B. K. Park

发表

Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene.

M. Pirmohamed, N. Kitteringham, C. Davis, 1996, The Journal of pharmacology and experimental therapeutics.

Fortnightly review: Adverse drug reactions

Munir Pirmohamed, Alasdair Breckenridge, M. Pirmohamed, 1998 .

Parsing interindividual drug variability: an emerging role for systems pharmacology

M. Pirmohamed, B. K. Park, R. Turner, 2015, Wiley interdisciplinary reviews. Systems biology and medicine.

Drug-protein conjugates--XVI. Studies of sorbinil metabolism: formation of 2-hydroxysorbinil and unstable protein conjugates.

B. K. Park, J. Maggs, 1988, Biochemical pharmacology.

Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.

N. Kitteringham, B. K. Park, R. Jenkins, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A method for the rapid depletion of albumin and immunoglobulin from human plasma

M. Pirmohamed, S. Pennington, N. Kitteringham, 2004, Proteomics.

Challenges and approaches for the development of safer immunomodulatory biologics

M. Pirmohamed, S. Holgate, R. Weaver, 2013, Nature Reviews Drug Discovery.

Physiological, pharmacological and toxicological considerations of drug‐induced structural cardiac injury

M. Pirmohamed, P. Clements, A. Norris, 2015, British journal of pharmacology.

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

M. Ingelman-Sundberg, V. Lauschke, N. Kitteringham, 2016, Scientific Reports.

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

M. Daly, D. Goldstein, M. Nelson, 2009, Nature Genetics.

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

Michael R. Johnson, P. Deloukas, K. Shianna, 2011, The New England journal of medicine.

HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors.

B. K. Park, D. Naisbitt, G. Dear, 2018, Chemical research in toxicology.

The effect of enzyme induction on diazepam metabolism in man.

B. K. Park, Ee Ohnhaus, Jp Colombo, 1979 .

Role of drug disposition in drug hypersensitivity: a chemical, molecular, and clinical perspective.

M Pirmohamed, M. Pirmohamed, N. Kitteringham, 1998, Chemical research in toxicology.

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2007, The Journal of allergy and clinical immunology.

Sulfamethoxazole and Its Metabolite Nitroso Sulfamethoxazole Stimulate Dendritic Cell Costimulatory Signaling1

Charlotte A. Ashby, M. Pirmohamed, M. Rieder, 2007, The Journal of Immunology.

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1.

B. K. Park, C. Goldring, D. Naisbitt, 2009, Toxicology and applied pharmacology.

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

J. Timmer, M. Schilling, Daniel Kaschek, 2018, npj Systems Biology and Applications.

Mechanisms of hypertransaminemia

M. Pirmohamed, B. K. Park, B. Park, 1996 .

Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development

Chris S. Pridgeon, R. Pieters, M. Ingelman-Sundberg, 2017 .

FORMATION AND PROTEIN BINDING OF THE ACYL GLUCURONIDE OF A LEUKOTRIENE B4 ANTAGONIST (SB-209247): RELATION TO SPECIES DIFFERENCES IN HEPATOTOXICITY

B. K. Park, J. Maggs, J. Kenny, 2005, Drug Metabolism and Disposition.

Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress

B. K. Park, F. Mutter, I. Copple, 2015, Biochemical Society transactions.

Circulating microRNAs as potential markers of human drug‐induced liver injury

Jonathan Moggs, D. Webb, J. Dear, 2011, Hepatology.

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.

Mitchell R. McGill, Dominic P. Williams, J. Dear, 2012, Journal of hepatology.

Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation.

B. K. Park, J. Maggs, B K Park, 2000, Chemico-biological interactions.

An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes.

B. K. Park, S. Madden, T. Woolf, 1993, Biochemical pharmacology.

Tacrine Transaminitis: Potential Mechanisms

B. K. Park, S. Madden, T. Woolf, 1994 .

Glutathione S-transferase mu genotype (GSTM1*0) in Alzheimer's patients with tacrine transaminitis.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1995, British journal of clinical pharmacology.

TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole.

Clive E. Bowman, W. Thomson, M. Pirmohamed, 2009, Pharmacogenomics.

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies

Neal C Burton, Julie Holder, Neal C. Burton, 2017, npj Regenerative Medicine.

Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies

M. Pirmohamed, P. Dargan, J. Dear, 2017, The lancet. Gastroenterology & hepatology.

Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen‐Induced Liver Injury

J. Dear, J. Bonventre, B. K. Park, 2015, Hepatology.

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

A. Odermatt, D. Kratschmar, A. Lister, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

University of Dundee Chemical tuning enhances both potency toward Nrf 2 and in vitro therapeutic index of triterpenoids

A. Odermatt, D. Kratschmar, A. Lister, 2014 .

The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system

J. Hayes, N. Kitteringham, B. K. Park, 2008, Hepatology.

CDDO-Imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1.

M. Sporn, A. Lister, B. K. Park, 2020, Journal of medicinal chemistry.

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Ursula Klingmüller, Bob van de Water, K. G. Jensen, 2019, Nature Reviews Drug Discovery.

14. MIST AND THE FUTURE

B. K. Park, Dennis A. Smith, B. Park, 2016 .

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway*

A. Lister, N. Kitteringham, B. K. Park, 2010, The Journal of Biological Chemistry.

The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.

N. Kitteringham, B. K. Park, C. Goldring, 2010, Handbook of experimental pharmacology.

Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice

Dominic P. Williams, K. Itoh, Masayuki Yamamoto, 2004, Hepatology.

The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.

N. Kitteringham, B. K. Park, C. Goldring, 2008, Toxicology.

Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.

M. Pirmohamed, W. Rapeport, B. K. Park, 2001, Chemical research in toxicology.

Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration

Yongxiang Fang, S. Forbes, R. Aird, 2021, Hepatology.

PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals

P. Taupin, D. Walker, B. K. Park, 2009 .

Unique properties of conducting polymers of non-degenerated structures poly(3-alkylthiophene) and poly(9-alkylfluorene) mixed with polyacetylene derivatives poly(o-trimethylsilylphenylacetylene)

Tsuyoshi Kawai, Kenji Yoshimoto, Katsumi Yoshino, 1994 .

α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro

B. K. Park, J. Maggs, D. Boocock, 1999 .

British Journal of Clinical Pharmacology

B. Lipworth, P. Waller, G. Tucker, 2013 .

Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.

B. K. Park, P. O’Neill, J. Maggs, 2013, Organic & biomolecular chemistry.

Prediction of metabolic drug interactions involving beta-adrenoceptor blocking drugs.

B. K. Park, 1984, British journal of clinical pharmacology.

Assessment of the drug metabolism capacity of the liver.

B. K. Park, B. Park, 1982, British journal of clinical pharmacology.

Polymorphisms in the TNF‐α and TNF‐receptor genes in patients with coronary artery disease

M. Pirmohamed, B. K. Park, R. Allen, 2001 .

Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine.

B. K. Park, P. O’Neill, J. Maggs, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Activation of Human Dendritic Cells by p-Phenylenediamine

K. L. Mathews, D. Basketter, B. K. Park, 2007, Journal of Pharmacology and Experimental Therapeutics.

Effect of sodium valproate on carbamazepine disposition and psychomotor profile in man.

B. K. Park, G. Macphee, M. Brodie, 1988, British journal of clinical pharmacology.

Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study

P. Ghaneh, G. Poston, N. Kitteringham, 2013, Cancer Chemotherapy and Pharmacology.

Detection of drug bioactivation in vivo: mechanism of nevirapine-albumin conjugate formation in patients.

B. K. Park, D. Naisbitt, R. Jenkins, 2013, Chemical research in toxicology.

MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans

J. Dear, B. K. Park, C. Goldring, 2014, Expert review of clinical pharmacology.

Clinical Implications of Enzyme Induction and Enzyme Inhibition

A. Breckenridge, B. K. Park, B. Park, 1981, Clinical pharmacokinetics.

The effect of fluorine substitution on the hepatotoxicity and metabolism of paracetamol in the mouse.

B. K. Park, D. Kelly, S. Barnard, 1993, Biochemical pharmacology.

The toxicity of amodiaquine and its principal metabolites towards mononuclear leucocytes and granulocyte/monocyte colony forming units.

A. Breckenridge, B. K. Park, J. Maggs, 1990, British journal of clinical pharmacology.

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells

Amy E. Chadwick, R. Weaver, B. K. Park, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.

Dominic P. Williams, M. Pirmohamed, B. K. Park, 1997, The Journal of pharmacology and experimental therapeutics.

Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s).

B. K. Park, J. Maggs, S. Madden, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Keratin‐18 and microRNA‐122 complement alanine aminotransferase as novel safety biomarkers for drug‐induced liver injury in two human cohorts

P. Watkins, C. Mattsson, B. Ekblom, 2014, Liver international : official journal of the International Association for the Study of the Liver.

Immune pathomechanism of drug hypersensitivity reactions.

B. K. Park, D. Naisbitt, W. Pichler, 2011, The Journal of allergy and clinical immunology.

Immunological principles of T-cell-mediated adverse drug reactions in skin

M. Pirmohamed, B. K. Park, D. Naisbitt, 2007, Expert opinion on drug safety.

Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.

M. Pirmohamed, D. Chadwick, M. Britschgi, 2003, Molecular pharmacology.

Characterization of Sulfamethoxazole and Sulfamethoxazole Metabolite-Specific T-Cell Responses in Animals and Humans

M. Pirmohamed, B. K. Park, D. Naisbitt, 2003, Journal of Pharmacology and Experimental Therapeutics.

Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism

B. K. Park, D. Naisbitt, W. Pichler, 2010, The Journal of Immunology.

Immune Cell Formation of a Functional Antigen through Costimulatory Signaling: Evidence for Drug Antigenicity, Immunogenicity, and

B. K. Park, D. Naisbitt, W. Pichler, 2010 .

Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients

B. K. Park, D. Naisbitt, R. Jenkins, 2017, The Journal of Immunology.

Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients.

B. K. Park, D. Naisbitt, R. Jenkins, 2016, Chemical research in toxicology.

The importance of hapten–protein complex formation in the development of drug allergy

B. K. Park, D. Naisbitt, L. Faulkner, 2014, Current opinion in allergy and clinical immunology.

Characterisation of flucloxacillin and 5‐hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo

M. Pirmohamed, N. Kitteringham, B. K. Park, 2009, Proteomics. Clinical applications.

“Danger” Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells

B. K. Park, D. Naisbitt, S. Lavergne, 2009, Journal of Pharmacology and Experimental Therapeutics.

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011, Journal of Pharmacology and Experimental Therapeutics.

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011, The Journal of Immunology.

Urinary excretion of 6β-hydroxycortisol and the time course measurement of enzyme induction in man

A. Breckenridge, B. K. Park, E. Ohnhaus, 2004, European Journal of Clinical Pharmacology.

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity.

M. Pirmohamed, B. K. Park, A. Alfirevic, 2000, Pharmacogenetics.

Co-precipitation of DEAE-dextran coated SPIONs: how synthesis conditions affect particle properties, stem cell labelling and MR contrast.

Harish Poptani, B. K. Park, D. Adams, 2016, Contrast media & molecular imaging.

Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop.

David J. Williams, Robert J. Thomas, Amit Chandra, 2018, Regenerative medicine.

Safety assessment of peroxide antimalarials: clinical and chemical perspectives.

M. Pirmohamed, B. K. Park, P. O’Neill, 1998, British journal of clinical pharmacology.

Efficient regioselective a-ring functionalization of oestrogens

B. K. Park, P. C. Page, F. Hussain, 1990 .

The metabolism of 16-fluoroestradiols in vivo: Chemical strategies for restricting the oxidative biotransformations of an estrogen-receptor imaging agent

B. K. Park, J. Maggs, T. L. Gilchrist, 1997, Steroids.

HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.

M. Pirmohamed, D. Chadwick, P. Williamson, 2006, Pharmacogenomics.

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.

M. Pirmohamed, D. Grant, B. Burchell, 1995, Biochemical pharmacology.

Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.

B. K. Park, P. Stocks, S. Ward, 2002, Journal of medicinal chemistry.

Where are we now with paracetamol?

J. Dear, B. K. Park, D. Antoine, 2015, BMJ : British Medical Journal.

Cortisol metabolism by human liver in vitro—I. Metabolite identification and inter-individual variability

B. K. Park, D. Back, J. Maggs, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

Enzyme induction by phenobarbitone and vitamin K1 disposition in man.

G. Kaatz, B. K. Park, E. Ohnhaus, 1984, British journal of clinical pharmacology.

Effect of low-dose phenobarbitone on five indirect indices of hepatic microsomal enzyme induction and plasma lipoproteins in normal subjects.

E. Perucca, D. Betteridge, B. K. Park, 1981, British journal of clinical pharmacology.

Measurement of urinary 6-β-hydroxycortisol excretion as an in vivo parameter in the clinical assessment of the microsomal enzyme-inducing capacity of antipyrine, phenobarbitone and rifampicin

B. K. Park, E. Ohnhaus, B. Park, 1979, European Journal of Clinical Pharmacology.

MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury

B. K. Park, C. Goldring, B. K. Park, 2018, Expert review of molecular diagnostics.

Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men.

B. K. Park, R. Vestal, J. Koup, 1988, The Journal of pharmacology and experimental therapeutics.

An investigation of sex‐linked differences to the toxic and to the pharmacological actions of difenacoum: studies in mice and rats

M. J. Winn, B. K. Park, B. Park, 1987, The Journal of pharmacy and pharmacology.

Estimation of Rumen By-pass Rate of Chromium-methionine Chelates by Ruminal Bacteria Analysis

J. G. Park, B. K. Park, C. H. Kim, 2005 .

Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell‐Based Therapies

Dominic P. Williams, P. Andrews, D. Hay, 2015, Stem cells translational medicine.

Validation of methods involving miRNA isolation, purification and quantification and the potential of miRNAs to be used as biomarkers of nephrotoxicity

B. K. Park, D. Antoine, J. Sharkey, 2011 .

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000, AIDS research and human retroviruses.

Identification of a novel TGFBR2 gene mutation in a Korean patient with Loeys–Dietz aortic aneurysm syndrome; no mutation in TGFBR2 gene in 30 patients with classic Marfan's syndrome

C. Ki, B. K. Park, H. Yoo, 2005, Clinical genetics.

The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury

B. K. Park, D. Naisbitt, A. Tailor, 2015, Human & experimental toxicology.

Costimulatory Signaling Sulfamethoxazole Stimulate Dendritic Cell Sulfamethoxazole and Its Metabolite Nitroso

Charlotte A. Ashby, M. Pirmohamed, M. Rieder, 2007 .

Immunopharmacology of hypersensitivity reactions to drugs

M. Pirmohamed, B. K. Park, D. Naisbitt, 2003, Current allergy and asthma reports.

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2002, Molecular pharmacology.

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging.

B. K. Park, J. G. Kenna, S. Stahl, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Albumin and immunoglobulin depletion of human plasma.

N. Kitteringham, B. K. Park, R. Jenkins, 2008, Methods in molecular biology.

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01

M. Pirmohamed, A. Lister, B. K. Park, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation

B. K. Park, D. Naisbitt, A. Owen, 2015, AIDS.

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.

B. K. Park, D. Naisbitt, W. Pichler, 2011, The Journal of allergy and clinical immunology.

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

Andrew R. Jones, M. Pirmohamed, B. K. Park, 2012, Genome Medicine.

Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury.

Amy E. Chadwick, B. K. Park, D. Naisbitt, 2020, Chemical research in toxicology.

Definition of the Chemical and Immunological Signals Involved in Drug-induced Liver Injury.

B. K. Park, X. Meng, Kevin B. Park, 2020, Chemical research in toxicology.

Immune drug-induced liver disease and drugs

B. K. Park, D. Naisbitt, X. Meng, 2017, Current Opinion in Toxicology.

The Effect of Inhibitory Signals on the Priming of Drug Hapten–Specific T Cells That Express Distinct Vβ Receptors

M. Pirmohamed, B. K. Park, Andrew Gibson, 2017, The Journal of Immunology.

Promiscuous T-cell responses to drugs and drug-haptens.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2015, The Journal of allergy and clinical immunology.

Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury

M. Pirmohamed, B. K. Park, D. Naisbitt, 2015, Hepatology.

Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model.

A. Kipar, B. K. Park, D. Naisbitt, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22–Secreting T Cells and the Influence of PD-1 on Effector T Cell Function

Andrew Gibson, B. K. Park, D. Naisbitt, 2014, The Journal of Immunology.

Cell Function Cells and the Influence of PD-1 on Effector T Secreting T − Drug-Specific Priming of IL-22 Negative Regulation by PD-L 1 during

Andrew Gibson, B. K. Park, D. Naisbitt, 2014 .

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2013, Chemical research in toxicology.

The development of in vitro culture methods to characterize primary T-cell responses to drugs.

B. K. Park, D. Naisbitt, I. Schuppe-Koistinen, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis1

Munir, Manal, Pirmohamed, 2011 .

The pharmacokinetics of levonorgestrel and ethynylestradiol in women - studies with Ovran and Ovranette.

A. Breckenridge, B. K. Park, D. Back, 1981, Contraception.

Stereoselective interaction between the R enantiomer of warfarin and cimetidine.

A. Breckenridge, B. K. Park, S. Cholerton, 1986, British journal of clinical pharmacology.

Investigation of the immunogenicity of diclofenac and diclofenac metabolites.

B. K. Park, D. Naisbitt, X. Meng, 2007, Toxicology letters.

Are chemically reactive metabolites responsible for adverse reactions to drugs?

M. Pirmohamed, D. Smith, N. Kitteringham, 2002, Current drug metabolism.

Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

B. K. Park, S. Powell, G. Edwards, 1998, British journal of pharmacology.

The Effect of Fluorine Substitution on the Physicochemical Properties and the Analgesic Activity of Paracetamol

B. K. Park, P. O’Neill, S. Barnard, 1993, The Journal of pharmacy and pharmacology.

Fibrosisfrom Piperacillin in Patients with Cystic Circulating and Functional Antigens Derived Mass Spectrometric Characterization of

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011 .

The mechanism of bioactivation and antigen formation of amodiaquine in the rat.

N. Kitteringham, B. K. Park, J. Clarke, 1992, Biochemical pharmacology.

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.

M. Pirmohamed, B. K. Park, D. Naisbitt, 1998, Chemical research in toxicology.

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

Nico P E Vermeulen, Jan Snoeys, Magnus Ingelman-Sundberg, 2016, Archives of Toxicology.

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

Masayuki Yamamoto, J. Hayes, N. Kitteringham, 2010, Journal of proteomics.

Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro.

N. Kitteringham, B. K. Park, C. Goldring, 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.

Dominic P. Williams, J. G. Kenna, B. K. Park, 2009, Toxicology and applied pharmacology.

Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC)

N. Kitteringham, B. K. Park, C. Goldring, 2008, Phytotherapy research : PTR.

Effect of stanozolol on δ-aminolaevulinic acid synthase and hepatic monooxygenase activity in man and rat

C. Forbes, G. Lowe, B. K. Park, 2004, European Journal of Clinical Pharmacology.

Theuseofathree compartment invitro modeltoinvestigate the role ofhepatic drugmetabolism indrug-induced blood dyscrasias

B. K. Park, M. Tingle, 1993 .

The use of a three compartment in vitro model to investigate the role of hepatic drug metabolism in drug-induced blood dyscrasias.

B. K. Park, M. Tingle, B. Park, 1993, British journal of clinical pharmacology.

The effect of enzyme induction on the cytochrome P450-mediated bioactivation of carbamazepine by mouse liver microsomes.

M. Pirmohamed, A. Breckenridge, N. Kitteringham, 1992, Biochemical pharmacology.

Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes.

N. Kitteringham, B. K. Park, R. Riley, 1990, Biochemical pharmacology.

Sex-dependent sensitivity to dapsone-induced methaemoglobinaemia in the rat.

M. J. Winn, A. Breckenridge, B. K. Park, 1990, Biochemical pharmacology.

Structural requirements for bioactivation of anticonvulsants to cytotoxic metabolites in vitro.

N. Kitteringham, B. K. Park, R. Riley, 1989, British journal of clinical pharmacology.

A stereochemical investigation ofthecytotoxicity of mianserin metabolites invitro

N. Kitteringham, B. K. Park, R. Riley, 1989 .

A stereochemical investigation of the cytotoxicity of mianserin metabolites in vitro.

N. Kitteringham, B. K. Park, R. Riley, 1989, British journal of clinical pharmacology.

Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.

A. Breckenridge, B. K. Park, M. Coleman, 1989, British journal of clinical pharmacology.

Structural requirements forbioactivation ofanticonvulsants tocytotoxic metabolites invitro

B. K. Park, R. Riley, N. Ki, 1989 .

Activation of mianserin and its metabolites by human liver microsomes.

N. Kitteringham, B. K. Park, C. Lambert, 1989, Biochemical pharmacology.

A comparative study oftheformation ofchemically reactive drugmetabolites byhumanliver microsomes

N. Kitteringham, B. K. Park, J. Maggs, 1988 .

A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes.

N. Kitteringham, B. K. Park, J. Maggs, 1988, British journal of clinical pharmacology.

Drug-protein conjugates--II. An investigation of the irreversible binding and metabolism of 17 alpha-ethinyl estradiol in vivo.

B. K. Park, J. Maggs, P. Grabowski, 1983, Biochemical pharmacology.

Drug-protein conjugates--V. Sex-linked differences in the metabolism and irreversible binding of 17 alpha-ethinylestradiol in the rat.

B. K. Park, J. Maggs, P. Grabowski, 1983, Biochemical pharmacology.

The effects of phenobarbitone on urinary 6 beta-hydroxycortisol excretion and hepatic enzyme activity in the marmoset monkey (Callithrix jacchus).

T. Orton, B. K. Park, J. Odum, 1980, Biochemical pharmacology.

Cimetidine potentiates the anticoagulant effect of warfarin by inhibition of drug metabolism.

A. Breckenridge, B. K. Park, M. Serlin, 1980, Biochemical pharmacology.

Cytochrome P450 enzymes in the heart

B. K. Park, 2000, The Lancet.

Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4+ T Cells from Allergic Individuals1

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000, The Journal of Immunology.

Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity.

M. Pirmohamed, B. K. Park, A. Alfirevic, 2003, British journal of clinical pharmacology.

Cimetidine increases the action of warfarin in man [proceedings].

A. Breckenridge, B. K. Park, M. Serlin, 1979, British journal of clinical pharmacology.

The effect of low-dose phenobarbitone on three indices of hepatic microsomal enzyme induction.

M. Feely, B. K. Park, A. Hay, 1986, British journal of clinical pharmacology.

Drug-protein conjugates--XVII. The effect of storage on the antigenicity and immunogenicity of benzylpenicillin in the rat.

B. K. Park, G. Christie, J. Coleman, 1988, Biochemical pharmacology.

Drug-protein conjugates--XV. A study of the disposition of D-penicillamine in the rat and its relationship to immunogenicity.

B. K. Park, J. Yeung, J. Coleman, 1988, Biochemical pharmacology.

Drug-protein conjugates--XII. A study of the disposition, irreversible binding and immunogenicity of penicillin in the rat.

N. Kitteringham, B. K. Park, G. Christie, 1987, Biochemical pharmacology.

Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome

N. Kitteringham, B. K. Park, R. Eakins, 2015, Scientific Reports.

Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway.

N. Kitteringham, B. K. Park, C. Goldring, 2007, Life sciences.

An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1993, Biochemical Pharmacology.

Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men.

B. K. Park, R. Vestal, B. Cusack, 1987, The Journal of pharmacology and experimental therapeutics.

Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method.

M. Pirmohamed, I. Wilson, M. Coen, 2014, Bioanalysis.

Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer

H. Grabsch, W. Greenhalf, Eithne Costello, 2010, Gut.

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug‐induced liver injury and postinjury inflammation in mice

K. Tracey, Huan Yang, J. Stéen, 2016, Hepatology.

Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity.

Dominic P. Williams, R. Obach, B. K. Park, 2009, Chemico-biological interactions.

Autoxidative formation of a chemically reactive intermediate from amodiaquine, a myelotoxin and hepatotoxin in man.

A. Breckenridge, N. Kitteringham, B. K. Park, 1987, Biochemical pharmacology.

Immunogenicity of amodiaquine in the rat.

N. Kitteringham, B. K. Park, J. Maggs, 1990, International archives of allergy and applied immunology.

Detection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitis.

N. Kitteringham, B. K. Park, J. G. Kenna, 1995, British journal of clinical pharmacology.

Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine.

K. Neftel, N. Kitteringham, B. K. Park, 1991, International archives of allergy and applied immunology.

Direct and metabolism-dependent toxicity of sulphasalazine and its principal metabolites towards human erythrocytes and leucocytes.

M. Pirmohamed, A. Breckenridge, B. K. Park, 1991, British journal of clinical pharmacology.

Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine.

M. Pirmohamed, B. K. Park, I. Strickland, 1994, Archives of dermatology.

Development of a monoclonal antibody to 6β-hydroxycortisol and its application in an enzyme-linked immunosorbent assay (ELISA) for 6β-hydroxycortisol in urine

B. K. Park, J. Yeung, J. Wong, 1997 .

Enzyme-linked immunosorbent assay (ELISA) for detection of antibodies to protein-reactive drugs and metabolites: criteria for identification of antibody activity. Detection and hapten specificity of anti-DNP, anti-captopril and anti-sulphanilamidobenzoic acid.

B. K. Park, J. Yeung, M. Tingle, 1986, Journal of immunological methods.

Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay.

J. Ashby, J. Sumpter, D. Paton, 2001, The Journal of pharmacology and experimental therapeutics.

Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor.

J. Ashby, P. Lefevre, W. Pennie, 2000, Biochemical pharmacology.

Cortisol metabolism in vitro—II. Species difference

B. K. Park, D. Back, J. Maggs, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Characterisation of Sulfamethoxazole and Sulfamethoxazole Metabolite-Specific T-cell Responses in Animals and Man

M. Pirmohamed, B. K. Park, D. Naisbitt, 2003 .

T Cells from Allergic Individuals + Reactive Metabolites by Drug-Specific CD 4 Recognition of Sulfamethoxazole and Its

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000 .

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.

H. Jaeschke, K. Dorko, S. Kumer, 2015, Toxicology and applied pharmacology.

Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study

R. Jalan, B. K. Park, C. Goldring, 2015, Journal of hepatology.

Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites

B. K. Park, D. Naisbitt, J. Maggs, 2008, Drug Metabolism and Disposition.

Bioactivation and bioinactivation of drugs and drug metabolites: Relevance to adverse drug reactions.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1994, Toxicology in vitro : an international journal published in association with BIBRA.

Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy.

M. Pirmohamed, D. Chadwick, N. Kitteringham, 1994, British journal of clinical pharmacology.

Assessment of enzyme induction and enzyme inhibition in humans: toxicological implications.

N. Kitteringham, B. K. Park, B. Park, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Drug disposition and drug hypersensitivity.

N. Kitteringham, B. K. Park, J. Coleman, 1987, Biochemical pharmacology.

An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin.

N. Kitteringham, B. K. Park, J. Maggs, 1988, British journal of clinical pharmacology.

Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells.

Andrew Gibson, B. K. Park, D. Naisbitt, 2017, The Journal of allergy and clinical immunology.

Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2010, The Journal of investigative dermatology.

Dexamethasone Metabolism in Species Differences Vitro

B. K. Park, E. Tomlinson, D. Back, 1997 .

Dexamethasone metabolism in vitro: Species differences

B. K. Park, E. Tomlinson, D. Back, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

Effect of isoniazid on vitamin D metabolism and hepatic monooxygenase activity

M. Brodie, A. Boobis, B. K. Park, 1981, Clinical pharmacology and therapeutics.

Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2012, Pharmacogenomics.

Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells.

M. Pirmohamed, B. K. Park, D. Antoine, 2010, Biochemical pharmacology.

Effects of β-Glucan from Paenibacillus polymyxa and L-theanine on Growth Performance and Immunomodulation in Weanling Piglets

J. Lim, B. K. Park, S. C. Park, 2008 .

Catecholestrogens as mediators of carcinogenesis: correlation of aromatic hydroxylation of estradiol and its fluorinated analogs with tumor induction in Syrian hamsters.

B. K. Park, J. Maggs, T. L. Gilchrist, 1994, Molecular pharmacology.

Assessment of urinary 6 beta-hydroxycortisol as an in vivo index of mixed-function oxygenase activity.

B. K. Park, B. Park, 1981, British journal of clinical pharmacology.

The Estimation of 6β-Hydroxycortisol in Urine — A Comparison of Two Methods: High Performance Liquid Chromatography and Radioimmunoassay

B. K. Park, E. Ohnhaus, E. Gerber-Taras, 1981, Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.

Novel OCT1 and OCT2 genetic variations—Potential link to metformin associated vitamin B12 deficiency during diabetes

M. Pirmohamed, B. K. Park, D. Antoine, 2011 .

Interaction between warfarin and propranolol.

A. Breckenridge, B. K. Park, A. Scott, 1984, British journal of clinical pharmacology.

Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals.

Andrew A. White, Dominic P. Williams, M. Pirmohamed, 2010, The Journal of investigative dermatology.

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

B. K. Park, V. Barton, G. Nixon, 2010, Angewandte Chemie.

Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: evidence for endoperoxide bioactivation.

B. K. Park, P. O’Neill, J. Maggs, 1999, The Journal of pharmacology and experimental therapeutics.

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component

B. K. Park, D. Naisbitt, S. Ward, 1996, Antimicrobial agents and chemotherapy.

verapamil-sensitive chloroquine resistance amodiaquine to overcome the Manipulation of the N-alkyl substituent in

B. K. Park, D. Naisbitt, P. O’Neill, 1996 .

Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.

B. K. Park, S. Ward, P. O’Neill, 2001, Journal of medicinal chemistry.

The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials*

B. K. Park, P. O’Neill, J. Maggs, 2010, The Journal of Biological Chemistry.

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.

B. K. Park, S. Ward, P. O’Neill, 2002, Journal of medicinal chemistry.

Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical.

B. K. Park, S. Ward, P. O’Neill, 2000, The Journal of organic chemistry.

Biliary metabolites of beta-artemether in rats: biotransformations of an antimalarial endoperoxide.

B. K. Park, S. Ward, P. O’Neill, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds*

G. Cohen, B. K. Park, James Chadwick, 2007, Journal of Biological Chemistry.

Enantiomers of warfarin and vitamin K1 metabolism.

A. Breckenridge, B. K. Park, S. Cholerton, 1986, British journal of clinical pharmacology.

Idiosyncratic reactions to antidepressants: a review of the possible mechanisms and predisposing factors.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1992, Pharmacology & therapeutics.

Effect of rifampicin and isoniazid on vitamin D metabolism

M. Brodie, A. Boobis, B. K. Park, 1982, Clinical pharmacology and therapeutics.

Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.

Dominic P. Williams, H. Jaeschke, B. K. Park, 2011, Toxicology and applied pharmacology.

Genetic susceptibility to adverse drug reactions.

M Pirmohamed, M. Pirmohamed, B. K. Park, 2001, Trends in pharmacological sciences.

No association between tacrine transaminitis and the glutathione transferase theta genotype in patients with Alzheimer's disease.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1998, Pharmacogenetics.

Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism.

M. Pirmohamed, B. K. Park, Kevin B. Park, 1996, Clinical pharmacokinetics.

SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?† †Electronic supplementary information (ESI) available: pXRD, DLS, zeta potential, TEM, TGA, MRI and XANES. See DOI: 10.1039/c7bm00515f

B. K. Park, D. Adams, P. Mandal, 2017, Biomaterials science.

Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells.

Eithne Costello, J. Neoptolemos, S. Tonack, 2010, Carcinogenesis.

Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers

M. Monshouwer, B. K. Park, Andrew Gibson, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

Min Wei Wong, M. Ingelman-Sundberg, M. Cross, 2015, Free radical biology & medicine.

Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity.

J. Dear, B. K. Park, C. Goldring, 2014, Zebrafish.

Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity

Amy E. Chadwick, Dominic P. Williams, M. Monshouwer, 2019, Current protocols in toxicology.

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat.

M. Pirmohamed, Research Fellow, N. Kitteringham, 1997, The Journal of pharmacology and experimental therapeutics.

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

B. K. Park, C. Goldring, M. Searle, 2013, Bone.

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.

B. K. Park, James Chadwick, P. O’Neill, 2009, Bioorganic & medicinal chemistry.

Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.

C. Davis, B. K. Park, Peter D Gibbons, 2009, Journal of medicinal chemistry.

A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.

B. K. Park, G. Biagini, N. Berry, 2006, Current topics in medicinal chemistry.

Drug-protein conjugates--IX. Immunogenicity of captopril-protein conjugates.

B. K. Park, J. Yeung, J. Coleman, 1985, Biochemical pharmacology.

Reduction of circulating 25-hydroxyvitamin D by antipyrine.

J. Mucklow, C. Dollery, M. Brodie, 1979, British journal of clinical pharmacology.

On the mechanism of salicylate‐induced hypothrombinaemia

B. K. Park, B. K. Park, J. Leck, 1981, The Journal of pharmacy and pharmacology.

Hepatic enzyme induction and vitamin K1 elimination in man

B. K. Park, A. Scott, E. Ohnhaus, 2004, European Journal of Clinical Pharmacology.

Drug-specific antibodies in patients receiving captopril.

A. Breckenridge, B. K. Park, J. Yeung, 1986, British journal of clinical pharmacology.

Microsomal enzyme induction in children: the influence of carbamazepine treatment on antipyrine kinetics, 6 beta-hydroxycortisol excretion and plasma gamma-glutamyltranspeptidase activity.

T. Moreland, B. K. Park, G. Rylance, 1982, British journal of clinical pharmacology.

Rifampicin and vitamin D metabolism

M. Brodie, A. Boobis, D. Brown, 1980, Clinical pharmacology and therapeutics.

Erratum: Characterisation of the toxic metabolite(s) of naphthalene (Toxicology 114 (1996) (233)) PII S0300483X96035159

Dominic P. Williams, M. Pirmohamed, C. Davis, 1997 .

Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies.

A. Kipar, B. K. Park, C. Goldring, 2017, Toxicology research.

Optimising the use of medicines to reduce acute kidney injury in children and babies

B. K. Park, M. Turner, M. Beresford, 2017, Pharmacology & therapeutics.

β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2013, Chemical research in toxicology.

Rifampicin and vitamin D metabolism in man [proceedings].

M. Brodie, A. Boobis, D. Brown, 1980, British journal of clinical pharmacology.

Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science.

Dominic P. Williams, B. K. Park, D. Antoine, 2008, Expert opinion on drug metabolism & toxicology.

Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models.

Amy E. Chadwick, B. K. Park, Neil S French, 2021, Toxicology in vitro : an international journal published in association with BIBRA.

Effects of Maternal Nursing Potential on Blood Metabolites, Body Weight Gain and Disease Occurrence of Hanwoo Calves

Y. M. Cho, E. Kwon, B. K. Park, 2006 .

Effects of Ad libitum and Restricted Feeding of Concentrates on Body Weight Gain, Feed Intake and Blood Metabolites of Hanwoo Steers at Various Growth Stages

Y. M. Cho, E. Kwon, B. K. Park, 2005 .

Formation of cytotoxic protein reactive metabolites from furosemide: Biological consequences of drug metabolism

Dominic P. Williams, B. K. Park, D. Antoine, 2007 .

Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1995, Pharmacogenetics.

Polymorphism in gene for microsomal epoxide hydrolase and lung disease

M. Pirmohamed, N. Kitteringham, B. K. Park, 1997, The Lancet.

Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase.

B. K. Park, D. Naisbitt, R. Jenkins, 2015, Chemical research in toxicology.

A study of the relationship between the pharmacokinetics and the pharmacodynamics of the 4-hydroxycoumarin anticoagulants warfarin, difenacoum and brodifacoum in the rabbit.

A. Breckenridge, B. K. Park, S. Cholerton, 1985, British journal of pharmacology.

The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: chemical mechanisms and the effects of fluorine substitution.

B. K. Park, P. O’Neill, J. Maggs, 1995, Biochemical pharmacology.

The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro.

B. K. Park, S. Ward, G. Edwards, 2001, Biochemical pharmacology.

Understanding the pathophysiological regulatory role of microRNAs in acute liver failure

J. Dear, B. K. Park, C. Goldring, 2015, Hepatology.

Kinetic parameters of lymphocyte microsomal epoxide hydrolase in carbamazepine hypersensitive patients. Assessment by radiometric HPLC.

M. Pirmohamed, D. Smith, N. Kitteringham, 1995, Biochemical pharmacology.

Metabolism of fluorine-containing drugs.

N. Kitteringham, B. K. Park, P. O’Neill, 2001, Annual review of pharmacology and toxicology.

Synthesis of the 8-aminoquinoline antimalarial 5-fluoroprimaquine

B. K. Park, P. O’Neill, R. C. Storr, 1998 .

The effect of fluorine substitution on the haemotoxicity of Primaquine

B. K. Park, S. Ward, P. O’Neill, 1995 .

New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain.

B. K. Park, P. Stocks, S. Ward, 1999, Journal of medicinal chemistry.

Antitumour and antimalarial activity of artemisinin-acridine hybrids.

J. Baird, I. Piantanida, B. K. Park, 2009, Bioorganic & medicinal chemistry letters.

Mechanisms of action of the anticoagulants warfarin, 2-chloro-3-phytylnaphthoquinone (Cl-K), acenocoumarol, brodifacoum and difenacoum in the rabbit [proceedings].

A. Breckenridge, B. K. Park, M. Serlin, 1978, British journal of pharmacology.

Ruth H. Hughes, B. K. Park, P. Stocks, 2003, Journal of medicinal chemistry.

Effect of Disposition of Mannich Antimalarial Agents on Their Pharmacology and Toxicology

B. K. Park, S. Ward, P. O’Neill, 1998, Antimicrobial Agents and Chemotherapy.

Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues

B. K. Park, S. Ward, P. O’Neill, 2001 .

Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1,2,4-trioxanes

B. K. Park, S. Ward, P. O’Neill, 2001 .

Co(thd)2: a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes

B. K. Park, P. Stocks, S. Ward, 2003 .

Metabolic and chemical origins of cross-reactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives.

B. K. Park, D. Naisbitt, P. O’Neill, 2010, Chemical research in toxicology.

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.

B. K. Park, James Chadwick, P. Stocks, 2010, Bioorganic & medicinal chemistry.

Acyl glucuronides: the good, the bad and the ugly.

Dominic P. Williams, B. K. Park, J. Maggs, 2010, Biopharmaceutics & drug disposition.

Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.

K. Beaumont, B. K. Park, R. Jenkins, 2007, Journal of medicinal chemistry.

A survey of the prevalence of penicillin-specific IgG, IgM and IgE antibodies detected by ELISA and defined by hapten inhibition, in patients with suspected penicillin allergy and in healthy volunteers.

A. Breckenridge, B. K. Park, G. Christie, 1988, British journal of clinical pharmacology.

Altered pharmacokinetics of enrofloxacin in experimental models of hepatic and renal impairment

B. K. Park, I. Song, H. Yun, 2009, Veterinary Research Communications.

Warfarin: metabolism and mode of action.

B. K. Park, B. Park, 1988, Biochemical pharmacology.

Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix.

B. K. Park, M. Heo, H. P. Kim, 2001, European journal of pharmacology.

Immunological Principles of Adverse Drug Reactions

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000, Drug safety.

Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1992, British journal of clinical pharmacology.

Comparison of the metabolism and toxicity of dapsone in rat, mouse and man.

M. Pirmohamed, B. K. Park, J. Maggs, 1997, The Journal of pharmacology and experimental therapeutics.

The role of metabolic activation in drug-induced hepatotoxicity.

Munir Pirmohamed, Dominic P. Williams, M. Pirmohamed, 2005, Annual review of pharmacology and toxicology.

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.

J. Bibby, N. Kitteringham, B. K. Park, 2016, Journal of medicinal chemistry.

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation in vivo

M. Pirmohamed, B. K. Park, D. Naisbitt, 2001, British journal of pharmacology.

The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man.

A. Breckenridge, B. K. Park, M. Coleman, 1990, British journal of clinical pharmacology.

Inhibition of Dapsone‐induced Methaemoglobinaemia in the Rat Isolated Perfused Liver

A. Breckenridge, B. K. Park, M. Coleman, 1990, The Journal of pharmacy and pharmacology.

N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity.

B. K. Park, M. Tingle, H. Gill, 1995, British journal of clinical pharmacology.

Cimetidine improves the therapeutic/toxic ratio of dapsone in patients on chronic dapsone therapy

B. K. Park, P. Friedmann, L. Rhodes, 1995, The British journal of dermatology.

The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients.

A. Breckenridge, L. Rhodes, B. K. Park, 1992, British journal of clinical pharmacology.

Inhibition of Dapsone‐induced Methaemoglobinaemia by Cimetidine in the Presence of Trimethoprim in the Rat

R. Russell, B. K. Park, M. Coleman, 1992, The Journal of pharmacy and pharmacology.

Effect of rifampicin on haem and bilirubin metabolism in man.

M. Brodie, B. K. Park, M. Moore, 1987, British journal of clinical pharmacology.

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.

Dominic P. Williams, B. K. Park, James Chadwick, 2004, Journal of medicinal chemistry.

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

M Pirmohamed, M. Pirmohamed, N. Kitteringham, 1999, British journal of pharmacology.

HLA‐DQ allele‐restricted activation of nitroso sulfamethoxazole‐specific CD4‐positive T lymphocytes from patients with cystic fibrosis

M. Pirmohamed, A. Sette, B. K. Park, 2015, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Idiosyncratic toxicity: the role of toxicophores and bioactivation.

Dominic P. Williams, B. K. Park, Dominic P Williams, 2003, Drug discovery today.

Reactive metabolites and their role in drug reactions

Dominic P. Williams, M. Pirmohamed, N. Kitteringham, 2001, Current opinion in allergy and clinical immunology.

Metabolic activation in drug allergies.

M. Pirmohamed, N. Kitteringham, B. K. Park, 2001, Toxicology.

Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity.

M Pirmohamed, M. Pirmohamed, N. Kitteringham, 2000, Toxicology.

The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole.

M. Pirmohamed, B. K. Park, J. Maggs, 2003, British journal of clinical pharmacology.

TNFα promoter region gene polymorphisms in carbamazepine-hypersensitive patients

M. Pirmohamed, B. K. Park, D. Chadwick, 2001, Neurology.

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1995, Pharmacology & therapeutics.

Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases.

M. Pirmohamed, B. Burchell, B. K. Park, 2002, Drug metabolism and disposition: the biological fate of chemicals.

The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide.

B. K. Park, P. O’Neill, J. Maggs, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Drug-protein conjugates--XVIII. Detection of antibodies towards the antimalarial amodiaquine and its quinone imine metabolite in man and the rat.

A. Breckenridge, B. K. Park, G. Christie, 1989, Biochemical pharmacology.

HIV and drug allergy

M Pirmohamed, M. Pirmohamed, B. K. Park, 2001, Current opinion in allergy and clinical immunology.

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes.

B. K. Park, S. Madden, T. Woolf, 1994, British journal of clinical pharmacology.

Assessing the safety of stem cell therapeutics.

Jens Kurth, Gopalan Narayanan, Hugh Laverty, 2011, Cell stem cell.

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

Rosalind E. Jenkins, Magnus Ingelman-Sundberg, Robert P. Jones, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Diet Restriction Inhibits Apoptosis and HMGB1 Oxidation and Promotes Inflammatory Cell Recruitment during Acetaminophen Hepatotoxicity

Dominic P. Williams, H. Laverty, A. Kipar, 2010, Molecular medicine.

Effects of Diet and Time on Feed on Fatty Acid Composition in Muscle of Charolais Steers

E. Kwon, B. K. Park, W. Cho, 2006 .

Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.

B. K. Park, P. O’Neill, J. Maggs, 2001, Journal of medicinal chemistry.

4-Aminoquinolines--past, present, and future: a chemical perspective.

B. K. Park, S. Ward, P. O’Neill, 1998, Pharmacology & therapeutics.

The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity

B. K. Park, D. Naisbitt, B. K. Park, 2008, Current opinion in allergy and clinical immunology.

Metabolism of lamotrigine to a reactive arene oxide intermediate.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000, Chemical research in toxicology.

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.

Dominic P. Williams, M. Pirmohamed, B. K. Park, 1995, The Journal of pharmacology and experimental therapeutics.

Metabolism and bioactivation of clozapine by human liver in vitro.

Dominic P. Williams, M. Pirmohamed, B. K. Park, 1995, The Journal of pharmacology and experimental therapeutics.

The effects of chronic carbamazepine treatment on haem biosynthesis in man and rat

M. Brodie, B. K. Park, M. Moore, 2004, European Journal of Clinical Pharmacology.

Effects of cimetidine on carbamazepine auto- and hetero-induction in man.

B. K. Park, G. Macphee, K. McColl, 1984, British journal of clinical pharmacology.

Hepatic enzyme induction and leucocyte delta-aminolaevulinic acid synthase activity: studies with carbamazepine.

W. Rapeport, B. K. Park, M. Brodie, 1983, British journal of clinical pharmacology.

Effect of stanozolol on delta-aminolaevulinic acid synthase and hepatic monooxygenase activity in man and rat.

C. Forbes, G. Lowe, B. K. Park, 1984, European journal of clinical pharmacology.

The metabolism of 2,4-dibromo [6,7-3H]17β-oestradiol in the rat: Ring-A dibromination blocks male-specific 15α-hydroxylation and catechol formation

B. K. Park, J. Maggs, P. C. Page, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems.

D A Smith, D. Smith, N. Kitteringham, 1995, British journal of clinical pharmacology.

Acyl glucuronides: biological activity, chemical reactivity, and chemical synthesis.

John C Lindon, Ian D Wilson, I. Wilson, 2006, Journal of medicinal chemistry.

The effect of phenobarbitone pre-treatment on vitamin K1 disposition in the rat and rabbit.

B. K. Park, A. Wilson, B. Park, 1984, Biochemical pharmacology.

Quantitative analysis of pharmacological levels of vitamin K1 and vitamin K1 2,3-epoxide in rabbit plasma by high-performance liquid chromatography.

B. K. Park, A. Wilson, B. Park, 1983, Journal of chromatography.

Quantitative analysis of pharmacological concentrations of vitamin K1 and vitamin K1 2,3-epoxide in rat liver by high-performance liquid chromatography

B. K. Park, S. Cholerton, B. Park, 1986 .

Stem cell models as an in vitro model for predictive toxicology

B. K. Park, C. Goldring, Parveen Sharma, 2019, The Biochemical journal.

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation.

B. K. Park, C. Goldring, B. K. Park, 2013, Biochemical pharmacology.

From mice to men: Murine models of colorectal cancer for use in translational research.

Eithne Costello, D. Palmer, N. Kitteringham, 2016, Critical reviews in oncology/hematology.

Bioactivation and inactivation of aflatoxin B1 by human, mouse and rat liver preparations: effect on SCE in human mononuclear leucocytes.

C. Davis, B. K. Park, M. Tingle, 1997, Mutation research.

Drug Bioactivation and Oxidative Stress

Dominic P. Williams, H. Laverty, B. K. Park, 2012 .

3 The pharmacology of the cytochrome P450 enzyme system

M. Pirmohamed, N. Kitteringham, B. K. Park, 1998 .

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

K. G. Jensen, Amy E. Chadwick, Dominic P. Williams, 2019, Nature Reviews Drug Discovery.

Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore

Ian D. Wilson, John R. Harding, Dominic P. Williams, 2008, Journal of Pharmacology and Experimental Therapeutics.

Metabolism of ciamexon by human liver microsomes: an investigation into the formation of stable, chemically reactive and cytotoxic metabolites.

B. K. Park, M. Tingle, B. Park, 1990, British journal of clinical pharmacology.

Vitamin K1 metabolism in relation to pharmacodynamic response in anticoagulated patients.

A. Breckenridge, B. K. Park, S. Cholerton, 1985, British journal of clinical pharmacology.

Clinical Pharmacokinetics of Tacrine

B. K. Park, S. Madden, V. Spaldin, 1995, Clinical pharmacokinetics.

Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries

Dominic P. Williams, M. Pirmohamed, L. Lian, 2010, Drug Metabolism and Disposition.

Role of reactive metabolites in drug-induced hepatotoxicity.

D A Smith, Dominic P. Williams, D. Smith, 2010, Handbook of experimental pharmacology.

Drug hypersensitivity reactions in patients with HIV disease

M. Pirmohamed, B. K. Park, D. Naisbitt, 2007, Expert review of clinical immunology.

Efficient synthesis of 1β-O-acyl glucuronides via selective acylation of allyl or benzyl d-glucuronate

John R. Harding, B. K. Park, J. Maggs, 2007 .

Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.

B. K. Park, J. Maggs, X. Meng, 2004, Journal of medicinal chemistry.

Pharmacology and Toxicology Antimalarial Agents on Their Effect of Disposition of Mannich

B. K. Park, S. Ward, P. O’Neill, 1998 .

Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine.

B. K. Park, S. Ward, P. Bray, 1996, Molecular and biochemical parasitology (Print).

Drug-protein conjugates--XIV. Mechanisms of formation of protein-arylating intermediates from amodiaquine, a myelotoxin and hepatotoxin in man.

N. Kitteringham, B. K. Park, J. Maggs, 1988, Biochemical pharmacology.

Human pluripotent stem cells for modeling toxicity.

N. Hanley, M. Cross, N. Kitteringham, 2012, Advances in pharmacology.

Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers.

Dominic P. Williams, A. Kipar, B. K. Park, 2013, Toxicology.

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients

Dominic P. Williams, J. G. Kenna, G. Aithal, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients

Dominic P. Williams, J. G. Kenna, G. Aithal, 2014, The Journal of Pharmacology and Experimental Therapeutics.

The danger hypothesis--potential role in idiosyncratic drug reactions.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2002, Toxicology.

Genetic determinants of dose optimisation: molecular biology in the prevention of drug toxicity

M. Pirmohamed, B. K. Park, 2001 .

The immunological basis of adverse drug reactions. A report on a symposium held in Liverpool on 6th April 1988.

B. K. Park, J. Coleman, 1988, British journal of clinical pharmacology.

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

M. Ingelman-Sundberg, V. Lauschke, R. Weaver, 2016, Archives of Toxicology.

Managing the challenge of chemically reactive metabolites in drug development

Ian D. Wilson, Alan Boobis, Chris E. P. Goldring, 2011, Nature Reviews Drug Discovery.

The effect of 2,2'-substitution on the metabolism and toxicity of dapsone in vitro and in vivo.

B. K. Park, S. Ward, M. Coleman, 1998, Environmental toxicology and pharmacology.

2-Hydroxylation of ethinyloestradiol in relation to the oxidation of sparteine and antipyrine.

B. K. Park, D. Back, J. Maggs, 1984, British journal of clinical pharmacology.

Effect of chloroquine and primaquine on antipyrine metabolism.

B. K. Park, D. Back, S. Ward, 1983, British journal of clinical pharmacology.

The biotransformation of 17 alpha-ethynyl[3H]estradiol in the rat: irreversible binding and biliary metabolites.

B. K. Park, J. Maggs, P. Grabowski, 1982, Xenobiotica; the fate of foreign compounds in biological systems.

The effect of enzyme induction on diazepam metabolism in man.

B. K. Park, P. Heizmann, E. Ohnhaus, 1979, British journal of clinical pharmacology.

The effect of rifampicin on norethisterone pharmacokinetics

B. K. Park, D. Back, M. Maciver, 1979, European Journal of Clinical Pharmacology.

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

H. Laverty, B. K. Park, D. Naisbitt, 2011, Chemico-biological interactions.

Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation.

B. K. Park, E. Tomlinson, D. Back, 1996, The Journal of pharmacology and experimental therapeutics.

S-OS Prediction of metabolic drug interactions involving , 3-adrenoceptor blocking drugs

B. K. Park, 2006 .

No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury.

B. K. Park, D. Naisbitt, C. Spraggs, 2016, Chemical research in toxicology.

Structure-metabolism relationships of ring-A halogenated analogues of 17α-ethynyloestradiol

B. K. Park, J. Maggs, N. M. Bonham, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

Protection of catechol oestrogen from oxidation during enzymic hydrolysis of biliary conjugates.

B. K. Park, J. Maggs, P. Grabowski, 1983, Journal of steroid biochemistry.

Regioselective synthesis of a-ring halogenated derivatives of 17α-ethynyloestradiol

B. K. Park, J. Maggs, P. C. Page, 1991 .

Application of the TMSOTfAgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin

B. K. Park, S. Ward, P. O’Neill, 1999 .

Thermal conductivity as a probe for real-time PCR

G. Lim, B. K. Park, Joo Sung Kim, 2007 .

A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat

B. K. Park, C. Goldring, I. Schuppe-Koistinen, 2017, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity

J. Bowes, N. Hanley, J. Sidaway, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers

P. Watkins, D. Pisetsky, B. K. Park, 2012, Clinical pharmacology and therapeutics.

Validation of the isolation and quantification of kidney enriched miRNAs for use as biomarkers

B. K. Park, D. Antoine, J. Sharkey, 2012, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2018, Chemical research in toxicology.

Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver.

M. Pirmohamed, D. Chadwick, B. K. Park, 2005, British journal of clinical pharmacology.

Donor‐Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Cells

T. Liloglou, N. Kitteringham, B. K. Park, 2017, Stem cells translational medicine.

Application of Pluripotent Stem Cells in Drug‐Induced Liver Injury Safety Assessment

N. Kitteringham, B. K. Park, C. Goldring, 2016 .

Safety perspectives on presently considered drugs for the treatment of COVID‐19

Amy E. Chadwick, M. Pirmohamed, S. Khoo, 2020, British journal of pharmacology.

S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility

Eithne Costello, J. Neoptolemos, P. Navarro, 2009, British Journal of Cancer.

Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells.

R. Glazer, B. K. Park, Xiao Zeng, 2001, Cancer research.

Cytochrome P450 enzyme polymorphisms and adverse drug reactions.

Munir Pirmohamed, M. Pirmohamed, B. K. Park, 2003, Toxicology.

Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?

N. Hanley, N. Kitteringham, B. K. Park, 2013, British journal of clinical pharmacology.

Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing

Min Wei Wong, B. K. Park, C. Goldring, 2018 .

Characterisation of the toxic metabolite(s) of naphthalene.

M Pirmohamed, Dominic P. Williams, M. Pirmohamed, 1996, Toxicology.

Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management.

D. Palmer, N. Kitteringham, B. K. Park, 2018, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response.

J. Parsons, D. Palmer, N. Kitteringham, 2018, Journal of proteomics.

Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine.

M Pirmohamed, Dominic P. Williams, M. Pirmohamed, 2000, Molecular pharmacology.

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis.

M Pirmohamed, Dominic P. Williams, M. Pirmohamed, 1997, The Journal of pharmacology and experimental therapeutics.

Role of Nrf2 in protection against acute kidney injury.

B. K. Park, I. Copple, Luke M. Shelton, 2013, Kidney international.

Glutathione‐S‐transferase pi as a model protein for the characterisation of chemically reactive metabolites

N. Vermeulen, N. Kitteringham, B. K. Park, 2008, Proteomics.

Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury

J. Dear, B. K. Park, D. Antoine, 2015, Scientific Reports.

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

Alasdair J Gray, D. Webb, J. Dear, 2013, Hepatology.

Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation.

B. K. Park, A. Tailor, X. Meng, 2016, Chemical research in toxicology.

MDM2 regulates dihydrofolate reductase activity through monoubiquitination.

B. K. Park, R. Jenkins, M. Boyd, 2008, Cancer research.

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis

M. Pirmohamed, B. K. Park, D. Naisbitt, 2012, Journal of Pharmacology and Experimental Therapeutics.

Drug-protein conjugates--XIII. The disposition of the benzylpenicilloyl hapten conjugated to albumin.

N. Kitteringham, B. K. Park, G. Christie, 1987, Biochemical pharmacology.

The metabolism of 2,4-dibromo-17α-ethynyl[6,7-3H]oestradiol in the rat

B. K. Park, J. Maggs, F. Hussain, 1990 .

Effects of Fermented Feedstuff with Wet Brewer’s Grain and Soybean on Fattening Performance and Carcass Grade in hanwoo Steers

B. K. Park, C. Ra, J. Shin, 2003 .

Effect of Alcohol Fermented Feed on Lactating Performance, Blood Metabolites, Milk Fatty Acid Profile and Cholesterol Content in Holstein Lactating Cows

B. K. Park, J. S. Ahn, C. Yan, 2012, Asian-Australasian journal of animal sciences.

The metabolism of 2- and 4-fluoro-17 beta-oestradiol in the rat and its implications for oestrogen carcinogenesis.

B. K. Park, J. Maggs, P. Morgan, 1992, Biochemical pharmacology.

In vivo methods to study enzyme induction and enzyme inhibition.

B. K. Park, 1987, Pharmacology & therapeutics.

Metabolic Models of Cytotoxicity

M. Pirmohamed, B. K. Park, B. Park, 1999 .

Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science

Dominic P. Williams, B. K. Park, D. Antoine, 2008 .

Therelationship between inhibition ofvitamin K12,3-epoxide reductase andreduction ofclotting factor activity withwarfarin

A. Breckenridge, B. K. Park, C. Hay, 1988 .

The potential of cytokines as safety biomarkers for drug-induced liver injury

Dominic P. Williams, H. Laverty, B. K. Park, 2010, European Journal of Clinical Pharmacology.

Enzyme-inducing drug combinations and their effects on liver microsomal enzyme activity in man

B. K. Park, E. Ohnhaus, E. Gerber-Taras, 1983, European Journal of Clinical Pharmacology.

Sulphaphenazole and drug oxidation in man.

B. K. Park, D. Back, J. Tjia, 1983, British journal of clinical pharmacology.

Chapter 37 Idiosyncratic drug reactions

M. Pirmohamed, B. K. Park, 1997 .

Kinetics of norethindrone in women; I. Radioimmunoassay and concentrations during multiple dosing

A. Breckenridge, B. K. Park, D. Back, 1978, Clinical pharmacology and therapeutics.

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine

M. Pirmohamed, A. Marson, B. K. Park, 2020, British journal of clinical pharmacology.

Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells*

L. Djouhri, S. Sethu, N. Kitteringham, 2012, The Journal of Biological Chemistry.

An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro.

M. Pirmohamed, A. Breckenridge, N. Kitteringham, 1992, Biochemical pharmacology.

Clinical application of whole-genome sequenc- ing in patients with primary immunodeficiency

B. K. Park, D. Naisbitt, R. Jenkins, 2015 .

Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study

M. Pirmohamed, J. Bonventre, T. Farragher, 2012, PloS one.

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

J. S. Miles, N. Kitteringham, B. K. Park, 1992, The Biochemical journal.

The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore

Julian Blagg, Iain Gardner, Dominic P. Williams, 2007, Journal of Pharmacology and Experimental Therapeutics.

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

Fiona Campbell, Andrew Owen, Eithne Costello, 2011, Molecular Cancer.

Induction of mixed function oxidase activity in man by rifapentine (MDL 473), a long-acting rifamycin derivative.

A. Boobis, D. Davies, B. K. Park, 1986, British journal of clinical pharmacology.

Drug metabolism and drug toxicity

M. Pirmohamed, N. Kitteringham, B. K. Park, 2001, InflammoPharmacology.

Idiosyncratic Drug Reactions

M. Pirmohamed, B. K. Park, S. Madden, 1996 .

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

M. Pirmohamed, B. K. Park, D. Naisbitt, 2012, Genome Medicine.

Drug-Specific T Cells in An HIV-Positive Patient with Nevirapine-Induced Hepatitis

M. Pirmohamed, B. K. Park, D. Naisbitt, 2005, Antiviral Therapy.

TNF-α promoter region gene polymorphisms in HIV-positive patients with lipodystrophy

M. Pirmohamed, B. K. Park, A. Alfirevic, 2002 .

Toxicogenetics in drug development.

M. Pirmohamed, B. K. Park, B. Park, 2001, Toxicology letters.

The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

B. K. Park, S. Ward, P. O’Neill, 1996, Biochemical pharmacology.

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

Yongxiang Fang, A. Odermatt, N. Kitteringham, 2015, Kidney international.

Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.

M. Pirmohamed, A. Breckenridge, D. Chadwick, 1991, British journal of clinical pharmacology.

An investigation of the role of metabolism in dapsone-induced methaemoglobinaemia using a two compartment in vitro test system.

B. K. Park, M. Coleman, M. Tingle, 1990, British journal of clinical pharmacology.

Bioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues.

N. Kitteringham, B. K. Park, M. Coleman, 1990, British journal of clinical pharmacology.

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients.

M. Pirmohamed, A. Marson, B. K. Park, 2017, Chemical research in toxicology.

Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi*

M. Chamberlain, C. Wolf, N. Kitteringham, 2003, Journal of Biological Chemistry.

Characterization of drug-specific T cells in lamotrigine hypersensitivity.

M. Pirmohamed, D. Chadwick, C. A. Gibney, 2003, The Journal of allergy and clinical immunology.

Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions

B. K. Park, D. Naisbitt, A. Sullivan, 2018, Expert opinion on drug metabolism & toxicology.

Human leukocyte antigen (HLA)‐B*57:01‐restricted activation of drug‐specific T cells provides the immunological basis for flucloxacillin‐induced liver injury

M. Pirmohamed, Andrew Gibson, B. K. Park, 2013, Hepatology.

Activation of T cells by carbamazepine and carbamazepine metabolites.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2006, The Journal of allergy and clinical immunology.

TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy.

M. Pirmohamed, B. K. Park, A. Alfirevic, 2002, AIDS.

An Investigation into the Haematological Toxicity of Structural Analogues of Dapsone In‐vivo and In‐vitro

B. K. Park, M. Coleman, M. Tingle, 1991, The Journal of pharmacy and pharmacology.

Vesicular stomatitis virus infection induces a nuclear DNA-binding factor specific for the interferon-stimulated response element

J. Coligan, Y. Kanno, K. Ozato, 1995, Journal of virology.

interferon-stimulated response element . nuclear DNA-binding factor specific for the Vesicular stomatitis virus infection induces a

J. Coligan, Y. Kanno, K. Ozato, 1995 .

Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.

C. Wolf, N. Kitteringham, B. K. Park, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors.

Munir Pirmohamed, Steven Lane, Leon Aarons, 2012, British journal of clinical pharmacology.

Comparison of Milk Composition and Blood Metabolites Between High and Low Milk Producing Cows

E. Kwon, B. K. Park, H. J. Leè, 2005 .

Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells

A. Pettitt, F. Falciani, N. Kitteringham, 2021, Scientific Reports.

Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene.

L. Lian, N. Kitteringham, B. K. Park, 2007, Biochimica et biophysica acta.

T cell responses to drugs and drug metabolites.

B. K. Park, D. Naisbitt, C. Earnshaw, 2014, Experientia supplementum.

A preovulatory rise of dehydroepiandrosterone in the mare measured by radioimmunoassay.

B. K. Park, P. Rowe, P. Dean, 1976, Journal of steroid biochemistry.

Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis.

J. Dear, B. K. Park, C. Goldring, 2014, British journal of clinical pharmacology.

Safety biomarkers for drug-induced liver injury – current status and future perspectives

P. Watkins, B. K. Park, D. Antoine, 2014 .

Are we closer to finding biomarkers for identifying acute drug-induced liver injury?

B. K. Park, C. Goldring, D. Antoine, 2013, Biomarkers in medicine.

Problems of anticoagulation with warfarin in hyperthyroidism.

A. Toft, B. K. Park, S. Cholerton, 1986, The Quarterly journal of medicine.

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

Andreas Luch, Thomas Rustemeyer, Andrea Cavani, 2010, Cellular and Molecular Life Sciences.

Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells.

B. K. Park, D. Naisbitt, N. Humphreys, 2005, Toxicology.

Lack of enzyme induction with oxcarbazepine (600 mg daily) in healthy subjects.

B. K. Park, M. Brodie, G. Beastall, 1991, British journal of clinical pharmacology.

Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1997, Drug metabolism and disposition: the biological fate of chemicals.

LC determination of carbamazepine in murine brain.

M. Pirmohamed, B. K. Park, A. Owen, 2001, Journal of pharmaceutical and biomedical analysis.

Characterization of Clozapine-Responsive Human T Cells

M. Pirmohamed, B. K. Park, D. Naisbitt, 2020, The Journal of Immunology.

Lack association between schizophrenia and the CYP2D6 gene polymorphisms.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1996, American journal of medical genetics.

J. Dear, B. K. Park, C. Goldring, 2012 .

The effect of preincubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes.

B. K. Park, M. Coleman, M. Tingle, 1991, British Journal of Clinical Pharmacology.

Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4-hydroxycoumarins.

A. Breckenridge, B. K. Park, F. Preston, 1986, British journal of clinical pharmacology.

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus

D. Tuveson, I. Jacobs, U. Menon, 2015, Clinical Cancer Research.

Inhibition of dapsone-induced methaemoglobinaemia in the rat.

M. J. Winn, A. Breckenridge, B. K. Park, 1990, Biochemical pharmacology.

The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.

B. K. Park, D. Back, J. Maggs, 1987, British journal of clinical pharmacology.

Inhibition of Dapsone‐Induced Methaemoglobinaemia by Cimetidine in the Rat During Chronic Dapsone Administration

B. K. Park, M. Coleman, M. Tingle, 1991, The Journal of pharmacy and pharmacology.

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

N. Kitteringham, B. K. Park, C. Goldring, 2014, Journal of proteomics.

New Approaches to Investigate Drug-Induced Hypersensitivity.

M. Pirmohamed, Andrew Gibson, A. Norris, 2017, Chemical research in toxicology.

Quinoline analogues of ortho-quinodimethane

B. K. Park, P. O’Neill, R. C. Storr, 1995 .

The relationship between inhibition of vitamin K1 2,3-epoxide reductase and reduction of clotting factor activity with warfarin.

A. Breckenridge, B. K. Park, C. Hay, 1988, British journal of clinical pharmacology.

Vitamin K1metabolism inrelation topharmacodynamic response inanticoagulated patients

A. Breckenridge, B. K. Park, S. Cholerton, 1985 .

Plasma disposition of vitamin K1 in relation to anticoagulant poisoning.

A. Breckenridge, B. K. Park, A. Scott, 1984, British journal of clinical pharmacology.

Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.

M. Pirmohamed, D. Hughes, B. K. Park, 2004, Pharmacogenetics.

Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.

Dominic P. Williams, M. Pirmohamed, B. K. Park, 2003, Chemical research in toxicology.

Selective Haptenation of Cellular or Extracellular Protein by Chemical Allergens: Association with Cytokine Polarization

N. Kitteringham, B. K. Park, D. Naisbitt, 2005 .

New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity

M. Pirmohamed, B. K. Park, D. Ostrov, 2015, The Journal of allergy and clinical immunology.

Adverse drug reactions: back to the future.

M. Pirmohamed, B. K. Park, B. Park, 2003, British journal of clinical pharmacology.

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.

Paul J Thornalley, Masayuki Yamamoto, N. Kitteringham, 2012, The Biochemical journal.

Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide

B. K. Park, D. Back, H. Mönig, 2004, European Journal of Clinical Pharmacology.

Evidence for metabolic cleavage of a PEGylated protein in vivo using multiple analytical methodologies.

L. Lian, N. Kitteringham, B. K. Park, 2012, Molecular pharmaceutics.

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics

Masayuki Yamamoto, J. Hayes, N. Kitteringham, 2012, Pharmacological reports : PR.

Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts.

I. White, B. K. Park, J. Maggs, 2000, Carcinogenesis.

TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.

M. Pirmohamed, B. K. Park, D. Antoine, 2018, Journal of hepatology.

Characterisation of healthy donor-derived T-cell responses specific to telaprevir

M. Monshouwer, B. K. Park, Andrew Gibson, 2018 .

Role of bioactivation in drug-induced hypersensitivity reactions

B. K. Park, D. Naisbitt, Joseph P. Sanderson, 2006, The AAPS Journal.

High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.

Dominic P. Williams, A. Kipar, N. Kitteringham, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

S. Parapini, D. Taramelli, C. Davis, 2009, Journal of medicinal chemistry.

Dextromethorphan alters the reinforcing effect of cocaine in the rat.

B. K. Park, H. Kim, W. Jhoo, 1997, Methods and Findings in Experimental and Clinical Pharmacology.

Structural basis for the haemotoxicity of dapsone: the importance of the sulphonyl group.

J. Dearden, M. Cronin, B. K. Park, 1997, Toxicology.

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

Dave T. Gerrard, L. Sundstrom, N. Hanley, 2013, Hepatology.

Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.

N. Hanley, N. Kitteringham, B. K. Park, 2010, Stem cell research.

The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death.

Amy E. Chadwick, M. Monshouwer, B. K. Park, 2015, Toxicology in vitro : an international journal published in association with BIBRA.

The utility of HepG 2 cells to identify direct mitochondrial dysfunction in the absence of cell

Amy E. Chadwick, M. Monshouwer, B. K. Park, 2015 .

Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype.

M. Pirmohamed, D. Smith, N. Kitteringham, 1998, Pharmacogenetics.

Lipodystrophy in Patients with HIV-1 Infection: Effect of Stopping Protease Inhibitors on Tnf-α and Tnf-Receptor Levels, and on Metabolic Parameters

M. Pirmohamed, W. Fraser, B. K. Park, 2004, Antiviral therapy.

Reporting of adverse drug reactions by nurses

M. Pirmohamed, T. Walley, A. Breckenridge, 2003, The Lancet.

A study of factors which determine the pharmacological response to vitamin K in coumarin anticoagulated rabbits.

B. K. Park, B. Haynes, J. A. Hart, 1984, Biochemical pharmacology.

A study of the effect of anticoagulants on [3H]vitamin K1 metabolism and prothrombin complex activity in the rabbit.

A. Breckenridge, B. K. Park, M. Serlin, 1979, Biochemical pharmacology.

Roles of Nrf2 in drug and chemical toxicity

B. K. Park, I. Copple, James Murray, 2016 .

Antibacterial activity in serum and urine following oral administration in man of DL473 (a cyclopentyl derivative of rifampicin) [proceedings].

B. K. Park, N. Pearson, A. H. Short, 1978, British journal of clinical pharmacology.

Toxicological Consequences of Drug–Drug Interactions

Dominic P. Williams, B. K. Park, D. Antoine, 2010 .

Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements.

M. Pirmohamed, B. K. Park, C. Goldring, 2006, British journal of clinical pharmacology.

A comparison of vitamin K antagonism by warfarin, difenacoum and brodifacoum in the rabbit.

B. K. Park, J. Leck, B. Park, 1982, Biochemical pharmacology.

A comparative study of the effects of warfarin and brodifacoum on the relationship between vitamin K1 metabolism and clotting factor activity in warfarin-susceptible and warfarin-resistant rats.

B. K. Park, J. Leck, 1981, Biochemical Pharmacology.

The dose-dependent effect of warfarin on vitamin K1 metabolism and clotting factor synthesis in the rabbit.

A. Breckenridge, B. K. Park, J. Leck, 1980, Biochemical Pharmacology.

Pharmacokinetics and bioavailability of cefquinome in rabbits following intravenous and intramuscular administration.

B. K. Park, I. Song, H. Yun, 2011, Journal of veterinary pharmacology and therapeutics.

Carbamazepine is not a substrate for P-glycoprotein.

M. Pirmohamed, D. Chadwick, B. K. Park, 2001, British journal of clinical pharmacology.

In vitro metabolism of dexamethasone (DEX) in human liver and kidney: the involvement of CYP3A4 and CYP17 (17,20 LYASE) and molecular modelling studies.

D. Lewis, H. Kroemer, B. K. Park, 1997, Biochemical pharmacology.

Cortisol metabolism by human liver in vitro—IV. Metabolism of 9α-fluorocortisol by human liver microsomes and cytosol

B. K. Park, D. Back, J. Maggs, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Haloarene derivatives of carbamazepine with reduced bioactivation liabilities: 2-monohalo and 2,8-dihalo derivatives.

Dominic P. Williams, B. K. Park, L. Parry, 2012, Journal of medicinal chemistry.

The enzyme inducing effect of rifampicin in the rhesus monkey and its lack of interaction with oral contraceptive steroids.

A. Breckenridge, B. K. Park, D. Back, 1982, Contraception.

Drug-protein conjugates--VIII. The metabolic fate of the dinitrophenyl hapten conjugated to albumin.

N. Kitteringham, B. K. Park, J. Maggs, 1985, Biochemical pharmacology.

The measurement of oestrone, equilin and dehydroepiandrosterone in the peripheral plasma of pregnant pony mares by radioimmunoassay.

B. K. Park, T. Rance, 1978, Journal of Steroid Biochemistry.

Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans.

J. Ashby, B. K. Park, J. Maggs, 2001, The Journal of pharmacology and experimental therapeutics.

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes.

Dominic P. Williams, W. Hillen, C. Berens, 2006, American journal of physiology. Cell physiology.

Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury

Jan Snoeys, Michael J Liguori, Richard J Weaver, 2017, Expert opinion on drug metabolism & toxicology.

Optimal dose identification: predicting a safe dose in man from animal studies

M. Pirmohamed, I. White, N. Kitteringham, 2001 .

Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats.

Alison J. Foster, Dominic P. Williams, A. Czich, 2016, Toxicology letters.

Polymorphisms in the TNF-alpha and TNF-receptor genes in patients with coronary artery disease.

M. Pirmohamed, B. K. Park, R. Allen, 2001, European journal of clinical investigation.

Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency

Dominic P. Williams, M. Pirmohamed, A. Breckenridge, 1996, AIDS.

Corrections

M. Pirmohamed, B. K. Park, Andrew Gibson, 2008, The Lancet Neurology.

Synthesis of a protein conjugate of 16α-hydroxypregnenolone

B. K. Park, P. Dean, 1976 .

An immunochemical study of the hapten formed from ethynyloestradiol and guinea pig liver microsomes.

B. K. Park, A. Whittaker, 1978, FEBS letters.

Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling*

L. Djouhri, S. Sethu, N. Kitteringham, 2013, The Journal of Biological Chemistry.

Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts.

B. K. Park, D. Naisbitt, R. Jenkins, 2017, Chemical research in toxicology.

Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2003, Journal of HIV therapy.

Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization.

N. Kitteringham, B. K. Park, D. Naisbitt, 2005, Chemical research in toxicology.

Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether.

B. K. Park, S. Ward, P. O’Neill, 1999, Journal of medicinal chemistry.

Dose‐linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children

D. Tibboel, B. K. Park, C. Knibbe, 2019, Archives of Disease in Childhood.

Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.

Dominic P. Williams, N. Kitteringham, B. K. Park, 2008, Toxicology.

Drug protein conjugates--VI. Role of glutathione in the metabolism of captopril and captopril plasma protein conjugates.

A. Breckenridge, B. K. Park, J. Yeung, 1983, Biochemical pharmacology.

Effect of inhibition of glutathione synthesis on the metabolism and protein conjugation of [14C]captopril in the rat.

B. K. Park, J. Yeung, 1989, Biochemical Pharmacology.

Drug-protein conjugates--IV. The effect of acute renal failure on the disposition of [14C]captopril in the rat.

A. Breckenridge, B. K. Park, J. Yeung, 1983, Biochemical pharmacology.

Drug protein conjugates--I. A study of the covalent binding of [14C]captopril to plasma proteins in the rat.

A. Breckenridge, B. K. Park, P. Grabowski, 1982, Biochemical pharmacology.

The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1999, Pharmacogenetics.

Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials

B. van de Water, B. K. Park, B. Herpers, 2012, Molecular medicine.

Characterization of the T-Cell Response in a Patient with Phenindione Hypersensitivity

M. Pirmohamed, B. K. Park, D. Naisbitt, 2005, Journal of Pharmacology and Experimental Therapeutics.

Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications.

M. Pirmohamed, G. Tucker, N. Kitteringham, 2003, British journal of clinical pharmacology.

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin.

B. K. Park, S. Ward, P. O’Neill, 1996, Journal of medicinal chemistry.

A mechanistic investigation into the irreversible protein binding and antigenicity of p-phenylenediamine.

N. Kitteringham, B. K. Park, D. Naisbitt, 2009, Chemical research in toxicology.

Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: implications for hapten formation.

B. K. Park, D. Naisbitt, R. Jenkins, 2009, Chemical research in toxicology.

Influence of glutathione conjugation on the immunogenicity of dinitrophenyl derivatives in the rat.

N. Kitteringham, B. K. Park, J. Clarke, 1990, International archives of allergy and applied immunology.

Species variation in the bioactivation of tacrine by hepatic microsomes.

B. K. Park, S. Madden, T. Woolf, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis.

M. Pirmohamed, A. Breckenridge, B. K. Park, 1993, British journal of rheumatology.

Hepatic necrosis and glutathione depletion in captopril-treated mice.

T. Helliwell, B. K. Park, J. H. Yeung, 1985, British journal of experimental pathology.

The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.

B. K. Park, S. Ward, P. O’Neill, 1994, Journal of medicinal chemistry.

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011, The Journal of allergy and clinical immunology.

HLA DRB1*15:01-DQB1*06:02-restricted human CD4+ T-cells are selectively activated with amoxicillin-peptide adducts.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction

B. K. Park, P. Murray, Lauren Scarfe, 2019, Stem cells international.

Development of an imaging toolbox to assess the therapeutic potential and biodistribution of macrophages in a mouse model of multiple organ dysfunction

B. K. Park, P. Murray, N. Brillant, 2018, bioRxiv.

Food , drug , insect sting allergy , and anaphylaxis Stimulation of human T cells with sulfonamides and sulfonamide metabolites

B. K. Park, D. Naisbitt, W. Pichler, 2022 .

Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin.

B. K. Park, D. Naisbitt, J. Maggs, 2015, Chemical research in toxicology.

Exosomal Transport of Hepatocyte‐Derived Drug‐Modified Proteins to the Immune System

N. Kitteringham, B. K. Park, C. Goldring, 2019, Hepatology.

Synthetic strategies to lower affinity for CYP2D6

D. Smith, B. K. Park, B. Jones, 1997, European journal of drug metabolism and pharmacokinetics.

The biliary and urinary metabolites of [3H]17 alpha-ethynylestradiol in women.

A. Breckenridge, B. K. Park, J. Maggs, 1983, Xenobiotica; the fate of foreign compounds in biological systems.

Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements

N. Kitteringham, B. K. Park, C. Goldring, 2006, Journal of Experimental Biology.

Relative and absolute quantitative expression profiling of cytochromes P450 using isotope‐coded affinity tags

Rod B. Watson, Dominic P. Williams, N. Kitteringham, 2006, Proteomics.

Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.

B. K. Park, S. Ward, P. O’Neill, 1997, Journal of medicinal chemistry.

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

Min Wei Wong, Emma L. Wilkinson, J. Sidaway, 2018, Archives of Toxicology.

Development and optimisation of a suitable method to generate soluble recombinant high mobility group box 1 protein

Dominic P. Williams, L. Lian, B. K. Park, 2011 .

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2013, Journal of Allergy and Clinical Immunology.

The effect of fluorine substitution on the antimalarial activity of tebuquine

B. K. Park, S. Ward, P. O’Neill, 1996 .

MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility.

C. Rubbi, B. K. Park, R. Jenkins, 2011, Carcinogenesis.

Measurement of the urinary biomarker KIM-1 identifies the potential for aminoglycoside-induced nephrotoxicity in premature neonates

M. Pirmohamed, J. Bonventre, B. K. Park, 2011 .

The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse.

B. K. Park, S. Ward, P. O’Neill, 1995, The Journal of pharmacology and experimental therapeutics.

Determination of human hepatic cytochrome P4501A2 activity in vitro use of tacrine as an isoenzyme-specific probe.

R J Edwards, R. Edwards, D. Davies, 1995, Drug metabolism and disposition: the biological fate of chemicals.

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

Eithne Costello, D. Palmer, N. Kitteringham, 2018, Oncotarget.

Analytical methodologies for determining the metabolism and disposition of PEGylated biopharmaceuticals

L. Lian, N. Kitteringham, B. K. Park, 2011 .

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB☆

N. Kitteringham, B. K. Park, C. Goldring, 2010, Biochemical pharmacology.

Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening

B. K. Park, C. Goldring, I. Copple, 2021, Hepatology.

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Yongxiang Fang, L. Rainbow, J. Sutherland, 2018, Archives of Toxicology.