A. Schön

发表

Bioinspired supramolecular engineering of self-assembling immunofibers for high affinity binding of immunoglobulin G.

Xuankuo Xu, Sanchayita Ghose, Shih-Hao Ou, 2018, Biomaterials.

Crystal structure , conformational fixation , and entry-related interactions of mature ligand-free HIV-1 Env

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2016 .

Thermodynamics-based drug design: strategies for inhibiting protein-protein interactions.

E. Freire, A. Schön, S. Y. Lam, 2011, Future medicinal chemistry.

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

R. Lamb, W. DeGrado, L. Pinto, 2009, Proceedings of the National Academy of Sciences.

Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.

Alexander W. Sun, J. Sodroski, J. Mascola, 2012, Journal of medicinal chemistry.

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

J. Mullikin, J. Mascola, Yicheng Guo, 2019, Cell.

A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike

Tongqing Zhou, Baoshan Zhang, Richard A. Friesner, 2020, bioRxiv : the preprint server for biology.

Multidrug resistance to HIV-1 protease inhibition requires cooperative coupling between distal mutations.

E. Freire, A. Schön, Arne Schön, 2003, Biochemistry.

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo.

Xiaoqun Gong, Justin Hanes, Qingguo Xu, 2015, ACS nano.

Inhibiting Early-Stage Events in HIV-1 Replication by Small-Molecule Targeting of the HIV-1 Capsid

R. Ptak, J. Sodroski, F. Krebs, 2012, Journal of Virology.

Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein

A. Schön, R. Seder, Neville K. Kisalu, 2021, PLoS pathogens.

Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization.

J. Sodroski, J. Mascola, Judith M. LaLonde, 2013, ACS medicinal chemistry letters.

Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18.

D. Dimitrov, J. Gershoni, E. Freire, 2011, Biochemistry.

Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120.

E. Freire, A. Schön, J. C. Klein, 2009, Biochemistry.

Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.

J. Sodroski, R. Wyatt, Judith M. LaLonde, 2008, Structure.

Long term stability of a HIV-1 neutralizing monoclonal antibody using isothermal calorimetry.

E. Freire, A. Schön, L. Kueltzo, 2018, Analytical biochemistry.

Temperature stability of proteins: Analysis of irreversible denaturation using isothermal calorimetry

E. Freire, A. Schön, Benjamin R Clarkson, 2017, Proteins.

Isothermal titration calorimetry: general formalism using binding polynomials.

A. Velázquez‐Campoy, E. Freire, A. Schön, 2009, Methods in enzymology.

Chapter 5 Isothermal Titration Calorimetry

A. Velázquez‐Campoy, E. Freire, A. Schön, 2009 .

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Alon Herschhorn, J. Sodroski, J. Mascola, 2019, Nature Communications.

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Alon Herschhorn, J. Sodroski, J. Mascola, 2019, Nature Communications.

A human monoclonal antibody prevents malaria infection and defines a new site of vulnerability on Plasmodium falciparum circumsporozoite protein

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

J. Mullikin, J. Mascola, Yicheng Guo, 2019, Cell.

Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2

M. Pazgier, C. Abrams, J. Richard, 2021, bioRxiv.

Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies

E. Freire, A. Schön, Y. Hayashi, 2013, European Journal of Medicinal Chemistry.

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study

E. Freire, A. Schön, Y. Kiso, 2013, European Journal of Medicinal Chemistry.

The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

M. Pancera, A. Schön, R. Seder, 2021, bioRxiv.

Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity.

D. Vézina, M. Pazgier, C. Abrams, 2019, ACS medicinal chemistry letters.

Strategies for targeting HIV-1 envelope glycoprotein gp120 in the development of new antivirals

E. Freire, A. Schön, 2007 .

Highly protective antimalarial antibodies via precision library generation and yeast display screening

Reda Rawi, Chen-Hsiang Shen, Baoshan Zhang, 2022, The Journal of experimental medicine.

Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen

J. Mascola, G. Chuang, Reda Rawi, 2020, Scientific Reports.

Antiproliferative response of human leukemic cells: lectin induced inhibition of DNA synthesis and cellular metabolism.

C. Borrebaeck, A. Schön, 1987, Cancer research.

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

J. Mascola, M. Sastry, Reda Rawi, 2022, Structure.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

Binding Thermodynamics of a Small-Molecular-Weight CD4 Mimetic to HIV-1 gp120

J. Sodroski, E. Freire, Amos B. Smith, 2008 .

Development of high-af ﬁ nity nanobodies speci ﬁ c for Na V 1.4 and Na V 1.5 voltage-gated sodium channel isoforms

G. Tomaselli, L. Amzel, E. Freire, 2022 .

Enthalpy screen of drug candidates.

E. Freire, A. Schön, 2016, Analytical biochemistry.

Antibody-induced apoptosis in a human leukemia cell line is energy dependent: thermochemical analysis of cellular metabolism.

C. Borrebaeck, A. Schön, P. Lönnbro, 1993, Cancer letters.

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

J. Mascola, M. Sastry, Reda Rawi, 2022, bioRxiv.

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

R. Friesner, D. Ho, J. Mascola, 2020, Cell Host & Microbe.

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

J. Yates, T. Schroer, E. Freire, 2013, Molecular biology of the cell.

Targeting the pregnane X receptor using microbial metabolite mimicry

S. Vishveshwara, S. Kortagere, M. Redinbo, 2019, bioRxiv.

Ligand binding analysis and screening by chemical denaturation shift.

Burleigh M. Hutchins, E. Freire, A. Schön, 2013, Analytical biochemistry.

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.

Jorgen W. Nelson, D. Baker, R. Gottardo, 2020, Immunity.

The binding of HIV-1 protease inhibitors to human serum proteins.

E. Freire, A. Schön, Maria del Mar Ingaramo, 2003, Biophysical chemistry.

Photochemical control of RNA structure by disrupting π-stacking.

E. Freire, A. Schön, Marino J. E. Resendiz, 2012, Journal of the American Chemical Society.

Development of high-affinity nanobodies specific for NaV1.4 and NaV1.5 voltage-gated sodium channel isoforms

G. Tomaselli, L. Amzel, E. Freire, 2022, The Journal of biological chemistry.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

Crystal structures of trimeric HIV Env with entry inhibitors BMS-378806 and BMS-626529

Alon Herschhorn, J. Sodroski, J. Mascola, 2017, Nature chemical biology.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

R. Friesner, D. Ho, J. Mascola, 2020, bioRxiv.

CD4 mimetics sensitize HIV-1-infected cells to ADCC

J. Sodroski, B. Haynes, D. Kaufmann, 2015, Proceedings of the National Academy of Sciences.

Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2

M. Pazgier, C. Abrams, J. Richard, 2021, Journal of Biological Chemistry.

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

R. Baric, G. Chuang, P. Kwong, 2020, NPJ vaccines.

Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins.

E. Freire, A. Schön, B. Wendland, 2006, Proceedings of the National Academy of Sciences of the United States of America.

HIV-1 Vif N-terminal Motif is required for recruitment of Cul5 to Suppress APOBEC3

Xiaohong Zhou, Sean L. Evans, Xiaohong Zhou, 2014, Retrovirology.

Soluble Mimetics of Human Immunodeficiency Virus Type 1 Viral Spikes Produced by Replacement of the Native Trimerization Domain with aHeterologous Trimerization Motif: Characterization and Ligand Binding Analysis

J. Sodroski, R. Wyatt, E. Freire, 2005, Journal of Virology.

Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.

J. Sodroski, Judith M. LaLonde, W. Hendrickson, 2016, ACS medicinal chemistry letters.

Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets.

A. Velázquez‐Campoy, E. Freire, S. Vega, 2004, The international journal of biochemistry & cell biology.

Thermodynamics of intersubunit interactions in cholera toxin upon binding to the oligosaccharide portion of its cell surface receptor, ganglioside GM1.

E. Freire, E. Freire, A. Schön, 1989, Biochemistry.

Anti-Prionin IgG, Possible new Serum Markers for Contact and Infection with Transmissible Spongiform Encephalopathies: Preliminary Results from Screening 100 Blood Donors

A. Schön, P. Kühnl, K. Gutensohn, 2004 .

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

J. Mascola, M. Sastry, Reda Rawi, 2022, Structure.

Reversibility and Irreversibility in the Temperature Denaturation of Monoclonal Antibodies.

E. Freire, A. Schön, 2021, Analytical biochemistry.

Conformational stability and self-association equilibrium in biologics.

E. Freire, A. Schön, Benjamin R Clarkson, 2016, Drug discovery today.

Chemical denaturation as a tool in the formulation optimization of biologics.

Burleigh M. Hutchins, E. Freire, A. Schön, 2013, Drug discovery today.

Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

M. Asokan, A. Pegu, A. Schön, 2020, JCI insight.

Non‐natural Peptide Triazole Antagonists of HIV‐1 Envelope gp120

Mark Contarino, E. Freire, I. Chaiken, 2013, ChemMedChem.

Use of the quartz crystal microbalance to monitor ligand-induced conformational rearrangements in HIV-1 envelope protein gp120

E. Freire, I. Chaiken, Amos B. Smith, 2010, Analytical and bioanalytical chemistry.

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env

U. Baxa, J. Mascola, G. Chuang, 2015, Journal of Virology.

Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.

G. Chuang, K. Kirsch, Reda Rawi, 2021, Immunity.

Three easy pieces.

E. Freire, A. Schön, 2016, Biochimica et biophysica acta.

Structural and thermodynamic basis of resistance to HIV-1 protease inhibition: implications for inhibitor design.

A. Velázquez‐Campoy, E. Freire, S. Vega, 2003, Current drug targets. Infectious disorders.

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.

Joel S. Freundlich, D. Rice, C. Fishwick, 2013, Biochemistry.

Binding Thermodynamics to Intrinsically Disordered Protein Domains.

E. Freire, A. Schön, 2020, Methods in molecular biology.

Methods for Structural Analysis of Protein Pharmaceuticals (Jiskoot, W. and Crommelin, D.J.A., Eds.) Arlington, VA, AAPS Press; 2005: 573-589. Methods for Structural Analysis of Protein Pharmaceuticals (Jiskoot, W. and Crommelin, D.J.A., Eds.) Arlington, VA, AAPS Press; 2005: 573-589.

A. Velázquez‐Campoy, A. Schön, 2005 .

Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.

J. Sodroski, E. Freire, I. Chaiken, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Alon Herschhorn, Christopher Gu, J. Sodroski, 2017, Nature Communications.

Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain

J. Sodroski, E. Freire, P. Kwong, 2009, Journal of Virology.

Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency

J. Mascola, Reda Rawi, Baoshan Zhang, 2023, mAbs.

Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody

G. Chuang, Reda Rawi, Z. Sheng, 2021, Proceedings of the National Academy of Sciences.

CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies

H. Liao, J. Sodroski, B. Haynes, 2014, Journal of Virology.

Small-Molecule CD 4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp 120

J. Sodroski, R. Wyatt, Judith M. LaLonde, 2018 .

Functional human IgA targets a conserved site on malaria sporozoites

Peter D. Crompton, I. Wilson, P. Sinnis, 2021, Science Translational Medicine.

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

J. Mascola, M. Sastry, Reda Rawi, 2022, Structure.

Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.

J. Sodroski, F. Krebs, Judith M. LaLonde, 2008, Journal of medicinal chemistry.

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Alon Herschhorn, J. Sodroski, J. Mascola, 2019, Nature Communications.

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species

S. Prigge, E. Freire, A. Schön, 2017, Molecular microbiology.

SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement

Alon Herschhorn, Luis R. Castillo-Menendez, J. Sodroski, 2018, Journal of Virology.

Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection

A. Schön, R. Seder, R. Amino, 2023, Cell reports.

Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

Peter D. Kwong, Wayne A. Hendrickson, Joel R. Courter, 2014, Accounts of chemical research.

Vaccine elicitation and structural basis for antibody protection against alphaviruses

Chaim A. Schramm, S. Pletnev, D. Ambrozak, 2023, Cell.

The Active Core in a Triazole Peptide Dual‐Site Antagonist of HIV‐1 gp120

Judith M. LaLonde, E. Freire, I. Chaiken, 2010, ChemMedChem.

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.

Young Do Kwon, Joel R Courter, Peter D Kwong, 2011, Bioorganic & medicinal chemistry.

In Silico Improvement of Highly Protective Anti-Malarial Antibodies

Reda Rawi, Chen-Hsiang Shen, Baoshan Zhang, 2022, bioRxiv.

Cleavage of recombinant and cell derived human immunodeficiency virus 1 (HIV‐1) Nef protein by HIV‐1 protease

A. Schön, V. Erfle, G. Wachinger, 1995, FEBS letters.

A human monoclonal antibody prevents malaria infection and defines a new site of vulnerability on Plasmodium falciparum circumsporozoite protein

Alex B. Miller, S. Hoffman, H. Liao, 2018 .

Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

J. Sodroski, E. Freire, A. Schön, 2006, Biochemistry.

Judith M. LaLonde, E. Freire, Amos B. Smith, 2011, Chemical biology & drug design.

Optimization of CD4/gp120 Inhibitors by Thermodynamic‐Guided Alanine‐Scanning Mutagenesis

E. Freire, A. Schön, Yingyun Liu, 2013, Chemical biology & drug design.

Isothermal titration calorimetry: general formalism using binding polynomials.

A. Velázquez‐Campoy, E. Freire, A. Schön, 2009, Methods in enzymology.

Crystal structure, conformational fixation, and entry-related interactions of mature ligand-free HIV-1 Env

James B. Munro, Daniel S. Terry, Cinque S. Soto, 2015, Nature Structural &Molecular Biology.

Publisher Correction: The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Alon Herschhorn, Christopher Gu, J. Sodroski, 2018, Nature Communications.

Denatured state aggregation parameters derived from concentration dependence of protein stability.

E. Freire, A. Schön, Arne Schön, 2015, Analytical biochemistry.

Bioinspired supramolecular engineering of self-assembling immunofibers for high affinity binding of immunoglobulin G.

E. Freire, Z. Li, H. Cui, 2018, Biomaterials.

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo.

E. Freire, A. Schön, J. Hanes, 2015, ACS nano.

Characterisation of ligand binding by calorimetry

A. Velázquez‐Campoy, E. Freire, A. Schön, 2011 .

CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies

J. Sodroski, B. Haynes, R. Wyatt, 2014, Journal of Virology.

Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site

J. Mascola, G. Chuang, M. Sastry, 2023, Nature communications.