S. Yamashita

发表

Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug.

K. Kawakami, Shaoling Zhang, Marina Yamamoto, 2011, Molecular pharmaceutics.

Small differences in acidic pH condition significantly affect dissolution equivalence between drug products of acidic drug salt

S. Yamashita, Tomoya Yoshikawa, Jumpei Oki, 2021 .

Effect of P-glycoprotein expression levels on the concentration-dependent permeability of drugs to the cell membrane.

S. Yamashita, T. Sakane, Y. Shirasaka, 2008, Journal of pharmaceutical sciences.

A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan.

Lawrence X. Yu, Lawrence X Yu, Marival Bermejo, 2006, Molecular pharmaceutics.

The transnasal delivery of 5-fluorouracil to the rat brain is enhanced by acetazolamide (the inhibitor of the secretion of cerebrospinal fluid).

I. Hidalgo, S. Yamashita, H. Katsumi, 2009, International journal of pharmaceutics.

Application of an In Vitro Dissolution/Permeation System to Early Screening of Oral Formulations of Poorly Soluble, Weakly Basic Drugs Containing an Acidic pH-Modifier.

M. Kataoka, S. Yamashita, Koichi Wada, 2018, Journal of pharmaceutical sciences.

Enteric-coated tablets improve oral bioavailability of DX-9065, a novel anticoagulant.

S. Yamashita, S. Sakuma, H. Kikuchi, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution/permeation system.

M. Kataoka, S. Yamashita, P. Langguth, 2009, Journal of pharmaceutical sciences.

Nasal delivery of P-gp substrates to the brain through the nose-brain pathway.

I. Hidalgo, S. Yamashita, H. Katsumi, 2011, Drug metabolism and pharmacokinetics.

Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation.

Y. Masaoka, M. Kataoka, S. Yamashita, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Challenge for oral delivery of middle-molecular drugs: Use of osmolarity-sensitive liposome as a drug carrier in the GI tract

M. Kataoka, S. Yamashita, N. Oku, 2020 .

Estimation of Michaelis-Menten constant of efflux transporter considering asymmetric permeability.

S. Yamashita, K. Sugano, Y. Shirasaka, 2011, International journal of pharmaceutics.

What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine.

T. Fujita, S. Yamashita, M. Ozawa, 2006, Drug metabolism and pharmacokinetics.

Assessment of Intestinal Availability of Various Drugs in the Oral Absorption Process Using Portal Vein-Cannulated Rats

S. Yamashita, K. Morisaki, Yoshiki Matsuda, 2012, Drug Metabolism and Disposition.

In Vitro System to Evaluate Oral Absorption of Poorly Water-Soluble Drugs: Simultaneous Analysis on Dissolution and Permeation of Drugs

Makoto Kataoka, Hitoshi Sezaki, Y. Masaoka, 2003, Pharmaceutical Research.

Biopredictive in vitro testing methods to assess intestinal drug absorption from supersaturating dosage forms

B. Hens, K. Kawakami, M. Kataoka, 2020 .

In Vitro Assessment of Supersaturation/Precipitation and Biological Membrane Permeation of Poorly Water-Soluble Drugs: A Case Study With Albendazole and Ketoconazole.

M. Kataoka, S. Yamashita, Y. Fujii, 2019, Journal of pharmaceutical sciences.

Effects of gastric pH on oral drug absorption: In vitro assessment using a dissolution/permeation system reflecting the gastric dissolution process.

M. Kataoka, S. Yamashita, S. Sakuma, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Interaction with Mixed Micelles in the Intestine Attenuates the Permeation Enhancing Potential of Alkyl-Maltosides.

B. Pedersen, M. Kataoka, S. Yamashita, 2015, Molecular pharmaceutics.

Integrating drug permeability with dissolution profile to develop IVIVC

M. Kataoka, S. Yamashita, R. Takano, 2012, Biopharmaceutics & drug disposition.

Imaging of Gastrointestinal Absorption and Biodistribution of an Orally Administered Probe Using Positron Emission Tomography in Humans

Y. Sugiyama, Y. Shigihara, S. Yamashita, 2012, Clinical pharmacology and therapeutics.

Preparation of spray-dried microparticles using Gelucire 44/14 and porous calcium silicate or spherical microcrystalline cellulose to enhance transport of water-insoluble pranlukast hemihydrate across Caco-2 monolayers

H. Okada, M. Kataoka, S. Yamashita, 2011 .

Effect of food intake on the oral absorption of poorly water-soluble drugs: in vitro assessment of drug dissolution and permeation assay system.

Y. Masaoka, M. Kataoka, S. Yamashita, 2006, Journal of pharmaceutical sciences.

Impact of NEDO project on microdosing clinical studies: toward the eIND study in Japan.

S. Yamashita, 2011, Drug metabolism and pharmacokinetics.

Impact of NEDO project on microdosing clinical studies: toward the eIND study in Japan.

S. Yamashita, 2011 .

Cross-reactivity of immunoglobulin A secreted on the nasal mucosa in mice nasally inoculated with inactivated H1N1 influenza A viruses in the presence of D-octaarginine-linked polymers.

M. Kataoka, S. Yamashita, S. Sakuma, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Cell-penetrating peptide-linked polymers as carriers for mucosal vaccine delivery.

Y. Masaoka, M. Kataoka, S. Yamashita, 2012, Molecular pharmaceutics.

Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal.

Y. Masaoka, M. Kataoka, S. Yamashita, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Investigation on the Mechanisms of Drug Permeation across the Mucosal Membrane using Electrophysiological Methods

S. Yamashita, 1993 .

Interaction of percutaneous absorption enhancer with stratum corneum of hamster cheek pouch; an electrophysiological study

S. Yamashita, T. Nadai, Toshikiro Kimura, 1992 .

Bioequivalence of Oral Drug Products in the Healthy and Special Populations: Assessment and Prediction Using a Newly Developed In Vitro System “BE Checker”

M. Kataoka, S. Yamashita, K. Matsui, 2021, Pharmaceutics.

Measurement of Drug Concentration in the Stomach After Intragastric Administration of Drug Solution to Healthy Volunteers: Analysis of Intragastric Fluid Dynamics and Drug Absorption

M. Kataoka, S. Yamashita, S. Sakuma, 2012, Pharmaceutical Research.

Characterization of gastrointestinal drug absorption in cynomolgus monkeys.

S. Yamashita, N. Suzuki, M. Hayashi, 2008, Molecular pharmaceutics.

Systematic approach to optimize a pretreatment method for ultrasensitive liquid chromatography with tandem mass spectrometry analysis of multiple target compounds in biological samples.

H. Yamazaki, M. Kataoka, S. Yamashita, 2016, Journal of separation science.

The Site-Specific Transport and Metabolism of Tacrolimus in Rat Small Intestine

G. Amidon, S. Yamashita, R. Ibuki, 2003, Journal of Pharmacology and Experimental Therapeutics.

Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates

Y. Sugiyama, Motohiro Kato, S. Yamashita, 2010, Pharmaceutical Research.

Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.

Yuichi Sugiyama, Makoto Kataoka, Hiroyuki Kusuhara, 2017, Drug metabolism and pharmacokinetics.

Species differences in the drug-drug interaction between atorvastatin and cyclosporine: In vivo study using a stable isotope-IV method in rats and dogs.

M. Kataoka, S. Yamashita, Keiko Minami, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Quantitative Analysis of the Transporter-Mediated Drug-Drug Interaction Between Atorvastatin and Rifampicin Using a Stable Isotope-IV Method.

M. Kataoka, S. Yamashita, Kazutaka Togashi, 2017, Journal of pharmaceutical sciences.

Analysis of the Complicated Nonlinear Pharmacokinetics of Orally Administered Telmisartan in Rats Using a Stable Isotope-IV Method.

M. Kataoka, S. Yamashita, Kazutaka Togashi, 2019, Journal of pharmaceutical sciences.

Scaling of in Vitro Membrane Permeability to Predict P-glycoprotein-Mediated Drug Absorption in Vivo

Y. Masaoka, M. Kataoka, S. Yamashita, 2008, Drug Metabolism and Disposition.

Evaluation of human P-glycoprotein (MDR1/ABCB1) ATPase activity assay method by comparing with in vitro transport measurements: Michaelis-Menten kinetic analysis to estimate the affinity of P-glycoprotein to drugs.

T. Ishikawa, H. Nakagawa, S. Yamashita, 2006, Biological & pharmaceutical bulletin.

An Assessment of the Oral Bioavailability of Three Ca-Channel Blockers Using a Cassette-Microdose Study: A New Strategy for Streamlining Oral Drug Development.

Yuichi Sugiyama, Makoto Kataoka, Kyoichi Ohashi, 2015, Journal of pharmaceutical sciences.

Impact of microdosing clinical study -- why necessary and how useful?

Yuichi Sugiyama, Y. Sugiyama, S. Yamashita, 2011, Advanced drug delivery reviews.

Formulation design for orally disintegrating tablets containing enteric-coated particles.

S. Yamashita, Yasunobu Okamoto, K. Okimoto, 2014, Chemical & pharmaceutical bulletin.

Absorption and Metabolism of Antioxidative Polyphenolic Compounds in Red Wine

S. Yamashita, H. Koda, T. Sakane, 2002, Annals of the New York Academy of Sciences.

Polymer-phloridzin conjugates as an anti-diabetic drug that inhibits glucose absorption through the Na+/glucose cotransporter (SGLT1) in the small intestine.

M. Akashi, T. Kida, S. Yamashita, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Expression levels of human P-glycoprotein in in vitro cell lines: correlation between mRNA and protein levels for P-glycoprotein expressed in cells.

S. Yamashita, T. Sakaeda, Y. Shirasaka, 2009, Biopharmaceutics & drug disposition.

A new interpretation of salicylic acid transport across the lipid bilayer: implications of pH-dependent but not carrier-mediated absorption from the gastrointestinal tract.

S. Yamashita, N. Oku, T. Nadai, 1998, The Journal of pharmacology and experimental therapeutics.

Peanut Agglutinin-Immobilized Fluorescent Nanospheres with Surface Poly(N-vinylacetamide) Chains as a Novel Colonoscopic Imaging Agent

L. Tang, R. Kimura, R. Hoffman, 2010 .

The structural barrier of absorptive mucosae: Site difference of the permeability of fluorescein isothiocyanate‐labelled dextran in rabbits

S. Yamashita, H. Natsume, K. Sugibayashi, 1993, Biopharmaceutics & drug disposition.

Report from the “3rd International Symposium on BA/BE of Oral Drug Products: Biopharmaceutics meets Galenics”

G. Amidon, M. Bermejo, K. Kawakami, 2020 .

Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na⁺/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake.

M. Akashi, T. Kida, Y. Masaoka, 2012, Molecular pharmaceutics.

Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(gamma-glutamic acid).

M. Akashi, T. Kida, Y. Masaoka, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Control of oral absorption of nutritional supplement using lipid-based formulations (LBFs): Application to the poorly water-soluble ingredient

M. Kataoka, S. Yamashita, H. Shibata, 2020, Journal of Drug Delivery Science and Technology.

Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity

M. Hashida, S. Yamashita, T. Nadai, 1991, The Journal of pharmacy and pharmacology.

Effect of experimental acute renal and hepatic failure on absorption of tacrolimus in rat small intestine.

G. Amidon, S. Yamashita, A. Ohike, 2004, Drug metabolism and pharmacokinetics.

Further investigations on the transport mechanism of cephalexin and ampicillin across rat jejunum.

S. Yamashita, T. Nadai, H. Sezaki, 1984, Journal of pharmacobio-dynamics.

Direct Drug Transport from the Rat Nasal Cavity to the Cerebrospinal Fluid: the Relation to the Molecular Weight of Drugs

S. Yamashita, T. Nadai, T. Sakane, 1995, The Journal of pharmacy and pharmacology.

The transport of a drug to the cerebrospinal fluid directly from the nasal cavity: the relation to the lipophilicity of the drug.

M. Hashida, S. Yamashita, T. Nadai, 1991, Chemical & pharmaceutical bulletin.

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells.

M. Kataoka, S. Yamashita, T Sakane, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Improvement of low bioavailability of a novel factor Xa inhibitor through formulation of cationic additives in its oral dosage form.

M. Akashi, S. Yamashita, S. Sakuma, 2011, International journal of pharmaceutics.

Interspecies differences in gastrointestinal physiology affecting the in vivo performance of oral pharmaceutical solid dosage forms

M. Kataoka, S. Yamashita, H. Kikuchi, 2021, Journal of Drug Delivery Science and Technology.

Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution.

M. Kataoka, S. Yamashita, K. Higashi, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Mechanistic analysis for positive and negative food effects on oral absorption of poorly soluble drugs from cyclodextrin containing formulations: Study with a mini-scale in vitro system

S. Yamashita, T. Takagi, Koichi Wada, 2022, Journal of Drug Delivery Science and Technology.

Design of supersaturable formulation of telmisartan with pH modifier: in vitro study on dissolution and precipitation

M. Kataoka, S. Yamashita, Koichi Wada, 2017, Journal of Pharmaceutical Investigation.

Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the dissociation of the drug

S. Yamashita, T. Nadai, T. Sakane, 1994, The Journal of pharmacy and pharmacology.

Direct drug transport from the nasal cavity to the cerebrospinal fluid. A new strategy for drug delivery to the brain

S. Yamashita, T. Nadai, T. Sakane, 1997 .

Transnasal delivery of 5-fluorouracil to the brain in the rat.

N. Yata, S. Yamashita, T. Sakane, 1999, Journal of drug targeting.

Characterization of Drug Transport Through Tight-Junctional Pathway in Caco-2 Monolayer: Comparison with Isolated Rat Jejunum and Colon

S. Yamashita, T. Nadai, T. Sakane, 1995, Pharmaceutical Research.

Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds

S. Yamashita, K. Yoshinari, Y. Konno, 2016, Drug Metabolism and Disposition.

Measurement of Drug Concentration in the Stomach After Intragastric Administration of Drug Solution to Healthy Volunteers: Analysis of Intragastric Fluid Dynamics and Drug Absorption

M. Kataoka, S. Yamashita, S. Sakuma, 2013, Pharmaceutical Research.

A new formulation for orally disintegrating tablets using a suspension spray-coating method.

S. Yamashita, K. Okimoto, T. Ōsawa, 2009, International journal of pharmaceutics.

Liposomal Formulation for Oral Delivery of Cyclosporine A: Usefulness as a Semisolid-Dispersion System

M. Kataoka, S. Yamashita, N. Oku, 2022, Pharmaceutical Research.

Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test

Kiyohiko Sugano, Yoshiki Hayashi, Minoru Machida, 2006, Pharmaceutical Research.

Characterizing the dissolution profiles of supersaturable salts, cocrystals, and solvates to enhance in vivo oral absorption.

M. Kataoka, S. Yamashita, Koji Shiraki, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Correlation between in vitro dissolution profiles from enteric-coated dosage forms and in vivo absorption in rats for high-solubility and high-permeability model drugs.

Y. Masaoka, M. Kataoka, S. Yamashita, 2009, Journal of pharmaceutical sciences.

Prediction of food effect by bile micelles on oral drug absorption considering free fraction in intestinal fluid.

Kiyohiko Sugano, Makoto Kataoka, M. Kataoka, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation

S. Yamashita, Y. Aso, Koji Shiraki, 2008, Pharmaceutical Research.

In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior.

G. Amidon, M. Kataoka, S. Yamashita, 2021, Molecular pharmaceutics.

The challenge of proteolytic enzymes in intestinal peptide delivery

G. Amidon, S. Wolffram, H. Merkle, 1997 .

Extent and rate of oral drug absorption in minipigs: Comparison with mice, rats and humans

S. Yamashita, Hiromichi Yoshimatsu, K. Ishii, 2020 .

Site-specific drug delivery to the middle-to-lower region of the small intestine reduces food-drug interactions that are responsible for low drug absorption in the fed state.

Y. Masaoka, M. Kataoka, S. Yamashita, 2008, Journal of pharmaceutical sciences.

Site-specific drug delivery to the middle region of the small intestine by application of enteric coating with hypromellose acetate succinate (HPMCAS).

Y. Masaoka, M. Kataoka, S. Yamashita, 2008, Journal of pharmaceutical sciences.

Characterization of enhanced intestinal permeability; electrophysiological study on the effects of diclofenac and ethylenediaminetetraacetic acid

S. Yamashita, T. Nadai, K. Nakanishi, 1985, The Journal of pharmacy and pharmacology.

A potential of peanut agglutinin-immobilized fluorescent nanospheres as a safe candidate of diagnostic drugs for colonoscopy.

J. Gore, Y. Masaoka, M. Kataoka, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vitro/in vivo biorecognition of lectin-immobilized fluorescent nanospheres for human colorectal cancer cells.

Li Tang, R. Hoffman, Y. Masaoka, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Poly(N-vinylacetamide) chains enhance lectin-induced biorecognition through the reduction of nonspecific interactions with nontargets.

Y. Masaoka, M. Kataoka, S. Yamashita, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Conjugation of poorly absorptive drugs with mucoadhesive polymers for the improvement of oral absorption of drugs.

Zheng-Rong Lu, Yanli Wang, S. Yamashita, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Effect of adjuvants on charge-selective permeability and electrical resistance of rat jejunal membrane.

S. Yamashita, T. Nadai, T. Kimura, 1990, Journal of pharmaceutical sciences.

Effects of diclofenac sodium and disodium ethylenediaminetetraacetate on electrical parameters of the mucosal membrane and their relation to the permeability enhancing effects in the rat jejunum

S. Yamashita, T. Nadai, Toshikiro Kimura, 1987, The Journal of pharmacy and pharmacology.

Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake.

M. Akashi, T. Kida, Y. Masaoka, 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

High-permeability criterion for BCS classification: segmental/pH dependent permeability considerations.

Lawrence X. Yu, G. Amidon, H. Lennernäs, 2010, Molecular pharmaceutics.

Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract.

Makoto Kataoka, Y. Masaoka, M. Kataoka, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Time-Dependent Oral Absorption Models

Gordon L. Amidon, Kazutaka Higaki, G. Amidon, 2001, Journal of Pharmacokinetics and Pharmacodynamics.

Tacrolimus is a class II low-solubility high-permeability drug: the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats.

G. Amidon, S. Yamashita, A. Ohike, 2002, Journal of pharmaceutical sciences.

Quantitative Assessment of Intestinal First-pass Metabolism of Oral Drugs Using Portal-vein Cannulated Rats

S. Yamashita, Yoshiki Matsuda, Y. Konno, 2014, Pharmaceutical Research.

Quantitative evaluation of the gastrointestinal absorption of protein into the blood and lymph circulation.

K. Watabe, S. Yamashita, T. Nadai, 1996, Biological & pharmaceutical bulletin.

Carrier-Mediated Transport of Macrolide Antimicrobial Agents Across Caco-2 Cell Monolayers

S. Yamashita, H. Sezaki, H. Saito, 2000, Pharmaceutical Research.

Construction of a Functional Transporter Analysis System Using MDR1 Knockdown Caco-2 Cells

Y. Sugiyama, K. Taira, S. Yamashita, 2005, Pharmaceutical Research.

In Vivo Assessment of the Impact of Efflux Transporter on Oral Drug Absorption Using Portal Vein–Cannulated Rats

S. Yamashita, Yoshiki Matsuda, Y. Konno, 2013, Drug Metabolism and Disposition.

Evaluation of the contribution of the nasal cavity and gastrointestinal tract to drug absorption following nasal application to rats.

Y. Masaoka, M. Kataoka, S. Yamashita, 2007, Biological & pharmaceutical bulletin.

Further improvement of orally disintegrating tablets using micronized ethylcellulose.

S. Yamashita, K. Okimoto, T. Ōsawa, 2012, International journal of pharmaceutics.

Dynamic analysis of fluid distribution in the gastrointestinal tract in rats: positron emission tomography imaging after oral administration of nonabsorbable marker, [(18)F]Deoxyfluoropoly(ethylene glycol).

Yasuyoshi Watanabe, Y. Sugiyama, Masaaki Suzuki, 2013, Molecular pharmaceutics.

Importance of Gastric Secretion and the Rapid Gastric Emptying of Ingested Water along the Lesser Curvature ("Magenstraße") in Predicting the In Vivo Performance of Liquid Oral Dosage Forms in the Fed State Using a Modeling and Simulation.

S. Yamashita, T. Takagi, A. Kambayashi, 2022, Molecular pharmaceutics.

Comparative acceptability of mini-tablets, fine granules, and liquid formulations in young children: An exploratory randomized crossover study

S. Yamashita, K. Miyazaki, Hidefumi Nakamura, 2022, Journal of Drug Delivery Science and Technology.

In vitro dissolution/permeation system to predict the oral absorption of poorly water-soluble drugs: effect of food and dose strength on it.

Makoto Kataoka, Y. Masaoka, M. Kataoka, 2011, Biological & pharmaceutical bulletin.

Evaluation of Using Dogs to Predict Fraction of Oral Dose Absorbed in Humans for Poorly Water-Soluble Drugs.

S. Yamashita, K. Sugano, J. Katagi, 2018, Journal of pharmaceutical sciences.

In vitro-in vivo correlation of the effect of supersaturation on the intestinal absorption of BCS Class 2 drugs.

Marina Yamamoto, Y. Masaoka, M. Kataoka, 2014, Molecular pharmaceutics.

Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity.

S. Yamashita, N. Oku, M. Kakemi, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Impact of Luminal Fluid Volume on the Drug Absorption After Oral Administration: Analysis Based on In Vivo Drug Concentration-Time Profile in the Gastrointestinal Tract.

M. Kataoka, S. Yamashita, S. Sakuma, 2015, Journal of pharmaceutical sciences.

Kinetic Analysis of the Drug Permeation Process Across the Intestinal Epithelium

S. Yamashita, T. Nadai, T. Sakane, 1994, Pharmaceutical Research.

Specificity of lectin-immobilized fluorescent nanospheres for colorectal tumors in a mouse model which better resembles the clinical disease.

J. Gore, R. Hoffman, Y. Masaoka, 2015, Contrast media & molecular imaging.

Advantage of the Dissolution/Permeation System for Estimating Oral Absorption of Drug Candidates in the Drug Discovery Stage.

M. Kataoka, S. Yamashita, Y. Miyaji, 2016, Molecular pharmaceutics.

Transnasal delivery of methotrexate to brain tumors in rats: a new strategy for brain tumor chemotherapy.

S. Yamashita, H. Katsumi, A. Yamamoto, 2010, Molecular pharmaceutics.

DMD051680 1514..1521

S. Yamashita, Yoshiki Matsuda, Y. Konno, 2013 .

Preparation of fenofibrate solid dispersion using electrospray deposition and improvement in oral absorption by instantaneous post-heating of the formulation.

K. Kawakami, Shaoling Zhang, Marina Yamamoto, 2013, International journal of pharmaceutics.

Effects of Ingested Water Volume on Oral Absorption of Fenofibrate, a BCS Class II Drug, from Micronized and Amorphous Solid Dispersion Formulations in Rats.

M. Kataoka, S. Yamashita, T. Takagi, 2022, Biological & pharmaceutical bulletin.

An enteric polymer mitigates the effects of gastric pH on oral absorption of poorly soluble weak acid drugs from supersaturable formulations: A case study with dantrolene.

M. Kataoka, S. Yamashita, Keiko Minami, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Investigations of influx and accumulation processes of beta-lactam antibiotics and their role in the transmural transfer across rat jejunum.

S. Yamashita, T. Nadai, H. Sezaki, 1986, Journal of pharmacobio-dynamics.

IVIVR in oral absorption for fenofibrate immediate release tablets using dissolution and dissolution permeation methods.

P. Holm, M. Kataoka, S. Yamashita, 2010, Die Pharmazie.

Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations.

M. Kataoka, S. Yamashita, H. Harashima, 2021, Molecular pharmaceutics.

PET Imaging of the Gastrointestinal Absorption of Orally Administered Drugs in Conscious and Anesthetized Rats

Yasuyoshi Watanabe, M. Kataoka, S. Yamashita, 2011, The Journal of Nuclear Medicine.

Impact of dietary intake of medium-chain triacylglycerides on the intestinal absorption of poorly permeable compounds.

M. Kataoka, S. Yamashita, Keiko Minami, 2019, Molecular pharmaceutics.

Detection of early colorectal cancer imaged with peanut agglutinin-immobilized fluorescent nanospheres having surface poly(N-vinylacetamide) chains.

Li Tang, R. Hoffman, Y. Masaoka, 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Essence of affinity and specificity of peanut agglutinin-immobilized fluorescent nanospheres with surface poly(N-vinylacetamide) chains for colorectal cancer.

John C Gore, Makoto Kataoka, Hiroyuki Tachikawa, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Quantitative analysis of the effect of supersaturation on in vivo drug absorption.

R. Saito, S. Yamashita, M. Machida, 2010, Molecular pharmaceutics.

Usefulness of minipigs for predicting human pharmacokinetics: Prediction of distribution volume and plasma clearance.

S. Yamashita, Hiromichi Yoshimatsu, Y. Konno, 2016, Drug metabolism and pharmacokinetics.

Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models

Kengo Watanabe, S. Yamashita, M. Yamada, 2020, Drug Metabolism and Disposition.

Prediction of human percutaneous absorption from in vitro and in vivo animal experiments.

S. Yamashita, Hiromichi Yoshimatsu, Y. Konno, 2017, International journal of pharmaceutics.

Oligoarginine-linked polymers as a new class of penetration enhancers.

Y. Masaoka, M. Kataoka, S. Yamashita, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Effects of sodium or glucose exclusion from the incubation medium on drug transfer across rat jejunal membrane in vitro: an electrophysiological study.

S. Yamashita, T. Nadai, T. Kimura, 1987, Chemical and pharmaceutical bulletin.

Oral delivery of insulin by using surface coating liposomes improvement of stability of insulin in GI tract

S. Yamashita, M. Nango, N. Oku, 1997 .

Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin.

S. Yamashita, N. Oku, Y. Namba, 1999, Journal of pharmaceutical sciences.

New strategy for drug development with exploratory IND studies: scientific basis and future directions.

Y. Sugiyama, S. Yamashita, 2011, Advanced drug delivery reviews.

Analysis of Drug Permeation Across Caco-2 Monolayer: Implication for Predicting In Vivo Drug Absorption

Hitoshi Sezaki, S. Yamashita, T. Nadai, 1997, Pharmaceutical Research.

Development of in vitro M-cell model for macromolecule transport

P. Artursson, Y. Masaoka, M. Kataoka, 2004 .

New and better protocols for a short-term Caco-2 cell culture system.

Keisuke Konishi, Hitoshi Sezaki, S. Yamashita, 2002, Journal of pharmaceutical sciences.

Dodecylmaltoside Modulates Bicellular Tight Junction Contacts To Promote Enhanced Permeability.

M. Kataoka, S. Yamashita, K. Gradauer, 2017, Molecular pharmaceutics.

Evaluation of dose-dependent oral absorption of a newly developed drug candidate: In vitro-in vivo correlation

M. Kataoka, S. Yamashita, S. Sakuma, 2016 .

Effect of Excipients on the Particle Size of Precipitated Pioglitazone in the Gastrointestinal Tract: Impact on Bioequivalence

M. Kataoka, S. Yamashita, Masahisa Sugihara, 2014, The AAPS Journal.

Mechanisms of membrane transport of poorly soluble drugs: role of micelles in oral absorption processes.

Y. Masaoka, M. Kataoka, S. Yamashita, 2010, Journal of pharmaceutical sciences.

Analysis of Intra- and Intersubject Variability in Oral Drug Absorption in Human Bioequivalence Studies of 113 Generic Products.

M. Kataoka, S. Yamashita, K. Higaki, 2015, Molecular pharmaceutics.

In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context.

H Lennernäs, A Lindahl, A Van Peer, 2017, Molecular pharmaceutics.

A perspective for biowaivers of human bioequivalence studies on the basis of the combination of the ratio of AUC to the dose and the biopharmaceutics classification system.

S. Yamashita, S. Sakuma, Yoshinobu Yamamoto, 2011, Molecular pharmaceutics.

Analysis of risk factors in human bioequivalence study that incur bioinequivalence of oral drug products.

S. Yamashita, H. Tachiki, 2009, Molecular pharmaceutics.

Lowly-buffered biorelevant dissolution testing is not necessarily biopredictive of human bioequivalence study outcome: Relationship between dissolution and pharmacokinetics.

S. Yamashita, K. Matsui, S. Yokota, 2022, International journal of pharmaceutics.

Application of Dissolution/Permeation System for Evaluation of Formulation Effect on Oral Absorption of Poorly Water-Soluble Drugs in Drug Development

Y. Masaoka, M. Kataoka, S. Yamashita, 2012, Pharmaceutical Research.

Oral Drug Absorption

S. Yamashita, 2006 .

IVIVR in oral absorption for fenofibrate immediate release tablets using dissolution and dissolution permeation methods.

P. Holm, M. Kataoka, S. Yamashita, 2010, Pharmazie.

5-Fluorouracil derivatives with serum protein binding potencies.

S. Yamashita, Y. Suda, T. Nadai, 1989, Chemical and pharmaceutical bulletin.

The species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans.

S. Yamashita, N. Suzuki, Shinji Yamashita, 2009, Journal of pharmaceutical sciences.

Transnasal delivery of anticancer drugs to the brain tumor : A new strategy for brain tumor chemotherapy

S. Shibata, S. Yamashita, T. Sakane, 1999 .

Induction of human P-glycoprotein in Caco-2 cells: development of a highly sensitive assay system for P-glycoprotein-mediated drug transport.

S. Yamashita, T. Sakaeda, K. Okumura, 2006, Drug metabolism and pharmacokinetics.

Dynamic Analysis of GI Absorption and Hepatic Distribution Processes of Telmisartan in Rats Using Positron Emission Tomography

Yasuyoshi Watanabe, Y. Sugiyama, Y. Masaoka, 2012, Pharmaceutical Research.

Scale-up of in vitro permeation assay data to human intestinal permeability using pore theory.

Y. Masaoka, M. Kataoka, S. Yamashita, 2011, International journal of pharmaceutics.

Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective.

R. Hoffman, S. Yamashita, S. Sakuma, 2011, Current drug discovery technologies.

Increase in the systemic exposure of primary metabolites of Midazolam in rat arising from CYP inhibition or hepatic dysfunction.

M. Kataoka, S. Yamashita, Y. Shitara, 2017, Drug metabolism and pharmacokinetics.

Kinetic model to predict the absorption of nasally applied drugs from in vitro transcellular permeability of drugs.

Y. Masaoka, M. Kataoka, S. Yamashita, 2007, Biological & pharmaceutical bulletin.

Quantitative Assessment of Intestinal First-pass Metabolism of Oral Drugs Using Portal-vein Cannulated Rats

S. Yamashita, Yoshiki Matsuda, Y. Konno, 2015, Pharmaceutical Research.

Performance of cell-penetrating peptide-linked polymers physically mixed with poorly membrane-permeable molecules on cell membranes.

S. Maeda, Y. Masaoka, M. Kataoka, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Investigation of the intestinal permeability and first-pass metabolism of drugs in cynomolgus monkeys using single-pass intestinal perfusion.

S. Yamashita, N. Suzuki, Masayuki Takahashi, 2010, Biological & pharmaceutical bulletin.

A theoretical-empirical analysis on the initial dissolution rate of drugs from polydispersed particles.

S. Yamashita, Koji Shiraki, Noriyuki Takata, 2009, Biological & pharmaceutical bulletin.

In vitro -in vivo correlation in the effect of cyclodextrin on oral absorption of poorly soluble drugs.

M. Kataoka, S. Yamashita, T. Takagi, 2021, International journal of pharmaceutics.

Assessment of absorption potential of poorly water-soluble drugs by using the dissolution/permeation system.

Y. Masaoka, M. Kataoka, S. Yamashita, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Assessment of Drug Disposition in the Perfused Rat Brain by Statistical Moment Analysis

Mitsuru Hashida, Akira Yamamoto, Hitoshi Sezaki, 1991, Pharmaceutical Research.

Establishment of MDCKII cell monolayer with metabolic activity by CYP3A4 transduced with recombinant adenovirus.

Y. Masaoka, M. Kataoka, S. Yamashita, 2013, Drug metabolism and pharmacokinetics.

First‐pass Metabolism of Peptide Drugs in Rat Perfused Liver

G. Amidon, S. Yamashita, P. Langguth, 1998, The Journal of pharmacy and pharmacology.

IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution/permeation system.

M. Kataoka, S. Yamashita, P. Langguth, 2009, Journal of pharmaceutical sciences.

Further improvement of orally disintegrating tablets using micronized ethylcellulose.

S. Yamashita, K. Okimoto, T. Ōsawa, 2012, International journal of pharmaceutics.

Application of Dissolution/Permeation System for Evaluation of Formulation Effect on Oral Absorption of Poorly Water-Soluble Drugs in Drug Development

Y. Masaoka, M. Kataoka, S. Yamashita, 2011, Pharmaceutical Research.

New biphasic system in side-by-side chambers for testing drug dissolution and permeation in vitro (BiDP system)

M. Kataoka, S. Yamashita, T. Takagi, 2021 .

Interaction with Mixed Micelles in the Intestine Attenuates the Permeation Enhancing Potential of Alkyl-Maltosides.

B. Pedersen, M. Kataoka, S. Yamashita, 2015, Molecular pharmaceutics.

A new in vitro system for evaluation of passive intestinal drug absorption: establishment of a double artificial membrane permeation assay.

Y. Masaoka, M. Kataoka, S. Yamashita, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Control of Dissolution and Supersaturation/Precipitation of Poorly Water-Soluble Drugs from Cocrystals Based on Solubility Products: A Case Study with a Ketoconazole Cocrystal.

M. Kataoka, S. Yamashita, T. Takagi, 2023, Molecular pharmaceutics.

Effect of experimental acute renal failure on barriers to permeation of a polar drug in rat jejunum: an electrophysiological analysis.

S. Yamashita, T. Nadai, T. Kimura, 1988, Chemical & pharmaceutical bulletin.

Expression levels of human P-glycoprotein in in vitro cell lines: correlation between mRNA and protein levels for P-glycoprotein expressed in cells.

S. Yamashita, T. Sakaeda, Y. Shirasaka, 2009, Biopharmaceutics & drug disposition.

Modified Polyanionic Polymers. I: Grafting of Hydrophobic Group onto Poly(maleic acid-alt-3,4- dihydroxyphenylprop-1-ene) to Improve the Affinity for Cell Membranes

S. Yamashita, N. Oku, Y. Suda, 1992 .