D. Wells

发表

Preimplantation genetic diagnosis for single gene disorders: experience with five single gene disorders

C. Rodeck, P. Abou-Sleiman, J. Harper, 2002, Prenatal diagnosis.

Preimplantation genetic diagnosis: applications for molecular medicine.

D. Wells, J. Delhanty, 2001, Trends in molecular medicine.

Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplification

D. Wells, J. Sherlock, 1998, Prenatal diagnosis.

Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

K. Niakan, A. Mccarthy, D. Wells, 2020, Proceedings of the National Academy of Sciences.

First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.

K. Hirschhorn, B. Levy, D. Wells, 2002 .

A successful strategy for Preimplantation Genetic Diagnosis of beta-thalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR.

D. Wells, W. Piyamongkol, T. Tongsong, 2006, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

Live births following Karyomapping of human blastocysts: experience from clinical application of the method.

D. Wells, S. Munné, M. Konstantinidis, 2015, Reproductive biomedicine online.

Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization.

D. Griffin, D. Wells, J. Grifo, 2013, Fertility and sterility.

Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.

B. Ata, L. Gianaroli, D. Wells, 2012, Fertility and sterility.

Embryo aneuploidy and the role of morphological and genetic screening.

D. Wells, 2010, Reproductive biomedicine online.

Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation rates.

Jacques Cohen, D. Wells, S. Munné, 2007, Fertility and sterility.

Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization

D. Griffin, D. Wells, J. Grifo, 2014 .

Successful Live Birth following Preimplantation Genetic Diagnosis for Phenylketonuria in Day 3 Embryos by Specific Mutation Analysis and Elective Single Embryo Transfer.

D. Wells, G. Trew, S. Lavery, 2013, JIMD reports.

Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children

Iain G. Johnston, I. Johnston, D. Wells, 2016, Biochemical Society transactions.

Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

I. Miguel-Escalada, D. Wells, N. Costa-Borges, 2020, eLife.

Global multicenter randomized controlled trial comparing single embryo transfer with embryo selected by preimplantation genetic screening using next-generation sequencing versus morphologic assessment

D. Wells, S. Willman, S. Munné, 2017 .

Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.

D. Wells, S. Munné, 2017, Fertility and sterility.

Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues

E. Thomas, D. Wells, Kate E Stanley, 2020, Fertility and Sterility.

Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours.

P. Radice, M. Pierotti, S. Pilotti, 1998, British Journal of Cancer.

Use of real-time polymerase chain reaction to measure gene expression in single cells.

D. Wells, 2007, Methods in Molecular Medicine.

Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study

D. Wells, J. Grifo, S. Munné, 2017, Human reproduction.

First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.

K. Hirschhorn, B. Levy, D. Wells, 2002, Fertility and sterility.

Clinical application of a protocol based on universal next-generation sequencing for the diagnosis of beta-thalassaemia and sickle cell anaemia in preimplantation embryos.

D. Wells, N. Kubikova, J. Sarasa, 2018, Reproductive biomedicine online.

The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies

D. Wells, S. Munné, E. Fragouli, 2018, Human reproduction update.

Human Embryonic Aneuploidy

D. Wells, E. Fragouli, 2014 .

Aneuploidy in the Human Blastocyst

D. Wells, E. Fragouli, 2011, Cytogenetic and Genome Research.

Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation.

D. Wells, A. Gordon, T. Griffiths, 2011, Human reproduction.

Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality.

D. Wells, C. Alviggi, R. Pivonello, 2016, Reproductive biomedicine online.

Preventing transmission of maternally inherited mitochondrial DNA diseases

D. Wells, P. Oakeshott, J. Poulton, 2009, BMJ : British Medical Journal.

Erratum: Genome editing reveals a role for OCT4 in human embryogenesis

K. Niakan, J. Kleinjung, Jin-Soo Kim, 2017, Nature.

The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome.

D. Wells, Zhongwei Huang, 2010, Molecular human reproduction.

Increased susceptibility to maternal aneuploidy demonstrated by comparative genomic hybridization analysis of human MII oocytes and first polar bodies

J. Mills, D. Wells, J. Delhanty, 2006, Cytogenetic and Genome Research.

The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility.

D. Wells, M. Lalioti, E. Fragouli, 2014, Human reproduction update.

Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy.

P. Patrizio, U. Kayisli, D. Wells, 2012, Human reproduction.

Development of a novel synthetic oligopeptide for the detection of DNA damage in human spermatozoa.

G. Pieczenik, D. Wells, J. Cohen, 2012, Human reproduction.

Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential

F. Kokocinski, F. Kaper, Jacques Cohen, 2015, PLoS genetics.

Molecular aspects of follicular development

D. Wells, Zhongwei Huang, 2011 .

Preimplantation genetic diagnosis: an overview and recent advances

D. Wells, P. Serhal, S. SenGupta, 2016 .

Preimplantation genetic diagnosis for infertility

D. Wells, J. Lewin, 2017 .

Continuing to deliver: the evidence base for pre-implantation genetic screening

Robert E. Anderson, D. Griffin, L. Gianaroli, 2017, British Medical Journal.

Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.

Jacques Cohen, D. Wells, Xuezhong Zheng, 2016, Reproductive biomedicine online.

Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases

J. Simpson, J. Harper, D. Wells, 2016, Prenatal diagnosis.

Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders.

D. Griffin, A. Thornhill, D. Wells, 2014, Reproductive biomedicine online.

Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology.

C. Giménez, C. Arjona, D. Wells, 2015, Reproductive biomedicine online.

Clinical utilisation of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation

Jenny C. Taylor, D. Wells, K. Kaur, 2014, Journal of Medical Genetics.

ESHRE survey results and good practice 1 recommendations on Chromosomal 2 Mosaicism 3

J. Vermeesch, C. Rubio, A. Capalbo, 2022 .

FIRST REGISTERED PILOT TRIAL TO VALIDATE THE SAFETY AND EFFECTIVENESS OF MATERNAL SPINDLE TRANSFER TO OVERCOME INFERTILITY ASSOCIATED WITH POOR OOCYTE QUALITY

D. Wells, D. Ziegler, N. Vlahos, 2020 .

Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.

A. Chavez-Badiola, D. Wells, Z. Merhi, 2017, Reproductive biomedicine online.

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

Douglass M. Turnbull, Kathy K. Niakan, Elpida Fragouli, 2016, Nature.

Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial.

H. R. Craig, L. Wilton, D. Wells, 2019, Fertility and sterility.

Clinical application of comprehensive chromosomal screening at the blastocyst stage.

Elpida Fragouli, D. Wells, Dagan Wells, 2010, Fertility and sterility.

ESHRE survey results and good practice recommendations on managing chromosomal mosaicism

J. Vermeesch, C. Rubio, A. Capalbo, 2022, Human reproduction open.

Clinical application of sequencing-based methods for parallel preimplantation genetic testing for mitochondrial DNA disease and aneuploidy.

D. Wells, J. Poulton, J. Grifo, 2021, Fertility and sterility.

Therapeutic treatments of mtDNA diseases at the earliest stages of human development.

D. Wells, F. Meirelles, J. Poulton, 2011, Mitochondrion.

Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them

D. Wells, F. Meirelles, J. Poulton, 2010, PLoS genetics.

Mitochondrial DNA Assessment to Determine Oocyte and Embryo Viability

D. Wells, E. Fragouli, 2015, Seminars in Reproductive Medicine.

Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.

D. Wells, D. Hurd, M. Paolucci, 2014, Fertility and sterility.

Genome-wide karyomapping accurately identifies the inheritance of single-gene defects in human preimplantation embryos in vitro

Alex J. Bladon, A. Paulussen, J. Dreesen, 2014, Genetics in Medicine.

Jacques Cohen, N. Steuerwald, D. Wells, 2007, Reproductive biomedicine online.

Live Birth Derived From Oocyte Spindle Transfer to Prevent Mitochondrial Disease

A. Chavez-Badiola, D. Wells, Z. Merhi, 2017 .

Non-invasive preimplantation genetic testing (niPGT): the next revolution in reproductive genetics?

D. Wells, Megan Leaver, 2019, Human reproduction update.

Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: implications for preimplantation genetic diagnosis.

J. Harper, D. Wells, W. Piyamongkol, 2003, Molecular human reproduction.

Increased numbers of DNA-damaged spermatozoa in samples presenting an elevated rate of numerical chromosome abnormalities.

D. Wells, M. Enciso, S. Alfarawati, 2013, Human reproduction.

Embryos of Robertsonian Translocation Carriers Exhibit a Mitotic Interchromosomal Effect That Enhances Genetic Instability during Early Development

D. Wells, P. Colls, E. Fragouli, 2012, PLoS genetics.

Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes.

D. Wells, J. Egozcue, J. Navarro, 2004, Human reproduction.

Aneuploidy 12 in a Robertsonian (13;14) carrier: Case report.

D. Wells, J. Navarro, J. Benet, 2005, Human reproduction.

Preimplantation genetic diagnosis

D. Wells, S. Munné, 2002, Current opinion in obstetrics & gynecology.

The origin and impact of embryonic aneuploidy

D. Wells, M. Enciso, J. Sarasa, 2013, Human Genetics.

Preimplantation Genetic Diagnosis of Inherited Cancer: Familial Adenomatous Polyposis Coli

A. Ao, D. Wells, J. Delhanty, 1998, Journal of Assisted Reproduction and Genetics.

Chromosome Abnormalities in the Human Oocyte

D. Wells, J. Delhanty, E. Fragouli, 2011, Cytogenetic and Genome Research.

The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender.

D. Wells, P. Colls, J. Stevens, 2011, Fertility and sterility.

Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.

Jacques Cohen, D. Wells, S. Munné, 2010, Fertility and sterility.

The role of preimplantation genetic diagnosis in diagnosing embryo aneuploidy

D. Wells, S. Munné, C. Howles, 2009, Current opinion in obstetrics & gynecology.

Genome editing reveals a role for OCT4 in human embryogenesis

Daesik Kim, Ludovic Vallier, Jens Kleinjung, 2017, Nature.

Cytogenetics in reproductive medicine: the contribution of comparative genomic hybridization (CGH).

B. Levy, D. Wells, 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

Clinical experience with preimplantation diagnosis of sex by dual fluorescent in situ hybridization

L. Wilton, J. Harper, A. Ao, 1994, Journal of Assisted Reproduction and Genetics.

The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

K. Niakan, A. Mccarthy, D. Wells, 2020, Nature Communications.

BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases.

A. Whittemore, B. Ponder, P. Pharoah, 2003, Cancer research.

BRCA 1 / 2 Mutation Status Influences Somatic Genetic Progression in Inherited and Sporadic Epithelial Ovarian Cancer Cases 1

A. Whittemore, B. Ponder, P. Pharoah, 2003 .

Future genetic and other technologies for assessing embryos

D. Wells, 2007 .

Recent scientific developments in assisted reproduction

Jacques Cohen, D. Wells, J. Stachecki, 2005 .

Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development.

N. Steuerwald, A. Thornhill, D. Wells, 2005, Human reproduction.

Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy

S. Bristow, D. Wells, J. Delhanty, 2016, Human Genetics.

Textbook of clinical embryology

D. Wells, K. Coward, 2013 .

Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.

B. Heindryckx, D. Wells, P. De Sutter, 2012, Fertility and sterility.

Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in vitro fertilization cycles.

W. Kuczyński, D. Wells, Celina Cybulska, 2015, Fertility and sterility.

Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.

Santiago Munné, D. Wells, Dagan Wells, 2011, Fertility and sterility.

The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.

J. Vermeesch, M. Meseguer, C. Simón, 2016, Molecular human reproduction.

Genetic alterations in gastric cancers from British patients.

I. Talbot, D. Wells, J. Delhanty, 2001, Cancer genetics and cytogenetics.

Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.

D. Wells, J. Grifo, P. Colls, 2016, Fertility and sterility.

Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid–aneuploid blastocysts

D. Wells, A. Borini, N. Tarozzi, 2017, Human Genetics.

Preimplantation genetic diagnostic protocols for α‐ and β‐thalassaemias using multiplex fluorescent PCR

J. Harper, D. Wells, W. Piyamongkol, 2001, Prenatal diagnosis.

A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR

J. Harper, D. Wells, W. Piyamongkol, 2001, Prenatal diagnosis.

A successful strategy for preimplantation diagnosis of medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency

J. Harper, D. Wells, A. Ioulianos, 2000, Prenatal diagnosis.

Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy

S. Bristow, D. Wells, J. Delhanty, 2016, Human Genetics.

Cumulus Cell Gene Expression in Assessment of Oocyte Quality

D. Wells, 2012 .

Validation of next-generation sequencing for comprehensive chromosome screening of embryos.

D. Wells, S. Munné, A. Coates, 2015, Reproductive biomedicine online.

Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH

D. Wells, E. Fragouli, S. Alfarawati, 2008, Molecular human reproduction.

Aneuploidy Screening for Embryo Selection

D. Wells, E. Fragouli, 2012, Seminars in Reproductive Medicine.

Mitochondrial DNA quantity as a biomarker for blastocyst implantation potential.

D. Wells, 2017, Fertility and sterility.

Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.

D. Wells, J. Grifo, S. Munné, 2017, Fertility and sterility.

Preimplantation genetic screening should be used in all in vitro fertilisation cycles in women over the age of 35 years: FOR: Optimising reproductive outcomes is cost‐effective and minimises adverse sequelae

D. Wells, P. Serhal, B. Jones, 2019, BJOG: An International Journal of Obstetrics & Gynaecology.

Karyomapping: a single centre's experience from application of methodology to ongoing pregnancy and live-birth rates.

D. Wells, P. Serhal, J. Ben-Nagi, 2017, Reproductive biomedicine online.

Metabolic imaging of human cumulus cells reveals associations among metabolic profiles of cumulus cells, patient clinical factors, and oocyte maturity.

C. Racowsky, D. Needleman, Xingbo Yang, 2021, Fertility and sterility.

Comparative Genomic Hybridization Analysis of Myoepithelial Carcinoma of the Breast

S. Lakhani, Chris Jones, V. Eusebi, 2000, Laboratory Investigation.

Advances in preimplantation genetic diagnosis.

D. Wells, Dagan Wells, 2004, European journal of obstetrics, gynecology, and reproductive biology.

Future technologies for preimplantation genetic applications

D. Wells, N. Kubikova, 2020 .

Aneuploidy and recombination in the human preimplantation embryo. Copy number variation analysis and genome-wide polymorphism genotyping.

D. Wells, P. Colls, S. Munné, 2019, Reproductive biomedicine online.

Association of abnormal morphology and altered gene expression in human preimplantation embryos.

Jacques Cohen, N. Steuerwald, A. Thornhill, 2005, Fertility and sterility.

A skewed sex ratio following blastocyst culture is a consequence of embryo grading systems that prioritise male embryos for transfer

D. Wells, E. Fragouli, S. Alfarawati, 2011, BJOG : an international journal of obstetrics and gynaecology.

Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos.

J. Simpson, D. Wells, 2014, Reproductive biomedicine online.

Single‐cell sequencing and mini‐sequencing for preimplantation genetic diagnosis

D. Wells, W. Piyamongkol, J. Sherlock, 2003, Prenatal diagnosis.

Deep impact: sequencing embryo biopsy specimens at increasing depth.

D. Wells, K. Spath, 2015, Reproductive biomedicine online.

Current and Future Preimplantation Genetic Screening (PGS) Technology: From Arrays to Next-Generation Sequencing

D. Wells, G. Harton, 2015 .

Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics.

D. Wells, 2014, Fertility and sterility.

Expression profiles of individual human oocytes using microarray technology.

Jacques Cohen, N. Steuerwald, D. Wells, 2004, Reproductive biomedicine online.

No evidence for age-related differences in mitochondrial RNA quality in the female germline

D. Wells, E. Repapi, J. Poulton, 2022, Reproduction & fertility.

How to improve IVF success rates and increase access to treatment: back to basics or more technology?

D. Wells, 2011 .

Corrigendum. Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers.

D. Wells, J. Grifo, S. Munné, 2019, Human Reproduction.

Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32

D. Hunt, S. Gayther, J. Fitzgibbon, 2004, Human Genetics.

First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome

A. Chavez-Badiola, D. Wells, Taosheng Huang, 2016 .

Polar bodies: their biological mystery and clinical meaning.

D. Wells, S. Hillier, 2011, Molecular human reproduction.

Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy: case report.

D. Wells, J. Navarro, J. Benet, 2008, Human reproduction.

O-94: Comprehensive characterization of gene expression in human oocytes and identification of perturbations associated with meiotic aneuploidy, maturation and infertile pathology

P. Patrizio, D. Wells, J. Delhanty, 2006 .

Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure.

Elpida Fragouli, Samer Alfarawati, D. Wells, 2010, Fertility and sterility.

Questions concerning the suitability of comparative genomic hybridization for preimplantation genetic diagnosis.

D. Wells, S. Munné, 2003, Fertility and sterility.

PGD protocols using multiplex fluorescent PCR.

J. Harper, D. Wells, W. Piyamongkol, 2001, Reproductive biomedicine online.

Questions about the accuracy of polar body analysis for preimplantation genetic screening.

D. Wells, E. Fragouli, 2013, Human reproduction.

Preimplantation genetic diagnosis of single-gene disorders: experience with more than 200 cycles conducted by a reference laboratory in the United States.

Jacques Cohen, D. Wells, S. Munné, 2009, Fertility and sterility.

PGD and aneuploidy screening for 24 chromosomes: advantages and disadvantages of competing platforms.

D. Wells, S. Munné, G. Harton, 2011, Reproductive biomedicine online.

Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation

D. Hunt, N. Katsanis, J. Fitzgibbon, 1996, FEBS letters.

Gene expression profiling of human oocytes at different maturational stages and after in vitro maturation.

Pasquale Patrizio, P. Patrizio, D. Wells, 2008, American journal of obstetrics and gynecology.

IDENTIFICATION OF NOVEL NON-INVASIVE BIOMARKERS OF

P. Patrizio, D. Wells, A. Borini, 2008 .

Extensive analysis of mitochondrial DNA quantity and sequence variation in human cumulus cells and assisted reproduction outcomes.

C. Racowsky, D. Needleman, D. Wells, 2021, Human reproduction.

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.

C. Deane, R. Hamer, B. Heindryckx, 2012, Human reproduction.

A Maternally Inherited Autosomal Point in Human Phospholipase C Zeta Leads to Male Infertility

C. Deane, R. Hamer, B. Heindryckx, 2012 .

The origin and impact of embryonic aneuploidy

D. Wells, M. Enciso, J. Sarasa, 2013, Human Genetics.

The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy.

Elpida Fragouli, Samer Alfarawati, D. Wells, 2011, Molecular human reproduction.

The First ongoing Pregnancy Following Comprehensive Aneuploidy Assessment Using a Combined Blastocenetesis, Cell Free DNA and Trophectoderm Biopsy Strategy

D. Wells, P. Serhal, S. SenGupta, 2019, Journal of reproduction & infertility.

The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

K. Niakan, A. Mccarthy, D. Wells, 2020, Nature Communications.

Pores for thought: preimplantation genetic testing using a nanopore-based DNA sequencer.

D. Wells, E. Fragouli, 2018, Fertility and sterility.

Mosaicism: "survival of the fittest" versus "no embryo left behind".

D. Wells, J. Grifo, S. Munné, 2016, Fertility and sterility.

Validation of blastocoele fluid aspiration for preimplantation genetic screening using array comparative genomic hybridization (aCGH)

D. Wells, M. Perloe, P. Morton, 2013 .

The blastocoel fluid as a source of DNA for preimplantation genetic diagnosis and screening

D. Wells, M. Poli, T. Child, 2013 .

next The effect of cryopreservation on the genome of gametes and embryos: Principles of embryos by genome of embryo

D. Wells, Megan Leaver, 2020 .

Characterization and quantification of proteins secreted by single human embryos prior to implantation

M. Beck, A. Ori, D. Wells, 2015, EMBO molecular medicine.

Karyomapping identifies second polar body DNA persisting to the blastocyst stage: implications for embryo biopsy.

D. Griffin, A. Capalbo, D. Wells, 2015, Reproductive biomedicine online.

Increased embryo implantation and high birth rates following comprehensive chromosomal screening of in-vitro fertilized embryos

D. Wells, S. Munné, W. Schoolcraft, 2009 .

Microarray-CGH for the assessment of aneuploidy in human polar bodies and oocytes.

D. Wells, S. Jaroudi, 2013, Methods in molecular biology.

The developmental potential of mosaic embryos

D. Wells, A. Borini, N. Tarozzi, 2015 .

First live birth in Greece after blastocyst trophectoderm biopsy and preimplantation genetic diagnosis by karyomapping

D. Wells, Davies, Mastrominas, 2018 .

Session 16: Innovations in reproductive genetics

P. Lacroute, Jenny C. Taylor, Lei Zhang, 2013 .

Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization.

D. Wells, J. Delhanty, D. Wells, 2000, Molecular human reproduction.

Use of Comparative Genomic Hybridisation (CGH) and Microarray-CGH for Preimplantation Genetic Screening

L. Wilton, D. Wells, 2013 .

Complete cytogenetic investigation of oocytes from a young cancer patient with the use of comparative genomic hybridisation reveals meiotic errors

J. Harper, D. Wells, A. Doshi, 2006, Prenatal diagnosis.

Whole‐genome Amplification

D. Wells, 2005 .

Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli.

S. Gayther, D. Wells, J. Delhanty, 1994, Human molecular genetics.

Association between spindle assembly checkpoint expression and maternal age in human oocytes.

N. Steuerwald, D. Wells, J. Cohen, 2000, Molecular human reproduction.

A method for semi-automatic grading of human blastocyst microscope images.

J A Noble, J. Noble, D. Wells, 2012, Human reproduction.

Comparative genomic hybridization reveals extensive variation among different MCF-7 cell stocks.

S. Lakhani, A. Kortenkamp, D. Wells, 2000, Cancer genetics and cytogenetics.

Recent advances and future developments in PGD

J. Harper, D. Wells, D. Wells, 1999, Prenatal diagnosis.

Karyomapping—a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome

D. Griffin, A. Thornhill, D. Wells, 2015, Journal of Assisted Reproduction and Genetics.

The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos

D. Wells, D. Wells, E. Fragouli, 2017, Human reproduction.

Comparative genomic hybridization analysis of human oocytes and polar bodies.

A. Thornhill, J. Harper, D. Wells, 2006, Human reproduction.

Current Controversies in Prenatal Diagnosis 3: Gene editing should replace embryo selection following PGD

J. Vermeesch, J. Simpson, D. Wells, 2019, Prenatal diagnosis.

Comprehensive cytogenetic analysis of the human blastocyst stage

D. Wells, S. Munné, W. Schoolcraft, 2008 .

A Novel Methodology Allows Detection of Every Chromosome in Single Blastomeres from Human Preimplantation Embryos and Reveals Aneuploidy, Mosaicism and Uniformly Normal Embryos

D. Wells, J. Delhanty, 2000 .

Germline rearrangement of MCC and APC detected by pulsed field gel electrophoresis and fluorescent in situ hybridization

S. Gayther, J. Burn, D. Wells, 1993, Annals of human genetics.

Should we use CRISPR gene editing in human embryos?

D. Keefe, K. Oktay, D. Wells, 2023, Fertility and sterility.

Correlation of loss of heterozygosity with cytogenetic analysis using G-banding and fluorescence in situ hybridization in aneuploid cultures from two human testicular germ-cell tumors.

D. Wells, D. Wells, J. Parrington, 1995, Cancer genetics and cytogenetics.

Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature.

H. Delemarre-van de Waal, P. Devroey, M. Bonduelle, 2014, Reproductive biomedicine online.

Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature.

P. Devroey, M. Bonduelle, J. Geraedts, 2014, Reproductive biomedicine online.

Transcriptomic Analysis of Cumulus and Granulosa Cells as a Marker of Embryo Viability

D. Wells, E. Fragouli, 2013 .

Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.

S. Gayther, D. Wells, J. Delhanty, 1995, Journal of medical genetics.

Aneuploidy and recombination in the human preimplantation embryo. Copy number variation analysis and genome-wide polymorphism genotyping.

D. Wells, P. Colls, S. Munné, 2019, Reproductive biomedicine online.

The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.

J. Vermeesch, M. Meseguer, C. Simón, 2016, Molecular human reproduction.

SELECTED ORAL COMMUNICATION SESSION, SESSION 58: EMBRYOLOGY – NON-INVASIVE ASSESSMENT, Wednesday 6 July 2011 10:00 – 11:45

P. Juvan, N. Frydman, R. Frydman, 2011 .

Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes

D. Wells, E. Seli, J. Franasiak, 2020, Reproductive Sciences.

First pilot study of maternal spindle transfer for the treatment of repeated in vitro fertilization failures in couples with idiopathic infertility.

I. Miguel-Escalada, S. Mitalipov, D. Wells, 2023, Fertility and sterility.

α-Thalassaemia SEA mutation

J. Harper, D. Wells, W. Piyamongkol, 2001 .