttman, T. Wales, 2016, Journal of The American Society for Mass Spectrometry.

Paradoxical Role of Cytochrome P450 3A in the Bioactivation and Clinical Effects of Levo-α-Acetylmethadol

P. Vicini, E. Kharasch, D. Whittington, 2005 .

ABHD6 selectively controls metabotropic-dependent increases in 2-AG production

M. Bruchas, L. Zweifel, D. Whittington, 2022, bioRxiv.

Role of CYP2B6 in Stereoselective Human Methadone Metabolism

E. Kharasch, D. Whittington, K. Thummel, 2008, Anesthesiology.

New Insights into the Mechanism of Methoxyflurane Nephrotoxicity and Implications for Anesthetic Development (Part 2): Identification of Nephrotoxic Metabolites

H. D. Liggitt, J. Schroeder, E. Kharasch, 2006, Anesthesiology.

New Insights into the Mechanism of Methoxyflurane Nephrotoxicity and Implications for Anesthetic Development (Part 1): Identification of the Nephrotoxic Metabolic Pathway

H. D. Liggitt, J. Schroeder, E. Kharasch, 2006, Anesthesiology.

Determination of morphine and morphine glucuronides in human plasma by 96-well plate solid-phase extraction and liquid chromatography-electrospray ionization mass spectrometry.

E. Kharasch, D. Whittington, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Structure-Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates.

M. Guttman, A. Rettie, D. Whittington, 2019, Chemical research in toxicology.

Glycan targeted polymeric antibiotic prodrugs for alveolar macrophage infections.

T. West, P. Stayton, D. Whittington, 2019, Biomaterials.

Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

A. Collier, E. Kharasch, D. Whittington, 2011, Drug Metabolism and Disposition.

Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity.

E. Kharasch, D. Whittington, C. Hoffer, 2009, Drug and alcohol dependence.

Enantiomeric Metabolic Interactions and Stereoselective Human Methadone Metabolism

E. Kharasch, D. Whittington, R. Totah, 2007, Journal of Pharmacology and Experimental Therapeutics.

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

E. Kharasch, D. Whittington, P. Sheffels, 2004, Clinical pharmacology and therapeutics.

Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A)

E. Kharasch, D. Whittington, C. Hoffer, 2012, Anesthesiology.

Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes

Lauren E. Neidig, K. Cain, S. Kattman, 2021, bioRxiv.

Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry.

E. Kharasch, D. Whittington, P. Sheffels, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol

A. Rettie, D. Whittington, H. Hanenberg, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016.

A. Rettie, D. Whittington, E. Kelly, 2012, Journal of veterinary pharmacology and therapeutics.

Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

A. Collier, E. Kharasch, D. Whittington, 2011, Drug Metabolism And Disposition.

Evaluation of P450 Inhibition and Induction by Artemisinin Antimalarials in Human Liver Microsomes and Primary Human Hepatocytes

D. Goodlett, Yakun Wan, J. Xing, 2012, Drug Metabolism and Disposition.

Evaluation of CYPs inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes

D. Goodlett, Yakun Wan, J. Xing, 2012 .

Sphingosine, a Modulator of Human Translesion DNA Polymerase Activity*

M. Emond, L. Loeb, F. Hanaoka, 2014, The Journal of Biological Chemistry.

DNA Polymerase Activity Sphingosine , a Modulator of Human DNA and Chromosomes :

M. Emond, L. Loeb, F. Hanaoka, 2014 .

The Effects of Pregnancy on Amino Acid Levels and Nitrogen Disposition

M. Hebert, D. Whittington, E. Fay, 2023, Metabolites.

Repeated isolation of an antibiotic-dependent and temperature-sensitive mutant of Pseudomonas aeruginosa from a cystic fibrosis patient.

Alison J. Scott, L. Hoffman, S. Salipante, 2020, The Journal of antimicrobial chemotherapy.

Mechanism of Ritonavir Changes in Methadone Pharmacokinetics and Pharmacodynamics: I. Evidence Against CYP3A Mediation of Methadone Clearance

D. Whittington, E. Kharasch, C. Hoffer, 2008, Clinical pharmacology and therapeutics.

Mechanism of Ritonavir Changes in Methadone Pharmacokinetics and Pharmacodynamics: II. Ritonavir Effects on CYP3A and P‐Glycoprotein Activities

D. Whittington, E. Kharasch, C. Hoffer, 2008, Clinical pharmacology and therapeutics.

Quantitative analysis of chondroitin sulfate disaccharides from human and rodent fixed brain tissue by electrospray ionization-tandem mass spectrometry.

W. Banks, M. Guttman, C. Keene, 2019, Glycobiology.

Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes.

Lauren E. Neidig, K. Cain, S. Kattman, 2021, Stem Cell Reports.

Fibertools: fast and accurate DNA-m6A calling using single-molecule long-read sequencing

William Stafford Noble, Mitchell R. Vollger, A. Stergachis, 2023 .

Planning for capacity expansion: Stochastic process and game-theoretic approaches

Kingsley E. Haynes, K. Haynes, W. Echelberger, 1984 .

Inhibition of P-glycoprotein Activity at the Primate Blood-Brain Barrier Increases the Distribution of Nelfinavir into the Brain but Not into the Cerebrospinal Fluid

D. Whittington, R. Ho, B. D. Anderson, 2007, Drug Metabolism and Disposition.

Inhibition of P-gp activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the CSF

D. Whittington, R. Ho, B. D. Anderson, 2007 .

Sex Hormones in Women With Elevated Breast Cancer Risk Undergoing Weight Loss

Claire J. Han, L. Korde, D. Whittington, 2019, Western journal of nursing research.

Evaluation of P 450 Inhibition and Induction by Artemisinin Antimalarials in Human Liver Microsomes and Primary Human Hepatocytes

D. Goodlett, Yakun Wan, J. Xing, 2012 .

Influence of Age on the Pharmacokinetics and Pharmacodynamics of Oral Transmucosal Fentanyl Citrate

E. Kharasch, D. Whittington, C. Hoffer, 2004, Anesthesiology.