K. Fukase

M. Matsushita, Ken Watanabe, K. Kabayama, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Detection of UDP-D-Xylose:α-D-Xyloside α→3Xylosyltransferase Activity in Human Hepatoma Cell Line HepG2

K. Fukase, S. Kusumoto, S. Natsuka, 1996 .

Lymphoid Tissue–Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells

H. Kiyono, K. Fukase, T. Nagatake, 2020, Frontiers in Microbiology.

Chemical Synthesis of a Complex-Type N-Glycan Containing a Core Fucose.

Katsunori Tanaka, Y. Manabe, K. Fukase, 2016, The Journal of organic chemistry.

Efficient Synthesis of Antigenic Trisaccharides ContainingN-Acetylglucosamine: Protection of NHAc as NAc2

Y. Manabe, K. Fukase, Masato Tsutsui, 2020 .

The Core Fucose on an IgG Antibody is an Endogenous Ligand of Dectin‐1

Katsunori Tanaka, Y. Yamaguchi, S. Hanashima, 2019, Angewandte Chemie.

Convergent Synthesis of a Bisecting N-Acetylglucosamine (GlcNAc)-Containing N-Glycan.

Katsunori Tanaka, Y. Manabe, K. Fukase, 2018, Chemistry, an Asian journal.

Efficient Glycosylation Using In(OTf)3 as a Lewis Acid: Activation of N-Phenyltrifluoroacetimidate or Thioglycosides with Halogenated Reagents or PhIO

Y. Manabe, Tsung-Che Chang, K. Fukase, 2014 .

Practical and Efficient Method for α-Sialylation with an Azide Sialyl Donor Using a Microreactor

Katsunori Tanaka, Y. Manabe, K. Fukase, 2014 .

Highly Efficient α‐Sialylation by Virtue of Fixed Dipole Effects of N‐Phthalyl Group: Application to Continuous Flow Synthesis of α(2‐3)‐and α(2‐6)‐Neu5Ac‐Gal Motifs by Microreactor

Katsunori Tanaka, K. Fukase, Shin-ichi Tanaka, 2007 .

Development of α‐Gal–Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies

S. Hung, M. Tanemura, Y. Manabe, 2019, Angewandte Chemie.

Development of α-Gal-Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies.

S. Hung, M. Tanemura, Y. Manabe, 2019, Angewandte Chemie.

Probe design and synthesis of Galbeta(1-->3)[NeuAcalpha(2-->6)]GlcNAcbeta(1-->2)Man motif of N-glycan.

Katsunori Tanaka, K. Fukase, K. Ikenaka, 2010, Bioorganic & medicinal chemistry.

Bio-imaging and cancer targeting with glycoproteins and N-glycans.

Katsunori Tanaka, K. Fukase, 2012, Current opinion in chemical biology.

Nod1 Ligands Induce Site-Specific Vascular Inflammation

T. Hara, K. Sueishi, K. Kusuhara, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity

Kenichi Sato, Toshiyuki Shimizu, A. Cattaneo, 2020, The EMBO journal.

Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses.

K. Fukase, N. Inohara, A. R. Pradipta, 2016, Organic & biomolecular chemistry.

Homeostatic and pathogenic roles of the GM3 ganglioside

K. Fukase, J. Inokuchi, K. Inamori, 2021, The FEBS journal.

Pulmonary Inflammation in Mice and Dampen Lipopolysaccharide-Induced Lipopolysaccharide Binding on Cell Surface TLR4 Domain and MD-2 Inhibit Recombinant Soluble Forms of Extracellular

K. Fukase, H. Sano, Takeyuki Shimizu, 2006 .

Recombinant Soluble Forms of Extracellular TLR4 Domain and MD-2 Inhibit Lipopolysaccharide Binding on Cell Surface and Dampen Lipopolysaccharide-Induced Pulmonary Inflammation in Mice1

K. Fukase, H. Sano, Takeyuki Shimizu, 2006, The Journal of Immunology.

Acceleration of Cu(I)-Mediated Huisgen 1,3-Dipolar Cycloaddition by Histidine Derivatives : Library Synthesis of "Self-Activating" Click Peptides

Katsunori Tanaka, K. Fukase, Sanae Shirotsuki, 2007 .

Efficient synthesis of 2,6,9-triazabicyclo[3.3.1]nonanes through amine-mediated formal [4+4] reaction of unsaturated imines

Katsunori Tanaka, Y. Kitagawa, K. Fukase, 2012 .

Novel oxidatively removable protecting groups and linkers for solid-phase synthesis of oligosaccharides

K. Fukase, S. Kusumoto, Kenji Egusa, 2005, Molecular Diversity.

Target-selective fluorescent "switch-on" protein labeling by 6π-azaelectrocyclization.

Katsunori Tanaka, K. Fukase, Masataka Kitadani, 2011, Organic & biomolecular chemistry.

Peptidoglycan microarray as a novel tool to explore protein–ligand recognition

K. Fukase, K. Nokihara, A. Hirata, 2016, Biopolymers.

Glycan Sequence‐Dependent Nod2 Activation Investigated by Using a Chemically Synthesized Bacterial Peptidoglycan Fragment Library

K. Fukase, N. Inohara, M. Hasegawa, 2013, Chembiochem : a European journal of chemical biology.

Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation.

K. Fukase, N. Inohara, A. R. Pradipta, 2012, Natural product reports.

Cytotoxic Activity of Ursolic Acid Derivatives Obtained by Isolation and Oxidative Derivatization

Katsunori Tanaka, K. Fukase, K. Mazumder, 2013, Molecules.

Whole-body imaging of tumor cells by azaelectrocyclization: visualization of metastasis dependence on glycan structure.

Katsunori Tanaka, K. Fukase, E. Miyoshi, 2013, Bioorganic & medicinal chemistry.

A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cells.

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2014, Organic & biomolecular chemistry.

Differential Modulation of Nods Signaling Pathways by Fatty Acids in Human Colonic Epithelial HCT116 Cells*

K. Fukase, N. Inohara, Ling Zhao, 2007, Journal of Biological Chemistry.

Functional fluorescence labeling of carbohydrates and its use for preparation of neoglycoconjugates

M. Kurosawa, K. Fukase, S. Kusumoto, 1994 .

Mannose-Binding Lectin Augments the Uptake of Lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer Cells through Increased Cell Surface Expression of Scavenger Receptor A1

T. Kodama, Hiroshi Suzuki, K. Hirata, 2006, The Journal of Immunology.

Mannose-Binding Lectin Augments the Uptake of Lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer Cells through Increased Cell Surface Expression of Scavenger Receptor A

Shimizu, T. Kodama, K. Fukase, 2006 .

Scavenger Receptor A through Increased Cell Surface Expression of by Kupffer Cells Escherichia coli and , Staphylococcus aureus Uptake of Lipid A , Mannose-Binding Lectin Augments the Kuroki

T. Kodama, Hiroshi Suzuki, K. Hirata, 2006 .

Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine

H. Kiyono, K. Fukase, T. Nagatake, 2021, Frontiers in Pharmacology.

Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A.

K. Fukase, Y. Suda, Y. Fujimoto, 2012, Carbohydrate research.

Chemical synthesis of Helicobacter pylori lipopolysaccharide partial structures and their selective proinflammatory responses.

K. Fukase, K. Miyake, H. Tsutsui, 2011, Chemistry.

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

E. Alnemri, M. Chamaillard, Grace Y Chen, 2018, Cell.

Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine.

K. Fukase, Tadao Saito, H. Aso, 2008, Molecular immunology.

Synthesis of bacterial glycoconjugates and their bio-functional studies in innate immunity

Katsunori Tanaka, K. Fukase, Y. Fujimoto, 2012 .

Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease

H. Takada, T. Hara, T. Yano, 2017, Clinical and Experimental Immunology.

Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation.

Katsunori Tanaka, M. Sodeoka, T. Hosoya, 2013, Organic & biomolecular chemistry.

Shigella protein IpaH ( 9 . 8 ) is secreted from bacteria within mammalian cells and transported to the nucleus

Hirotaka, K. Fukase, Y. Nagai, 2002 .

Evidence of Immunostimulating Lipoprotein Existing in the Natural Lipoteichoic Acid Fraction

M. Hashimoto, T. Kirikae, K. Fukase, 2007, Infection and Immunity.

Dendritic Cell Maturation Induced by Muramyl Dipeptide (MDP) Derivatives: Monoacylated MDP Confers TLR2/TLR4 Activation1

S. Akira, S. Uematsu, K. Fukase, 2005, The Journal of Immunology.

Synthesis of [211At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution

T. Watabe, E. Shimosegawa, J. Hatazawa, 2021, Scientific Reports.

Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies

K. Fukase, S. Kusumoto, T. Shiba, 2010, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Synthesis of Cyclopropane Fatty Acids by C(sp3)−C(sp3) Cross-Coupling Reaction and Formal Synthesis of α-Mycolic Acid

K. Fukase, N. Kambe, T. Iwasaki, 2018, Advanced Synthesis & Catalysis.

Library-directed solution- and solid-phase synthesis of 2,4-disubstituted pyridines: one-pot approach through 6pi-azaelectrocyclization.

Katsunori Tanaka, S. Katsumura, K. Fukase, 2009, Chemistry, an Asian journal.

α‐Emitting cancer therapy using 211At‐AAMT targeting LAT1

T. Watabe, J. Hatazawa, Y. Kanai, 2020, Cancer science.

Limonoids with anti-inflammatory activity: A review.

K. Kabayama, K. Fukase, U. Supratman, 2022, Phytochemistry.

Meso-diaminopimelic acid and meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD1.

L. P. Sousa, K. Fukase, S. Kusumoto, 2008, The Journal of Immunology.

Chemically Synthesized TLR4 Ligands, Their Immunological Functions, and Potential as Vaccine Adjuvant

K. Fukase, A. Shimoyama, 2020 .

Synthesis and biofunctional study of bacterial glycoconjugates

K. Fukase, A. R. Pradipta, Y. Fujimoto, 2008 .

Synthesis and bioactivity of fluorescence- and biotin-labeled lipid A analogues for investigation of recognition mechanism in innate immunity

K. Fukase, S. Kusumoto, E. Kimura, 2006 .

Cell activation by monosaccharide lipid A analogues utilizing Toll‐like receptor 4

T. Ogawa, Y. Asai, M. Hashimoto, 2003, Immunology.

Endotoxic and immunobiological activities of a chemically synthesized lipid A of Helicobacter pylori strain 206-1.

T. Ogawa, Y. Asai, K. Fukase, 2003, FEMS immunology and medical microbiology.

Synthesis of [3H]-Labeled Bioactive Lipid A Analogs and Their Use for Detection of Lipid A-Binding Proteins on Murine Macrophages.

T. Kirikae, M. Kurosawa, K. Fukase, 2001 .

Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities

K. Fukase, S. Kusumoto, Y. Suda, 1995, Infection and immunity.

Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant

K. Fukase, P. Kováč, R. Saksena, 2009, Glycoconjugate Journal.

Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity

K. Ishii, H. Kiyono, Shintaro Sato, 2018, Mucosal Immunology.

Unveiling Molecular Recognition of Sialoglycans by Human Siglec-10

P. Del Vecchio, A. Arciello, Y. Manabe, 2020, iScience.

Nod1/RICK and TLR Signaling Regulate Chemokine and Antimicrobial Innate Immune Responses in Mesothelial Cells1

G. Núñez, K. Fukase, Yun-Gi Kim, 2007, The Journal of Immunology.

Nucleotide Oligomerization Binding Domain-Like Receptor Signaling Enhances Dendritic Cell-Mediated Cross-Priming In Vivo

T. Mak, Taku Sato, A. Suzuki, 2009, The Journal of Immunology.

VivoDendritic Cell-Mediated Cross-Priming In Domain-Like Receptor Signaling Enhances Nucleotide-Binding Oligomerization

K. Fukase, H. Tada, T. Ohteki, 2009 .

Immune Responses in Mesothelial Cells Chemokine and Antimicrobial Innate Nod 1 / RICK and TLR Signaling Regulate

G. Núñez, K. Fukase, Yun-Gi Kim, 2007 .

Meso-Diaminopimelic Acid and Meso-Lanthionine, Amino Acids Specific to Bacterial Peptidoglycans, Activate Human Epithelial Cells through NOD11

K. Fukase, S. Kusumoto, A. Uehara, 2006, The Journal of Immunology.

Upregulation of PGRPs by chemically synthesized pathogen-associated molecular patterns via Toll-like receptors, NOD1 and NOD2 in oral epithelial cells

K. Fukase, K. Shibata, S. Kusumoto, 2005 .

One-Pot Evolution of Ageladine A through a Bio-Inspired Cascade towards Selective Modulators of Neuronal Differentiation.

Katsunori Tanaka, K. Fukase, Kazuki Tsubokura, 2016, Chemistry.

Rationale for Translational Research on Targeted Alpha Therapy in Japan —Renaissance of Radiopharmaceuticals Utilizing Astatine-211 and Actinium-225—

Y. Yonekura, T. Watabe, M. Tatsumi, 2020, RADIOISOTOPES.

ReviewRecent Advances in the Chemical Biology of N-GlycansAsuka Shirakawa 1

Y. Manabe, K. Fukase, Asuka Shirakawa, 2021 .

Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids.

K. Fukase, S. Inuki, Y. Fujimoto, 2017, The Journal of organic chemistry.

Lipopolysaccharide-binding protein-mediated interaction of lipid A from different origin with phospholipid membranes

M. Koch, K. Fukase, S. Kusumoto, 2000 .

A biophysical approach towards an understanding of endotoxin-induced signal transduction

K. Fukase, E. Rietschel, S. Kusumoto, 1999 .

Chemoenzymatic synthesis of Gal(β1-3)Gal(β1-4)Xyl(β)-l-Ser and Gal(β1-3)Gal(β1-4)Xyl(β)-MU by the use of β-d-galactosidase

K. Fukase, S. Kusumoto, Y. Suda, 1996 .

Synthesis of new serine-linked oligosaccharides in blood-clotting factors VII and IX and protein Z. The syntheses of O-α-D-Xylopyranosyl-(1→3)-D-glucopyranose, O-α-D-Xylopyranosyl-(1→3)-O-α-D-xylopyranosyl-(1→3)-D-glucopyranose, and their conjugates with serine

K. Fukase, S. Kusumoto, T. Ikenaka, 1992 .

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.

Toshiyuki Shimizu, K. Fukase, K. Miyake, 2014, International immunology.

Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity.

K. Fukase, S. Kusumoto, I. Fraser, 2005, Blood.

Noninvasive imaging of dendrimer-type N-glycan clusters: in vivo dynamics dependence on oligosaccharide structure.

Yasuyoshi Watanabe, Katsunori Tanaka, J. Paulson, 2010, Angewandte Chemie.

ChemInform Abstract: Synthetic Study of Peptidoglycan Partial Structures. Synthesis of Tetrasaccharide and Octasaccharide Fragments.

K. Fukase, S. Kusumoto, S. Inamura, 2001 .

Synthesis of Rubrivivax gelatinosus Lipid A and Analogues for Investigation of the Structural Basis for Immunostimulating and Inhibitory Activities

K. Fukase, S. Kusumoto, Y. Suda, 2008 .

Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity.

K. Fukase, S. Kusumoto, K. Brandenburg, 2000, European journal of biochemistry.

Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex

M. Bernardini, M. Fresno, K. Fukase, 2018, Frontiers in Immunology.

Differential Activation of Human TLR4 by Escherichia coli and Shigella flexneri 2a Lipopolysaccharide: Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on Signaling1

A. Awomoyi, K. Fukase, S. Vogel, 2008, The Journal of Immunology.

Cell surface biotinylation by azaelectrocyclization: easy-handling and versatile approach for living cell labeling.

Katsunori Tanaka, K. Fukase, Takeshi Fujiwara, 2012, Bioorganic & medicinal chemistry.

Electrocyclization‐Based Labeling Allows Efficient In Vivo Imaging of Cellular Trafficking

H. Onoe, Yasuyoshi Watanabe, Katsunori Tanaka, 2010, ChemMedChem.

Conjugation Strategies for Development of Bioactive Middle Molecules

Y. Manabe, K. Kabayama, K. Fukase, 2021, Middle Molecular Strategy.

Oligosaccharide Synthesis on Solid, Soluble Polymer, and Tag Supports

Katsunori Tanaka, K. Fukase, 2011 .

Polymer-Supported and Tag-Assisted Methods in Oligosaccharide Synthesis

Katsunori Tanaka, K. Fukase, 2008 .

A Combined 6π-Azaelectrocyclization/Staudinger Approach to Protein and Cell Engineering: Noninvasive Tumor Targeting by N-Glycan-Engineered Lymphocytes

H. Onoe, Yasuyoshi Watanabe, Katsunori Tanaka, 2010 .

Targeted α-therapy using astatine (211At)-labeled PSMA1, 5, and 6: a preclinical evaluation as a novel compound

T. Watabe, F. Giesel, N. Tomiyama, 2022, European Journal of Nuclear Medicine and Molecular Imaging.

New synthesis and conformational analysis of lipid A: biological activity and supramolecular assembly

K. Fukase, S. Kusumoto, Y. Suda, 1999 .

A non-carboxylating pentose bisphosphate pathway in halophilic archaea

H. Atomi, Y. Manabe, K. Fukase, 2022, Communications Biology.

Ursolic acid derivatives from Bangladeshi medicinal plant, Saurauja roxburghii: Isolation and cytotoxic activity against A431 and C6 glioma cell lines

Yasuyoshi Watanabe, Katsunori Tanaka, S. Nozaki, 2011 .

Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity

S. Gronow, M. Koch, K. Fukase, 2005, The FEBS journal.

IEIIS Meeting minireview: Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism

K. Fukase, S. Kusumoto, Zenyu Shiokawa, 2007, Journal of endotoxin research.

Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection

K. Fukase, Shinji Tanaka, E. Tannich, 2017, Scientific Reports.

Enzymatic Synthesis of 4-Methylumbelliferyl Glycosides of Trisaccharide and Core Tetrasaccharide, Gal(β1-3)Gal(β1-4)Xyl and GlcA(β1-3)Gal(β1-3)Gal(β1-4)Xyl, Corresponding to the Linkage Region of Proteoglycans.

K. Fukase, S. Kusumoto, Y. Suda, 1998 .

Branched Sialylated N-glycans Are Accumulated in Brain Synaptosomes and Interact with Siglec-H.

Katsunori Tanaka, H. Kiyama, Y. Fukata, 2018, Cell structure and function.

Synthesis of cyclotetrapeptide analogues of c-PLAI and evaluation of their antimicrobial properties

K. Fukase, U. Supratman, Nurlelasari, 2021, Royal Society Open Science.

New efficient route for solid-phase synthesis of benzimidazole derivatives.

K. Fukase, S. Kusumoto, H. Akamatsu, 2002, Journal of combinatorial chemistry.

Iodosobenzene-triflic anhydride as an efficient promoter for glycosidation reaction using thioglycosides as donors

K. Fukase, S. Kusumoto, A. Hasuoka, 1992 .

A stereoselective glycosidation using thioglycosides, activation by combination of N-bromosuccinimide and strong acid salts

K. Fukase, S. Kusumoto, A. Hasuoka, 1995 .

Nitropyridyl glycosides: new glycosyl donors for enzymatic transglycosylation

K. Fukase, S. Kusumoto, C. Inaba, 1999 .

K. Fukase, S. Kusumoto, Y. Suda, 1997 .

Acid-mediated reactions under microfluidic conditions: A new strategy for practical synthesis of biofunctional natural products

Katsunori Tanaka, K. Fukase, 2009, Beilstein journal of organic chemistry.

Reactivity switching on solid support: solid-phase synthesis of tertiary amines by reduction of tertiary amides with LiAlH4

K. Fukase, S. Kusumoto, H. Akamatsu, 2002 .

Effects of dehydroalanine on peptide conformations

Murray Goodman, Koichi Fukase, K. Fukase, 1992 .

Synthetic study on peptide antibiotic nisin. IV, Synthesis of ring D-E

K. Fukase, A. Sano, T. Shiba, 1990 .

Widely Applicable Deprotection Method of 2,2,2-Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride

K. Fukase, Y. Fujimoto, Katsumasa Fujiki, 2010 .

Synthetic route for 14C-labeling of a bioactive lipid a analogue

M. Kurosawa, K. Fukase, E. Rietschel, 1995 .

Synthetic Study on Lipoteichoic Acid of Gram Positive Bacteria. I. Synthesis of Proposed Fundamental Structure of Streptococcus pyogenes Lipoteichoic Acid

K. Fukase, S. Kusumoto, Takahiro Matsumoto, 1992 .

Lithium Tetra(pentafluorophenyl)borate

Katsunori Tanaka, K. Fukase, 2007, Encyclopedia of Reagents for Organic Synthesis.

Flow Dehydration and Hydrogenation of Allylic Alcohols: Application to the Waste-Free Synthesis of Pristane

T. Fukuyama, I. Ryu, Y. Manabe, 2017 .

Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl Grignard reagents: a practical and versatile method for preparing fatty acids.

K. Fukase, N. Kambe, J. Terao, 2013, Chemistry.

Discovery and application of 6π-azaelectrocyclization to natural product synthesis and synthetic biology

Katsunori Tanaka, S. Katsumura, K. Fukase, 2012, Science China Chemistry.

Chemical synthesis of cyclodextrins by using intramolecular glycosylation.

Masahiro Wakao, K. Fukase, S. Kusumoto, 2002, The Journal of organic chemistry.

Revisiting the bromination of C-H bonds with molecular bromine by using a photo-microflow system.

T. Fukuyama, I. Ryu, H. Matsubara, 2014, Chemistry.

First Total Synthesis of the Re-Type Lipopolysaccharide.

K. Fukase, S. Kusumoto, Y. Suda, 2001, Angewandte Chemie.

Chemical Approach to a Whole Body Imaging of Sialo-N-Linked Glycans.

Katsunori Tanaka, K. Fukase, 2015, Topics in current chemistry.

New strategy in synthetic biology: from enzyme inhibition and natural products synthesis to PET imaging by 6pi-azaelectrocyclization.

Katsunori Tanaka, S. Katsumura, K. Fukase, 2010, Chemical record.

Regioselective Reductive Opening of 4,6-O-Benzylidene Acetals of Glucose or Glucosamine Derivatives by BH3⋅Me2NH - BF3⋅OEt2

K. Fukase, S. Kusumoto, M. Oikawa, 1996 .

Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex

T. Hirokawa, Toshiyuki Shimizu, K. Takatsu, 2017, The Journal of Biological Chemistry.

A Reduction-Based Sensor for Acrolein Conjugates with the Inexpensive Nitrobenzene as an Alternative to Monoclonal Antibody

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2016, Scientific Reports.

Facile Preparation of 1,5-Diazacyclooctanes from Unsaturated Imines: Effects of the Hydroxyl Groups on [4+4] Dimerization

Katsunori Tanaka, Y. Kitagawa, Y. Manabe, 2014 .

Synthetic study on peptide antibiotic nisin. V : Total synthesis of nisin

H. Fujita, K. Fukase, A. Sano, 1992 .

SYNTHESES OF FOUR STEREOISOMERS OF β-METHYLLANTHIONINE

K. Fukase, T. Shiba, Y. Oda, 1985 .

An Improved Synthesis of threo-3-Methyl-D-cysteine

K. Fukase, T. Shiba, T. Wakamiya, 1983 .

Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functions.

K. Fukase, N. Inohara, M. Hasegawa, 2008, Chemistry.

A Review of Cytotoxic Plants of the Indian Subcontinent and a Broad-Spectrum Analysis of Their Bioactive Compounds

K. Fukase, B. Biswas, K. Mazumder, 2020, Molecules.

Synthesis of endotoxic principle of bacterial lipopolysaccharide and its recognition by the innate immune systems of hosts.

K. Fukase, S. Kusumoto, 2006, Chemical record.

Synthesis of Helicobacter pylori lipid A and its analogue using p-(trifluoromethyl)benzyl protecting group

T. Ogawa, K. Fukase, S. Kusumoto, 2000 .

Bio-inspired Domino Reduction of Nitroarenes by Acrolein–Amine Conjugates in One-pot Operation

Katsunori Tanaka, K. Fukase, Masayuki Takamatsu, 2017 .

p-Nitrophenyl group for anomeric protection of oligosaccharides, selective oxidative cleavage via p-acetamidophenyl glycosides

K. Fukase, S. Kusumoto, Yoshihiko Nakai, 1996 .

A Novel Method for Stereoselective Glycosidation with Thioglycosides: Promotion by Hypervalent Iodine Reagents Prepared from PhIO and Various Acids?

K. Fukase, S. Kusumoto, A. Hasuoka, 1996 .

Practical Synthesis of a Manβ(1-4)GlcNTroc Fragment via Microfluidic β-Mannosylation

Katsunori Tanaka, K. Fukase, Yasutaka Mori, 2009 .

Chlorotrimethylsilane as a Mild and Effective Source of Acid Catalyst in Reductive Benzylation

Minoru Izumi, K. Fukase, 2005 .

Employing BINOL-Phosphoroselenoyl Chloride for Selective Inositol Phosphorylation and Synthesis of Glycosyl Inositol Phospholipid from Entamoeba histolytica.

K. Fukase, T. Murai, H. Lotter, 2017, Chemistry.

Regioselective phosphorylation of myo-inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol.

K. Fukase, N. Kambe, T. Iwasaki, 2016, Organic & biomolecular chemistry.

3-Nitro-2-pyridyl glycoside as donor for chemical glycosylation and its application to chemoenzymatic synthesis of oligosaccharide

K. Fukase, S. Kusumoto, T. Yasukochi, 1999 .

Product Selectivity of Esterification of L-Aspartic Acid and L-Glutamic Acid Using Chlorotrimethylsilane

Minoru Izumi, K. Fukase, H. Kiyota, 2017, Natural product communications.

Solid-phase Synthesis of Bacterial Cell Wall Peptidoglycan Fragments

K. Fukase, Y. Fujimoto, Yuichiro Kadonaga, 2014 .

Widely Applicable Deprotection Method of 2,2,2‐Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride.

K. Fukase, Y. Fujimoto, Katsumasa Fujiki, 2011 .

Synthetic Study of Peptidoglycan Partial Structures. Synthesis of Tetrasaccharide and Octasaccharide Fragments.

K. Fukase, S. Kusumoto, S. Inamura, 2010 .

New deprotection method of the 2,2,2-trichloroethoxycarbonyl (Troc) group with (Bu3Sn)2

K. Fukase, Hiroomi Tokimoto, 2005 .

Efficient Synthesis of the Disialylated Tetrasaccharide Motif in N-Glycans through an Amide-Protection Strategy.

Katsunori Tanaka, Y. Manabe, K. Fukase, 2016, Chemistry, an Asian journal.

Synthesis of Lipopolysaccharide, Peptidoglycan, and Lipoteichoic Acid Fragments

K. Fukase, S. Kusumoto, Y. Fujimoto, 2007 .

Synthetic Study of Lipoteichoic Acid of Gram Positive Bacteria. II. Synthesis of the Proposed Fundamental Structure of Enterococcus hirae Lipoteichoic Acid

K. Fukase, S. Kusumoto, S. Kotani, 1994 .

4-Pivaloylaminobenzyl ether, a new temporary protection for hydroxyl functions

K. Fukase, S. Kusumoto, T. Yoshimura, 1991 .

Application of 4-azidobenzyl group to protection of hydroxyl functions

K. Fukase, S. Kusumoto, M. Hashida, 1991 .

4-Nitrobenzyl Group for Protection of Hydroxyl Functions.

K. Fukase, S. Kusumoto, Hideo Tanaka, 1990 .

Synthetic Study on Lipoteichoic Acid of Gram Positive Bacteria. Part 1. Synthesis of the Proposed Fundamental Structure of Streptococcus pyogenes Lipoteichoic Acid

K. Fukase, S. Kusumoto, Takuya Matsumoto, 1993 .

Synthesis of 13C-Labeled Biosynthetic Precursor of Lipid A and Its Analogue with Shorter Acyl Chains

K. Fukase, S. Kusumoto, M. Oikawa, 1999 .

Chemical synthesis of cyclodextrins by using intramolecular glycosylation.

Masahiro Wakao, K. Fukase, S. Kusumoto, 2002, The Journal of organic chemistry.

Syntheses of N-aryl-protected glucosamines and their stereoselectivity in chemical glycosylations

K. Fukase, Toshihiro Yamamoto, Yuji Otsuka, 2017 .

Total Syntheses of C60- and C100-Dolichols.

H. Atomi, Y. Manabe, K. Fukase, 2020, The Journal of organic chemistry.

A conformationally fixed analog of the peptide mimic Grb2-SH2 domain: synthesis and evaluation against the A431 cancer cell.

H. Onoe, Yasuyoshi Watanabe, Katsunori Tanaka, 2013, Molecular bioSystems.

Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu).

Koichi Fukase, Yukari Fujimoto, M. Hashimoto, 2013, Journal of bioscience and bioengineering.

Auxiliary-directed oxidation of ursolic acid by ‘Ru’-porphyrins: chemical modulation of cytotoxicity against tumor cell lines

Yasuyoshi Watanabe, Katsunori Tanaka, S. Nozaki, 2012 .

Development of a simple assay system for protein-stabilizing efficiency based on hemoglobin protection against denaturation and measurement of the cooperative effect of mixing protein stabilizers

Y. Manabe, K. Fukase, Naoya Minamoto, 2016, Bioscience, biotechnology, and biochemistry.

Kinetically Controlled Fischer Glycosidation under Flow Conditions: A New Method for Preparing Furanosides

T. Fukuyama, I. Ryu, Y. Manabe, 2019, Synlett.

Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells

M. Koch, K. Fukase, U. Zähringer, 2010, Innate immunity.

Synthesis of lipid A monosaccharide analogues containing acidic amino acid: exploring the structural basis for the endotoxic and antagonistic activities.

K. Fukase, S. Kusumoto, Y. Suda, 2006, Bioorganic & medicinal chemistry.

A Synthetic Peptidoglycan Fragment as a Competitive Inhibitor of the Melanization Cascade*

K. Fukase, S. Kusumoto, K. Söderhäll, 2006, Journal of Biological Chemistry.

A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation

P. Lucas, H. Nakano, G. Núñez, 2008 .

Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

S. Foster, M. Hashimoto, Y. Ogura, 2003, The Journal of Biological Chemistry.

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

S. Foster, T. Mak, M. Hashimoto, 2003, Nature Immunology.

Porous nanosheet wrapping for live imaging of suspension cells.

K. Kabayama, K. Fukase, Hong Zhang, 2018, Journal of materials chemistry. B.

NMR conformational analysis of biosynthetic precursor-type lipid A: monomolecular state and supramolecular assembly.

K. Fukase, S. Kusumoto, M. Oikawa, 2004, Organic & biomolecular chemistry.

The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cells

M. Hashimoto, K. Fukase, T. Seya, 2018, Innate immunity.

The Peptide Sequence of Diacyl Lipopeptides Determines Dendritic Cell TLR2-Mediated NK Activation

Sayuri Yamazaki, Koichi Fukase, Tsukasa Seya, 2010, PloS one.

Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities

M. Hashimoto, K. Fukase, Y. Suda, 2009, Chembiochem : a European journal of chemical biology.

Characterization of N-terminal Structure of TLR2-activating Lipoprotein in Staphylococcus aureus*

M. Hashimoto, K. Fukase, Y. Suda, 2009, Journal of Biological Chemistry.

Time-lapse monitoring of TLR2 ligand internalization with newly developed fluorescent probes.

K. Kabayama, K. Fukase, Q. Feng, 2018, Organic & biomolecular chemistry.

Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2

K. Fukase, Y. Nagai, K. Miyake, 2003, The Journal of experimental medicine.

Temporal analysis of localization and trafficking of glycolipids.

K. Kabayama, K. Fukase, Y. Kanie, 2020, Biochemical and biophysical research communications.

Temporal analysis of localization and trafficking of glycolipids

K. Kabayama, K. Fukase, Y. Kanie, 2020, bioRxiv.

Discrimination of cellular developmental states focusing on glycan transformation and membrane dynamics by using BODIPY-tagged lactosyl ceramides.

K. Kabayama, K. Fukase, Yukishige Ito, 2020, Organic & biomolecular chemistry.

Single‐Step Per‐O‐Sulfonation of Sugar Oligomers with Concomitant 1,6‐Anhydro Bridge Formation for Binding Fibroblast Growth Factors

S. Hung, Y. Manabe, K. Fukase, 2018, ChemBioChem.

Oligosaccharide Synthesis on Solid, Soluble Polymer, and Tag Supports

Katsunori Tanaka, K. Fukase, 2011 .

Synthesis of a sialic acid containing complex-type N-glycan on a solid support.

Katsunori Tanaka, K. Fukase, Yasutaka Mori, 2009, Chemistry, an Asian journal.

Direct Guanylation of Amino Groups by Cyanamide in Water: Catalytic Generation and Activation of Unsubstituted Carbodiimide by Scandium(III) Triflate

Katsunori Tanaka, K. Fukase, Kazuki Tsubokura, 2014, Synlett.

Solid‐Phase Synthesis of a Phytoalexin Elicitor Pentasaccharide Using a 4‐Azido‐3‐chlorobenzyl Group as the Key for Temporary Protection and Catch‐and‐Release Purification

K. Fukase, S. Kusumoto, Kenji Egusa, 2003 .

Introduction of 4-Chlorophenyl: A Protecting Group for the Hydroxy Function

K. Fukase, Toshihiro Yamamoto, Yuji Otsuka, 2018, Synlett.

Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus.

K. Fukase, S. Kusumoto, Y. Suda, 2013, Organic & biomolecular chemistry.

A direct continuous spectrophotometric assay for glycosidases with 3-nitro-2-pyridyl glycosides by tautomerization of 2-hydroxy-3-nitropyridine.

Minoru Izumi, K. Fukase, S. Kusumoto, 2002, Analytical biochemistry.

Conformational Study of a Tetraacyl Biosynthetic Precursor of Lipid A by NMR

K. Fukase, S. Kusumoto, M. Oikawa, 2001 .

Chemical Synthesis of Sialyl N-Glycans and Analysis of Their Recognition by Neuraminidase.

Y. Manabe, K. Fukase, A. Molinaro, 2021, Angewandte Chemie.

Synthesis and immunoreactivity of poly(acrylamide) copolymers containing C-3- and C-7-modified, carboxyl-reduced, 4-O- and 5-O-phosphorylated K

K. Fukase, H. Brade, S. Kusumoto, 1993 .

Synthesis of neoglycoproteins containing 5-O-phosphorylated Kdomonosaccharide, 4-O- and 5-O-phosphorylated α-Kd↬(2 6)-2-acetamido-2-deoxy- -D-glucopyranosyl disaccharide residues

K. Fukase, H. Brade, S. Kusumoto, 1996 .

SUGAR SYNTHESIS BY MICROFLUIDIC TECHNIQUES

Katsunori Tanaka, Y. Manabe, K. Fukase, 2016 .

Reinvestigation of the C5-acetamide sialic acid donor for α-selective sialylation: practical procedure under microfluidic conditions.

Katsunori Tanaka, K. Fukase, Masahiro Nagasaki, 2011, Organic & biomolecular chemistry.

Human Peptidoglycan Recognition Protein-L Is an N-Acetylmuramoyl-L-alanine Amidase*

Koichi Fukase, Roman Dziarski, Xinna Li, 2003, Journal of Biological Chemistry.

One-pot synthesis of N-acetyl- and N-glycolylneuraminic acid capped trisaccharides and evaluation of their influenza A(H1 N1) inhibition.

J. Jan, S. Hung, K. Fukase, 2014, Angewandte Chemie.

Synthesis of allyl 3-deoxy-D-manno-2-octulopyranosidic acid 4- and 5-phosphates

K. Fukase, S. Kusumoto, E. Rietschel, 1991 .

Chemical and Enzymatic Synthesis and Production of Glycans

K. Fukase, T. Nokami, H. Ishida, 2019, Glycoscience: Basic Science to Applications.

Synthesis of Peptidoglycan Fragments from Enterococcus faecalis with Fmoc-Strategy for Glycan Elongation.

K. Fukase, Y. Fujimoto, Hiroki Hasegawa, 2017, Chemistry, an Asian journal.

PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics.

Katsunori Tanaka, K. Fukase, 2008, Organic & biomolecular chemistry.

A submicrogram-scale protocol for biomolecule-based PET imaging by rapid 6pi-azaelectrocyclization: visualization of sialic acid dependent circulatory residence of glycoproteins.

Yasuyoshi Watanabe, Katsunori Tanaka, K. Fukase, 2008, Angewandte Chemie.

Oligosaccharide Synthesis by Affinity Separation Based on Molecular Recognition between Podand Ether and Ammonium Ion

Katsunori Tanaka, K. Fukase, S. Kusumoto, 2005 .

Synthesis based on affinity separation (SAS): Separation of products having barbituric acid tag from untagged compounds by using hydrogen bond interaction

Minoru Izumi, K. Fukase, S. Kusumoto, 2001 .

A New Catch-and-Release Purification Method Using a 4-Azido-3-chlorobenzyl Group

K. Fukase, S. Kusumoto, Kenji Egusa, 2001 .

New Efficient Route for Synthesis of Lipid A by using Affinity Separation

K. Fukase, S. Kusumoto, M. Oikawa, 2001 .

New methodology for high throughput solution-phase synthesis: affinity purification by using crown ether and ammonium ion interaction

K. Fukase, S. Kusumoto, San-qi Zhang, 1999 .

A Novel Oxidatively Removable Linker and Its Application to α-Selective Solid-Phase Oligosaccharide Snythesis on a Macroporous Polystyrene Support

K. Fukase, S. Kusumoto, J. A. Porco, 1999 .

4-AZIDO-3-CHLOROBENZYL ETHER, NEW PROTECTION FOR HYDROXY FUNCTIONS

K. Fukase, S. Kusumoto, Kenji Egusa, 1997 .

Renaissance of Traditional Organic Reactions under Microfluidic Conditions: A New Paradigm for Natural Products Synthesis

Koichi Fukase, K. Fukase, Katsunori Tanaka, 2009 .

A New Catch-and-release Purification Method Using a Levulinyl Group as a Tag and Its Application to Oligosaccharide Synthesis

Minoru Izumi, K. Fukase, N. Baba, 2008 .

Recent Advances in the Chemical Biology of N-Glycans

Y. Manabe, K. Fukase, Asuka Shirakawa, 2021, Molecules.

Characterisation of the Dynamic Interactions between Complex N‐Glycans and Human CD22

B. Pagano, Y. Manabe, K. Fukase, 2020, Chembiochem : a European journal of chemical biology.

Glycan‐Mediated Targeting Methods

Katsunori Tanaka, K. Fukase, Kenward Vong, 2020 .

DIVERGENT SYNTHESIS AND BIOLOGICAL ACTIVITIES OF LIPID A ANALOGUES OF SHORTER ACYL CHAINS

K. Fukase, S. Kusumoto, Y. Suda, 1998 .

Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker.

Katsunori Tanaka, K. Fukase, A. Kurbangalieva, 2014, Bioorganic & medicinal chemistry.

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.

Makiko Kobayashi, K. Fukase, Y. Nagai, 2004, International immunology.

Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition.

K. Fukase, Y. Nagai, K. Miyake, 2001, International immunology.

Erratum to “Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies”

K. Fukase, S. Kusumoto, T. Shiba, 2010, Proceedings of the Japan Academy. Series B, Physical and Biological Sciences.

Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structures

K. Fukase, S. Kusumoto, Y. Suda, 2007 .

Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI).

O. Hazeki, K. Fukase, T. Seya, 2007, Biochemical and biophysical research communications.

Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity

K. Fukase, S. Kusumoto, Y. Suda, 2005 .

Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity.

K. Fukase, S. Kusumoto, Y. Suda, 2005, Journal of endotoxin research.

Structural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogs

K. Fukase, S. Kusumoto, Y. Suda, 2003, Journal of endotoxin research.

A Divergent Synthesis of Lipid A and Its Chemically Stable Unnatural Analogues

K. Fukase, S. Kusumoto, Y. Suda, 1999 .

New Efficient Synthesis of a Biosynthetic Precursor of Lipid A

K. Fukase, S. Kusumoto, M. Oikawa, 1997 .

Enzymatic Preparation of (S)-3-Hydroxytetradecanoic Acid and Synthesis of Unnatural Analogues of Lipid A Containing the (S)-Acid

M. Hashimoto, K. Fukase, S. Kusumoto, 1997 .

Structures, synthesis, and human Nod1 stimulation of immunostimulatory bacterial peptidoglycan fragments in the environment.

K. Fukase, Y. Fujimoto, 2011, Journal of natural products.

A Role of Lipophilic Peptidoglycan-related Molecules in Induction of Nod1-mediated Immune Responses*

E. Breukink, G. Núñez, K. Fukase, 2007, Journal of Biological Chemistry.

Chemically synthesized pathogen‐associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll‐like receptors, NOD1 and NOD2 in human oral epithelial cells

Y. Satta, K. Fukase, S. Kusumoto, 2005, Cellular microbiology.

Characterization of Natural Human Nucleotide-binding Oligomerization Domain Protein 1 (Nod1) Ligands from Bacterial Culture Supernatant for Elucidation of Immune Modulators in the Environment*

K. Fukase, N. Inohara, M. Hasegawa, 2010, The Journal of Biological Chemistry.

Differential Release and Distribution of Nod1 and Nod2 Immunostimulatory Molecules among Bacterial Species and Environments*

M. Hashimoto, G. Núñez, K. Fukase, 2006, Journal of Biological Chemistry.

Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo

S. Varambally, A. Chinnaiyan, S. Foster, 2006, The Journal of experimental medicine.

Chemical Synthesis of Peptidoglycan Fragments for Elucidation of the Immunostimulating Mechanism

K. Fukase, S. Kusumoto, Zenyu Shiokawa, 2008 .

to stimulate chemokine production and neutrophil recruitment in vivo

S. Varambally, A. Chinnaiyan, S. Foster, 2006 .

A Comprehensive Study of the Interaction between Peptidoglycan Fragments and the Extracellular Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB

Kentaro Ishii, S. Uchiyama, S. Prisic, 2017, Chembiochem : a European journal of chemical biology.

Microbial glycoconjugates recognition with tlrs and nlrs in innate immunity

K. Fukase, Y. Fujimoto, 2015 .

Chemical N-Glycosylation byAsparagine under Integrated Microfluidic/Batch Conditions

Katsunori Tanaka, K. Fukase, T. Miyagawa, 2009 .

Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step.

Shin-ichi Tanaka, Katsunori Tanaka, Koichi Fukase, 2007, Organic letters.

Efficient Procedure for Reductive Opening of Sugar 4,6-O-Benzylidene Acetals in a Microfluidic System

Katsunori Tanaka, K. Fukase, 2007 .

Autophagic control of listeria through intracellular innate immune recognition in drosophila

R. Ueda, W. Goldman, K. Fukase, 2008, Nature Immunology.

Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses.

K. Fukase, H. Tsutsui, A. Saeki, 2013, Molecular bioSystems.

Chemical synthesis of bacterial lipid A

K. Fukase, S. Kusumoto, Y. Fujimoto, 2010 .

Lipid A-Mediated Bacterial–Host Chemical Ecology: Synthetic Research of Bacterial Lipid As and Their Development as Adjuvants

K. Fukase, A. Shimoyama, 2021, Molecules.

Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine

H. Kiyono, K. Fukase, T. Nagatake, 2020, Vaccines.

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

Koichi Fukase, Toshiyuki Shimizu, Toshiyuki Shimizu, 2012, Proceedings of the National Academy of Sciences.

Crystal Structures of Human MD-2 and Its Complex with Antiendotoxic Lipid IVa

Y. Satow, K. Fukase, K. Miyake, 2007, Science.

Regulatory Roles for MD-2 and TLR4 in Ligand-Induced Receptor Clustering1

Makiko Kobayashi, K. Fukase, K. Miyake, 2006, The Journal of Immunology.

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.

B. Monks, D. Golenbock, H. Heine, 2000, The Journal of clinical investigation.

A Dominant Role of Toll-Like Receptor 4 in the Signaling of Apoptosis in Bacteria-Faced Macrophages 1

J. Heesemann, A. Sing, K. Fukase, 2003, The Journal of Immunology.

Macrophages the Signaling of Apoptosis in Bacteria-Faced A Dominant Role of Toll-Like Receptor 4 in

J. Heesemann, A. Sing, K. Fukase, 2003 .

Lipopolysaccharide Derived From the Lymphoid-Resident Commensal Bacteria Alcaligenes faecalis Functions as an Effective Nasal Adjuvant to Augment IgA Antibody and Th17 Cell Responses

H. Kiyono, K. Fukase, T. Nagatake, 2021, Frontiers in Immunology.

TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells.

K. Ishii, H. Kiyono, K. Fukase, 2023, International immunopharmacology.

Lanthiopeptin, a new peptide effective against herpes simplex virus: structural determination and comparison with Ro 09-0198, an immunopotentiating peptide

K. Fukase, M. Konishi, T. Shiba, 1988 .

Discovery of a Novel Scaffold as an Indoleamine 2,3‐Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B

Koichi Fukase, Yukari Fujimoto, K. Fukase, 2016, ChemMedChem.

Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines.

K. Fukase, A. Uehara, H. Takada, 2007, Molecular immunology.

Ligand-Induced Receptor Clustering Regulatory Roles for MD2 and TLR 4 in and Kensuke

Makiko Kobayashi, K. Fukase, K. Miyake, 2006 .

Molecular basis for bacterial peptidoglycan recognition by LysM domains

S. Foster, S. Lacroix-Desmazes, J. Dimitrov, 2014, Nature Communications.

Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity

H. Kiyono, K. Fukase, T. Nagatake, 2020, Microorganisms.

Energetics of lipid transport by the ABC transporter MsbA is lipid dependent

D. Spring, K. Fukase, Yakun Tang, 2021, Communications Biology.

Astatine-211-Labeled Gold Nanoparticles for Targeted Alpha-Particle Therapy via Intravenous Injection

K. Kabayama, K. Fukase, A. Toyoshima, 2022, Pharmaceutics.

Syntheses and functional studies of self-adjuvanting anti-HER2 cancer vaccines.

Taku Aiga, Y. Manabe, K. Kabayama, 2019, Chemistry, an Asian journal.

Syntheses and Immunological Evaluation of Self-Adjuvanting Clustered N-Acetyl and N-Propionyl Sialyl-Tn Combined with a T-helper Cell Epitope as Antitumor Vaccine Candidates.

Y. Manabe, Tsung-Che Chang, K. Kabayama, 2018, Angewandte Chemie.

Behavior of glycolylated sialoglycans in the binding pockets of murine and human CD22

M. Civera, S. Sattin, Y. Manabe, 2020, iScience.

Pyrazolo[4,3-d]pyrimidine Derivatives as a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Inhibitor for the Treatment of Anemia.

K. Fukase, Y. Takada, R. Ohashi, 2020, ACS medicinal chemistry letters.

WaaA of the Hyperthermophilic Bacterium Aquifex aeolicus Is a Monofunctional 3-Deoxy-d-manno-oct-2-ulosonic Acid Transferase Involved in Lipopolysaccharide Biosynthesis*

R. Hilgenfeld, J. Mesters, Timothy C. Meredith, 2009, The Journal of Biological Chemistry.

Highly Efficient Coupling of Unstable Bicyclic Pyrimidines and Pyrazoles under Basic Conditions, and its Application to the Synthesis of Pharmaceutical Compounds

K. Fukase, Takashi Goi, 2018, Synlett.

A Divergent Synthesis of Lipid A and Its Chemically Stable Unnatural Analogues.

K. Fukase, S. Kusumoto, Y. Suda, 1999 .

A typical bacterial ornithine-containing lipid Nalpha-(D)-[3-(hexadecanoyloxy)hexadecanoyl]-ornithine is a strong stimulant for macrophages and a useful adjuvant.

K. Fukase, S. Kusumoto, Y. Kawai, 1999, FEMS immunology and medical microbiology.

Detection of UDP-D-xylose: alpha-D-xyloside alpha 1-->3xylosyltransferase activity in human hepatoma cell line HepG2.

K. Fukase, S. Kusumoto, S. Natsuka, 1996, Journal of Biochemistry (Tokyo).

In Silico Analysis and Experimental Evaluation of Ester Prodrugs of Ketoprofen for Oral Delivery: With a View to Reduce Toxicity

Md. Abdullah Aziz, K. Fukase, M. Mohiuddin, 2021, Processes.

Traceless solid-phase synthesis of multiple sulfonamide-containing cyclic sulfides exploiting microwave irradiation

K. Fukase, K. Saruta, T. Ogiku, 2009 .

Novel Dehydrative Glycosylation by Using Acid Anhydride and TMSClO4

Masahiro Wakao, K. Fukase, S. Kusumoto, 1999 .

Evaluation of Astatine-211-Labeled Fibroblast Activation Protein Inhibitor (FAPI): Comparison of Different Linkers with Polyethylene Glycol and Piperazine

T. Watabe, F. Giesel, K. Fukase, 2023, International Journal of Molecular Sciences.

Effect to Therapy of Sodium-Iodine Symporter Expression by Alpha-Ray Therapeutic Agent via Sodium/Iodine Symporter

T. Watabe, K. Fukase, A. Toyoshima, 2022, International Journal of Molecular Sciences.

Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies".

K. Fukase, S. Kusumoto, T. Shiba, 2010, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A

H. Kiyono, K. Kabayama, K. Fukase, 2021, Angewandte Chemie.

Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection

K. Fukase, Shinji Tanaka, E. Tannich, 2017, Scientific Reports.

Highly Efficient Sialylation towards α(2-3)- and α(2-6)-Neu5Ac-Gal Synthesis: Significant ‘Fixed Dipole Effect’ of N-Phthalyl Group on α-Selectivity

Katsunori Tanaka, K. Fukase, Takashi Goi, 2005 .

TMSCl as a Mild and Effective Source of Acidic Catalysis in Fischer Glycosidation and Use of Propargyl Glycoside for Anomeric Protection

Minoru Izumi, K. Fukase, S. Kusumoto, 2002, Bioscience, biotechnology, and biochemistry.

Meso-diaminopimelic acid and meso-lanthionine, amino acids peculiar to bacterial cell-wall peptidoglycans, activate human epithelial cells in culture via NOD1

K. Fukase, A. Uehara, H. Takada, 2007 .

Crystal structure of human MD-2 in complex with lipid IVa

Y. Satow, K. Fukase, K. Miyake, 2007 .

Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions

K. Fukase, N. Inohara, M. Hasegawa, 2009 .

Toll-like Receptors, NOD1, and NOD2 in Oral Epithelial Cells

K. Fukase, K. Shibata, S. Kusumoto, 2006, Journal of dental research.

Self and nonself recognition with bacterial and animal glycans, surveys by synthetic chemistry.

Katsunori Tanaka, K. Fukase, Y. Fujimoto, 2010, Methods in enzymology.

Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.

H. Kawaguchi, K. Fukase, M. Konishi, 1989, The Journal of antibiotics.

Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling

K. Fukase, K. Miyake, S. Kusumoto, 2004, Journal of endotoxin research.

Narrower HOMO-LUMO gap attained by conformational switching through peripheral polyarylation in 1,4,5,8-tetraaza-9,10-anthraquinodimethanes

T. Fukushima, Y. Manabe, K. Fukase, 2018 .

Synthesis of an analog of biosynthetic precursor Ia of lipid A by an improved method: a novel antagonist containing four (S)-3-hydroxy fatty acids

K. Fukase, E. Rietschel, S. Kusumoto, 1995 .

Synthetic Chemistry and Function of Bacterial Cell Surface Glycoconjugates

K. Fukase, S. Kusumoto, Y. Suda, 2002 .

Construction of the systemic anticancer immune environment in tumour-bearing humanized mouse by using liposome-encapsulated anti-programmed death ligand 1 antibody-conjugated progesterone

T. Shiina, M. Tokeshi, Masatoshi Maeki, 2023, Frontiers in immunology.

Antigen/Adjuvant-Displaying Enveloped Viral Replica as a Self-Adjuvanting Anti-Breast-Cancer Vaccine Candidate.

M. Tokeshi, Masatoshi Maeki, Y. Manabe, 2023, Journal of the American Chemical Society.

Toll-like Receptors, NOD1, and NOD2 in Oral Epithelial Cells

K. Fukase, K. Shibata, S. Kusumoto, 2006 .

Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis

R. Hilgenfeld, J. Mesters, O. Holst, 2012, Proceedings of the National Academy of Sciences.

Dysoticans F–H: three unprecedented dimeric cadinanes from Dysoxylum parasiticum (Osbeck) Kosterm. stem bark

Y. Manabe, K. Kabayama, K. Fukase, 2023, RSC Advances.

Expression of various Toll-like receptors, NOD1, and NOD2, in human oral epithelial cells, and their function

K. Fukase, T. Sasano, A. Uehara, 2007 .

Regioselective Reductive Opening of 4,6-O-Benzylidene Acetals of Glucose or Glucosamine Derivatives by BH3⋅Me2NH - BF3⋅OEt2

K. Fukase, S. Kusumoto, M. Oikawa, 1996 .

Structural Characterization of Neutral and Acidic Glycolipids from Thermus thermophilus HB8

S. Kuramitsu, K. Fukase, S. Kusumoto, 2012, PloS one.

LPS-dependent changes in the expression of 57 kDa and 53 kDa cell membrane proteins without participation of CD14

T. Kirikae, K. Fukase, F. Kirikae, 1999 .

A Dominant Role of Toll-Like Receptor 4 in the Signaling of Apoptosis in Bacteria-Faced Macrophages

J. Heesemann, A. Sing, K. Fukase, 2003 .

Bio-imaging and cancer targeting with glycoproteins and N-glycans.

Katsunori Tanaka, K. Fukase, 2012, Current opinion in chemical biology.

SYNTHETIC STUDY ON PEPTIDE ANTIBIOTIC NISIN. I. THE SYNTHESIS OF RING A

K. Fukase, A. Sano, T. Shiba, 1983 .

Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo

S. Varambally, A. Chinnaiyan, S. Foster, 2006, The Journal of experimental medicine.

Pyrazolo[4,3-d]pyrimidine Derivatives as a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Inhibitor for the Treatment of Anemia.

K. Fukase, Y. Takada, R. Ohashi, 2020, ACS medicinal chemistry letters.

Synthesis of Peptidoglycan Fragments from Enterococcus faecalis with Fmoc-Strategy for Glycan Elongation.

K. Fukase, Y. Fujimoto, Hiroki Hasegawa, 2017, Chemistry, an Asian journal.

A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cells.

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2014, Organic & biomolecular chemistry.

This information is current as Activation Monoacylated MDP Confers TLR 2 / TLR 4 Muramyl Dipeptide ( MDP ) Derivatives : Dendritic Cell Maturation Induced by Shoichi Kusumoto and Tsukasa Seya

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