G. Fields

M. Giulianotti, R. Houghten, G. Fields, 2020, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Peptides as Models for Understanding Protein Folding

G. Fields, K. Mayo, 1997 .

Promotion of cell adhesion by single-stranded and triple-helical peptide models of basement membrane collagen alpha 1(IV)531-543. Evidence for conformationally dependent and conformationally independent type IV collagen cell adhesion sites.

A. Skubitz, G. Fields, A. Miles, 1994, The Journal of biological chemistry.

A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis.

D. King, G. Fields, C. Fields, 1990, International journal of peptide and protein research.

Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics

A. Metters, J. Hubbell, G. Fields, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The development of high-performance liquid chromatographic analysis of allyl and allyloxycarbonyl side-chain-protected phenylthiohydantoin amino acids.

G. Fields, C. Fields, S. Kates, 1992, Analytical biochemistry.

Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution.

M. Lindsey, G. Fields, R. Iyer, 2016, Journal of molecular and cellular cardiology.

Evaluation of radiolabeled type IV collagen fragments as potential tumor imaging agents.

M. Welch, G. Fields, C. Anderson, 2001, Bioconjugate chemistry.

TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution

G. Fields, M. Cudic, Forrest G. FitzGerald, 2020, Glycoconjugate Journal.

Creating functional collagen peptide architectures on solid surfaces

S. Satija, H. Bianco-Peled, M. Tirrell, 2002 .

Defining the domains of type I collagen involved in heparin- binding and endothelial tube formation.

Shawn M. Sweeney, G. Fields, S. Sweeney, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Differential Modulation of Human Melanoma Cell Metalloproteinase Expression by α2β1 Integrin and CD44 Triple-helical Ligands Derived from Type IV Collagen*

G. Fields, J. Borgia, D. Baronas-Lowell, 2004, Journal of Biological Chemistry.

Discovery of Novel Inhibitors of a Disintegrin and Metalloprotease 17 (ADAM17) Using Glycosylated and Non-glycosylated Substrates*

M. Giulianotti, R. Houghten, Nina Bionda, 2012, The Journal of Biological Chemistry.

Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly.

Shawn M. Sweeney, R. Iozzo, G. Fields, 2003, The Journal of biological chemistry.

Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma–Induced Osteolysis and Reduces Overall Survival

G. Fields, W. Roush, K. Shain, 2021, Cancer Research.

The synthesis and application of Fmoc-Lys(5-Fam) building blocks.

G. Fields, Michal Tokmina-Roszyk, Dorota Tokmina-Roszyk, 2013, Biopolymers.

Collagen in Cancer

G. Fields, J. Lauer, 2010 .

An all-D amino acid peptide model of α1(IV)531-543 from type IV collagen binds the α3β1 integrin and mediates tumor cell adhesion, spreading, and motility

G. Fields, J. McCarthy, L. Furcht, 1997 .

Stabilization of collagen-model, triple-helical peptides for in vitro and in vivo applications.

G. Fields, Manishabrata Bhowmick, 2013, Methods in molecular biology.

Hyperhydroxylation: a new strategy for neuronal targeting by venomous marine molluscs.

G. Fields, F. Marí, C. Möller, 2006, Progress in molecular and subcellular biology.

Matrix metalloproteinase inhibitors and cancer

G. Fields, Janelle L. Lauer-Fields, 2000 .

Contributions of the MMP-2 collagen binding domain to gelatin cleavage. Substrate binding via the collagen binding domain is required for hydrolysis of gelatin but not short peptides.

G. Fields, Xiaoping Xu, Janelle L. Lauer-Fields, 2004, Matrix biology : journal of the International Society for Matrix Biology.

Substrate Conformation Modulates Aggrecanase (ADAMTS-4) Affinity and Sequence Specificity

M. Kashiwagi, G. Fields, H. Nagase, 2007, Journal of Biological Chemistry.

Trifluoroacetic acid cleavage and deprotection of resin-bound peptides following synthesis by Fmoc chemistry.

G. Fields, C. A. Guy, 1997, Methods in enzymology.

Promotion of Fibroblast Adhesion by Triple-helical Peptide Models of Type I Collagen-derived Sequences (*)

G. Fields, A. Miles, L. Furcht, 1996, The Journal of Biological Chemistry.

Targeted drug delivery utilizing protein-like molecular architecture.

G. Fields, M. Cudic, D. Baronas-Lowell, 2007, Journal of the American Chemical Society.

Peptides for the New Millennium

Gregg B. Fields, James P. Tam, J. Tam, 2002, American Peptide Symposia.

Purification and analysis of synthetic, triple-helical "minicollagens" by reversed-phase high-performance liquid chromatography.

G. Fields, C. Fields, J. Lauer, 1995, Analytical biochemistry.

Generally applicable, convenient solid-phase synthesis and receptor affinities of octreotide analogs.

M. Welch, G. Fields, C. Anderson, 1994, Journal of medicinal chemistry.

Solid‐phase synthesis, characterization, and cellular activities of collagen‐model Nanodiamond‐peptide conjugates

Andrew C. Terentis, Y. Gogotsi, V. Mochalin, 2015, Biopolymers.

The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.

K. Pradhan, J. Sosman, Douglas B. Johnson, 2018, JCI insight.

Peptide-mediated targeting of liposomes to tumor cells.

R. Tu, M. Tirrell, G. Fields, 2007, Methods in molecular biology.

The normalization of gene expression data in melanoma: Investigating the use of GAPDH and 18S rRNA as internal reference genes for quantitative real-time PCR

G. Fields, Janelle L. Lauer-Fields, Orsolya Giricz, 2008 .

Extracellular proteases as targets for drug development.

G. Fields, M. Cudic, 2009, Current protein & peptide science.

Six-year study of peptide synthesis.

R. Angeletti, L. Bonewald, G. Fields, 1997, Methods in enzymology.

Use of Supported Thin Films of Peptide Amphiphiles as Model Systems of the Extracellular Matrix to Study the Effects of Structure– Function Phenomena on Cell Adhesion

M. Tirrell, G. Fields, A. K. Dillow, 2002 .

Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo.

G. Fields, Jamee Bresee, W. B. Edwards, 2012, Bioorganic & medicinal chemistry letters.

Determining the Substrate Specificity of Matrix Metalloproteases using Fluorogenic Peptide Substrates.

G. Fields, A. Knapinska, M. Stawikowski, 2017, Methods in molecular biology.

Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the α2β1-integrin receptor

R. Iozzo, G. Fields, A. McQuillan, 2007 .

Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor.

R. Iozzo, G. Fields, A. McQuillan, 2007, Blood.

Solid-Phase Peptide Synthesis

G. Fields, 1998 .

A Peptide Model of Basement Membrane Collagen α 1(IV) 531- 543 Binds the α3β1 Integrin (*)

A. Skubitz, G. Fields, J. McCarthy, 1995, The Journal of Biological Chemistry.

A peptide model of basement membrane collagen alpha 1 (IV) 531-543 binds the alpha 3 beta 1 integrin.

A. Skubitz, G. Fields, J. McCarthy, 1995, The Journal of biological chemistry.

Backbone and side‐chain dynamics of residues in a partially folded β‐sheet peptide from platelet factor‐4

G. Fields, K. Mayo, E. Ilyina, 1997, Protein science : a publication of the Protein Society.

The Roles of Matrix Metalloproteinases in Pancreatic Cancer.

G. Fields, A. Knapinska, Christie-Anne Estrada, 2017, Progress in molecular biology and translational science.

CD44/chondroitin sulfate proteoglycan and alpha 2 beta 1 integrin mediate human melanoma cell migration on type IV collagen and invasion of basement membranes.

G. Fields, J. Iida, J. McCarthy, 1996, Molecular biology of the cell.

A novel conotoxin framework with a helix-loop-helix (Cs α/α) fold

G. Fields, J. Bubis, F. Marí, 2005 .

A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold.

G. Fields, J. Bubis, F. Marí, 2005, Biochemistry.

Polypeptide chains containing D-gamma-hydroxyvaline.

G. Fields, F. Marí, K. Pisarewicz, 2005, Journal of the American Chemical Society.

Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle.

M. Lindsey, S. Weintraub, G. Fields, 2014, Antioxidants & redox signaling.

Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide

M. Selsted, A. Ouellette, G. Fields, 2017, PloS one.

Variability in melanoma metalloproteinase expression profiling.

G. Fields, J. Lauer, Orsi Giricz, 2010, Journal of biomolecular techniques : JBT.

Screening of potential ADAMTS-4 inhibitors utilizing a collagen- model FRET substrate

T. Spicer, G. Fields, P. Hodder, 2008 .

The Expanding Role of MT1-MMP in Cancer Progression

G. Fields, A. Knapinska, 2019, Pharmaceuticals.

Fatty acylated toxin structure

G. Fields, L. Bowers, W. Branton, 1993, Nature.

In vitro incorporation of synthetic peptides into cells.

G. Fields, J. Lauer, 1997, Methods in enzymology.

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

Mitchell D. Miller, G. Phillips, J. Tainer, 2021, Communications biology.

Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β

T. Spicer, G. Fields, P. Hodder, 2014, Biopolymers.

AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein α.

Hongjie Wang, G. Fields, A. Nefzi, 2014, Analytical biochemistry.

Identification of the 183RWTNNFREY191Region as a Critical Segment of Matrix Metalloproteinase 1 for the Expression of Collagenolytic Activity*

D. Dinakarpandian, G. Fields, K. Shimokawa, 2000, The Journal of Biological Chemistry.

Development of a solid-phase assay for analysis of matrix metalloproteinase activity.

G. Fields, H. Nagase, Janelle L. Lauer-Fields, 2004, Journal of biomolecular techniques : JBT.

Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia.

H. Rossiter, G. Fields, A. V. Khamoui, 2020, Physiological genomics.

Solid phase peptide synthesis of 15N-gramicidins A, B, and C and high performance liquid chromatographic purification.

G. Fields, R. Noble, T. Cross, 2009, International journal of peptide and protein research.

Synthesis of Fmoc-Gly-Ile Phosphinic Pseudodipeptide: Residue Specific Conditions for Construction of Matrix Metalloproteinase Inhibitor Building Blocks

G. Fields, Manishabrata Bhowmick, 2012, International Journal of Peptide Research and Therapeutics.

Exosite Interactions Impact Matrix Metalloproteinase Collagen Specificities*

G. Fields, B. Steffensen, Trista K. Robichaud, 2011, The Journal of Biological Chemistry.

Efficient synthesis of Fmoc‐protected phosphinic pseudodipeptides: Building blocks for the synthesis of matrix metalloproteinase inhibitors

G. Fields, Salvatore D. Lepore, Manishabrata Bhowmick, 2011, Biopolymers.

Modulation of receptor binding to collagen by glycosylated 5‐hydroxylysine: Chemical biology approaches made feasible by Carpino's Fmoc group

G. Fields, M. Cudic, 2020, Peptide science.

Variable Success of Peptide-Resin Cleavage and Deprotection Following Solid-Phase Synthesis

L. C. Williams, S. Carr, R. Angeletti, 1994 .

Edman degradation sequence analysis of resin-bound peptides synthesized by 9-fluorenylmethoxycarbonyl chemistry.

G. Fields, C. Fields, V. L. Vandrisse, 1993, Peptide research.

Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases.

G. Fields, H. Nagase, J. Lauer-Fields, 2000, Journal of chromatography. A.

Collagenolytic Matrix Metalloproteinase Structure-Function Relationships: Insights From Molecular Dynamics Studies.

G. Fields, Tatyana G. Karabencheva-Christova, C. Christov, 2017, Advances in protein chemistry and structural biology.

Comparative proteomic analysis of matched primary and metastatic melanoma cell lines.

T. Brück, G. Fields, R. Kerr, 2008, Journal of proteome research.

Development of a convenient peptide‐based assay for lysyl hydroxylase

K. Brew, G. Fields, M. Cudic, 2008, Biopolymers.

Selective hydrolysis of triple-helical peptides by matrix metalloproteinases

G. Fields, H. Nagase, Janelle L. Lauer-Fields, 2002 .

Melanoma cell adhesion and spreading activities of a synthetic 124-residue triple-helical "mini-collagen".

G. Fields, C. Fields, S. Drake, 1993, The Journal of biological chemistry.

Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences.

K. Brew, C. Overall, G. Fields, 2007, Biochemistry.

The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity*

K. Brew, C. Overall, G. Fields, 2006, Journal of Biological Chemistry.

Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids.

R. Leblanc, G. Sui, G. Fields, 2003, Analytical biochemistry.

Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities.

M. Schwartz, G. Fields, D. Hurst, 2004, The Biochemical journal.

Development of HTS Assays and Pilot Screen for Inhibitors of Metalloproteases Meprin α and β

T. Spicer, G. Fields, P. Hodder, 2015 .

Skeletal muscle proteome expression differentiates severity of cancer cachexia in mice and identifies loss of fragile X mental retardation syndrome‐related protein 1

G. Fields, R. Feresin, A. V. Khamoui, 2022, Proteomics.

Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage

C. Ge, R. Holmdahl, G. Fields, 2022, Arthritis Research & Therapy.

Development of a putative Zn2+-chelating but highly selective MMP-13 inhibitor.

Mark S. Sundrud, G. Fields, M. Cameron, 2022, Bioorganic & medicinal chemistry letters.

Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.

P. Hart, Alexander B. Taylor, G. Fields, 2017, Journal of medicinal chemistry.

Enzymatic turnover of macromolecules generates long-lasting protein–water-coupled motions beyond reaction steady state

G. Fields, M. Havenith, Moran Grossman, 2014, Proceedings of the National Academy of Sciences.

Target-Based Proteolytic Profiling for Characterizing Cancer Progression

Scott A. Busby, M. J. Chalmers, P. Griffin, 2006 .

Inhibition of melanoma cell binding to type IV collagen by analogs of cell adhesion regulator.

G. Fields, J. Lauer, L. Furcht, 1997, Journal of medicinal chemistry.

The collagen triple-helix: correlation of conformation with biological activities.

G. Fields, 1995, Connective tissue research.

Promotion of human platelet adhesion and aggregation by a synthetic, triple-helical "mini-collagen".

J. White, G. Fields, C. Fields, 1994, The Journal of biological chemistry.

Mass-spectrometric approaches for DNA-based genetic screening.

G. Fields, 1997, Clinical chemistry.

Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates.

G. Fields, H. Nagase, T. Broder, 2001, Biochemistry.

The Role of Collagen Charge Clusters in the Modulation of Matrix Metalloproteinase Activity*

G. Fields, S. V. Van Doren, J. Lauer, 2013, The Journal of Biological Chemistry.

Local Conformation and Dynamics of Isoleucine in the Collagenase Cleavage Site Provide a Recognition Signal for Matrix Metalloproteinases*

J. Baum, G. Fields, Jianxi Xiao, 2010, The Journal of Biological Chemistry.

Collagenolytic Matrix Metalloproteinase Activities toward Peptomeric Triple-Helical Substrates.

G. Fields, M. Stawikowski, Roma Stawikowska, 2015, Biochemistry.

Synthesis and biological applications of collagen-model triple-helical peptides.

G. Fields, 2010, Organic & biomolecular chemistry.

Defining the Roles of Collagen and Collagen‐Like Proteins Within the Proteome

Gregg B. Fields, G. Fields, D. Baronas-Lowell, 2003 .

Matrix metalloproteinases and collagen catabolism.

G. Fields, Janelle L. Lauer-Fields, D. Juska, 2002, Biopolymers.

Collagenase unwinds triple‐helical collagen prior to peptide bond hydrolysis

D. Dinakarpandian, G. Fields, R. Visse, 2004, The EMBO journal.

Synthetic lipidation of peptides and amino acids: monolayer structure and properties.

Matthew Tirrell, Gregg B. Fields, M. Tirrell, 1995 .

Sequence dependence of aspartimide formation during 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis

G. Fields, C. Fields, J. Lauer, 1995, Letters in Peptide Science.

Difficulties encountered during glycopeptide syntheses.

G. Fields, J. Borgia, H. Abbasi, 2001, Journal of biomolecular techniques : JBT.

Minimization of tryptophan alkylation following 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis

G. Fields, C. Fields, 1993 .

Methods for the Construction of Collagen-Based Triple-Helical Peptides Designed as Matrix Metalloproteinase Inhibitors.

G. Fields, 2019, Methods in molecular biology.

Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases

G. Fields, 2019, Front. Immunol..

Design and Use of Synthetic Peptides as Biological Models

G. Fields, J. Lauer, 1998 .

MMP-12 Catalytic Domain Recognizes Triple Helical Peptide Models of Collagen V with Exosites and High Activity*

G. Fields, S. V. Van Doren, Mark O. Palmier, 2008, Journal of Biological Chemistry.

Effects of Drug Hydrophobicity on Liposomal Stability

G. Fields, E. M. Rezler, David R. Khan, 2007, Chemical biology & drug design.

Introduction to Peptide Synthesis

G. Fields, M. Stawikowski, 2012, Current protocols in protein science.

Introduction to Peptide Synthesis

G. Fields, 2002, Current protocols in molecular biology.

Introduction to Peptide Synthesis

G. Fields, 2002, Current protocols in immunology.

Introduction to Peptide Synthesis

G. Fields, 2001, Current protocols in protein science.

Thermodynamic considerations of solid-phase peptide synthesis

G. Fields, C. Fields, 1991 .

Peptide‐Based Inhibitors of Enzymes

G. Fields, A. Knapinska, S. Amar, 2015 .

Tricine as a convenient scaffold for the synthesis of C-terminally branched collagen-model peptides.

G. Fields, M. Stawikowski, 2018, Tetrahedron letters.

Glycosylation Modulates Melanoma Cell α2β1 and α3β1 Integrin Interactions with Type IV Collagen*

G. Fields, M. Cudic, M. Stawikowski, 2014, The Journal of Biological Chemistry.

Improved synthesis of 5-hydroxylysine (Hyl) derivatives.

G. Fields, M. Cudic, J. Lauer-Fields, 2008, The journal of peptide research : official journal of the American Peptide Society.

Solvents for solid-phase peptide synthesis.

G. Fields, C. Fields, 1994, Methods in molecular biology.

Theory for the aggregation of proteins and copolymers

Ken A. Dill, Gregg B. Fields, K. Dill, 1992 .

Screening MT1-MMP Activity and Inhibition in Three-Dimensional Tumor Spheroids

G. Fields, A. Knapinska, B. Larson, 2023, Biomedicines.

Integrative genomic and epigenomic analyses identified IRAK1 as a novel target for chronic inflammation-driven prostate tumorigenesis

G. Fields, W. Asghar, M. Pavlovic, 2021, bioRxiv.

Characterization and regulation of MT1‐MMP cell surface‐associated activity

A. Strongin, S. Weiss, R. Fridman, 2019, Chemical biology & drug design.

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

G. Fields, S. Pahwa, M. Stawikowski, 2014, Cancers.

Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability.

G. Fields, H. Nagase, Janelle L. Lauer-Fields, 2004, Biochemistry.

A PCNA-Derived Cell Permeable Peptide Selectively Inhibits Neuroblastoma Cell Growth

Jeremy M. Stark, Caroline M. Li, J. Stark, 2014, PloS one.

Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases*

M. Bernardo, R. Fridman, Malika Kumarasiri, 2013, The Journal of Biological Chemistry.

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

Mitchell D. Miller, G. Phillips, J. Tainer, 2021, Communications Biology.

The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells

Yate-Ching Yuan, P. Chu, J. Sandoval, 2015, EBioMedicine.

Regulation of Collagenase Activities of Human Cathepsins by Glycosaminoglycans*

M. Bogyo, G. Fields, R. Gordon, 2004, Journal of Biological Chemistry.

Self-assembling amphiphiles for construction of protein molecular architecture

Matthew Tirrell, Gregg B. Fields, M. Tirrell, 1996 .

The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

G. Fields, 2019, Cells.

A Peptide Mimicking a Region in Proliferating Cell Nuclear Antigen Specific to Key Protein Interactions Is Cytotoxic to Breast Cancer

Yun-Ru Chen, D. Ann, R. Hickey, 2015, Molecular Pharmacology.

The history of matrix metalloproteinases: milestones, myths, and misperceptions.

M. Lindsey, G. Fields, R. Iyer, 2012, American journal of physiology. Heart and circulatory physiology.

Selective Modulation of Matrix Metalloproteinase 9 (MMP-9) Functions via Exosite Inhibition*

Robert P. Hammer, Keith Brew, Gregg B. Fields, 2008, Journal of Biological Chemistry.

Chemical Biology for Understanding Matrix Metalloproteinase Function

G. Fields, A. Knapinska, 2012, Chembiochem : a European journal of chemical biology.

Solid-phase synthesis of triple-helical collagen-model peptides

G. Fields, C. Fields, J. Lauer, 1996, Letters in Peptide Science.

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13

G. Fields, Frank T. Coppo, P. Tummino, 2007, Protein science : a publication of the Protein Society.

Photoreactive analog of peptide FN-C/H-V from the carboxy-terminal heparin-binding domains of fibronectin supports endothelial cell adhesion and spreading on biomaterial surfaces.

G. Fields, D. Mooradian, J. B. Huebsch, 1996, Journal of biomedical materials research.

Application of a triple‐helical peptide inhibitor of MMP‐2/MMP‐9 to examine T‐cell activation in experimental autoimmune encephalomyelitis

G. Fields, Lillian C. Onwuha-Ekpete, 2022, Peptide Science.

Interstitial Collagen Catabolism*

G. Fields, 2013, The Journal of Biological Chemistry.

Cellular recognition of synthetic peptide amphiphiles in self-assembled monolayer films.

M. Tirrell, G. Fields, M. Tirrell, 1999, Biomaterials.

A synergy between the catalytic and structural Zn(II) ions and the enzyme and substrate dynamics underlies the structure–function relationships of matrix metalloproteinase collagenolysis

G. Fields, Shobhit S. Chaturvedi, A. Varghese, 2021, JBIC Journal of Biological Inorganic Chemistry.

Dissecting MMP P10′ and P11′ subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library

G. Fields, Michal Tokmina-Roszyk, 2018, The Journal of Biological Chemistry.

Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study.

G. Fields, M. Cameron, W. Roush, 2018, Bioorganic & medicinal chemistry.

Matrix metalloproteinase collagenolysis in health and disease.

G. Fields, Lyndsay Smith, S. Amar, 2017, Biochimica et biophysica acta. Molecular cell research.

Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.

H. Wong, G. Fields, W. Roush, 2017, Journal of medicinal chemistry.

Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity

C. Luchinat, L. Cerofolini, M. Fragai, 2016, Scientific Reports.

Importance of the Linker Region in Matrix Metalloproteinase-1 Domain Interactions.

G. Fields, Warispreet Singh, C. Christov, 2016, RSC advances.

Path to Collagenolysis

G. Fields, S. V. Van Doren, S. Prior, 2016, The Journal of Biological Chemistry.

Matrix Metalloproteinase Inhibition by Heterotrimeric Triple‐Helical Peptide Transition State Analogues

G. Fields, Manishabrata Bhowmick, Roma Stawikowska, 2015, Chembiochem : a European journal of chemical biology.

Biophysical studies of matrix metalloproteinase/triple-helix complexes.

G. Fields, 2014, Advances in protein chemistry and structural biology.

Examination of Matrix Metalloproteinase-1 in Solution

D. Svergun, C. Luchinat, L. Cerofolini, 2013, The Journal of Biological Chemistry.

Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis.

I. Bertini, C. Luchinat, M. Fragai, 2012, Journal of the American Chemical Society.

The Interface between Catalytic and Hemopexin Domains in Matrix Metalloproteinase-1 Conceals a Collagen Binding Exosite*

G. Fields, S. Prior, C. Read, 2011, The Journal of Biological Chemistry.

Identification of Specific Hemopexin-like Domain Residues That Facilitate Matrix Metalloproteinase Collagenolytic Activity*

Scott A. Busby, M. J. Chalmers, P. Griffin, 2009, The Journal of Biological Chemistry.

A model for interstitial collagen catabolism by mammalian collagenases.

G. Fields, G B Fields, Gregg B. Fields, 1991, Journal of theoretical biology.

Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).

G. Fields, C. Fields, G B Fields, 1994, The Journal of biological chemistry.

Matrix Metalloproteinases: From Structure to Function

G. Fields, M. Stawikowski, 2015 .

1 Matrix Metalloproteinases : From Structure to Function

G. Fields, M. Stawikowski, 2015 .

Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging

Samuel Achilefu, Philip P. Cheney, Gregg B. Fields, 2009, BiOS.

Proteolytic profiling of the extracellular matrix degradome.

G. Fields, D. Baronas-Lowell, Janelle L. Lauer-Fields, 2007, Methods in molecular biology.

Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space*

S. Hanash, M. Yamauchi, J. Kurie, 2016, The Journal of Biological Chemistry.

Induction of protein-like molecular architecture by monoalkyl hydrocarbon chains.

G. Fields, P. Forns, J. Lauer-Fields, 2000, Biopolymers.

Three-dimensional orthogonal solid-phase synthesis of cell-adhesive, triple-helical collagen-model peptides

G. Fields, C. Fields, 1993 .

The normalization of gene expression data in melanoma: investigating the use of glyceraldehyde 3-phosphate dehydrogenase and 18S ribosomal RNA as internal reference genes for quantitative real-time PCR.

G. Fields, Janelle L. Lauer-Fields, Orsolya Giricz, 2008, Analytical biochemistry.

Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2).

G. Fields, Xiaoping Xu, B. Steffensen, 2012, Matrix biology : journal of the International Society for Matrix Biology.

Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities

G. Fields, Manishabrata Bhowmick, Trista K. Robichaud, 2012, Molecules.

Synthesis and biological applications of collagen-model triple-helical peptides.

G. Fields, 2010, Organic & biomolecular chemistry.

Clinical Implications of Compounds Designed to Inhibit ECM‐Modifying Metalloproteinases

G. Fields, D. Minond, S. Amar, 2017, Proteomics.

Solvation effects in solid-phase peptide synthesis

G. Fields, C. Fields, 1991 .

A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis.

Michael E. Hall, M. Lindsey, F. Zouein, 2015, Journal of the American College of Cardiology.

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.

P. Nilsson, C. Ge, R. Holmdahl, 2017, JCI insight.

Angiogenesis in Collagen I Requires α2β1 Ligation of a GFP*GER Sequence and Possibly p38 MAPK Activation and Focal Adhesion Disassembly*

Shawn M. Sweeney, Gregg B. Fields, Renato V. Iozzo, 2003, Journal of Biological Chemistry.

Gregg B Fields, Martina Havenith, Matthias Heyden, 2011, Nature Structural &Molecular Biology.

Novel Pyrrolidine Diketopiperazines Selectively Inhibit Melanoma Cells via Induction of Late-Onset Apoptosis

M. Giulianotti, R. Houghten, G. Kaushik, 2014, Journal of medicinal chemistry.

Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors.

K. Brew, G. Fields, Janelle L. Lauer-Fields, 2007, Methods in molecular biology.

Melanoma Cell CD44 Interaction with the α1(IV)1263–1277 Region from Basement Membrane Collagen Is Modulated by Ligand Glycosylation*

K. Drauz, G. Fields, Janelle L. Lauer-Fields, 2003, The Journal of Biological Chemistry.

Promotion of fibroblast adhesion by triple-helical peptide models of type I collagen-derived sequences.

G. Fields, A. Miles, L. Furcht, 1996, The Journal of biological chemistry.

myths, and misperceptions The history of matrix metalloproteinases: milestones,

M. Lindsey, G. Fields, R. Iyer, 2012 .

Milestones, Myths, and (Mis)Perceptions

G. Fields, L. Merry, R. Iyer, 2012 .

The History of Matrix Metalloproteinases ( MMPs ) : 1 Milestones , Myths , and ( Mis ) Perceptions

G. Fields, L. Merry, R. Iyer, 2012 .

Triple-Helical Peptide Analysis of Collagenolytic Protease Activity

G. Fields, J. Lauer-Fields, J. L. Lauer-Fields, 2002, Biological chemistry.

Chemical synthesis of proteins.

G. Fields, J. Borgia, 2000, Trends in biotechnology.

Induction of Endothelial Cell Activation by a Triple Helical α2β1 Integrin Ligand, Derived from Type I Collagen α1(I)496–507*

G. Fields, D. Baronas-Lowell, Janelle L. Lauer-Fields, 2004, Journal of Biological Chemistry.

Activity of ADAM17 (a Disintegrin and Metalloprotease 17) Is Regulated by Its Noncatalytic Domains and Secondary Structure of its Substrates*

M. Giulianotti, R. Houghten, G. Fields, 2013, The Journal of Biological Chemistry.

New strategies for targeting matrix metalloproteinases

G. Fields, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Correlation of cleavage techniques with side-reactions following solid-phase peptide synthesis

Lynda F. Bonewald, L. C. Williams, Gregg B. Fields, 1995 .

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

Radleigh G. Santos, T. Spicer, G. Fields, 2016, Scientific reports.

Structure and dynamics of peptide-amphiphiles incorporating triple-helical proteinlike molecular architecture.

M. Tirrell, G. Fields, K. Mayo, 1999, Biochemistry.

Proteinlike molecular architecture: Biomaterial applications for inducing cellular receptor binding and signal transduction

Matthew Tirrell, Gregg B. Fields, Yoav Dori, 1998 .

Construction of biologically active protein molecular architecture using self-assembling peptide-amphiphiles.

M. Tirrell, G. Fields, Y. Dori, 1997, Methods in enzymology.

CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase.

G. Fields, Y. Shimizu, A. Chan, 1997, Journal of immunology.

Matrix metalloproteinases as reagents for cell isolation.

G. Fields, S. Matosevic, C. Zylberberg, 2016, Enzyme and microbial technology.

Development of a Förster resonance energy transfer assay for monitoring bacterial collagenase triple-helical peptidase activity.

G. Fields, Manishabrata Bhowmick, Michal Tokmina-Roszyk, 2014, Analytical biochemistry.

Ligand accessibility as means to control cell response to bioactive bilayer membranes.

S. Satija, H. Bianco-Peled, M. Tirrell, 2000, Journal of biomedical materials research.

Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides.

G. Fields, G B Fields, H. Nagase, 1996, Biopolymers.

Evaluation of a Triple-Helical Peptide with Quenched Fluorophores for Optical Imaging of MMP-2 and MMP-9 Proteolytic Activity

G. Fields, Jamee Bresee, M. Cudic, 2014, Molecules.

Selective Hydrolysis of Triple-helical Substrates by Matrix Metalloproteinase-2 and -9*

M. Stack, G. Fields, H. Nagase, 2003, The Journal of Biological Chemistry.

δ/ω-Plectoxin-Pt1a: An Excitatory Spider Toxin with Actions on both Ca2+ and Na+ Channels

G. Fields, Chun-Fang Wu, W. Branton, 2013, PloS one.

Hydrolysis of Triple-helical Collagen Peptide Models by Matrix Metalloproteinases*

G. Fields, K. Shimokawa, H. Nagase, 2000, The Journal of Biological Chemistry.

Using fluorogenic peptide substrates to assay matrix metalloproteinases.

G. Fields, 2010, Methods in molecular biology.

Synthesis of N α -(Fluoren-9-ylmethoxycarbonyl)- N ε -[(7- methoxycoumarin-4-yl)-acetyl]-L-lysine for Use in Solid-Phase Synthesis of Fluorogenic Substrates

G. Fields, N. B. Malkar, 2001 .

Synthesis and solid-phase application of suitably protected γ-hydroxyvaline building blocks

G. Fields, M. Cudic, F. Marí, 2007 .

Convenient synthesis of glycosylated hydroxylysine derivatives for use in solid-phase peptide synthesis

G. Fields, Janelle L. Lauer-Fields, N. B. Malkar, 2000 .

Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates.

M. Distefano, G. Fields, G B Fields, 1997, Chemistry & biology.

Analysis of Flavonoid‐Based Pharmacophores that Inhibit Aggrecanases (ADAMTS‐4 and ADAMTS‐5) and Matrix Metalloproteinases Through the Use of Topologically Constrained Peptide Substrates

G. Fields, M. Cudic, Janelle L. Lauer-Fields, 2009, Chemical biology & drug design.

MINIMAL LIPIDATION STABILIZES PROTEIN-LIKE MOLECULAR ARCHITECTURE

Gregg B. Fields, A. Tirrell, G. Fields, 1998 .

Perspectives on the synthesis and application of triple-helical, collagen-model peptides.

D. Prockop, G. Fields, Gregg B. Fields, 1996, Biopolymers.

Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors*

K. Brew, G. Fields, M. Cudic, 2007, Journal of Biological Chemistry.

Adhesion of alpha5beta1 receptors to biomimetic substrates constructed from peptide amphiphiles.

M. Tirrell, G. Fields, J. McCarthy, 2001, Biomaterials.

Application of Collagen-Model Triple-Helical Peptide-Amphiphiles for CD44-Targeted Drug Delivery Systems

G. Fields, C. Anderson, A. Zheleznyak, 2012, Journal of drug delivery.

The Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer

G. Fields, W. Asghar, N. Esiobu, 2023, Cancers.

MT1-MMP Binds Membranes by Opposite Tips of Its β Propeller to Position It for Pericellular Proteolysis.

B. An, T. Marcink, G. Fields, 2019, Structure.

Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors.

K. Brew, G. Fields, Shunzi Li, 2007, Journal of the American Chemical Society.

Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro

T. Spicer, P. Hart, Alexander B. Taylor, 2014, Journal of medicinal chemistry.

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

G. Fields, P. Hodder, W. Roush, 2011, Bioorganic & medicinal chemistry letters.

Analysis of racemization during "Standard" solid phase peptide synthesis: a multicenter study

W. T. Moore, R. Angeletti, J. McMurray, 1997 .

An all-D amino acid peptide model of alpha1(IV)531-543 from type IV collagen binds the alpha3beta1 integrin and mediates tumor cell adhesion, spreading, and motility.

G. Fields, J. McCarthy, L. Furcht, 1997, Biochemistry.

Protease-Activated Delivery and Imaging Systems

G. Fields, 2008 .

Transient collagen triple helix binding to a key metalloproteinase in invasion and development.

Raghavendar Reddy Sanganna Gari, G. Fields, S. V. Van Doren, 2015, Structure.

Interactions of Type IV Collagen and Its Domains with Human Mesangial Cells*

D. Clegg, E. Wayner, E. Tsilibary, 1998, The Journal of Biological Chemistry.

Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst

Kutty Selva Nandakumar, R. Holmdahl, G. Fields, 2022, Molecular Biomedicine.

Model peptides of interstitial collagens: hydrolysis by matrix metalloproteinases

G. Fields, K. Shimokawa, H. Nagase, 2002 .

Comparison of metalloproteinase protein and activity profiling.

G. Fields, J. Lauer, Orsi Giricz, 2011, Analytical biochemistry.

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.

G. Fields, P. Hodder, S. Saldanha, 2009, Bioorganic & medicinal chemistry.

Imaging Matrix Metalloproteinase Activity Implicated in Breast Cancer Progression.

G. Fields, M. Stawikowski, 2016, Methods in molecular biology.

Solid-phase peptide synthesis and solid-state NMR spectroscopy of [Ala3-15N][Val1]gramicidin A.

H. V. Van Wart, G. Fields, T. Cross, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Lips symposia in print and other issues

B. Dunn, F. Albericio, G. Fields, 1996, Letters in peptide science.

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

T. Spicer, G. Fields, L. Scampavia, 2020, Pharmaceuticals.

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

T. Spicer, G. Fields, Hajeung Park, 2020, Pharmaceuticals.

Brief report Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the (cid:1) 2 (cid:2) 1-integrin receptor

R. Iozzo, G. Fields, A. McQuillan, 2007 .

Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.

T. Spicer, G. Fields, P. Hodder, 2008, Analytical biochemistry.

Solid‐Phase synthesis and stability of triple‐helical peptides incorporating native collagen sequences

G. Fields, C. Fields, A. Miles, 1993, Biopolymers.

Matrix Metalloproteinase Triple-Helical Peptide Inhibitors: Potential Cross-Reactivity with Caspase-11

G. Fields, A. Knapinska, M. Hart, 2019, Molecules.

Synthesis of Fmoc-Gly-Ile Phosphinic Pseudodipeptide: Residue Specific Conditions for Construction of Matrix Metalloproteinase Inhibitor Building Blocks

G. Fields, Manishabrata Bhowmick, 2012, International Journal of Peptide Research and Therapeutics.

Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies

Gregg B Fields, G. Fields, Sabrina Amar, 2015, Expert review of proteomics.

Correction to Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis.

C. Ge, Jie Yang, R. Holmdahl, 2020, ACS Chemical Biology.

Effect of ligand conformation on melanoma cell alpha3beta1 integrin-mediated signal transduction events: implications for a collagen structural modulation mechanism of tumor cell invasion.

G. Fields, J. Lauer, C. Gendron, 1998, Biochemistry.

Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability

G. Fields, A. Knapinska, Anu Herd, 2020, ChemMedChem.

Conopeptides: Unique pharmacological agents that challenge current peptide methodologies

G. Fields, F. Mars, 2003 .

A Novel Laminin Domain Involved in Adhesion of Endothelial Cells

G. Fields, A. Charonis, G. Koliakos, 1994 .

Glycosylation of A Disintegrin And Metalloprotease 17 (ADAM17) Affects its Activity and Inhibition

M. Giulianotti, R. Houghten, G. Fields, 2015 .

Characterization of peptide-amphiphiles possessing cellular activation sequences.

G. Fields, Janelle L. Lauer-Fields, N. B. Malkar, 2003, Biomacromolecules.

Activity of ADAM17 (a Disintegrin and Metalloprotease 17) Is Regulated by Its Noncatalytic Domains and Secondary Structure of its Substrates*

M. Giulianotti, R. Houghten, G. Fields, 2013, Journal of Biological Chemistry.

Transient collagen triple helix binding to a key metalloproteinase in invasion and development.

G. Fields, S. V. Van Doren, G. King, 2015, Structure.

A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis.

Michael E. Hall, M. Lindsey, R. Lange, 2015, Journal of the American College of Cardiology.

The history of matrix metalloproteinases: milestones, myths, and misperceptions.

M. Lindsey, G. Fields, R. Iyer, 2012, American journal of physiology. Heart and circulatory physiology.

Solid-phase synthesis of O-palmitoylated peptides

G. Fields, C. Fields, W. Branton, 1993 .

Type I collagen-heparin interactions in angiogenesis

Shawn M. Sweeney, G. Fields, C. Fields, 1997 .

Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2).

G. Fields, Xiaoping Xu, B. Steffensen, 2012, Matrix biology : journal of the International Society for Matrix Biology.

Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies

G. Fields, S. Amar, 2015, Expert review of proteomics.

Northumbria Research Link

G. Fields, Warispreet Singh, C. Christov, 2021 .

Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1.

G. Fields, Sodiq O. Waheed, A. Varghese, 2022, Chemphyschem : a European journal of chemical physics and physical chemistry.

Effects of the Nature of the Metal Ion, Protein and Substrate on the Catalytic Center in Matrix Metalloproteinase-1: Insights from Multilevel MD, QM/MM and QM Studies.

G. Fields, Shobhit S. Chaturvedi, A. Varghese, 2021, Chemphyschem : a European journal of chemical physics and physical chemistry.

Conformational Dynamics of Matrix Metalloproteinase-1·Triple-Helical Peptide Complexes.

G. Fields, C. Christov, Tatyana G. Karabencheva‐Christova, 2017, The journal of physical chemistry. B.

The synthesis and application of Fmoc-Lys(5-Fam) building blocks.

G. Fields, Michal Tokmina-Roszyk, Dorota Tokmina‐Roszyk, 2013, Biopolymers.

Perspectives on the Synthesis and Application of Triple‐Helical, Collagen‐Model Peptides

D. Prockop, G. Fields, 2010 .

Modulation of triple-helical stability and subsequent melanoma cellular responses by single-site substitution of fluoroproline derivatives.

G. Fields, J. Borgia, Janelle L. Lauer-Fields, 2002, Biochemistry.

Protein-like molecular architecture: biomaterial applications for inducing cellular receptor binding and signal transduction.

M. Tirrell, G. Fields, Y. Dori, 1998, Biopolymers.

Formation of a Disulfide Bond in an Octreotide-Like Peptide: A Multicenter Study

W. T. Moore, R. Angeletti, J. McMurray, 1996 .

Chemical Biology for Understanding Matrix Metalloproteinase Function

G. Fields, A. Knapinska, 2012, Chembiochem : a European journal of chemical biology.

Determination of penetratin secondary structure in live cells with Raman microscopy.

Andrew C. Terentis, G. Fields, M. Cudic, 2010, Journal of the American Chemical Society.

Allyl-based orthogonal solid phase peptide synthesis

M. Lyttle, D. Hudson, F. Albericio, 1993 .