X. Bai

Mangmang Li, Changhai Ding, X. Bai, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteoblasts support megakaryopoiesis through production of interleukin-9.

Mangmang Li, G. Xiao, Changhai Ding, 2017, Blood.

Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury

Mangmang Li, X. Bai, Jing Nie, 2018, Cell Death & Disease.

Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin.

X. Bai, Jun Yang, Zhipeng Zou, 2016, Current cancer drug targets.

IKK interacts with rictor and regulates mTORC2.

Cuilan Yang, X. Bai, Jun Lin, 2013, Cellular signalling.

Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses

H. Ling, Ling Zhou, Mangmang Li, 2018, Mucosal Immunology.

MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint

G. Xiao, X. Bai, Lei Lu, 2019, Autophagy.

Rictor Is a Novel Regulator of TRAF6/TRAF3 in Osteoclasts

X. Bai, Song Xu, Yue Zhang, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

mTORC1 Inhibits NF‐κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice

B. Liu, Mangmang Li, G. Xiao, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7

G. Xiao, X. Bai, D. Cai, 2022, Annals of the Rheumatic Diseases.

mTORC2 promotes cell survival through c-Myc–dependent up-regulation of E2F1

Cuilan Yang, X. Bai, Jun Lin, 2015, The Journal of cell biology.

B‐cell‐specific‐peroxisome proliferator‐activated receptor γ deficiency augments contact hypersensitivity with impaired regulatory B cells

X. Bai, Xuan Zhou, L. Tao, 2019, Immunology.

Interleukin 9 prevents immune thrombocytopenia in mice via JAK/STAT5 signaling.

X. Bai, Yanjie He, Zhenguo Chen, 2019, Experimental cell research.

Tsc1 regulates tight junction independent of mTORC1

Ling Zhou, X. Bai, Yu Jiang, 2021, Proceedings of the National Academy of Sciences.

Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway

Ling Zhou, Hang Zheng, X. Bai, 2017, Oncotarget.

Skin chronological aging drives age-related bone loss via secretion of cystatin-A

Bin Huang, X. Bai, Qingchu Li, 2021, Nature Aging.

Endogenous n-3 Polyunsaturated Fatty Acids Attenuate T Cell-Mediated Hepatitis via Autophagy Activation

X. Bai, Daming Zuo, Zhengliang Chen, 2016, Front. Immunol..

LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions.

Xiong Cao, X. Bai, Song Xu, 2022, Cellular signalling.

Macrophages regulate the progression of osteoarthritis.

X. Bai, D. Cai, Haiyan Zhang, 2020, Osteoarthritis and cartilage.

Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC 1 signaling † Running title : Leptin accelerates heterotopic ossification

X. Bai, Xinggui Tian, X. Ao, 2017 .

Regulation of Mammalian Target of Rapamycin Complex 1 by Bcl-2 and Bcl-XL Proteins*

Huafei Zou, Gonghong Yan, X. Bai, 2013, The Journal of Biological Chemistry.

Deletion of Rheb1 in Osteocytes Leads to Osteopenia Characterized by Reduced Bone Formation and Enhanced Bone Resorption.

X. Bai, Jun Yang, P. Lai, 2022, DNA and cell biology.

DEPTOR Deficiency-Mediated mTORc1 Hyperactivation in Vascular Endothelial Cells Promotes Angiogenesis

Ling Zhou, X. Bai, Ting Li, 2018, Cellular Physiology and Biochemistry.

Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

Huiling Cao, G. Xiao, T. Cheng, 2020, Nature Communications.

Mechanical loading modulates heterotopic ossification in calcific tendinopathy through the mTORC1 signaling pathway

X. Bai, Xinggui Tian, Zhongmin Zhang, 2017, Molecular medicine reports.

UBAP2L arginine methylation by PRMT1 modulates stress granule assembly

X. Bai, Zhenguo Chen, Minyu Xie, 2019, Cell Death & Differentiation.

n-3 polyunsaturated fatty acids abrogate mTORC1/2 signaling and inhibit adrenocortical carcinoma growth in vitro and in vivo.

X. Bai, Zhenguo Chen, Yukun Wu, 2016, Oncology reports.

Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway

Mangmang Li, Bin Huang, X. Bai, 2018, Annals of the rheumatic diseases.

Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

X. Bai, D. Cai, Haiyan Zhang, 2020, Arthritis Research & Therapy.

MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway

X. Bai, D. Cai, Yuheng Lu, 2021, Cell Death & Disease.

TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury.

X. Bai, Wenqing Jiang, Song Xu, 2018, Clinical science.

Osteoarthritic infrapatellar fat pad aggravates cartilage degradation via activation of p38MAPK and ERK1/2 pathways

Changhai Ding, X. Bai, Zhaohua Zhu, 2020, Inflammation Research.

Acellular spinal cord scaffold seeded with bone marrow stromal cells protects tissue and promotes functional recovery in spinal cord‐injured rats

X. Bai, Jia Liu, Zhongmin Zhang, 2014, Journal of neuroscience research.

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Xiaoping Zhou, X. Bai, Xuhua Liu, 2021, Nature Communications.

Fast degradable citrate-based bone scaffold promotes spinal fusion.

Jian Yang, Gloria B. Kim, X. Bai, 2015, Journal of materials chemistry. B.

Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone

Mangmang Li, Bin Huang, B. Yan, 2016, Nature Communications.

Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.

X. Bai, Anling Liu, Yan Gong, 2023, Developmental cell.

Synthesis and characterization of biomimetic citrate-based biodegradable composites.

R. T. Tran, Justin L. Brown, Jian Yang, 2014, Journal of biomedical materials research. Part A.

Development of Injectable Citrate-Based Bioadhesive Bone Implants.

R. T. Tran, M. Mehdizadeh, Jian Yang, 2015, Journal of materials chemistry. B.

Bone and plasma citrate is reduced in osteoporosis.

G. Xiao, X. Bai, Xinggui Tian, 2018, Bone.

Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice

Di Chen, Huiling Cao, G. Xiao, 2020, Bone Research.

Biomaterial‐Based Metabolic Regulation in Regenerative Engineering

Jian Yang, X. Bai, Chuying Ma, 2019, Advanced science.

Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38

X. Bai, Yu Jiang, Q. Wang, 2007, Science.

Citric Acid-based Hydroxyapatite Composite Scaffolds Enhance Calvarial Regeneration

R. T. Tran, Richard T. Tran, Xiaochun Bai, 2014, Scientific Reports.

Citrate‐Based Tannin‐Bridged Bone Composites for Lumbar Fusion

Jian Yang, X. Bai, Xinggui Tian, 2020, Advanced Functional Materials.

Positive‐Feedback Regulation of Subchondral H‐Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice

Bin Huang, X. Bai, D. Xie, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives.

Jian Yang, X. Bai, D. Xie, 2019, Biomaterials.

Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation

Ling Zhou, Yifan Dai, Hang Zheng, 2016, Oncotarget.

Rictor/mTORC2 Pathway in Oocytes Regulates Folliculogenesis, and Its Inactivation Causes Premature Ovarian Failure*

Xiaochun Bai, Zhenguo Chen, Weiping Yuan, 2015, The Journal of Biological Chemistry.

Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses

H. Ling, Ling Zhou, Mangmang Li, 2018, Mucosal Immunology.

miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM.

Cuilan Yang, X. Bai, Jun Lin, 2014, Cancer research.

mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo

Yifan Dai, X. Bai, Jun Lin, 2012, Breast Cancer Research and Treatment.

Key factors in mTOR regulation

X. Bai, Yu Jiang, 2009, Cellular and Molecular Life Sciences.

Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis.

Weiping Yuan, X. Bai, Jun Lin, 2015, Endocrinology.

mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway

B. Liu, Bin Huang, X. Bai, 2015, PLoS genetics.

TPX2 Level Correlates with Hepatocellular Carcinoma Cell Proliferation, Apoptosis, and EMT

Xin-cheng Liu, Hua He, X. Bai, 2015, Digestive Diseases and Sciences.

Molecular and Cellular Pathobiology miR-483-5 p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI 1 and ALCAM

Cuilan Yang, X. Bai, Jun Lin, 2014 .

Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc

Huiling Cao, G. Xiao, Di Chen, 2022, Bone Research.

Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice

Huiling Cao, G. Xiao, X. Bai, 2021, Diabetes.

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR

G. Xiao, X. Bai, D. Cai, 2020, Aging.

Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12

X. Bai, D. Cai, Haiyan Zhang, 2019, Bone Research.

mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis.

X. Bai, D. Xie, D. Cai, 2017, Osteoarthritis and cartilage.

Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.

X. Bai, D. Cai, Yuheng Lu, 2021, Rheumatology.

A new generation of sodium chloride porogen for tissue engineering

R. T. Tran, Jian Yang, X. Bai, 2011, Biotechnology and applied biochemistry.

Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer

Hang Zheng, Cuilan Yang, X. Bai, 2012, Breast Cancer Research and Treatment.

Chondrocyte mTORC1 activation stimulates miR‐483‐5p via HDAC4 in osteoarthritis progression

Jian Yang, Changhai Ding, X. Bai, 2018, Journal of cellular physiology.

Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis.

X. Bai, Zhongmin Zhang, Liang Wang, 2014, Oncology reports.

Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively

X. Bai, P. Lai, Hai Huang, 2020, BioMed research international.

Design Strategies and Applications of Citrate-Based Biodegradable Elastomeric Polymers

R. T. Tran, Jian Yang, X. Bai, 2014 .

Enhancement of osteogenesis post‐splenectomy does not attenuate bone loss in ovariectomized rats

X. Bai, D. Cai, Chuangxin Lin, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Different Sex-Based Responses of Gut Microbiota During the Development of Hepatocellular Carcinoma in Liver-Specific Tsc1-Knockout Mice

Ting Li, Yang Li, X. Bai, 2018, Front. Microbiol..

Establishment of bovine expanded potential stem cells

F. Tang, Xuefei Gao, S. Bao, 2021, Proceedings of the National Academy of Sciences.

Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β-cells causes morphological and functional changes

X. Bai, Daoyan Pan, Jie Shen, 2020, Molecular medicine reports.

Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.

G. Xiao, X. Bai, Yu Jiang, 2021, Developmental cell.

High ratio of ω-3/ω-6 polyunsaturated fatty acids targets mTORC1 to prevent high-fat diet-induced metabolic syndrome and mitochondrial dysfunction in mice.

Zhihui Feng, X. Bai, Jiankang Liu, 2020, The Journal of nutritional biochemistry.

Activation of mTORC1 in B Lymphocytes Promotes Osteoclast Formation via Regulation of β‐Catenin and RANKL/OPG

B. Liu, Bin Huang, X. Bai, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft.

X. Bai, Jun Liu, C. Jia, 2013, Urologic oncology.

Loss of Rictor with aging in osteoblasts promotes age-related bone loss

B. Liu, Mangmang Li, X. Bai, 2016, Cell Death and Disease.

Loss of Fbxw7 in Sertoli cells impairs testis development and causes infertility in mice†

X. Bai, Zhenguo Chen, Xuemei Li, 2019, Biology of Reproduction.

IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1

Cuilan Yang, X. Bai, T. Gao, 2012, Cell Death and Differentiation.

TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42

Mangmang Li, G. Xiao, Jiake Xu, 2017, Cell Death & Differentiation.

Phospholipase C-γI Is Required for Survival in Heat Stress: Involvement of Protein Kinase C-Depertment Bel-2 Phosphorylation

X. Bai, F. Deng, S. Luo, 2002 .

A MAP Kinase Dependent Feedback Mechanism Controls Rho1 GTPase and Actin Distribution in Yeast

Gonghong Yan, X. Bai, Yu Jiang, 2009, PloS one.

Exosome Release Is Regulated by mTORC1

Lei Zheng, Anling Liu, Xiaochun Bai, 2018, Advanced science.

mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression

Z. Zhao, H. Zheng, Yifan Dai, 2014, Oncogene.

Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models

Yifan Dai, Hang Zheng, X. Bai, 2014, Cancer Prevention Research.

SPTBN1 Prevents Primary Osteoporosis by Modulating Osteoblasts Proliferation and Differentiation and Blood Vessels Formation in Bone

Hangtian Wu, X. Bai, Jie Shen, 2021, Frontiers in Cell and Developmental Biology.

Inhibition of endometrial cancer by n-3 polyunsaturated fatty acids ( PUFAs ) in preclinical models

Yifan Dai, Hang Zheng, X. Bai, 2014 .

mTOR Overactivation in Mesenchymal cells Aggravates CCl4− Induced liver Fibrosis

Ling Zhou, Hang Zheng, X. Bai, 2016, Scientific Reports.

DNMT1 is a negative regulator of osteogenesis

X. Bai, Jia Liu, Yujin Tang, 2022, Biology open.

Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis†

X. Bai, Q. Song, Zhenguo Chen, 2018, Biology of Reproduction.

UBAP2L arginine methylation by PRMT1 modulates stress granule assembly

X. Bai, Zhenguo Chen, Minyu Xie, 2019, Cell Death & Differentiation.

Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice

X. Bai, Zhongmin Zhang, Liang Wang, 2017, Journal of healthcare engineering.

Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC1 signaling

X. Bai, Xinggui Tian, X. Ao, 2018, Journal of cellular physiology.

Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor

X. Bai, Meixiong Chen, Sheng Zheng, 2021, Stem cell research & therapy.

Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway

Ling Zhou, Hang Zheng, X. Bai, 2017, Oncotarget.

Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes

Huiling Cao, G. Xiao, Di Chen, 2021, Communications biology.

NF-κB and Hsp70 are involved in the phospholipase Cγ1 signaling pathway in colorectal cancer cells

X. Bai, F. Deng, S. Luo, 2005 .

PTH(1-34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway

X. Bai, X. Zou, Aikeremujiang Muheremu, 2020, International journal of molecular medicine.

Exosome Release Delays Senescence by Disposing of Obsolete Biomolecules

X. Bai, Shiming Liu, Zhongjia Cui, 2023, Advanced science.

Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

Huiling Cao, G. Xiao, T. Cheng, 2020, Nature Communications.

Low-dose arsenic trioxide combined with aclacinomycin A synergistically enhances the cytotoxic effect on human acute myelogenous leukemia cell lines by induction of apoptosis

X. Bai, Xin He, Ziwen Guo, 2015, Leukemia & lymphoma.

Classification of Osteosarcoma Based on Immunogenomic Profiling

Wanzun Lin, X. Bai, Weifeng Xu, 2021, Frontiers in Cell and Developmental Biology.

Activation of mTORC1 in collecting ducts causes hyperkalemia.

Cuilan Yang, X. Bai, Jun Lin, 2014, Journal of the American Society of Nephrology : JASN.

Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis.

X. Bai, C. Ding, W. Han, 2018, Osteoarthritis and cartilage.

mTORC1 Activation Promotes Spermatogonial Differentiation and Causes Subfertility in Mice1

X. Bai, Zhenguo Chen, Zhipeng Zou, 2016, Biology of reproduction.

mTORC 1 Activation Promotes Spermatogonial Differentiation and Causes Subfertility in Mice 1

X. Bai, Zhenguo Chen, Zhipeng Zou, 2016 .

Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice

Bin Huang, X. Bai, D. Cai, 2017, BioMed research international.

Chondrocyte-Specific Ablation of AMPKα1 Does Not Affect Bone Development or Pathogenesis of Osteoarthritis in Mice.

X. Bai, Dadi Jin, Cheng Yang, 2016, DNA and cell biology.

mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation.

X. Bai, Yu Jiang, Dinghua Yang, 2016, Blood.

Association between proton pump inhibitors use and risk of hip fracture: A general population-based cohort study.

X. Bai, C. Zeng, G. Lei, 2020, Bone.

Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis.

X. Bai, Zhongmin Zhang, Liang Wang, 2014, Oncology reports.

Strontium ranelate, a promising disease modifying osteoarthritis drug

X. Bai, C. Ding, S. Fan, 2017, Expert opinion on investigational drugs.