M. Itakura

Shin-ya Watanabe, T. Ohmori, T. Tanahashi, 2012, Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology.

Molecular Cloning of a Human cDNA Encoding a Trifunctional Enzyme of Carbamoyl-Phosphate Synthetase-Aspartate Transcarbamoylase-Dihydroorotase inde NovoPyrimidine Synthesis

K. Yoshimoto, M. Itakura, H. Iwahana, 1996 .

Identification of INS and KCNJ11 gene mutations in type 1B diabetes in Japanese children with onset of diabetes before 5 yr of age

T. Ogata, I. Yokota, M. Itakura, 2013, Pediatric diabetes.

Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese

Y. Nakamura, K. Ikari, Y. Kochi, 2009, Annals of the rheumatic diseases.

Thresholds of Blood Ammonia Reflecting Nucleotide Turnover and Plasma Noradrenaline are Closely Related to Lactate Threshold During Graded Exercise

Hiroaki Tanaka, M. Itakura, A. Kiyonaga, 2012 .

Changes gnosis of Multiple R eview of Cases in Tumors Endocrine Neoplasia in Japan and Analysis

Otsuka, K. Yoshimoto, M. Itakura, 2006 .

p53 gene mutation analysis in porokeratosis and porokeratosis-associated squamous cell carcinoma.

S. Arase, K. Yoshimoto, S. Sasaki, 1997, Journal of dermatological science.

Lack of CD54 expression and mutation of p53 gene relate to the prognosis of childhood Burkitt's lymphoma.

K. Yoshimoto, N. Kiyokawa, J. Fujimoto, 1996, Leukemia & lymphoma.

p53 gene mutations in human skin cancers and precancerous lesions: comparison with immunohistochemical analysis.

Y. Kubo, S. Arase, K. Yoshimoto, 1994, The Journal of investigative dermatology.

ras Mutations in Endocrine Tumors: Mutation Detection by Polymerase Chain Reaction‐Single Strand Conformation Polymorphism

T. Sano, K. Yoshimoto, M. Itakura, 1992, Japanese journal of cancer research : Gann.

p53 Gene Mutations in Hutnan Skin Cancers and Precancerous Lesions: Cotnparison with Immunohistochemical Analysis

Y. Kubo, S. Arase, K. Yoshimoto, 2010 .

Human pituitary adenomas infrequently contain inactivation of retinoblastoma 1 gene and activation of cyclin dependent kinase 4 gene.

T. Sano, S. Yamada, K. Yoshimoto, 2003, Endocrine journal.

Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies.

F. Baas, B. Brais, W. Linssen, 2010, American journal of human genetics.

Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at −420 Appears to Be Increased in Younger-Onset Type 2 Diabetes

M. Kasuga, Y. Tabara, T. Miki, 2007, Diabetes.

Limited synthesis of labile hemoglobin A1 in vivo and in vitro by the preexisting hemoglobin A1 in diabetic subjects.

M. Itakura, K. Yamashita, K. Kunika, 1986, Endocrinologia japonica.

Immunostimulatory versus immunosuppressive roles of IL-10 in IDDM: Analysis with IL-10—Producing transgenic NOD mice

J. Miyazaki, T. Sano, K. Yoshimoto, 1996 .

Inorganic phosphate accelerates hemoglobin A1c synthesis.

M. Itakura, K. Yamashita, K. Kunika, 1989, Life sciences.

Parafibromin tumor suppressor enhances cell growth in the cells expressing SV40 large T antigen

K. Yoshimoto, M. Itakura, Y. Taketani, 2007, Oncogene.

A missense mutant myostatin causes hyperplasia without hypertrophy in the mouse muscle.

K. Moriyama, M. Itakura, H. Ohuchi, 2002, Biochemical and biophysical research communications.

T-cassette ligation: a method for direct sequencing and cloning of PCR-amplified DNA fragments.

K. Yoshimoto, M. Itakura, H. Iwahana, 1994, PCR methods and applications.

Development of pancreatic islets (review).

M. Itakura, T. Yamaoka, 1999, International journal of molecular medicine.

Paradoxical response to parathyroid hormone of renal handling of phosphate in hyperparathyroid rats.

E. Ogata, M. Itakura, N. Kugai, 1982, Endocrinology.

Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells.

M. Itakura, J. Hata, S. Noji, 2002, Biochemical and biophysical research communications.

Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells.

M. Itakura, R. Katashima, H. Iwahana, 1999, European journal of biochemistry.

YKL-40 secreted from adipose tissue inhibits degradation of type I collagen.

M. Wabitsch, N. Ishimaru, Y. Hayashi, 2009, Biochemical and biophysical research communications.

Phosphate Depletion Induced by the Usual Dose of an Antacid

M. Itakura, N. Kugai, N. Kuzuya, 1986 .

Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: predominant localization in pancreatic polypeptide-secreting PP-cells.

M. Itakura, K. Miyawaki, H. Inoue, 2006, Biochemical and biophysical research communications.

Infrequent mutations of p27Kip1 gene and trisomy 12 in a subset of human pituitary adenomas.

T. Sano, S. Yamada, K. Yoshimoto, 1997, The Journal of clinical endocrinology and metabolism.

PKC412 (CGP41251) modulates the proliferation and lipopolysaccharide-induced inflammatory responses of RAW 264.7 macrophages.

M. Itakura, H. Takaku, H. Inoue, 2007, Biochemical and biophysical research communications.

Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction—primer‐introduced restriction analysis

T. Sano, K. Yoshimoto, M. Itakura, 1993, Cancer.

Clonal expansion of CD4+ TCRbetabeta+ T cells in TCR alpha-chain- deficient mice by gut-derived antigens.

H. Kiyono, M. Itakura, R. Katashima, 1999, Journal of immunology.

Somatic Gene Therapy for Diabetes With an Immunological Safety System for Complete Removal of Transplanted Cells

H. Nakauchi, M. Itakura, T. Yamaoka, 1992, Diabetes.

Cystic glucagonoma with loss of heterozygosity on chromosome 11 in multiple endocrine neoplasia type 1

K. Yasuda, K. Yoshimoto, S. Saji, 1997, Clinical endocrinology.

Novel compound heterozygous mutations of the growth hormone-releasing hormone receptor gene in a case of isolated growth hormone deficiency.

M. Itakura, H. Inoue, K. Muroya, 2013, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Proximal 5'-flanking sequence of the human gamma-glutamylcysteine synthetase heavy subunit gene is involved in cisplatin-induced transcriptional up-regulation in a lung cancer cell line SBC-3.

J. Usuda, N. Saijo, K. Nishio, 1997, Biochemical and biophysical research communications.

Identification ofcis-Acting DNA Elements of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

N. Saijo, K. Nishio, H. Arioka, 1997 .

Familial isolated primary hyperparathyroidism with parathyroid carcinomas: clinical and molecular features

K. Yoshimoto, M. Itakura, H. Iwahana, 1998, Clinical endocrinology.

The alpha 2 type IX collagen gene tryptophan polymorphism is not associated with rheumatoid arthritis in the Japanese population

M. Itakura, H. Inoue, S. Nakano, 2006, Clinical Rheumatology.

Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome.

H. Shiota, M. Itakura, H. Inoue, 2005, Investigative ophthalmology & visual science.

Diabetic modifier QTLs in F(2) intercrosses carrying homozygous transgene of TGF-beta.

M. Yoshino, H. Matsushime, M. Itakura, 2008, Mammalian genome : official journal of the International Mammalian Genome Society.

Renal handling of lysozyme in experimental Fanconi syndrome.

M. Itakura, T. Fujita, 1978, The Journal of laboratory and clinical medicine.

Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: Analysis of clinical isolates from herpetic keratitis patients and laboratory strains

H. Shiota, M. Itakura, T. Naito, 1998, Journal of medical virology.

Polyol accumulation versus diabetic retinopathy and nephropathy in transgenic mice expressing human aldose reductase

M. Itakura, T. Yamaoka, Setsuko, 1996 .

Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes.

T. Sano, K. Yoshimoto, H. Kikutani, 1996, The Journal of clinical investigation.

Multiple fluorescence-based PCR-SSCP analysis.

K. Yoshimoto, M. Itakura, H. Iwahana, 1994, BioTechniques.

Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese.

S. Yamada, K. Yoshimoto, M. Itakura, 1998, The Journal of clinical endocrinology and metabolism.

Expression and distribution of Gpr 119 in the pancreatic islets of mice and rats : Predominant localization in pancreatic polypeptide-secreting PP-cells q

M. Itakura, K. Miyawaki, H. Inoue, 2006 .

Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: Roles of epigenetic modifications in transcriptional regulation

Z. Qian, T. Ogata, K. Fujieda, 2011, Molecular and Cellular Endocrinology.

T cell receptor dynamism of mucosal and systemic CD4+ T cells in the course of an immune response to Escherichia coli heat-labile enterotoxin.

J. Mcghee, H. Kiyono, M. Itakura, 2001, The Journal of infectious diseases.

T Cell Receptor Dynamism of Mucosal and Systemic CD 4 + T Cells in the Course of an Immune Response to Escherichia coli Heat-Labile Enterotoxin

J. Mcghee, H. Kiyono, M. Itakura, 2001 .

Galactose-induced albuminuria in transgenic mice expressing human aldose reductase

K. Yoshimoto, J. Fujimoto, M. Itakura, 1995 .

Detection of a new polymorphism of the human prothrombin (F2) gene by combination of PASA and mutated primer-mediated PCR-RFLP

K. Yoshimoto, M. Itakura, H. Iwahana, 1992, Human Genetics.

Highly polymorphic region of the human prothrombin (F2) gene

K. Yoshimoto, M. Itakura, H. Iwahana, 1992, Human Genetics.

Multiple fluorescence-based PCR-SSCP analysis using internal fluorescent labeling of PCR products.

K. Yoshimoto, M. Itakura, T. Iwabuchi, 1996, BioTechniques.

Molecular and genetic analysis of a compound heterozygote for dysprothrombinemia of prothrombin Tokushima and hypoprothrombinemia.

K. Yoshimoto, M. Itakura, H. Iwahana, 1992, American journal of human genetics.

Allele Loss on Chromosome 11 in a Pituitary Tumor from a Patient with Multiple Endocrine Neoplasia Type 1

K. Yoshimoto, M. Itakura, H. Iwahana, 1991, Japanese journal of cancer research : Gann.

TMEM16E (GDD1) Exhibits Protein Instability and Distinct Characteristics in Chloride Channel/Pore Forming Ability

C. Hirono, M. Itakura, H. Inoue, 2014, Journal of cellular physiology.

Assessment of the relationship between serum thyroid hormone levels and peripheral metabolism in patients with anorexia nervosa.

M. Itakura, N. Kuzuya, K. Kawai, 1988, Endocrinologia japonica.

Differential regulation of the human insulin gene transcription by GG1 and GG2 elements with GG- and C1-binding factors.

K. Yoshimoto, M. Itakura, H. Iwahana, 1999, Biochimica et biophysica acta.

Diabetes and tumor formation in transgenic mice expressing Reg I.

K. Yoshimoto, M. Itakura, M. O. Hoque, 2000, Biochemical and biophysical research communications.

Infrequent detectable somatic mutations of the RET and glial cell line-derived neurotrophic factor (GDNF) genes in human pituitary adenomas.

T. Sano, S. Yamada, K. Yoshimoto, 1999, Endocrine journal.

Aminoguanidine decreases urinary albumin and high-molecular-weight proteins in diabetic rats.

M. Itakura, T. Yamaoka, K. Yamashita, 1991, Life sciences.

Molecular characterization of GDD1/TMEM16E, the gene product responsible for autosomal dominant gnathodiaphyseal dysplasia.

M. Itakura, K. Miyawaki, S. Noji, 2007, Biochemical and biophysical research communications.

The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).

J. Inazawa, K. Omura, T. Amagasa, 2004, American journal of human genetics.

Successful treatment of a metastatic hormone-producing adrenal cancer by a combination of mitotane, tegafur and surgical resection.

M. Itakura, N. Kuzuya, Y. Takuwa, 1990, Endocrinologia japonica.

Responsiveness of hypophyseal-adrenocortical axis to repetitive administration of synthetic ovine corticotropin-releasing hormone in patients with isolated adrenocorticotropin deficiency.

M. Ikeda, M. Itakura, Y. Koide, 1986, The Journal of clinical endocrinology and metabolism.

Correction of fructosamine value for serum albumin and globulin concentrations.

M. Itakura, K. Yamashita, K. Kunika, 1991, Diabetes research and clinical practice.

Feedback Inhibition of Amidophosphoribosyltransferase Regulates the Rate of Cell Growth via Purine Nucleotide, DNA, and Protein Syntheses*

S. Hino, M. Itakura, R. Katashima, 2001, The Journal of Biological Chemistry.

Amidophosphoribosyltransferase Limits the Rate of Cell Growth-linked de Novo Purine Biosynthesis in the Presence of Constant Capacity of Salvage Purine Biosynthesis*

K. Yoshimoto, M. Itakura, H. Iwahana, 1997, The Journal of Biological Chemistry.

No association between Rho-associated coiled-coil forming protein serine/threonine kinase1 gene and schizophrenia in the Japanese population.

Hongwei Song, T. Ohmori, T. Tanahashi, 2009, Psychiatric genetics.

Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas.

T. Sano, S. Yamada, K. Yoshimoto, 1998, The Journal of clinical endocrinology and metabolism.

GGAAAT motifs play a major role in transcriptional activity of the human insulin gene in a pancreatic islet beta-cell line MIN6

J. Miyazaki, K. Yoshimoto, M. Itakura, 1996, Diabetologia.

Purification of rat liver amidophosphoribosyltransferase.

M. Itakura, T. Yamaoka, K. Yamashita, 1989, Advances in experimental medicine and biology.

Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism.

T. Sano, K. Yoshimoto, M. Itakura, 1992, Cancer research.

Obvious mRNA and protein expression but absence of mutations of the RET proto-oncogene in parathyroid tumors.

T. Sano, A. Miyauchi, K. Yoshimoto, 1996, European journal of endocrinology.

Absence of mutations at codon 768 of the RET proto-oncogene in sporadic and hereditary pheochromocytomas.

K. Yoshimoto, M. Itakura, H. Iwahana, 1996, Endocrine journal.

Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type.

A. Miyauchi, K. Yoshimoto, M. Itakura, 1995, Endocrine journal.

Familial juvenile hyperuricemic nephropathy: detection of mutations in the uromodulin gene in five Japanese families.

A. Taniguchi, H. Yamanaka, N. Kamatani, 2004, Kidney international.

Molecular cloning and tissue-specific expression of a new member of the regenerating protein family, islet neogenesis-associated protein-related protein.

K. Yoshimoto, M. Itakura, T. Yamaoka, 2000, Biochimica et biophysica acta.

Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL.

Maki Moritani, Mitsuo Itakura, M. Itakura, 2005, Genomics.

Detection of herpes simplex virus DNA in tear fluid of stromal herpetic keratitis patients by nested polymerase chain reaction.

H. Shiota, M. Itakura, E. Kudo, 1996, Japanese Journal of Ophthalmology.

Association of isolated adrenocorticotropin deficiency with a variety of neuro-somatic abnormalities in congenital facial diplegia (Moebius) syndrome.

M. Itakura, N. Kugai, S. Kuzuhara, 1983, Endocrinologia japonica.

Persistent production of hypoxanthine in rat skeletal muscle causes prolonged hyperuricemia after an exhaustive exercise.

S. Hadano, M. Itakura, H. Goto, 1989 .

Increased rate of de novo purine synthesis and its mechanism in regenerating rat liver.

M. Itakura, K. Yamashita, M. Tsuchiya, 1986, The American journal of physiology.

Increased rate of purine biosynthesis in rat liver after bilateral adrenalectomy.

M. Itakura, K. Yamashita, N. Maeda, 1986, The American journal of physiology.

MUTATION OF THE THYMIDINE KINASE GENE IN A GANCICLOVIRRESISTANT STRAIN OF HERPES SIMPLEX VIRUS TYPE 1 (HSV-1) DETECTED BY PCR-SSCP AND PCR-DIRECT SEQUENCIN G

H. Shiota, M. Itakura, E. Kudo, 1996 .

High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR–SSOP–Luminex method in the Japanese population

H. Inoko, M. Satake, M. Itakura, 2005, Immunogenetics.

Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas

Z. Qian, T. Sano, S. Asa, 2009, Modern Pathology.

Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population.

C. Scafe, M. Itakura, H. Inoue, 2005, Arthritis and rheumatism.

TGFBR2 gene expression and genetic association with schizophrenia.

Masatoshi Takeda, Hiroshi Kunugi, Shu-ichi Ueno, 2008, Journal of psychiatric research.

Identification of protease serine S1 family member 53 as a mitochondrial protein in murine islet beta cells

K. Yoshimoto, N. Harada, M. Itakura, 2021, Islets.

Diabetes and pancreatic tumours in transgenic mice expressing Pa × 6

K. Yoshimoto, M. Itakura, T. Yamada, 2000, Diabetologia.

Role of p 53 Mutations in Endocrine Tumorigenesis : Mutation Detection by Polymerase Chain Reaction-Single Strand Conformation Polymorphism 1

T. Sano, K. Yoshimoto, M. Itakura, 2006 .

p53 gene mutation in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder tumors and N-methyl-N-nitrosourea-induced colon tumors of rats.

K. Yoshimoto, M. Itakura, H. Iwahana, 1997, Cancer letters.

Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants.

M. Itakura, T. Yamada, S. Noji, 1998, The Journal of clinical investigation.

Trifunctional Enzyme of Pyrimidine Metabolism

M. Itakura, H. Iwahana, 2002 .

Relatively good prognosis of multiple endocrine neoplasia type 2B in Japanese: review of cases in Japan and analysis of genetic changes in tumors.

K. Yoshimoto, M. Itakura, H. Iwahana, 1993, Endocrine journal.

GH‐secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23–24

T. Sano, S. Yamada, K. Yoshimoto, 2003, Clinical endocrinology.

Molecular cloning and expression analysis of a putative nuclear protein, SR-25.

K. Yoshimoto, M. Itakura, M. Tanaka, 2000, Biochemical and biophysical research communications.

Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1.

J. Miyazaki, T. Sano, K. Yoshimoto, 1998, The Journal of clinical investigation.

Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice

M. Itakura, H. Inoue, K. Kunika, 2006, Mammalian Genome.

Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas.

T. Sano, S. Yamada, K. Yoshimoto, 1997, European journal of endocrinology.

Identification of specific sequence motifs in the upstream region of 242 human miRNA genes

Kenji Kita, Hiroshi Inoue, Shuichi Shinohara, 2007, Comput. Biol. Chem..

Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature.

T. Ogata, K. Fujieda, M. Itakura, 2011, The Journal of clinical endocrinology and metabolism.

SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population

H. Shiota, T. Yoshikawa, T. Tanahashi, 2007, Journal of Human Genetics.

Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population.

Yusuke Nakamura, Takahiko Horiuchi, Kazuhiko Yamamoto, 2008, Arthritis and rheumatism.

Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies

T. Tanahashi, M. Itakura, H. Inoue, 2008, Journal of Human Genetics.

Two New Nonsense Mutations in Type Ia Antithrombin III Deficiency at Leu 140 and Arg 197

K. Yoshimoto, M. Itakura, H. Iwahana, 1992, Thrombosis and Haemostasis.

Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects

T. Ohmori, T. Tanahashi, N. Nakamura, 2008, Journal of Human Genetics.

Identification of cis‐element regulating expression of the mouse Fgf10 gene during inner ear development

K. Moriyama, M. Itakura, H. Ohuchi, 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

An unusual kindred of the multiple endocrine neoplasia type 1 (MEN1) in Japanese.

K. Yoshimoto, M. Itakura, M. Taniyama, 2000, The Journal of clinical endocrinology and metabolism.

HLA-DR shared epitope in familial cases of Japanese rheumatoid arthritis.

M. Itakura, M. Goto, F. Takeuchi, 2000, Clinical and experimental rheumatology.

Detection of different quasispecies of hepatitis C virus core region in cancerous and noncancerous lesions.

K. Yoshimoto, S. Tashiro, M. Itakura, 1996, Biochemical and biophysical research communications.

Identification of cis-elements regulating expression of Fgf10 during limb development.

S. Kato, M. Itakura, H. Ohuchi, 2002, The International journal of developmental biology.

Inactivation of the tumor suppressor gene on 11q13 in brothers with familial acrogigantism without multiple endocrine neoplasia type 1.

T. Sano, K. Yoshimoto, M. Itakura, 1997, The Journal of clinical endocrinology and metabolism.

No association between the NDE1 gene and schizophrenia in the Japanese population

K. Ohi, R. Hashimoto, M. Takeda, 2008, Schizophrenia Research.

Genetic association between the PRKCH gene encoding protein kinase Ceta isozyme and rheumatoid arthritis in the Japanese population.

N. Kamatani, C. Scafe, M. Itakura, 2007, Arthritis and rheumatism.

In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4

S. Hino, M. Itakura, T. Yamada, 2004, Diabetologia.

Differentiation phenotypes of pancreatic islet β- and α-cells are closely related with homeotic genes and a group of differentially expressed genes

K. Yoshimoto, N. Harada, M. Itakura, 2004 .

Mode of inheritance of HLA-DRB1 shared epitope in Japanese familial rheumatoid arthritis.

M. Itakura, M. Goto, F. Takeuchi, 2002, Clinical and experimental rheumatology.

Association between PNPO and schizophrenia in the Japanese population

Hongwei Song, T. Ohmori, T. Tanahashi, 2007, Schizophrenia Research.

Autosomal Dominant Gnathodiaphyseal Dysplasia Maps to Chromosome 11p14.3‐15.1

K. Omura, M. Itakura, M. Nagayama, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population

E. Hattori, M. Ikeda, T. Toyota, 2013, Molecular Psychiatry.

Genetic association of single nucleotide polymorphisms in endonuclease G-like 1 gene with type 2 diabetes in a Japanese population

H. Shiota, T. Yoshikawa, T. Tanahashi, 2007, Diabetologia.

Association study on chromosome 20q11.21-13.13 locus and its contribution to type 2 diabetes susceptibility in Japanese

Naoto Nakamura, Eiichiro Ichiishi, Yuka Yamaguchi, 2006, Human Genetics.

Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population

H. Shiota, T. Yoshikawa, T. Tanahashi, 2008, BMC Medical Genetics.

Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping.

Naoyuki Kamatani, Yuka Yamaguchi, Maki Moritani, 2006, Genomics.

Physiologic concentrations of inorganic phosphate accelerate fructosamine synthesis.

M. Itakura, K. Yamashita, K. Kunika, 1992, Diabetes Research and Clinical Practice.

Identification of a novel mutation in the exon 2 splice donor site of the POU1F1/PIT‐1 gene in Japanese identical twins with mild combined pituitary hormone deficiency

T. Ogata, K. Fujieda, M. Itakura, 2012, Clinical endocrinology.

Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis.

K. Yoshimoto, M. Itakura, M. Tanaka, 1995, Cancer letters.

Determination of the number and relative molecular mass of subunits in an oligomeric protein by two-dimensional electrophoresis. Application to the subunit structure analysis of rat liver amidophosphoribosyltransferase.

M. Itakura, T. Yamaoka, K. Yamashita, 1993, Journal of chromatography.

Association of elastin glycation and calcium deposit in diabetic rat aorta.

M. Itakura, M. Yamazaki, K. Yamashita, 1993, Diabetes research and clinical practice.

The rate of cell growth is regulated by purine biosynthesis via ATP production and G(1) to S phase transition.

K. Yoshimoto, M. Itakura, Y. Hayashi, 2000, Journal of biochemistry.

Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes.

K. Yoshimoto, M. Itakura, Y. Takahashi, 1995, Biochimica et biophysica acta.

Gene Cloning and Function Analysis of Replication Factor C from Thermococcus kodakaraensis KOD1

M. Esaka, T. Imanaka, M. Itakura, 2003, Bioscience, biotechnology, and biochemistry.

No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population

H. Shiota, T. Yoshikawa, T. Tanahashi, 2006, Journal of Human Genetics.

Hypoplasia of endocrine and exocrine pancreas in homozygous transgenic TGF-β1

M. Itakura, T. Yamaoka, M. Moritani, 2005, Molecular and Cellular Endocrinology.

Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA

J. Fujimoto, M. Itakura, T. Yamada, 1995, Diabetologia.

Molecular cloning and characterization of the murine gnathodiaphyseal dysplasia gene GDD1.

M. Itakura, H. Inoue, N. Kamata, 2005, Biochemical and biophysical research communications.

[A case of primary hypouricosuric gout associated with mental retardation, self-mutilation and salt dependent hypertension (author's transl)].

E. Ogata, M. Itakura, N. Kugai, 1980, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.

Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population.

Hongwei Song, M. Tomotake, T. Ohmori, 2008, Journal of psychiatric research.

Hereditary adrenocortical unresponsiveness to adrenocorticotropin with a postreceptor defect.

T. Kudo, M. Itakura, T. Yamaoka, 1992, The Journal of clinical endocrinology and metabolism.

Differentiation phenotypes of pancreatic islet beta- and alpha-cells are closely related with homeotic genes and a group of differentially expressed genes.

K. Yoshimoto, N. Harada, M. Itakura, 2004, Gene.

Gene Cloning and Polymerase Chain Reaction with Proliferating Cell Nuclear Antigen from Thermococcus kodakaraensis KOD1

M. Esaka, T. Imanaka, M. Itakura, 2002, Bioscience, biotechnology, and biochemistry.

Association Study Between the Pericentrin (PCNT) Gene and Schizophrenia

K. Ohi, R. Hashimoto, M. Takeda, 2010, NeuroMolecular Medicine.

Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population

T. Asada, H. Kunugi, M. Tomotake, 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Molecular cloning of human amidophosphoribosyltransferase.

K. Yoshimoto, M. Itakura, E. Holmes, 1993, Biochemical and biophysical research communications.

In vivo inhibition of the rate of de novo purine synthesis in rat liver by glucagon.

M. Itakura, K. Yamashita, M. Tsuchiya, 1986, Metabolism: clinical and experimental.

Paradoxical effects of glucagon on de novo purine synthesis in rat liver: in vitro phosphorylation of amidophosphoribosyltransferase.

M. Itakura, T. Yamaoka, K. Yamashita, 1989, Advances in experimental medicine and biology.

Glucagon infusion increases rate of purine synthesis de novo in rat liver.

M. Itakura, K. Yamashita, M. Tsuchiya, 1987, The American journal of physiology.

Controllable expression of an E. coli amidophosphoribosyltransferase (ATase) gene in ATase-deficient mammalian fibroblasts--a basic model for gene therapy.

M. Itakura, H. Zalkin, E. Holmes, 1989 .

Transgenic expression of a mutated cyclin-dependent kinase 4 (CDK4/R24C) in pancreatic beta-cells prevents progression of diabetes in db/db mice.

T. Tanahashi, M. Itakura, K. Miyawaki, 2008, Diabetes research and clinical practice.

Apoptosis and remodelling of beta cells by paracrine interferon-γ without insulitis in transgenic mice

K. Yoshimoto, M. Itakura, T. Yamada, 1999, Diabetologia.

Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation.

M. Itakura, H. Inoue, M. Moritani, 2012, Genes & genetic systems.

Effect of polymer matrix and glycerol on rapid single‐strand conformation polymorphism analysis by capillary and microchip electrophoresis for detection of mutations in K‐ras gene

Lihua Zhang, Yoshinobu Baba, Mitsuo Itakura, 2005, Electrophoresis.

Loss of ganciclovir sensitivity by exclusion of thymidine kinase gene from transplanted proinsulin-producing fibroblasts as a gene therapy model for diabetes.

H. Nakauchi, K. Yoshimoto, M. Itakura, 1996, Gene therapy.

Clonal Expansion of CD4+ TCRββ+ T Cells in TCR α-Chain- Deficient Mice by Gut-Derived Antigens

H. Kiyono, M. Itakura, R. Katashima, 1999, The Journal of Immunology.

Diabetic modifier QTLs in F2 intercrosses carrying homozygous transgene of TGF-β

M. Yoshino, H. Matsushime, M. Itakura, 2007, Mammalian Genome.

Molecular cloning of a cDNA encoding human ribosomal protein L39.

K. Yoshimoto, M. Itakura, M. Tanaka, 1996, Biochimica et biophysica acta.

Diabetic modifier QTL, Dbm4, affecting elevated fasting blood glucose concentrations in congenic mice.

M. Itakura, H. Inoue, M. Moritani, 2012, Genes & genetic systems.

Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.

K. Yoshimoto, M. Itakura, Y. Takahashi, 1996, Biochemical and biophysical research communications.

Multidimensional genome scans identify the combinations of genetic loci linked to diabetes-related phenotypes in mice.

M. Itakura, M. Moritani, H. Yaguchi, 2006, Human molecular genetics.

Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese population.

T. Ohmori, T. Tanahashi, M. Itakura, 2009, Journal of psychiatry & neuroscience : JPN.

Multiple Fluorescence-Based PCR-SSCP Analysis with Primer-, Post-, and Internal-Labeling.

M. Itakura, H. Iwahana, 1998, Methods in molecular medicine.

Interaction between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in age at onset and clinical symptoms in schizophrenia

T. Ohmori, M. Itakura, S. Sumitani, 2007, Journal of Neural Transmission.

Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia

R. Hashimoto, M. Takeda, H. Kunugi, 2007, Neuroscience Letters.

Altered cellular immunity in transgenic mice with T cell-specific expression of human D4-guanine diphosphate-dissociation inhibitor (D4-GDI).

Kohji Yamada, M. Itakura, J. Hata, 2008, International immunology.

Identification and functional analysis of novel human growth hormone–releasing hormone receptor (GHRHR) gene mutations in Japanese subjects with short stature

T. Ogata, K. Fujieda, M. Itakura, 2011, Clinical endocrinology.

Effect of +36T > C in intron 1 on the glutamine: fructose-6-phosphate amidotransferase 1 gene and its contribution to type 2 diabetes in different populations

T. Yoshikawa, T. Tanahashi, N. Nakamura, 2006, Journal of Human Genetics.

Meta-analysis of association studies between DISC1 missense variants and schizophrenia in the Japanese population

K. Ohi, M. Takeda, I. Imoto, 2012, Schizophrenia Research.

[Metabolism of purine nucleotides and the production of uric acid].

M. Itakura, T. Yamaoka, 1996, Nihon rinsho. Japanese journal of clinical medicine.

Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes.

T. Yoshikawa, T. Tanahashi, N. Nakamura, 2008, Molecular genetics and metabolism.

Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4.

M. Itakura, T. Matsushita, T. Yamaoka, 1998, Biochemical and biophysical research communications.

The effect of non-enzymatic glycation on recombinant human aldose reductase.

M. Itakura, T. Yamaoka, A. Oda, 1995, Diabetes research and clinical practice.

Detection of a single base substitution of the gene for prothrombin Tokushima. The application of PCR-SSCP for the genetic and molecular analysis of dysprothrombinemia.

K. Yoshimoto, M. Itakura, H. Iwahana, 1992, International journal of hematology.

Diabetes mellitus in a Japanese girl with HDR syndrome and GATA3 mutation.

Maki Fukami, Tsutomu Ogata, Mitsuo Itakura, 2010, Endocrine journal.

[Inherited disorders of uric acid metabolism--classification, enzymatic- and DNA-diagnosis].

M. Itakura, H. Iwahana, 1996, Nihon rinsho. Japanese journal of clinical medicine.

Molecular cloning of a group of mouse pancreatic islet beta-cell-related genes by random cDNA sequencing

K. Yoshimoto, M. Itakura, Y. Takahashi, 1995, Diabetologia.

Damage of charge-dependent renal tubular reabsorption causes diabetic microproteinuria.

M. Itakura, T. Yamaoka, K. Kunika, 1997, Diabetes research and clinical practice.

Diabetic damage of selective renal reabsorption assessed by albumin negative charge.

M. Itakura, T. Yamaoka, K. Kunika, 1996, Diabetes research and clinical practice.

Germ-Line Mutations In MEN1 Patients —Authors’ Response

K. Yoshimoto, M. Itakura, C. Tanaka, 1998 .

Expression of somatostatin receptor subtypes and growth inhibition in human exocrine pancreatic cancers.

T. Kikutsuji, S. Tashiro, M. Itakura, 2000, Journal of hepato-biliary-pancreatic surgery.

Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population.

Hongwei Song, M. Tomotake, T. Ohmori, 2008, Journal of psychiatric research.

Central role for aldose reductase pathway in myocardial ischemic injury

S. Homma, Hui Liao, R. Ramasamy, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Development of an automated SNP analysis method using a paramagnetic beads handling robot

M. Machida, H. Hagiwara, M. Yohda, 2007, Biotechnology and bioengineering.

Increased de novo purine synthesis by insulin through selective enzyme induction in primary cultured rat hepatocytes.

M. Itakura, K. Yamashita, H. Yoshikawa, 1990, The American journal of physiology.

Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome.

H. Shiota, M. Itakura, H. Inoue, 2005, Investigative ophthalmology & visual science.

Multiple fluorescence-based PCR-SSCP analysis with postlabeling.

K. Yoshimoto, M. Itakura, R. Katashima, 1995, PCR methods and applications.